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medium_convergence_00984 | Human alphaherpesvirus 1 and Rhinovirus A both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately 2.93 and an adjusted p-value of approximately 0.0093. Which protein is encoded by this gene? | Hyaluronan mediated motility receptor | Medium | convergence | {"qa_id":"medium_convergence_00984","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Rhinovirus A both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966... | |
medium_convergence_00985 | FBXO32 and HDAC1 both interact with a specific shared protein. Evidence regarding this shared entity states: 'Here we report that the myogenic transcription factor interacts with Atrogin-1/MAFbx (MAFbx), a striated muscle-specific E3 ubiquitin ligase dramatically up-regulated in atrophying muscle.' Which protein is enc... | Myoblast determination protein 1 | Medium | convergence | {"qa_id":"medium_convergence_00985","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FBXO32 and HDAC1 both interact with a specific shared protein. Evidence regarding this shared entity states: 'Here we report that the myogenic transcription ... | |
medium_convergence_00986 | F2 and BRAF both interact with a shared protein kinase that activates MEKs. Evidence states: 'Members of the raf oncogene family encode serine/threonine protein kinases, which activate the mitogen-activated protein kinase kinase MEKs (MAPK or ERK kinases) through direct interaction and phosphorylation.' Another piece o... | Dual specificity mitogen-activated protein kinase kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_00986","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"F2 and BRAF both interact with a shared protein kinase that activates MEKs. Evidence states: 'Members of the raf oncogene family encode serine/threonine prot... | |
medium_convergence_00987 | EHMT2 and DNMT3A share a common interaction partner. Evidence indicates that this shared partner binds the histone lysine methyltransferase G9a and co-localizes with it in the nucleus in a cell-cycle-dependent manner. Which protein is encoded by this shared interaction partner? | E3 ubiquitin-protein ligase UHRF1 | Medium | convergence | {"qa_id":"medium_convergence_00987","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EHMT2 and DNMT3A share a common interaction partner. Evidence indicates that this shared partner binds the histone lysine methyltransferase G9a and co-locali... | |
medium_convergence_00988 | CSNK2B and HSP90AA1 both interact with a shared protein. Experimental evidence for this protein describes a procedure where p210 (the fusion protein containing this entity) and its molecular chaperones were co-immunoprecipitated, followed by Western blot analysis using antibodies against Hsp90, Hsp70, p23, and p60(Hop)... | gamma-delta T cell | Medium | convergence | {"qa_id":"medium_convergence_00988","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2B and HSP90AA1 both interact with a shared protein. Experimental evidence for this protein describes a procedure where p210 (the fusion protein containi... | |
medium_convergence_00990 | HDAC2 and SMAD3 both interact with a shared protein. Evidence regarding this shared entity states: 'The association of Smads and HDAC1 is mediated in part by direct binding of Smads to the HDAC1-associated proteins, TG-interacting factor, c-ski, and SnoN.' Which protein is encoded by the gene corresponding to this shar... | Homeobox protein TGIF1 | Medium | convergence | {"qa_id":"medium_convergence_00990","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC2 and SMAD3 both interact with a shared protein. Evidence regarding this shared entity states: 'The association of Smads and HDAC1 is mediated in part by... | |
medium_convergence_00991 | EXOSC8 and DCP1A share common binding partners. One such shared partner is characterized by the following evidence: Mutation of six C-terminal lysines of this entity suppresses decapping activity and impairs its interaction with the mRNA decay factors DCP2, EDC4, and the entity itself, but not EDC3, thereby remodeling ... | 5'-3' exoribonuclease 1 | Medium | convergence | {"qa_id":"medium_convergence_00991","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EXOSC8 and DCP1A share common binding partners. One such shared partner is characterized by the following evidence: Mutation of six C-terminal lysines of thi... | |
medium_convergence_00992 | MXD1 and ARID4B both interact with a common protein partner. Experimental evidence indicates that the HBP1 transrepression domain binds to the hydrophobic cleft of the PAH2 domain of this shared partner, a mechanism similar to that of Mad1. Which protein is encoded by this shared partner? | Paired amphipathic helix protein Sin3a | Medium | convergence | {"qa_id":"medium_convergence_00992","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MXD1 and ARID4B both interact with a common protein partner. Experimental evidence indicates that the HBP1 transrepression domain binds to the hydrophobic cl... | |
medium_convergence_00993 | CRK and ERBB3 share a common interaction partner. Evidence indicates that this partner possesses kinase activity, binds to the first SH3 domain of Crk, and phosphorylates c-Crk on tyrosine 221 (Y221), functioning as c-Abl. Which disease is associated with this entity through genomic alterations? | MELAS syndrome | Medium | convergence | {"qa_id":"medium_convergence_00993","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRK and ERBB3 share a common interaction partner. Evidence indicates that this partner possesses kinase activity, binds to the first SH3 domain of Crk, and p... | |
medium_convergence_00994 | DLG4 and SLC1A6 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'We identified four PDZ domain-containing proteins, syntenin, PICK1, GRIP, and PSD95, as interactors with the kainate receptor (KAR) subunits GluR5(2b,) GluR5(2c), and a kainate receptor sub... | autosomal recessive juvenile Parkinson disease 2 | Medium | convergence | {"qa_id":"medium_convergence_00994","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLG4 and SLC1A6 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'We identified four PDZ dom... | |
medium_convergence_00995 | Rhinovirus A and Human gammaherpesvirus 8 both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 1.206 and an adjusted p-value of 0.03413. Which protein is encoded by this gene? | Protein Tob1 | Medium | convergence | {"qa_id":"medium_convergence_00995","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Human gammaherpesvirus 8 both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) ... | |
medium_convergence_00996 | SMAD2 and TEAD4 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'Functional assays demonstrated the positive impact of OTUD6A on the transcription of YAP-TEAD target genes.' Which protein is connected to that specific shared partner through the 'encodes'... | WW domain-containing transcription regulator protein 1 | Medium | convergence | {"qa_id":"medium_convergence_00996","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD2 and TEAD4 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'Functional assays demonstr... | |
medium_convergence_00997 | Both Influenza A virus and Dengue virus are associated with the downregulation of a specific gene. Experimental data for this gene reports a log2 fold change of approximately -1.07 and an adjusted p-value of 0.0022. Which protein is encoded by this gene? | Sideroflexin-3 | Medium | convergence | {"qa_id":"medium_convergence_00997","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Influenza A virus and Dengue virus are associated with the downregulation of a specific gene. Experimental data for this gene reports a log2 fold change... | |
