instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Disruption of NAS1 resulted in several phenotypes, including lethality and temperature-sensitive growth, depending on the genetic background of the cells used.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nas1]
<Options>: A: nas1 (xenopus tropicalis) (aka solute carrier family 13 member 1)
B: nas1 (arabidopsis thaliana) (aka nicotianamine synthase 1)
C: nas1 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle base subunit rpn1)
D: anorexia nervosa, susceptibility to, 1 (homo sapiens) (aka anorexia nervosa, susceptibility to, 1)
E: nas1 (homo sapiens) (nr2f1 regulatory antisense rna 1 (homo sapiens)) (aka nr2f1 regulatory antisense rna 1)
F: None of the above. | [C] |
<Instruct>: Given the context 'The human p97 cDNA suppressed the growth defect of nas1 disruptant cells, when expressed from single-copy or multi-copy vectors, indicating that p97 is functionally equivalent to yeast Nas1p.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p97; nas1p]
<Options>: A: nas1 (xenopus laevis) (solute carrier family 13 member 1 s homeolog (xenopus laevis)) (aka solute carrier family 13 member 1 s homeolog)
B: nas7 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle lid subunit rpn9)
C: ec97 (homo sapiens) (aka vps35 endosomal protein sorting factor like)
D: nas5 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle lid subunit rpn5)
E: nas1 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle base subunit rpn1)
F: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
G: p97 (drosophila melanogaster) (transitional endoplasmic reticulum 94 (drosophila melanogaster)) (aka transitional endoplasmic reticulum 94)
H: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
I: p97 (homo sapiens) (valosin containing protein (homo sapiens)) (aka valosin containing protein)
J: nasp (homo sapiens) (aka nuclear autoantigenic sperm protein)
K: None of the above. | [H; E] |
<Instruct>: Given the context 'The human p97 cDNA suppressed the growth defect of nas1 disruptant cells, when expressed from single-copy or multi-copy vectors, indicating that p97 is functionally equivalent to yeast Nas1p.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p97; nas1p]
<Options>: A: nas1 (arabidopsis thaliana) (aka nicotianamine synthase 1)
B: nas1 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle base subunit rpn1)
C: nas6p (saccharomyces cerevisiae s288c) (aka nas6p)
D: hspc197 (homo sapiens) (aka bet1 golgi vesicular membrane trafficking protein like)
E: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
F: nas7 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle lid subunit rpn9)
G: map97 (homo sapiens) (aka melanotransferrin)
H: nas1 (xenopus laevis) (solute carrier family 13 member 1 s homeolog (xenopus laevis)) (aka solute carrier family 13 member 1 s homeolog)
I: p97 (bos taurus) (aka valosin containing protein)
J: ec97 (homo sapiens) (aka vps35 endosomal protein sorting factor like)
K: None of the above. | [E; B] |
<Instruct>: Given the context 'Culturing of the temperature-sensitive nas1 cells at the restrictive temperature promoted the accumulation polyubiquitinated cellular proteins, implying that the 26S proteasome requires a functional Nas1p subunit for ubiquitin-dependent proteolysis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nas1p]
<Options>: A: nas1 (xenopus tropicalis) (aka solute carrier family 13 member 1)
B: nas1 (xenopus laevis) (solute carrier family 13 member 1 s homeolog (xenopus laevis)) (aka solute carrier family 13 member 1 s homeolog)
C: nas6p (saccharomyces cerevisiae s288c) (aka nas6p)
D: nas7 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle lid subunit rpn9)
E: nas1 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle base subunit rpn1)
F: None of the above. | [E] |
<Instruct>: Given the context 'These results indicate that p97/Nas1p plays an important regulatory role in the function of the 26S proteasome.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p97; nas1p]
<Options>: A: nas1 (xenopus tropicalis) (aka solute carrier family 13 member 1)
B: nas1 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle base subunit rpn1)
C: ec97 (homo sapiens) (aka vps35 endosomal protein sorting factor like)
D: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
E: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
F: nas1 (arabidopsis thaliana) (aka nicotianamine synthase 1)
G: p97 (bos taurus) (aka valosin containing protein)
H: nas5 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle lid subunit rpn5)
I: nas7 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle lid subunit rpn9)
J: p97 (drosophila melanogaster) (regulatory particle non-atpase 1 (drosophila melanogaster)) (aka regulatory particle non-atpase 1)
K: None of the above. | [D; B] |
<Instruct>: Given the context 'These results indicate that p97/Nas1p plays an important regulatory role in the function of the 26S proteasome.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p97; nas1p]
<Options>: A: nas1 (xenopus tropicalis) (aka solute carrier family 13 member 1)
B: p97 (drosophila melanogaster) (regulatory particle non-atpase 1 (drosophila melanogaster)) (aka regulatory particle non-atpase 1)
C: nas4 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle lid subunit rpn6)
D: p97 (bos taurus) (aka valosin containing protein)
E: nas7 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle lid subunit rpn9)
F: p97 (homo sapiens) (valosin containing protein (homo sapiens)) (aka valosin containing protein)
G: p97 (drosophila melanogaster) (transitional endoplasmic reticulum 94 (drosophila melanogaster)) (aka transitional endoplasmic reticulum 94)
H: nas5 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle lid subunit rpn5)
I: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
J: nas1 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle base subunit rpn1)
K: None of the above. | [I; J] |
<Instruct>: Given the context 'These results indicate that p97/Nas1p plays an important regulatory role in the function of the 26S proteasome.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p97; nas1p]
<Options>: A: nas4 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle lid subunit rpn6)
B: nas1 (xenopus tropicalis) (aka solute carrier family 13 member 1)
C: p97 (drosophila melanogaster) (regulatory particle non-atpase 1 (drosophila melanogaster)) (aka regulatory particle non-atpase 1)
D: p97 (bos taurus) (aka valosin containing protein)
E: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
F: nas7 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle lid subunit rpn9)
G: p97 (drosophila melanogaster) (transitional endoplasmic reticulum 94 (drosophila melanogaster)) (aka transitional endoplasmic reticulum 94)
H: p97 (homo sapiens) (valosin containing protein (homo sapiens)) (aka valosin containing protein)
I: nas5 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle lid subunit rpn5)
J: None of the above. | [E; J] |
<Instruct>: Given the context 'Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.
Transforming growth factor-beta TGF-beta is the prototype for a family of extracellular proteins that affect cell proliferation and tissue differentiation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tgf-beta; transforming growth factor-beta]
<Options>: A: transforming growth factor beta receptor 3 (homo sapiens) (aka transforming growth factor beta receptor 3)
B: transforming growth factor beta 3 (homo sapiens) (aka transforming growth factor beta 3)
C: transforming growth factor beta 1 (xenopus tropicalis) (aka transforming growth factor beta 1)
D: transforming growth factor beta 2 (homo sapiens) (aka transforming growth factor beta 2)
E: transforming growth factor beta 1 (homo sapiens) (aka transforming growth factor beta 1)
F: ifn-beta (homo sapiens) (aka interferon beta 1)
G: None of the above. | [E; E] |
<Instruct>: Given the context 'Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.
Transforming growth factor-beta TGF-beta is the prototype for a family of extracellular proteins that affect cell proliferation and tissue differentiation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tgf-beta; transforming growth factor-beta]
<Options>: A: tgf-beta2 (homo sapiens) (aka transforming growth factor beta 2)
B: transforming growth factor beta 1 (xenopus tropicalis) (aka transforming growth factor beta 1)
C: transforming growth factor beta receptor 3 (homo sapiens) (aka transforming growth factor beta receptor 3)
D: tgf-beta3 (homo sapiens) (aka transforming growth factor beta 3)
E: ifn-beta (homo sapiens) (aka interferon beta 1)
F: transforming growth factor beta 3 (homo sapiens) (aka transforming growth factor beta 3)
G: tgfb1 (homo sapiens) (aka transforming growth factor beta 1)
H: None of the above. | [G; G] |
<Instruct>: Given the context 'TGF-beta-related factors, including BMP-2/4, Dpp and activin, act through two types of serine/threonine kinase receptors which can form a heteromeric complex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dpp]
<Options>: A: dpp (drosophila melanogaster) (dipeptidyl aminopeptidase iii (drosophila melanogaster)) (aka dipeptidyl aminopeptidase iii)
B: dppi (homo sapiens) (aka cathepsin c)
C: dpp7 (homo sapiens) (aka dipeptidyl peptidase 7)
D: dpp3 (homo sapiens) (aka dipeptidyl peptidase 3)
E: None of the above. | [E] |
<Instruct>: Given the context 'In Drosophila, Mad is required for signalling by Dpp.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dpp]
<Options>: A: dpp (drosophila melanogaster) (dipeptidyl aminopeptidase iii (drosophila melanogaster)) (aka dipeptidyl aminopeptidase iii)
B: dpp3 (homo sapiens) (aka dipeptidyl peptidase 3)
C: dpp (homo sapiens) (dipeptidyl peptidase 7 (homo sapiens)) (aka dipeptidyl peptidase 7)
D: dppi (homo sapiens) (aka cathepsin c)
E: None of the above. | [E] |
<Instruct>: Given the context 'We have isolated complementary DNAs for four human Mad homologues, one of which, hMAD-4, is identical to DPC-4, a candidate tumour suppressor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmad-4; dpc-4]
<Options>: A: ahd-4 (mus musculus) (aka aldehyde dehydrogenase family 3, subfamily a1)
B: dpc4 (xenopus laevis) (smad family member 4 s homeolog (xenopus laevis)) (aka smad family member 4 s homeolog)
C: smad family member 4 (homo sapiens) (aka smad family member 4)
D: cadm4 (homo sapiens) (aka cell adhesion molecule 4)
E: defective pharyngeal development protein 4 (caenorhabditis elegans) (aka defective pharyngeal development protein 4)
F: protein madd-4 (caenorhabditis elegans) (aka protein madd-4)
G: mad4 (homo sapiens) (aka max dimerization protein 4)
H: amd4 (homo sapiens) (aka protein kinase cgmp-dependent 2)
I: dsc-4 (caenorhabditis elegans) (aka microsomal triglyceride transfer protein homolog)
J: None of the above. | [C; C] |
<Instruct>: Given the context 'We have isolated complementary DNAs for four human Mad homologues, one of which, hMAD-4, is identical to DPC-4, a candidate tumour suppressor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmad-4; dpc-4]
<Options>: A: cell death protein 4 (caenorhabditis elegans) (aka cell death protein 4)
