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medium_convergence_00866 | CHEK2 and SGO1 share multiple interacting partners. One such partner was identified in a yeast two-hybrid screen as the B' regulatory subunit of protein phosphatase PP2A that associates with Chk2. Which disease is associated with this specific PP2A regulatory subunit? | melanoma | Medium | convergence | {"qa_id":"medium_convergence_00866","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHEK2 and SGO1 share multiple interacting partners. One such partner was identified in a yeast two-hybrid screen as the B' regulatory subunit of protein phos... | |
medium_convergence_00868 | HUWE1 and AR share multiple interacting partners. One such shared partner is described in evidence stating: 'We have recently characterized a protein as an androgen receptor (AR)-interacting protein (ARIP) that belongs to the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] ... | E3 SUMO-protein ligase PIAS2 | Medium | convergence | {"qa_id":"medium_convergence_00868","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HUWE1 and AR share multiple interacting partners. One such shared partner is described in evidence stating: 'We have recently characterized a protein as an a... | |
medium_convergence_00869 | GRAP and GRB10 both interact with a specific receptor tyrosine kinase. Experimental evidence indicates that the SH2 domain of Grb10 interacts with the cytoplasmic tail of this receptor, as demonstrated by a yeast two-hybrid screen using the receptor's cytoplasmic tail fused to LexA as bait and a mouse embryo cDNA libra... | Mast/stem cell growth factor receptor Kit | Medium | convergence | {"qa_id":"medium_convergence_00869","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRAP and GRB10 both interact with a specific receptor tyrosine kinase. Experimental evidence indicates that the SH2 domain of Grb10 interacts with the cytopl... | |
medium_convergence_00870 | CENPN and HIST1H4A share multiple binding partners. One of these shared partners is described as binding at a stoichiometric ratio to the CENP-A/H4 tetramer but not to the H3/H4 tetramer. Which disease is associated with this specific shared partner? | astrocytoma (excluding glioblastoma) | Medium | convergence | {"qa_id":"medium_convergence_00870","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPN and HIST1H4A share multiple binding partners. One of these shared partners is described as binding at a stoichiometric ratio to the CENP-A/H4 tetramer ... | |
medium_convergence_00871 | CRK and ABL1 share common interaction partners. One such shared partner is described by evidence stating: 'We have identified a kinase activity, which binds to the first Crk SH3 domain and phosphorylates c-Crk on tyrosine 221 (Y221), as c-Abl.' Which protein is encoded by this shared interaction partner? | Tyrosine-protein kinase ABL2 | Medium | convergence | {"qa_id":"medium_convergence_00871","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRK and ABL1 share common interaction partners. One such shared partner is described by evidence stating: 'We have identified a kinase activity, which binds ... | |
medium_convergence_00873 | Human betaherpesvirus 5 and Pegivirus C both upregulate a specific gene. Experimental data for this gene in a retinal pigment epithelium cell line (study GSE120891) shows a log2 fold change of approximately 1.64 and an adjusted p-value of 0.0045. Which disease is associated with this gene via genomic alterations? | B-cell chronic lymphocytic leukemia | Medium | convergence | {"qa_id":"medium_convergence_00873","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Pegivirus C both upregulate a specific gene. Experimental data for this gene in a retinal pigment epithelium cell line (study GSE... | |
medium_convergence_00875 | MAPK8IP2 and HSP90AA1 share multiple interacting partners. One such partner is described by the evidence: 'We show that endogenous [MAP3K11] complexes with Hsp90 and p50(cdc37).' Which disease is associated with this specific interacting partner? | Aarskog-Scott syndrome, X-linked | Medium | convergence | {"qa_id":"medium_convergence_00875","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAPK8IP2 and HSP90AA1 share multiple interacting partners. One such partner is described by the evidence: 'We show that endogenous [MAP3K11] complexes with H... | |
medium_convergence_00876 | Measles morbillivirus and Rift Valley fever phlebovirus both upregulate a specific gene. Experimental data for this gene shows a log2 fold change of approximately 3.09 and an adjusted p-value of 0.007492. Which disease is associated with this gene? | epilepsy, familial adult myoclonic, 7 | Medium | convergence | {"qa_id":"medium_convergence_00876","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Measles morbillivirus and Rift Valley fever phlebovirus both upregulate a specific gene. Experimental data for this gene shows a log2 fold change of approxim... | |
medium_convergence_00877 | FKBP4 and HSP90AA1 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'The adaptor protein encoded by the gene corresponding to that shared partner mediates the association of the molecular chaperones Hsp70 and Hsp90.' Which protein is encoded by the gene corres... | Stress-induced-phosphoprotein 1 | Medium | convergence | {"qa_id":"medium_convergence_00877","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FKBP4 and HSP90AA1 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'The adaptor protein encoded ... | |
medium_convergence_00878 | OCLN and KRAS share a common interacting partner. Evidence indicates that occludin colocalizes with a nonreceptor tyrosine kinase at cell junctions and forms an immunoprecipitable complex with this kinase in vivo. Which cell type is enriched for this shared interacting partner? | basophil | Medium | convergence | {"qa_id":"medium_convergence_00878","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"OCLN and KRAS share a common interacting partner. Evidence indicates that occludin colocalizes with a nonreceptor tyrosine kinase at cell junctions and forms... | |
medium_convergence_00879 | EEF1A1 and HDAC2 share a common interacting partner. Evidence regarding this shared partner states: 'Investigating the underlying mechanisms, we show that this protein specifically associates with and uses HDAC1 and HDAC2 to trigger this heat-shock-dependent histone deacetylation.' Which protein is encoded by this shar... | Heat shock factor protein 1 | Medium | convergence | {"qa_id":"medium_convergence_00879","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EEF1A1 and HDAC2 share a common interacting partner. Evidence regarding this shared partner states: 'Investigating the underlying mechanisms, we show that th... | |
medium_convergence_00880 | L3MBTL2 and PCGF6 share a common binding partner. Biochemical evidence indicates that this partner, or its homolog, associates with PCGF-RING1A/B combinations to form complexes that prevent the incorporation of canonical PRC1 subunits such as CBX, PHC, and SCM. Which protein is encoded by this shared binding partner? | RING1 and YY1-binding protein | Medium | convergence | {"qa_id":"medium_convergence_00880","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"L3MBTL2 and PCGF6 share a common binding partner. Biochemical evidence indicates that this partner, or its homolog, associates with PCGF-RING1A/B combination... | |
