instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Disruption of NAS1 resulted in several phenotypes, including lethality and temperature-sensitive growth, depending on the genetic background of the cells used.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one ... | <Mentions>: [nas1]
<Options>: A: nas1 (xenopus tropicalis) (aka solute carrier family 13 member 1)
B: nas1 (arabidopsis thaliana) (aka nicotianamine synthase 1)
C: nas1 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle base subunit rpn1)
D: anorexia nervosa, susceptibility to, 1 (homo sapiens) (aka a... | [C] |
<Instruct>: Given the context 'The human p97 cDNA suppressed the growth defect of nas1 disruptant cells, when expressed from single-copy or multi-copy vectors, indicating that p97 is functionally equivalent to yeast Nas1p.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [p97; nas1p]
<Options>: A: nas1 (xenopus laevis) (solute carrier family 13 member 1 s homeolog (xenopus laevis)) (aka solute carrier family 13 member 1 s homeolog)
B: nas7 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle lid subunit rpn9)
C: ec97 (homo sapiens) (aka vps35 endosomal prote... | [H; E] |
<Instruct>: Given the context 'The human p97 cDNA suppressed the growth defect of nas1 disruptant cells, when expressed from single-copy or multi-copy vectors, indicating that p97 is functionally equivalent to yeast Nas1p.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [p97; nas1p]
<Options>: A: nas1 (arabidopsis thaliana) (aka nicotianamine synthase 1)
B: nas1 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle base subunit rpn1)
C: nas6p (saccharomyces cerevisiae s288c) (aka nas6p)
D: hspc197 (homo sapiens) (aka bet1 golgi vesicular membrane trafficking... | [E; B] |
<Instruct>: Given the context 'Culturing of the temperature-sensitive nas1 cells at the restrictive temperature promoted the accumulation polyubiquitinated cellular proteins, implying that the 26S proteasome requires a functional Nas1p subunit for ubiquitin-dependent proteolysis.', select the correct biomedical concept... | <Mentions>: [nas1p]
<Options>: A: nas1 (xenopus tropicalis) (aka solute carrier family 13 member 1)
B: nas1 (xenopus laevis) (solute carrier family 13 member 1 s homeolog (xenopus laevis)) (aka solute carrier family 13 member 1 s homeolog)
C: nas6p (saccharomyces cerevisiae s288c) (aka nas6p)
D: nas7 (saccharomyces cer... | [E] |
<Instruct>: Given the context 'These results indicate that p97/Nas1p plays an important regulatory role in the function of the 26S proteasome.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p97; nas1p]
<Options>: A: nas1 (xenopus tropicalis) (aka solute carrier family 13 member 1)
B: nas1 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle base subunit rpn1)
C: ec97 (homo sapiens) (aka vps35 endosomal protein sorting factor like)
D: p97 (homo sapiens) (proteasome 26s subunit ... | [D; B] |
<Instruct>: Given the context 'These results indicate that p97/Nas1p plays an important regulatory role in the function of the 26S proteasome.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p97; nas1p]
<Options>: A: nas1 (xenopus tropicalis) (aka solute carrier family 13 member 1)
B: p97 (drosophila melanogaster) (regulatory particle non-atpase 1 (drosophila melanogaster)) (aka regulatory particle non-atpase 1)
C: nas4 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle lid s... | [I; J] |
<Instruct>: Given the context 'These results indicate that p97/Nas1p plays an important regulatory role in the function of the 26S proteasome.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p97; nas1p]
<Options>: A: nas4 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle lid subunit rpn6)
B: nas1 (xenopus tropicalis) (aka solute carrier family 13 member 1)
C: p97 (drosophila melanogaster) (regulatory particle non-atpase 1 (drosophila melanogaster)) (aka regulatory particle n... | [E; J] |
<Instruct>: Given the context 'Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.
Transforming growth factor-beta TGF-beta is the prototype for a family of extracellular proteins that affect cell proliferation and tissue differentiation.', select the correct biomedical concept for each ... | <Mentions>: [tgf-beta; transforming growth factor-beta]
<Options>: A: transforming growth factor beta receptor 3 (homo sapiens) (aka transforming growth factor beta receptor 3)
B: transforming growth factor beta 3 (homo sapiens) (aka transforming growth factor beta 3)
C: transforming growth factor beta 1 (xenopus tropi... | [E; E] |
<Instruct>: Given the context 'Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.
Transforming growth factor-beta TGF-beta is the prototype for a family of extracellular proteins that affect cell proliferation and tissue differentiation.', select the correct biomedical concept for each ... | <Mentions>: [tgf-beta; transforming growth factor-beta]
<Options>: A: tgf-beta2 (homo sapiens) (aka transforming growth factor beta 2)
B: transforming growth factor beta 1 (xenopus tropicalis) (aka transforming growth factor beta 1)
C: transforming growth factor beta receptor 3 (homo sapiens) (aka transforming growth f... | [G; G] |
<Instruct>: Given the context 'TGF-beta-related factors, including BMP-2/4, Dpp and activin, act through two types of serine/threonine kinase receptors which can form a heteromeric complex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [dpp]
<Options>: A: dpp (drosophila melanogaster) (dipeptidyl aminopeptidase iii (drosophila melanogaster)) (aka dipeptidyl aminopeptidase iii)
B: dppi (homo sapiens) (aka cathepsin c)
C: dpp7 (homo sapiens) (aka dipeptidyl peptidase 7)
D: dpp3 (homo sapiens) (aka dipeptidyl peptidase 3)
E: None of the abov... | [E] |
<Instruct>: Given the context 'In Drosophila, Mad is required for signalling by Dpp.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dpp]
<Options>: A: dpp (drosophila melanogaster) (dipeptidyl aminopeptidase iii (drosophila melanogaster)) (aka dipeptidyl aminopeptidase iii)
B: dpp3 (homo sapiens) (aka dipeptidyl peptidase 3)
C: dpp (homo sapiens) (dipeptidyl peptidase 7 (homo sapiens)) (aka dipeptidyl peptidase 7)
D: dppi (homo sapiens... | [E] |
<Instruct>: Given the context 'We have isolated complementary DNAs for four human Mad homologues, one of which, hMAD-4, is identical to DPC-4, a candidate tumour suppressor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [hmad-4; dpc-4]
<Options>: A: ahd-4 (mus musculus) (aka aldehyde dehydrogenase family 3, subfamily a1)
B: dpc4 (xenopus laevis) (smad family member 4 s homeolog (xenopus laevis)) (aka smad family member 4 s homeolog)
C: smad family member 4 (homo sapiens) (aka smad family member 4)
D: cadm4 (homo sapiens) (... | [C; C] |
<Instruct>: Given the context 'We have isolated complementary DNAs for four human Mad homologues, one of which, hMAD-4, is identical to DPC-4, a candidate tumour suppressor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [hmad-4; dpc-4]
