instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'The rank order of tachykinin peptides competing for [3H]senktide binding at the NK-3 receptor homolog was [MePhe7]neurokinin B > senktide > substance P = neurokinin A > neurokinin B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [nk-3 receptor; neurokinin b; substance p; neurokinin a]
<Options>: A: neuromedin b (bos taurus) (aka neuromedin b)
B: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
C: tachykinin precursor 4 (homo sapiens) (aka tachykinin precursor 4)
D: tachykinin receptor 3 (rattus norvegicus) (a... | [H; J; E; E] |
<Instruct>: Given the context 'The rank order of tachykinin peptides competing for [3H]senktide binding at the NK-3 receptor homolog was [MePhe7]neurokinin B > senktide > substance P = neurokinin A > neurokinin B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [nk-3 receptor; neurokinin b; substance p; neurokinin a]
<Options>: A: nkb1b (homo sapiens) (aka killer cell immunoglobulin like receptor, three ig domains and long cytoplasmic tail 1)
B: nkrp1a (homo sapiens) (aka killer cell lectin like receptor b1)
C: tachykinin receptor 3 (xenopus tropicalis) (aka tachy... | [M; Q; L; L] |
<Instruct>: Given the context 'The rank order of tachykinin peptides competing for [3H]senktide binding at the NK-3 receptor homolog was [MePhe7]neurokinin B > senktide > substance P = neurokinin A > neurokinin B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [nk-3 receptor; neurokinin b; substance p; neurokinin a]
<Options>: A: tachykinin receptor 1 (homo sapiens) (aka tachykinin receptor 1)
B: nknb (homo sapiens) (aka tachykinin precursor 3)
C: neuropeptide s (rattus norvegicus) (aka neuropeptide s)
D: tachykinin receptor 3 (rattus norvegicus) (aka tachykinin ... | [Q; B; K; K] |
<Instruct>: Given the context 'The rank order of tachykinin peptides competing for [3H]senktide binding at the NK-3 receptor homolog was [MePhe7]neurokinin B > senktide > substance P = neurokinin A > neurokinin B.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [neurokinin b]
<Options>: A: neuromedin b (bos taurus) (aka neuromedin b)
B: nkb (sus scrofa) (aka tachykinin precursor 3)
C: neuropeptide b (rattus norvegicus) (aka neuropeptide b)
D: tachykinin receptor 2 (homo sapiens) (aka tachykinin receptor 2)
E: nknb (homo sapiens) (aka tachykinin precursor 3)
F: Non... | [E] |
<Instruct>: Given the context 'This cell line also bound [125I-MePhe7]neurokinin B; however, neurokinin B was an effective competitor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [neurokinin b]
<Options>: A: nkb (homo sapiens) (aka tachykinin precursor 3)
B: neuromedin b (rattus norvegicus) (aka neuromedin b)
C: neuromedin b (homo sapiens) (aka neuromedin b)
D: nkb (sus scrofa) (aka tachykinin precursor 3)
E: neuropeptide b (homo sapiens) (aka neuropeptide b)
F: None of the above. | [A] |
<Instruct>: Given the context 'Tachykinin peptides stimulated both inositol phospholipid hydrolysis and arachidonic acid release at NK-3 and NK-3 receptor homolog cell lines, with similar rank orders of potency of [MePhe7] neurokinin B = neurokinin B = senktide > NKA = substance P.', select the correct biomedical conce... | <Mentions>: [nk-3 receptor; neurokinin b; nka]
<Options>: A: tachykinin receptor 2 (homo sapiens) (aka tachykinin receptor 2)
B: nknb (homo sapiens) (aka tachykinin precursor 3)
C: tachykinin receptor 3 (xenopus tropicalis) (aka tachykinin receptor 3)
D: neuromedin b (homo sapiens) (aka neuromedin b)
E: nkr (homo sapie... | [E; B; K] |
<Instruct>: Given the context 'Tachykinin peptides stimulated both inositol phospholipid hydrolysis and arachidonic acid release at NK-3 and NK-3 receptor homolog cell lines, with similar rank orders of potency of [MePhe7] neurokinin B = neurokinin B = senktide > NKA = substance P.', select the correct biomedical conce... | <Mentions>: [nk-3 receptor; neurokinin b; nka]
<Options>: A: nknb (homo sapiens) (aka tachykinin precursor 3)
B: tachykinin receptor 3 (rattus norvegicus) (aka tachykinin receptor 3)
C: nk-3r (homo sapiens) (aka tachykinin receptor 3)
D: nk2r (homo sapiens) (aka tachykinin receptor 2)
E: tachykinin receptor 3 (xenopus ... | [C; A; N] |
<Instruct>: Given the context 'Tachykinin peptides stimulated both inositol phospholipid hydrolysis and arachidonic acid release at NK-3 and NK-3 receptor homolog cell lines, with similar rank orders of potency of [MePhe7] neurokinin B = neurokinin B = senktide > NKA = substance P.', select the correct biomedical conce... | <Mentions>: [nk-3 receptor; neurokinin b; nka]
<Options>: A: nk-1 (homo sapiens) (aka beta-1,3-glucuronyltransferase 1)
B: tac3r (homo sapiens) (aka tachykinin receptor 3)
C: nkb (sus scrofa) (aka tachykinin precursor 3)
D: tachykinin receptor 1 (homo sapiens) (aka tachykinin receptor 1)
E: nk2r (homo sapiens) (aka tac... | [B; H; J] |
<Instruct>: Given the context 'Tachykinin peptides stimulated both inositol phospholipid hydrolysis and arachidonic acid release at NK-3 and NK-3 receptor homolog cell lines, with similar rank orders of potency of [MePhe7] neurokinin B = neurokinin B = senktide > NKA = substance P.', select the correct biomedical conce... | <Mentions>: [substance p]
<Options>: A: tachykinin precursor 3 (homo sapiens) (aka tachykinin precursor 3)
B: nk-1 (homo sapiens) (aka beta-1,3-glucuronyltransferase 1)
C: tachykinin precursor 1 (sus scrofa) (aka tachykinin precursor 1)
D: tachykinin receptor 1 (homo sapiens) (aka tachykinin receptor 1)
E: tachykinin p... | [E] |
<Instruct>: Given the context 'These results indicate that expression of the NK-3 receptor homolog cDNA in the Chinese hamster ovary cell system induces the expression of a receptor site with many similarities but certain key differences from that of the human NK-3 receptor.', select the correct biomedical concept for ... | <Mentions>: [nk-3 receptor]
<Options>: A: tachykinin receptor 3 (xenopus tropicalis) (aka tachykinin receptor 3)
B: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
C: tachykinin receptor 3 (rattus norvegicus) (aka tachykinin receptor 3)
D: nk2r (homo sapiens) (aka tachykinin receptor 2)
E: nkr (... | [E] |
<Instruct>: Given the context 'Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c-type natriuretic peptide]
<Options>: A: natriuretic peptide a (homo sapiens) (aka natriuretic peptide a)
B: c-type natriuretic peptide-like (xenopus tropicalis) (aka c-type natriuretic peptide-like)
C: natriuretic peptide c (rattus norvegicus) (aka natriuretic peptide c)
D: c-type natriuretic peptide 1 (... | [E] |
<Instruct>: Given the context 'Our previous studies on the promoter function of the human C-type natriuretic peptide (CNP) gene revealed the existence of two GC-rich cis elements essential for gene transcription in rat pituitary-derived GH3 cells.', select the correct biomedical concept for each mention using the provi... | <Mentions>: [c-type natriuretic peptide; cnp]
<Options>: A: cnp (homo sapiens) (natriuretic peptide c (homo sapiens)) (aka natriuretic peptide c)