medium_convergence_00881 | CBX1 and MYC share multiple interacting partners. One such shared partner is reported to directly interact with MYC and co-occupy a distal regulatory element of SOX2 to activate SOX2 expression, a mechanism likely involved in neuroectoderm differentiation. Which gene interacts with this specific shared partner? | CBX4 | Medium | convergence | {"qa_id":"medium_convergence_00881","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBX1 and MYC share multiple interacting partners. One such shared partner is reported to directly interact with MYC and co-occupy a distal regulatory element... | |
medium_convergence_00882 | LILRB1 and CD274 are both involved in more than one shared biological process. Evidence concerning one of these shared processes indicates that continuous ligation of the associated entity modulated cellular differentiation, conferred a unique phenotype upon the resultant cells, induced a profound resistance to CD95-me... | interleukin-10 production | Medium | convergence | {"qa_id":"medium_convergence_00882","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LILRB1 and CD274 are both involved in more than one shared biological process. Evidence concerning one of these shared processes indicates that continuous li... | |
medium_convergence_00883 | CDK9 and STUB1 share common interaction partners. One such shared partner is a protein that is ubiquitinated by the E3 ligase CHIP (C-terminus of Hsc70-interacting protein), leading to its proteasome-dependent degradation. Which protein is encoded by the gene corresponding to this shared interaction partner? | Profilin-1 | Medium | convergence | {"qa_id":"medium_convergence_00883","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK9 and STUB1 share common interaction partners. One such shared partner is a protein that is ubiquitinated by the E3 ligase CHIP (C-terminus of Hsc70-inter... | |
medium_convergence_00885 | FKBP5 and HSP90AA1 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'The adaptor protein encoded by the gene corresponding to that shared partner mediates the association of the molecular chaperones Hsp70 and Hsp90.' Which protein is encoded by the gene corres... | Stress-induced-phosphoprotein 1 | Medium | convergence | {"qa_id":"medium_convergence_00885","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FKBP5 and HSP90AA1 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'The adaptor protein encoded ... | |
medium_convergence_00886 | West Nile virus and Human gammaherpesvirus 8 both upregulate a specific gene. In a study of monocyte-derived dendritic cells (GSE136342), this gene showed a log2 fold change of 1.093 and an adjusted p-value of 0.02042. Which protein is encoded by this gene? | Interferon-induced protein with tetratricopeptide repeats 2 | Medium | convergence | {"qa_id":"medium_convergence_00886","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"West Nile virus and Human gammaherpesvirus 8 both upregulate a specific gene. In a study of monocyte-derived dendritic cells (GSE136342), this gene showed a ... | |
medium_convergence_00887 | Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific host gene. Experimental data from a melanoma cell line (study GSE136586) indicates that this gene exhibits a log2 fold change of approximately -1.39 and an adjusted p-value of 2.7... | Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase | Medium | convergence | {"qa_id":"medium_convergence_00887","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific host gene. Exper... | |
medium_convergence_00889 | Both Hepacivirus C and Dengue virus are known to downregulate a specific gene. Experimental data for this gene shows a log2 fold change of approximately -1.234 and an adjusted p-value of 0.0009391. Which disease is associated with this gene? | acute erythroid leukemia | Medium | convergence | {"qa_id":"medium_convergence_00889","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Hepacivirus C and Dengue virus are known to downregulate a specific gene. Experimental data for this gene shows a log2 fold change of approximately -1.2... | |
medium_convergence_00891 | Both Orthohepevirus A and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental data for this gene in hepatocytes (from study GSE135619) reports a log2 fold change of approximately 1.363 and an adjusted p-value of 0.02296. Which protein is encoded by... | E3 ubiquitin-protein ligase listerin | Medium | convergence | {"qa_id":"medium_convergence_00891","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental data fo... | |
medium_convergence_00892 | HDAC6 and CTBP2 both interact with a shared protein. Evidence indicates that this shared protein also interacts directly with histone deacetylase 3 (HDAC3). Which protein is encoded by the gene corresponding to this shared entity? | Ligand-dependent corepressor | Medium | convergence | {"qa_id":"medium_convergence_00892","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC6 and CTBP2 both interact with a shared protein. Evidence indicates that this shared protein also interacts directly with histone deacetylase 3 (HDAC3). ... | |
medium_convergence_00893 | CHMP5 and CHMP4C both interact with a specific protein. Experimental evidence indicates that this protein associates with KSHV-containing macropinosomes and interacts with signaling molecules such as EphA2R, c-Cbl, p130Cas, and Crk, as well as other ESCRT components including Hrs (ESCRT-0), EAP45 (ESCRT-II), CHMP6 (ESC... | Tumor susceptibility gene 101 protein | Medium | convergence | {"qa_id":"medium_convergence_00893","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHMP5 and CHMP4C both interact with a specific protein. Experimental evidence indicates that this protein associates with KSHV-containing macropinosomes and ... | |
medium_convergence_00894 | Both Human alphaherpesvirus 1 and Influenza A virus have been shown to downregulate a specific gene. Experimental data from a monocytic leukemia cell line (study GSE114966) indicates that this gene exhibits a log2 fold change of approximately -1.97 and an adjusted p-value of 0.0011. Which protein is encoded by this gen... | Periostin | Medium | convergence | {"qa_id":"medium_convergence_00894","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Influenza A virus have been shown to downregulate a specific gene. Experimental data from a monocytic leukemia cell line (s... | |
medium_convergence_00895 | GEMIN5 and GEMIN4 both interact with a shared protein partner. Evidence indicates that this shared partner binds directly to SMN and functions as a component of the SMN complex. Which protein is encoded by the gene corresponding to this shared partner? | Survival motor neuron protein | Medium | convergence | {"qa_id":"medium_convergence_00895","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GEMIN5 and GEMIN4 both interact with a shared protein partner. Evidence indicates that this shared partner binds directly to SMN and functions as a component... | |
medium_convergence_00896 | ATG7 and PRKN (PARK2) share common interacting partners. One such shared partner is reported to be physically associated with ATG7 in the cytoplasm, an interaction that is enhanced by initial nutrient deprivation. Which disease is connected to this specific shared partner through a biomarker relationship? | malignant pancreatic neoplasm | Medium | convergence | {"qa_id":"medium_convergence_00896","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATG7 and PRKN (PARK2) share common interacting partners. One such shared partner is reported to be physically associated with ATG7 in the cytoplasm, an inter... | |