B: odad4 (homo sapiens) (aka outer dynein arm docking complex subunit 4)
C: dsc-4 (caenorhabditis elegans) (aka microsomal triglyceride transfer protein homolog)
D: amd4 (homo sapiens) (aka protein kinase cgmp-dependent 2)
E: hda-4 (caenorhabditis elegans) (aka histone deacetylase 4)
F: dpc4 (xenopus laevis) (smad family member 4 s homeolog (xenopus laevis)) (aka smad family member 4 s homeolog)
G: madh4 (homo sapiens) (aka smad family member 4)
H: mam domain containing 4 (homo sapiens) (aka mam domain containing 4)
I: cadm4 (homo sapiens) (aka cell adhesion molecule 4)
J: None of the above. | [G; G] |
<Instruct>: Given the context 'We have isolated complementary DNAs for four human Mad homologues, one of which, hMAD-4, is identical to DPC-4, a candidate tumour suppressor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmad-4; dpc-4]
<Options>: A: dpc4 (xenopus laevis) (smad family member 4 s homeolog (xenopus laevis)) (aka smad family member 4 s homeolog)
B: cadm4 (homo sapiens) (aka cell adhesion molecule 4)
C: hda-4 (caenorhabditis elegans) (aka histone deacetylase 4)
D: dsc-4 (caenorhabditis elegans) (aka microsomal triglyceride transfer protein homolog)
E: amd4 (homo sapiens) (aka protein kinase cgmp-dependent 2)
F: cell death protein 4 (caenorhabditis elegans) (aka cell death protein 4)
G: odad4 (homo sapiens) (aka outer dynein arm docking complex subunit 4)
H: mam domain containing 4 (homo sapiens) (aka mam domain containing 4)
I: None of the above. | [I; I] |
<Instruct>: Given the context 'hMAD-3 and -4 synergized to induce strong ligand-independent TGF-beta-like responses.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tgf-beta]
<Options>: A: ifn-beta (homo sapiens) (aka interferon beta 1)
B: tgf-beta3 (homo sapiens) (aka transforming growth factor beta 3)
C: transforming growth factor beta 2 (homo sapiens) (aka transforming growth factor beta 2)
D: tgfb (homo sapiens) (aka transforming growth factor beta 1)
E: None of the above. | [D] |
<Instruct>: Given the context 'When truncated at their carboxy termini, hMAD-3 and -4 act as dominant-negative inhibitors of the normal TGF-beta response.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tgf-beta]
<Options>: A: tgf-beta3 (homo sapiens) (aka transforming growth factor beta 3)
B: transforming growth factor beta 2 (homo sapiens) (aka transforming growth factor beta 2)
C: tgfb1 (homo sapiens) (aka transforming growth factor beta 1)
D: ifn-beta (homo sapiens) (aka interferon beta 1)
E: None of the above. | [C] |
<Instruct>: Given the context 'The activity of hMAD-3 and -4 was regulated by the TGF-beta receptors, and hMAD-3 but not hMAD-4 was phosphorylated and associated with the ligand-bound receptor complex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tgf-beta; hmad-3; hmad-4]
<Options>: A: hsmad3 (homo sapiens) (aka smad family member 3)
B: hmad-2 (homo sapiens) (aka smad family member 2)
C: amd4 (homo sapiens) (aka protein kinase cgmp-dependent 2)
D: transforming growth factor beta 3 (homo sapiens) (aka transforming growth factor beta 3)
E: tgf-beta2 (homo sapiens) (aka transforming growth factor beta 2)
F: ahd-4 (mus musculus) (aka aldehyde dehydrogenase family 3, subfamily a1)
G: mamdc3 (homo sapiens) (aka mam domain containing glycosylphosphatidylinositol anchor 1)
H: dmhdac3 (drosophila melanogaster) (aka histone deacetylase 3)
I: amd3 (homo sapiens) (aka bone morphogenetic protein receptor type 1b)
J: mamdc4 (homo sapiens) (aka mam domain containing 4)
K: tgfb1 (homo sapiens) (aka transforming growth factor beta 1)
L: ifn-beta (homo sapiens) (aka interferon beta 1)
M: smad family member 4 (homo sapiens) (aka smad family member 4)
N: odad4 (homo sapiens) (aka outer dynein arm docking complex subunit 4)
O: None of the above. | [K; A; M] |
<Instruct>: Given the context 'The activity of hMAD-3 and -4 was regulated by the TGF-beta receptors, and hMAD-3 but not hMAD-4 was phosphorylated and associated with the ligand-bound receptor complex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tgf-beta; hmad-3; hmad-4]
<Options>: A: transforming growth factor beta 2 (homo sapiens) (aka transforming growth factor beta 2)
B: mad4 (homo sapiens) (aka max dimerization protein 4)
C: amd3 (homo sapiens) (aka bone morphogenetic protein receptor type 1b)
D: mam3 (homo sapiens) (aka mastermind like transcriptional coactivator 2)
E: tgfbeta (homo sapiens) (aka transforming growth factor beta 1)
F: cadm4 (homo sapiens) (aka cell adhesion molecule 4)
G: tgf-beta3 (homo sapiens) (aka transforming growth factor beta 3)
H: odad4 (homo sapiens) (aka outer dynein arm docking complex subunit 4)
I: major affective disorder 4 (homo sapiens) (aka major affective disorder 4)
J: hsmad3 (homo sapiens) (aka smad family member 3)
K: smad family member 4 (homo sapiens) (aka smad family member 4)
L: ifn-beta (homo sapiens) (aka interferon beta 1)
M: mad-3 (homo sapiens) (aka nfkb inhibitor alpha)
N: mamdc3 (homo sapiens) (aka mam domain containing glycosylphosphatidylinositol anchor 1)
O: None of the above. | [E; J; K] |
<Instruct>: Given the context 'The activity of hMAD-3 and -4 was regulated by the TGF-beta receptors, and hMAD-3 but not hMAD-4 was phosphorylated and associated with the ligand-bound receptor complex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tgf-beta; hmad-3; hmad-4]
<Options>: A: mam3 (homo sapiens) (aka mastermind like transcriptional coactivator 2)
B: tgfb1 (homo sapiens) (aka transforming growth factor beta 1)
C: transforming growth factor beta 2 (homo sapiens) (aka transforming growth factor beta 2)
D: ifn-beta (homo sapiens) (aka interferon beta 1)
E: amd4 (homo sapiens) (aka protein kinase cgmp-dependent 2)
F: madh4 (homo sapiens) (aka smad family member 4)
G: dmhdac3 (drosophila melanogaster) (aka histone deacetylase 3)
H: amd3 (homo sapiens) (aka bone morphogenetic protein receptor type 1b)
I: mamdc4 (homo sapiens) (aka mam domain containing 4)
J: hmad-2 (homo sapiens) (aka smad family member 2)
K: cadm4 (homo sapiens) (aka cell adhesion molecule 4)
L: odad4 (homo sapiens) (aka outer dynein arm docking complex subunit 4)
M: hmad-3 (homo sapiens) (aka smad family member 3)
N: tgf-beta3 (homo sapiens) (aka transforming growth factor beta 3)
O: None of the above. | [B; M; F] |
<Instruct>: Given the context 'These results define hMAD-3 and -4 as effectors of the TGF-beta response and demonstrate a function for DPCA-4/hMAD-4 as a tumour suppressor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tgf-beta; dpca-4; hmad-4]
<Options>: A: major affective disorder 4 (homo sapiens) (aka major affective disorder 4)
B: dpc4 (homo sapiens) (aka smad family member 4)
C: d-sas-4 (drosophila melanogaster) (aka spindle assembly abnormal 4)
D: mad4 (homo sapiens) (aka max dimerization protein 4)
E: ifn-beta (homo sapiens) (aka interferon beta 1)
F: transforming growth factor beta 3 (homo sapiens) (aka transforming growth factor beta 3)
G: ciliary dyskinesia, primary, 4 (homo sapiens) (aka ciliary dyskinesia, primary, 4)
H: dpc4 (xenopus tropicalis) (smad family member 4 (xenopus tropicalis)) (aka smad family member 4)
I: spindle assembly abnormal protein 4 (caenorhabditis elegans) (aka spindle assembly abnormal protein 4)
J: mamdc4 (homo sapiens) (aka mam domain containing 4)
K: tgf-beta2 (homo sapiens) (aka transforming growth factor beta 2)
L: transforming growth factor beta 1 (homo sapiens) (aka transforming growth factor beta 1)
M: cadm4 (homo sapiens) (aka cell adhesion molecule 4)
N: None of the above. | [L; B; B] |
<Instruct>: Given the context 'These results define hMAD-3 and -4 as effectors of the TGF-beta response and demonstrate a function for DPCA-4/hMAD-4 as a tumour suppressor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tgf-beta; dpca-4; hmad-4]
<Options>: A: transforming growth factor beta 2 (homo sapiens) (aka transforming growth factor beta 2)
B: cell division cycle associated 4 (xenopus tropicalis) (aka cell division cycle associated 4)
C: transforming growth factor beta 3 (homo sapiens) (aka transforming growth factor beta 3)
D: d-sas-4 (drosophila melanogaster) (aka spindle assembly abnormal 4)
E: mam domain containing 4 (homo sapiens) (aka mam domain containing 4)
F: major affective disorder 4 (homo sapiens) (aka major affective disorder 4)
G: dpc4 (xenopus tropicalis) (smad family member 4 (xenopus tropicalis)) (aka smad family member 4)
H: spindle assembly abnormal protein 4 (caenorhabditis elegans) (aka spindle assembly abnormal protein 4)
I: amd4 (homo sapiens) (aka protein kinase cgmp-dependent 2)
J: tgfbeta (homo sapiens) (aka transforming growth factor beta 1)
K: odad4 (homo sapiens) (aka outer dynein arm docking complex subunit 4)
L: dpc4 (homo sapiens) (aka smad family member 4)
M: ifn-beta (homo sapiens) (aka interferon beta 1)
N: None of the above. | [J; L; L] |
<Instruct>: Given the context 'These results define hMAD-3 and -4 as effectors of the TGF-beta response and demonstrate a function for DPCA-4/hMAD-4 as a tumour suppressor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tgf-beta; dpca-4; hmad-4]
<Options>: A: ciliary dyskinesia, primary, 4 (homo sapiens) (aka ciliary dyskinesia, primary, 4)
B: ifn-beta (homo sapiens) (aka interferon beta 1)
C: tgf-beta1 (homo sapiens) (aka transforming growth factor beta 1)
D: dpc4 (homo sapiens) (aka smad family member 4)
E: dsc-4 (caenorhabditis elegans) (aka microsomal triglyceride transfer protein homolog)
F: dpc4 (xenopus tropicalis) (smad family member 4 (xenopus tropicalis)) (aka smad family member 4)
G: ahd-4 (mus musculus) (aka aldehyde dehydrogenase family 3, subfamily a1)
H: cadm4 (homo sapiens) (aka cell adhesion molecule 4)
I: tgf-beta2 (homo sapiens) (aka transforming growth factor beta 2)
J: spindle assembly abnormal protein 4 (caenorhabditis elegans) (aka spindle assembly abnormal protein 4)
K: odad4 (homo sapiens) (aka outer dynein arm docking complex subunit 4)
L: mam domain containing 4 (homo sapiens) (aka mam domain containing 4)
M: transforming growth factor beta 3 (homo sapiens) (aka transforming growth factor beta 3)
N: None of the above. | [C; D; D] |
<Instruct>: Given the context 'These results define hMAD-3 and -4 as effectors of the TGF-beta response and demonstrate a function for DPCA-4/hMAD-4 as a tumour suppressor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tgf-beta; dpca-4; hmad-4]
<Options>: A: odad4 (homo sapiens) (aka outer dynein arm docking complex subunit 4)
B: dpc4 (xenopus tropicalis) (smad family member 4 (xenopus tropicalis)) (aka smad family member 4)
C: transforming growth factor beta 3 (homo sapiens) (aka transforming growth factor beta 3)
D: ahd-4 (mus musculus) (aka aldehyde dehydrogenase family 3, subfamily a1)
E: ciliary dyskinesia, primary, 4 (homo sapiens) (aka ciliary dyskinesia, primary, 4)
F: tgf-beta1 (homo sapiens) (aka transforming growth factor beta 1)
G: spindle assembly abnormal protein 4 (caenorhabditis elegans) (aka spindle assembly abnormal protein 4)
H: ifn-beta (homo sapiens) (aka interferon beta 1)
I: cadm4 (homo sapiens) (aka cell adhesion molecule 4)
J: tgf-beta2 (homo sapiens) (aka transforming growth factor beta 2)
K: dsc-4 (caenorhabditis elegans) (aka microsomal triglyceride transfer protein homolog)