B: cnp-3 (caenorhabditis elegans) (aka calcineurin-interacting protein 3)
C: cnp (xenopus tropicalis) (natriuretic peptide c (xenopus tropicalis)) (aka natriuretic peptide c)... | [A; A] |
<Instruct>: Given the context 'Our previous studies on the promoter function of the human C-type natriuretic peptide (CNP) gene revealed the existence of two GC-rich cis elements essential for gene transcription in rat pituitary-derived GH3 cells.', select the correct biomedical concept for each mention using the provi... | <Mentions>: [c-type natriuretic peptide; cnp]
<Options>: A: cnp (xenopus tropicalis) (2',3'-cyclic nucleotide 3' phosphodiesterase (xenopus tropicalis)) (aka 2',3'-cyclic nucleotide 3' phosphodiesterase)
B: natriuretic peptide c (rattus norvegicus) (aka natriuretic peptide c)
C: natriuretic peptide a (homo sapiens) (ak... | [I; I] |
<Instruct>: Given the context 'Our previous studies on the promoter function of the human C-type natriuretic peptide (CNP) gene revealed the existence of two GC-rich cis elements essential for gene transcription in rat pituitary-derived GH3 cells.', select the correct biomedical concept for each mention using the provi... | <Mentions>: [c-type natriuretic peptide; cnp]
<Options>: A: natriuretic peptide a (homo sapiens) (aka natriuretic peptide a)
B: cnp (xenopus tropicalis) (natriuretic peptide c (xenopus tropicalis)) (aka natriuretic peptide c)
C: natriuretic peptide c (xenopus tropicalis) (aka natriuretic peptide c)
D: cnp (homo sapiens... | [D; D] |
<Instruct>: Given the context 'Several positive clones with specific binding abilities were obtained, and one was identical as TSC-22, a speculated transcriptional modulator stimulated by transforming growth factor beta (TGF-beta) of unknown function.', select the correct biomedical concept for each mention using the p... | <Mentions>: [tsc-22]
<Options>: A: tsc22 domain family member 2 (homo sapiens) (aka tsc22 domain family member 2)
B: tsc22 (homo sapiens) (aka tsc22 domain family member 1)
C: tsc complex subunit 2 (homo sapiens) (aka tsc complex subunit 2)
D: tsc22 domain family member 4 (homo sapiens) (aka tsc22 domain family member ... | [B] |
<Instruct>: Given the context 'TSC-22 significantly enhanced CNP promoter activity in GH3 cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tsc-22; cnp]
<Options>: A: tsc-22 (xenopus tropicalis) (aka tsc22 domain family member 1)
B: tsc24 (homo sapiens) (aka testis expressed 35)
C: tsc22 (homo sapiens) (aka tsc22 domain family member 1)
D: cnp (xenopus tropicalis) (natriuretic peptide c (xenopus tropicalis)) (aka natriuretic peptide c)
E: tsc ... | [C; F] |
<Instruct>: Given the context 'TSC-22 significantly enhanced CNP promoter activity in GH3 cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tsc-22; cnp]
<Options>: A: tsc-22 (mus musculus) (aka tsc22 domain family, member 1)
B: cnp-3 (caenorhabditis elegans) (aka calcineurin-interacting protein 3)
C: tsc22 domain family member 2 (homo sapiens) (aka tsc22 domain family member 2)
D: tsc-22 (drosophila melanogaster) (aka bunched)
E: cnp (xenopus ... | [F; H] |
<Instruct>: Given the context 'We further cloned a 1.8-kb full-length human TSC-22 cDNA from a fetal kidney cDNA library by a combination of polymerase chain reaction and the rapid amplification of the cDNA ends technique.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [tsc-22]
<Options>: A: tsc24 (homo sapiens) (aka testis expressed 35)
B: tsc22 domain family member 4 (homo sapiens) (aka tsc22 domain family member 4)
C: tsc22 (homo sapiens) (aka tsc22 domain family member 1)
D: tsc-22 (drosophila melanogaster) (aka bunched)
E: tsc22 domain family member 2 (homo sapiens) ... | [C] |
<Instruct>: Given the context 'In adults, human TSC-22 mRNA was highly expressed in brain, lung and heart.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tsc-22]
<Options>: A: tsc complex subunit 2 (homo sapiens) (aka tsc complex subunit 2)
B: tsc-22 (mus musculus) (aka tsc22 domain family, member 1)
C: tsc22 (homo sapiens) (aka tsc22 domain family member 1)
D: tsc22 domain family member 2 (homo sapiens) (aka tsc22 domain family member 2)
E: tsc24 (homo sap... | [C] |
<Instruct>: Given the context 'TSC-22 gene expression in GH3 and human aortic endothelial cells was stimulated by cytokines including TGF-beta, in correlation with the CNP mRNA increase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ... | <Mentions>: [tsc-22; cnp]
<Options>: A: tsc-22 (rattus norvegicus) (aka tsc22 domain family, member 1)
B: cnp (homo sapiens) (natriuretic peptide c (homo sapiens)) (aka natriuretic peptide c)
C: cnp (homo sapiens) (2'',3''-cyclic nucleotide 3'' phosphodiesterase (homo sapiens)) (aka 2'',3''-cyclic nucleotide 3'' phosph... | [G; B] |
<Instruct>: Given the context 'TSC-22 gene expression in GH3 and human aortic endothelial cells was stimulated by cytokines including TGF-beta, in correlation with the CNP mRNA increase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ... | <Mentions>: [tsc-22; cnp]
<Options>: A: tsc-22 (drosophila melanogaster) (aka bunched)
B: tsc22 domain family member 4 (homo sapiens) (aka tsc22 domain family member 4)
C: cnp (homo sapiens) (2'',3''-cyclic nucleotide 3'' phosphodiesterase (homo sapiens)) (aka 2'',3''-cyclic nucleotide 3'' phosphodiesterase)
D: tsc-22 ... | [F; G] |
<Instruct>: Given the context 'These results suggest that TSC-22 is a transcriptional regulator of the CNP gene and transmits signals from cytokines, such as TGF-beta, to CNP gene expression.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one... | <Mentions>: [tsc-22; cnp]
<Options>: A: tsc complex subunit 2 (homo sapiens) (aka tsc complex subunit 2)
B: tsc-22 (drosophila melanogaster) (aka bunched)
C: tsc22 (homo sapiens) (aka tsc22 domain family member 1)
D: cnp (xenopus laevis) (natriuretic peptide c l homeolog (xenopus laevis)) (aka natriuretic peptide c l h... | [C; I] |
<Instruct>: Given the context 'These results suggest that TSC-22 is a transcriptional regulator of the CNP gene and transmits signals from cytokines, such as TGF-beta, to CNP gene expression.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one... | <Mentions>: [tsc-22; cnp]
<Options>: A: tsc22 domain family member 4 (homo sapiens) (aka tsc22 domain family member 4)
B: tsc-22 (rattus norvegicus) (aka tsc22 domain family, member 1)
C: tsc-22 (drosophila melanogaster) (aka bunched)
D: cnp (oryctolagus cuniculus) (aka 2',3'-cyclic nucleotide 3' phosphodiesterase)
E: ... | [J; E] |
<Instruct>: Given the context 'Cloning and characterization of Rep-8 (D8S2298E) in the human chromosome 8p11.2-p12.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rep-8; d8s2298e]
<Options>: A: ec_rep1a (homo sapiens) (aka nanos c2hc-type zinc finger 1)
B: d6s231e (homo sapiens) (aka dek proto-oncogene)
C: rep8 (homo sapiens) (aka ubx domain protein 8)
D: rep15 (homo sapiens) (aka rab15 effector protein)
E: rep8 (xenopus laevis) (aka ubx domain protein 8 l homeolog)... | [C; C] |
<Instruct>: Given the context 'Cloning and characterization of Rep-8 (D8S2298E) in the human chromosome 8p11.2-p12.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rep-8; d8s2298e]
