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medium_convergence_01094 | TNK2 and RACK1 share common interaction partners. One such shared partner is described by evidence stating: 'We demonstrate ACK binds to all five PI3K regulatory subunit isoforms and directly phosphorylates the alpha, beta, 50kDa alpha, and 55kDa alpha isoforms on Tyr607 (or analogous residues).' Which protein is encod... | Phosphatidylinositol 3-kinase regulatory subunit alpha | Medium | convergence | {"qa_id":"medium_convergence_01094","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TNK2 and RACK1 share common interaction partners. One such shared partner is described by evidence stating: 'We demonstrate ACK binds to all five PI3K regula... | |
medium_convergence_01095 | Both Human alphaherpesvirus 3 and Human immunodeficiency virus 1 are reported to downregulate a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) shows a log2 fold change of approximately -1.105 and an adjusted p-value of 4.346e-06. Which protein is encoded by this gene? | Mitochondrial import inner membrane translocase subunit Tim21 | Medium | convergence | {"qa_id":"medium_convergence_01095","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Human immunodeficiency virus 1 are reported to downregulate a specific gene. Experimental data for this gene in a melanoma ... | |
medium_convergence_01096 | IL17B and IL17RB are both involved in multiple shared biological processes. One such process is supported by evidence stating: 'We demonstrate that in the human immune system, IL-17B is functionally similar to IL-25 and elicits type 2 cytokine secretion from innate type 2 lymphocytes, NKT, and CD4+ CRTH2+ Th2 cells.' W... | interleukin-5 production | Medium | convergence | {"qa_id":"medium_convergence_01096","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IL17B and IL17RB are both involved in multiple shared biological processes. One such process is supported by evidence stating: 'We demonstrate that in the hu... | |
medium_convergence_01097 | Both 'regulation of RNA import into nucleus' and 'regulation of RNA export from nucleus' are subtypes of a shared biological process. Evidence regarding one of the entities involved in this hierarchy describes it as 'Any process that modulates the frequency, rate or extent of movement of RNA from the cytoplasm to the n... | regulation of intracellular transport | Medium | convergence | {"qa_id":"medium_convergence_01097","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both 'regulation of RNA import into nucleus' and 'regulation of RNA export from nucleus' are subtypes of a shared biological process. Evidence regarding one ... | |
medium_convergence_01098 | Vaccinia virus and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) shows a log2 fold change of -1.828 and an adjusted p-value of 0.00954. Which protein is encoded by this gene? | SID1 transmembrane family member 2 | Medium | convergence | {"qa_id":"medium_convergence_01098","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) sh... | |
medium_convergence_01100 | FLT3 and KIT each interact with more than one shared protein. Evidence concerning one of these shared proteins reports: 'Pull-down experiments using GST (glutathione transferase)-fusion proteins of the different domains of c-Kit showed that a specific adapter protein almost exclusively binds to the phosphorylated juxta... | SH2B adapter protein 3 | Medium | convergence | {"qa_id":"medium_convergence_01100","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FLT3 and KIT each interact with more than one shared protein. Evidence concerning one of these shared proteins reports: 'Pull-down experiments using GST (glu... | |
medium_convergence_01101 | Both mesonephric nephron tubule epithelial cells and kidney cortex tubule cells are subtypes of a common parent cell type. Evidence regarding this shared parent entity states: 'Any epithelial cell that is part of some mesonephric nephron tubule.' Which cell type is the direct parent of this shared entity? | kidney epithelial cell | Medium | convergence | {"qa_id":"medium_convergence_01101","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both mesonephric nephron tubule epithelial cells and kidney cortex tubule cells are subtypes of a common parent cell type. Evidence regarding this shared par... | |
medium_convergence_01102 | NEDD8 and CUL5 both interact with a specific shared protein. Evidence indicates that this protein is involved in the formation of a novel E3 ligase through interaction with the CUL5-ELOB/C-RNF7 complex, and that three deleterious variants affect the binding amount of this protein and CUL5. Which cellular component is t... | cytoplasm | Medium | convergence | {"qa_id":"medium_convergence_01102","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NEDD8 and CUL5 both interact with a specific shared protein. Evidence indicates that this protein is involved in the formation of a novel E3 ligase through i... | |
medium_convergence_01103 | CHMP4B and CHMP5 both interact with a specific protein. Experimental evidence involving double and triple immunofluorescence, proximity ligation immunofluorescence, and co-immunoprecipitation in KSHV-infected cells revealed that this protein associates with KSHV-containing macropinosomes. Furthermore, its interaction l... | Tumor susceptibility gene 101 protein | Medium | convergence | {"qa_id":"medium_convergence_01103","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHMP4B and CHMP5 both interact with a specific protein. Experimental evidence involving double and triple immunofluorescence, proximity ligation immunofluore... | |
medium_convergence_01104 | KAT5 and CBX6 share a common interaction partner. Evidence regarding this shared partner states: 'This modification occurred at lysine 758 and catalysed by Tip60.' Which protein is encoded by this shared interaction partner? | Lysine-specific demethylase 2B | Medium | convergence | {"qa_id":"medium_convergence_01104","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KAT5 and CBX6 share a common interaction partner. Evidence regarding this shared partner states: 'This modification occurred at lysine 758 and catalysed by T... | |
medium_convergence_01105 | ESR1 and SMAD2 share common interacting partners. One such shared partner is distinguished by evidence that estrogen induces an interaction between it and ERalpha. Which biological process is this specific shared partner involved in? | positive regulation of transcription by RNA polymerase II | Medium | convergence | {"qa_id":"medium_convergence_01105","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and SMAD2 share common interacting partners. One such shared partner is distinguished by evidence that estrogen induces an interaction between it and ER... | |
medium_convergence_01106 | EPS15 and APOB share a common interaction partner. Evidence indicates that this shared partner is localized to clathrin-coated pits at the plasma membrane and binds to EPS15, which serves as an important adaptor protein in clathrin-mediated endocytosis. Which protein is encoded by this shared interaction partner? | F-BAR domain only protein 2 | Medium | convergence | {"qa_id":"medium_convergence_01106","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EPS15 and APOB share a common interaction partner. Evidence indicates that this shared partner is localized to clathrin-coated pits at the plasma membrane an... | |