medium_convergence_00897 | HIF1A and PLK1 share multiple interacting partners. One such shared partner has been experimentally shown to interact specifically with two subdomains of HIF-1alpha. Which protein is encoded by this specific shared partner? | Proteasome subunit alpha type-7 | Medium | convergence | {"qa_id":"medium_convergence_00897","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HIF1A and PLK1 share multiple interacting partners. One such shared partner has been experimentally shown to interact specifically with two subdomains of HIF... | |
medium_convergence_00898 | Both Human immunodeficiency virus 1 and Human mastadenovirus C are known to upregulate a specific shared gene. Experimental evidence for this gene indicates a log2 fold change of 2.234 and an adjusted p-value of 0.001351. Which cellular component is this gene located in? | plasma membrane | Medium | convergence | {"qa_id":"medium_convergence_00898","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Human mastadenovirus C are known to upregulate a specific shared gene. Experimental evidence for this gene indicates ... | |
medium_convergence_00899 | COPS4 and COPS3 each interact with multiple shared partners. Evidence concerning one such shared entity reports that a specific subunit was also found to interact with the CSN4-6-7 core. Which protein is connected to that entity through the 'encodes' relationship? | COP9 signalosome complex subunit 8 | Medium | convergence | {"qa_id":"medium_convergence_00899","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS4 and COPS3 each interact with multiple shared partners. Evidence concerning one such shared entity reports that a specific subunit was also found to int... | |
medium_convergence_00901 | Human polyomavirus 1 and Enterovirus A both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) reports a log2 fold change of approximately 1.70 and an adjusted p-value of 0.01137. Which protein is encoded by this gene? | Echinoderm microtubule-associated protein-like 4 | Medium | convergence | {"qa_id":"medium_convergence_00901","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Enterovirus A both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) reports a... | |
medium_convergence_00902 | NBN and BRCA1 share multiple protein interaction partners. One such shared partner is described by the following evidence: 'We identified new CDK phosphorylation sites on this protein and found that phosphorylation of these newly identified CDK sites induces association of this protein with the N-terminus FHA and BRCT ... | glaucoma | Medium | convergence | {"qa_id":"medium_convergence_00902","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NBN and BRCA1 share multiple protein interaction partners. One such shared partner is described by the following evidence: 'We identified new CDK phosphoryla... | |
medium_convergence_00905 | POC1B and HDAC1 share a common interacting partner. Evidence indicates that depletion of this shared luminal centriole protein, which binds to A-microtubules and interacts with POC1B to affect centriole structure and conversion (distinct from CEP295's binding to centrioles), supports its identification. Which protein i... | Centrosomal protein of 44 kDa | Medium | convergence | {"qa_id":"medium_convergence_00905","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"POC1B and HDAC1 share a common interacting partner. Evidence indicates that depletion of this shared luminal centriole protein, which binds to A-microtubules... | |
medium_convergence_00906 | MICU2 and SLC8B1 are both involved in a shared biological process. Evidence indicates that MICU1 and the entity associated with this process are the main regulators of the mitochondrial Ca(2+)-uniporter (MCU). Which biological process is this entity connected to via an 'is a' relationship? | intracellular calcium ion homeostasis | Medium | convergence | {"qa_id":"medium_convergence_00906","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MICU2 and SLC8B1 are both involved in a shared biological process. Evidence indicates that MICU1 and the entity associated with this process are the main reg... | |
medium_convergence_00908 | GRB2 and AREG both interact with a shared protein entity. Evidence indicates that this specific entity binds to the intracellular adaptor protein GRB2, suggesting an intracellular localization. Which protein is encoded by this shared entity? | Protein sprouty homolog 2 | Medium | convergence | {"qa_id":"medium_convergence_00908","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRB2 and AREG both interact with a shared protein entity. Evidence indicates that this specific entity binds to the intracellular adaptor protein GRB2, sugge... | |
medium_convergence_00909 | TNK2 and EGFR share interaction partners. One such partner is described in a study stating: 'In this study, we have identified SAM domain-carrying non-receptor tyrosine kinase, activated Cdc42-associated tyrosine kinase 1 (ACK1; also known as TNK2, tyrosine kinase non-receptor 2) as a novel binding partner of the prote... | Lymphocyte cytosolic protein 2 | Medium | convergence | {"qa_id":"medium_convergence_00909","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TNK2 and EGFR share interaction partners. One such partner is described in a study stating: 'In this study, we have identified SAM domain-carrying non-recept... | |
medium_convergence_00910 | AKT1 and AKT2 both interact with a specific shared protein. Experimental evidence for this interaction includes coimmunoprecipitation of hBVR with Akt1, as well as in-cell Förster resonance energy transfer (FRET) and glutathione S-transferase pulldown analyses that identified the pleckstrin homology domain of this shar... | heme catabolic process | Medium | convergence | {"qa_id":"medium_convergence_00910","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKT1 and AKT2 both interact with a specific shared protein. Experimental evidence for this interaction includes coimmunoprecipitation of hBVR with Akt1, as w... | |
medium_convergence_00911 | KRT17 and KRT18 both interact with a shared protein partner. Evidence regarding this partner states: 'The explanation does not appear to reside in an inability of K18 to form 10-nm filaments with K5, which it does in vitro and in vivo.' Which protein is encoded by the gene corresponding to this shared partner? | Keratin, type II cytoskeletal 5 | Medium | convergence | {"qa_id":"medium_convergence_00911","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KRT17 and KRT18 both interact with a shared protein partner. Evidence regarding this partner states: 'The explanation does not appear to reside in an inabili... | |
medium_convergence_00914 | DLG4 and SLC1A3 both interact with a specific kainate receptor subunit. Evidence indicates that PDZ domain-containing proteins, including PSD95, interact with kainate receptor subunits GluR5 and this specific subunit. Which disease is associated with this specific subunit through genomic alterations? | autosomal recessive juvenile Parkinson disease 2 | Medium | convergence | {"qa_id":"medium_convergence_00914","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLG4 and SLC1A3 both interact with a specific kainate receptor subunit. Evidence indicates that PDZ domain-containing proteins, including PSD95, interact wit... | |
medium_convergence_00915 | CHUK and CARD11 both interact with a specific shared protein. Evidence indicates that PKCδ inhibits the interaction between this shared protein and TRAF6, but does not affect the association of CARMA1 with PKCθ, Bcl10, or this shared protein. Which disease is associated with this protein through genomic alterations? | primary cutaneous marginal zone B-cell lymphoma | Medium | convergence | {"qa_id":"medium_convergence_00915","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHUK and CARD11 both interact with a specific shared protein. Evidence indicates that PKCδ inhibits the interaction between this shared protein and TRAF6, bu... | |
