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medium_convergence_01200 | PARP1 and USP51 both interact with a specific shared protein. Evidence indicates that this shared protein is a substrate that is bound, deubiquitinated, and stabilized by USP51, as identified through screening a human deubiquitinase library. Which gene encodes this shared protein? | Zinc finger E-box-binding homeobox 1 | Medium | convergence | {"qa_id":"medium_convergence_01200","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and USP51 both interact with a specific shared protein. Evidence indicates that this shared protein is a substrate that is bound, deubiquitinated, and ... | |
medium_convergence_01202 | MTOR and ATP6V1D share a common binding partner. Evidence indicates that this shared partner binds to the TOR complex specifically, independently of its ability to bind TSC2, through separate interactions with the mTOR catalytic domain and with LST8. Which protein is encoded by the gene corresponding to this shared par... | GTP-binding protein Rheb | Medium | convergence | {"qa_id":"medium_convergence_01202","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MTOR and ATP6V1D share a common binding partner. Evidence indicates that this shared partner binds to the TOR complex specifically, independently of its abil... | |
medium_convergence_01203 | ELL2 and AFF1 share common interaction partners. One such shared partner is supported by evidence stating: 'In addition, endogenous [the shared partner] also exhibited the capacity to interact with ELL2.' Which cell type is this shared partner enriched in? | mucosal-associated invariant T cell | Medium | convergence | {"qa_id":"medium_convergence_01203","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ELL2 and AFF1 share common interaction partners. One such shared partner is supported by evidence stating: 'In addition, endogenous [the shared partner] also... | |
medium_convergence_01205 | ERBB2 and ARHGEF11 share a common binding partner. Evidence regarding this shared partner states: 'Here we show that Plexin B2 associates directly with two members of a recently identified family of Dbl homology/pleckstrin homology containing guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and Leukemia-associa... | Plexin-B1 | Medium | convergence | {"qa_id":"medium_convergence_01205","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERBB2 and ARHGEF11 share a common binding partner. Evidence regarding this shared partner states: 'Here we show that Plexin B2 associates directly with two m... | |
medium_convergence_01206 | CDK2 and MCM3 both interact with a shared protein partner. Evidence regarding one such partner states: 'In vitro binding assays indicate that MCM3 does not interact directly with Stat1, suggesting that the presence of MCM3 in the group of Stat1TAD-interacting proteins is due to the association of MCM3 with [the shared ... | DNA replication licensing factor MCM5 | Medium | convergence | {"qa_id":"medium_convergence_01206","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK2 and MCM3 both interact with a shared protein partner. Evidence regarding one such partner states: 'In vitro binding assays indicate that MCM3 does not i... | |
medium_convergence_01207 | GNAI3 and GNA14 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'In vitro binding assays reveal that RGS5 and this protein bind to Galphai and Galphao subunits of heterotrimeric G-proteins, but not to Galphas.' Which disease is associated with that speci... | breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_01207","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GNAI3 and GNA14 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'In vitro binding assays re... | |
medium_convergence_01208 | MECP2 and HIST1H4A share multiple binding partners. One shared partner is a transcriptional repressor that binds methylated DNA assembled into chromatin and cofractionates with Sin3 and histone deacetylase. Which disease is associated with this entity via a biomarker relationship? | leukemia | Medium | convergence | {"qa_id":"medium_convergence_01208","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MECP2 and HIST1H4A share multiple binding partners. One shared partner is a transcriptional repressor that binds methylated DNA assembled into chromatin and ... | |
medium_convergence_01210 | CDK2 and PARP1 both interact with a shared protein. Evidence indicates that CDK2, in association with cyclin A or cyclin E, directly binds to this shared protein. Which protein is encoded by the gene corresponding to this shared entity? | Catenin beta-1 | Medium | convergence | {"qa_id":"medium_convergence_01210","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK2 and PARP1 both interact with a shared protein. Evidence indicates that CDK2, in association with cyclin A or cyclin E, directly binds to this shared pro... | |
medium_convergence_01211 | XRCC6 and HIST1H1C (H1-2) share common interacting partners. One such shared partner is described in evidence stating: 'Tandem affinity purification reveals that Iduna binds to a number of proteins that are either PARsylated or bind PAR including PAR polymerase-1, 2 (PARP1, 2), nucleolin, DNA ligase III, KU70, KU86, XR... | E3 ubiquitin-protein ligase RNF146 | Medium | convergence | {"qa_id":"medium_convergence_01211","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"XRCC6 and HIST1H1C (H1-2) share common interacting partners. One such shared partner is described in evidence stating: 'Tandem affinity purification reveals ... | |
medium_convergence_01212 | FANCE and ATRIP each share a binding partner with another gene. Evidence concerning one of these shared partners states: 'The human protein reportedly functions as a molecular adaptor within the FA nuclear complex, bridging between the subcomplexes A:G and C:E.' Which gene does this shared partner interact with? | GINS2 | Medium | convergence | {"qa_id":"medium_convergence_01212","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FANCE and ATRIP each share a binding partner with another gene. Evidence concerning one of these shared partners states: 'The human protein reportedly functi... | |
medium_convergence_01214 | BMP5 and BMP7 both bind to a specific receptor. Experimental evidence indicates that OP-1 (BMP7) binds efficiently to ALK-2 and ALK-6, but less efficiently to ALK-3, whereas BMP-4 binds efficiently to ALK-3 and ALK-6. Based on this binding profile, which receptor is the shared binding partner for BMP5 and BMP7, and whi... | ACVR1B | Medium | convergence | {"qa_id":"medium_convergence_01214","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMP5 and BMP7 both bind to a specific receptor. Experimental evidence indicates that OP-1 (BMP7) binds efficiently to ALK-2 and ALK-6, but less efficiently t... | |
medium_convergence_01215 | Both Human orthopneumovirus and Severe acute respiratory syndrome-related coronavirus are reported to upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) indicate a log2 fold change of approximately 1.399 and an adjusted p-value of 0.04138. Which biological proc... | potassium ion transport | Medium | convergence | {"qa_id":"medium_convergence_01215","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human orthopneumovirus and Severe acute respiratory syndrome-related coronavirus are reported to upregulate a specific gene. Experimental data for this ... | |