medium_convergence_01107 | CENPA and CENPS each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Here, we purified non-nucleosomal CENP-A complexes to identify direct CENP-A partners involved in such a mechanism and identified this protein.' Which protein is encoded by that entity? | Holliday junction recognition protein | Medium | convergence | {"qa_id":"medium_convergence_01107","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPA and CENPS each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Here, we purified non-nucleosoma... | |
medium_convergence_01108 | DVL1 and DVL2 both interact with a specific protein. Evidence indicates that this protein interacts with and co-localizes with Dvl-1 at the lateral membrane of polarized epithelial cells. Which protein is encoded by the gene corresponding to this interacting partner? | Protein naked cuticle homolog 2 | Medium | convergence | {"qa_id":"medium_convergence_01108","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DVL1 and DVL2 both interact with a specific protein. Evidence indicates that this protein interacts with and co-localizes with Dvl-1 at the lateral membrane ... | |
medium_convergence_01109 | Both IKBKB and IKBKG interact with a common protein. Evidence indicates that knocking down TRIM14 disrupts the association between the NF-κB essential modulator (NEMO) and this shared protein, thereby attenuating the antiviral response. Which disease is associated with this protein as a biomarker? | breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_01109","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both IKBKB and IKBKG interact with a common protein. Evidence indicates that knocking down TRIM14 disrupts the association between the NF-κB essential modula... | |
medium_convergence_01110 | ALYREF and CSTF2T share a common binding partner. Evidence indicates that this shared partner interacts with the mRNA export factor Aly and can rescue the loss of Sub2p (the yeast homolog of a DEAD-box ATP-dependent RNA helicase), suggesting functional similarity. Which disease is associated with this shared binding pa... | allergic asthma | Medium | convergence | {"qa_id":"medium_convergence_01110","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ALYREF and CSTF2T share a common binding partner. Evidence indicates that this shared partner interacts with the mRNA export factor Aly and can rescue the lo... | |
medium_convergence_01112 | EIF3B and EIF3C each share a binding partner. Evidence for one such shared partner indicates that it interacts directly with EIF3C, EIF3G, and EIF3J, as demonstrated by glutathione S-transferase pull-down assays. Which protein is encoded by this shared binding partner? | Eukaryotic translation initiation factor 3 subunit K | Medium | convergence | {"qa_id":"medium_convergence_01112","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF3B and EIF3C each share a binding partner. Evidence for one such shared partner indicates that it interacts directly with EIF3C, EIF3G, and EIF3J, as demo... | |
medium_convergence_01113 | Dengue virus and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) shows a log2 fold change of approximately -1.266 and an adjusted p-value of 0.03663. Which protein is encoded by this gene? | Zinc finger E-box-binding homeobox 1 | Medium | convergence | {"qa_id":"medium_convergence_01113","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) shows a log2 fold ... | |
medium_convergence_01114 | Both Human gammaherpesvirus 4 and Severe acute respiratory syndrome-related coronavirus are reported to downregulate a specific gene. Experimental data for this gene in gamma delta T-lymphocytes (from study GSE13906) show a log2 fold change of -1.523 and an adjusted p-value of 0.04481. Which protein is encoded by this ... | Sal-like protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01114","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human gammaherpesvirus 4 and Severe acute respiratory syndrome-related coronavirus are reported to downregulate a specific gene. Experimental data for t... | |
medium_convergence_01115 | MIR21 and MIR135B are both involved in more than one shared biological process. One such shared process is supported by evidence stating: 'We also found that miR-21 is essential for hypoxia-induced cell migration.' Which biological process is positively regulated by this shared entity? | vascular associated smooth muscle cell migration | Medium | convergence | {"qa_id":"medium_convergence_01115","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MIR21 and MIR135B are both involved in more than one shared biological process. One such shared process is supported by evidence stating: 'We also found that... | |
medium_convergence_01116 | BARD1 and BRCA1 both interact with a shared partner protein. Evidence for this interaction describes a bipartite mechanism: the UBA domain of the partner binds K6-linked polyubiquitin chains conjugated to BRCA1, while the C-terminal sequences of the partner bind the BRCA1/BARD1 heterodimer in a ubiquitin-independent ma... | VCP | Medium | convergence | {"qa_id":"medium_convergence_01116","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BARD1 and BRCA1 both interact with a shared partner protein. Evidence for this interaction describes a bipartite mechanism: the UBA domain of the partner bin... | |
medium_convergence_01117 | CHEK2 and SGO1 share multiple interacting partners. One such partner is identified in a study stating: 'To identify new regulators of this kinase, we performed a yeast two-hybrid screen and found that Chk2 associated with the B' regulatory subunit of protein phosphatase PP2A.' Which protein encodes the specific isoform... | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform | Medium | convergence | {"qa_id":"medium_convergence_01117","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK2 and SGO1 share multiple interacting partners. One such partner is identified in a study stating: 'To identify new regulators of this kinase, we perform... | |
medium_convergence_01118 | HIST1H2BB and HDAC1 share a common interacting partner. Evidence indicates that in response to DNA damage, this shared partner interacts with HDAC1 and specifically removes K63-linked ubiquitin chains, thereby promoting the deacetylase activity of HDAC1. Which protein is encoded by the gene corresponding to this shared... | Ubiquitin carboxyl-terminal hydrolase 38 | Medium | convergence | {"qa_id":"medium_convergence_01118","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HIST1H2BB and HDAC1 share a common interacting partner. Evidence indicates that in response to DNA damage, this shared partner interacts with HDAC1 and speci... | |
medium_convergence_01119 | Vaccinia virus and Human respirovirus 3 both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately 6.106 and an adjusted p-value of 0.000418. Which protein is encoded by this gene? | Lysosome-associated membrane glycoprotein 5 | Medium | convergence | {"qa_id":"medium_convergence_01119","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human respirovirus 3 both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE112... | |
medium_convergence_01120 | CHD3 and SIN3A both interact with a shared protein. Evidence indicates that this shared protein is associated with the corepressor mSin3A in murine erythroleukemia (MEL) and human T-ALL cells. Which protein is encoded by this shared entity? | T-cell acute lymphocytic leukemia protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01120","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD3 and SIN3A both interact with a shared protein. Evidence indicates that this shared protein is associated with the corepressor mSin3A in murine erythrole... | |