medium_convergence_00998 | TOPBP1 and ESR1 share a common interacting partner. Evidence indicates that under conditions of glucose deprivation, this shared partner is activated and deacetylates TOPBP1, leading to the dissociation of the TOPBP1-Treslin complex and the inhibition of DNA replication. Which protein is encoded by this shared interact... | NAD-dependent protein deacetylase sirtuin-1 | Medium | convergence | {"qa_id":"medium_convergence_00998","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TOPBP1 and ESR1 share a common interacting partner. Evidence indicates that under conditions of glucose deprivation, this shared partner is activated and dea... | |
medium_convergence_00999 | Hepacivirus C and Dengue virus both upregulate a specific gene. Evidence for this gene shows a log2 fold change of approximately 3.17 and an adjusted p-value of 0.01043. Which disease is associated with this gene as a biomarker? | bipolar disorder | Medium | convergence | {"qa_id":"medium_convergence_00999","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hepacivirus C and Dengue virus both upregulate a specific gene. Evidence for this gene shows a log2 fold change of approximately 3.17 and an adjusted p-value... | |
medium_convergence_01000 | Somatotropin and Cyclosporine both interact with a specific drug. Evidence regarding this drug notes that pharmacokinetic parameters changed, albeit not significantly, before and after antiretroviral therapy (ART), specifically citing changes in cyclosporine A levels (Cmax -64%, Cmin +14%, AUC -47%; n = 2). Which disea... | HIV infectious disease | Medium | convergence | {"qa_id":"medium_convergence_01000","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Somatotropin and Cyclosporine both interact with a specific drug. Evidence regarding this drug notes that pharmacokinetic parameters changed, albeit not sign... | |
medium_convergence_01001 | RIMS1 and SLC18A2 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'We show that the active zone components Munc13-1, an essential vesicle priming protein, and RIM1, a Rab3 effector with a putative role in vesicle tethering, interact functionally.' Which prote... | Protein unc-13 homolog B | Medium | convergence | {"qa_id":"medium_convergence_01001","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RIMS1 and SLC18A2 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'We show that the active zone ... | |
medium_convergence_01002 | Rhinovirus A and Human gammaherpesvirus 8 both upregulate a specific gene. In cytotoxic T-lymphocytes, evidence for this gene shows a log2 fold change of approximately 1.069 and an adjusted p-value of 0.003396. Which protein is encoded by this gene? | RING finger and SPRY domain-containing protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01002","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Human gammaherpesvirus 8 both upregulate a specific gene. In cytotoxic T-lymphocytes, evidence for this gene shows a log2 fold change of app... | |
medium_convergence_01003 | PARP1 and MSH6 both interact with a specific shared protein. Experimental evidence indicates that thirty minutes after exposing cells to ionizing radiation, the CaM and FACT complexes dissociated, whereas PARP1 and DEAH box polypeptide 30 isoform 1 interacted with this shared protein. Which protein is encoded by the ge... | Histone H2AX | Medium | convergence | {"qa_id":"medium_convergence_01003","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and MSH6 both interact with a specific shared protein. Experimental evidence indicates that thirty minutes after exposing cells to ionizing radiation, ... | |
medium_convergence_01004 | CSNK2A1 and SIRT1 both interact with a shared protein. Evidence indicates that the interaction between Nuclear CK2 and TAp73, confirmed by co-immunoprecipitation, was attenuated by a CK2 inhibitor or by a T27A point mutation at a predicted CK2 threonine phospho-acceptor site on TAp73. Which disease is causally linked t... | aneuploidy | Medium | convergence | {"qa_id":"medium_convergence_01004","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2A1 and SIRT1 both interact with a shared protein. Evidence indicates that the interaction between Nuclear CK2 and TAp73, confirmed by co-immunoprecipita... | |
medium_convergence_01005 | MDM2 and PLK1 both interact with a specific shared protein. Evidence regarding this shared protein states: 'We show that Rb, this shared protein, and the C8 subunit of the 20S proteasome interact in vitro and in vivo and that this shared protein promotes Rb-C8 interaction.' Which protein is encoded by this shared entit... | Proteasome subunit alpha type-7 | Medium | convergence | {"qa_id":"medium_convergence_01005","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MDM2 and PLK1 both interact with a specific shared protein. Evidence regarding this shared protein states: 'We show that Rb, this shared protein, and the C8 ... | |
medium_convergence_01006 | ESR1 and THRA both interact with a shared protein. Evidence regarding this shared protein states: 'Studies with extracts from TRAP220(-/-) fibroblasts reveal that these interactions depend on TRAP220, a TRAP/Mediator subunit previously shown to interact with ER and other nuclear receptors in a ligand-dependent manner.'... | Mediator of RNA polymerase II transcription subunit 24 | Medium | convergence | {"qa_id":"medium_convergence_01006","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and THRA both interact with a shared protein. Evidence regarding this shared protein states: 'Studies with extracts from TRAP220(-/-) fibroblasts reveal... | |
medium_convergence_01008 | Rhinovirus A and Zika virus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 1.297 and an adjusted p-value of approximately 0.0063. Which disease is therapeutically associated with this gene? | pulmonary fibrosis | Medium | convergence | {"qa_id":"medium_convergence_01008","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Zika virus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2... | |
medium_convergence_01009 | CHEK1 and PARP1 both interact with a specific gene. Evidence regarding one such shared partner states: 'We identified a novel interaction between this gene and checkpoint kinase CHK1 and showed that the defective damage response in cells deficient for this gene is at least in part due to altered CHK1 subcellular locali... | Ogden syndrome | Medium | convergence | {"qa_id":"medium_convergence_01009","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK1 and PARP1 both interact with a specific gene. Evidence regarding one such shared partner states: 'We identified a novel interaction between this gene a... | |
medium_convergence_01010 | MDM2 and TP53 share multiple interacting partners. One such shared partner is involved in a regulatory mechanism where cross-regulation critically depends on the physical interaction of this entity with MDM2 through the K170 residue of the shared partner. Which gene is connected to this specific shared entity via a 'bi... | PPARA | Medium | convergence | {"qa_id":"medium_convergence_01010","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MDM2 and TP53 share multiple interacting partners. One such shared partner is involved in a regulatory mechanism where cross-regulation critically depends on... | |