medium_convergence_01216 | ESR1 and CIC share multiple interacting partners. One such shared partner exhibits an estrogen-responsive interaction with ERalpha. Which protein is encoded by this shared partner? | Paired amphipathic helix protein Sin3a | Medium | convergence | {"qa_id":"medium_convergence_01216","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and CIC share multiple interacting partners. One such shared partner exhibits an estrogen-responsive interaction with ERalpha. Which protein is encoded ... | |
medium_convergence_01217 | Thiethylperazine and Scopolamine both interact with a specific shared drug. Evidence indicates that combinations of this shared drug with other antiparkinsonian agents, such as scopolamine and diphenhydramine, were studied regarding the manifestation of Parkinson-like symptoms in animal models. Which disease is this sh... | swine influenza | Medium | convergence | {"qa_id":"medium_convergence_01217","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Thiethylperazine and Scopolamine both interact with a specific shared drug. Evidence indicates that combinations of this shared drug with other antiparkinson... | |
medium_convergence_01218 | DLST and MYC each interact with more than one shared gene product. Evidence concerning one of these shared entities reports that its upregulation increased binding with c-Myc and activated c-Myc, which induced the expression of CCND1/CDK4, promoting glioma cell temozolomide resistance and proliferation. Which protein i... | Nucleosome assembly protein 1-like 1 | Medium | convergence | {"qa_id":"medium_convergence_01218","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLST and MYC each interact with more than one shared gene product. Evidence concerning one of these shared entities reports that its upregulation increased b... | |
medium_convergence_01219 | INADL and YAP1 share multiple interacting partners. One such shared partner is described by evidence stating: 'We have shown that in human embryonic kidney (HEK) 293 cells, the complex formation between transcriptional co-activators YAPs (Yes kinase-associated proteins) and Lats kinases requires the intact WW domains o... | Serine/threonine-protein kinase LATS2 | Medium | convergence | {"qa_id":"medium_convergence_01219","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"INADL and YAP1 share multiple interacting partners. One such shared partner is described by evidence stating: 'We have shown that in human embryonic kidney (... | |
medium_convergence_01220 | COMMD1 and CUL3 both interact with a specific shared protein. Experimental evidence regarding this protein states: 'To explore how a CUL3-[protein] complex might operate, we immunoprecipitated [protein] and found that it associated strongly with WNK isoforms and CUL3, but not with other components of the pathway [SPAK/... | pseudohypoaldosteronism type 2A | Medium | convergence | {"qa_id":"medium_convergence_01220","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COMMD1 and CUL3 both interact with a specific shared protein. Experimental evidence regarding this protein states: 'To explore how a CUL3-[protein] complex m... | |
medium_convergence_01221 | ASF1A and STK4 share a common interaction partner. Evidence indicates that hAsf1 proteins interact directly with the p60 subunit of hCAF-1. Which disease is associated with this shared entity via a biomarker relationship? | leukemia | Medium | convergence | {"qa_id":"medium_convergence_01221","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ASF1A and STK4 share a common interaction partner. Evidence indicates that hAsf1 proteins interact directly with the p60 subunit of hCAF-1. Which disease is ... | |
medium_convergence_01222 | BCL9 and ARID1A both interact with a specific member of the Pygopus family. Evidence indicates that this specific entity can functionally replace Legless (Lgs) in both cultured cells and in vivo, and that this rescue activity depends on the entity's ability to bind Pygo. What molecular function is enabled by this entit... | protein binding | Medium | convergence | {"qa_id":"medium_convergence_01222","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BCL9 and ARID1A both interact with a specific member of the Pygopus family. Evidence indicates that this specific entity can functionally replace Legless (Lg... | |
medium_convergence_01223 | Morphine and Meclizine share a common interacting drug. Evidence regarding this shared entity states: 'While tricyclics had no effect on basal pain responsivity, they potentiated morphine analgesia in rank-order with their potency as TLR4 inhibitors.' Which disease is this shared drug indicated for? | fibromyalgia | Medium | convergence | {"qa_id":"medium_convergence_01223","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Morphine and Meclizine share a common interacting drug. Evidence regarding this shared entity states: 'While tricyclics had no effect on basal pain responsiv... | |
medium_convergence_01224 | CDK2 and ORC3 both interact with a specific shared protein partner. Experimental evidence regarding this partner describes the following binary interactions: HsOrc2-HsOrc3, HsOrc2-HsOrc4, HsOrc3-HsOrc4, HsOrc2-HsOrc6, and HsOrc3-HsOrc6. Which protein is encoded by the gene corresponding to this shared partner? | Origin recognition complex subunit 6 | Medium | convergence | {"qa_id":"medium_convergence_01224","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK2 and ORC3 both interact with a specific shared protein partner. Experimental evidence regarding this partner describes the following binary interactions:... | |
medium_convergence_01225 | ALK and YWHAG share common interaction partners. One such shared partner is implicated in a study reporting that in 293 cells, fibroblasts, and human ALK-positive lymphoma cell lines, the fusion protein NPM-ALK binds to this partner and induces its phosphorylation. Which protein is encoded by the gene corresponding to ... | Breast cancer anti-estrogen resistance protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01225","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ALK and YWHAG share common interaction partners. One such shared partner is implicated in a study reporting that in 293 cells, fibroblasts, and human ALK-pos... | |
medium_convergence_01226 | SMAD1 and BMPR1A both interact with a specific E3 ubiquitin ligase. Evidence regarding this ligase states: 'In the region of LMP responsible for bone formation, there is a motif that directly interacts with the [ligase] WW2 domain and can effectively compete with the [ligase] and Smad5 for binding.' Which protein is en... | E3 ubiquitin-protein ligase SMURF1 | Medium | convergence | {"qa_id":"medium_convergence_01226","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD1 and BMPR1A both interact with a specific E3 ubiquitin ligase. Evidence regarding this ligase states: 'In the region of LMP responsible for bone formati... | |
medium_convergence_01228 | Vaccinia virus and Human mastadenovirus C both upregulate a specific gene in cervical adenocarcinoma cells. Experimental data for this gene shows a log2 fold change of approximately 3.46 and an adjusted p-value of approximately 2.37e-05. Which protein is encoded by this gene? | Monocarboxylate transporter 4 | Medium | convergence | {"qa_id":"medium_convergence_01228","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Human mastadenovirus C both upregulate a specific gene in cervical adenocarcinoma cells. Experimental data for this gene shows a log2 fold... | |