medium_convergence_00916 | PRKN and SPTAN1 share multiple interacting partners. One such partner is implicated in a mechanism where the recruitment of parkin is mediated through its binding to gamma-tubulin, which accumulates in the centrosome in response to misfolded proteins. Which protein is encoded by this specific interacting partner? | Tubulin gamma-1 chain | Medium | convergence | {"qa_id":"medium_convergence_00916","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKN and SPTAN1 share multiple interacting partners. One such partner is implicated in a mechanism where the recruitment of parkin is mediated through its bi... | |
medium_convergence_00917 | COPS6 and CCNH each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'The immunoprecipitation assay verified that COP9 signalosome subunit 6 (CSN6) interacted with CULA4.' Which protein is encoded by the gene corresponding to that shared partner? | Cullin-4A | Medium | convergence | {"qa_id":"medium_convergence_00917","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS6 and CCNH each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'The immunoprecipitation assay ve... | |
medium_convergence_00920 | COPB1 and CAPZA3 both interact with a shared protein partner. Evidence regarding this partner states: 'Herein we describe isolation of a subcomplex of coatomer consisting of beta- and delta-COPs that is able to bind to Golgi membranes in an ARF1- and GTP-dependent manner.' Which gene encodes this shared protein partner... | Coatomer subunit zeta-1 | Medium | convergence | {"qa_id":"medium_convergence_00920","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPB1 and CAPZA3 both interact with a shared protein partner. Evidence regarding this partner states: 'Herein we describe isolation of a subcomplex of coatom... | |
medium_convergence_00921 | PHC1 and CBX2 both interact with a shared protein partner. Experimental evidence indicates that this partner coimmunoprecipitates with a human Polycomb (Pc) homolog, the vertebrate Polycomb-group (PcG) protein BMI1, and HPH1, a human homolog of the PcG protein Polyhomeotic (Ph). Which protein is encoded by this shared ... | E3 ubiquitin-protein ligase RING1 | Medium | convergence | {"qa_id":"medium_convergence_00921","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PHC1 and CBX2 both interact with a shared protein partner. Experimental evidence indicates that this partner coimmunoprecipitates with a human Polycomb (Pc) ... | |
medium_convergence_00922 | POT1 and POLA1 both interact with a shared protein partner. Evidence regarding one such partner states: 'Conversely, a pol1 peptide spanning the last 16 residues binds primase with high affinity, and the equivalent peptide from human Pol α binds primase in an analogous fashion.' Which protein is encoded by the gene cor... | DNA primase large subunit | Medium | convergence | {"qa_id":"medium_convergence_00922","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"POT1 and POLA1 both interact with a shared protein partner. Evidence regarding one such partner states: 'Conversely, a pol1 peptide spanning the last 16 resi... | |
medium_convergence_00923 | GNA15 and GNAI3 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'In vitro binding assays reveal that this protein and RGS16 bind to Galphai and Galphao subunits of heterotrimeric G-proteins, but not to Galphas.' Which protein is encoded by that shared partner... | Regulator of G-protein signaling 5 | Medium | convergence | {"qa_id":"medium_convergence_00923","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNA15 and GNAI3 each interact with more than one shared protein partner. Evidence concerning one such shared partner states: 'In vitro binding assays reveal ... | |
medium_convergence_00924 | EIF3B and EIF3D each interact with multiple shared partners. One such partner is described in evidence stating that activating mTOR signaling with insulin increased the amount of the protein encoded by this partner bound to eIF3 by as much as five-fold. Which protein is encoded by this specific partner? | Eukaryotic translation initiation factor 4 gamma 1 | Medium | convergence | {"qa_id":"medium_convergence_00924","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF3B and EIF3D each interact with multiple shared partners. One such partner is described in evidence stating that activating mTOR signaling with insulin in... | |
medium_convergence_00925 | Dengue virus and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) shows a log2 fold change of -1.365 and an adjusted p-value of 0.0288. Which protein is encoded by this gene? | Recombining binding protein suppressor of hairless | Medium | convergence | {"qa_id":"medium_convergence_00925","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Dengue virus and Pegivirus C both downregulate a specific gene. Experimental data for this gene in a hepatoma cell line (study GSE110512) shows a log2 fold c... | |
medium_convergence_00926 | EHMT2 and NUMA1 both interact with a shared protein. Evidence indicates that this shared protein associates in vivo with SET/I2PP2A and G9a, but shows no detectable association with HDAC1 or HATs. Which protein is encoded by the gene corresponding to this shared entity? | Barrier-to-autointegration factor | Medium | convergence | {"qa_id":"medium_convergence_00926","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EHMT2 and NUMA1 both interact with a shared protein. Evidence indicates that this shared protein associates in vivo with SET/I2PP2A and G9a, but shows no det... | |
medium_convergence_00927 | CUL1 and BTRC both interact with a specific protein. Evidence indicates that TGF-beta-induced ubiquitination of this protein is associated with its phosphorylation at the beta-TrCP docking site (DS82G motif) and its physical association with Smad3 and beta-TrCP. Which protein is encoded by the gene corresponding to thi... | M-phase inducer phosphatase 1 | Medium | convergence | {"qa_id":"medium_convergence_00927","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CUL1 and BTRC both interact with a specific protein. Evidence indicates that TGF-beta-induced ubiquitination of this protein is associated with its phosphory... | |
medium_convergence_00928 | CRK and PDGFA each interact with more than one shared receptor. Evidence concerning one shared entity reports: 'The wild-type PDGF alpha-receptor, when expressed in porcine aortic endothelial cells, formed complexes with CrkII and CrkL upon ligand stimulation, which was specifically inhibited by a synthetic peptide con... | Platelet-derived growth factor receptor alpha | Medium | convergence | {"qa_id":"medium_convergence_00928","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRK and PDGFA each interact with more than one shared receptor. Evidence concerning one shared entity reports: 'The wild-type PDGF alpha-receptor, when expre... | |
medium_convergence_00929 | NFYA and SP1 both interact with a specific transcription factor. Evidence regarding this shared partner states: 'Two cDNA fragments encoding the same region of the SREBP-2 transcription factor were independently selected and two overlapping cDNA clones corresponded to the splicing factor SF3A120.' Which protein is enco... | Sterol regulatory element-binding protein 2 | Medium | convergence | {"qa_id":"medium_convergence_00929","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NFYA and SP1 both interact with a specific transcription factor. Evidence regarding this shared partner states: 'Two cDNA fragments encoding the same region ... | |