<Options>: A: d6s82e (homo sapiens) (aka abhydrolase domain containing 16a, phospholipase)
B: d11ertd498e (mus musculus) (aka wd repeat domain, phosphoinositide interacting 1)
C: d17s978e (homo sapiens) (aka cell division cycle 27)
D: rep-1 (homo sapiens) (aka chm rab escort protein)
E: re... | [G; G] |
<Instruct>: Given the context 'A novel human gene referred to as the Rep-8 gene (D8S2298E) was cloned by a combination of exon trapping, thermal asymmetric interlaced-PCR, and screening of a cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [rep-8; d8s2298e]
<Options>: A: atp-dependent dna helicase rep (escherichia coli str. k-12 substr. mg1655) (aka atp-dependent dna helicase rep)
B: d6s82e (homo sapiens) (aka abhydrolase domain containing 16a, phospholipase)
C: d0h8s2298e (mus musculus) (aka ubx domain protein 8)
D: rep8 (xenopus tropicalis)... | [E; E] |
<Instruct>: Given the context 'A novel human gene referred to as the Rep-8 gene (D8S2298E) was cloned by a combination of exon trapping, thermal asymmetric interlaced-PCR, and screening of a cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [rep-8; d8s2298e]
<Options>: A: d11ertd498e (mus musculus) (aka wd repeat domain, phosphoinositide interacting 1)
B: rep-1 (homo sapiens) (aka chm rab escort protein)
C: s8e (drosophila melanogaster) (aka ribosomal protein s8)
D: d6s82e (homo sapiens) (aka abhydrolase domain containing 16a, phospholipase)
E... | [F; F] |
<Instruct>: Given the context 'The gene consists of eight exons and spans about 20 kb between the glutathione S-reductase and the protein phosphatase 2A beta subunit genes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [glutathione s-reductase]
<Options>: A: glutathione synthetase (sus scrofa) (aka glutathione synthetase)
B: glutathione-disulfide reductase (oryctolagus cuniculus) (aka glutathione-disulfide reductase)
C: glutathione-disulfide reductase (homo sapiens) (aka glutathione-disulfide reductase)
D: gsr (sus scrofa... | [C] |
<Instruct>: Given the context 'The full-length Rep-8 gene contains 1483 nucleotides and codes for a protein of 270 amino acids.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rep-8]
<Options>: A: rep-1 (homo sapiens) (aka chm rab escort protein)
B: ec_rep1a (homo sapiens) (aka nanos c2hc-type zinc finger 1)
C: rep8 (homo sapiens) (aka ubx domain protein 8)
D: atp-dependent dna helicase rep (escherichia coli str. k-12 substr. mg1655) (aka atp-dependent dna helicase rep)
E: rep15... | [C] |
<Instruct>: Given the context 'Southern blot experiments showed that the Rep-8 gene exists as a single copy per haploid.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rep-8]
<Options>: A: rep8 (homo sapiens) (aka ubx domain protein 8)
B: rep-1 (homo sapiens) (aka chm rab escort protein)
C: rep8h (mus musculus) (aka ubx domain protein 8)
D: rep15 (homo sapiens) (aka rab15 effector protein)
E: atp-dependent dna helicase rep (escherichia coli str. k-12 substr. mg1655) (aka... | [A] |
<Instruct>: Given the context 'With a zoo blot analysis, human Rep-8 DNA hybridized strongly with the monkey DNA, but only weakly with the DNAs of species other than Homo sapiens.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each me... | <Mentions>: [rep-8]
<Options>: A: rep8 (xenopus laevis) (aka ubx domain protein 8 l homeolog)
B: rep4 (drosophila melanogaster) (aka dna fragmentation factor-related protein 4)
C: rep-8 (mus musculus) (aka ubx domain protein 8)
D: rep8 (homo sapiens) (aka ubx domain protein 8)
E: rep8 (xenopus tropicalis) (aka ubx doma... | [D] |
<Instruct>: Given the context 'Northern blot analysis showed that it is expressed abundantly in the testis and ovary, suggesting that the Rep-8 gene product may play a role in reproduction.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [rep-8]
<Options>: A: atp-dependent dna helicase rep (escherichia coli str. k-12 substr. mg1655) (aka atp-dependent dna helicase rep)
B: rep8 (xenopus tropicalis) (aka ubx domain protein 8)
C: rep8 (xenopus laevis) (aka ubx domain protein 8 l homeolog)
D: rep8 (homo sapiens) (aka ubx domain protein 8)
E: re... | [D] |
<Instruct>: Given the context 'Northern blot analysis showed that it is expressed abundantly in the testis and ovary, suggesting that the Rep-8 gene product may play a role in reproduction.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [rep-8]
<Options>: A: rep4 (drosophila melanogaster) (aka dna fragmentation factor-related protein 4)
B: rep8 (xenopus tropicalis) (aka ubx domain protein 8)
C: rep8 (xenopus laevis) (aka ubx domain protein 8 l homeolog)
D: atp-dependent dna helicase rep (escherichia coli str. k-12 substr. mg1655) (aka atp-... | [E] |
<Instruct>: Given the context 'Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kit; fms]
<Options>: A: kit proto-oncogene, receptor tyrosine kinase (sus scrofa) (aka kit proto-oncogene, receptor tyrosine kinase)
B: c-fms (homo sapiens) (aka colony stimulating factor 1 receptor)
C: kit proto-oncogene, receptor tyrosine kinase (gallus gallus) (aka kit proto-oncogene, receptor tyrosine ... | [H; B] |
<Instruct>: Given the context 'Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kit; fms]
<Options>: A: colony stimulating factor 1 receptor (homo sapiens) (aka colony stimulating factor 1 receptor)
B: flt-1 (homo sapiens) (aka fms related receptor tyrosine kinase 1)
C: kit proto-oncogene receptor tyrosine kinase (mus musculus) (aka kit proto-oncogene receptor tyrosine kinase)
D: cd11... | [J; A] |
<Instruct>: Given the context 'The KIT and FMS tyrosine kinase receptors, which are implicated in the control of cell growth and differentiation, stem through duplications from a common ancestor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options,... | <Mentions>: [kit; fms]
<Options>: A: fms (escherichia coli str. k-12 substr. mg1655) (aka peptide deformylase)
B: kit (homo sapiens) (aka kit proto-oncogene, receptor tyrosine kinase)
C: kitl (homo sapiens) (aka kit ligand)
D: fms (homo sapiens) (aka colony stimulating factor 1 receptor)
E: kit proto-oncogene, receptor... | [B; D] |
<Instruct>: Given the context 'The KIT and FMS tyrosine kinase receptors, which are implicated in the control of cell growth and differentiation, stem through duplications from a common ancestor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options,... | <Mentions>: [kit; fms]
<Options>: A: kit proto-oncogene, receptor tyrosine kinase (gallus gallus) (aka kit proto-oncogene, receptor tyrosine kinase)
B: cd116 (homo sapiens) (aka colony stimulating factor 2 receptor subunit alpha)
C: cd117 (homo sapiens) (aka kit proto-oncogene, receptor tyrosine kinase)
D: fms (escheri... | [C; E] |
<Instruct>: Given the context 'We have conducted a detailed structural analysis of the two loci containing the KIT and FMS genes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kit; fms]
<Options>: A: kit proto-oncogene, receptor tyrosine kinase (sus scrofa) (aka kit proto-oncogene, receptor tyrosine kinase)