medium_convergence_01230 | Measles morbillivirus and Pegivirus C both upregulate a specific gene. Experimental data for this gene in pleural mesothelioma cells (study GSE117668) reports a log2 fold change of approximately 2.69 and an adjusted p-value of 0.0045. Which protein does this gene product interact with? | BRCA1 | Medium | convergence | {"qa_id":"medium_convergence_01230","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Measles morbillivirus and Pegivirus C both upregulate a specific gene. Experimental data for this gene in pleural mesothelioma cells (study GSE117668) report... | |
medium_convergence_01231 | BRD4 and ANLN both interact with a shared protein entity. Experimental evidence indicates that this entity is part of replication factor C (RFC), a conserved five-subunit complex essential for DNA replication, as demonstrated by coimmunoprecipitation experiments showing interactions with both endogenous and transfected... | hepatocellular carcinoma | Medium | convergence | {"qa_id":"medium_convergence_01231","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD4 and ANLN both interact with a shared protein entity. Experimental evidence indicates that this entity is part of replication factor C (RFC), a conserved... | |
medium_convergence_01232 | Vaccinia virus and Zaire ebolavirus both downregulate a specific host gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately -2.056 and an adjusted p-value of 0.005168. What molecular function is enabled by this gene? | carbohydrate binding | Medium | convergence | {"qa_id":"medium_convergence_01232","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Zaire ebolavirus both downregulate a specific host gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE... | |
medium_convergence_01233 | Both Human immunodeficiency virus 1 and Dengue virus are reported to downregulate a specific gene. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately -1.30 and an adjusted p-value of 0.0068. What protein is encoded by this gene? | Stonin-1 | Medium | convergence | {"qa_id":"medium_convergence_01233","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Dengue virus are reported to downregulate a specific gene. In a study of macrophages (GSE108897), this gene exhibited... | |
medium_convergence_01234 | COMMD1 and ELOB both interact with a shared protein. Evidence regarding this shared protein states: 'Like other SOCS family members, SOCS-6 binds to elongins B and C through its SOCS box, suggesting that it might act as an E3 ubiquitin ligase that targets proteins bound to its SH2 domain for ubiquitination and proteaso... | SCAMP1 | Medium | convergence | {"qa_id":"medium_convergence_01234","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"COMMD1 and ELOB both interact with a shared protein. Evidence regarding this shared protein states: 'Like other SOCS family members, SOCS-6 binds to elongins... | |
medium_convergence_01235 | Both Human alphaherpesvirus 3 and Zika virus are known to downregulate a specific gene. Experimental data from a melanoma cell line study (GSE136586) indicates that this gene exhibits a log2 fold change of approximately -1.168 and an adjusted p-value of 2.019e-05. Which disease is associated with this gene as a biomark... | kidney neoplasm | Medium | convergence | {"qa_id":"medium_convergence_01235","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Zika virus are known to downregulate a specific gene. Experimental data from a melanoma cell line study (GSE136586) indicat... | |
medium_convergence_01237 | Diffuse bistratified amacrine cells and fountain amacrine cells both establish synaptic input/output connections within specific retinal sublaminar layers. One shared anatomical region is characterized by evidence describing a bistratified amacrine cell with a small dendritic field that has post-synaptic terminals in S... | sublaminar layers S2 or S3 | Medium | convergence | {"qa_id":"medium_convergence_01237","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Diffuse bistratified amacrine cells and fountain amacrine cells both establish synaptic input/output connections within specific retinal sublaminar layers. O... | |
medium_convergence_01238 | DVL2 and SMAD2 share a common binding partner. Experimental evidence indicates that this shared partner interacts with receptor-activated Smads (R-Smads), specifically Smad1, Smad2, and Smad3, but does not interact with Smad4. Which protein is encoded by the gene corresponding to this shared binding partner? | E3 ubiquitin-protein ligase SMURF2 | Medium | convergence | {"qa_id":"medium_convergence_01238","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DVL2 and SMAD2 share a common binding partner. Experimental evidence indicates that this shared partner interacts with receptor-activated Smads (R-Smads), sp... | |
medium_convergence_01239 | IGF1R and LIMK1 share common interaction partners. One such partner is implicated in evidence stating that 'Both MDM2 and beta-arrestin co-immunoprecipitated with the IGF-1R.' Which cell type is enriched for this specific shared partner? | non-classical monocyte | Medium | convergence | {"qa_id":"medium_convergence_01239","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IGF1R and LIMK1 share common interaction partners. One such partner is implicated in evidence stating that 'Both MDM2 and beta-arrestin co-immunoprecipitated... | |
medium_convergence_01240 | MECOM and BRD4 both interact with a shared protein. Experimental evidence indicates that Evi1 (the protein product of MECOM) interacts with this specific shared entity, but does not interact with other MBD family members such as Mbd1, Mbd2, Mbd4, or MeCP2. Which disease is associated with this shared entity via a bioma... | autism spectrum disorder | Medium | convergence | {"qa_id":"medium_convergence_01240","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MECOM and BRD4 both interact with a shared protein. Experimental evidence indicates that Evi1 (the protein product of MECOM) interacts with this specific sha... | |
medium_convergence_01241 | Fluconazole and Clotrimazole both interact with a specific drug. Evidence regarding co-prescription patterns for this drug indicates that Solifenacin (34.9%), clarithromycin (18.1%), the drug in question (15.1%), and donepezil (10.4%) were frequently found in its co-prescriptions. Which disease is this drug indicated f... | benign prostatic hyperplasia | Medium | convergence | {"qa_id":"medium_convergence_01241","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Fluconazole and Clotrimazole both interact with a specific drug. Evidence regarding co-prescription patterns for this drug indicates that Solifenacin (34.9%)... | |
medium_convergence_01242 | CENPA and BUB1B both interact with a shared protein complex component. Evidence indicates that CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of three new human centromere proteins (CENP-M, CENP-N and a specific centromere protein), along with CENP-U, CENP-C and CENP... | short stature and microcephaly with genital anomalies | Medium | convergence | {"qa_id":"medium_convergence_01242","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CENPA and BUB1B both interact with a shared protein complex component. Evidence indicates that CENP-A nucleosomes directly recruit a proximal CENP-A nucleoso... | |