L: mam domain containing 4 (homo sapiens) (aka mam domain containing 4)
M: None of the above. | [F; M; M] |
<Instruct>: Given the context 'The C5a chemoattractant receptor mediates mucosal defence to infection.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c5a chemoattractant receptor]
<Options>: A: c5ar1 (sus scrofa) (aka complement c5a receptor 1)
B: c5ar1 (homo sapiens) (aka complement c5a receptor 1)
C: c5ar (mus musculus) (aka complement component 5a receptor 1)
D: c5ar2 (homo sapiens) (aka complement c5a receptor 2)
E: c5ar1 (bos taurus) (aka complement c5a receptor 1)
F: None of the above. | [B] |
<Instruct>: Given the context 'A family of G-protein-coupled chemoattractant receptors is known to mediate the transport and activation of neutrophils and macrophages This family includes receptors for chemokines, such as interleukin-8, bacterial formylated peptides, platelet-activating factor, leukotriene B4, and the complement anaphylatoxins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [interleukin-8]
<Options>: A: ccl8 (homo sapiens) (aka c-c motif chemokine ligand 8)
B: fgf-8 (homo sapiens) (aka fibroblast growth factor 8)
C: c-x-c motif chemokine ligand 8 (homo sapiens) (aka c-x-c motif chemokine ligand 8)
D: il18 (homo sapiens) (aka interleukin 18)
E: il1f8 (homo sapiens) (aka interleukin 36 beta)
F: None of the above. | [C] |
<Instruct>: Given the context 'Here we show that mice deficient in the chemoattractant C5a receptor, in comparison to their wild-type littermates, were unable to clear intrapulmonary-instilled Pseudomonas aeruginosa, despite a marked increase in neutrophil influx, and succumbed to pneumonia.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c5a receptor]
<Options>: A: c5ar1 (sus scrofa) (aka complement c5a receptor 1)
B: c5ar (mus musculus) (aka complement component 5a receptor 1)
C: complement c5a receptor 2 (homo sapiens) (aka complement c5a receptor 2)
D: complement c5a receptor 1 (homo sapiens) (aka complement c5a receptor 1)
E: complement c5a receptor 1 (bos taurus) (aka complement c5a receptor 1)
F: None of the above. | [D] |
<Instruct>: Given the context 'These C5a-receptor-deficient mice challenged with sublethal inocula of Pseudomonas become superinfected with secondary bacterial strains.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c5a-receptor]
<Options>: A: c5ar1 (homo sapiens) (aka complement c5a receptor 1)
B: complement c5a receptor 1 (bos taurus) (aka complement c5a receptor 1)
C: c5ar1 (sus scrofa) (aka complement c5a receptor 1)
D: complement c5a receptor 2 (homo sapiens) (aka complement c5a receptor 2)
E: c5ar (mus musculus) (aka complement component 5a receptor 1)
F: None of the above. | [A] |
<Instruct>: Given the context 'We conclude that the C5a receptor has a non-redundant function, and is required for mucosal host defence in the lung.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c5a receptor]
<Options>: A: complement c5a receptor 2 (homo sapiens) (aka complement c5a receptor 2)
B: c5ar1 (bos taurus) (aka complement c5a receptor 1)
C: c5r1 (homo sapiens) (aka complement c5a receptor 1)
D: c5ar (mus musculus) (aka complement component 5a receptor 1)
E: c5ar1 (sus scrofa) (aka complement c5a receptor 1)
F: None of the above. | [C] |
<Instruct>: Given the context 'Cell-cell adhesion mediated by binding of membrane-anchored ligand LERK-2 to the EPH-related receptor human embryonal kinase 2 promotes tyrosine kinase activity.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lerk-2; eph-related receptor human embryonal kinase 2]
<Options>: A: lerk-4 (homo sapiens) (aka ephrin a4)
B: lerk-6 (homo sapiens) (aka ephrin a2)
C: lerk7 (homo sapiens) (aka ephrin a5)
D: erk (homo sapiens) (eph receptor b2 (homo sapiens)) (aka eph receptor b2)
E: ek2 (homo sapiens) (aka eph receptor b3)
F: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
G: epht2 (homo sapiens) (aka eph receptor b1)
H: lerk2 (homo sapiens) (aka ephrin b1)
I: lerk-2 (xenopus laevis) (aka ephrin-b1 l homeolog)
J: eph receptor a2 (homo sapiens) (aka eph receptor a2)
K: None of the above. | [H; E] |
<Instruct>: Given the context 'Cell-cell adhesion mediated by binding of membrane-anchored ligand LERK-2 to the EPH-related receptor human embryonal kinase 2 promotes tyrosine kinase activity.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lerk-2; eph-related receptor human embryonal kinase 2]
<Options>: A: epht2 (homo sapiens) (aka eph receptor b1)
B: lerk2 (homo sapiens) (aka ephrin b1)
C: lerk4 (homo sapiens) (aka ephrin a4)
D: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
E: ephrin-b2 (homo sapiens) (aka ephrin b2)
F: ek2 (homo sapiens) (aka eph receptor b3)
G: ephb2 (homo sapiens) (aka eph receptor b2)
H: ehk-2 (homo sapiens) (aka eph receptor a6)
I: lerk-2 (xenopus laevis) (aka ephrin-b1 l homeolog)
J: lerk1 (homo sapiens) (aka ephrin a1)
K: None of the above. | [B; F] |
<Instruct>: Given the context 'Human embryonal kinase 2 (HEK2) is a protein-tyrosine kinase that is a member of the EPH family of receptors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [embryonal kinase 2; hek2]
<Options>: A: etnk2 (homo sapiens) (aka ethanolamine kinase 2)
B: epht2 (homo sapiens) (aka eph receptor b1)
C: ehk-2 (homo sapiens) (aka eph receptor a6)
D: eph receptor b2 (homo sapiens) (aka eph receptor b2)
E: erb-b2 receptor tyrosine kinase 2 (gallus gallus) (aka erb-b2 receptor tyrosine kinase 2)
F: ethanolamine kinase 2 (gallus gallus) (aka ethanolamine kinase 2)
G: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
H: hek2 (homo sapiens) (aka eph receptor b3)
I: None of the above. | [H; H] |
<Instruct>: Given the context 'Human embryonal kinase 2 (HEK2) is a protein-tyrosine kinase that is a member of the EPH family of receptors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [embryonal kinase 2; hek2]
<Options>: A: etk2 (homo sapiens) (aka eph receptor b3)
B: hek7 (homo sapiens) (aka eph receptor a5)
C: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
D: eph receptor b2 (homo sapiens) (aka eph receptor b2)
E: etk-2 (mus musculus) (aka tyro3 protein tyrosine kinase 3)
F: ehk-2 (homo sapiens) (aka eph receptor a6)
G: etnk2 (homo sapiens) (aka ethanolamine kinase 2)
H: ethanolamine kinase 2 (gallus gallus) (aka ethanolamine kinase 2)
I: None of the above. | [A; A] |
<Instruct>: Given the context 'Transcripts for HEK2 have a wide tissue distribution.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hek2]
<Options>: A: hek (homo sapiens) (aka eph receptor a3)
B: hek3 (homo sapiens) (aka eph receptor a8)
C: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
D: epht2 (homo sapiens) (aka eph receptor b1)
E: hek2 (homo sapiens) (aka eph receptor b3)
F: None of the above. | [E] |
<Instruct>: Given the context 'In order to analyze functional effects between the LERKs and the HEK2 receptor, we expressed HEK2 cDNA in an interleukin-3-dependent progenitor cell line 32D that grows as single cells in culture.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hek2; interleukin-3]
<Options>: A: il-3 (homo sapiens) (aka interleukin 3)
B: hek (homo sapiens) (aka eph receptor a3)
C: interleukin 7 (homo sapiens) (aka interleukin 7)
D: il-2 (homo sapiens) (aka interleukin 2)
E: hek3 (homo sapiens) (aka eph receptor a8)
F: interleukin 5 (homo sapiens) (aka interleukin 5)
G: ephb2 (homo sapiens) (aka eph receptor b2)
H: csf3 (homo sapiens) (aka colony stimulating factor 3)
I: ek2 (homo sapiens) (aka eph receptor b3)
J: epht2 (homo sapiens) (aka eph receptor b1)
K: None of the above. | [I; A] |
<Instruct>: Given the context 'In order to analyze functional effects between the LERKs and the HEK2 receptor, we expressed HEK2 cDNA in an interleukin-3-dependent progenitor cell line 32D that grows as single cells in culture.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hek2; interleukin-3]
<Options>: A: hek2 (homo sapiens) (aka eph receptor b3)
B: eph receptor b2 (homo sapiens) (aka eph receptor b2)
C: epht2 (homo sapiens) (aka eph receptor b1)
D: interleukin 5 (homo sapiens) (aka interleukin 5)
E: hek7 (homo sapiens) (aka eph receptor a5)
F: interleukin 7 (homo sapiens) (aka interleukin 7)
G: interleukin 2 (homo sapiens) (aka interleukin 2)
H: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
I: colony stimulating factor 3 (homo sapiens) (aka colony stimulating factor 3)
J: il-3 (homo sapiens) (aka interleukin 3)
K: None of the above. | [A; J] |
<Instruct>: Given the context 'Within the group of LERKs, LERK-2 and -5 were shown to bind to HEK2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hek2]
<Options>: A: hek (homo sapiens) (aka eph receptor a3)
B: hek2 (homo sapiens) (aka eph receptor b3)
C: epht2 (homo sapiens) (aka eph receptor b1)
D: ehk-2 (homo sapiens) (aka eph receptor a6)
E: hek7 (homo sapiens) (aka eph receptor a5)
F: None of the above. | [B] |
<Instruct>: Given the context 'Membrane-bound and soluble forms of LERK-2 were demonstrated to signal through HEK2 as judged by receptor phosphorylation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lerk-2; hek2]
<Options>: A: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
B: hek2 (homo sapiens) (aka eph receptor b3)
C: lerk-1 (homo sapiens) (aka ephrin a1)
D: lerk2 (homo sapiens) (aka ephrin b1)
E: hek3 (homo sapiens) (aka eph receptor a8)
F: epht2 (homo sapiens) (aka eph receptor b1)
G: lerk-2 (xenopus laevis) (aka ephrin-b1 l homeolog)
H: hek7 (homo sapiens) (aka eph receptor a5)
I: lerk-6 (homo sapiens) (aka ephrin a2)
J: ephrin-b2 (homo sapiens) (aka ephrin b2)
K: None of the above. | [D; B] |
<Instruct>: Given the context 'Membrane-bound and soluble forms of LERK-2 were demonstrated to signal through HEK2 as judged by receptor phosphorylation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lerk-2; hek2]
<Options>: A: lerk7 (homo sapiens) (aka ephrin a5)
B: hek3 (homo sapiens) (aka eph receptor a8)
C: eph receptor b2 (homo sapiens) (aka eph receptor b2)
D: lerk-6 (homo sapiens) (aka ephrin a2)
E: hek2 (homo sapiens) (aka eph receptor b3)
F: lerk-1 (homo sapiens) (aka ephrin a1)
G: hek (homo sapiens) (aka eph receptor a3)
H: lerk-4 (homo sapiens) (aka ephrin a4)
I: epht2 (homo sapiens) (aka eph receptor b1)
J: lerk2 (homo sapiens) (aka ephrin b1)
K: None of the above. | [J; E] |
<Instruct>: Given the context 'Coincubation of HEK2 and LERK-2 expressing cells induced cell-cell adhesion and formation of cell aggregates.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hek2; lerk-2]
<Options>: A: lerk-2 (xenopus laevis) (aka ephrin-b1 l homeolog)
B: hek2 (homo sapiens) (aka eph receptor b3)
C: lerk2 (homo sapiens) (aka ephrin b1)
D: lerk-6 (homo sapiens) (aka ephrin a2)
E: hek3 (homo sapiens) (aka eph receptor a8)
F: lerk7 (homo sapiens) (aka ephrin a5)
G: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
H: eph receptor b2 (homo sapiens) (aka eph receptor b2)
I: hek (homo sapiens) (aka eph receptor a3)
J: lerk-4 (homo sapiens) (aka ephrin a4)
K: None of the above. | [B; C] |
<Instruct>: Given the context 'Coincubation of HEK2 and LERK-2 expressing cells induced cell-cell adhesion and formation of cell aggregates.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hek2; lerk-2]