B: kit ligand (homo sapiens) (aka kit ligand)
C: fms (escherichia coli str. k-12 substr. mg1655) (aka peptide deformylase)
D: fms (mus musculus) (aka colony stimulating facto... | [G; I] |
<Instruct>: Given the context 'We have conducted a detailed structural analysis of the two loci containing the KIT and FMS genes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kit; fms]
<Options>: A: kit proto-oncogene, receptor tyrosine kinase (gallus gallus) (aka kit proto-oncogene, receptor tyrosine kinase)
B: kit proto-oncogene receptor tyrosine kinase (mus musculus) (aka kit proto-oncogene receptor tyrosine kinase)
C: fms related receptor tyrosine kinase 4 (homo sapiens) (a... | [J; E] |
<Instruct>: Given the context 'We have conducted a detailed structural analysis of the two loci containing the KIT and FMS genes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kit; fms]
<Options>: A: cd116 (homo sapiens) (aka colony stimulating factor 2 receptor subunit alpha)
B: kitl (homo sapiens) (aka kit ligand)
C: kit proto-oncogene, receptor tyrosine kinase (gallus gallus) (aka kit proto-oncogene, receptor tyrosine kinase)
D: fms (mus musculus) (aka colony stimulating fact... | [E; J] |
<Instruct>: Given the context 'The sequence of the approximately 90-kb KIT locus reveals the position and size of the 21 introns and of the 5' regulatory region of the KIT gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [kit]
<Options>: A: kit proto-oncogene receptor tyrosine kinase (mus musculus) (aka kit proto-oncogene receptor tyrosine kinase)
B: kit proto-oncogene, receptor tyrosine kinase (gallus gallus) (aka kit proto-oncogene, receptor tyrosine kinase)
C: kit ligand (homo sapiens) (aka kit ligand)
D: kit proto-oncog... | [E] |
<Instruct>: Given the context 'The introns and the 3'-untranslated parts of KIT and FMS have been analyzed in parallel.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kit; fms]
<Options>: A: fms related receptor tyrosine kinase 4 (homo sapiens) (aka fms related receptor tyrosine kinase 4)
B: kit proto-oncogene, receptor tyrosine kinase (homo sapiens) (aka kit proto-oncogene, receptor tyrosine kinase)
C: kit proto-oncogene, receptor tyrosine kinase (gallus gallus) (aka k... | [B; G] |
<Instruct>: Given the context 'The introns and the 3'-untranslated parts of KIT and FMS have been analyzed in parallel.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kit; fms]
<Options>: A: kitl (homo sapiens) (aka kit ligand)
B: fms (mus musculus) (aka colony stimulating factor 1 receptor)
C: kit proto-oncogene, receptor tyrosine kinase (gallus gallus) (aka kit proto-oncogene, receptor tyrosine kinase)
D: fms related receptor tyrosine kinase 4 (homo sapiens) (aka fms ... | [I; G] |
<Instruct>: Given the context 'These programs led us to identify a novel gene, designated SMF, immediately downstream of FMS, in the opposite orientation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [smf; fms]
<Options>: A: ssf1 (mus musculus) (aka peter pan homolog)
B: smfn (mus musculus) (aka rna exonuclease 2)
C: fms related receptor tyrosine kinase 4 (homo sapiens) (aka fms related receptor tyrosine kinase 4)
D: c-fms (homo sapiens) (aka colony stimulating factor 1 receptor)
E: flt-1 (homo sapiens)... | [K; D] |
<Instruct>: Given the context 'These programs led us to identify a novel gene, designated SMF, immediately downstream of FMS, in the opposite orientation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [smf; fms]
<Options>: A: fms related receptor tyrosine kinase 3 (homo sapiens) (aka fms related receptor tyrosine kinase 3)
B: sm-f (homo sapiens) (aka small nuclear ribonucleoprotein polypeptide f)
C: smfn (mus musculus) (aka rna exonuclease 2)
D: ssf1 (mus musculus) (aka peter pan homolog)
E: colony stimu... | [K; E] |
<Instruct>: Given the context 'We have isolated the full-length human 56 kDa selenium binding protein (hSP56) cDNA clone, which is the human homolog of mouse 56 kDa selenium binding protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one ... | <Mentions>: [56 kda selenium binding protein; hsp56]
<Options>: A: sp56 (xenopus laevis) (selenium binding protein 1 l homeolog (xenopus laevis)) (aka selenium binding protein 1 l homeolog)
B: hsp56 (homo sapiens) (aka fkbp prolyl isomerase 4)
C: selenium binding protein 1 (xenopus tropicalis) (aka selenium binding pro... | [H; H] |
<Instruct>: Given the context 'We have isolated the full-length human 56 kDa selenium binding protein (hSP56) cDNA clone, which is the human homolog of mouse 56 kDa selenium binding protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one ... | <Mentions>: [56 kda selenium binding protein; hsp56]
<Options>: A: selenium binding protein 1 (xenopus tropicalis) (aka selenium binding protein 1)
B: hca56 (homo sapiens) (aka eukaryotic translation initiation factor 2d)
C: ppp1r56 (homo sapiens) (aka caspase 9)
D: hsp56 (homo sapiens) (aka fkbp prolyl isomerase 4)
E:... | [I; I] |
<Instruct>: Given the context 'Using Northern blot hybridization, we found that this 56 kDa selenium binding protein is expressed in mouse heart with an intermediate level between those found in liver/lung/kidney and intestine.', select the correct biomedical concept for each mention using the provided options. Answer ... | <Mentions>: [56 kda selenium binding protein]
<Options>: A: selenium binding protein 1 (bos taurus) (aka selenium binding protein 1)
B: sbp56 (xenopus laevis) (selenium binding protein 1 s homeolog (xenopus laevis)) (aka selenium binding protein 1 s homeolog)
C: selenium binding protein 1 (gallus gallus) (aka selenium ... | [E] |
<Instruct>: Given the context 'We have also successfully expressed hSP56 in Escherichia coli using the expression vector-pAED4.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hsp56]
<Options>: A: sp56 (homo sapiens) (aka selenium binding protein 1)
B: ppp1r56 (homo sapiens) (aka caspase 9)
C: ss56 (homo sapiens) (aka tripartite motif containing 68)
D: spg56 (homo sapiens) (aka cytochrome p450 family 2 subfamily u member 1)
E: hca56 (homo sapiens) (aka eukaryotic translation ini... | [A] |
<Instruct>: Given the context 'The hSP56 gene is located at human chromosome 1q21-22).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hsp56]
<Options>: A: sp56 (homo sapiens) (aka selenium binding protein 1)
B: hca56 (homo sapiens) (aka eukaryotic translation initiation factor 2d)
C: spg56 (homo sapiens) (aka cytochrome p450 family 2 subfamily u member 1)
D: prss56 (homo sapiens) (aka serine protease 56)
E: ppp1r56 (homo sapiens) (aka ca... | [A] |
<Instruct>: Given the context 'We have cloned a novel serine/threonine protein kinase (PK428) which is highly related (65%) within the kinase domain to the myotonic dystrophy protein kinase (DM-PK), as well as the cyclic AMP-dependent protein kinase (33%).', select the correct biomedical concept for each mention using ... | <Mentions>: [pk428; myotonic dystrophy protein kinase; dm-pk]
<Options>: A: drm-pk (drosophila melanogaster) (aka capability)
B: dm1 protein kinase (xenopus tropicalis) (aka dm1 protein kinase)