medium_convergence_01243 | HSPA1A and RPA1 both interact with a shared protein. Evidence indicates that this shared protein is associated with RPA1 and RPA2, which are components of the replication protein A (RPA) complex. Which protein is encoded by this shared entity? | TP53-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01243","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA1A and RPA1 both interact with a shared protein. Evidence indicates that this shared protein is associated with RPA1 and RPA2, which are components of th... | |
medium_convergence_01246 | BRCA1 and BRCC3 share common interacting partners. One such shared partner contains a COOH-terminal HECT-containing domain that interacts with an NH(2)-terminal degron domain in BRCA1. Which disease is associated with this specific shared partner via a biomarker relationship? | autism spectrum disorder | Medium | convergence | {"qa_id":"medium_convergence_01246","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRCA1 and BRCC3 share common interacting partners. One such shared partner contains a COOH-terminal HECT-containing domain that interacts with an NH(2)-termi... | |
medium_convergence_01247 | Both Human polyomavirus 1 and Zika virus are known to upregulate a specific gene. Experimental data for this gene, derived from renal epithelial cells in study GSE135833, reports a log2 fold change of approximately 1.29 and an adjusted p-value of approximately 0.019. Which disease is associated with this gene? | gastric cancer | Medium | convergence | {"qa_id":"medium_convergence_01247","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human polyomavirus 1 and Zika virus are known to upregulate a specific gene. Experimental data for this gene, derived from renal epithelial cells in stu... | |
medium_convergence_01248 | G3BP1 and EIF5 both interact with a shared protein entity. Experimental evidence indicates that eIF3 isolated from transfected cell lysates contains bound eIF5, suggesting a specific physical interaction between eIF5 and eIF3 that plays an important role in the function of eIF5 during translation initiation in eukaryot... | Eukaryotic translation initiation factor 3 subunit G | Medium | convergence | {"qa_id":"medium_convergence_01248","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"G3BP1 and EIF5 both interact with a shared protein entity. Experimental evidence indicates that eIF3 isolated from transfected cell lysates contains bound eI... | |
medium_convergence_01249 | EMD and HSPA8 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'We now report that emerin binds nuclear myosin I (a molecular motor) directly in vitro.' Which protein is connected to that entity through the 'encodes' relation? | Unconventional myosin-Ic | Medium | convergence | {"qa_id":"medium_convergence_01249","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EMD and HSPA8 each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'We now report that emerin binds nuclear m... | |
medium_convergence_01250 | CSNK2A1 and JAK3 both interact with a shared protein entity. Evidence regarding this entity states: 'We demonstrate that casein kinase 2 (CKII) from HeLa cell nuclear extracts interacts with immobilized NAP-II, and phosphorylates both NAP-2 and nucleosome assembly protein 1 (NAP-1) in vitro.' Which protein is encoded b... | Nucleosome assembly protein 1-like 4 | Medium | convergence | {"qa_id":"medium_convergence_01250","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2A1 and JAK3 both interact with a shared protein entity. Evidence regarding this entity states: 'We demonstrate that casein kinase 2 (CKII) from HeLa cel... | |
medium_convergence_01251 | PPP2CA and PPP2CB both interact with a specific protein. Evidence indicates that Protein phosphatase 2A (PP2A) constitutes a binding partner of human separase, although the functional relevance of this interaction has remained enigmatic. Which protein is encoded by the gene corresponding to this shared interaction part... | Separin | Medium | convergence | {"qa_id":"medium_convergence_01251","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PPP2CA and PPP2CB both interact with a specific protein. Evidence indicates that Protein phosphatase 2A (PP2A) constitutes a binding partner of human separas... | |
medium_convergence_01252 | GH1 and GHR each interact with more than one shared protein. Evidence concerning one shared entity reports that CIS and a suppressor of cytokine signaling protein bound to fusions containing as few as 80 COOH-terminal residues of the growth hormone receptor, provided the fusion protein was tyrosine-phosphorylated. Whic... | acute hemorrhagic leukoencephalitis | Medium | convergence | {"qa_id":"medium_convergence_01252","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GH1 and GHR each interact with more than one shared protein. Evidence concerning one shared entity reports that CIS and a suppressor of cytokine signaling pr... | |
medium_convergence_01253 | MAP2K1 and BAD share multiple binding partners. One shared partner was identified using the yeast two-hybrid system to search for BAD-binding proteins in an ovarian fusion cDNA library, where multiple cDNA clones encoding different isoforms of 14-3-3 were found. These 14-3-3 proteins are evolutionarily conserved and es... | bipolar disorder | Medium | convergence | {"qa_id":"medium_convergence_01253","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAP2K1 and BAD share multiple binding partners. One shared partner was identified using the yeast two-hybrid system to search for BAD-binding proteins in an ... | |
medium_convergence_01254 | Both Human orthopneumovirus and Human immunodeficiency virus 1 are known to upregulate a specific shared gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 1.47 and an adjusted p-value of 0.023. Which cellular component is this gene produc... | extracellular space | Medium | convergence | {"qa_id":"medium_convergence_01254","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human orthopneumovirus and Human immunodeficiency virus 1 are known to upregulate a specific shared gene. Experimental data for this gene in cytotoxic T... | |
medium_convergence_01255 | CASP8 and IKBKG both interact with a common protein. Evidence indicates that knockdown of TRIM14 disrupts the association between NF-κB essential modulator and this shared protein, thereby attenuating the antiviral response. Which disease is associated with this protein as a biomarker? | breast carcinoma | Medium | convergence | {"qa_id":"medium_convergence_01255","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CASP8 and IKBKG both interact with a common protein. Evidence indicates that knockdown of TRIM14 disrupts the association between NF-κB essential modulator a... | |
medium_convergence_01256 | RNF139 and AMFR both interact with a shared protein. Contextual evidence indicates that this shared protein is INSIG, noting that TRC8 binds and stimulates the ubiquitylation of the endoplasmic reticulum anchor protein INSIG. Which gene encodes this shared protein? | Insulin-induced gene 1 protein | Medium | convergence | {"qa_id":"medium_convergence_01256","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RNF139 and AMFR both interact with a shared protein. Contextual evidence indicates that this shared protein is INSIG, noting that TRC8 binds and stimulates t... | |