medium_convergence_00930 | HDAC6 and TOPBP1 share a common interacting partner. Experimental evidence using nuclear co-immunoprecipitation demonstrates that this shared partner interacts with ATR, Claspin, and Chk1 as part of the MutSalpha complex, and also interacts with Claspin as part of the MutLalpha complex. Which disease is associated with... | lung adenocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_00930","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC6 and TOPBP1 share a common interacting partner. Experimental evidence using nuclear co-immunoprecipitation demonstrates that this shared partner interac... | |
medium_convergence_00931 | Both Pegivirus C and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental data for this gene, derived from peripheral blood mononuclear cells in study GSE131504, reports a log2 fold change of approximately 1.886 and an adjusted p-value of 0.04714. W... | Protein S100-P | Medium | convergence | {"qa_id":"medium_convergence_00931","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Pegivirus C and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental data for thi... | |
medium_convergence_00932 | AP3S2 and PRKN (PARK2) share common interaction partners. One such shared partner is described in a study reporting an interdomain interaction involving the ear domain of the delta subunit and the sigma3 subunit of AP-3. Which protein encodes this specific shared interaction partner? | AP-3 complex subunit delta-1 | Medium | convergence | {"qa_id":"medium_convergence_00932","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AP3S2 and PRKN (PARK2) share common interaction partners. One such shared partner is described in a study reporting an interdomain interaction involving the ... | |
medium_convergence_00933 | EGFR and PDPK1 share multiple interacting partners. One such partner is characterized by evidence stating: 'Treatment of cells with growth factor induced recruitment of PDK1 to the Ser386-phosphorylated hydrophobic motif and phosphorylation of this partner at Ser227.' Which disease is associated with this specific part... | Coffin-Lowry syndrome | Medium | convergence | {"qa_id":"medium_convergence_00933","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and PDPK1 share multiple interacting partners. One such partner is characterized by evidence stating: 'Treatment of cells with growth factor induced rec... | |
medium_convergence_00934 | ALYREF and CSTF1 both interact with a shared protein partner. Evidence indicates that this partner interacts with the mRNA export factor Aly and can rescue the loss of Sub2p (the yeast homolog of UAP56), suggesting functional similarity. Which gene encodes this shared protein partner? | ATP-dependent RNA helicase DDX39A | Medium | convergence | {"qa_id":"medium_convergence_00934","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ALYREF and CSTF1 both interact with a shared protein partner. Evidence indicates that this partner interacts with the mRNA export factor Aly and can rescue t... | |
medium_convergence_00935 | RPA2 and RPA3 share a common interacting partner. Evidence regarding this shared partner states: 'Purification of [Gene A], a UvrD DNA helicase, identified a physical interaction with replication protein A (RPA), the major cellular single-stranded DNA (ssDNA)-binding protein complex.' Which gene interacts with this sha... | RBX1 | Medium | convergence | {"qa_id":"medium_convergence_00935","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RPA2 and RPA3 share a common interacting partner. Evidence regarding this shared partner states: 'Purification of [Gene A], a UvrD DNA helicase, identified a... | |
medium_convergence_00936 | CHRNA1 and CDC42 each interact with more than one shared protein partner. Evidence concerning one such shared partner indicates that it binds strongly to GTP-Cdc42 and weakly to GTP-Rac. Which protein is encoded by the gene corresponding to this specific shared partner? | Serine/threonine-protein kinase PAK 6 | Medium | convergence | {"qa_id":"medium_convergence_00936","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHRNA1 and CDC42 each interact with more than one shared protein partner. Evidence concerning one such shared partner indicates that it binds strongly to GTP... | |
medium_convergence_00937 | ARHGEF7 and CDC42 both interact with a specific protein. Experimental evidence indicates that this protein binds strongly to GTP-Cdc42 and weakly to GTP-Rac. Which protein is encoded by the gene corresponding to this interacting partner? | Serine/threonine-protein kinase PAK 6 | Medium | convergence | {"qa_id":"medium_convergence_00937","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARHGEF7 and CDC42 both interact with a specific protein. Experimental evidence indicates that this protein binds strongly to GTP-Cdc42 and weakly to GTP-Rac.... | |
medium_convergence_00938 | CTNNB1 and EP300 share multiple interacting partners. One such partner is described as a T lineage-enriched chromatin organizer and global regulator that interacts with beta-catenin and recruits it to its genomic binding sites. Which cell type is this specific partner enriched in? | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | convergence | {"qa_id":"medium_convergence_00938","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and EP300 share multiple interacting partners. One such partner is described as a T lineage-enriched chromatin organizer and global regulator that int... | |
medium_convergence_00939 | MIR499A and XBP1 are both involved in more than one shared biological process. Evidence indicates that spliced XBP1 increases smooth muscle cell (SMC) migration via PI3K/Akt activation. Which biological process, connected to this entity through a 'positively regulates' relationship, is supported by this evidence? | vascular associated smooth muscle cell migration | Medium | convergence | {"qa_id":"medium_convergence_00939","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MIR499A and XBP1 are both involved in more than one shared biological process. Evidence indicates that spliced XBP1 increases smooth muscle cell (SMC) migrat... | |
medium_convergence_00940 | Vaccinia virus and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of 8.703 and an adjusted p-value of 0.004552. Which protein does this gene product bind to? | PRTN3 | Medium | convergence | {"qa_id":"medium_convergence_00940","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) rep... | |
medium_convergence_00941 | TNFRSF1A and FADD both interact with a shared protein. Evidence regarding this shared protein states: 'We show that MDC does not prevent the interaction of the p55 TNF receptor (TR55) with FAN and the shared protein.' Which protein is encoded by this shared entity? | Tumor necrosis factor receptor type 1-associated DEATH domain protein | Medium | convergence | {"qa_id":"medium_convergence_00941","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TNFRSF1A and FADD both interact with a shared protein. Evidence regarding this shared protein states: 'We show that MDC does not prevent the interaction of t... | |
medium_convergence_00942 | Human alphaherpesvirus 1 and Human alphaherpesvirus 3 both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately 2.34 and an adjusted p-value of 0.0248. Which protein does this gene product interact with? | PRKAB2 | Medium | convergence | {"qa_id":"medium_convergence_00942","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Human alphaherpesvirus 3 both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (stu... | |