C: cg32428 (drosophila melanogaster) (aka uncharacterized protein)
D: dmk (drosophila melanogaster) (aka kinesin heavy chain)
... | [F; J; J] |
<Instruct>: Given the context 'We have cloned a novel serine/threonine protein kinase (PK428) which is highly related (65%) within the kinase domain to the myotonic dystrophy protein kinase (DM-PK), as well as the cyclic AMP-dependent protein kinase (33%).', select the correct biomedical concept for each mention using ... | <Mentions>: [pk428; myotonic dystrophy protein kinase; dm-pk]
<Options>: A: dtk (mus musculus) (aka tyro3 protein tyrosine kinase 3)
B: pk428 (homo sapiens) (aka cdc42 binding protein kinase alpha)
C: l(2)k05428 (drosophila melanogaster) (aka dribble)
D: dmk (drosophila melanogaster) (aka kinesin heavy chain)
E: dm1 pr... | [B; L; L] |
<Instruct>: Given the context 'We have cloned a novel serine/threonine protein kinase (PK428) which is highly related (65%) within the kinase domain to the myotonic dystrophy protein kinase (DM-PK), as well as the cyclic AMP-dependent protein kinase (33%).', select the correct biomedical concept for each mention using ... | <Mentions>: [pk428; myotonic dystrophy protein kinase; dm-pk]
<Options>: A: pkm (drosophila melanogaster) (pyruvate kinase (drosophila melanogaster)) (aka pyruvate kinase)
B: dmkp (drosophila melanogaster) (aka map kinase-specific phosphatase)
C: deoxythymidylate kinase (mus musculus) (aka deoxythymidylate kinase)
D: s... | [J; K; K] |
<Instruct>: Given the context 'Northern blots demonstrate that PK428 mRNA is distributed widely among tissues and is expressed at the highest levels in pancreas, heart, and skeletal muscle, with lower levels in liver and lung.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [pk428]
<Options>: A: l(2)k05428 (drosophila melanogaster) (aka dribble)
B: l(2)k04218 (drosophila melanogaster) (aka charlatan)
C: pk428 (homo sapiens) (aka cdc42 binding protein kinase alpha)
D: cg42828 (drosophila melanogaster) (aka uncharacterized protein)
E: l(2)k09828 (drosophila melanogaster) (aka mi... | [C] |
<Instruct>: Given the context 'Two PK428 mRNAs 10 and 3.8 kilobase pairs in size are seen in a number of cell lines, including hematopoietic and breast cancer cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separat... | <Mentions>: [pk428]
<Options>: A: l(2)k05428 (drosophila melanogaster) (aka dribble)
B: pk428 (homo sapiens) (aka cdc42 binding protein kinase alpha)
C: pk428 (rattus norvegicus) (aka cdc42 binding protein kinase alpha)
D: l(2)k09828 (drosophila melanogaster) (aka mitochondrial trifunctional protein beta subunit)
E: cg... | [B] |
<Instruct>: Given the context 'Immunoprecipitation of the transiently expressed PK428 protein and incubation with [gamma-32P]ATP demonstrate that it is capable of autophosphorylation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [pk428]
<Options>: A: cell-pk42 (drosophila melanogaster) (aka maternal effect cellularisation defect c)
B: su(tor)2-408 (drosophila melanogaster) (aka su(tor)2-408)
C: pk428 (homo sapiens) (aka cdc42 binding protein kinase alpha)
D: l(2)k09828 (drosophila melanogaster) (aka mitochondrial trifunctional prot... | [C] |
<Instruct>: Given the context 'Immunoprecipitation of the transiently expressed PK428 protein and incubation with [gamma-32P]ATP demonstrate that it is capable of autophosphorylation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [pk428]
<Options>: A: l(2)k09828 (drosophila melanogaster) (aka mitochondrial trifunctional protein beta subunit)
B: l(2)k05428 (drosophila melanogaster) (aka dribble)
C: cell-pk42 (drosophila melanogaster) (aka maternal effect cellularisation defect c)
D: su(tor)2-408 (drosophila melanogaster) (aka su(tor)... | [E] |
<Instruct>: Given the context 'In addition, immunoprecipitates of the PK428 protein kinase also phosphorylated histone H1 and a peptide encoding a cyclic AMP-dependent protein kinase substrate.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [pk428]
<Options>: A: pk428 (homo sapiens) (aka cdc42 binding protein kinase alpha)
B: cg32428 (drosophila melanogaster) (aka uncharacterized protein)
C: pk428 (rattus norvegicus) (aka cdc42 binding protein kinase alpha)
D: su(tor)2-408 (drosophila melanogaster) (aka su(tor)2-408)
E: l(2)k04218 (drosophila ... | [A] |
<Instruct>: Given the context 'The gene corresponding to the 3.8-kb PK428 mRNA, and its corresponding 65-kDa protein, was isolated by polymerase chain reaction screening of a P1 phage human genomic library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [pk428]
<Options>: A: cg42828 (drosophila melanogaster) (aka uncharacterized protein)
B: l(2)k05428 (drosophila melanogaster) (aka dribble)
C: pk428 (homo sapiens) (aka cdc42 binding protein kinase alpha)
D: cell-pk42 (drosophila melanogaster) (aka maternal effect cellularisation defect c)
E: l(2)k09828 (dr... | [C] |
<Instruct>: Given the context 'Using this P1 phage clone as a probe, the PK428 gene was located on 1q41-42, a possible location for a human senescence gene, a gene associated with Rippling muscle disease, as well as a region associated with genetically acquired mental retardation.', select the correct biomedical concep... | <Mentions>: [pk428; a gene associated with rippling muscle disease]
<Options>: A: rmd1 (homo sapiens) (rippling muscle disease 1 (homo sapiens)) (aka rippling muscle disease 1)
B: arv1 homolog, fatty acid homeostasis modulator (gallus gallus) (aka arv1 homolog, fatty acid homeostasis modulator)
C: cg42828 (drosophila m... | [E; A] |
<Instruct>: Given the context 'Using this P1 phage clone as a probe, the PK428 gene was located on 1q41-42, a possible location for a human senescence gene, a gene associated with Rippling muscle disease, as well as a region associated with genetically acquired mental retardation.', select the correct biomedical concep... | <Mentions>: [pk428; a gene associated with rippling muscle disease]
<Options>: A: ras-related associated with diabetes (mus musculus) (aka ras-related associated with diabetes)
B: su(tor)2-408 (drosophila melanogaster) (aka su(tor)2-408)
C: rippling muscle disease 1 (homo sapiens) (aka rippling muscle disease 1)
D: cel... | [H; C] |
<Instruct>: Given the context 'Isolation and characterization of a structural homologue of human PRK2 from rat liver.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [prk2]
<Options>: A: pak-2 (homo sapiens) (aka protein kinase n2)
B: prka2 (homo sapiens) (aka palm2 and akap2 fusion)
C: pkc2 (homo sapiens) (aka protein kinase c zeta)
D: pk2 (homo sapiens) (aka prokineticin 2)
E: prkm2 (homo sapiens) (aka mitogen-activated protein kinase 1)
F: None of the above. | [A] |
<Instruct>: Given the context 'A homologue of human protein kinase C (PKC)-related kinase-2, PRK2, which had previously escaped identification in normal mammalian tissues, was isolated from rat liver as the protease-activated kinase (PAK) originally named PAK-2.', select the correct biomedical concept for each mention ... | <Mentions>: [protein kinase c (pkc)-related kinase-2; prk2; pak-2]