<Options>: A: cell death protein 4 (caenorhabditis elegans) (aka cell death protein 4)
B: odad4 (homo sapiens) (aka outer dynein arm docking complex subunit 4)
C: dsc-4 (caenorhabditis elegans) (aka microsomal triglyceride transfer protein homolog)
D: amd4 (homo sapiens) (aka protein kinase ... | [G; G] |
<Instruct>: Given the context 'We have isolated complementary DNAs for four human Mad homologues, one of which, hMAD-4, is identical to DPC-4, a candidate tumour suppressor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [hmad-4; dpc-4]
<Options>: A: dpc4 (xenopus laevis) (smad family member 4 s homeolog (xenopus laevis)) (aka smad family member 4 s homeolog)
B: cadm4 (homo sapiens) (aka cell adhesion molecule 4)
C: hda-4 (caenorhabditis elegans) (aka histone deacetylase 4)
D: dsc-4 (caenorhabditis elegans) (aka microsomal ... | [I; I] |
<Instruct>: Given the context 'hMAD-3 and -4 synergized to induce strong ligand-independent TGF-beta-like responses.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tgf-beta]
<Options>: A: ifn-beta (homo sapiens) (aka interferon beta 1)
B: tgf-beta3 (homo sapiens) (aka transforming growth factor beta 3)
C: transforming growth factor beta 2 (homo sapiens) (aka transforming growth factor beta 2)
D: tgfb (homo sapiens) (aka transforming growth factor beta 1)
E: None of t... | [D] |
<Instruct>: Given the context 'When truncated at their carboxy termini, hMAD-3 and -4 act as dominant-negative inhibitors of the normal TGF-beta response.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [tgf-beta]
<Options>: A: tgf-beta3 (homo sapiens) (aka transforming growth factor beta 3)
B: transforming growth factor beta 2 (homo sapiens) (aka transforming growth factor beta 2)
C: tgfb1 (homo sapiens) (aka transforming growth factor beta 1)
D: ifn-beta (homo sapiens) (aka interferon beta 1)
E: None of ... | [C] |
<Instruct>: Given the context 'The activity of hMAD-3 and -4 was regulated by the TGF-beta receptors, and hMAD-3 but not hMAD-4 was phosphorylated and associated with the ligand-bound receptor complex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [tgf-beta; hmad-3; hmad-4]
<Options>: A: hsmad3 (homo sapiens) (aka smad family member 3)
B: hmad-2 (homo sapiens) (aka smad family member 2)
C: amd4 (homo sapiens) (aka protein kinase cgmp-dependent 2)
D: transforming growth factor beta 3 (homo sapiens) (aka transforming growth factor beta 3)
E: tgf-beta2 ... | [K; A; M] |
<Instruct>: Given the context 'The activity of hMAD-3 and -4 was regulated by the TGF-beta receptors, and hMAD-3 but not hMAD-4 was phosphorylated and associated with the ligand-bound receptor complex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [tgf-beta; hmad-3; hmad-4]
<Options>: A: transforming growth factor beta 2 (homo sapiens) (aka transforming growth factor beta 2)
B: mad4 (homo sapiens) (aka max dimerization protein 4)
C: amd3 (homo sapiens) (aka bone morphogenetic protein receptor type 1b)
D: mam3 (homo sapiens) (aka mastermind like trans... | [E; J; K] |
<Instruct>: Given the context 'The activity of hMAD-3 and -4 was regulated by the TGF-beta receptors, and hMAD-3 but not hMAD-4 was phosphorylated and associated with the ligand-bound receptor complex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [tgf-beta; hmad-3; hmad-4]
<Options>: A: mam3 (homo sapiens) (aka mastermind like transcriptional coactivator 2)
B: tgfb1 (homo sapiens) (aka transforming growth factor beta 1)
C: transforming growth factor beta 2 (homo sapiens) (aka transforming growth factor beta 2)
D: ifn-beta (homo sapiens) (aka interfe... | [B; M; F] |
<Instruct>: Given the context 'These results define hMAD-3 and -4 as effectors of the TGF-beta response and demonstrate a function for DPCA-4/hMAD-4 as a tumour suppressor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [tgf-beta; dpca-4; hmad-4]
<Options>: A: major affective disorder 4 (homo sapiens) (aka major affective disorder 4)
B: dpc4 (homo sapiens) (aka smad family member 4)
C: d-sas-4 (drosophila melanogaster) (aka spindle assembly abnormal 4)
D: mad4 (homo sapiens) (aka max dimerization protein 4)
E: ifn-beta (ho... | [L; B; B] |
<Instruct>: Given the context 'These results define hMAD-3 and -4 as effectors of the TGF-beta response and demonstrate a function for DPCA-4/hMAD-4 as a tumour suppressor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [tgf-beta; dpca-4; hmad-4]
<Options>: A: transforming growth factor beta 2 (homo sapiens) (aka transforming growth factor beta 2)
B: cell division cycle associated 4 (xenopus tropicalis) (aka cell division cycle associated 4)
C: transforming growth factor beta 3 (homo sapiens) (aka transforming growth facto... | [J; L; L] |
<Instruct>: Given the context 'These results define hMAD-3 and -4 as effectors of the TGF-beta response and demonstrate a function for DPCA-4/hMAD-4 as a tumour suppressor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [tgf-beta; dpca-4; hmad-4]
<Options>: A: ciliary dyskinesia, primary, 4 (homo sapiens) (aka ciliary dyskinesia, primary, 4)
B: ifn-beta (homo sapiens) (aka interferon beta 1)
C: tgf-beta1 (homo sapiens) (aka transforming growth factor beta 1)
D: dpc4 (homo sapiens) (aka smad family member 4)
E: dsc-4 (caeno... | [C; D; D] |
<Instruct>: Given the context 'These results define hMAD-3 and -4 as effectors of the TGF-beta response and demonstrate a function for DPCA-4/hMAD-4 as a tumour suppressor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [tgf-beta; dpca-4; hmad-4]
<Options>: A: odad4 (homo sapiens) (aka outer dynein arm docking complex subunit 4)
B: dpc4 (xenopus tropicalis) (smad family member 4 (xenopus tropicalis)) (aka smad family member 4)
C: transforming growth factor beta 3 (homo sapiens) (aka transforming growth factor beta 3)
D: ah... | [F; M; M] |
<Instruct>: Given the context 'The C5a chemoattractant receptor mediates mucosal defence to infection.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c5a chemoattractant receptor]
<Options>: A: c5ar1 (sus scrofa) (aka complement c5a receptor 1)
B: c5ar1 (homo sapiens) (aka complement c5a receptor 1)
C: c5ar (mus musculus) (aka complement component 5a receptor 1)
D: c5ar2 (homo sapiens) (aka complement c5a receptor 2)
E: c5ar1 (bos taurus) (aka complemen... | [B] |
<Instruct>: Given the context 'A family of G-protein-coupled chemoattractant receptors is known to mediate the transport and activation of neutrophils and macrophages This family includes receptors for chemokines, such as interleukin-8, bacterial formylated peptides, platelet-activating factor, leukotriene B4, and the ... | <Mentions>: [interleukin-8]
<Options>: A: ccl8 (homo sapiens) (aka c-c motif chemokine ligand 8)
B: fgf-8 (homo sapiens) (aka fibroblast growth factor 8)
C: c-x-c motif chemokine ligand 8 (homo sapiens) (aka c-x-c motif chemokine ligand 8)
D: il18 (homo sapiens) (aka interleukin 18)
E: il1f8 (homo sapiens) (aka interle... | [C] |