medium_convergence_01011 | Erythromycin and Morphine share a common drug interaction partner. Evidence indicates that the concomitant administration of VPA and this shared entity resulted in an increase in social interaction criteria during both chronic and withdrawal phases. Which disease is this shared entity indicated for? | bipolar disorder | Medium | convergence | {"qa_id":"medium_convergence_01011","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Erythromycin and Morphine share a common drug interaction partner. Evidence indicates that the concomitant administration of VPA and this shared entity resul... | |
medium_convergence_01012 | CTNNB1 and EP300 share multiple interacting partners. One such partner is described as a T lineage-enriched chromatin organizer and global regulator that interacts with beta-catenin and recruits it to its genomic binding sites. Which protein is encoded by the gene corresponding to this specific partner? | DNA-binding protein SATB1 | Medium | convergence | {"qa_id":"medium_convergence_01012","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and EP300 share multiple interacting partners. One such partner is described as a T lineage-enriched chromatin organizer and global regulator that int... | |
medium_convergence_01013 | ARAF and KRAS both interact with a shared protein partner. Evidence indicates that in yeast two-hybrid screening using a specific MAP2K family member as bait, A-Raf was identified as a novel interacting partner alongside c-Raf and KSR. Which protein is encoded by this shared partner? | Dual specificity mitogen-activated protein kinase kinase 2 | Medium | convergence | {"qa_id":"medium_convergence_01013","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARAF and KRAS both interact with a shared protein partner. Evidence indicates that in yeast two-hybrid screening using a specific MAP2K family member as bait... | |
medium_convergence_01014 | NEDD8 and CUL5 both interact with a specific shared protein. Evidence indicates that for this shared protein, the interaction with CUL5 is mediated specifically by residues Pro184 and Arg186, which are located in the C-terminal part of the SOCS box (referred to as the CUL5 box). Which protein is encoded by the gene cor... | Suppressor of cytokine signaling 2 | Medium | convergence | {"qa_id":"medium_convergence_01014","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NEDD8 and CUL5 both interact with a specific shared protein. Evidence indicates that for this shared protein, the interaction with CUL5 is mediated specifica... | |
medium_convergence_01015 | CCL11 and LAMTOR3 both interact with a specific protein kinase. Evidence regarding this shared partner states: 'In a two-hybrid screen with p14 as a bait, we identified the mitogen-activated protein kinase (MAPK) scaffolding protein MAPK/extracellular signal-regulated kinase (ERK) kinase (MEK) partner 1 (MP1) as an int... | Dual specificity mitogen-activated protein kinase kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_01015","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CCL11 and LAMTOR3 both interact with a specific protein kinase. Evidence regarding this shared partner states: 'In a two-hybrid screen with p14 as a bait, we... | |
medium_convergence_01017 | STRA13 and CENPS each interact with more than one shared protein partner. Biochemical evidence indicates that MHF1 and MHF2 assemble into a heterodimer that binds DNA and enhances the DNA branch migration activity of one of these shared partners. Which protein is encoded by the gene corresponding to this shared partner... | Fanconi anemia core complex-associated protein 100 | Medium | convergence | {"qa_id":"medium_convergence_01017","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STRA13 and CENPS each interact with more than one shared protein partner. Biochemical evidence indicates that MHF1 and MHF2 assemble into a heterodimer that ... | |
medium_convergence_01018 | IFNA2 and IFNA4 both interact with a common receptor. Evidence regarding one of these shared partners states: 'The 25 kDa, non-glycosylated [entity]-EC is a stable, fully active protein, which inhibits antiviral activity of IFNalpha2.' Which protein is encoded by this specific entity? | Interferon alpha/beta receptor 2 | Medium | convergence | {"qa_id":"medium_convergence_01018","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IFNA2 and IFNA4 both interact with a common receptor. Evidence regarding one of these shared partners states: 'The 25 kDa, non-glycosylated [entity]-EC is a ... | |
medium_convergence_01019 | Enterovirus A and Cardiovirus A both upregulate a specific gene. Evidence for this gene in rhabdomyosarcoma cells (from study GSE103308) reports a log2 fold change of approximately 2.116 and an adjusted p-value of 0.03423. Which cell type is this gene enriched in? | gamma-delta T cell | Medium | convergence | {"qa_id":"medium_convergence_01019","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Enterovirus A and Cardiovirus A both upregulate a specific gene. Evidence for this gene in rhabdomyosarcoma cells (from study GSE103308) reports a log2 fold ... | |
medium_convergence_01020 | Both Human alphaherpesvirus 3 and Pegivirus C are associated with the downregulation of a specific gene. Experimental data for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of approximately -1.101 and an adjusted p-value of 3.622e-05. Which protein is encoded by this gene? | BRI3-binding protein | Medium | convergence | {"qa_id":"medium_convergence_01020","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Pegivirus C are associated with the downregulation of a specific gene. Experimental data for this gene in a melanoma cell l... | |
medium_convergence_01021 | Both RB1 and RPA1 interact with a common protein partner. Evidence for one such partner states: 'We have used the yeast two-hybrid system to screen for cellular proteins which bind to the first 300 amino acids of p110RB.' Which disease is associated with this specific protein partner? | hearing loss, autosomal dominant 86 | Medium | convergence | {"qa_id":"medium_convergence_01021","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both RB1 and RPA1 interact with a common protein partner. Evidence for one such partner states: 'We have used the yeast two-hybrid system to screen for cellu... | |
medium_convergence_01022 | Both IKBKB and BCL10 share physical interactions with a common protein partner. Evidence regarding one such partner states: 'We show that [MAP3K7] physically interacts with NIK and with IKK2, and both XIAP or active [MAP3K7] can stimulate IKK2 kinase activity.' Which protein is encoded by the gene corresponding to this... | Mitogen-activated protein kinase kinase kinase 7 | Medium | convergence | {"qa_id":"medium_convergence_01022","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both IKBKB and BCL10 share physical interactions with a common protein partner. Evidence regarding one such partner states: 'We show that [MAP3K7] physically... | |
medium_convergence_01024 | Zaire ebolavirus and Zika virus both downregulate a specific gene. Experimental data from a retinal pigment epithelium cell line (study GSE100839) indicates that for one such shared target, the log2 fold change is -1.295 and the adjusted p-value is 0.001529. Which protein is encoded by this gene? | Guanine nucleotide-binding protein G(q) subunit alpha | Medium | convergence | {"qa_id":"medium_convergence_01024","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Zaire ebolavirus and Zika virus both downregulate a specific gene. Experimental data from a retinal pigment epithelium cell line (study GSE100839) indicates ... | |