<Options>: A: lerk7 (homo sapiens) (aka ephrin a5)
B: ehk-2 (homo sapiens) (aka eph receptor a6)
C: lerk2 (homo sapiens) (aka ephrin b1)
D: epht2 (homo sapiens) (aka eph receptor b1)
E: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
F: hek2 (homo sapiens) (aka eph receptor b3)
G: hek7 (homo sapiens) (aka eph receptor a5)
H: lerk-2 (xenopus laevis) (aka ephrin-b1 l homeolog)
I: lerk5 (homo sapiens) (aka ephrin b2)
J: lerk-1 (homo sapiens) (aka ephrin a1)
K: None of the above. | [F; C] |
<Instruct>: Given the context 'This interaction could be inhibited by preincubation of HEK2 expressing cells with soluble LERK-2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hek2; lerk-2]
<Options>: A: lerk4 (homo sapiens) (aka ephrin a4)
B: hek (homo sapiens) (aka eph receptor a3)
C: ephrin-b2 (homo sapiens) (aka ephrin b2)
D: epht2 (homo sapiens) (aka eph receptor b1)
E: lerk-6 (homo sapiens) (aka ephrin a2)
F: hek7 (homo sapiens) (aka eph receptor a5)
G: ek2 (homo sapiens) (aka eph receptor b3)
H: lerk-1 (homo sapiens) (aka ephrin a1)
I: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
J: lerk2 (homo sapiens) (aka ephrin b1)
K: None of the above. | [G; J] |
<Instruct>: Given the context 'This interaction could be inhibited by preincubation of HEK2 expressing cells with soluble LERK-2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hek2; lerk-2]
<Options>: A: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
B: lerk2 (homo sapiens) (aka ephrin b1)
C: lerk4 (homo sapiens) (aka ephrin a4)
D: lerk-6 (homo sapiens) (aka ephrin a2)
E: lerk-2 (xenopus laevis) (aka ephrin-b1 l homeolog)
F: lerk5 (homo sapiens) (aka ephrin b2)
G: epht2 (homo sapiens) (aka eph receptor b1)
H: ek2 (homo sapiens) (aka eph receptor b3)
I: ehk-2 (homo sapiens) (aka eph receptor a6)
J: hek (homo sapiens) (aka eph receptor a3)
K: None of the above. | [H; B] |
<Instruct>: Given the context 'Coexpression of HEK2 and LERK-2 in 32D cells showed reduced kinase activity and autophosphorylation of HEK2 compared with the juxtacrine stimulation, which seems to be due to a reduced sensitivity of the receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hek2; lerk-2]
<Options>: A: hek3 (homo sapiens) (aka eph receptor a8)
B: hek (homo sapiens) (aka eph receptor a3)
C: lerk2 (homo sapiens) (aka ephrin b1)
D: epht2 (homo sapiens) (aka eph receptor b1)
E: lerk-2 (xenopus laevis) (aka ephrin-b1 l homeolog)
F: lerk-6 (homo sapiens) (aka ephrin a2)
G: hek7 (homo sapiens) (aka eph receptor a5)
H: ek2 (homo sapiens) (aka eph receptor b3)
I: ephrin-b2 (homo sapiens) (aka ephrin b2)
J: lerk-4 (homo sapiens) (aka ephrin a4)
K: None of the above. | [H; C] |
<Instruct>: Given the context 'Coexpression of HEK2 and LERK-2 in 32D cells showed reduced kinase activity and autophosphorylation of HEK2 compared with the juxtacrine stimulation, which seems to be due to a reduced sensitivity of the receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hek2; lerk-2]
<Options>: A: hek (homo sapiens) (aka eph receptor a3)
B: lerk5 (homo sapiens) (aka ephrin b2)
C: lerk-6 (homo sapiens) (aka ephrin a2)
D: lerk7 (homo sapiens) (aka ephrin a5)
E: hek3 (homo sapiens) (aka eph receptor a8)
F: lerk1 (homo sapiens) (aka ephrin a1)
G: ehk-2 (homo sapiens) (aka eph receptor a6)
H: epht2 (homo sapiens) (aka eph receptor b1)
I: hek2 (homo sapiens) (aka eph receptor b3)
J: lerk2 (homo sapiens) (aka ephrin b1)
K: None of the above. | [I; J] |
<Instruct>: Given the context 'Expression of the receptor protein tyrosine kinase myk-1/htk in normal and malignant mammary epithelium.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [myk-1; htk]
<Options>: A: mitogen-activated protein kinase kinase 1 (mus musculus) (aka mitogen-activated protein kinase kinase 1)
B: htpk1 (homo sapiens) (aka thiamin pyrophosphokinase 1)
C: mitogen-activated protein kinase kinase kinase 1 (mus musculus) (aka mitogen-activated protein kinase kinase kinase 1)
D: ttk (homo sapiens) (aka ttk protein kinase)
E: myk1 (mus musculus) (aka eph receptor b4)
F: myk1 (homo sapiens) (aka eph receptor b4)
G: atk (homo sapiens) (aka bruton tyrosine kinase)
H: ctk (homo sapiens) (aka megakaryocyte-associated tyrosine kinase)
I: prkmk1 (homo sapiens) (aka mitogen-activated protein kinase kinase 1)
J: None of the above. | [F; F] |
<Instruct>: Given the context 'Expression of the receptor protein tyrosine kinase myk-1/htk in normal and malignant mammary epithelium.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [myk-1; htk]
<Options>: A: mymk (homo sapiens) (aka myomaker, myoblast fusion factor)
B: ptk (homo sapiens) (aka protein tyrosine kinase 2 beta)
C: bmk-1 (mus musculus) (aka mitogen-activated protein kinase 7)
D: htk-l (homo sapiens) (aka ephrin b2)
E: myk1 (homo sapiens) (aka eph receptor b4)
F: ttk (homo sapiens) (aka ttk protein kinase)
G: mitogen-activated protein kinase kinase 1 (mus musculus) (aka mitogen-activated protein kinase kinase 1)
H: prkmk1 (homo sapiens) (aka mitogen-activated protein kinase kinase 1)
I: ctk (homo sapiens) (aka megakaryocyte-associated tyrosine kinase)
J: None of the above. | [E; E] |
<Instruct>: Given the context 'We have recently reported the molecular characterization of a novel murine receptor PTK (myk-1), belonging to the eph-related family, whose expression was differentially regulated during mammary gland development and elevated in invasive mouse mammary tumours.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [myk-1]
<Options>: A: mbk1 (homo sapiens) (aka potassium voltage-gated channel subfamily a member 1)
B: mitogen-activated protein kinase kinase kinase kinase 1 (homo sapiens) (aka mitogen-activated protein kinase kinase kinase kinase 1)
C: mitogen-activated protein kinase kinase kinase 1 (mus musculus) (aka mitogen-activated protein kinase kinase kinase 1)
D: bmk-1 (mus musculus) (aka mitogen-activated protein kinase 7)
E: myk1 (homo sapiens) (aka eph receptor b4)
F: None of the above. | [E] |
<Instruct>: Given the context 'We have recently reported the molecular characterization of a novel murine receptor PTK (myk-1), belonging to the eph-related family, whose expression was differentially regulated during mammary gland development and elevated in invasive mouse mammary tumours.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [myk-1]
<Options>: A: mitogen-activated protein kinase kinase kinase kinase 1 (homo sapiens) (aka mitogen-activated protein kinase kinase kinase kinase 1)
B: mitogen-activated protein kinase kinase kinase 1 (mus musculus) (aka mitogen-activated protein kinase kinase kinase 1)
C: mbk1 (homo sapiens) (aka potassium voltage-gated channel subfamily a member 1)
D: bmk-1 (mus musculus) (aka mitogen-activated protein kinase 7)
E: None of the above. | [E] |
<Instruct>: Given the context 'In this communication we have investigated the cellular origin of myk-1 expression by in situ hybridisation and RNase protection.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [myk-1]
<Options>: A: prkmk1 (homo sapiens) (aka mitogen-activated protein kinase kinase 1)
B: myk1 (mus musculus) (aka eph receptor b4)
C: mitogen-activated protein kinase kinase 1 (mus musculus) (aka mitogen-activated protein kinase kinase 1)
D: myk1 (homo sapiens) (aka eph receptor b4)
E: bmk-1 (mus musculus) (aka mitogen-activated protein kinase 7)
F: None of the above. | [D] |
<Instruct>: Given the context 'Murine antisense myk-1 probe specifically recognised ductal and alveolar epithelium in the resting mouse mammary gland.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [myk-1]
<Options>: A: bmk-1 (mus musculus) (aka mitogen-activated protein kinase 7)
B: mitogen-activated protein kinase kinase kinase kinase 1 (homo sapiens) (aka mitogen-activated protein kinase kinase kinase kinase 1)
C: myk1 (mus musculus) (aka eph receptor b4)
D: mitogen-activated protein kinase kinase 1 (mus musculus) (aka mitogen-activated protein kinase kinase 1)
E: myk1 (homo sapiens) (aka eph receptor b4)
F: None of the above. | [E] |
<Instruct>: Given the context 'In normal human breast, the expression of htk, the human homologue, was also confined to the secretory luminal epithelial cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [htk]
<Options>: A: htk (homo sapiens) (aka eph receptor b4)
B: tpk1 (homo sapiens) (aka thiamin pyrophosphokinase 1)
C: ctk (homo sapiens) (aka megakaryocyte-associated tyrosine kinase)
D: atk (homo sapiens) (aka bruton tyrosine kinase)
E: ptk (homo sapiens) (aka protein tyrosine kinase 2 beta)
F: None of the above. | [A] |
<Instruct>: Given the context 'Elevated expression of htk was found in several human breast carcinoma cell lines as well as in primary, high grade, infiltrating, ductal carcinomas of the breast.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [htk]
<Options>: A: tpk1 (homo sapiens) (aka thiamin pyrophosphokinase 1)
B: ttk protein kinase (homo sapiens) (aka ttk protein kinase)
C: htk (homo sapiens) (aka eph receptor b4)
D: ptk (homo sapiens) (aka protein tyrosine kinase 2 beta)
E: htk-l (homo sapiens) (aka ephrin b2)
F: None of the above. | [C] |
<Instruct>: Given the context 'The specific epithelial expression of the myk-1/htk receptor PTK suggest a specialised role of this eph-related PTK in the differentiation and/or maintenance of secretory epithelium in the adult.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [myk-1; htk]
<Options>: A: mitogen-activated protein kinase kinase 1 (mus musculus) (aka mitogen-activated protein kinase kinase 1)
B: tpk1 (homo sapiens) (aka thiamin pyrophosphokinase 1)
C: myk1 (homo sapiens) (aka eph receptor b4)
D: ttk (homo sapiens) (aka ttk protein kinase)
E: myk1 (mus musculus) (aka eph receptor b4)
F: ptk (homo sapiens) (aka protein tyrosine kinase 2 beta)
G: htk-l (homo sapiens) (aka ephrin b2)
H: prkmk1 (homo sapiens) (aka mitogen-activated protein kinase kinase 1)
I: mbk1 (homo sapiens) (aka potassium voltage-gated channel subfamily a member 1)
J: None of the above. | [C; C] |
<Instruct>: Given the context 'The specific epithelial expression of the myk-1/htk receptor PTK suggest a specialised role of this eph-related PTK in the differentiation and/or maintenance of secretory epithelium in the adult.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [myk-1; htk]
<Options>: A: mitogen-activated protein kinase kinase kinase 1 (mus musculus) (aka mitogen-activated protein kinase kinase kinase 1)
B: ctk (homo sapiens) (aka megakaryocyte-associated tyrosine kinase)
C: htpk1 (homo sapiens) (aka thiamin pyrophosphokinase 1)
D: bmk-1 (mus musculus) (aka mitogen-activated protein kinase 7)
E: mitogen-activated protein kinase kinase kinase kinase 1 (homo sapiens) (aka mitogen-activated protein kinase kinase kinase kinase 1)
F: ptk (homo sapiens) (aka protein tyrosine kinase 2 beta)
G: mitogen-activated protein kinase kinase kinase kinase 1 (mus musculus) (aka mitogen-activated protein kinase kinase kinase kinase 1)
H: myk1 (homo sapiens) (aka eph receptor b4)
I: atk (homo sapiens) (aka bruton tyrosine kinase)
J: None of the above. | [H; H] |
<Instruct>: Given the context 'Cloning and characterization of a novel human clathrin heavy chain gene (CLTCL).