<Instruct>: Given the context 'Here we show that mice deficient in the chemoattractant C5a receptor, in comparison to their wild-type littermates, were unable to clear intrapulmonary-instilled Pseudomonas aeruginosa, despite a marked increase in neutrophil influx, and succumbed to pneumonia.', select the correct biomed... | <Mentions>: [c5a receptor]
<Options>: A: c5ar1 (sus scrofa) (aka complement c5a receptor 1)
B: c5ar (mus musculus) (aka complement component 5a receptor 1)
C: complement c5a receptor 2 (homo sapiens) (aka complement c5a receptor 2)
D: complement c5a receptor 1 (homo sapiens) (aka complement c5a receptor 1)
E: complemen... | [D] |
<Instruct>: Given the context 'These C5a-receptor-deficient mice challenged with sublethal inocula of Pseudomonas become superinfected with secondary bacterial strains.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sepa... | <Mentions>: [c5a-receptor]
<Options>: A: c5ar1 (homo sapiens) (aka complement c5a receptor 1)
B: complement c5a receptor 1 (bos taurus) (aka complement c5a receptor 1)
C: c5ar1 (sus scrofa) (aka complement c5a receptor 1)
D: complement c5a receptor 2 (homo sapiens) (aka complement c5a receptor 2)
E: c5ar (mus musculus)... | [A] |
<Instruct>: Given the context 'We conclude that the C5a receptor has a non-redundant function, and is required for mucosal host defence in the lung.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c5a receptor]
<Options>: A: complement c5a receptor 2 (homo sapiens) (aka complement c5a receptor 2)
B: c5ar1 (bos taurus) (aka complement c5a receptor 1)
C: c5r1 (homo sapiens) (aka complement c5a receptor 1)
D: c5ar (mus musculus) (aka complement component 5a receptor 1)
E: c5ar1 (sus scrofa) (aka comple... | [C] |
<Instruct>: Given the context 'Cell-cell adhesion mediated by binding of membrane-anchored ligand LERK-2 to the EPH-related receptor human embryonal kinase 2 promotes tyrosine kinase activity.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [lerk-2; eph-related receptor human embryonal kinase 2]
<Options>: A: lerk-4 (homo sapiens) (aka ephrin a4)
B: lerk-6 (homo sapiens) (aka ephrin a2)
C: lerk7 (homo sapiens) (aka ephrin a5)
D: erk (homo sapiens) (eph receptor b2 (homo sapiens)) (aka eph receptor b2)
E: ek2 (homo sapiens) (aka eph receptor b3... | [H; E] |
<Instruct>: Given the context 'Cell-cell adhesion mediated by binding of membrane-anchored ligand LERK-2 to the EPH-related receptor human embryonal kinase 2 promotes tyrosine kinase activity.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [lerk-2; eph-related receptor human embryonal kinase 2]
<Options>: A: epht2 (homo sapiens) (aka eph receptor b1)
B: lerk2 (homo sapiens) (aka ephrin b1)
C: lerk4 (homo sapiens) (aka ephrin a4)
D: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
E: ephrin-b2 (homo sapiens) (aka ephrin b2)
F: ek2 (hom... | [B; F] |
<Instruct>: Given the context 'Human embryonal kinase 2 (HEK2) is a protein-tyrosine kinase that is a member of the EPH family of receptors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [embryonal kinase 2; hek2]
<Options>: A: etnk2 (homo sapiens) (aka ethanolamine kinase 2)
B: epht2 (homo sapiens) (aka eph receptor b1)
C: ehk-2 (homo sapiens) (aka eph receptor a6)
D: eph receptor b2 (homo sapiens) (aka eph receptor b2)
E: erb-b2 receptor tyrosine kinase 2 (gallus gallus) (aka erb-b2 recep... | [H; H] |
<Instruct>: Given the context 'Human embryonal kinase 2 (HEK2) is a protein-tyrosine kinase that is a member of the EPH family of receptors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [embryonal kinase 2; hek2]
<Options>: A: etk2 (homo sapiens) (aka eph receptor b3)
B: hek7 (homo sapiens) (aka eph receptor a5)
C: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
D: eph receptor b2 (homo sapiens) (aka eph receptor b2)
E: etk-2 (mus musculus) (aka tyro3 protein tyrosine kinase 3)
F:... | [A; A] |
<Instruct>: Given the context 'Transcripts for HEK2 have a wide tissue distribution.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hek2]
<Options>: A: hek (homo sapiens) (aka eph receptor a3)
B: hek3 (homo sapiens) (aka eph receptor a8)
C: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
D: epht2 (homo sapiens) (aka eph receptor b1)
E: hek2 (homo sapiens) (aka eph receptor b3)
F: None of the above. | [E] |
<Instruct>: Given the context 'In order to analyze functional effects between the LERKs and the HEK2 receptor, we expressed HEK2 cDNA in an interleukin-3-dependent progenitor cell line 32D that grows as single cells in culture.', select the correct biomedical concept for each mention using the provided options. Answer ... | <Mentions>: [hek2; interleukin-3]
<Options>: A: il-3 (homo sapiens) (aka interleukin 3)
B: hek (homo sapiens) (aka eph receptor a3)
C: interleukin 7 (homo sapiens) (aka interleukin 7)
D: il-2 (homo sapiens) (aka interleukin 2)
E: hek3 (homo sapiens) (aka eph receptor a8)
F: interleukin 5 (homo sapiens) (aka interleukin... | [I; A] |
<Instruct>: Given the context 'In order to analyze functional effects between the LERKs and the HEK2 receptor, we expressed HEK2 cDNA in an interleukin-3-dependent progenitor cell line 32D that grows as single cells in culture.', select the correct biomedical concept for each mention using the provided options. Answer ... | <Mentions>: [hek2; interleukin-3]
<Options>: A: hek2 (homo sapiens) (aka eph receptor b3)
B: eph receptor b2 (homo sapiens) (aka eph receptor b2)
C: epht2 (homo sapiens) (aka eph receptor b1)
D: interleukin 5 (homo sapiens) (aka interleukin 5)
E: hek7 (homo sapiens) (aka eph receptor a5)
F: interleukin 7 (homo sapiens)... | [A; J] |
<Instruct>: Given the context 'Within the group of LERKs, LERK-2 and -5 were shown to bind to HEK2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hek2]
<Options>: A: hek (homo sapiens) (aka eph receptor a3)
B: hek2 (homo sapiens) (aka eph receptor b3)
C: epht2 (homo sapiens) (aka eph receptor b1)
D: ehk-2 (homo sapiens) (aka eph receptor a6)
E: hek7 (homo sapiens) (aka eph receptor a5)
F: None of the above. | [B] |
<Instruct>: Given the context 'Membrane-bound and soluble forms of LERK-2 were demonstrated to signal through HEK2 as judged by receptor phosphorylation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [lerk-2; hek2]
<Options>: A: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
B: hek2 (homo sapiens) (aka eph receptor b3)
C: lerk-1 (homo sapiens) (aka ephrin a1)
D: lerk2 (homo sapiens) (aka ephrin b1)
E: hek3 (homo sapiens) (aka eph receptor a8)
F: epht2 (homo sapiens) (aka eph receptor b1)
G: le... | [D; B] |
<Instruct>: Given the context 'Membrane-bound and soluble forms of LERK-2 were demonstrated to signal through HEK2 as judged by receptor phosphorylation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [lerk-2; hek2]
<Options>: A: lerk7 (homo sapiens) (aka ephrin a5)
B: hek3 (homo sapiens) (aka eph receptor a8)
C: eph receptor b2 (homo sapiens) (aka eph receptor b2)
D: lerk-6 (homo sapiens) (aka ephrin a2)
E: hek2 (homo sapiens) (aka eph receptor b3)
F: lerk-1 (homo sapiens) (aka ephrin a1)