medium_convergence_01121 | PML and RUNX1 both interact with a shared protein partner. Evidence regarding this partner states: 'Using yeast two-hybrid screening, we demonstrate that Yes-associated protein (YAP) binds to the PY motif of PEBP2alpha through its WW domain.' Which protein is encoded by the gene corresponding to this shared partner? | Transcriptional coactivator YAP1 | Medium | convergence | {"qa_id":"medium_convergence_01121","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PML and RUNX1 both interact with a shared protein partner. Evidence regarding this partner states: 'Using yeast two-hybrid screening, we demonstrate that Yes... | |
medium_convergence_01122 | BIRC2 and IKBKG both physically interact with a common protein. Evidence regarding this shared partner states: 'In addition, Tax physically interacts with a mitogen-activated protein kinase kinase kinase and mediates the recruitment of IKK to this kinase.' Which disease is associated with this protein through genomic a... | cardiospondylocarpofacial syndrome | Medium | convergence | {"qa_id":"medium_convergence_01122","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC2 and IKBKG both physically interact with a common protein. Evidence regarding this shared partner states: 'In addition, Tax physically interacts with a ... | |
medium_convergence_01123 | RUVBL2 and SMG1 share common interaction partners. One of these shared partners is characterized by its ability to interact with and stabilize all six members of the PIKK family of proteins (mTOR, ATM, ATR, DNA-PKcs, SMG-1, and TRRAP). Which disease is associated with this specific shared partner? | neurodevelopmental disorder with microcephaly and movement abnormalities | Medium | convergence | {"qa_id":"medium_convergence_01123","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RUVBL2 and SMG1 share common interaction partners. One of these shared partners is characterized by its ability to interact with and stabilize all six member... | |
medium_convergence_01124 | AAK1 and AMPH both interact with a specific protein complex. Evidence regarding this shared partner states: 'They interact with dynamin and synaptojanin via their COOH-terminal SH3 domain, whereas their central regions contain binding sites for clathrin and for the clathrin adaptor AP-2.' Which gene encodes this shared... | AP-2 complex subunit beta | Medium | convergence | {"qa_id":"medium_convergence_01124","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AAK1 and AMPH both interact with a specific protein complex. Evidence regarding this shared partner states: 'They interact with dynamin and synaptojanin via ... | |
medium_convergence_01125 | CTNNB1 and PLK1 share multiple interacting partners. One such shared partner is characterized by evidence stating that it responds to the HER2 cascade by translocating into the nucleus following Ser273 phosphorylation, and subsequently contributes to cell mitosis regulation by binding with PLK1 to promote the phosphory... | non-classical monocyte | Medium | convergence | {"qa_id":"medium_convergence_01125","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and PLK1 share multiple interacting partners. One such shared partner is characterized by evidence stating that it responds to the HER2 cascade by tra... | |
medium_convergence_01126 | SORBS1 and EGFR share common interaction partners. One such partner is described in evidence stating: 'In human hepatoma Hep3B cells, SORBS1 was partly dissociated from the insulin receptor complex and bound to a tyrosine kinase protein upon insulin stimulation.' Which protein is encoded by this shared interaction part... | Tyrosine-protein kinase ABL1 | Medium | convergence | {"qa_id":"medium_convergence_01126","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SORBS1 and EGFR share common interaction partners. One such partner is described in evidence stating: 'In human hepatoma Hep3B cells, SORBS1 was partly disso... | |
medium_convergence_01127 | CHEK1 and MMS22L both interact with a specific protein component of the heterohexamic minichromosome maintenance (MCM) complex, as identified by mass spectrometry. Which protein is encoded by this shared interacting partner? | DNA replication licensing factor MCM2 | Medium | convergence | {"qa_id":"medium_convergence_01127","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK1 and MMS22L both interact with a specific protein component of the heterohexamic minichromosome maintenance (MCM) complex, as identified by mass spectro... | |
medium_convergence_01129 | Vaccinia virus and Dengue virus both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately 3.509 and an adjusted p-value of approximately 1.723e-08. Which protein is encoded by this gene? | TLC domain-containing protein 3A | Medium | convergence | {"qa_id":"medium_convergence_01129","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Dengue virus both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) repo... | |
medium_convergence_01130 | MTOR and MAPKAP1 share multiple binding partners. One such shared partner is a novel protein that defines a distinct complex with MTOR and is explicitly described as the 'rapamycin-insensitive companion of MTOR'. Which disease is associated with this specific protein via a biomarker relationship? | pediatric lymphoma | Medium | convergence | {"qa_id":"medium_convergence_01130","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MTOR and MAPKAP1 share multiple binding partners. One such shared partner is a novel protein that defines a distinct complex with MTOR and is explicitly desc... | |
medium_convergence_01131 | CDKN2A and VIRMA share common interacting partners. One such shared partner is characterized by proteomics analysis showing its interaction with p19(ARF), a tumor suppressor that competitively inhibits the partner's interaction with p53 when overexpressed. Which disease is associated with this specific shared partner? | infectious mononucleosis | Medium | convergence | {"qa_id":"medium_convergence_01131","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDKN2A and VIRMA share common interacting partners. One such shared partner is characterized by proteomics analysis showing its interaction with p19(ARF), a ... | |
medium_convergence_01132 | CDC37 and MAP3K5 both interact with a specific shared protein. Evidence indicates that mutating key basic amino acids (K97A and R101A) in the tetratricopeptide repeat (TPR) region of this protein abolishes its interaction with CDC37. Which protein is encoded by the gene corresponding to this shared entity? | Serine/threonine-protein phosphatase 5 | Medium | convergence | {"qa_id":"medium_convergence_01132","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDC37 and MAP3K5 both interact with a specific shared protein. Evidence indicates that mutating key basic amino acids (K97A and R101A) in the tetratricopepti... | |
medium_convergence_01133 | Human betaherpesvirus 5 and Rhinovirus A both upregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (study GSE111036) reports a log2 fold change of 2.439 and an adjusted p-value of 0.04992. Which protein is encoded by this gene? | snRNA-activating protein complex subunit 1 | Medium | convergence | {"qa_id":"medium_convergence_01133","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Rhinovirus A both upregulate a specific gene. Experimental data for this gene in foreskin fibroblast cell lines (study GSE111036)... | |