medium_convergence_01025 | CDK5 and DNER are both involved in multiple shared biological processes. One of these shared processes is characterized by its normal association with neuronal activities such as migration, cortical layering, and synaptic plasticity. Which higher-level biological process is this specific shared process a part of? | generation of neurons | Medium | convergence | {"qa_id":"medium_convergence_01025","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK5 and DNER are both involved in multiple shared biological processes. One of these shared processes is characterized by its normal association with neuron... | |
medium_convergence_01026 | FANCC and FAAP100 both interact with a specific protein. Evidence regarding this protein states: 'The N terminus appears to stabilize the interaction with FANCA and FANCG and is essential for the binding of the FANCC/FANCE subcomplex.' Which disease is associated with this protein through genomic alterations? | Fanconi anemia | Medium | convergence | {"qa_id":"medium_convergence_01026","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCC and FAAP100 both interact with a specific protein. Evidence regarding this protein states: 'The N terminus appears to stabilize the interaction with FA... | |
medium_convergence_01027 | Vaccinia virus and Enterovirus A both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates that this gene has a log2 fold change of approximately -1.68 and an adjusted p-value of approximately 0.0032. Which protein is encoded by this gene? | Ras association domain-containing protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01027","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Enterovirus A both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates tha... | |
medium_convergence_01028 | Human alphaherpesvirus 1 and Human betaherpesvirus 5 both downregulate a specific gene. In a study using a monocytic leukemia cell line (GSE114966), this gene exhibited a log2 fold change of -1.406 and an adjusted p-value of 0.003552. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_01028","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human betaherpesvirus 5 both downregulate a specific gene. In a study using a monocytic leukemia cell line (GSE114966), this gen... | |
medium_convergence_01029 | WNT2 and WNT2B are both involved in a shared biological process. Evidence indicates that several Wnts were expressed in the lens, specifically including WNT2 and WNT2B in the anterior epithelium, alongside Wnt5a, Wnt5b, Wnt7a, and Wnt7b in differentiating lens fiber cells. Which biological process, connected to this en... | anatomical structure development | Medium | convergence | {"qa_id":"medium_convergence_01029","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"WNT2 and WNT2B are both involved in a shared biological process. Evidence indicates that several Wnts were expressed in the lens, specifically including WNT2... | |
medium_convergence_01030 | CRCP and GTF3C2 share multiple protein interaction partners. One such shared partner is characterized by evidence reporting novel interactions of hTFIIIC63 with hTFIIIC102, hTFIIIB90, and hRPC62, alongside hTFIIIC102-hTFIIIB90 and hTFIIIB90-hRPC39 interactions that parallel yeast models. Which protein is connected to t... | General transcription factor 3C polypeptide 3 | Medium | convergence | {"qa_id":"medium_convergence_01030","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRCP and GTF3C2 share multiple protein interaction partners. One such shared partner is characterized by evidence reporting novel interactions of hTFIIIC63 w... | |
medium_convergence_01031 | CREBBP and DHX9 share a common interaction partner. Evidence regarding one such partner states: 'In this study, we found that [the shared partner] associates with a transcriptional co-activator CREB-binding protein (CBP) and the hypophosphorylated RNA polymerase II, which are included preferentially in the transcriptio... | RNA-binding protein EWS | Medium | convergence | {"qa_id":"medium_convergence_01031","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and DHX9 share a common interaction partner. Evidence regarding one such partner states: 'In this study, we found that [the shared partner] associates... | |
medium_convergence_01033 | Enterovirus A and Zaire ebolavirus both downregulate a specific gene. Experimental data from rhabdomyosarcoma cells (study GSE103308) indicate that this gene exhibits a log2 fold change of approximately -1.25 and an adjusted p-value of 0.00052. Which biological process is this gene involved in? | negative regulation of membrane protein ectodomain proteolysis | Medium | convergence | {"qa_id":"medium_convergence_01033","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Enterovirus A and Zaire ebolavirus both downregulate a specific gene. Experimental data from rhabdomyosarcoma cells (study GSE103308) indicate that this gene... | |
medium_convergence_01034 | LAT and PLCG1 share multiple binding partners. One shared partner is described by the following evidence: 'We observed association between the PLCgamma1-SH3 domain and the human Ras guanine nucleotide exchange factor son-of-sevenless-2 (hSos2) through a proline-rich domain interaction.' Which protein is connected to th... | Son of sevenless homolog 2 | Medium | convergence | {"qa_id":"medium_convergence_01034","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LAT and PLCG1 share multiple binding partners. One shared partner is described by the following evidence: 'We observed association between the PLCgamma1-SH3 ... | |
medium_convergence_01035 | CREBBP and MED1 both interact with a specific shared protein. Evidence regarding this shared entity states: 'We now report that [the shared protein] strongly interacts with transcriptional coactivators, CBP, p300, and PBP but not with SRC-1 and PGC-1alpha under in vitro and in vivo conditions.' Which protein is encoded... | Trimethylguanosine synthase | Medium | convergence | {"qa_id":"medium_convergence_01035","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and MED1 both interact with a specific shared protein. Evidence regarding this shared entity states: 'We now report that [the shared protein] strongly... | |
medium_convergence_01036 | CNOT1 and EIF3A both interact with a shared protein. Evidence indicates that activating mTOR signaling with insulin increases the amount of this protein bound to eIF3 by as much as five-fold. Which disease is associated with this shared protein? | Parkinson disease 18, autosomal dominant, susceptibility to | Medium | convergence | {"qa_id":"medium_convergence_01036","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CNOT1 and EIF3A both interact with a shared protein. Evidence indicates that activating mTOR signaling with insulin increases the amount of this protein boun... | |
medium_convergence_01037 | BIRC2 and PEX14 share multiple binding partners. One such shared partner is implicated in a mechanism where the cIAP1 RING domain interacts with a ubiquitin-conjugating enzyme-Ub complex, promoting a closed conformation that primes the thioester bond for ubiquitin transfer. Which protein encodes this specific shared bi... | Ubiquitin-conjugating enzyme E2 D2 | Medium | convergence | {"qa_id":"medium_convergence_01037","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC2 and PEX14 share multiple binding partners. One such shared partner is implicated in a mechanism where the cIAP1 RING domain interacts with a ubiquitin-... | |