G: hek (homo s... | [J; E] |
<Instruct>: Given the context 'Coincubation of HEK2 and LERK-2 expressing cells induced cell-cell adhesion and formation of cell aggregates.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hek2; lerk-2]
<Options>: A: lerk-2 (xenopus laevis) (aka ephrin-b1 l homeolog)
B: hek2 (homo sapiens) (aka eph receptor b3)
C: lerk2 (homo sapiens) (aka ephrin b1)
D: lerk-6 (homo sapiens) (aka ephrin a2)
E: hek3 (homo sapiens) (aka eph receptor a8)
F: lerk7 (homo sapiens) (aka ephrin a5)
G: etk-2 (homo sa... | [B; C] |
<Instruct>: Given the context 'Coincubation of HEK2 and LERK-2 expressing cells induced cell-cell adhesion and formation of cell aggregates.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hek2; lerk-2]
<Options>: A: lerk7 (homo sapiens) (aka ephrin a5)
B: ehk-2 (homo sapiens) (aka eph receptor a6)
C: lerk2 (homo sapiens) (aka ephrin b1)
D: epht2 (homo sapiens) (aka eph receptor b1)
E: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
F: hek2 (homo sapiens) (aka eph receptor b3)
G: he... | [F; C] |
<Instruct>: Given the context 'This interaction could be inhibited by preincubation of HEK2 expressing cells with soluble LERK-2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hek2; lerk-2]
<Options>: A: lerk4 (homo sapiens) (aka ephrin a4)
B: hek (homo sapiens) (aka eph receptor a3)
C: ephrin-b2 (homo sapiens) (aka ephrin b2)
D: epht2 (homo sapiens) (aka eph receptor b1)
E: lerk-6 (homo sapiens) (aka ephrin a2)
F: hek7 (homo sapiens) (aka eph receptor a5)
G: ek2 (homo sapiens) ... | [G; J] |
<Instruct>: Given the context 'This interaction could be inhibited by preincubation of HEK2 expressing cells with soluble LERK-2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hek2; lerk-2]
<Options>: A: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
B: lerk2 (homo sapiens) (aka ephrin b1)
C: lerk4 (homo sapiens) (aka ephrin a4)
D: lerk-6 (homo sapiens) (aka ephrin a2)
E: lerk-2 (xenopus laevis) (aka ephrin-b1 l homeolog)
F: lerk5 (homo sapiens) (aka ephrin b2)
G: epht... | [H; B] |
<Instruct>: Given the context 'Coexpression of HEK2 and LERK-2 in 32D cells showed reduced kinase activity and autophosphorylation of HEK2 compared with the juxtacrine stimulation, which seems to be due to a reduced sensitivity of the receptor.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [hek2; lerk-2]
<Options>: A: hek3 (homo sapiens) (aka eph receptor a8)
B: hek (homo sapiens) (aka eph receptor a3)
C: lerk2 (homo sapiens) (aka ephrin b1)
D: epht2 (homo sapiens) (aka eph receptor b1)
E: lerk-2 (xenopus laevis) (aka ephrin-b1 l homeolog)
F: lerk-6 (homo sapiens) (aka ephrin a2)
G: hek7 (hom... | [H; C] |
<Instruct>: Given the context 'Coexpression of HEK2 and LERK-2 in 32D cells showed reduced kinase activity and autophosphorylation of HEK2 compared with the juxtacrine stimulation, which seems to be due to a reduced sensitivity of the receptor.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [hek2; lerk-2]
<Options>: A: hek (homo sapiens) (aka eph receptor a3)
B: lerk5 (homo sapiens) (aka ephrin b2)
C: lerk-6 (homo sapiens) (aka ephrin a2)
D: lerk7 (homo sapiens) (aka ephrin a5)
E: hek3 (homo sapiens) (aka eph receptor a8)
F: lerk1 (homo sapiens) (aka ephrin a1)
G: ehk-2 (homo sapiens) (aka eph... | [I; J] |
<Instruct>: Given the context 'Expression of the receptor protein tyrosine kinase myk-1/htk in normal and malignant mammary epithelium.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [myk-1; htk]
<Options>: A: mitogen-activated protein kinase kinase 1 (mus musculus) (aka mitogen-activated protein kinase kinase 1)
B: htpk1 (homo sapiens) (aka thiamin pyrophosphokinase 1)
C: mitogen-activated protein kinase kinase kinase 1 (mus musculus) (aka mitogen-activated protein kinase kinase kinase... | [F; F] |
<Instruct>: Given the context 'Expression of the receptor protein tyrosine kinase myk-1/htk in normal and malignant mammary epithelium.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [myk-1; htk]
<Options>: A: mymk (homo sapiens) (aka myomaker, myoblast fusion factor)
B: ptk (homo sapiens) (aka protein tyrosine kinase 2 beta)
C: bmk-1 (mus musculus) (aka mitogen-activated protein kinase 7)
D: htk-l (homo sapiens) (aka ephrin b2)
E: myk1 (homo sapiens) (aka eph receptor b4)
F: ttk (homo ... | [E; E] |
<Instruct>: Given the context 'We have recently reported the molecular characterization of a novel murine receptor PTK (myk-1), belonging to the eph-related family, whose expression was differentially regulated during mammary gland development and elevated in invasive mouse mammary tumours.', select the correct biomedi... | <Mentions>: [myk-1]
<Options>: A: mbk1 (homo sapiens) (aka potassium voltage-gated channel subfamily a member 1)
B: mitogen-activated protein kinase kinase kinase kinase 1 (homo sapiens) (aka mitogen-activated protein kinase kinase kinase kinase 1)
C: mitogen-activated protein kinase kinase kinase 1 (mus musculus) (aka... | [E] |
<Instruct>: Given the context 'We have recently reported the molecular characterization of a novel murine receptor PTK (myk-1), belonging to the eph-related family, whose expression was differentially regulated during mammary gland development and elevated in invasive mouse mammary tumours.', select the correct biomedi... | <Mentions>: [myk-1]
<Options>: A: mitogen-activated protein kinase kinase kinase kinase 1 (homo sapiens) (aka mitogen-activated protein kinase kinase kinase kinase 1)
B: mitogen-activated protein kinase kinase kinase 1 (mus musculus) (aka mitogen-activated protein kinase kinase kinase 1)
C: mbk1 (homo sapiens) (aka pot... | [E] |
<Instruct>: Given the context 'In this communication we have investigated the cellular origin of myk-1 expression by in situ hybridisation and RNase protection.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [myk-1]
<Options>: A: prkmk1 (homo sapiens) (aka mitogen-activated protein kinase kinase 1)
B: myk1 (mus musculus) (aka eph receptor b4)
C: mitogen-activated protein kinase kinase 1 (mus musculus) (aka mitogen-activated protein kinase kinase 1)
D: myk1 (homo sapiens) (aka eph receptor b4)
E: bmk-1 (mus musc... | [D] |
<Instruct>: Given the context 'Murine antisense myk-1 probe specifically recognised ductal and alveolar epithelium in the resting mouse mammary gland.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [myk-1]
<Options>: A: bmk-1 (mus musculus) (aka mitogen-activated protein kinase 7)
B: mitogen-activated protein kinase kinase kinase kinase 1 (homo sapiens) (aka mitogen-activated protein kinase kinase kinase kinase 1)
C: myk1 (mus musculus) (aka eph receptor b4)
D: mitogen-activated protein kinase kinase ... | [E] |
<Instruct>: Given the context 'In normal human breast, the expression of htk, the human homologue, was also confined to the secretory luminal epithelial cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by ... | <Mentions>: [htk]
<Options>: A: htk (homo sapiens) (aka eph receptor b4)
B: tpk1 (homo sapiens) (aka thiamin pyrophosphokinase 1)