medium_convergence_01134 | FANCA and FAAP100 each interact with more than one shared protein partner. Evidence concerning one such shared entity reports that this protein is a component of a nuclear protein complex containing FANCA and FANCC. Which protein is encoded by this shared entity? | Fanconi anemia group G protein | Medium | convergence | {"qa_id":"medium_convergence_01134","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCA and FAAP100 each interact with more than one shared protein partner. Evidence concerning one such shared entity reports that this protein is a componen... | |
medium_convergence_01135 | F8 and LMAN1 share a common binding partner. Evidence indicates that this shared partner is localized to the ERGIC through a direct, calcium-dependent interaction with LMAN1. Which molecular function is enabled by this shared partner? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_01135","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"F8 and LMAN1 share a common binding partner. Evidence indicates that this shared partner is localized to the ERGIC through a direct, calcium-dependent intera... | |
medium_convergence_01137 | CAVIN1 and CCNH both interact with a specific protein. Evidence regarding this protein states: 'Here we report the isolation and characterization of three distinct CAK-containing complexes from HeLa nuclear extracts: CAK, a novel CAK-[protein] complex, and TFIIH.' Which disease is associated with this protein via a bio... | Cockayne syndrome type 2 | Medium | convergence | {"qa_id":"medium_convergence_01137","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CAVIN1 and CCNH both interact with a specific protein. Evidence regarding this protein states: 'Here we report the isolation and characterization of three di... | |
medium_convergence_01138 | H2AX and HIST3H3 each interact with more than one shared protein. Evidence concerning one shared entity reports that this entity forms complexes with phosphorylated H2AX. Which protein is connected to that entity through the 'encodes' relation? | Mediator of DNA damage checkpoint protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01138","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"H2AX and HIST3H3 each interact with more than one shared protein. Evidence concerning one shared entity reports that this entity forms complexes with phospho... | |
medium_convergence_01139 | PARP1 and MEN1 share multiple interacting partners. One such shared partner is identified in a study where Immunoprecipitation and Western blot analyses demonstrated that Cenpa, Cenpb, and this specific entity, but not Cenpc, interacted with PARP-1 and were poly(ADP-ribosyl)ated following the induction of DNA damage. W... | Mitotic checkpoint protein BUB3 | Medium | convergence | {"qa_id":"medium_convergence_01139","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and MEN1 share multiple interacting partners. One such shared partner is identified in a study where Immunoprecipitation and Western blot analyses demo... | |
medium_convergence_01140 | CHD4 and FBXO32 share a common interacting partner. Evidence indicates that FBXO32 directly ubiquitinates this shared partner, a process required for the partner's stability and nuclear retention. Which disease is associated with this shared partner via a biomarker relationship? | osteosarcoma | Medium | convergence | {"qa_id":"medium_convergence_01140","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHD4 and FBXO32 share a common interacting partner. Evidence indicates that FBXO32 directly ubiquitinates this shared partner, a process required for the par... | |
medium_convergence_01141 | DLL1 and DLL4 both interact with a specific receptor protein. Experimental evidence indicates that three DSL proteins bind to endogenous levels of this receptor on the surface of BaF3 cells, although the binding characteristics of Jagged2 to this receptor differed from those of Delta1 and Jagged1. Which protein is enco... | Neurogenic locus notch homolog protein 2 | Medium | convergence | {"qa_id":"medium_convergence_01141","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLL1 and DLL4 both interact with a specific receptor protein. Experimental evidence indicates that three DSL proteins bind to endogenous levels of this recep... | |
medium_convergence_01142 | Both Human immunodeficiency virus 1 and Dengue virus are known to downregulate a specific gene. Experimental data from a study on macrophages (GSE108897) indicates that this gene exhibits a log2 fold change of approximately -2.44 and an adjusted p-value of 0.00011. Which protein interacts with this downregulated gene? | LONP1 | Medium | convergence | {"qa_id":"medium_convergence_01142","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Dengue virus are known to downregulate a specific gene. Experimental data from a study on macrophages (GSE108897) ind... | |
medium_convergence_01143 | DIS3 and DCP1A both interact with a shared protein. Evidence regarding this shared entity states: 'Here, we demonstrate the association of two different Dis3p homologs--hDIS3 and hDIS3L--with the human exosome core.' Which cell type is enriched for this shared entity? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_01143","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DIS3 and DCP1A both interact with a shared protein. Evidence regarding this shared entity states: 'Here, we demonstrate the association of two different Dis3... | |
medium_convergence_01144 | ARPC1A and NCK1 both interact with a shared protein partner. Experimental evidence indicates that Nck binds to this partner through its second SH3 domain at a site spanning amino acids 321-415, which is distinct from the binding site for WASP (amino acids 416-488). Which disease is associated with this shared protein p... | Wiskott-Aldrich syndrome 2 | Medium | convergence | {"qa_id":"medium_convergence_01144","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARPC1A and NCK1 both interact with a shared protein partner. Experimental evidence indicates that Nck binds to this partner through its second SH3 domain at ... | |
medium_convergence_01145 | SMAD1 and BMPR1B both interact with a specific inhibitory Smad protein. Evidence indicates that this protein specifically competes with Smad4 for binding to receptor-activated Smad1, resulting in the formation of an apparently inactive Smad1-protein complex. Which gene encodes this inhibitory Smad protein? | SMAD family member 6 | Medium | convergence | {"qa_id":"medium_convergence_01145","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD1 and BMPR1B both interact with a specific inhibitory Smad protein. Evidence indicates that this protein specifically competes with Smad4 for binding to ... | |
medium_convergence_01146 | CDK2 and CDC20 share common binding partners. One such shared partner is implicated in a mechanism where mammalian cyclin A prevents unscheduled APC reactivation during S phase by interacting with a specific anaphase-promoting complex cofactor. Which disease is associated with this specific shared partner? | developmental and epileptic encephalopathy 109 | Medium | convergence | {"qa_id":"medium_convergence_01146","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK2 and CDC20 share common binding partners. One such shared partner is implicated in a mechanism where mammalian cyclin A prevents unscheduled APC reactiva... | |
medium_convergence_01147 | JOSD2 and ENO1 both interact with a shared protein. Evidence for one of these shared interactors states: 'Next, [REDACTED] is identified as a novel interaction protein of JOSD2 by mass spectrometry, co-immunoprecipitation and co-immunofluorescence in HL60 cells.' Which protein is encoded by this specific shared interac... | Pyruvate kinase PKM | Medium | convergence | {"qa_id":"medium_convergence_01147","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"JOSD2 and ENO1 both interact with a shared protein. Evidence for one of these shared interactors states: 'Next, [REDACTED] is identified as a novel interacti... | |