<Options>: A: serine/threonine-protein kinase prk-2 (caenorhabditis elegans) (aka serine/threonine-protein kinase prk-2)
B: pak2 (xenopus laevis) (protein kinase n2 s homeolog (xenopus laevis)) (aka protein kinase n2 s homeolog)
C: pk2 (homo sapiens) (a... | [J; J; O] |
<Instruct>: Given the context 'A homologue of human protein kinase C (PKC)-related kinase-2, PRK2, which had previously escaped identification in normal mammalian tissues, was isolated from rat liver as the protease-activated kinase (PAK) originally named PAK-2.', select the correct biomedical concept for each mention ... | <Mentions>: [protein kinase c (pkc)-related kinase-2; prk2; pak-2]
<Options>: A: pk2 (homo sapiens) (aka prokineticin 2)
B: pkk2 (homo sapiens) (aka ankyrin repeat and kinase domain containing 1)
C: pak2 (drosophila melanogaster) (p21-activated kinase (drosophila melanogaster)) (aka p21-activated kinase)
D: g protein-c... | [N; N; N] |
<Instruct>: Given the context 'A homologue of human protein kinase C (PKC)-related kinase-2, PRK2, which had previously escaped identification in normal mammalian tissues, was isolated from rat liver as the protease-activated kinase (PAK) originally named PAK-2.', select the correct biomedical concept for each mention ... | <Mentions>: [protein kinase c (pkc)-related kinase-2; prk2; pak-2]
<Options>: A: prk2 (homo sapiens) (aka protein kinase n2)
B: pak2 (homo sapiens) (protein kinase n2 (homo sapiens)) (aka protein kinase n2)
C: protein kinase c;protein kinase c-like 2 (caenorhabditis elegans) (aka protein kinase c;protein kinase c-like ... | [A; A; O] |
<Instruct>: Given the context 'A homologue of human protein kinase C (PKC)-related kinase-2, PRK2, which had previously escaped identification in normal mammalian tissues, was isolated from rat liver as the protease-activated kinase (PAK) originally named PAK-2.', select the correct biomedical concept for each mention ... | <Mentions>: [protein kinase c (pkc)-related kinase-2; prk2; pak-2]
<Options>: A: pk2 (homo sapiens) (aka prokineticin 2)
B: pkn2 (homo sapiens) (aka protein kinase n2)
C: g protein-coupled receptor kinase 2 (homo sapiens) (aka g protein-coupled receptor kinase 2)
D: pak2 (xenopus laevis) (protein kinase n2 s homeolog (... | [B; B; N] |
<Instruct>: Given the context 'The 130-kDa cytosolic enzyme was purified to homogeneity and shown by tryptic peptide and reverse transcriptase- polymerase chain reaction (RT-PCR)-amplified rat cDNA sequence analyses to be structurally related to the 116-kDa rat hepatic PAK-1/protein kinase N (PKN) and, even more closel... | <Mentions>: [pak-1; protein kinase n; pkn; 130-kda human pkc-related kinase]
<Options>: A: p90-rsk2 (homo sapiens) (aka ribosomal protein s6 kinase a3)
B: stk7 (homo sapiens) (protein kinase n2 (homo sapiens)) (aka protein kinase n2)
C: pak-5 (homo sapiens) (aka bub1b-pak6 readthrough)
D: snf related kinase (homo sapie... | [T; T; T; B] |
<Instruct>: Given the context 'The 130-kDa cytosolic enzyme was purified to homogeneity and shown by tryptic peptide and reverse transcriptase- polymerase chain reaction (RT-PCR)-amplified rat cDNA sequence analyses to be structurally related to the 116-kDa rat hepatic PAK-1/protein kinase N (PKN) and, even more closel... | <Mentions>: [pak-1; protein kinase n; pkn; 130-kda human pkc-related kinase]
<Options>: A: snf related kinase (homo sapiens) (aka snf related kinase)
B: npkc-eta (homo sapiens) (aka protein kinase c eta)
C: pak7 (homo sapiens) (aka p21 (rac1) activated kinase 5)
D: beta-pak (homo sapiens) (aka p21 (rac1) activated kina... | [S; S; S; S] |
<Instruct>: Given the context 'The 130-kDa cytosolic enzyme was purified to homogeneity and shown by tryptic peptide and reverse transcriptase- polymerase chain reaction (RT-PCR)-amplified rat cDNA sequence analyses to be structurally related to the 116-kDa rat hepatic PAK-1/protein kinase N (PKN) and, even more closel... | <Mentions>: [pak-1; protein kinase n; pkn; 130-kda human pkc-related kinase]
<Options>: A: pkn (drosophila melanogaster) (protein kinase n (drosophila melanogaster)) (aka protein kinase n)
B: protein kinase n (drosophila melanogaster) (aka protein kinase n)
C: pkn (drosophila melanogaster) (uncharacterized protein (dro... | [T; T; T; Q] |
<Instruct>: Given the context 'The 130-kDa cytosolic enzyme was purified to homogeneity and shown by tryptic peptide and reverse transcriptase- polymerase chain reaction (RT-PCR)-amplified rat cDNA sequence analyses to be structurally related to the 116-kDa rat hepatic PAK-1/protein kinase N (PKN) and, even more closel... | <Mentions>: [pak-1; protein kinase n; pkn; 130-kda human pkc-related kinase]
<Options>: A: pak-1 (homo sapiens) (aka protein kinase n1)
B: cnk (homo sapiens) (polo like kinase 3 (homo sapiens)) (aka polo like kinase 3)
C: p90-rsk3 (homo sapiens) (aka ribosomal protein s6 kinase a2)
D: protein kinase n (drosophila melan... | [U; U; U; E] |
<Instruct>: Given the context 'The 130-kDa cytosolic enzyme was purified to homogeneity and shown by tryptic peptide and reverse transcriptase- polymerase chain reaction (RT-PCR)-amplified rat cDNA sequence analyses to be structurally related to the 116-kDa rat hepatic PAK-1/protein kinase N (PKN) and, even more closel... | <Mentions>: [pak-1; protein kinase n; pkn; 130-kda human pkc-related kinase]
<Options>: A: pkn-alpha (homo sapiens) (aka protein kinase n1)
B: prkn (bos taurus) (aka parkin rbr e3 ubiquitin protein ligase)
C: prkn (homo sapiens) (aka parkin rbr e3 ubiquitin protein ligase)
D: pak-5 (homo sapiens) (aka bub1b-pak6 readth... | [S; S; S; P] |
<Instruct>: Given the context 'The 130-kDa cytosolic enzyme was purified to homogeneity and shown by tryptic peptide and reverse transcriptase- polymerase chain reaction (RT-PCR)-amplified rat cDNA sequence analyses to be structurally related to the 116-kDa rat hepatic PAK-1/protein kinase N (PKN) and, even more closel... | <Mentions>: [prk2]
<Options>: A: prk2 (homo sapiens) (aka protein kinase n2)
B: prkm2 (homo sapiens) (aka mitogen-activated protein kinase 1)
C: prkg2 (homo sapiens) (aka protein kinase cgmp-dependent 2)
D: pkc2 (homo sapiens) (aka protein kinase c zeta)
E: pkk2 (homo sapiens) (aka ankyrin repeat and kinase domain cont... | [A] |
<Instruct>: Given the context 'Rat myeloma RNA was used as the RT-PCR template because of its relative abundance in PAK-2/PRK2 mRNA compared with liver and other rat tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [pak-2; prk2]
<Options>: A: pak2 (xenopus laevis) (protein kinase n2 s homeolog (xenopus laevis)) (aka protein kinase n2 s homeolog)
B: pak2 (drosophila melanogaster) (p21-activated kinase (drosophila melanogaster)) (aka p21-activated kinase)
C: pkc2 (homo sapiens) (aka protein kinase c zeta)
D: p21 (rac1) ... | [J; H] |
<Instruct>: Given the context 'Rat myeloma RNA was used as the RT-PCR template because of its relative abundance in PAK-2/PRK2 mRNA compared with liver and other rat tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [pak-2; prk2]