medium_convergence_00943 | Human polyomavirus 1 and Zika virus both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) reports a log2 fold change of approximately 1.40 and an adjusted p-value of approximately 0.020. Which protein is encoded by this gene? | Class E basic helix-loop-helix protein 40 | Medium | convergence | {"qa_id":"medium_convergence_00943","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Zika virus both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) reports a lo... | |
medium_convergence_00944 | KAT5 and HDAC2 both interact with a specific transcription factor. Evidence indicates that the N-terminal amino acids 106-190 of this transcription factor are required for its association with TIP60 and HDAC7, as well as for its transcriptional repression via its forkhead domain. Which protein is encoded by this transc... | Forkhead box protein P3 | Medium | convergence | {"qa_id":"medium_convergence_00944","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KAT5 and HDAC2 both interact with a specific transcription factor. Evidence indicates that the N-terminal amino acids 106-190 of this transcription factor ar... | |
medium_convergence_00945 | B2M and TAP1 both interact with a shared protein partner. Evidence regarding this partner indicates that photolabeling experiments with 8-azido-ATP demonstrate a cooperative interaction between two nucleotide-binding domains (NBDs) that can be stimulated by peptide. Which disease is associated with this protein partner... | psoriasis | Medium | convergence | {"qa_id":"medium_convergence_00945","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"B2M and TAP1 both interact with a shared protein partner. Evidence regarding this partner indicates that photolabeling experiments with 8-azido-ATP demonstra... | |
medium_convergence_00946 | PPP2CA and PPP2R1B both interact with multiple shared gene products. One such shared entity is described by the following evidence: 'Specifically, B56alpha, B56beta, and B56epsilon complexed with the protein phosphatase 2A A and C subunits localize to the cytoplasm, whereas the nuclear-localized B56 isoform, B56gamma1,... | Houge-Janssens syndrome | Medium | convergence | {"qa_id":"medium_convergence_00946","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PPP2CA and PPP2R1B both interact with multiple shared gene products. One such shared entity is described by the following evidence: 'Specifically, B56alpha, ... | |
medium_convergence_00947 | STX1A and VAMP8 share a common interacting partner. Experimental evidence indicates that alpha-SNAP binds directly to syntaxin 1A and weakly to SNAP-25, but does not bind to synaptobrevin II. Which disease is associated with this shared interacting partner? | cocaine dependence | Medium | convergence | {"qa_id":"medium_convergence_00947","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STX1A and VAMP8 share a common interacting partner. Experimental evidence indicates that alpha-SNAP binds directly to syntaxin 1A and weakly to SNAP-25, but ... | |
medium_convergence_00948 | CREBBP and HDAC1 share common interaction partners. One such partner is described in evidence stating: 'Coexpression of CREB-binding protein (CBP)/p300 with this partner has an additive effect on promoter activity, and the proteins were demonstrated to interact physically.' Which disease is associated with this specifi... | mammary neoplasms, animal | Medium | convergence | {"qa_id":"medium_convergence_00948","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and HDAC1 share common interaction partners. One such partner is described in evidence stating: 'Coexpression of CREB-binding protein (CBP)/p300 with ... | |
medium_convergence_00949 | HIF1A and HSP90AA1 share multiple interacting partners. One such shared partner is implicated in a mechanism where the cytoplasmic lncRNA LINK-A mediates HB-EGF-triggered, EGFR:GPNMB heterodimer-dependent phosphorylation of HIF1α at Tyr 565 and Ser 797 by a kinase encoded by this partner gene and LRRK2, respectively. W... | Protein-tyrosine kinase 6 | Medium | convergence | {"qa_id":"medium_convergence_00949","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HIF1A and HSP90AA1 share multiple interacting partners. One such shared partner is implicated in a mechanism where the cytoplasmic lncRNA LINK-A mediates HB-... | |
medium_convergence_00950 | DNMT1 and E2F6 both interact with a specific Polycomb group protein. Evidence indicates that this protein, identified as Enhancer of Zeste homolog 2, interacts within the context of Polycomb repressive complexes 2 and 3 (PRC2/3) with DNA methyltransferases (DNMTs) and associates with DNMT activity in vivo. Which protei... | Histone-lysine N-methyltransferase EZH2 | Medium | convergence | {"qa_id":"medium_convergence_00950","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNMT1 and E2F6 both interact with a specific Polycomb group protein. Evidence indicates that this protein, identified as Enhancer of Zeste homolog 2, interac... | |
medium_convergence_00951 | KAT5 and RAD51 both interact with a shared protein partner. Evidence regarding one such partner states: 'Using the yeast two-hybrid system, we isolated a cDNA encoding a novel human protein, named [the shared partner], that strongly interacts with human Rad51 recombinase.' Which cell type is enriched for this specific ... | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_00951","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KAT5 and RAD51 both interact with a shared protein partner. Evidence regarding one such partner states: 'Using the yeast two-hybrid system, we isolated a cDN... | |
medium_convergence_00952 | NUP50 and KPNB1 both interact with a shared protein. Evidence regarding this shared protein states: 'Binding affinity studies showed that all importin alpha proteins from humans or Xenopus bind their import receptor (importin beta) and their export receptor (CAS) with only marginal differences.' Which protein is encode... | Importin subunit alpha-3 | Medium | convergence | {"qa_id":"medium_convergence_00952","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NUP50 and KPNB1 both interact with a shared protein. Evidence regarding this shared protein states: 'Binding affinity studies showed that all importin alpha ... | |
medium_convergence_00953 | KIF5B and RHOA both interact with a shared protein. Evidence indicates that this shared entity is the nonneuronal homologue of SNAP25 and was confirmed to interact with kinesin. Which protein is encoded by this shared entity? | Synaptosomal-associated protein 23 | Medium | convergence | {"qa_id":"medium_convergence_00953","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KIF5B and RHOA both interact with a shared protein. Evidence indicates that this shared entity is the nonneuronal homologue of SNAP25 and was confirmed to in... | |
medium_convergence_00954 | SLC3A2 and BSG both interact with a shared protein partner. Evidence regarding this partner states: 'We show that h4F2hc also associates with other mammalian light chains, e.g. a transporter from mouse and human which are approximately 48% identical with LAT1 and thus belong to the same family of glycoprotein-associate... | Y+L amino acid transporter 1 | Medium | convergence | {"qa_id":"medium_convergence_00954","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SLC3A2 and BSG both interact with a shared protein partner. Evidence regarding this partner states: 'We show that h4F2hc also associates with other mammalian... | |