C: ctk (homo sapiens) (aka megakaryocyte-associated tyrosine kinase)
D: atk (homo sapiens) (aka bruton tyrosine kinase)
E: ptk (homo sapiens) (aka protein tyrosine kinase 2 beta)
F: None of ... | [A] |
<Instruct>: Given the context 'Elevated expression of htk was found in several human breast carcinoma cell lines as well as in primary, high grade, infiltrating, ductal carcinomas of the breast.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [htk]
<Options>: A: tpk1 (homo sapiens) (aka thiamin pyrophosphokinase 1)
B: ttk protein kinase (homo sapiens) (aka ttk protein kinase)
C: htk (homo sapiens) (aka eph receptor b4)
D: ptk (homo sapiens) (aka protein tyrosine kinase 2 beta)
E: htk-l (homo sapiens) (aka ephrin b2)
F: None of the above. | [C] |
<Instruct>: Given the context 'The specific epithelial expression of the myk-1/htk receptor PTK suggest a specialised role of this eph-related PTK in the differentiation and/or maintenance of secretory epithelium in the adult.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [myk-1; htk]
<Options>: A: mitogen-activated protein kinase kinase 1 (mus musculus) (aka mitogen-activated protein kinase kinase 1)
B: tpk1 (homo sapiens) (aka thiamin pyrophosphokinase 1)
C: myk1 (homo sapiens) (aka eph receptor b4)
D: ttk (homo sapiens) (aka ttk protein kinase)
E: myk1 (mus musculus) (aka... | [C; C] |
<Instruct>: Given the context 'The specific epithelial expression of the myk-1/htk receptor PTK suggest a specialised role of this eph-related PTK in the differentiation and/or maintenance of secretory epithelium in the adult.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [myk-1; htk]
<Options>: A: mitogen-activated protein kinase kinase kinase 1 (mus musculus) (aka mitogen-activated protein kinase kinase kinase 1)
B: ctk (homo sapiens) (aka megakaryocyte-associated tyrosine kinase)
C: htpk1 (homo sapiens) (aka thiamin pyrophosphokinase 1)
D: bmk-1 (mus musculus) (aka mitoge... | [H; H] |
<Instruct>: Given the context 'Cloning and characterization of a novel human clathrin heavy chain gene (CLTCL).
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cltcl]
<Options>: A: chloride channel clic-like 1 (xenopus tropicalis) (aka chloride channel clic-like 1)
B: cltcl (homo sapiens) (aka clathrin heavy chain like 1)
C: chloride channel clic like 1 (bos taurus) (aka chloride channel clic like 1)
D: chloride channel clic like 1 (homo sapiens) (aka chloride ch... | [B] |
<Instruct>: Given the context 'An exon representing a novel clathrin heavy chain gene (CLTCL) was isolated during gene identification studies and transcription mapping of human chromosome 22.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one... | <Mentions>: [cltcl]
<Options>: A: chloride channel clic like 1 (homo sapiens) (aka chloride channel clic like 1)
B: chloride channel clic like 1 (bos taurus) (aka chloride channel clic like 1)
C: cltcl (homo sapiens) (aka clathrin heavy chain like 1)
D: cltcl1.l (xenopus laevis) (aka clathrin heavy chain like 1 l homeo... | [C] |
<Instruct>: Given the context 'An exon representing a novel clathrin heavy chain gene (CLTCL) was isolated during gene identification studies and transcription mapping of human chromosome 22.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one... | <Mentions>: [cltcl]
<Options>: A: chloride channel clic like 1 (homo sapiens) (aka chloride channel clic like 1)
B: cltcl1 (oryctolagus cuniculus) (aka clathrin heavy chain like 1)
C: cltcl1.l (xenopus laevis) (aka clathrin heavy chain like 1 l homeolog)
D: chloride channel clic like 1 (bos taurus) (aka chloride channe... | [E] |
<Instruct>: Given the context 'The location of CLTCL on human chromosome 22 near the region commonly deleted in DiGeorge and other apparent haploinsufficiency syndromes warrants further investigation into its relationship with these developmental disorders.', select the correct biomedical concept for each mention using... | <Mentions>: [cltcl]
<Options>: A: chloride channel clic like 1 (homo sapiens) (aka chloride channel clic like 1)
B: cltcl1 (homo sapiens) (aka clathrin heavy chain like 1)
C: cltcl1 (oryctolagus cuniculus) (aka clathrin heavy chain like 1)
D: cltc.l (xenopus laevis) (aka clathrin, heavy chain (hc) l homeolog)
E: chlori... | [B] |
<Instruct>: Given the context 'Here, we report the isolation of two Na+/Pi cotransporter cDNAs (RNaPi-1a and RNaPi-1b) from a rat liver cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rnapi-1a; rnapi-1b]
<Options>: A: rpb11b1 (homo sapiens) (aka rna polymerase ii subunit j2)
B: rna polymerase i subunit h (homo sapiens) (aka rna polymerase i subunit h)
C: protein phosphatase 1 regulatory inhibitor subunit 1a (homo sapiens) (aka protein phosphatase 1 regulatory inhibitor subunit 1a)
D: rn... | [J; J] |
<Instruct>: Given the context 'Here, we report the isolation of two Na+/Pi cotransporter cDNAs (RNaPi-1a and RNaPi-1b) from a rat liver cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rnapi-1a; rnapi-1b]
<Options>: A: polr2i (homo sapiens) (aka rna polymerase ii subunit i)
B: rna polymerase i subunit a (homo sapiens) (aka rna polymerase i subunit a)
C: rna polymerase i subunit h (homo sapiens) (aka rna polymerase i subunit h)
D: rna polymerase i subunit b (homo sapiens) (aka rna polymer... | [K; K] |
<Instruct>: Given the context 'The rat cDNAs encode a polypeptide of 465 amino acids, having 62% and 66% identity with the rabbit NaPi-1 and human kidney Na+/Pi cotransporter, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [napi-1; na+/pi cotransporter]
<Options>: A: npat (rattus norvegicus) (aka nuclear protein, co-activator of histone transcription)
B: napi-1 (homo sapiens) (aka solute carrier family 17 member 1)
C: na/pi-cotransporter (drosophila melanogaster) (aka na[+]-dependent inorganic phosphate cotransporter)
D: napi... | [K; F] |
<Instruct>: Given the context 'The rat cDNAs encode a polypeptide of 465 amino acids, having 62% and 66% identity with the rabbit NaPi-1 and human kidney Na+/Pi cotransporter, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [napi-1; na+/pi cotransporter]
<Options>: A: napi-1 (homo sapiens) (aka solute carrier family 17 member 1)
B: nipp-1 (homo sapiens) (aka protein phosphatase 1 regulatory subunit 8)
C: napi-1 (rattus norvegicus) (aka solute carrier family 17 member 1)
D: npat (rattus norvegicus) (aka nuclear protein, co-acti... | [K; J] |
<Instruct>: Given the context 'Northern blot analysis showed that a RNaPi-1a--specific probe detected two major transcripts (2.3 and 1.8 kb), whereas a RNaPi-1b--specific probe hybridized with one transcript (1.8 kb) in rat kidney, liver, and hepatocytes in primary culture.', select the correct biomedical concept for e... | <Mentions>: [rnapi-1a; rnapi-1b]
<Options>: A: rna polymerase ii subunit b (homo sapiens) (aka rna polymerase ii subunit b)
B: rna polymerase i subunit a (homo sapiens) (aka rna polymerase i subunit a)
C: rna polymerase i subunit b (homo sapiens) (aka rna polymerase i subunit b)