medium_convergence_01258 | Both Human alphaherpesvirus 3 and Zika virus are known to downregulate a specific gene. Experimental data from a melanoma cell line study (GSE136586) indicates that for one such shared target, the log2 fold change is -1.051 and the adjusted p-value is 5.581e-07. Which disease is associated with this specific gene as a ... | colorectal carcinoma | Medium | convergence | {"qa_id":"medium_convergence_01258","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Zika virus are known to downregulate a specific gene. Experimental data from a melanoma cell line study (GSE136586) indicat... | |
medium_convergence_01259 | Both Human respirovirus 3 and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental data from a non-small cell lung adenocarcinoma cell line (study GSE147507) indicates that this gene exhibits a log2 fold change of approximately 1.49 and an adjusted ... | Stimulator of interferon genes protein | Medium | convergence | {"qa_id":"medium_convergence_01259","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human respirovirus 3 and Severe acute respiratory syndrome-related coronavirus are associated with the upregulation of a specific gene. Experimental dat... | |
medium_convergence_01260 | Human respirovirus 3 and Influenza A virus both upregulate a specific gene. Experimental data from a non-small cell lung adenocarcinoma cell line (study GSE147507) indicates that this gene has a log2 fold change of approximately 1.667 and an adjusted p-value of 0.04542. Which protein does this gene product bind to? | GCHFR | Medium | convergence | {"qa_id":"medium_convergence_01260","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human respirovirus 3 and Influenza A virus both upregulate a specific gene. Experimental data from a non-small cell lung adenocarcinoma cell line (study GSE1... | |
medium_convergence_01261 | Hepacivirus C and Rhinovirus A both downregulate a specific gene. Evidence for this shared target reports a log2 fold change of -1.641 and an adjusted p-value of 0.01952. Which disease is connected to that gene through genomic alterations? | major affective disorder 9 | Medium | convergence | {"qa_id":"medium_convergence_01261","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hepacivirus C and Rhinovirus A both downregulate a specific gene. Evidence for this shared target reports a log2 fold change of -1.641 and an adjusted p-valu... | |
medium_convergence_01263 | PRKCZ and RIPK1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'The present data show that the shared entity and PAR-4 do not compete for PKCzeta binding but directly interact each other and form a ternary complex with PKCzeta.' Which protein is connected to that entity ... | Sequestosome-1 | Medium | convergence | {"qa_id":"medium_convergence_01263","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKCZ and RIPK1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'The present data show that the shared entity... | |
medium_convergence_01264 | CBX3 and MEN1 both interact with a specific shared protein. Experimental evidence for this interaction includes yeast two-hybrid and in vitro binding assays demonstrating that the human LR domain binds to heterochromatin protein 1 (HP1). Which protein is encoded by this shared interacting partner? | Proliferation marker protein Ki-67 | Medium | convergence | {"qa_id":"medium_convergence_01264","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBX3 and MEN1 both interact with a specific shared protein. Experimental evidence for this interaction includes yeast two-hybrid and in vitro binding assays ... | |
medium_convergence_01265 | HSP90AA1 and UBR5 both interact with a specific shared protein. Evidence indicates that this shared protein associates with an E3 ligase complex containing EDD, DDB1, and VPRBP proteins (the EDVP complex). Which protein is encoded by the gene corresponding to this shared entity? | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | Medium | convergence | {"qa_id":"medium_convergence_01265","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSP90AA1 and UBR5 both interact with a specific shared protein. Evidence indicates that this shared protein associates with an E3 ligase complex containing E... | |
medium_convergence_01266 | CTBP1 and RBBP4 both interact with a shared protein. Evidence regarding one such shared partner states: 'In this study, we show by coimmunoprecipitation that a zinc finger E-box-binding homeobox protein and CtBP interact in vivo and that an isolated CtBP-binding fragment of this protein depends on CtBP for transcriptio... | Zinc finger E-box-binding homeobox 2 | Medium | convergence | {"qa_id":"medium_convergence_01266","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTBP1 and RBBP4 both interact with a shared protein. Evidence regarding one such shared partner states: 'In this study, we show by coimmunoprecipitation that... | |
medium_convergence_01267 | DDB1 and DNMT1 share interaction partners. One such shared partner is described in the context: 'Here, we show that the human de novo enzymes hDNMT3a and hDNMT3b form complexes with the major maintenance enzyme hDNMT1.' Based on this evidence, which protein corresponds to the shared entity mentioned, and what is the na... | DNA (cytosine-5)-methyltransferase 3A | Medium | convergence | {"qa_id":"medium_convergence_01267","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DDB1 and DNMT1 share interaction partners. One such shared partner is described in the context: 'Here, we show that the human de novo enzymes hDNMT3a and hDN... | |
medium_convergence_01268 | HUWE1 and PRKN (PARK2) share common interaction partners. One such shared partner is characterized by evidence stating: 'Cell-based assays demonstrated that HUWE1 interacts with and regulates ubiquitination and stability of this entity.' Identify the gene that interacts with this specific shared partner. | CUL4A | Medium | convergence | {"qa_id":"medium_convergence_01268","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HUWE1 and PRKN (PARK2) share common interaction partners. One such shared partner is characterized by evidence stating: 'Cell-based assays demonstrated that ... | |
medium_convergence_01269 | CRK and BIN1 each interact with more than one shared protein. Evidence concerning one of these shared entities reports that it was capable of interacting via its Pro-rich domain with amphiphysin II, which contains an SH3 domain and participates in receptor-mediated endocytosis. Which protein is connected to that entity... | Ras and Rab interactor 3 | Medium | convergence | {"qa_id":"medium_convergence_01269","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRK and BIN1 each interact with more than one shared protein. Evidence concerning one of these shared entities reports that it was capable of interacting via... | |
medium_convergence_01270 | DCTN1 and MYC both interact with a shared gene. Evidence indicates that upregulation of this shared entity increases its binding with c-Myc and activates c-Myc, which in turn induces the expression of CCND1/CDK4, promoting glioma cell temozolomide resistance and proliferation. Which disease is connected to this entity ... | depressive disorder | Medium | convergence | {"qa_id":"medium_convergence_01270","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DCTN1 and MYC both interact with a shared gene. Evidence indicates that upregulation of this shared entity increases its binding with c-Myc and activates c-M... | |