medium_convergence_01148 | TRAF1 and TRAF3 each interact with more than one shared protein. Evidence concerning one such shared entity reports that a TNF receptor superfamily member associates with TRAF1, TRAF2, and this entity, and induces nuclear factor (NF)-kappaB activation via TRAF2. Which protein is encoded by the gene corresponding to tha... | Tumor necrosis factor receptor superfamily member 18 | Medium | convergence | {"qa_id":"medium_convergence_01148","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRAF1 and TRAF3 each interact with more than one shared protein. Evidence concerning one such shared entity reports that a TNF receptor superfamily member as... | |
medium_convergence_01149 | HDAC1 and HDAC2 share interaction partners. One such shared partner is described in the following context: 'Here, we show that this transcription factor is associated with histone demethylase complexes containing lysine-specific demethylase 1 (LSD1), RE1 silencing transcription factor corepressor (CoREST), histone deac... | leukemia, acute lymphocytic, susceptibility to, 1 | Medium | convergence | {"qa_id":"medium_convergence_01149","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and HDAC2 share interaction partners. One such shared partner is described in the following context: 'Here, we show that this transcription factor is a... | |
medium_convergence_01150 | CENPS and CENPK each interact with more than one shared protein partner. Evidence concerning one such shared entity reports that Fluorescent two-hybrid analysis identified a uniquely strong CENP-S binding protein, and this association was confirmed by FRET, revealing a centromere-bound complex containing CENP-S, CENP-X... | Centromere protein T | Medium | convergence | {"qa_id":"medium_convergence_01150","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPS and CENPK each interact with more than one shared protein partner. Evidence concerning one such shared entity reports that Fluorescent two-hybrid analy... | |
medium_convergence_01151 | ADRM1 and PSMA4 each share a binding partner. Evidence concerning one such shared partner states: 'In the present study, we demonstrate that the 20S proteasome subunits alpha4 and alpha7 interact with each other as well as all the alpha-subunits in vivo and in vitro.' Which protein is encoded by the gene corresponding ... | Proteasome subunit alpha type-7 | Medium | convergence | {"qa_id":"medium_convergence_01151","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ADRM1 and PSMA4 each share a binding partner. Evidence concerning one such shared partner states: 'In the present study, we demonstrate that the 20S proteaso... | |
medium_convergence_01152 | CUL3 and AURKB each interact with more than one shared protein partner. Evidence concerning one of these shared partners reports that Aurora B directly binds to the substrate-recognition domain of this entity in vitro and coimmunoprecipitates with the CUL3 complex during mitosis. Which protein is encoded by the gene co... | Kelch-like protein 9 | Medium | convergence | {"qa_id":"medium_convergence_01152","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CUL3 and AURKB each interact with more than one shared protein partner. Evidence concerning one of these shared partners reports that Aurora B directly binds... | |
medium_convergence_01153 | CHMP4B and TSG101 each interact with more than one shared partner. Evidence concerning one shared entity reports: 'Specifically, a VPS36 homolog bound ubiquitin via its N-terminal GRAM-like ubiquitin-binding domain, both this homolog and EAP30 bound the C-terminal domain of TSG101/ESCRT-I, and EAP20 bound the N-termina... | lipoma | Medium | convergence | {"qa_id":"medium_convergence_01153","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHMP4B and TSG101 each interact with more than one shared partner. Evidence concerning one shared entity reports: 'Specifically, a VPS36 homolog bound ubiqui... | |
medium_convergence_01154 | Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. In a study using a cervical adenocarcinoma cell line (GSE11238), this gene exhibited a log2 fold change of approximately -1.38 and an adjusted p-value of 0.0356. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_01154","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human betaherpesvirus 5 both downregulate a specific gene. In a study using a cervical adenocarcinoma cell line (GSE11238), this gene exhi... | |
medium_convergence_01155 | CBX8 and BMI1 both interact with a specific polycomb group protein. Experimental evidence indicates that HPH1 and a homologous protein coimmunoprecipitate and cofractionate with this protein. Which cell type is this protein enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_01155","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBX8 and BMI1 both interact with a specific polycomb group protein. Experimental evidence indicates that HPH1 and a homologous protein coimmunoprecipitate an... | |
medium_convergence_01156 | Human alphaherpesvirus 1 and Hepacivirus C both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) shows a log2 fold change of -1.496 and an adjusted p-value of 0.002615. Which disease is associated with this gene as a biomarker? | breast cancer | Medium | convergence | {"qa_id":"medium_convergence_01156","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Hepacivirus C both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114... | |
medium_convergence_01157 | STRA6 and BMP4 are both involved in multiple shared biological processes. One of these shared processes is supported by evidence stating: 'Our findings support a critical role for BMPs in lung vasculogenesis.' Which biological process is this shared entity a part of? | lung development | Medium | convergence | {"qa_id":"medium_convergence_01157","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STRA6 and BMP4 are both involved in multiple shared biological processes. One of these shared processes is supported by evidence stating: 'Our findings suppo... | |
medium_convergence_01158 | NEDD4 and YWHAB both interact with a common protein. Evidence regarding this shared interaction partner states: 'The PY (Pro-Tyr) motif of this protein binds to WW (Trp-Trp) domains of NEDD4.' Which protein is encoded by the gene corresponding to this shared interaction partner? | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4 | Medium | convergence | {"qa_id":"medium_convergence_01158","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NEDD4 and YWHAB both interact with a common protein. Evidence regarding this shared interaction partner states: 'The PY (Pro-Tyr) motif of this protein binds... | |
medium_convergence_01159 | GNAI1 and GNAO1 both interact with a specific shared protein partner. Experimental evidence indicates that immunoprecipitation of this shared protein partner in transfected cells leads to the co-precipitation of G(i) alpha 1 and G(i) alpha 3 polypeptides. Which disease is associated with this shared protein partner via... | diabetes mellitus | Medium | convergence | {"qa_id":"medium_convergence_01159","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNAI1 and GNAO1 both interact with a specific shared protein partner. Experimental evidence indicates that immunoprecipitation of this shared protein partner... | |