medium_convergence_00955 | Both Human respirovirus 3 and Severe acute respiratory syndrome-related coronavirus are reported to downregulate a specific host gene. Experimental data for this gene in non-small cell lung adenocarcinoma cells (study GSE147507) show a log2 fold change of approximately -1.43 and an adjusted p-value of 0.0493. Which cel... | plasma membrane | Medium | convergence | {"qa_id":"medium_convergence_00955","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human respirovirus 3 and Severe acute respiratory syndrome-related coronavirus are reported to downregulate a specific host gene. Experimental data for ... | |
medium_convergence_00956 | COPS5 and DDB1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Nonetheless, the counteracting effect of this entity on X stabilization requires the interaction between this entity and DDB1.' Which protein is encoded by the gene corresponding to this shared entity? | DNA damage-binding protein 2 | Medium | convergence | {"qa_id":"medium_convergence_00956","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS5 and DDB1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Nonetheless, the counteracting effect of this... | |
medium_convergence_00958 | RAD51 and EXO1 both interact with a common protein partner. Evidence regarding this partner indicates that in assays using purified components, phosphorylation of RAD51 by c-Abl enhances complex formation between RAD51 and this partner, which cooperates with RAD51 in recombination and repair. Which disease is associate... | cervical squamous cell carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00958","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAD51 and EXO1 both interact with a common protein partner. Evidence regarding this partner indicates that in assays using purified components, phosphorylati... | |
medium_convergence_00959 | MAPK8 and MAPK9 each interact with more than one shared gene product. Evidence concerning one shared entity reports that a dual-specificity phosphatase binds to and inactivates p38 MAPK and JNK/SAPK, but not ERK. Which protein is encoded by that entity? | Dual specificity protein phosphatase 16 | Medium | convergence | {"qa_id":"medium_convergence_00959","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAPK8 and MAPK9 each interact with more than one shared gene product. Evidence concerning one shared entity reports that a dual-specificity phosphatase binds... | |
medium_convergence_00960 | CDKN1B and GNB2L1 share interaction partners. One such shared partner is described in evidence stating: 'Several novel proteins (INCA1, KARCA1, and PROCA1) as well as the known proteins GPS2 (G-protein pathway suppressor 2), Ku70, receptor for activated protein kinase C1/guanine nucleotide-binding protein beta-2-like-1... | Cyclin-A1 | Medium | convergence | {"qa_id":"medium_convergence_00960","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDKN1B and GNB2L1 share interaction partners. One such shared partner is described in evidence stating: 'Several novel proteins (INCA1, KARCA1, and PROCA1) a... | |
medium_convergence_00962 | Histamine secretion by mast cells and histamine secretion by basophils are both types of a specific biological process. Evidence regarding this process states: 'The regulated release of histamine by a mast cell or group of mast cells.' Which biological process is this specific process a part of? | histamine production involved in inflammatory response | Medium | convergence | {"qa_id":"medium_convergence_00962","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Histamine secretion by mast cells and histamine secretion by basophils are both types of a specific biological process. Evidence regarding this process state... | |
medium_convergence_00963 | COPS4 and CUL4B both interact with a shared protein partner. Evidence regarding this partner states: 'We demonstrated that the C-terminal half of the protein encoded by the gene corresponding to this shared partner encompassing the PCI domain is responsible for interaction with CSN2, CSN3, and CSN4 subunits and is requ... | COP9 signalosome complex subunit 1 | Medium | convergence | {"qa_id":"medium_convergence_00963","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COPS4 and CUL4B both interact with a shared protein partner. Evidence regarding this partner states: 'We demonstrated that the C-terminal half of the protein... | |
medium_convergence_00964 | GATA4 and FOXH1 both physically interact with a specific transcription factor. Experimental evidence indicates that this interaction involves the C-terminal zinc finger of GATA4 and a C-terminal extension of the partner protein; specifically, a C-terminally extended homeodomain of this partner is required for binding t... | myotonic dystrophy | Medium | convergence | {"qa_id":"medium_convergence_00964","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GATA4 and FOXH1 both physically interact with a specific transcription factor. Experimental evidence indicates that this interaction involves the C-terminal ... | |
medium_convergence_00965 | The genes SLC29A4 and SLC22A2 both enable a specific molecular function. Evidence regarding this function states: 'The plasma membrane monoamine transporter (PMAT) and organic cation transporter 3 (OCT3) are the two most prominent low-affinity, high-capacity (i.e., uptake(2)) transporters for endogenous biogenic amines... | monoamine transport | Medium | convergence | {"qa_id":"medium_convergence_00965","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The genes SLC29A4 and SLC22A2 both enable a specific molecular function. Evidence regarding this function states: 'The plasma membrane monoamine transporter ... | |
medium_convergence_00966 | TRIM28 and BRD4 both interact with a specific shared protein. Experimental evidence indicates that this shared protein is part of the replication factor C (RFC) complex, as coimmunoprecipitation experiments demonstrated that endogenous and transfected BRD4 interacts with RFC, the conserved five-subunit complex essentia... | Replication factor C subunit 4 | Medium | convergence | {"qa_id":"medium_convergence_00966","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and BRD4 both interact with a specific shared protein. Experimental evidence indicates that this shared protein is part of the replication factor C (R... | |
medium_convergence_00967 | Both Human alphaherpesvirus 1 and Zaire ebolavirus are known to downregulate a specific host gene. In a study using a monocytic leukemia cell line (GSE114966), this gene exhibited a log2 fold change of approximately -1.241 and an adjusted p-value of 0.002936. Which protein is encoded by this gene? | Urokinase-type plasminogen activator | Medium | convergence | {"qa_id":"medium_convergence_00967","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Zaire ebolavirus are known to downregulate a specific host gene. In a study using a monocytic leukemia cell line (GSE114966... | |
medium_convergence_00969 | CREBBP and CTNNB1 share multiple binding partners. One such partner is characterized by evidence stating that transfected and endogenous human Pygopus2 and CBP proteins co-immunoprecipitate in HEK-293 cells and co-localize in SW480 colorectal cancer cells. Which disease is associated with this specific entity via a bio... | glioma | Medium | convergence | {"qa_id":"medium_convergence_00969","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and CTNNB1 share multiple binding partners. One such partner is characterized by evidence stating that transfected and endogenous human Pygopus2 and C... | |