medium_convergence_01271 | MLLT4 and APBB1IP share common binding partners. One such shared partner is implicated in evidence stating: 'We further demonstrate that both Ras and Rap1 interact with full-length AF-6 in vivo in mammalian cells and that a fraction of Rap1 colocalizes with AF-6 at the membrane.' Which protein is encoded by the gene co... | Ras-related protein Rap-1A | Medium | convergence | {"qa_id":"medium_convergence_01271","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MLLT4 and APBB1IP share common binding partners. One such shared partner is implicated in evidence stating: 'We further demonstrate that both Ras and Rap1 in... | |
medium_convergence_01272 | EHMT2 and CTBP1 both interact with a shared protein. Evidence for this shared protein states: 'Strikingly, we found that the protein binds to both SUV39H1 and G9A histone methyl transferases, which provides a direct link between histone methylation and the protein at heterochromatic and euchromatic sites.' Which protei... | Zinc finger protein Gfi-1b | Medium | convergence | {"qa_id":"medium_convergence_01272","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EHMT2 and CTBP1 both interact with a shared protein. Evidence for this shared protein states: 'Strikingly, we found that the protein binds to both SUV39H1 an... | |
medium_convergence_01274 | BIRC2 and XIAP both interact with a shared gene product. Contextual evidence indicates that this shared entity, along with cIAP1, is localized on midbody microtubules at telophase and interacts with cIAP1 during mitosis. Which disease is associated with this entity through genomic alterations? | asthma | Medium | convergence | {"qa_id":"medium_convergence_01274","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BIRC2 and XIAP both interact with a shared gene product. Contextual evidence indicates that this shared entity, along with cIAP1, is localized on midbody mic... | |
medium_convergence_01275 | CREBBP and KMT2C both interact with a specific shared protein. Evidence regarding this interaction notes that AD2 and AD3 served as binding sites for CREB binding protein (CBP), and that CBP-neutralizing E1A repressed the autonomous transactivation function of ASC-2. Which protein is encoded by the gene corresponding t... | Nuclear receptor coactivator 6 | Medium | convergence | {"qa_id":"medium_convergence_01275","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and KMT2C both interact with a specific shared protein. Evidence regarding this interaction notes that AD2 and AD3 served as binding sites for CREB bi... | |
medium_convergence_01276 | GRB7 and IGF1R both interact with a shared protein. Evidence indicates that this shared protein binds to insulin receptors when they are activated and tyrosine phosphorylated. Which protein is encoded by the gene corresponding to this shared entity? | Insulin receptor | Medium | convergence | {"qa_id":"medium_convergence_01276","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRB7 and IGF1R both interact with a shared protein. Evidence indicates that this shared protein binds to insulin receptors when they are activated and tyrosi... | |
medium_convergence_01277 | HIST1H2BG and H3C1 share interaction partners. One such shared partner is experimentally identified as an interaction partner of histone H3 trimethylated on lysine 9 (H3K9me3). Which protein is encoded by this specific shared partner? | Chromodomain Y-like protein | Medium | convergence | {"qa_id":"medium_convergence_01277","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HIST1H2BG and H3C1 share interaction partners. One such shared partner is experimentally identified as an interaction partner of histone H3 trimethylated on ... | |
medium_convergence_01278 | Both NEDD4L and NEDD4 interact with a common gene product. Evidence for one such shared partner states that this protein interacts with the ubiquitin ligase NEDD4 through two conserved PPXY motifs and recruits NEDD4 to the activated receptor. Which gene is connected to this specific shared partner via an 'interacts wit... | ITCH | Medium | convergence | {"qa_id":"medium_convergence_01278","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both NEDD4L and NEDD4 interact with a common gene product. Evidence for one such shared partner states that this protein interacts with the ubiquitin ligase ... | |
medium_convergence_01279 | PARP1 and SIRT1 share a common interacting partner. Evidence indicates that DNA damage provokes the interaction between this shared partner and SIRT1, resulting in the phosphorylation of SIRT1 at Serine 682 upon lethal damage. Which protein is encoded by this shared interacting partner? | Homeodomain-interacting protein kinase 2 | Medium | convergence | {"qa_id":"medium_convergence_01279","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and SIRT1 share a common interacting partner. Evidence indicates that DNA damage provokes the interaction between this shared partner and SIRT1, result... | |
medium_convergence_01280 | DIS3 and EXOSC7 both interact with a shared protein complex component. Evidence regarding one such shared entity states: 'Here, we demonstrate the association of two different Dis3p homologs--hDIS3 and hDIS3L--with the human exosome core.' Which disease is associated with this specific shared entity through genomic alt... | pontocerebellar hypoplasia, type 1C | Medium | convergence | {"qa_id":"medium_convergence_01280","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DIS3 and EXOSC7 both interact with a shared protein complex component. Evidence regarding one such shared entity states: 'Here, we demonstrate the associatio... | |
medium_convergence_01282 | Both the intervertebral disk of the thoracic vertebra and the thoracic vertebra endochondral element are classified as types of a specific anatomical entity. Evidence regarding this shared entity states: 'An intervertebral disk that is part of a thoracic region of vertebral column. A thoracic intervertebral disk connec... | dorsum | Medium | convergence | {"qa_id":"medium_convergence_01282","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both the intervertebral disk of the thoracic vertebra and the thoracic vertebra endochondral element are classified as types of a specific anatomical entity.... | |
medium_convergence_01283 | ERCC1 and CENPS share multiple binding partners. One shared partner forms a complex with ERCC1 through a direct interaction between their binding domains, a mechanism essential for nucleotide excision repair. Which cell type is enriched for this shared partner? | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_01283","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERCC1 and CENPS share multiple binding partners. One shared partner forms a complex with ERCC1 through a direct interaction between their binding domains, a ... | |
medium_convergence_01285 | SIN3A and ZBTB16 both interact with a shared protein entity. Contextual evidence indicates that the interaction between this entity and transcription factors can be disrupted by phosphorylation via RTK pathway activation. Which protein is encoded by this shared entity? | Nuclear receptor corepressor 2 | Medium | convergence | {"qa_id":"medium_convergence_01285","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SIN3A and ZBTB16 both interact with a shared protein entity. Contextual evidence indicates that the interaction between this entity and transcription factors... | |