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cltcl]
<Options>: A: chloride channel clic-like 1 (xenopus tropicalis) (aka chloride channel clic-like 1)
B: cltcl (homo sapiens) (aka clathrin heavy chain like 1)
C: chloride channel clic like 1 (bos taurus) (aka chloride channel clic like 1)
D: chloride channel clic like 1 (homo sapiens) (aka chloride channel clic like 1)
E: cltc.l (xenopus laevis) (aka clathrin, heavy chain (hc) l homeolog)
F: None of the above. | [B] |
<Instruct>: Given the context 'An exon representing a novel clathrin heavy chain gene (CLTCL) was isolated during gene identification studies and transcription mapping of human chromosome 22.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cltcl]
<Options>: A: chloride channel clic like 1 (homo sapiens) (aka chloride channel clic like 1)
B: chloride channel clic like 1 (bos taurus) (aka chloride channel clic like 1)
C: cltcl (homo sapiens) (aka clathrin heavy chain like 1)
D: cltcl1.l (xenopus laevis) (aka clathrin heavy chain like 1 l homeolog)
E: cltcl1 (oryctolagus cuniculus) (aka clathrin heavy chain like 1)
F: None of the above. | [C] |
<Instruct>: Given the context 'An exon representing a novel clathrin heavy chain gene (CLTCL) was isolated during gene identification studies and transcription mapping of human chromosome 22.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cltcl]
<Options>: A: chloride channel clic like 1 (homo sapiens) (aka chloride channel clic like 1)
B: cltcl1 (oryctolagus cuniculus) (aka clathrin heavy chain like 1)
C: cltcl1.l (xenopus laevis) (aka clathrin heavy chain like 1 l homeolog)
D: chloride channel clic like 1 (bos taurus) (aka chloride channel clic like 1)
E: None of the above. | [E] |
<Instruct>: Given the context 'The location of CLTCL on human chromosome 22 near the region commonly deleted in DiGeorge and other apparent haploinsufficiency syndromes warrants further investigation into its relationship with these developmental disorders.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cltcl]
<Options>: A: chloride channel clic like 1 (homo sapiens) (aka chloride channel clic like 1)
B: cltcl1 (homo sapiens) (aka clathrin heavy chain like 1)
C: cltcl1 (oryctolagus cuniculus) (aka clathrin heavy chain like 1)
D: cltc.l (xenopus laevis) (aka clathrin, heavy chain (hc) l homeolog)
E: chloride channel clic like 1 (sus scrofa) (aka chloride channel clic like 1)
F: None of the above. | [B] |
<Instruct>: Given the context 'Here, we report the isolation of two Na+/Pi cotransporter cDNAs (RNaPi-1a and RNaPi-1b) from a rat liver cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rnapi-1a; rnapi-1b]
<Options>: A: rpb11b1 (homo sapiens) (aka rna polymerase ii subunit j2)
B: rna polymerase i subunit h (homo sapiens) (aka rna polymerase i subunit h)
C: protein phosphatase 1 regulatory inhibitor subunit 1a (homo sapiens) (aka protein phosphatase 1 regulatory inhibitor subunit 1a)
D: rna polymerase ii subunit i (homo sapiens) (aka rna polymerase ii subunit i)
E: rii-beta (homo sapiens) (aka protein kinase camp-dependent type ii regulatory subunit beta)
F: rpb10beta (homo sapiens) (aka rna polymerase ii, i and iii subunit l)
G: rna polymerase i subunit e (homo sapiens) (aka rna polymerase i subunit e)
H: rna polymerase i subunit a (homo sapiens) (aka rna polymerase i subunit a)
I: rpb11a (homo sapiens) (aka rna polymerase ii subunit j)
J: None of the above. | [J; J] |
<Instruct>: Given the context 'Here, we report the isolation of two Na+/Pi cotransporter cDNAs (RNaPi-1a and RNaPi-1b) from a rat liver cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rnapi-1a; rnapi-1b]
<Options>: A: polr2i (homo sapiens) (aka rna polymerase ii subunit i)
B: rna polymerase i subunit a (homo sapiens) (aka rna polymerase i subunit a)
C: rna polymerase i subunit h (homo sapiens) (aka rna polymerase i subunit h)
D: rna polymerase i subunit b (homo sapiens) (aka rna polymerase i subunit b)
E: rpb10beta (homo sapiens) (aka rna polymerase ii, i and iii subunit l)
F: rna polymerase ii subunit b (homo sapiens) (aka rna polymerase ii subunit b)
G: rpi1p (saccharomyces cerevisiae s288c) (aka rpi1p)
H: protein phosphatase 1 regulatory inhibitor subunit 1b (homo sapiens) (aka protein phosphatase 1 regulatory inhibitor subunit 1b)
I: protein phosphatase 1 regulatory inhibitor subunit 1a (homo sapiens) (aka protein phosphatase 1 regulatory inhibitor subunit 1a)
J: rna polymerase ii subunit i (homo sapiens) (aka rna polymerase ii subunit i)
K: None of the above. | [K; K] |
<Instruct>: Given the context 'The rat cDNAs encode a polypeptide of 465 amino acids, having 62% and 66% identity with the rabbit NaPi-1 and human kidney Na+/Pi cotransporter, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [napi-1; na+/pi cotransporter]
<Options>: A: npat (rattus norvegicus) (aka nuclear protein, co-activator of histone transcription)
B: napi-1 (homo sapiens) (aka solute carrier family 17 member 1)
C: na/pi-cotransporter (drosophila melanogaster) (aka na[+]-dependent inorganic phosphate cotransporter)
D: napi-1 (rattus norvegicus) (aka solute carrier family 17 member 1)
E: c-nap1 (homo sapiens) (aka centrosomal protein 250)
F: npt1 (homo sapiens) (aka solute carrier family 17 member 1)
G: napi-1 (mus musculus) (aka solute carrier family 17 (sodium phosphate), member 1)
H: nap-1 (homo sapiens) (aka c-x-c motif chemokine ligand 8)
I: solute carrier family 1 member 2 (homo sapiens) (aka solute carrier family 1 member 2)
J: vglut1 (homo sapiens) (aka solute carrier family 17 member 7)
K: None of the above. | [K; F] |
<Instruct>: Given the context 'The rat cDNAs encode a polypeptide of 465 amino acids, having 62% and 66% identity with the rabbit NaPi-1 and human kidney Na+/Pi cotransporter, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [napi-1; na+/pi cotransporter]
<Options>: A: napi-1 (homo sapiens) (aka solute carrier family 17 member 1)
B: nipp-1 (homo sapiens) (aka protein phosphatase 1 regulatory subunit 8)
C: napi-1 (rattus norvegicus) (aka solute carrier family 17 member 1)
D: npat (rattus norvegicus) (aka nuclear protein, co-activator of histone transcription)
E: npi-1 (homo sapiens) (aka karyopherin subunit alpha 1)
F: solute carrier family 1 member 2 (xenopus tropicalis) (aka solute carrier family 1 member 2)
G: solute carrier family 11 member 1 (xenopus tropicalis) (aka solute carrier family 11 member 1)
H: npi-1 (xenopus tropicalis) (aka karyopherin alpha 1)
I: solute carrier family 16 member 1 (xenopus tropicalis) (aka solute carrier family 16 member 1)
J: npt1 (homo sapiens) (aka solute carrier family 17 member 1)
K: None of the above. | [K; J] |
<Instruct>: Given the context 'Northern blot analysis showed that a RNaPi-1a--specific probe detected two major transcripts (2.3 and 1.8 kb), whereas a RNaPi-1b--specific probe hybridized with one transcript (1.8 kb) in rat kidney, liver, and hepatocytes in primary culture.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rnapi-1a; rnapi-1b]
<Options>: A: rna polymerase ii subunit b (homo sapiens) (aka rna polymerase ii subunit b)
B: rna polymerase i subunit a (homo sapiens) (aka rna polymerase i subunit a)
C: rna polymerase i subunit b (homo sapiens) (aka rna polymerase i subunit b)
D: rna polymerase ii subunit i (homo sapiens) (aka rna polymerase ii subunit i)
E: rpb11a (homo sapiens) (aka rna polymerase ii subunit j)
F: rna polymerase i subunit e (homo sapiens) (aka rna polymerase i subunit e)
G: protein phosphatase 1 regulatory inhibitor subunit 1b (homo sapiens) (aka protein phosphatase 1 regulatory inhibitor subunit 1b)
H: rpb10beta (homo sapiens) (aka rna polymerase ii, i and iii subunit l)
I: None of the above. | [I; I] |
<Instruct>: Given the context 'Northern blot analysis showed that a RNaPi-1a--specific probe detected two major transcripts (2.3 and 1.8 kb), whereas a RNaPi-1b--specific probe hybridized with one transcript (1.8 kb) in rat kidney, liver, and hepatocytes in primary culture.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rnapi-1a; rnapi-1b]
<Options>: A: rna polymerase i subunit b (homo sapiens) (aka rna polymerase i subunit b)
B: rpb10beta (homo sapiens) (aka rna polymerase ii, i and iii subunit l)
C: rpb11b1 (homo sapiens) (aka rna polymerase ii subunit j2)
D: protein phosphatase 1 regulatory inhibitor subunit 1a (homo sapiens) (aka protein phosphatase 1 regulatory inhibitor subunit 1a)
E: rna polymerase i subunit e (homo sapiens) (aka rna polymerase i subunit e)
F: rna polymerase i subunit h (homo sapiens) (aka rna polymerase i subunit h)
G: protein phosphatase 1 regulatory inhibitor subunit 1b (homo sapiens) (aka protein phosphatase 1 regulatory inhibitor subunit 1b)
H: rna polymerase i subunit a (homo sapiens) (aka rna polymerase i subunit a)
I: polr1b (homo sapiens) (aka rna polymerase i subunit b)
J: rna polymerase ii subunit i (homo sapiens) (aka rna polymerase ii subunit i)
K: None of the above. | [K; K] |
<Instruct>: Given the context 'Rat liver expressed much higher levels of RNaPi-1a than RNaPi-1b, whereas the converse was true for rat kidney.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rnapi-1a; rnapi-1b]
<Options>: A: rna polymerase ii subunit i (homo sapiens) (aka rna polymerase ii subunit i)
B: rpb10beta (homo sapiens) (aka rna polymerase ii, i and iii subunit l)
C: rna polymerase ii subunit b (homo sapiens) (aka rna polymerase ii subunit b)
D: rii-beta (homo sapiens) (aka protein kinase camp-dependent type ii regulatory subunit beta)
E: rna polymerase i subunit h (homo sapiens) (aka rna polymerase i subunit h)
F: rna polymerase i subunit e (homo sapiens) (aka rna polymerase i subunit e)
G: protein phosphatase 1 regulatory inhibitor subunit 1a (homo sapiens) (aka protein phosphatase 1 regulatory inhibitor subunit 1a)
H: rna polymerase i subunit a (homo sapiens) (aka rna polymerase i subunit a)
I: protein phosphatase 1 regulatory inhibitor subunit 1b (homo sapiens) (aka protein phosphatase 1 regulatory inhibitor subunit 1b)
J: rna polymerase i subunit g (homo sapiens) (aka rna polymerase i subunit g)
K: None of the above. | [K; K] |
<Instruct>: Given the context 'Rat liver expressed much higher levels of RNaPi-1a than RNaPi-1b, whereas the converse was true for rat kidney.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rnapi-1a; rnapi-1b]
<Options>: A: rna polymerase i subunit g (homo sapiens) (aka rna polymerase i subunit g)
B: rii-beta (homo sapiens) (aka protein kinase camp-dependent type ii regulatory subunit beta)
C: rna polymerase i subunit h (homo sapiens) (aka rna polymerase i subunit h)
D: protein phosphatase 1 regulatory inhibitor subunit 1a (homo sapiens) (aka protein phosphatase 1 regulatory inhibitor subunit 1a)
E: rna polymerase ii subunit i (homo sapiens) (aka rna polymerase ii subunit i)
F: rpb10beta (homo sapiens) (aka rna polymerase ii, i and iii subunit l)
G: rna polymerase i subunit a (homo sapiens) (aka rna polymerase i subunit a)
H: rna polymerase ii subunit b (homo sapiens) (aka rna polymerase ii subunit b)
I: rpb11b1 (homo sapiens) (aka rna polymerase ii subunit j2)
J: polr2i (homo sapiens) (aka rna polymerase ii subunit i)
K: None of the above. | [K; K] |
<Instruct>: Given the context 'These findings indicate that there are at least two isoforms of RNaPi-1 transcripts expressed in liver and kidney and that the levels of expression of the RNaPi-1a and RNaPi-1b may be controlled by tissue-specific factors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rnapi-1a; rnapi-1b]
<Options>: A: protein phosphatase 1 regulatory inhibitor subunit 1b (homo sapiens) (aka protein phosphatase 1 regulatory inhibitor subunit 1b)
B: polr1b (homo sapiens) (aka rna polymerase i subunit b)
C: rna polymerase ii subunit i (homo sapiens) (aka rna polymerase ii subunit i)
D: polr2i (homo sapiens) (aka rna polymerase ii subunit i)
E: rii-beta (homo sapiens) (aka protein kinase camp-dependent type ii regulatory subunit beta)
F: rna polymerase i subunit e (homo sapiens) (aka rna polymerase i subunit e)
G: rna polymerase i subunit h (homo sapiens) (aka rna polymerase i subunit h)
H: rna polymerase ii subunit b (homo sapiens) (aka rna polymerase ii subunit b)
I: rpi1 (saccharomyces cerevisiae s288c) (aka rpi1p)
J: protein phosphatase 1 regulatory inhibitor subunit 1a (homo sapiens) (aka protein phosphatase 1 regulatory inhibitor subunit 1a)
K: None of the above. | [K; K] |
<Instruct>: Given the context 'These findings indicate that there are at least two isoforms of RNaPi-1 transcripts expressed in liver and kidney and that the levels of expression of the RNaPi-1a and RNaPi-1b may be controlled by tissue-specific factors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rnapi-1a; rnapi-1b]
<Options>: A: rna polymerase i subunit b (homo sapiens) (aka rna polymerase i subunit b)
B: rna polymerase i subunit a (homo sapiens) (aka rna polymerase i subunit a)
C: rpi1p (saccharomyces cerevisiae s288c) (aka rpi1p)
D: protein phosphatase 1 regulatory inhibitor subunit 1b (homo sapiens) (aka protein phosphatase 1 regulatory inhibitor subunit 1b)
E: rna polymerase i subunit e (homo sapiens) (aka rna polymerase i subunit e)
F: rpb11a (homo sapiens) (aka rna polymerase ii subunit j)
G: protein phosphatase 1 regulatory inhibitor subunit 1a (homo sapiens) (aka protein phosphatase 1 regulatory inhibitor subunit 1a)
H: rna polymerase ii subunit b (homo sapiens) (aka rna polymerase ii subunit b)
I: rna polymerase ii subunit i (homo sapiens) (aka rna polymerase ii subunit i)
J: rii-beta (homo sapiens) (aka protein kinase camp-dependent type ii regulatory subunit beta)
K: None of the above. | [K; K] |
<Instruct>: Given the context 'Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells.