D: rna polymerase ii subunit i (homo sap... | [I; I] |
<Instruct>: Given the context 'Northern blot analysis showed that a RNaPi-1a--specific probe detected two major transcripts (2.3 and 1.8 kb), whereas a RNaPi-1b--specific probe hybridized with one transcript (1.8 kb) in rat kidney, liver, and hepatocytes in primary culture.', select the correct biomedical concept for e... | <Mentions>: [rnapi-1a; rnapi-1b]
<Options>: A: rna polymerase i subunit b (homo sapiens) (aka rna polymerase i subunit b)
B: rpb10beta (homo sapiens) (aka rna polymerase ii, i and iii subunit l)
C: rpb11b1 (homo sapiens) (aka rna polymerase ii subunit j2)
D: protein phosphatase 1 regulatory inhibitor subunit 1a (homo s... | [K; K] |
<Instruct>: Given the context 'Rat liver expressed much higher levels of RNaPi-1a than RNaPi-1b, whereas the converse was true for rat kidney.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rnapi-1a; rnapi-1b]
<Options>: A: rna polymerase ii subunit i (homo sapiens) (aka rna polymerase ii subunit i)
B: rpb10beta (homo sapiens) (aka rna polymerase ii, i and iii subunit l)
C: rna polymerase ii subunit b (homo sapiens) (aka rna polymerase ii subunit b)
D: rii-beta (homo sapiens) (aka protein kin... | [K; K] |
<Instruct>: Given the context 'Rat liver expressed much higher levels of RNaPi-1a than RNaPi-1b, whereas the converse was true for rat kidney.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rnapi-1a; rnapi-1b]
<Options>: A: rna polymerase i subunit g (homo sapiens) (aka rna polymerase i subunit g)
B: rii-beta (homo sapiens) (aka protein kinase camp-dependent type ii regulatory subunit beta)
C: rna polymerase i subunit h (homo sapiens) (aka rna polymerase i subunit h)
D: protein phosphatase 1 ... | [K; K] |
<Instruct>: Given the context 'These findings indicate that there are at least two isoforms of RNaPi-1 transcripts expressed in liver and kidney and that the levels of expression of the RNaPi-1a and RNaPi-1b may be controlled by tissue-specific factors.', select the correct biomedical concept for each mention using the... | <Mentions>: [rnapi-1a; rnapi-1b]
<Options>: A: protein phosphatase 1 regulatory inhibitor subunit 1b (homo sapiens) (aka protein phosphatase 1 regulatory inhibitor subunit 1b)
B: polr1b (homo sapiens) (aka rna polymerase i subunit b)
C: rna polymerase ii subunit i (homo sapiens) (aka rna polymerase ii subunit i)
D: pol... | [K; K] |
<Instruct>: Given the context 'These findings indicate that there are at least two isoforms of RNaPi-1 transcripts expressed in liver and kidney and that the levels of expression of the RNaPi-1a and RNaPi-1b may be controlled by tissue-specific factors.', select the correct biomedical concept for each mention using the... | <Mentions>: [rnapi-1a; rnapi-1b]
<Options>: A: rna polymerase i subunit b (homo sapiens) (aka rna polymerase i subunit b)
B: rna polymerase i subunit a (homo sapiens) (aka rna polymerase i subunit a)
C: rpi1p (saccharomyces cerevisiae s288c) (aka rpi1p)
D: protein phosphatase 1 regulatory inhibitor subunit 1b (homo sap... | [K; K] |
<Instruct>: Given the context 'Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells.
p50csk is a tyrosine protein kinase (TPK) that represses the activity of Src family TPKs.', select the correct biomedical concept for each mention using t... | <Mentions>: [p50csk; pep]
<Options>: A: pep6 (saccharomyces cerevisiae s288c) (aka corvet complex subunit vps3)
B: cask (homo sapiens) (aka calcium/calmodulin dependent serine protein kinase)
C: pep4 (saccharomyces cerevisiae s288c) (aka proteinase a)
D: prkcsh (homo sapiens) (aka prkcsh beta subunit of glucosidase ii)... | [H; G] |
<Instruct>: Given the context 'Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells.
p50csk is a tyrosine protein kinase (TPK) that represses the activity of Src family TPKs.', select the correct biomedical concept for each mention using t... | <Mentions>: [p50csk; pep]
<Options>: A: p50csk (mus musculus) (aka c-src tyrosine kinase)
B: pep6 (saccharomyces cerevisiae s288c) (aka corvet complex subunit vps3)
C: pep1 (saccharomyces cerevisiae s288c) (aka type i sorting receptor)
D: pepe (homo sapiens) (aka peptidase e)
E: csk (homo sapiens) (aka c-terminal src k... | [E; F] |
<Instruct>: Given the context 'We previously showed that Csk is a potent negative regulator of antigen receptor signaling in T lymphocytes and that its Src homology (SH) 3 and SH2 domains are required to inhibit these signals.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [csk]
<Options>: A: serine/threonine protein kinase cbk1 (saccharomyces cerevisiae s288c) (aka serine/threonine protein kinase cbk1)
B: csk (drosophila melanogaster) (costakink (drosophila melanogaster)) (aka costakink)
C: csk (mus musculus) (aka c-src tyrosine kinase)
D: cask (homo sapiens) (aka calcium/ca... | [E] |
<Instruct>: Given the context 'To test the idea that the Csk SH3 and SH2 domains mediate interactions with other cellular proteins, we attempted to identify Csk-associated polypeptides using the yeast two-hybrid system.', select the correct biomedical concept for each mention using the provided options. Answer by listi... | <Mentions>: [csk]
<Options>: A: csk (xenopus laevis) (c-terminal src kinase l homeolog (xenopus laevis)) (aka c-terminal src kinase l homeolog)
B: serine/threonine protein kinase cbk1 (saccharomyces cerevisiae s288c) (aka serine/threonine protein kinase cbk1)
C: cask (homo sapiens) (aka calcium/calmodulin dependent ser... | [E] |
<Instruct>: Given the context 'The results of our experiments demonstrated that Csk physically associates with PEP, a protein tyrosine phosphatase (PTP) expressed in hemopoietic cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [csk; pep]
<Options>: A: csk (homo sapiens) (aka c-terminal src kinase)
B: csk (xenopus laevis) (c-terminal src kinase l homeolog (xenopus laevis)) (aka c-terminal src kinase l homeolog)
C: pep4 (saccharomyces cerevisiae s288c) (aka proteinase a)
D: pep.5 (homo sapiens) (aka protein tyrosine phosphatase non... | [A; D] |
<Instruct>: Given the context 'The results of our experiments demonstrated that Csk physically associates with PEP, a protein tyrosine phosphatase (PTP) expressed in hemopoietic cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [csk; pep]
<Options>: A: pepe (homo sapiens) (aka peptidase e)
B: pep1 (saccharomyces cerevisiae s288c) (aka type i sorting receptor)
C: csk (drosophila melanogaster) (costakink (drosophila melanogaster)) (aka costakink)
D: pepa (homo sapiens) (aka carnosine dipeptidase 2)
E: csk (homo sapiens) (aka c-termi... | [E; J] |
<Instruct>: Given the context 'Further analyses revealed that this interaction was mediated by the Csk SH3 domain and by a proline-rich region (PPPLPERTP) in the non-catalytic C-terminal portion of PEP.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected o... | <Mentions>: [csk; pep]
<Options>: A: csk (drosophila melanogaster) (costakink (drosophila melanogaster)) (aka costakink)