medium_convergence_01160 | Both POLR2A and POLR2I interact with a shared gene product. Evidence indicates that the interaction between this shared entity and RNA Polymerase II is direct and mediated by the RPB1 subunit. Which disease is associated with this entity via a biomarker relationship? | colon carcinoma | Medium | convergence | {"qa_id":"medium_convergence_01160","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both POLR2A and POLR2I interact with a shared gene product. Evidence indicates that the interaction between this shared entity and RNA Polymerase II is direc... | |
medium_convergence_01161 | TRAF2 and TRAF3 both interact with a specific shared receptor protein. Evidence indicates that a specific TNF receptor superfamily member associates with TRAF1, this shared receptor, and TRAF3, and induces nuclear factor (NF)-kappaB activation specifically via TRAF2. Which disease is connected to this shared receptor t... | lymphoma | Medium | convergence | {"qa_id":"medium_convergence_01161","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRAF2 and TRAF3 both interact with a specific shared receptor protein. Evidence indicates that a specific TNF receptor superfamily member associates with TRA... | |
medium_convergence_01162 | PIAS3 and FHL3 both interact with a specific shared protein. Experimental evidence indicates that PIAS3 interacts with Smad proteins, with the strongest interaction observed with this specific shared entity. Which gene encodes this protein? | SMAD family member 3 | Medium | convergence | {"qa_id":"medium_convergence_01162","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PIAS3 and FHL3 both interact with a specific shared protein. Experimental evidence indicates that PIAS3 interacts with Smad proteins, with the strongest inte... | |
medium_convergence_01164 | DYNLL1 and BECN1 share multiple binding partners. One such shared partner is a protein whose depletion leads to Nedd4-mediated proteasomal degradation of Beclin 1 via Lys11-linked polyubiquitin chains. Which disease is associated with this shared partner as a biomarker? | bipolar disorder | Medium | convergence | {"qa_id":"medium_convergence_01164","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DYNLL1 and BECN1 share multiple binding partners. One such shared partner is a protein whose depletion leads to Nedd4-mediated proteasomal degradation of Bec... | |
medium_convergence_01165 | MCRS1 and YWHAQ both interact with a shared protein. Evidence indicates that 14-3-3 signaling proteins are binding partners of this shared entity (specifically referred to as h[entity]). Which protein is encoded by this shared entity? | Telomerase reverse transcriptase | Medium | convergence | {"qa_id":"medium_convergence_01165","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MCRS1 and YWHAQ both interact with a shared protein. Evidence indicates that 14-3-3 signaling proteins are binding partners of this shared entity (specifical... | |
medium_convergence_01166 | Measles morbillivirus and Cardiovirus A both downregulate a specific gene. Evidence for this gene in study GSE131840 reports a log2 fold change of -1.379 and an adjusted p-value of 0.02209. Which cell type is this gene enriched in? | basophil | Medium | convergence | {"qa_id":"medium_convergence_01166","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Measles morbillivirus and Cardiovirus A both downregulate a specific gene. Evidence for this gene in study GSE131840 reports a log2 fold change of -1.379 and... | |
medium_convergence_01167 | HSP90AA1 and HSP90AB1 both interact with a shared protein entity. Evidence regarding this entity states: 'Functional inhibition of Hsp90 by the anti-tumor agent geldanamycin (GA) efficiently disrupts its interaction with a kinase involved in NF-kappaB signaling, resulting in its degradation and subsequent blockage of p... | diabetes mellitus | Medium | convergence | {"qa_id":"medium_convergence_01167","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSP90AA1 and HSP90AB1 both interact with a shared protein entity. Evidence regarding this entity states: 'Functional inhibition of Hsp90 by the anti-tumor ag... | |
medium_convergence_01168 | HIPK2 and the androgen receptor (AR) both interact with a specific shared protein. Evidence indicates that HIPK2 directly binds to this shared protein as well as c-Ski. Which protein is encoded by this shared entity? | SMAD family member 1 | Medium | convergence | {"qa_id":"medium_convergence_01168","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HIPK2 and the androgen receptor (AR) both interact with a specific shared protein. Evidence indicates that HIPK2 directly binds to this shared protein as wel... | |
medium_convergence_01169 | Both Vaccinia virus and Influenza A virus are known to downregulate a specific shared gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately -1.55 and an adjusted p-value of 8.709e-06. Which disease is associated with this gene as a biom... | schizophrenia | Medium | convergence | {"qa_id":"medium_convergence_01169","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Vaccinia virus and Influenza A virus are known to downregulate a specific shared gene. Experimental data for this gene in a cervical adenocarcinoma cell... | |
medium_convergence_01171 | IRGM and ATG16L1 both interact with a specific protein. Evidence indicates that this protein, along with autophagy proteins IRGM and p62/SQSTM1, physically interacts with NOD1/2 and RIPosomes to promote their selective autophagy and limit NF-κB activation. Which protein is encoded by the gene corresponding to this inte... | Receptor-interacting serine/threonine-protein kinase 2 | Medium | convergence | {"qa_id":"medium_convergence_01171","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IRGM and ATG16L1 both interact with a specific protein. Evidence indicates that this protein, along with autophagy proteins IRGM and p62/SQSTM1, physically i... | |
medium_convergence_01172 | COPG1 and BET1L each share a binding partner with another protein. Evidence concerning one of these shared partners states: 'Yeast two-hybrid analysis indicates that gamma1- and gamma2-COPs can directly, albeit promiscuously, interact with zeta1- and zeta2-COPs.' Which protein is connected to that specific shared partn... | Coatomer subunit zeta-1 | Medium | convergence | {"qa_id":"medium_convergence_01172","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPG1 and BET1L each share a binding partner with another protein. Evidence concerning one of these shared partners states: 'Yeast two-hybrid analysis indica... | |
medium_convergence_01173 | YWHAQ and YWHAG both interact with a specific protein. Evidence for this protein states: 'We demonstrate direct and robust interaction between h[protein] and six of the seven 14-3-3 isoforms in vitro, suggestive of a novel protein interaction network between DNA repair and cell cycle control.' Which cellular component ... | nucleus | Medium | convergence | {"qa_id":"medium_convergence_01173","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YWHAQ and YWHAG both interact with a specific protein. Evidence for this protein states: 'We demonstrate direct and robust interaction between h[protein] and... | |
medium_convergence_01174 | ABRAXAS2 and FAM175A each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'Finally, we also show that Abro1, another BRISC subunit, binds directly to this protein and that the heterodimer formed by this protein and Abro1 includes a minimal complex with Lys(63... | leiomyoma | Medium | convergence | {"qa_id":"medium_convergence_01174","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ABRAXAS2 and FAM175A each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'Finally, we also show... | |