medium_convergence_01038 | Insulin lispro and Metformin both interact with a specific drug. Evidence indicates that this drug shares similar antihypertensive effects with Metformin and demonstrates good synergy in the treatment of essential hypertension with hyperinsulinemia. Which disease is this drug indicated for? | congestive heart failure | Medium | convergence | {"qa_id":"medium_convergence_01038","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Insulin lispro and Metformin both interact with a specific drug. Evidence indicates that this drug shares similar antihypertensive effects with Metformin and... | |
medium_convergence_01040 | CDC37 and ESR1 share multiple interacting partners. One such shared partner is characterized by direct interaction with the ligand binding domain of ER and recruitment to the proximal promoter regions of ER target genes upon gene induction. Which cell type is this specific shared partner enriched in? | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_01040","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDC37 and ESR1 share multiple interacting partners. One such shared partner is characterized by direct interaction with the ligand binding domain of ER and r... | |
medium_convergence_01041 | EMD and LMNA share interaction partners. One such partner is identified in a study using a mass spectrometry-based approach, which reports that lamins and lamin-binding proteins, including retinoblastoma protein (pRb), lamina-associated polypeptide 2α (LAP2α), and emerin, interact with this specific entity. Which cellu... | cytoplasm | Medium | convergence | {"qa_id":"medium_convergence_01041","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EMD and LMNA share interaction partners. One such partner is identified in a study using a mass spectrometry-based approach, which reports that lamins and la... | |
medium_convergence_01042 | Both ABL1 and MSH2 interact with a common protein partner. Experimental evidence indicates that c-Abl is bound to chromatin and exhibits enhanced interaction with Atm and this shared partner in response to DNA damage. Which protein is encoded by this shared partner? | Serine/threonine-protein kinase ATR | Medium | convergence | {"qa_id":"medium_convergence_01042","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both ABL1 and MSH2 interact with a common protein partner. Experimental evidence indicates that c-Abl is bound to chromatin and exhibits enhanced interaction... | |
medium_convergence_01043 | UBAP1 and UBB each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here we show that ubiquitin associated protein 1 (UBAP1), a subunit of human ESCRT-I, coassembles in a stable 1:1:1:1 complex with Vps23/TSG101, this shared protein, and VPS37.' Which protein is encoded by thi... | Vacuolar protein sorting-associated protein 28 homolog | Medium | convergence | {"qa_id":"medium_convergence_01043","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UBAP1 and UBB each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Here we show that ubiquitin associated protein... | |
medium_convergence_01044 | Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Experimental data from a study on lung fibroblast cell lines (GSE120891) indicates that this gene exhibits a log2 fold change of approximately -1.69 and an adjusted p-value of... | Corrinoid adenosyltransferase MMAB | Medium | convergence | {"qa_id":"medium_convergence_01044","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Experimental... | |
medium_convergence_01045 | COPE and COPB1 both interact with a shared protein partner. Evidence regarding this partner states: 'Here we report the ubiquitous expression of two novel isotypes of coatomer subunits gamma- and zeta-COP that are incorporated into coatomer, and show that three isotypes exist of the complex defined by the subunit combi... | Coatomer subunit gamma-2 | Medium | convergence | {"qa_id":"medium_convergence_01045","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPE and COPB1 both interact with a shared protein partner. Evidence regarding this partner states: 'Here we report the ubiquitous expression of two novel is... | |
medium_convergence_01046 | EGF and EGFR both interact with a specific protein. Experimental evidence indicates that this protein interacts with ubiquitinated EGFR and that functional UIMs are essential for this complex formation. Which disease is associated with this protein? | colon carcinoma | Medium | convergence | {"qa_id":"medium_convergence_01046","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGF and EGFR both interact with a specific protein. Experimental evidence indicates that this protein interacts with ubiquitinated EGFR and that functional U... | |
medium_convergence_01047 | KCTD7 and PRKN (PARK2) both interact with a specific calpain gene. Evidence indicates that the protein product of this gene is ubiquitinated at lysine residues K280 and K674 by a complex involving KCTD7, Cullin-3, and Rbx1. Which protein is encoded by this gene? | Calpain-2 catalytic subunit | Medium | convergence | {"qa_id":"medium_convergence_01047","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KCTD7 and PRKN (PARK2) both interact with a specific calpain gene. Evidence indicates that the protein product of this gene is ubiquitinated at lysine residu... | |
medium_convergence_01048 | CASP2 and CASP10 each share a binding partner. Evidence concerning one shared entity reports: 'Fluorescent resonance energy transfer analysis indicates that the death-effector domains of caspase-8 and -10 both interact with the death-effector domain of this adapter molecule.' Which disease is connected to that entity t... | hypersensitivity reaction disease | Medium | convergence | {"qa_id":"medium_convergence_01048","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CASP2 and CASP10 each share a binding partner. Evidence concerning one shared entity reports: 'Fluorescent resonance energy transfer analysis indicates that ... | |
medium_convergence_01049 | LIN9 and LIN52 both interact with a shared protein complex component. Evidence regarding this component states: 'Using an integrated approach combining proteomics, genomics, and bioinformatic analyses, we identified a complex termed DP, RB-like, E2F, and MuvB (DREAM) that contains mammalian homologs of synMuvB proteins... | hepatocellular carcinoma | Medium | convergence | {"qa_id":"medium_convergence_01049","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LIN9 and LIN52 both interact with a shared protein complex component. Evidence regarding this component states: 'Using an integrated approach combining prote... | |
medium_convergence_01050 | NOX1 and NOX3 share a common binding partner. Evidence indicates that phosphorylation of this shared entity on Ser-282 and Ser-172 decreases its binding to NOX1 and Rac1. Which disease is associated with this entity? | hyperplasia | Medium | convergence | {"qa_id":"medium_convergence_01050","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NOX1 and NOX3 share a common binding partner. Evidence indicates that phosphorylation of this shared entity on Ser-282 and Ser-172 decreases its binding to N... | |