B: pepa (homo sapiens) (aka carnosine dipeptidase 2)
C: csk (xenopus laevis) (c-terminal src kinase s homeolog (xenopus laevis)) (aka c-terminal src kinase s homeolog)
D: csk (homo sapiens) (aka c-te... | [D; F] |
<Instruct>: Given the context 'Further analyses revealed that this interaction was mediated by the Csk SH3 domain and by a proline-rich region (PPPLPERTP) in the non-catalytic C-terminal portion of PEP.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected o... | <Mentions>: [csk; pep]
<Options>: A: pep.5 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 22)
B: serine/threonine protein kinase cbk1 (saccharomyces cerevisiae s288c) (aka serine/threonine protein kinase cbk1)
C: csk (xenopus laevis) (c-terminal src kinase l homeolog (xenopus laevis)) (aka c-termina... | [D; A] |
<Instruct>: Given the context 'The association between Csk and PEP was documented in transiently transfected Cos-1 cells and in a variety of cells of hemopoietic lineages, including T cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one ... | <Mentions>: [csk; pep]
<Options>: A: pep6 (saccharomyces cerevisiae s288c) (aka corvet complex subunit vps3)
B: sck (homo sapiens) (aka shc adaptor protein 2)
C: pepa (homo sapiens) (aka carnosine dipeptidase 2)
D: csk (homo sapiens) (aka c-terminal src kinase)
E: csk (xenopus laevis) (c-terminal src kinase l homeolog ... | [D; J] |
<Instruct>: Given the context 'The association between Csk and PEP was documented in transiently transfected Cos-1 cells and in a variety of cells of hemopoietic lineages, including T cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one ... | <Mentions>: [csk; pep]
<Options>: A: csk (homo sapiens) (aka c-terminal src kinase)
B: hck proto-oncogene, src family tyrosine kinase (homo sapiens) (aka hck proto-oncogene, src family tyrosine kinase)
C: pep1 (saccharomyces cerevisiae s288c) (aka type i sorting receptor)
D: peps (homo sapiens) (aka leucine aminopeptid... | [A; J] |
<Instruct>: Given the context 'Additional analyses demonstrated that the association between Csk and PEP is highly specific.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [csk; pep]
<Options>: A: csk (xenopus laevis) (c-terminal src kinase l homeolog (xenopus laevis)) (aka c-terminal src kinase l homeolog)
B: pepe (homo sapiens) (aka peptidase e)
C: pep4 (saccharomyces cerevisiae s288c) (aka proteinase a)
D: csk (drosophila melanogaster) (costakink (drosophila melanogaster))... | [H; I] |
<Instruct>: Given the context 'Additional analyses demonstrated that the association between Csk and PEP is highly specific.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [csk; pep]
<Options>: A: pepe (homo sapiens) (aka peptidase e)
B: hck proto-oncogene, src family tyrosine kinase (homo sapiens) (aka hck proto-oncogene, src family tyrosine kinase)
C: sck (homo sapiens) (aka shc adaptor protein 2)
D: csk (drosophila melanogaster) (costakink (drosophila melanogaster)) (aka c... | [F; E] |
<Instruct>: Given the context 'Together, these data indicated that PEP may be an effector and/or a regulator of p50csk in T cells and other hemopoietic cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by s... | <Mentions>: [pep; p50csk]
<Options>: A: pep.5 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 22)
B: pep5 (homo sapiens) (aka vps11 core subunit of corvet and hops complexes)
C: csk (homo sapiens) (aka c-terminal src kinase)
D: s6kb (homo sapiens) (aka ribosomal protein s6 kinase b2)
E: pepa (homo sa... | [A; C] |
<Instruct>: Given the context 'Together, these data indicated that PEP may be an effector and/or a regulator of p50csk in T cells and other hemopoietic cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by s... | <Mentions>: [pep; p50csk]
<Options>: A: pep.5 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 22)
B: pep1 (saccharomyces cerevisiae s288c) (aka type i sorting receptor)
C: cask (homo sapiens) (aka calcium/calmodulin dependent serine protein kinase)
D: pepa (homo sapiens) (aka carnosine dipeptidase 2)... | [A; F] |
<Instruct>: Given the context 'Moreover, they allowed the identification of PEP as the first known ligand for the Csk SH3 domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pep; csk]
<Options>: A: csk (mus musculus) (aka c-src tyrosine kinase)
B: pep5 (homo sapiens) (aka vps11 core subunit of corvet and hops complexes)
C: csk (xenopus laevis) (c-terminal src kinase l homeolog (xenopus laevis)) (aka c-terminal src kinase l homeolog)
D: pep4 (saccharomyces cerevisiae s288c) (ak... | [I; E] |
<Instruct>: Given the context 'Moreover, they allowed the identification of PEP as the first known ligand for the Csk SH3 domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pep; csk]
<Options>: A: hck proto-oncogene, src family tyrosine kinase (homo sapiens) (aka hck proto-oncogene, src family tyrosine kinase)
B: cask (homo sapiens) (aka calcium/calmodulin dependent serine protein kinase)
C: pep.5 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 22)
D: pep4 ... | [C; H] |
<Instruct>: Given the context 'cDNA cloning of human allograft inflammatory factor-1: tissue distribution, cytokine induction, and mRNA expression in injured rat carotid arteries.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each m... | <Mentions>: [allograft inflammatory factor-1]
<Options>: A: il1f1 (homo sapiens) (aka interleukin 1 alpha)
B: allograft inflammatory factor 1 like (homo sapiens) (aka allograft inflammatory factor 1 like)
C: ifnai1 (homo sapiens) (aka interferon induced protein with tetratricopeptide repeats 1)
D: hcinf1 (homo sapiens)... | [E] |
<Instruct>: Given the context 'Allograft Inflammatory Factor-1 (AIF-1), a gene previously reported to be expressed in rat IFN gamma-activated macrophages.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [allograft inflammatory factor-1; aif-1; ifn gamma]
<Options>: A: aif (homo sapiens) (aka apoptosis inducing factor mitochondria associated 1)
B: interferon gamma (oryctolagus cuniculus) (aka interferon gamma)
C: ifng (homo sapiens) (aka interferon gamma)
D: aif family member 2 (homo sapiens) (aka aif famil... | [G; G; O] |
<Instruct>: Given the context 'Allograft Inflammatory Factor-1 (AIF-1), a gene previously reported to be expressed in rat IFN gamma-activated macrophages.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [allograft inflammatory factor-1; aif-1; ifn gamma]
<Options>: A: interferon regulatory factor 1 (homo sapiens) (aka interferon regulatory factor 1)
B: allograft inflammatory factor 1 (homo sapiens) (aka allograft inflammatory factor 1)
C: gmf-gamma (homo sapiens) (aka glia maturation factor gamma)
D: il1f1... | [B; B; O] |
<Instruct>: Given the context 'Allograft Inflammatory Factor-1 (AIF-1), a gene previously reported to be expressed in rat IFN gamma-activated macrophages.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [allograft inflammatory factor-1; aif-1; ifn gamma]
<Options>: A: aif1l (homo sapiens) (aka allograft inflammatory factor 1 like)