p50csk is a tyrosine protein kinase (TPK) that represses the activity of Src family TPKs.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p50csk; pep]
<Options>: A: pep6 (saccharomyces cerevisiae s288c) (aka corvet complex subunit vps3)
B: cask (homo sapiens) (aka calcium/calmodulin dependent serine protein kinase)
C: pep4 (saccharomyces cerevisiae s288c) (aka proteinase a)
D: prkcsh (homo sapiens) (aka prkcsh beta subunit of glucosidase ii)
E: p50csk (mus musculus) (aka c-src tyrosine kinase)
F: pep5 (saccharomyces cerevisiae s288c) (aka tethering complex subunit pep5)
G: pep.5 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 22)
H: csk (homo sapiens) (aka c-terminal src kinase)
I: pep5 (homo sapiens) (aka vps11 core subunit of corvet and hops complexes)
J: s6kb (homo sapiens) (aka ribosomal protein s6 kinase b2)
K: None of the above. | [H; G] |
<Instruct>: Given the context 'Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells.
p50csk is a tyrosine protein kinase (TPK) that represses the activity of Src family TPKs.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p50csk; pep]
<Options>: A: p50csk (mus musculus) (aka c-src tyrosine kinase)
B: pep6 (saccharomyces cerevisiae s288c) (aka corvet complex subunit vps3)
C: pep1 (saccharomyces cerevisiae s288c) (aka type i sorting receptor)
D: pepe (homo sapiens) (aka peptidase e)
E: csk (homo sapiens) (aka c-terminal src kinase)
F: pep.5 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 22)
G: peps (homo sapiens) (aka leucine aminopeptidase 3)
H: prkcsl (homo sapiens) (aka myristoylated alanine rich protein kinase c substrate)
I: s6k (homo sapiens) (aka ribosomal protein s6 kinase b1)
J: s6kb (homo sapiens) (aka ribosomal protein s6 kinase b2)
K: None of the above. | [E; F] |
<Instruct>: Given the context 'We previously showed that Csk is a potent negative regulator of antigen receptor signaling in T lymphocytes and that its Src homology (SH) 3 and SH2 domains are required to inhibit these signals.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [csk]
<Options>: A: serine/threonine protein kinase cbk1 (saccharomyces cerevisiae s288c) (aka serine/threonine protein kinase cbk1)
B: csk (drosophila melanogaster) (costakink (drosophila melanogaster)) (aka costakink)
C: csk (mus musculus) (aka c-src tyrosine kinase)
D: cask (homo sapiens) (aka calcium/calmodulin dependent serine protein kinase)
E: csk (homo sapiens) (aka c-terminal src kinase)
F: None of the above. | [E] |
<Instruct>: Given the context 'To test the idea that the Csk SH3 and SH2 domains mediate interactions with other cellular proteins, we attempted to identify Csk-associated polypeptides using the yeast two-hybrid system.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [csk]
<Options>: A: csk (xenopus laevis) (c-terminal src kinase l homeolog (xenopus laevis)) (aka c-terminal src kinase l homeolog)
B: serine/threonine protein kinase cbk1 (saccharomyces cerevisiae s288c) (aka serine/threonine protein kinase cbk1)
C: cask (homo sapiens) (aka calcium/calmodulin dependent serine protein kinase)
D: sck (homo sapiens) (aka shc adaptor protein 2)
E: csk (homo sapiens) (aka c-terminal src kinase)
F: None of the above. | [E] |
<Instruct>: Given the context 'The results of our experiments demonstrated that Csk physically associates with PEP, a protein tyrosine phosphatase (PTP) expressed in hemopoietic cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [csk; pep]
<Options>: A: csk (homo sapiens) (aka c-terminal src kinase)
B: csk (xenopus laevis) (c-terminal src kinase l homeolog (xenopus laevis)) (aka c-terminal src kinase l homeolog)
C: pep4 (saccharomyces cerevisiae s288c) (aka proteinase a)
D: pep.5 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 22)
E: peps (homo sapiens) (aka leucine aminopeptidase 3)
F: serine/threonine protein kinase cbk1 (saccharomyces cerevisiae s288c) (aka serine/threonine protein kinase cbk1)
G: csk (xenopus laevis) (c-terminal src kinase s homeolog (xenopus laevis)) (aka c-terminal src kinase s homeolog)
H: pep1 (saccharomyces cerevisiae s288c) (aka type i sorting receptor)
I: hck proto-oncogene, src family tyrosine kinase (homo sapiens) (aka hck proto-oncogene, src family tyrosine kinase)
J: pepe (homo sapiens) (aka peptidase e)
K: None of the above. | [A; D] |
<Instruct>: Given the context 'The results of our experiments demonstrated that Csk physically associates with PEP, a protein tyrosine phosphatase (PTP) expressed in hemopoietic cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [csk; pep]
<Options>: A: pepe (homo sapiens) (aka peptidase e)
B: pep1 (saccharomyces cerevisiae s288c) (aka type i sorting receptor)
C: csk (drosophila melanogaster) (costakink (drosophila melanogaster)) (aka costakink)
D: pepa (homo sapiens) (aka carnosine dipeptidase 2)
E: csk (homo sapiens) (aka c-terminal src kinase)
F: hck proto-oncogene, src family tyrosine kinase (homo sapiens) (aka hck proto-oncogene, src family tyrosine kinase)
G: pep6 (saccharomyces cerevisiae s288c) (aka corvet complex subunit vps3)
H: csk (mus musculus) (aka c-src tyrosine kinase)
I: csk (xenopus laevis) (c-terminal src kinase l homeolog (xenopus laevis)) (aka c-terminal src kinase l homeolog)
J: pep.5 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 22)
K: None of the above. | [E; J] |
<Instruct>: Given the context 'Further analyses revealed that this interaction was mediated by the Csk SH3 domain and by a proline-rich region (PPPLPERTP) in the non-catalytic C-terminal portion of PEP.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [csk; pep]
<Options>: A: csk (drosophila melanogaster) (costakink (drosophila melanogaster)) (aka costakink)
B: pepa (homo sapiens) (aka carnosine dipeptidase 2)
C: csk (xenopus laevis) (c-terminal src kinase s homeolog (xenopus laevis)) (aka c-terminal src kinase s homeolog)
D: csk (homo sapiens) (aka c-terminal src kinase)
E: pep4 (saccharomyces cerevisiae s288c) (aka proteinase a)
F: pep.5 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 22)
G: pep1 (saccharomyces cerevisiae s288c) (aka type i sorting receptor)
H: sck (homo sapiens) (aka shc adaptor protein 2)
I: serine/threonine protein kinase cbk1 (saccharomyces cerevisiae s288c) (aka serine/threonine protein kinase cbk1)
J: pepe (homo sapiens) (aka peptidase e)
K: None of the above. | [D; F] |
<Instruct>: Given the context 'Further analyses revealed that this interaction was mediated by the Csk SH3 domain and by a proline-rich region (PPPLPERTP) in the non-catalytic C-terminal portion of PEP.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [csk; pep]
<Options>: A: pep.5 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 22)
B: serine/threonine protein kinase cbk1 (saccharomyces cerevisiae s288c) (aka serine/threonine protein kinase cbk1)
C: csk (xenopus laevis) (c-terminal src kinase l homeolog (xenopus laevis)) (aka c-terminal src kinase l homeolog)
D: csk (homo sapiens) (aka c-terminal src kinase)
E: tethering complex subunit pep5 (saccharomyces cerevisiae s288c) (aka tethering complex subunit pep5)
F: csk (xenopus laevis) (c-terminal src kinase s homeolog (xenopus laevis)) (aka c-terminal src kinase s homeolog)
G: peps (homo sapiens) (aka leucine aminopeptidase 3)
H: cask (homo sapiens) (aka calcium/calmodulin dependent serine protein kinase)
I: pep1 (saccharomyces cerevisiae s288c) (aka type i sorting receptor)
J: pep4 (saccharomyces cerevisiae s288c) (aka proteinase a)
K: None of the above. | [D; A] |
<Instruct>: Given the context 'The association between Csk and PEP was documented in transiently transfected Cos-1 cells and in a variety of cells of hemopoietic lineages, including T cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [csk; pep]
<Options>: A: pep6 (saccharomyces cerevisiae s288c) (aka corvet complex subunit vps3)
B: sck (homo sapiens) (aka shc adaptor protein 2)
C: pepa (homo sapiens) (aka carnosine dipeptidase 2)
D: csk (homo sapiens) (aka c-terminal src kinase)
E: csk (xenopus laevis) (c-terminal src kinase l homeolog (xenopus laevis)) (aka c-terminal src kinase l homeolog)
F: pep5 (homo sapiens) (aka vps11 core subunit of corvet and hops complexes)
G: hck proto-oncogene, src family tyrosine kinase (homo sapiens) (aka hck proto-oncogene, src family tyrosine kinase)
H: pepe (homo sapiens) (aka peptidase e)
I: csk (drosophila melanogaster) (costakink (drosophila melanogaster)) (aka costakink)
J: pep.5 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 22)
K: None of the above. | [D; J] |
<Instruct>: Given the context 'The association between Csk and PEP was documented in transiently transfected Cos-1 cells and in a variety of cells of hemopoietic lineages, including T cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [csk; pep]
<Options>: A: csk (homo sapiens) (aka c-terminal src kinase)
B: hck proto-oncogene, src family tyrosine kinase (homo sapiens) (aka hck proto-oncogene, src family tyrosine kinase)
C: pep1 (saccharomyces cerevisiae s288c) (aka type i sorting receptor)
D: peps (homo sapiens) (aka leucine aminopeptidase 3)
E: csk (xenopus laevis) (c-terminal src kinase l homeolog (xenopus laevis)) (aka c-terminal src kinase l homeolog)
F: sck (homo sapiens) (aka shc adaptor protein 2)
G: csk.s (xenopus laevis) (aka c-terminal src kinase s homeolog)
H: pep6 (saccharomyces cerevisiae s288c) (aka corvet complex subunit vps3)
I: tethering complex subunit pep5 (saccharomyces cerevisiae s288c) (aka tethering complex subunit pep5)
J: pep.5 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 22)
K: None of the above. | [A; J] |
<Instruct>: Given the context 'Additional analyses demonstrated that the association between Csk and PEP is highly specific.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [csk; pep]
<Options>: A: csk (xenopus laevis) (c-terminal src kinase l homeolog (xenopus laevis)) (aka c-terminal src kinase l homeolog)
B: pepe (homo sapiens) (aka peptidase e)
C: pep4 (saccharomyces cerevisiae s288c) (aka proteinase a)
D: csk (drosophila melanogaster) (costakink (drosophila melanogaster)) (aka costakink)
E: csk (mus musculus) (aka c-src tyrosine kinase)
F: pep5 (homo sapiens) (aka vps11 core subunit of corvet and hops complexes)
G: pep1 (saccharomyces cerevisiae s288c) (aka type i sorting receptor)
H: csk (homo sapiens) (aka c-terminal src kinase)
I: pep.5 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 22)
J: csk.s (xenopus laevis) (aka c-terminal src kinase s homeolog)
K: None of the above. | [H; I] |