medium_convergence_01286 | EZH2 and SIRT1 share common interaction partners. One such shared partner physically binds to EZH2 both in vitro and in vivo; EZH2 is a component of the Polycomb repressive complex 2 required to repress CLU. Which protein is encoded by this shared partner? | N-myc proto-oncogene protein | Medium | convergence | {"qa_id":"medium_convergence_01286","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EZH2 and SIRT1 share common interaction partners. One such shared partner physically binds to EZH2 both in vitro and in vivo; EZH2 is a component of the Poly... | |
medium_convergence_01287 | NFIB and RNF2 both interact with a shared protein. Evidence indicates that this shared protein interacts with Ring1B and Nspc1 to form a noncanonical PRC1 complex required for H2AK119ub1 in mouse ESCs. Which protein is encoded by this shared entity? | Lysine-specific demethylase 2B | Medium | convergence | {"qa_id":"medium_convergence_01287","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NFIB and RNF2 both interact with a shared protein. Evidence indicates that this shared protein interacts with Ring1B and Nspc1 to form a noncanonical PRC1 co... | |
medium_convergence_01288 | AKT1 and ESR1 share multiple interacting partners. One such shared partner is identified as a direct interacting protein of AKT1, where it strongly binds the N-terminal region of AKT1 to block its K63-linked poly-ubiquitination and subsequent activation. This shared partner is also known as XIAP-associated factor. Whic... | XIAP-associated factor 1 | Medium | convergence | {"qa_id":"medium_convergence_01288","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKT1 and ESR1 share multiple interacting partners. One such shared partner is identified as a direct interacting protein of AKT1, where it strongly binds the... | |
medium_convergence_01289 | MDM2 and ACE2 share common interaction partners. One such shared partner is described as interacting with MDM2 at its central acidic domain, thereby suppressing MDM2-mediated p53 ubiquitination and leading to p53 activation and cell cycle arrest. Which disease is associated with this specific shared partner? | gastric cancer | Medium | convergence | {"qa_id":"medium_convergence_01289","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MDM2 and ACE2 share common interaction partners. One such shared partner is described as interacting with MDM2 at its central acidic domain, thereby suppress... | |
medium_convergence_01290 | DLG1 and DLG4 both interact with a specific shared protein. Evidence regarding this shared entity states: 'We report a novel protein, which is highly conserved from mammals to plants and binds selectively to the third PDZ domain (PDZ3) of PSD-95 via its C terminus.' Which protein is encoded by this shared entity? | Cysteine-rich PDZ-binding protein | Medium | convergence | {"qa_id":"medium_convergence_01290","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLG1 and DLG4 both interact with a specific shared protein. Evidence regarding this shared entity states: 'We report a novel protein, which is highly conserv... | |
medium_convergence_01292 | PARP1 and GTF2H3 both interact with a specific protein. Evidence indicates that this protein forms a stable complex with the shared interaction partner in the nucleoplasm under steady-state conditions before irradiation and rapidly escorts it to damaged DNA after UV irradiation in a DDB2-independent manner. Which prote... | DNA repair protein complementing XP-C cells | Medium | convergence | {"qa_id":"medium_convergence_01292","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and GTF2H3 both interact with a specific protein. Evidence indicates that this protein forms a stable complex with the shared interaction partner in th... | |
medium_convergence_01293 | Human alphaherpesvirus 1 and Hepacivirus C both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) shows a log2 fold change of -1.529 and an adjusted p-value of 0.002615. Which disease is associated with this gene? | acute myeloid leukemia | Medium | convergence | {"qa_id":"medium_convergence_01293","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Hepacivirus C both downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114... | |
medium_convergence_01294 | Both Orthohepevirus A and Primate bocaparvovirus 1 are associated with the downregulation of a specific gene. Experimental data for this gene in hepatocytes (from study GSE135619) reports a log2 fold change of -1.458 and an adjusted p-value of 0.04531. Which protein is encoded by this gene? | Coiled-coil domain-containing protein 24 | Medium | convergence | {"qa_id":"medium_convergence_01294","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Orthohepevirus A and Primate bocaparvovirus 1 are associated with the downregulation of a specific gene. Experimental data for this gene in hepatocytes ... | |
medium_convergence_01295 | ARPC2 and CBL both interact with a specific shared protein. Experimental evidence indicates that the NTA region of this shared protein interacts directly with the Arp2/3 complex, as demonstrated by affinity chromatography, immunoprecipitation assays, and binding assays using purified components. Which protein is encode... | Src substrate cortactin | Medium | convergence | {"qa_id":"medium_convergence_01295","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARPC2 and CBL both interact with a specific shared protein. Experimental evidence indicates that the NTA region of this shared protein interacts directly wit... | |
medium_convergence_01296 | Both Measles morbillivirus and Human orthopneumovirus are associated with the upregulation of a specific gene. Experimental data for this gene in pleural mesothelioma cells (study GSE117668) reports a log2 fold change of approximately 1.956 and an adjusted p-value of 0.001612. What molecular function is enabled by this... | protein binding | Medium | convergence | {"qa_id":"medium_convergence_01296","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Human orthopneumovirus are associated with the upregulation of a specific gene. Experimental data for this gene in pleural mes... | |
medium_convergence_01297 | YAP1 and BAIAP2 both interact with a common protein partner. Evidence indicates that this partner binds to YAP1 and mediates the ubiquitination and degradation of YAP1. Which protein is encoded by the gene corresponding to this partner? | E3 ubiquitin-protein ligase NEDD4-like | Medium | convergence | {"qa_id":"medium_convergence_01297","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and BAIAP2 both interact with a common protein partner. Evidence indicates that this partner binds to YAP1 and mediates the ubiquitination and degradati... | |
medium_convergence_01298 | SMAD6 and CAV1 both interact with a common protein partner. Experimental evidence regarding this partner states: 'We carried out docking of the WW2 domain of this partner with the PPXY motifs of Smad1, Smad5, and Smad6 and identified the key amino acid residues involved in interaction.' Which protein is encoded by this... | E3 ubiquitin-protein ligase SMURF1 | Medium | convergence | {"qa_id":"medium_convergence_01298","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD6 and CAV1 both interact with a common protein partner. Experimental evidence regarding this partner states: 'We carried out docking of the WW2 domain of... | |