B: ifnai1 (homo sapiens) (aka interferon induced protein with tetratricopeptide repeats 1)
C: interferon gamma (xenopus tropicalis) (aka interferon gamma)
D: aifm1 (homo sapiens)... | [N; N; O] |
<Instruct>: Given the context 'This human AIF-1 homologue is inducible in serum and cytokine-stimulated human smooth muscle cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [aif-1]
<Options>: A: aif (homo sapiens) (aka apoptosis inducing factor mitochondria associated 1)
B: aif-1 (homo sapiens) (aka allograft inflammatory factor 1)
C: apaf-1 (homo sapiens) (aka apoptotic peptidase activating factor 1)
D: aif family member 2 (homo sapiens) (aka aif family member 2)
E: aif-1 (mu... | [B] |
<Instruct>: Given the context 'Functional expression of a novel human neurokinin-3 receptor homolog that binds [3H]senktide and [125I-MePhe7]neurokinin B, and is responsive to tachykinin peptide agonists.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selecte... | <Mentions>: [neurokinin-3 receptor; neurokinin b]
<Options>: A: neuromedin b (homo sapiens) (aka neuromedin b)
B: nk2r (homo sapiens) (aka tachykinin receptor 2)
C: tachykinin receptor 3 (rattus norvegicus) (aka tachykinin receptor 3)
D: tachykinin receptor 3 (bos taurus) (aka tachykinin receptor 3)
E: nkb (homo sapien... | [J; E] |
<Instruct>: Given the context 'Functional expression of a novel human neurokinin-3 receptor homolog that binds [3H]senktide and [125I-MePhe7]neurokinin B, and is responsive to tachykinin peptide agonists.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selecte... | <Mentions>: [neurokinin-3 receptor; neurokinin b]
<Options>: A: tachykinin receptor 3 (bos taurus) (aka tachykinin receptor 3)
B: tachykinin receptor 3 (sus scrofa) (aka tachykinin receptor 3)
C: nkb (homo sapiens) (aka tachykinin precursor 3)
D: tachykinin receptor 2 (homo sapiens) (aka tachykinin receptor 2)
E: nk2r ... | [F; C] |
<Instruct>: Given the context 'In 1992, Xie et al. identified a cDNA sequence in the expression cloning search for the kappa opioid receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kappa opioid receptor]
<Options>: A: opioid receptor, kappa 1 (rattus norvegicus) (aka opioid receptor, kappa 1)
B: opioid related nociceptin receptor 1 (homo sapiens) (aka opioid related nociceptin receptor 1)
C: opioid receptor, kappa 1 (mus musculus) (aka opioid receptor, kappa 1)
D: oprk (homo sapiens)... | [D] |
<Instruct>: Given the context 'This cDNA was highly homologous to the human neurokinin-3 (NK-3) receptor sequence, and displayed lower homology to NK-1 and NK-2 sequences.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, s... | <Mentions>: [neurokinin-3 (nk-3) receptor; nk-1; nk-2]
<Options>: A: nkr (homo sapiens) (tachykinin receptor 3 (homo sapiens)) (aka tachykinin receptor 3)
B: tachykinin receptor 2 (rattus norvegicus) (aka tachykinin receptor 2)
C: nk-2 (homo sapiens) (aka nk2 homeobox 1)
D: tachykinin receptor 3 (rattus norvegicus) (ak... | [A; K; G] |
<Instruct>: Given the context 'This cDNA was highly homologous to the human neurokinin-3 (NK-3) receptor sequence, and displayed lower homology to NK-1 and NK-2 sequences.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, s... | <Mentions>: [neurokinin-3 (nk-3) receptor; nk-1; nk-2]
<Options>: A: nkb (homo sapiens) (aka tachykinin precursor 3)
B: nk2r (homo sapiens) (aka tachykinin receptor 2)
C: tachykinin receptor 2 (homo sapiens) (aka tachykinin receptor 2)
D: tachykinin receptor 3 (rattus norvegicus) (aka tachykinin receptor 3)
E: tachykin... | [O; G; C] |
<Instruct>: Given the context 'This cDNA was highly homologous to the human neurokinin-3 (NK-3) receptor sequence, and displayed lower homology to NK-1 and NK-2 sequences.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, s... | <Mentions>: [neurokinin-3 (nk-3) receptor; nk-1; nk-2]
<Options>: A: nk2.3 (homo sapiens) (aka nk2 homeobox 3)
B: nkna (homo sapiens) (aka tachykinin precursor 1)
C: nkr-p1a (homo sapiens) (aka killer cell lectin like receptor b1)
D: tachykinin receptor 2 (homo sapiens) (aka tachykinin receptor 2)
E: nkr (rattus norveg... | [H; M; D] |
<Instruct>: Given the context 'This cDNA was highly homologous to the human neurokinin-3 (NK-3) receptor sequence, and displayed lower homology to NK-1 and NK-2 sequences.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, s... | <Mentions>: [neurokinin-3 (nk-3) receptor; nk-1; nk-2]
<Options>: A: nkr-p1 (homo sapiens) (aka killer cell lectin like receptor b1)
B: tachykinin receptor 3 (rattus norvegicus) (aka tachykinin receptor 3)
C: tachykinin receptor 3 (bos taurus) (aka tachykinin receptor 3)
D: nk3r (homo sapiens) (aka tachykinin receptor ... | [K; L; J] |
<Instruct>: Given the context 'This sequence was stably expressed in Chinese hamster ovary cells, which do not express neurokinin receptors naturally, and ligand binding and second messenger characteristics were compared with a human NK-3 receptor.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [nk-3 receptor]
<Options>: A: nk2r (homo sapiens) (aka tachykinin receptor 2)
B: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
C: tac3r (homo sapiens) (aka tachykinin receptor 3)
D: tachykinin receptor 3 (xenopus tropicalis) (aka tachykinin receptor 3)
E: tachykinin receptor 3 (rat... | [C] |
<Instruct>: Given the context 'The NK-3 receptor homolog bound [3H] senktide with a Kd of 39 nM, similar to that of the NK-3 receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nk-3 receptor]
<Options>: A: nk2r (homo sapiens) (aka tachykinin receptor 2)
B: tachykinin receptor 3 (rattus norvegicus) (aka tachykinin receptor 3)
C: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
D: nk3r (mus musculus) (aka tachykinin receptor 3)
E: tac3r (homo sapiens) (aka ta... | [E] |
<Instruct>: Given the context 'The rank order of tachykinin peptides competing for [3H]senktide binding at the NK-3 receptor homolog was [MePhe7]neurokinin B > senktide > substance P = neurokinin A > neurokinin B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [nk-3 receptor; neurokinin b; substance p; neurokinin a]
<Options>: A: tachykinin precursor 1 (sus scrofa) (aka tachykinin precursor 1)
B: nknb (homo sapiens) (aka tachykinin precursor 3)
C: tachykinin receptor 3 (rattus norvegicus) (aka tachykinin receptor 3)
D: neuromedin b (homo sapiens) (aka neuromedin ... | [Q; B; L; L] |
<Instruct>: Given the context 'The rank order of tachykinin peptides competing for [3H]senktide binding at the NK-3 receptor homolog was [MePhe7]neurokinin B > senktide > substance P = neurokinin A > neurokinin B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [nk-3 receptor; neurokinin b; substance p; neurokinin a]
<Options>: A: nk3r (mus musculus) (aka tachykinin receptor 3)
B: tachykinin, precursor 1 (rattus norvegicus) (aka tachykinin, precursor 1)
C: nk2r (homo sapiens) (aka tachykinin receptor 2)
D: nknb (homo sapiens) (aka tachykinin precursor 3)
E: neurom... | [F; D; L; L] |
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