medium_convergence_01051 | EME1 and CENPS both interact with a shared protein. Biochemical evidence indicates that MHF1 and MHF2 form a heterodimer that binds DNA and enhances the DNA branch migration activity of this shared protein. Which protein is encoded by the gene corresponding to this shared entity? | Fanconi anemia core complex-associated protein 100 | Medium | convergence | {"qa_id":"medium_convergence_01051","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EME1 and CENPS both interact with a shared protein. Biochemical evidence indicates that MHF1 and MHF2 form a heterodimer that binds DNA and enhances the DNA ... | |
medium_convergence_01052 | HOOK2 and HOOK1 each interact with more than one shared gene product. Evidence concerning one of these shared entities reports that Hook proteins were found to form homo- and heterodimers. Which protein is encoded by that entity? | Protein Hook homolog 3 | Medium | convergence | {"qa_id":"medium_convergence_01052","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HOOK2 and HOOK1 each interact with more than one shared gene product. Evidence concerning one of these shared entities reports that Hook proteins were found ... | |
medium_convergence_01053 | COMMD1 and CUL1 each interact with more than one shared protein. Evidence concerning one such shared entity states: 'All FBA proteins co-precipitated components of the canonical SCF complex (Skp1, Cullin1, and Rbx1), yet this entity bound very little Cullin1, suggesting that this entity may exist primarily as a heterod... | SCF ubiquitin ligase complex | Medium | convergence | {"qa_id":"medium_convergence_01053","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COMMD1 and CUL1 each interact with more than one shared protein. Evidence concerning one such shared entity states: 'All FBA proteins co-precipitated compone... | |
medium_convergence_01054 | CBFB and LDB1 both interact with a specific LIM-domain protein. Evidence indicates that this protein and LMO4 interact with the ubiquitous nuclear adaptor protein LDB1 (also known as NLI or CLIM2), which associates with the LIM domains of LMO and LIM homeodomain proteins via its LIM interaction domain (LDB1-LID). Which... | Rhombotin-2 | Medium | convergence | {"qa_id":"medium_convergence_01054","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBFB and LDB1 both interact with a specific LIM-domain protein. Evidence indicates that this protein and LMO4 interact with the ubiquitous nuclear adaptor pr... | |
medium_convergence_01055 | BICD2 and RAN share multiple interacting partners. One of these shared partners is phosphorylated by a NIMA-related kinase in vitro, and the endogenous proteins associate in vivo. Which disease is associated with this specific shared partner as a biomarker? | melanoma | Medium | convergence | {"qa_id":"medium_convergence_01055","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BICD2 and RAN share multiple interacting partners. One of these shared partners is phosphorylated by a NIMA-related kinase in vitro, and the endogenous prote... | |
medium_convergence_01056 | ADRM1 and PSMD1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners indicates that hRpn13 interacts with a base subunit Rpn2 via its amino-terminus. Which protein is encoded by the gene corresponding to that shared partner? | 26S proteasome non-ATPase regulatory subunit 2 | Medium | convergence | {"qa_id":"medium_convergence_01056","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ADRM1 and PSMD1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners indicates that hRpn13 interacts wit... | |
medium_convergence_01057 | CYLD and RNF31 both interact with a shared protein. Evidence regarding one such shared partner states: 'Here, we show that Optineurin (Optn) dampens the antiviral innate immune response by targeting the deubiquitinating enzyme CYLD to [the shared protein] in order to inhibit its enzymatic activity.' Which disease is as... | myelofibrosis | Medium | convergence | {"qa_id":"medium_convergence_01057","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CYLD and RNF31 both interact with a shared protein. Evidence regarding one such shared partner states: 'Here, we show that Optineurin (Optn) dampens the anti... | |
medium_convergence_01058 | Vaccinia virus and Rhinovirus A both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates that this gene exhibits a log2 fold change of approximately -2.45 and an adjusted p-value of 0.0167. Which protein does this gene product bind to? | SERPINB13 | Medium | convergence | {"qa_id":"medium_convergence_01058","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Rhinovirus A both downregulate a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates that... | |
medium_convergence_01060 | AJUBA and EED both interact with a shared protein. Evidence regarding this shared protein states: 'Here we describe the specific in vivo binding of Eed to Enx1 and Enx2, two mammalian homologs of the essential Drosophila Pc-G gene Enhancer-of-zeste [E(z)].' Which protein is encoded by the gene corresponding to this sha... | Histone-lysine N-methyltransferase EZH2 | Medium | convergence | {"qa_id":"medium_convergence_01060","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AJUBA and EED both interact with a shared protein. Evidence regarding this shared protein states: 'Here we describe the specific in vivo binding of Eed to En... | |
medium_convergence_01061 | TRIM28 and BRD4 share multiple interacting partners. One such shared partner is supported by evidence stating: 'Coimmunoprecipitation experiments showed that endogenous and transfected BRD4 interacts with replication factor C (RFC), the conserved five-subunit complex essential for DNA replication.' Which disease is ass... | Morimoto-Ryu-Malicdan neuromuscular syndrome | Medium | convergence | {"qa_id":"medium_convergence_01061","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and BRD4 share multiple interacting partners. One such shared partner is supported by evidence stating: 'Coimmunoprecipitation experiments showed that... | |
medium_convergence_01062 | PDCD6IP and TSG101 share common interaction partners. One such partner is described as an accessory protein containing an arrestin domain, which localizes to the plasma membrane and drives budding through a specific interaction with a tetrapeptide PSAP motif. Which cell type is enriched for this specific protein? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_01062","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PDCD6IP and TSG101 share common interaction partners. One such partner is described as an accessory protein containing an arrestin domain, which localizes to... | |
medium_convergence_01063 | E2F3 and RB1 both interact with a specific protein. Evidence indicates that Rb associates with this protein and HP1 in vivo via its pocket domain. Which protein is encoded by the gene corresponding to this interacting partner? | Histone-lysine N-methyltransferase SUV39H1 | Medium | convergence | {"qa_id":"medium_convergence_01063","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"E2F3 and RB1 both interact with a specific protein. Evidence indicates that Rb associates with this protein and HP1 in vivo via its pocket domain. Which prot... | |
medium_convergence_01064 | Dengue virus and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold change of approximately -1.29 and an adjusted p-value of 0.0157. Which protein is encoded by the gene associated with these specific statistical values? | Dynein axonemal assembly factor 9 | Medium | convergence | {"qa_id":"medium_convergence_01064","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold... | |