medium_convergence_01175 | Zaire ebolavirus and Zika virus both downregulate a specific gene. Evidence for this gene in retinal pigment epithelium cells (study GSE100839) reports a log2 fold change of approximately -1.018 and an adjusted p-value of 0.0001369. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_01175","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Zaire ebolavirus and Zika virus both downregulate a specific gene. Evidence for this gene in retinal pigment epithelium cells (study GSE100839) reports a log... | |
medium_convergence_01176 | CTBP1 and CTBP2 both interact with a shared protein complex component. Evidence indicates that HDAC1/2, a corepressor protein encoded by RCOR1, LSD1, and Ubc9 (E2) are core constituents of this complex, interacting with the PLDLS cleft region through non-PLDLS interactions. Which biological process is this shared entit... | negative regulation of DNA-templated transcription | Medium | convergence | {"qa_id":"medium_convergence_01176","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTBP1 and CTBP2 both interact with a shared protein complex component. Evidence indicates that HDAC1/2, a corepressor protein encoded by RCOR1, LSD1, and Ubc... | |
medium_convergence_01177 | CTSS and EFEMP1 share multiple interacting partners. One specific shared partner is part of a set of eight interactions (including ANXA5, ERdj5, PDIA4, P4HB, PDIA6, and TXNDC5) that were verified at the western blotting level. Which protein is encoded by this specific shared partner? | Stromal cell-derived factor 2-like protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01177","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTSS and EFEMP1 share multiple interacting partners. One specific shared partner is part of a set of eight interactions (including ANXA5, ERdj5, PDIA4, P4HB,... | |
medium_convergence_01178 | Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental data from a study on lung fibroblast cell lines (GSE120891) indicates that this gene exhibits a log2 fold change of approximately 2.155 and an adjusted p-value of 0... | Serine hydroxymethyltransferase, mitochondrial | Medium | convergence | {"qa_id":"medium_convergence_01178","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental d... | |
medium_convergence_01179 | POLR2A and PPARG both interact with a specific shared protein. Experimental evidence indicates that RNA Polymerase II binds to this shared protein in a ligand-dependent manner. Which protein is encoded by the gene corresponding to this shared interaction partner? | Vitamin D3 receptor | Medium | convergence | {"qa_id":"medium_convergence_01179","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"POLR2A and PPARG both interact with a specific shared protein. Experimental evidence indicates that RNA Polymerase II binds to this shared protein in a ligan... | |
medium_convergence_01180 | H2AX and ATR both interact with a shared protein. Evidence regarding this shared protein states: 'In this study we solve the crystal structures of the natural variant (A761) C-terminal tandem BRCT domains alone as well as in complex with γH2AX tail.' Which protein is encoded by this shared entity? | Microcephalin | Medium | convergence | {"qa_id":"medium_convergence_01180","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"H2AX and ATR both interact with a shared protein. Evidence regarding this shared protein states: 'In this study we solve the crystal structures of the natura... | |
medium_convergence_01181 | EGFR and EPHA2 share a common interaction partner. Experimental evidence indicates that this shared partner interacts with both Cbl and EGFR. Which gene is connected to this shared partner through a 'binds' relationship? | LRFN3 | Medium | convergence | {"qa_id":"medium_convergence_01181","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and EPHA2 share a common interaction partner. Experimental evidence indicates that this shared partner interacts with both Cbl and EGFR. Which gene is c... | |
medium_convergence_01182 | Both IL17RB and TSLP are involved in multiple shared biological processes. One of these shared processes is characterized by an activity that, like IL-25, depends on the IL-17RA and IL-17RB receptor subunits. Which biological process is this, and what specific production process does it positively regulate? | interleukin-5 production | Medium | convergence | {"qa_id":"medium_convergence_01182","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both IL17RB and TSLP are involved in multiple shared biological processes. One of these shared processes is characterized by an activity that, like IL-25, de... | |
medium_convergence_01183 | GRB2 and PTPN11 both interact with a specific shared protein. Evidence indicates that reduced EGF-stimulated activation of PI3-K was mediated by interactions between the carboxyl terminus of this shared protein (specifically the SIRPalpha1 isoform) and the Src homology-2 (SH2)-containing phosphotyrosine phosphatase, SH... | SKAP2 | Medium | convergence | {"qa_id":"medium_convergence_01183","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRB2 and PTPN11 both interact with a specific shared protein. Evidence indicates that reduced EGF-stimulated activation of PI3-K was mediated by interactions... | |
medium_convergence_01184 | HDAC2 and MYC share multiple interacting partners. One such shared partner is reported to directly interact with MYC and co-occupy a distal regulatory element of SOX2 to activate SOX2 expression, a mechanism likely involved in neuroectoderm differentiation. Which protein is encoded by this shared partner? | Polycomb group RING finger protein 6 | Medium | convergence | {"qa_id":"medium_convergence_01184","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC2 and MYC share multiple interacting partners. One such shared partner is reported to directly interact with MYC and co-occupy a distal regulatory elemen... | |
medium_convergence_01185 | Both Human alphaherpesvirus 3 and Zaire ebolavirus are known to downregulate a specific gene. Experimental data from a melanoma cell line study (GSE136586) indicates that this gene exhibits a log2 fold change of -1.386 and an adjusted p-value of 1.824e-07. Which disease is associated with this gene? | acute leukemia | Medium | convergence | {"qa_id":"medium_convergence_01185","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Zaire ebolavirus are known to downregulate a specific gene. Experimental data from a melanoma cell line study (GSE136586) i... | |
medium_convergence_01186 | ADRB2 and NEDD4L both interact with a shared protein. Evidence regarding this shared entity states: 'Further evidence for the importance of this protein in this process comes from the ability of Nedd4-2 to bind to it.' Which protein is encoded by this shared entity? | Serine/threonine-protein kinase WNK1 | Medium | convergence | {"qa_id":"medium_convergence_01186","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ADRB2 and NEDD4L both interact with a shared protein. Evidence regarding this shared entity states: 'Further evidence for the importance of this protein in t... | |
medium_convergence_01187 | CAND1 and CUL1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'To begin to characterize the biochemical function of this protein, we used proteomic analysis to demonstrate that it interacts with Skp1 (SKP1), Cullin1 (CUL1), Ring-box1 (RBX1) and all components of the COP9... | trisomy | Medium | convergence | {"qa_id":"medium_convergence_01187","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CAND1 and CUL1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'To begin to characterize the biochemical func... | |