<Instruct>: Given the context 'Additional analyses demonstrated that the association between Csk and PEP is highly specific.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [csk; pep]
<Options>: A: pepe (homo sapiens) (aka peptidase e)
B: hck proto-oncogene, src family tyrosine kinase (homo sapiens) (aka hck proto-oncogene, src family tyrosine kinase)
C: sck (homo sapiens) (aka shc adaptor protein 2)
D: csk (drosophila melanogaster) (costakink (drosophila melanogaster)) (aka costakink)
E: pep.5 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 22)
F: csk (homo sapiens) (aka c-terminal src kinase)
G: cask (homo sapiens) (aka calcium/calmodulin dependent serine protein kinase)
H: pepa (homo sapiens) (aka carnosine dipeptidase 2)
I: pep5 (homo sapiens) (aka vps11 core subunit of corvet and hops complexes)
J: pep6 (saccharomyces cerevisiae s288c) (aka corvet complex subunit vps3)
K: None of the above. | [F; E] |
<Instruct>: Given the context 'Together, these data indicated that PEP may be an effector and/or a regulator of p50csk in T cells and other hemopoietic cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pep; p50csk]
<Options>: A: pep.5 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 22)
B: pep5 (homo sapiens) (aka vps11 core subunit of corvet and hops complexes)
C: csk (homo sapiens) (aka c-terminal src kinase)
D: s6kb (homo sapiens) (aka ribosomal protein s6 kinase b2)
E: pepa (homo sapiens) (aka carnosine dipeptidase 2)
F: pep4 (saccharomyces cerevisiae s288c) (aka proteinase a)
G: prkcsh (homo sapiens) (aka prkcsh beta subunit of glucosidase ii)
H: sck (homo sapiens) (aka shc adaptor protein 2)
I: cask (homo sapiens) (aka calcium/calmodulin dependent serine protein kinase)
J: pepe (homo sapiens) (aka peptidase e)
K: None of the above. | [A; C] |
<Instruct>: Given the context 'Together, these data indicated that PEP may be an effector and/or a regulator of p50csk in T cells and other hemopoietic cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pep; p50csk]
<Options>: A: pep.5 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 22)
B: pep1 (saccharomyces cerevisiae s288c) (aka type i sorting receptor)
C: cask (homo sapiens) (aka calcium/calmodulin dependent serine protein kinase)
D: pepa (homo sapiens) (aka carnosine dipeptidase 2)
E: p50csk (mus musculus) (aka c-src tyrosine kinase)
F: csk (homo sapiens) (aka c-terminal src kinase)
G: tethering complex subunit pep5 (saccharomyces cerevisiae s288c) (aka tethering complex subunit pep5)
H: s6kb (homo sapiens) (aka ribosomal protein s6 kinase b2)
I: pep4 (saccharomyces cerevisiae s288c) (aka proteinase a)
J: s6k (homo sapiens) (aka ribosomal protein s6 kinase b1)
K: None of the above. | [A; F] |
<Instruct>: Given the context 'Moreover, they allowed the identification of PEP as the first known ligand for the Csk SH3 domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pep; csk]
<Options>: A: csk (mus musculus) (aka c-src tyrosine kinase)
B: pep5 (homo sapiens) (aka vps11 core subunit of corvet and hops complexes)
C: csk (xenopus laevis) (c-terminal src kinase l homeolog (xenopus laevis)) (aka c-terminal src kinase l homeolog)
D: pep4 (saccharomyces cerevisiae s288c) (aka proteinase a)
E: csk (homo sapiens) (aka c-terminal src kinase)
F: hck proto-oncogene, src family tyrosine kinase (homo sapiens) (aka hck proto-oncogene, src family tyrosine kinase)
G: pep5 (saccharomyces cerevisiae s288c) (aka tethering complex subunit pep5)
H: serine/threonine protein kinase cbk1 (saccharomyces cerevisiae s288c) (aka serine/threonine protein kinase cbk1)
I: pep.5 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 22)
J: pep1 (saccharomyces cerevisiae s288c) (aka type i sorting receptor)
K: None of the above. | [I; E] |
<Instruct>: Given the context 'Moreover, they allowed the identification of PEP as the first known ligand for the Csk SH3 domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pep; csk]
<Options>: A: hck proto-oncogene, src family tyrosine kinase (homo sapiens) (aka hck proto-oncogene, src family tyrosine kinase)
B: cask (homo sapiens) (aka calcium/calmodulin dependent serine protein kinase)
C: pep.5 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 22)
D: pep4 (saccharomyces cerevisiae s288c) (aka proteinase a)
E: pep5 (saccharomyces cerevisiae s288c) (aka tethering complex subunit pep5)
F: csk (drosophila melanogaster) (costakink (drosophila melanogaster)) (aka costakink)
G: csk.s (xenopus laevis) (aka c-terminal src kinase s homeolog)
H: csk (homo sapiens) (aka c-terminal src kinase)
I: peps (homo sapiens) (aka leucine aminopeptidase 3)
J: pep1 (saccharomyces cerevisiae s288c) (aka type i sorting receptor)
K: None of the above. | [C; H] |
<Instruct>: Given the context 'cDNA cloning of human allograft inflammatory factor-1: tissue distribution, cytokine induction, and mRNA expression in injured rat carotid arteries.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [allograft inflammatory factor-1]
<Options>: A: il1f1 (homo sapiens) (aka interleukin 1 alpha)
B: allograft inflammatory factor 1 like (homo sapiens) (aka allograft inflammatory factor 1 like)
C: ifnai1 (homo sapiens) (aka interferon induced protein with tetratricopeptide repeats 1)
D: hcinf1 (homo sapiens) (aka cytochrome p450 family 24 subfamily a member 1)
E: allograft inflammatory factor 1 (homo sapiens) (aka allograft inflammatory factor 1)
F: None of the above. | [E] |
<Instruct>: Given the context 'Allograft Inflammatory Factor-1 (AIF-1), a gene previously reported to be expressed in rat IFN gamma-activated macrophages.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [allograft inflammatory factor-1; aif-1; ifn gamma]
<Options>: A: aif (homo sapiens) (aka apoptosis inducing factor mitochondria associated 1)
B: interferon gamma (oryctolagus cuniculus) (aka interferon gamma)
C: ifng (homo sapiens) (aka interferon gamma)
D: aif family member 2 (homo sapiens) (aka aif family member 2)
E: hcinf1 (homo sapiens) (aka cytochrome p450 family 24 subfamily a member 1)
F: irf-1 (homo sapiens) (aka interferon regulatory factor 1)
G: irt1 (homo sapiens) (allograft inflammatory factor 1 (homo sapiens)) (aka allograft inflammatory factor 1)
H: allograft inflammatory factor 1 like (homo sapiens) (aka allograft inflammatory factor 1 like)
I: interferon gamma (gallus gallus) (aka interferon gamma)
J: il1f1 (homo sapiens) (aka interleukin 1 alpha)
K: aifl (homo sapiens) (aka aif family member 3)
L: gmf-gamma (homo sapiens) (aka glia maturation factor gamma)
M: aif-1 (mus musculus) (aka allograft inflammatory factor 1)
N: ifn-gamma (gallus gallus) (aka interferon)
O: None of the above. | [G; G; O] |
<Instruct>: Given the context 'Allograft Inflammatory Factor-1 (AIF-1), a gene previously reported to be expressed in rat IFN gamma-activated macrophages.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [allograft inflammatory factor-1; aif-1; ifn gamma]
<Options>: A: interferon regulatory factor 1 (homo sapiens) (aka interferon regulatory factor 1)
B: allograft inflammatory factor 1 (homo sapiens) (aka allograft inflammatory factor 1)
C: gmf-gamma (homo sapiens) (aka glia maturation factor gamma)
D: il1f1 (homo sapiens) (aka interleukin 1 alpha)
E: ilf-1 (homo sapiens) (aka forkhead box k2)
F: aif family member 3 (homo sapiens) (aka aif family member 3)
G: interferon gamma (gallus gallus) (aka interferon gamma)
H: apaf-1 (homo sapiens) (aka apoptotic peptidase activating factor 1)
I: interferon gamma (homo sapiens) (aka interferon gamma)
J: aif family member 2 (homo sapiens) (aka aif family member 2)
K: aif1l (homo sapiens) (aka allograft inflammatory factor 1 like)
L: ifn-gamma (gallus gallus) (aka interferon)
M: allograft inflammatory factor 1 like (homo sapiens) (aka allograft inflammatory factor 1 like)
N: interferon gamma (sus scrofa) (aka interferon gamma)
O: None of the above. | [B; B; O] |
<Instruct>: Given the context 'Allograft Inflammatory Factor-1 (AIF-1), a gene previously reported to be expressed in rat IFN gamma-activated macrophages.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [allograft inflammatory factor-1; aif-1; ifn gamma]
<Options>: A: aif1l (homo sapiens) (aka allograft inflammatory factor 1 like)
B: ifnai1 (homo sapiens) (aka interferon induced protein with tetratricopeptide repeats 1)
C: interferon gamma (xenopus tropicalis) (aka interferon gamma)
D: aifm1 (homo sapiens) (aka apoptosis inducing factor mitochondria associated 1)
E: ilf-1 (homo sapiens) (aka forkhead box k2)
F: aif family member 2 (homo sapiens) (aka aif family member 2)
G: interferon gamma (oryctolagus cuniculus) (aka interferon gamma)
H: ifng (homo sapiens) (aka interferon gamma)
I: interferon regulatory factor 1 (homo sapiens) (aka interferon regulatory factor 1)
J: aif-1 (mus musculus) (aka allograft inflammatory factor 1)
K: il1f1 (homo sapiens) (aka interleukin 1 alpha)
L: interferon gamma (sus scrofa) (aka interferon gamma)
M: interferon gamma (gallus gallus) (aka interferon gamma)
N: allograft inflammatory factor 1 (homo sapiens) (aka allograft inflammatory factor 1)
O: None of the above. | [N; N; O] |
<Instruct>: Given the context 'This human AIF-1 homologue is inducible in serum and cytokine-stimulated human smooth muscle cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [aif-1]
<Options>: A: aif (homo sapiens) (aka apoptosis inducing factor mitochondria associated 1)
B: aif-1 (homo sapiens) (aka allograft inflammatory factor 1)
C: apaf-1 (homo sapiens) (aka apoptotic peptidase activating factor 1)
D: aif family member 2 (homo sapiens) (aka aif family member 2)
E: aif-1 (mus musculus) (aka allograft inflammatory factor 1)
F: None of the above. | [B] |
<Instruct>: Given the context 'Functional expression of a novel human neurokinin-3 receptor homolog that binds [3H]senktide and [125I-MePhe7]neurokinin B, and is responsive to tachykinin peptide agonists.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [neurokinin-3 receptor; neurokinin b]
<Options>: A: neuromedin b (homo sapiens) (aka neuromedin b)
B: nk2r (homo sapiens) (aka tachykinin receptor 2)
C: tachykinin receptor 3 (rattus norvegicus) (aka tachykinin receptor 3)
D: tachykinin receptor 3 (bos taurus) (aka tachykinin receptor 3)
E: nkb (homo sapiens) (aka tachykinin precursor 3)
F: tachykinin receptor 3 (sus scrofa) (aka tachykinin receptor 3)
G: neuromedin b (rattus norvegicus) (aka neuromedin b)
H: neuropeptide b (homo sapiens) (aka neuropeptide b)
I: neuromedin b (bos taurus) (aka neuromedin b)
J: nk3 (homo sapiens) (tachykinin receptor 3 (homo sapiens)) (aka tachykinin receptor 3)
K: None of the above. | [J; E] |