medium_convergence_01065 | LTA and LTB both interact with a specific receptor. Evidence indicates that both TNF and LT bind with higher affinity to the p80 receptor than to the p60 receptor. Which protein is encoded by the gene corresponding to this p80 receptor? | Tumor necrosis factor receptor superfamily member 1B | Medium | convergence | {"qa_id":"medium_convergence_01065","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LTA and LTB both interact with a specific receptor. Evidence indicates that both TNF and LT bind with higher affinity to the p80 receptor than to the p60 rec... | |
medium_convergence_01066 | Both Human alphaherpesvirus 3 and Zika virus are reported to downregulate the expression of a specific gene. Experimental data from a melanoma cell line (study GSE136586) indicates that this gene exhibits a log2 fold change of approximately -1.278 and an adjusted p-value of 6.018e-07. Which protein is encoded by this g... | Ubiquitin-associated and SH3 domain-containing protein B | Medium | convergence | {"qa_id":"medium_convergence_01066","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Zika virus are reported to downregulate the expression of a specific gene. Experimental data from a melanoma cell line (stu... | |
medium_convergence_01067 | COMMD1 and CUL4A both interact with a shared protein. Evidence indicates that this shared protein is a component of a DDB1-CUL4-ROC1 (CRL4) E3 ligase. Which biological process is this protein involved in? | negative regulation of adipose tissue development | Medium | convergence | {"qa_id":"medium_convergence_01067","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COMMD1 and CUL4A both interact with a shared protein. Evidence indicates that this shared protein is a component of a DDB1-CUL4-ROC1 (CRL4) E3 ligase. Which ... | |
medium_convergence_01068 | Both Measles morbillivirus and Influenza A virus are known to downregulate a specific shared gene. Experimental data for this gene reports a log2 fold change of -1.364 and an adjusted p-value of 0.03141. Which disease is causally linked to this gene? | purpura | Medium | convergence | {"qa_id":"medium_convergence_01068","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Influenza A virus are known to downregulate a specific shared gene. Experimental data for this gene reports a log2 fold change... | |
medium_convergence_01070 | Hepacivirus C and Dengue virus both upregulate a specific gene. Experimental evidence for this gene shows a log2 fold change of 1.279 and an adjusted p-value of 0.0001895. Which protein does this gene product interact with? | APP | Medium | convergence | {"qa_id":"medium_convergence_01070","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hepacivirus C and Dengue virus both upregulate a specific gene. Experimental evidence for this gene shows a log2 fold change of 1.279 and an adjusted p-value... | |
medium_convergence_01071 | EGLN3 and CREBBP both interact with a specific protein. Evidence indicates that PHD3 (encoded by EGLN3) associates with the protein encoded by IKBKB but does not target it for destruction; instead, PHD3 blocks the interaction between the protein encoded by IKBKB and Hsp90, which is required for the phosphorylation of t... | Inhibitor of nuclear factor kappa-B kinase subunit beta | Medium | convergence | {"qa_id":"medium_convergence_01071","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGLN3 and CREBBP both interact with a specific protein. Evidence indicates that PHD3 (encoded by EGLN3) associates with the protein encoded by IKBKB but does... | |
medium_convergence_01072 | Human alphaherpesvirus 1 and Rhinovirus A both upregulate a specific gene. Evidence for this gene in a monocytic leukemia cell line reports a log2 fold change of approximately 1.133 and an adjusted p-value of 0.004848. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_01072","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Rhinovirus A both upregulate a specific gene. Evidence for this gene in a monocytic leukemia cell line reports a log2 fold chang... | |
medium_convergence_01073 | GNA11 and GNAI1 each share a binding partner. Evidence concerning one such shared partner indicates that Galphai1, Galphai3, and Galphao interacted strongly with a specific RGS protein, whereas Galphai2 interacted weakly and Galphas did not interact at all. Which protein is connected to that shared partner through the ... | Regulator of G-protein signaling 19 | Medium | convergence | {"qa_id":"medium_convergence_01073","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNA11 and GNAI1 each share a binding partner. Evidence concerning one such shared partner indicates that Galphai1, Galphai3, and Galphao interacted strongly ... | |
medium_convergence_01074 | BIRC2 and BIRC3 both interact with a specific protein. Experimental evidence indicates that viral infection leads to the recruitment of cIAP1 and cIAP2 to this protein, alongside TRAF6 and VISA. Which protein is encoded by the gene corresponding to this interaction partner? | TNF receptor-associated factor 3 | Medium | convergence | {"qa_id":"medium_convergence_01074","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC2 and BIRC3 both interact with a specific protein. Experimental evidence indicates that viral infection leads to the recruitment of cIAP1 and cIAP2 to th... | |
medium_convergence_01075 | PLK1 and TP53 share multiple interacting partners. One such partner is supported by evidence stating: 'Here we report that the hCdc14A and hCdc14B proteins interact with the tumor suppressor protein p53 both in vitro and in vivo.' Which protein is encoded by the entity mentioned in this evidence that interacts with bot... | Dual specificity protein phosphatase CDC14A | Medium | convergence | {"qa_id":"medium_convergence_01075","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PLK1 and TP53 share multiple interacting partners. One such partner is supported by evidence stating: 'Here we report that the hCdc14A and hCdc14B proteins i... | |
medium_convergence_01076 | Both the regulation of mitochondrial fusion and the regulation of mitochondrial fission are subtypes of a shared biological process. Evidence regarding one of these shared processes states: 'Any process that modulates the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single co... | mitochondrion organization | Medium | convergence | {"qa_id":"medium_convergence_01076","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both the regulation of mitochondrial fusion and the regulation of mitochondrial fission are subtypes of a shared biological process. Evidence regarding one o... | |
medium_convergence_01077 | DYNLL1 and BECN1 share multiple binding partners. One shared partner is a protein whose depletion leads to Nedd4-mediated proteasomal degradation of Beclin 1 via Lys11-linked polyubiquitin chains. Which protein is encoded by the gene corresponding to this shared partner? | Phosphatidylinositol 3-kinase catalytic subunit type 3 | Medium | convergence | {"qa_id":"medium_convergence_01077","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DYNLL1 and BECN1 share multiple binding partners. One shared partner is a protein whose depletion leads to Nedd4-mediated proteasomal degradation of Beclin 1... | |
medium_convergence_01078 | Human alphaherpesvirus 1 and Human betaherpesvirus 5 both downregulate a specific gene. In a study using a monocytic leukemia cell line (GSE114966), this gene exhibited a log2 fold change of -1.378 and an adjusted p-value of 0.03816. What molecular function is enabled by this gene? | protein binding | Medium | convergence | {"qa_id":"medium_convergence_01078","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human betaherpesvirus 5 both downregulate a specific gene. In a study using a monocytic leukemia cell line (GSE114966), this gen... | |