medium_convergence_01188 | Human polyomavirus 1 and Enterovirus A both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) reports a log2 fold change of 2.579 and an adjusted p-value of 0.01794. Which protein is encoded by this gene? | Prospero homeobox protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01188","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Enterovirus A both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) reports a... | |
medium_convergence_01189 | ESCO2 and VIRMA share interaction partners. One such shared partner is distinguished by the fact that ESCO2, but not ESCO1, interacts with the MCM complex through a unique ESCO2 domain. Which protein is encoded by this shared partner? | DNA replication licensing factor MCM4 | Medium | convergence | {"qa_id":"medium_convergence_01189","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESCO2 and VIRMA share interaction partners. One such shared partner is distinguished by the fact that ESCO2, but not ESCO1, interacts with the MCM complex th... | |
medium_convergence_01190 | CCL5 and CCL21 both interact with a specific chemokine receptor. Experimental evidence indicates that a triple 40s mutant exhibits an 80-fold reduction in affinity for this receptor, while maintaining normal binding to CCR5. Which protein is encoded by the gene corresponding to this receptor? | C-C chemokine receptor type 1 | Medium | convergence | {"qa_id":"medium_convergence_01190","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CCL5 and CCL21 both interact with a specific chemokine receptor. Experimental evidence indicates that a triple 40s mutant exhibits an 80-fold reduction in af... | |
medium_convergence_01191 | DOCK1 and CD3G each interact with more than one shared protein partner. Evidence concerning one such shared partner indicates that a specific complex binds directly to CED-5/DOCK1; this evolutionarily conserved complex stimulates a Rac-GEF, leading to Rac1 activation and cytoskeletal rearrangements. Which protein is en... | Engulfment and cell motility protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01191","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DOCK1 and CD3G each interact with more than one shared protein partner. Evidence concerning one such shared partner indicates that a specific complex binds d... | |
medium_convergence_01192 | HDAC6 and EP300 both interact with a specific shared protein. Evidence indicates that this shared protein is acetylated at Lysine 160 by the acetyltransferase p300/CREB binding protein (CBP) through direct protein interaction, a process that stimulates the acetylation and catalytic activity of p300/CBP. Which protein i... | Glyceraldehyde-3-phosphate dehydrogenase | Medium | convergence | {"qa_id":"medium_convergence_01192","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC6 and EP300 both interact with a specific shared protein. Evidence indicates that this shared protein is acetylated at Lysine 160 by the acetyltransferas... | |
medium_convergence_01193 | KCNE5 and YWHAE are both involved in more than one shared biological process. One shared process is supported by evidence stating: 'Here we show that KCNE5 induces both a time- and voltage-dependent modulation of the KCNQ1 current.' Which biological process, connected to this entity via the 'regulates' relationship, co... | potassium ion transmembrane transport | Medium | convergence | {"qa_id":"medium_convergence_01193","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KCNE5 and YWHAE are both involved in more than one shared biological process. One shared process is supported by evidence stating: 'Here we show that KCNE5 i... | |
medium_convergence_01194 | FOXK2 and ASXL2 both interact with a common protein partner. Evidence indicates that BAP1 recruits a host cell factor to form a ternary complex, where BAP1 serves as a bridge between this shared partner and the host cell factor. Which protein is encoded by the gene corresponding to this shared partner? | Host cell factor 1 | Medium | convergence | {"qa_id":"medium_convergence_01194","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FOXK2 and ASXL2 both interact with a common protein partner. Evidence indicates that BAP1 recruits a host cell factor to form a ternary complex, where BAP1 s... | |
medium_convergence_01195 | RAD51 and EXO1 both interact with a common protein partner. Experimental evidence indicates that phosphorylation of this shared partner by c-Abl enhances its complex formation with RAD51, a process that cooperates with RAD51 in recombination and repair. Which protein is encoded by the gene corresponding to this shared ... | DNA repair protein RAD52 homolog | Medium | convergence | {"qa_id":"medium_convergence_01195","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAD51 and EXO1 both interact with a common protein partner. Experimental evidence indicates that phosphorylation of this shared partner by c-Abl enhances its... | |
medium_convergence_01196 | ARPC2 and AP2A2 both interact with a shared protein entity. Evidence indicates that a site in the ankle domain of the clathrin triskelion leg binds to a common site on the appendages of tetrameric AP1 and AP2 adaptors, as well as monomeric GGA1 adaptors. Which protein is encoded by the gene corresponding to this shared... | Clathrin heavy chain 1 | Medium | convergence | {"qa_id":"medium_convergence_01196","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARPC2 and AP2A2 both interact with a shared protein entity. Evidence indicates that a site in the ankle domain of the clathrin triskelion leg binds to a comm... | |
medium_convergence_01197 | ARPC4 and NCK1 both interact with a shared protein. Evidence regarding this shared protein states: 'Studies in vivo and in vitro demonstrated a highly specific interaction between the SH3 domains of p47nck and Wiskott-Aldrich syndrome protein.' Which protein is encoded by this shared entity? | Actin nucleation-promoting factor WAS | Medium | convergence | {"qa_id":"medium_convergence_01197","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARPC4 and NCK1 both interact with a shared protein. Evidence regarding this shared protein states: 'Studies in vivo and in vitro demonstrated a highly specif... | |
medium_convergence_01198 | ERCC3 and TBP each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Coimmunoprecipitation studies using an antibody to a specific transcription factor demonstrated that TATA-binding protein, a subunit of SL-1, associates with this factor in the absence of DNA.' Which protein i... | Nucleolar transcription factor 1 | Medium | convergence | {"qa_id":"medium_convergence_01198","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERCC3 and TBP each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Coimmunoprecipitation studies using an antibod... | |
medium_convergence_01199 | RAD50 and EP300 both interact with a shared protein. Contextual evidence indicates that this shared protein associates with the acetyltransferase p300 and is required for efficient transcriptional activation of the p53 target gene p21 by affecting the acetylation of p53 at lysine 382. Which protein is encoded by this s... | SOSS complex subunit B1 | Medium | convergence | {"qa_id":"medium_convergence_01199","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAD50 and EP300 both interact with a shared protein. Contextual evidence indicates that this shared protein associates with the acetyltransferase p300 and is... |
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