<Options>: A: pkc2 (homo sapiens) (aka protein kinase c zeta)
B: prkcb2 (homo sapiens) (aka protein kinase c beta)
C: prka2 (homo sapiens) (aka palm2 and akap2 fusion)
D: pak2 (xenopus laevis) (protein kinase n2 s homeolog (xenopus laevis)) (aka protein kinase n2 s homeolog)
E: pkk2 (homo sapi... | [J; F] |
<Instruct>: Given the context 'The catalytic properties of PAK-2/PRK2 in many respects resembled those of hepatic PAK-1/PKN, but were distinguished by more favorable kinetics with several peptide substrates, and greater sensitivity to PKC pseudosubstrate and polybasic amino acid inhibitors.', select the correct biomedi... | <Mentions>: [pak-2; prk2; pak-1; pkn]
<Options>: A: pak2 (xenopus laevis) (protein kinase n2 s homeolog (xenopus laevis)) (aka protein kinase n2 s homeolog)
B: prkm2 (homo sapiens) (aka mitogen-activated protein kinase 1)
C: pak2 (drosophila melanogaster) (p21-activated kinase (drosophila melanogaster)) (aka p21-activa... | [S; D; S; S] |
<Instruct>: Given the context 'The catalytic properties of PAK-2/PRK2 in many respects resembled those of hepatic PAK-1/PKN, but were distinguished by more favorable kinetics with several peptide substrates, and greater sensitivity to PKC pseudosubstrate and polybasic amino acid inhibitors.', select the correct biomedi... | <Mentions>: [pak-2; prk2; pak-1; pkn]
<Options>: A: pkn (mus musculus) (aka protein kinase n1)
B: pak-1 (homo sapiens) (aka protein kinase n1)
C: pkn (homo sapiens) (aka protein kinase n1)
D: pak2 (drosophila melanogaster) (p21-activated kinase (drosophila melanogaster)) (aka p21-activated kinase)
E: prkm2 (homo sapien... | [S; H; S; S] |
<Instruct>: Given the context 'The catalytic properties of PAK-2/PRK2 in many respects resembled those of hepatic PAK-1/PKN, but were distinguished by more favorable kinetics with several peptide substrates, and greater sensitivity to PKC pseudosubstrate and polybasic amino acid inhibitors.', select the correct biomedi... | <Mentions>: [pak-2; prk2; pak-1; pkn]
<Options>: A: prk2 (homo sapiens) (aka protein kinase n2)
B: prkn (homo sapiens) (aka parkin rbr e3 ubiquitin protein ligase)
C: pak2 (drosophila melanogaster) (p21-activated kinase (drosophila melanogaster)) (aka p21-activated kinase)
D: prkg2 (homo sapiens) (aka protein kinase cg... | [S; L; S; S] |
<Instruct>: Given the context 'The catalytic properties of PAK-2/PRK2 in many respects resembled those of hepatic PAK-1/PKN, but were distinguished by more favorable kinetics with several peptide substrates, and greater sensitivity to PKC pseudosubstrate and polybasic amino acid inhibitors.', select the correct biomedi... | <Mentions>: [pak-2; prk2; pak-1; pkn]
<Options>: A: pkn (mus musculus) (aka protein kinase n1)
B: pkn2 (homo sapiens) (aka protein kinase n2)
C: pak2 (xenopus laevis) (protein kinase n2 s homeolog (xenopus laevis)) (aka protein kinase n2 s homeolog)
D: prkcn (homo sapiens) (aka protein kinase d3)
E: pak-6 (homo sapiens... | [S; J; S; S] |
<Instruct>: Given the context 'PAK-2/PRK2 was also activated by lipids, particularly cardiolipin and to a lesser extent by other acidic phospholipids and unsaturated fatty acids.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [pak-2; prk2]
<Options>: A: prkg2 (homo sapiens) (aka protein kinase cgmp-dependent 2)
B: pak-3beta (homo sapiens) (aka p21 (rac1) activated kinase 3)
C: pak2 (homo sapiens) (p21 (rac1) activated kinase 2 (homo sapiens)) (aka p21 (rac1) activated kinase 2)
D: pkn2 (homo sapiens) (aka protein kinase n2)
E: p... | [K; J] |
<Instruct>: Given the context 'PAK-2/PRK2 was also activated by lipids, particularly cardiolipin and to a lesser extent by other acidic phospholipids and unsaturated fatty acids.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [pak-2; prk2]
<Options>: A: pak-3beta (homo sapiens) (aka p21 (rac1) activated kinase 3)
B: pkc2 (homo sapiens) (aka protein kinase c zeta)
C: prkcb2 (homo sapiens) (aka protein kinase c beta)
D: pak2 (xenopus laevis) (protein kinase n2 s homeolog (xenopus laevis)) (aka protein kinase n2 s homeolog)
E: prkm... | [K; J] |
<Instruct>: Given the context 'It was concluded that PAK-2 is the rat homologue of human PRK2, with biochemical properties distinct from although overlapping those of the PAK-1/PKN/PRK1 isoform.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [pak-2; prk2; pak-1; pkn]
<Options>: A: prka2 (homo sapiens) (aka palm2 and akap2 fusion)
B: pak2 (homo sapiens) (p21 (rac1) activated kinase 2 (homo sapiens)) (aka p21 (rac1) activated kinase 2)
C: pkn (mus musculus) (aka protein kinase n1)
D: pkn2 (homo sapiens) (aka protein kinase n2)
E: prkn (bos taurus... | [S; H; S; S] |
<Instruct>: Given the context 'It was concluded that PAK-2 is the rat homologue of human PRK2, with biochemical properties distinct from although overlapping those of the PAK-1/PKN/PRK1 isoform.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [pak-2; prk2; pak-1; pkn]
<Options>: A: prkg2 (homo sapiens) (aka protein kinase cgmp-dependent 2)
B: pak-2 (homo sapiens) (aka protein kinase n2)
C: beta-pak (homo sapiens) (aka p21 (rac1) activated kinase 3)
D: pkc2 (homo sapiens) (aka protein kinase c zeta)
E: pak-1 (homo sapiens) (aka protein kinase n1)... | [S; B; S; S] |
<Instruct>: Given the context 'It was concluded that PAK-2 is the rat homologue of human PRK2, with biochemical properties distinct from although overlapping those of the PAK-1/PKN/PRK1 isoform.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [pak-2; prk2; pak-1; pkn]
<Options>: A: prkcn (homo sapiens) (aka protein kinase d3)
B: p21 (rac1) activated kinase 1 (homo sapiens) (aka p21 (rac1) activated kinase 1)
C: pkn (mus musculus) (aka protein kinase n1)
D: pak-3beta (homo sapiens) (aka p21 (rac1) activated kinase 3)
E: pkn2 (homo sapiens) (aka p... | [S; E; S; S] |
<Instruct>: Given the context 'It was concluded that PAK-2 is the rat homologue of human PRK2, with biochemical properties distinct from although overlapping those of the PAK-1/PKN/PRK1 isoform.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [pak-2; prk2; pak-1; pkn]
<Options>: A: pkk2 (homo sapiens) (aka ankyrin repeat and kinase domain containing 1)
B: pak-5 (homo sapiens) (aka bub1b-pak6 readthrough)
C: pak-3beta (homo sapiens) (aka p21 (rac1) activated kinase 3)
D: prkcn (homo sapiens) (aka protein kinase d3)
E: pkn (drosophila melanogaster... | [T; L; T; T] |
<Instruct>: Given the context 'It was concluded that PAK-2 is the rat homologue of human PRK2, with biochemical properties distinct from although overlapping those of the PAK-1/PKN/PRK1 isoform.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [prk1]
<Options>: A: prk (homo sapiens) (aka polo like kinase 3)
B: prkaa1 (homo sapiens) (aka protein kinase amp-activated catalytic subunit alpha 1)
C: prkn (homo sapiens) (aka parkin rbr e3 ubiquitin protein ligase)
D: prkcl1 (homo sapiens) (aka protein kinase n1)
E: prka1 (homo sapiens) (aka a-kinase an... | [D] |
<Instruct>: Given the context 'Human dipeptidyl-peptidase I. Gene characterization, localization, and expression.