<Instruct>: Given the context 'Functional expression of a novel human neurokinin-3 receptor homolog that binds [3H]senktide and [125I-MePhe7]neurokinin B, and is responsive to tachykinin peptide agonists.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [neurokinin-3 receptor; neurokinin b]
<Options>: A: tachykinin receptor 3 (bos taurus) (aka tachykinin receptor 3)
B: tachykinin receptor 3 (sus scrofa) (aka tachykinin receptor 3)
C: nkb (homo sapiens) (aka tachykinin precursor 3)
D: tachykinin receptor 2 (homo sapiens) (aka tachykinin receptor 2)
E: nk2r (homo sapiens) (aka tachykinin receptor 2)
F: nk3 (homo sapiens) (tachykinin receptor 3 (homo sapiens)) (aka tachykinin receptor 3)
G: neuromedin b (bos taurus) (aka neuromedin b)
H: neuromedin b (homo sapiens) (aka neuromedin b)
I: nkb1b (homo sapiens) (aka killer cell immunoglobulin like receptor, three ig domains and long cytoplasmic tail 1)
J: tachykinin receptor 3 (rattus norvegicus) (aka tachykinin receptor 3)
K: None of the above. | [F; C] |
<Instruct>: Given the context 'In 1992, Xie et al. identified a cDNA sequence in the expression cloning search for the kappa opioid receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kappa opioid receptor]
<Options>: A: opioid receptor, kappa 1 (rattus norvegicus) (aka opioid receptor, kappa 1)
B: opioid related nociceptin receptor 1 (homo sapiens) (aka opioid related nociceptin receptor 1)
C: opioid receptor, kappa 1 (mus musculus) (aka opioid receptor, kappa 1)
D: oprk (homo sapiens) (aka opioid receptor kappa 1)
E: opioid related nociceptin receptor 1 (rattus norvegicus) (aka opioid related nociceptin receptor 1)
F: None of the above. | [D] |
<Instruct>: Given the context 'This cDNA was highly homologous to the human neurokinin-3 (NK-3) receptor sequence, and displayed lower homology to NK-1 and NK-2 sequences.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [neurokinin-3 (nk-3) receptor; nk-1; nk-2]
<Options>: A: nkr (homo sapiens) (tachykinin receptor 3 (homo sapiens)) (aka tachykinin receptor 3)
B: tachykinin receptor 2 (rattus norvegicus) (aka tachykinin receptor 2)
C: nk-2 (homo sapiens) (aka nk2 homeobox 1)
D: tachykinin receptor 3 (rattus norvegicus) (aka tachykinin receptor 3)
E: nk3r (homo sapiens) (aka tachykinin receptor 3)
F: tachykinin receptor 3 (bos taurus) (aka tachykinin receptor 3)
G: tachykinin receptor 2 (homo sapiens) (aka tachykinin receptor 2)
H: nkr-p1a (homo sapiens) (aka killer cell lectin like receptor b1)
I: nk2r (homo sapiens) (aka tachykinin receptor 2)
J: nkr (rattus norvegicus) (aka tachykinin receptor 3)
K: nkir (homo sapiens) (tachykinin receptor 1 (homo sapiens)) (aka tachykinin receptor 1)
L: nkb (homo sapiens) (aka tachykinin precursor 3)
M: nkna (homo sapiens) (aka tachykinin precursor 1)
N: nk2.3 (homo sapiens) (aka nk2 homeobox 3)
O: tachykinin receptor 3 (xenopus tropicalis) (aka tachykinin receptor 3)
P: None of the above. | [A; K; G] |
<Instruct>: Given the context 'This cDNA was highly homologous to the human neurokinin-3 (NK-3) receptor sequence, and displayed lower homology to NK-1 and NK-2 sequences.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [neurokinin-3 (nk-3) receptor; nk-1; nk-2]
<Options>: A: nkb (homo sapiens) (aka tachykinin precursor 3)
B: nk2r (homo sapiens) (aka tachykinin receptor 2)
C: tachykinin receptor 2 (homo sapiens) (aka tachykinin receptor 2)
D: tachykinin receptor 3 (rattus norvegicus) (aka tachykinin receptor 3)
E: tachykinin receptor 2 (rattus norvegicus) (aka tachykinin receptor 2)
F: nk-2 (homo sapiens) (aka nk2 homeobox 1)
G: nkir (homo sapiens) (tachykinin receptor 1 (homo sapiens)) (aka tachykinin receptor 1)
H: nk2.3 (homo sapiens) (aka nk2 homeobox 3)
I: nkr (rattus norvegicus) (aka tachykinin receptor 3)
J: tachykinin receptor 3 (bos taurus) (aka tachykinin receptor 3)
K: tachykinin receptor 3 (xenopus tropicalis) (aka tachykinin receptor 3)
L: nk3r (homo sapiens) (aka tachykinin receptor 3)
M: nkr-p1a (homo sapiens) (aka killer cell lectin like receptor b1)
N: nkna (homo sapiens) (aka tachykinin precursor 1)
O: None of the above. | [O; G; C] |
<Instruct>: Given the context 'This cDNA was highly homologous to the human neurokinin-3 (NK-3) receptor sequence, and displayed lower homology to NK-1 and NK-2 sequences.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [neurokinin-3 (nk-3) receptor; nk-1; nk-2]
<Options>: A: nk2.3 (homo sapiens) (aka nk2 homeobox 3)
B: nkna (homo sapiens) (aka tachykinin precursor 1)
C: nkr-p1a (homo sapiens) (aka killer cell lectin like receptor b1)
D: tachykinin receptor 2 (homo sapiens) (aka tachykinin receptor 2)
E: nkr (rattus norvegicus) (aka tachykinin receptor 3)
F: tachykinin receptor 3 (rattus norvegicus) (aka tachykinin receptor 3)
G: ntrkr2 (homo sapiens) (aka receptor tyrosine kinase like orphan receptor 2)
H: nk-3r (homo sapiens) (aka tachykinin receptor 3)
I: tachykinin receptor 3 (bos taurus) (aka tachykinin receptor 3)
J: nk3r (homo sapiens) (aka tachykinin receptor 3)
K: nk2 (homo sapiens) (aka tachykinin precursor 1)
L: nk2r (homo sapiens) (aka tachykinin receptor 2)
M: nkir (homo sapiens) (tachykinin receptor 1 (homo sapiens)) (aka tachykinin receptor 1)
N: tachykinin receptor 3 (xenopus tropicalis) (aka tachykinin receptor 3)
O: None of the above. | [H; M; D] |
<Instruct>: Given the context 'This cDNA was highly homologous to the human neurokinin-3 (NK-3) receptor sequence, and displayed lower homology to NK-1 and NK-2 sequences.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [neurokinin-3 (nk-3) receptor; nk-1; nk-2]
<Options>: A: nkr-p1 (homo sapiens) (aka killer cell lectin like receptor b1)
B: tachykinin receptor 3 (rattus norvegicus) (aka tachykinin receptor 3)
C: tachykinin receptor 3 (bos taurus) (aka tachykinin receptor 3)
D: nk3r (homo sapiens) (aka tachykinin receptor 3)
E: tachykinin receptor 3 (xenopus tropicalis) (aka tachykinin receptor 3)
F: nk2 (homo sapiens) (aka tachykinin precursor 1)
G: nk-1 (homo sapiens) (aka beta-1,3-glucuronyltransferase 1)
H: nk2r (homo sapiens) (aka tachykinin receptor 2)
I: nkr (rattus norvegicus) (aka tachykinin receptor 3)
J: tachykinin receptor 2 (homo sapiens) (aka tachykinin receptor 2)
K: tachykinin receptor 3 (homo sapiens) (aka tachykinin receptor 3)
L: tachykinin receptor 1 (homo sapiens) (aka tachykinin receptor 1)
M: ntrkr2 (homo sapiens) (aka receptor tyrosine kinase like orphan receptor 2)
N: nk-2 (homo sapiens) (aka nk2 homeobox 1)
O: None of the above. | [K; L; J] |
<Instruct>: Given the context 'This sequence was stably expressed in Chinese hamster ovary cells, which do not express neurokinin receptors naturally, and ligand binding and second messenger characteristics were compared with a human NK-3 receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nk-3 receptor]
<Options>: A: nk2r (homo sapiens) (aka tachykinin receptor 2)
B: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
C: tac3r (homo sapiens) (aka tachykinin receptor 3)
D: tachykinin receptor 3 (xenopus tropicalis) (aka tachykinin receptor 3)
E: tachykinin receptor 3 (rattus norvegicus) (aka tachykinin receptor 3)
F: None of the above. | [C] |
<Instruct>: Given the context 'The NK-3 receptor homolog bound [3H] senktide with a Kd of 39 nM, similar to that of the NK-3 receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nk-3 receptor]
<Options>: A: nk2r (homo sapiens) (aka tachykinin receptor 2)
B: tachykinin receptor 3 (rattus norvegicus) (aka tachykinin receptor 3)
C: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
D: nk3r (mus musculus) (aka tachykinin receptor 3)
E: tac3r (homo sapiens) (aka tachykinin receptor 3)
F: None of the above. | [E] |
<Instruct>: Given the context 'The rank order of tachykinin peptides competing for [3H]senktide binding at the NK-3 receptor homolog was [MePhe7]neurokinin B > senktide > substance P = neurokinin A > neurokinin B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nk-3 receptor; neurokinin b; substance p; neurokinin a]
<Options>: A: tachykinin precursor 1 (sus scrofa) (aka tachykinin precursor 1)
B: nknb (homo sapiens) (aka tachykinin precursor 3)
C: tachykinin receptor 3 (rattus norvegicus) (aka tachykinin receptor 3)
D: neuromedin b (homo sapiens) (aka neuromedin b)
E: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
F: tachykinin receptor 3 (xenopus tropicalis) (aka tachykinin receptor 3)
G: tachykinin precursor 3 (homo sapiens) (aka tachykinin precursor 3)
H: nkb (sus scrofa) (aka tachykinin precursor 3)
I: neuropeptide b (homo sapiens) (aka neuropeptide b)
J: tachykinin precursor 4 (homo sapiens) (aka tachykinin precursor 4)
K: nkrp1a (homo sapiens) (aka killer cell lectin like receptor b1)
L: tachykinin precursor 1 (homo sapiens) (aka tachykinin precursor 1)
M: tachykinin receptor 2 (homo sapiens) (aka tachykinin receptor 2)
N: nkb (homo sapiens) (aka tachykinin precursor 3)
O: tachykinin receptor 1 (homo sapiens) (aka tachykinin receptor 1)
P: tachykinin, precursor 1 (rattus norvegicus) (aka tachykinin, precursor 1)
Q: tachykinin receptor 3 (homo sapiens) (aka tachykinin receptor 3)
R: nk3r (mus musculus) (aka tachykinin receptor 3)
S: None of the above. | [Q; B; L; L] |
<Instruct>: Given the context 'The rank order of tachykinin peptides competing for [3H]senktide binding at the NK-3 receptor homolog was [MePhe7]neurokinin B > senktide > substance P = neurokinin A > neurokinin B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nk-3 receptor; neurokinin b; substance p; neurokinin a]
<Options>: A: nk3r (mus musculus) (aka tachykinin receptor 3)
B: tachykinin, precursor 1 (rattus norvegicus) (aka tachykinin, precursor 1)
C: nk2r (homo sapiens) (aka tachykinin receptor 2)
D: nknb (homo sapiens) (aka tachykinin precursor 3)
E: neuromedin b (rattus norvegicus) (aka neuromedin b)
F: nkr (homo sapiens) (tachykinin receptor 3 (homo sapiens)) (aka tachykinin receptor 3)
G: neuropeptide b (homo sapiens) (aka neuropeptide b)
H: neuromedin b (homo sapiens) (aka neuromedin b)
I: tachykinin precursor 1 (sus scrofa) (aka tachykinin precursor 1)
J: nk-1 (homo sapiens) (aka beta-1,3-glucuronyltransferase 1)
K: tachykinin precursor 3 (homo sapiens) (aka tachykinin precursor 3)
L: tachykinin precursor 1 (homo sapiens) (aka tachykinin precursor 1)
M: tachykinin receptor 3 (xenopus tropicalis) (aka tachykinin receptor 3)
N: tachykinin precursor 3 (rattus norvegicus) (aka tachykinin precursor 3)
O: nkb (sus scrofa) (aka tachykinin precursor 3)
P: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
Q: None of the above. | [F; D; L; L] |
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