medium_convergence_00970 | Adalimumab and Alemtuzumab both interact with a specific shared drug. Evidence regarding this shared entity states: 'The addition of monoclonal antibodies, such as rituximab and alemtuzumab, to purine analogues alone or in combination seems to be even more effective for chemotherapy-naive and pretreated CLL patients.' ... | hairy cell leukemia | Medium | convergence | {"qa_id":"medium_convergence_00970","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Adalimumab and Alemtuzumab both interact with a specific shared drug. Evidence regarding this shared entity states: 'The addition of monoclonal antibodies, s... | |
medium_convergence_00971 | CD3D and CD247 are both components of multiple cellular structures. One specific shared structure is described by the evidence: 'The octameric TCR-CD3 complex is assembled with 1:1:1:1 stoichiometry of TCRαβ:CD3γε:CD3δε:CD3ζζ.' What is the immediate parent category (is_a relationship) of this specific shared structure? | T cell receptor complex | Medium | convergence | {"qa_id":"medium_convergence_00971","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CD3D and CD247 are both components of multiple cellular structures. One specific shared structure is described by the evidence: 'The octameric TCR-CD3 comple... | |
medium_convergence_00972 | LY96 and RIPK1 both interact with a shared protein. Evidence indicates that this shared protein, referred to as a receptor-interacting serine/threonine-protein kinase, can be co-immunoprecipitated with RIP, TRAF2, and TNFR1 in mammalian cells. Which protein is encoded by this shared entity? | Receptor-interacting serine/threonine-protein kinase 3 | Medium | convergence | {"qa_id":"medium_convergence_00972","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LY96 and RIPK1 both interact with a shared protein. Evidence indicates that this shared protein, referred to as a receptor-interacting serine/threonine-prote... | |
medium_convergence_00973 | PARP1 and EZH2 share multiple interacting partners. One such shared partner has been shown to interact directly with both proteins, a finding validated by immunofluorescence, co-immunoprecipitation (CO-IP), and GST pull-down assays, with interaction regions mapped using deletion mutants. Which gene is bound by this spe... | WDR48 | Medium | convergence | {"qa_id":"medium_convergence_00973","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and EZH2 share multiple interacting partners. One such shared partner has been shown to interact directly with both proteins, a finding validated by im... | |
medium_convergence_00974 | PCM1 and UBR5 share multiple interaction partners. One of these shared partners is known to associate with an E3 ligase complex containing EDD, DDB1, and VPRBP proteins (the EDVP complex). Which cell type is this specific shared partner enriched in? | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_00974","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PCM1 and UBR5 share multiple interaction partners. One of these shared partners is known to associate with an E3 ligase complex containing EDD, DDB1, and VPR... | |
medium_convergence_00975 | ALYREF and NUP35 both interact with a shared protein. Evidence indicates that the adaptor protein Aly (encoded by ALYREF) and Thoc5 can simultaneously bind to non-overlapping sites on the NXF1-NXT1 complex. Which biological process is this shared protein involved in? | mRNA export from nucleus | Medium | convergence | {"qa_id":"medium_convergence_00975","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ALYREF and NUP35 both interact with a shared protein. Evidence indicates that the adaptor protein Aly (encoded by ALYREF) and Thoc5 can simultaneously bind t... | |
medium_convergence_00976 | Cerebellar stellate cell differentiation and eurydendroid cell differentiation share a common biological process. Evidence regarding one shared entity states: 'The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar stellate cell. Differentiatio... | hindbrain development | Medium | convergence | {"qa_id":"medium_convergence_00976","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Cerebellar stellate cell differentiation and eurydendroid cell differentiation share a common biological process. Evidence regarding one shared entity states... | |
medium_convergence_00977 | CDC73 and CTDP1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'By purifying cellular parafibromin and characterizing its associated proteins, we have identified a human counterpart to the yeast Paf1 complex including homologs of Leo1, Paf1, and this entity.' Which cell ... | basophil | Medium | convergence | {"qa_id":"medium_convergence_00977","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDC73 and CTDP1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'By purifying cellular parafibromin and chara... | |
medium_convergence_00979 | Cyclosporine and Dapsone share a common drug interaction partner. Clinical evidence indicates that therapy with this shared partner for toxoplasmosis in heart transplant recipients leads to a decrease in cyclosporine concentration. Which disease is this shared drug indicated for? | rheumatic fever | Medium | convergence | {"qa_id":"medium_convergence_00979","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Cyclosporine and Dapsone share a common drug interaction partner. Clinical evidence indicates that therapy with this shared partner for toxoplasmosis in hear... | |
medium_convergence_00980 | PDCD6IP and YAP1 share common interaction partners. One such partner is distinguished by experimental evidence confirming that it, along with ARRDC3 (but not other α-arrestin family proteins), interacts with YAP1. Which cell type is this specific shared partner enriched in? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_00980","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PDCD6IP and YAP1 share common interaction partners. One such partner is distinguished by experimental evidence confirming that it, along with ARRDC3 (but not... | |
medium_convergence_00981 | TGOLN2 and CD274 share common interaction partners. One such partner is described by the following evidence: 'Under physiological conditions when TGN38 is not overexpressed, it interacts with integrin beta 1.' Which disease is associated with this specific interaction partner? | hyperthyroidism | Medium | convergence | {"qa_id":"medium_convergence_00981","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TGOLN2 and CD274 share common interaction partners. One such partner is described by the following evidence: 'Under physiological conditions when TGN38 is no... | |
medium_convergence_00982 | Vaccinia virus and Measles morbillivirus both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of -2.645 and an adjusted p-value of 0.02383. Which protein is encoded by this gene? | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 | Medium | convergence | {"qa_id":"medium_convergence_00982","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Measles morbillivirus both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE... | |
medium_convergence_00983 | Enterovirus A and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) shows a log2 fold change of approximately -2.196 and an adjusted p-value of 0.006982. Which protein is encoded by this gene? | Nexilin | Medium | convergence | {"qa_id":"medium_convergence_00983","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Enterovirus A and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) shows a log2 fo... |
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