Dipeptidyl-peptidase I, a lysosomal cysteine proteinase, is important in intracellular degradation of proteins and appears to be a central coordinator for activation of many serine proteinases in immune/inf... | <Mentions>: [dipeptidyl-peptidase i]
<Options>: A: dpp-i (homo sapiens) (aka cathepsin c)
B: dipeptidyl peptidase 3 (homo sapiens) (aka dipeptidyl peptidase 3)
C: dipeptidyl peptidase family member 1 (caenorhabditis elegans) (aka dipeptidyl peptidase family member 1)
D: dipeptidyl peptidase 7 (homo sapiens) (aka dipept... | [A] |
<Instruct>: Given the context 'In the present investigation the gene for dipeptidyl-peptidase I was cloned and characterized.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dipeptidyl-peptidase i]
<Options>: A: dipeptidyl peptidase 3 (homo sapiens) (aka dipeptidyl peptidase 3)
B: dpp1 (homo sapiens) (aka cathepsin c)
C: dipeptidase 1 (homo sapiens) (aka dipeptidase 1)
D: dipeptidyl peptidase family member 1 (caenorhabditis elegans) (aka dipeptidyl peptidase family member 1)
E... | [B] |
<Instruct>: Given the context 'Northern analyses demonstrated that the dipeptidyl-peptidase I message is expressed at high levels in lung, kidney, and placenta, at moderate to low levels in many organs, and at barely detectable levels in the brain, suggesting tissue-specific regulation.', select the correct biomedical ... | <Mentions>: [dipeptidyl-peptidase i]
<Options>: A: dipeptidyl peptidase 7 (homo sapiens) (aka dipeptidyl peptidase 7)
B: dpp1 (homo sapiens) (aka cathepsin c)
C: dipeptidase 1 (homo sapiens) (aka dipeptidase 1)
D: tripeptidyl peptidase 1 (homo sapiens) (aka tripeptidyl peptidase 1)
E: dipeptidyl peptidase family member... | [B] |
<Instruct>: Given the context 'Treatment of lymphocytes with interleukin-2 resulted in a significant increase in dipeptidyl-peptidase I mRNA levels, suggesting that this gene is subjected to transcriptional regulation.', select the correct biomedical concept for each mention using the provided options. Answer by listin... | <Mentions>: [interleukin-2; dipeptidyl-peptidase i]
<Options>: A: ii (homo sapiens) (dipeptidyl peptidase 7 (homo sapiens)) (aka dipeptidyl peptidase 7)
B: il22 (homo sapiens) (aka interleukin 22)
C: dipeptidyl peptidase family member 1 (caenorhabditis elegans) (aka dipeptidyl peptidase family member 1)
D: dpp1 (homo s... | [F; D] |
<Instruct>: Given the context 'Treatment of lymphocytes with interleukin-2 resulted in a significant increase in dipeptidyl-peptidase I mRNA levels, suggesting that this gene is subjected to transcriptional regulation.', select the correct biomedical concept for each mention using the provided options. Answer by listin... | <Mentions>: [interleukin-2; dipeptidyl-peptidase i]
<Options>: A: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
B: csf2 (homo sapiens) (aka colony stimulating factor 2)
C: il22 (homo sapiens) (aka interleukin 22)
D: dipeptidase 1 (homo sapiens) (aka dipeptidase 1)
E: tripeptidyl peptidase 1 (homo sapiens) (aka ... | [H; F] |
<Instruct>: Given the context 'The results provide initial insights into the molecular basis for the regulation of human dipeptidyl-peptidase I.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dipeptidyl-peptidase i]
<Options>: A: dpp-i (homo sapiens) (aka cathepsin c)
B: dipeptidyl peptidase family member 1 (caenorhabditis elegans) (aka dipeptidyl peptidase family member 1)
C: dipeptidase 1 (homo sapiens) (aka dipeptidase 1)
D: dipeptidyl peptidase 7 (homo sapiens) (aka dipeptidyl peptidase 7)
... | [A] |
<Instruct>: Given the context 'Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [osteoprotegerin]
<Options>: A: gitrl (homo sapiens) (aka tnf superfamily member 18)
B: tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) (mus musculus) (aka tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin))
C: opg (homo sapiens) (tnf receptor superfamily membe... | [C] |
<Instruct>: Given the context 'The protein, termed Osteoprotegerin (OPG), is a novel member of the TNF receptor superfamily.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [osteoprotegerin; opg]
<Options>: A: opg (homo sapiens) (tnf receptor superfamily member 11b (homo sapiens)) (aka tnf receptor superfamily member 11b)
B: opg (homo sapiens) (basic transcription factor 3 pseudogene 11 (homo sapiens)) (aka basic transcription factor 3 pseudogene 11)
C: trailr-1 (homo sapiens)... | [A; A] |
<Instruct>: Given the context 'The protein, termed Osteoprotegerin (OPG), is a novel member of the TNF receptor superfamily.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [osteoprotegerin; opg]
<Options>: A: gitr (homo sapiens) (aka tnf receptor superfamily member 18)
B: opg (xenopus laevis) (tumor necrosis factor receptor superfamily member 11b l homeolog (xenopus laevis)) (aka tumor necrosis factor receptor superfamily member 11b l homeolog)
C: opg (homo sapiens) (tnf rece... | [C; C] |
<Instruct>: Given the context 'In vivo, hepatic expression of OPG in transgenic mice results in a profound yet nonlethal osteopetrosis, coincident with a decrease in later stages of osteoclast differentiation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the sel... | <Mentions>: [opg]
<Options>: A: opgl (xenopus laevis) (tnf superfamily member 11 l homeolog (xenopus laevis)) (aka tnf superfamily member 11 l homeolog)
B: opg (homo sapiens) (tnf receptor superfamily member 11b (homo sapiens)) (aka tnf receptor superfamily member 11b)
C: opg (rattus norvegicus) (aka tnf receptor super... | [B] |
<Instruct>: Given the context 'These same effects are observed upon administration of recombinant OPG into normal mice.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [opg]
<Options>: A: opg (homo sapiens) (basic transcription factor 3 pseudogene 11 (homo sapiens)) (aka basic transcription factor 3 pseudogene 11)
B: opgg (escherichia coli str. k-12 substr. mg1655) (aka osmoregulated periplasmic glucans biosynthesis protein g)
C: opg (homo sapiens) (tnf receptor superfami... | [C] |
<Instruct>: Given the context 'In vitro, osteoclast differentiation from precursor cells is blocked in a dose-dependent manner by recombinant OPG.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [opg]
<Options>: A: opg (xenopus laevis) (tumor necrosis factor receptor superfamily member 11b l homeolog (xenopus laevis)) (aka tumor necrosis factor receptor superfamily member 11b l homeolog)
B: opg (homo sapiens) (tnf receptor superfamily member 11b (homo sapiens)) (aka tnf receptor superfamily member ... | [B] |
<Instruct>: Given the context 'In vitro, osteoclast differentiation from precursor cells is blocked in a dose-dependent manner by recombinant OPG.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [opg]
<Options>: A: opgg (escherichia coli str. k-12 substr. mg1655) (aka osmoregulated periplasmic glucans biosynthesis protein g)
B: opgl (xenopus laevis) (tnf superfamily member 11 l homeolog (xenopus laevis)) (aka tnf superfamily member 11 l homeolog)
C: opg (homo sapiens) (basic transcription factor 3 ... | [E] |
<Instruct>: Given the context 'Furthermore, OPG blocks ovariectomy-associated bone loss in rats.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [opg]
<Options>: A: opgl (xenopus laevis) (tnf superfamily member 11 l homeolog (xenopus laevis)) (aka tnf superfamily member 11 l homeolog)
B: opg (homo sapiens) (tnf receptor superfamily member 11b (homo sapiens)) (aka tnf receptor superfamily member 11b)
C: rankl (homo sapiens) (aka tnf superfamily membe... | [B] |
<Instruct>: Given the context 'These data show that OPG can act as a soluble factor in the regulation of bone mass and imply a utility for OPG in the treatment of osteoporosis associated with increased osteoclast activity.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [opg]
<Options>: A: opg (homo sapiens) (basic transcription factor 3 pseudogene 11 (homo sapiens)) (aka basic transcription factor 3 pseudogene 11)
B: opgg (escherichia coli str. k-12 substr. mg1655) (aka osmoregulated periplasmic glucans biosynthesis protein g)
C: opgl (rattus norvegicus) (aka tnf superfam... | [D] |
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