medium_convergence_01080 | HDAC5 and SMAD2 both interact with a common protein. Evidence regarding this shared partner states: 'We found that HDAC5 was able to interact in vivo and in vitro with this protein, a MADS box transcription factor, and to strongly inhibit its transcriptional activity.' Which protein is encoded by this shared partner? | Myocyte-specific enhancer factor 2A | Medium | convergence | {"qa_id":"medium_convergence_01080","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC5 and SMAD2 both interact with a common protein. Evidence regarding this shared partner states: 'We found that HDAC5 was able to interact in vivo and in ... | |
medium_convergence_01081 | Human alphaherpesvirus 1 and Rift Valley fever phlebovirus both upregulate a specific gene. Experimental data for this gene reports a log2 fold change of approximately 2.74 and an adjusted p-value of approximately 0.0069. In which cell type is this gene enriched? | regulatory T cell | Medium | convergence | {"qa_id":"medium_convergence_01081","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Rift Valley fever phlebovirus both upregulate a specific gene. Experimental data for this gene reports a log2 fold change of app... | |
medium_convergence_01082 | VPS39 and VPS11 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Here, we report that a Beclin1-binding autophagic tumour suppressor, this entity, interacts with the class C Vps complex, a key component of the endosomal fusion machinery.' Which protein is encoded by ... | UV radiation resistance-associated gene protein | Medium | convergence | {"qa_id":"medium_convergence_01082","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"VPS39 and VPS11 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Here, we report that a Beclin1-binding ... | |
medium_convergence_01083 | TMOD1 and TNNC1 both interact with a shared protein partner. Contextual evidence specifies that Cardiac troponin I (cTnI) is the inhibitory component of the troponin complex and that its interaction with cardiac troponin C (cTnC) is critical for transmitting the Ca(2+) signal during heart muscle contraction. Which gene... | Troponin I, slow skeletal muscle | Medium | convergence | {"qa_id":"medium_convergence_01083","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TMOD1 and TNNC1 both interact with a shared protein partner. Contextual evidence specifies that Cardiac troponin I (cTnI) is the inhibitory component of the ... | |
medium_convergence_01084 | Dengue virus and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold change of approximately -1.33 and an adjusted p-value of 0.027. Which protein does this gene product interact with? | SFXN1 | Medium | convergence | {"qa_id":"medium_convergence_01084","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) reports a log2 fold... | |
medium_convergence_01085 | CHUK and IKBKG both interact with a shared protein. Evidence indicates that knockdown of TRIM14 disrupts the association between NF-κB essential modulator and this shared protein, thereby attenuating the antiviral response. Which protein is encoded by this shared entity? | Mitochondrial antiviral-signaling protein | Medium | convergence | {"qa_id":"medium_convergence_01085","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHUK and IKBKG both interact with a shared protein. Evidence indicates that knockdown of TRIM14 disrupts the association between NF-κB essential modulator an... | |
medium_convergence_01086 | Human alphaherpesvirus 1 and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) shows a log2 fold change of approximately -1.79 and an adjusted p-value of 0.0113. Which disease is associated with genomic alterations in this gene... | dental fluorosis | Medium | convergence | {"qa_id":"medium_convergence_01086","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human betaherpesvirus 5 both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (st... | |
medium_convergence_01088 | Both Measles morbillivirus and Cardiovirus A are known to upregulate a specific gene. Experimental data for this gene from study GSE131840 reports a log2 fold change of approximately 3.295 and an adjusted p-value of 0.001521. Which disease is associated with this gene as a biomarker? | Hodgkins lymphoma | Medium | convergence | {"qa_id":"medium_convergence_01088","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Cardiovirus A are known to upregulate a specific gene. Experimental data for this gene from study GSE131840 reports a log2 fol... | |
medium_convergence_01089 | AXIN1 and AXIN2 both interact with a specific protein. Evidence indicates that PAGE4 acts as a substrate decoy that hijacks binding sites on this protein to prevent the PARylation and degradation of AXIN1. Which protein is encoded by the gene corresponding to this interacting partner? | Poly [ADP-ribose] polymerase tankyrase-1 | Medium | convergence | {"qa_id":"medium_convergence_01089","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AXIN1 and AXIN2 both interact with a specific protein. Evidence indicates that PAGE4 acts as a substrate decoy that hijacks binding sites on this protein to ... | |
medium_convergence_01090 | Both Human orthopneumovirus and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 1.362 and an adjusted p-value of 0.04114. Which cell type is... | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_01090","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human orthopneumovirus and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data for t... | |
medium_convergence_01091 | YAP1 and COPS5 both interact with a shared protein. Evidence regarding this shared protein states: 'We confirmed a direct interaction of Jab1 with LMP-1 using recombinantly expressed wild-type and mutant proteins in slot-blot-binding assays.' Which protein is encoded by this shared entity? | PDZ and LIM domain protein 7 | Medium | convergence | {"qa_id":"medium_convergence_01091","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and COPS5 both interact with a shared protein. Evidence regarding this shared protein states: 'We confirmed a direct interaction of Jab1 with LMP-1 usin... | |
medium_convergence_01092 | CCL5 and CCL15 both interact with a specific G protein-coupled receptor. Evidence indicates that this receptor, cloned from human eosinophils, binds eotaxin, MCP-3, and RANTES with dissociation constants of 0.1, 2.7, and 3.1 nM, respectively. Which disease is associated with this receptor as a biomarker? | pulmonary fibrosis | Medium | convergence | {"qa_id":"medium_convergence_01092","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CCL5 and CCL15 both interact with a specific G protein-coupled receptor. Evidence indicates that this receptor, cloned from human eosinophils, binds eotaxin,... | |
medium_convergence_01093 | RCHY1 and TP53 both interact with a shared protein. Evidence regarding one such shared entity states: 'We found that Pirh2 (p53-induced RING-H2) E3 ubiquitin ligase physically interacts with [the protein encoded by the shared gene] and targets [the protein encoded by the shared gene] for polyubiquitination and subseque... | Tumor protein 63 | Medium | convergence | {"qa_id":"medium_convergence_01093","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RCHY1 and TP53 both interact with a shared protein. Evidence regarding one such shared entity states: 'We found that Pirh2 (p53-induced RING-H2) E3 ubiquitin... |
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