medium_convergence_01299 | KDM6A and HIST1H4A share common interaction partners. One such partner is the subject of evidence stating: 'The solution NMR structure of MLL4-PHD6 in complex with a H4K16ac peptide along with binding and mutational analyses reveal unique mechanistic features underlying recognition of H4K16ac.' Which protein encodes th... | Histone-lysine N-methyltransferase 2C | Medium | convergence | {"qa_id":"medium_convergence_01299","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KDM6A and HIST1H4A share common interaction partners. One such partner is the subject of evidence stating: 'The solution NMR structure of MLL4-PHD6 in comple... | |
medium_convergence_01300 | MCL1 and BCL2L2 each interact with more than one shared protein. Evidence concerning one such shared entity reports that Bcl-w co-immunoprecipitated from cell lysates with Bax, Bak, Bad, and this protein, whereas A1 bound only Bak and this protein. Which protein is encoded by the gene corresponding to that entity? | Bcl-2-interacting killer | Medium | convergence | {"qa_id":"medium_convergence_01300","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MCL1 and BCL2L2 each interact with more than one shared protein. Evidence concerning one such shared entity reports that Bcl-w co-immunoprecipitated from cel... | |
medium_convergence_01301 | MCM3 and MCM6 share a common interacting partner. Evidence regarding this partner states: 'Here we show that human [the protein encoded by the gene corresponding to this shared interacting partner] is capable of interacting with individual MCM proteins 2 through 7 when co-expressed in insect cells and can greatly incre... | Mini-chromosome maintenance complex-binding protein | Medium | convergence | {"qa_id":"medium_convergence_01301","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MCM3 and MCM6 share a common interacting partner. Evidence regarding this partner states: 'Here we show that human [the protein encoded by the gene correspon... | |
medium_convergence_01302 | ANAPC10 and ANAPC11 both interact with a specific shared protein partner. Evidence indicates that this partner is a cullin-related subunit, noting that 'Both APC11 and UbcH10 bind to the C-terminal cullin homology domain of this subunit, whereas Ubc4 interacts with APC11 directly.' In which cellular component is this s... | anaphase-promoting complex | Medium | convergence | {"qa_id":"medium_convergence_01302","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC10 and ANAPC11 both interact with a specific shared protein partner. Evidence indicates that this partner is a cullin-related subunit, noting that 'Both... | |
medium_convergence_01303 | DLGAP4 and GRM5 both interact with a shared protein partner. Experimental evidence regarding this partner states: 'Using the PDZ domains of ProSAP1 and 2 as bait in the yeast two-hybrid system, we isolated several clones of the SAPAP/GKAP (SAP90/PSD-95-associated protein/guanylate kinase-associated protein) family.' Wh... | SH3 and multiple ankyrin repeat domains protein 3 | Medium | convergence | {"qa_id":"medium_convergence_01303","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLGAP4 and GRM5 both interact with a shared protein partner. Experimental evidence regarding this partner states: 'Using the PDZ domains of ProSAP1 and 2 as ... | |
medium_convergence_01304 | IGF1 and IGF2 both bind to a specific shared protein partner. Evidence indicates that this partner, when occupied by IGF-I or IGF-II, forms ternary complexes of approximately 130 kDa with the acid-labile subunit. Which disease is associated with this protein through genomic alterations? | breast cancer | Medium | convergence | {"qa_id":"medium_convergence_01304","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IGF1 and IGF2 both bind to a specific shared protein partner. Evidence indicates that this partner, when occupied by IGF-I or IGF-II, forms ternary complexes... | |
medium_convergence_01305 | KAT5 and HDAC1 both interact with a specific shared protein. Evidence indicates that Tip60 physically interacts with this shared protein via its chromo- and Zn-finger-containing region, and that this interaction is required for the effective transcriptional activation of this shared protein. Which protein is encoded by... | Myoblast determination protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01305","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KAT5 and HDAC1 both interact with a specific shared protein. Evidence indicates that Tip60 physically interacts with this shared protein via its chromo- and ... | |
medium_convergence_01306 | PNKP and XRCC4 both interact with a shared protein partner. Evidence indicates that the SCF(FBXW7) E3 ligase promotes the polyubiquitylation of this shared entity at lysine 296 via lysine 63 linkage, thereby enhancing its association with the Ku70/80 complex to facilitate non-homologous end joining (NHEJ) repair. Which... | DNA repair protein Ku80 | Medium | convergence | {"qa_id":"medium_convergence_01306","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PNKP and XRCC4 both interact with a shared protein partner. Evidence indicates that the SCF(FBXW7) E3 ligase promotes the polyubiquitylation of this shared e... | |
medium_convergence_01307 | HGF and MET each interact with more than one shared protein. Evidence concerning one shared entity states: 'We show that, like RanBPM/RanBP9, this entity interacts with the tyrosine kinase domain of MET via its SPRY domain and these two proteins can compete with each other to bind to MET.' Which molecular function is e... | protein binding | Medium | convergence | {"qa_id":"medium_convergence_01307","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HGF and MET each interact with more than one shared protein. Evidence concerning one shared entity states: 'We show that, like RanBPM/RanBP9, this entity int... | |
medium_convergence_01308 | VPS28 and UBC share multiple binding partners. One such partner is a component of the ESCRT-II complex that binds to the C-terminal domain of the ESCRT-I subunit VPS28 via a helix located immediately C-terminal to its GLUE domain. Which disease is associated with this specific ESCRT-II component? | lipoma | Medium | convergence | {"qa_id":"medium_convergence_01308","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"VPS28 and UBC share multiple binding partners. One such partner is a component of the ESCRT-II complex that binds to the C-terminal domain of the ESCRT-I sub... | |
medium_convergence_01310 | UCHL5 and PSMD4 both interact with a shared protein. Evidence indicates that this shared protein is a human homolog of RAD23 (specifically the protein encoded by RAD23A) that interacts with S5a, a subunit of the human 26S proteasome. Which protein is encoded by this shared entity? | Lysine-specific demethylase RAD23A | Medium | convergence | {"qa_id":"medium_convergence_01310","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UCHL5 and PSMD4 both interact with a shared protein. Evidence indicates that this shared protein is a human homolog of RAD23 (specifically the protein encode... | |
medium_convergence_01312 | Hepacivirus C and Dengue virus both downregulate a specific gene. Experimental data for this gene shows a log2 fold change of -1.669 and an adjusted p-value of 0.001448. Which protein is encoded by this gene? | ATP-dependent DNA helicase PIF1 | Medium | convergence | {"qa_id":"medium_convergence_01312","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hepacivirus C and Dengue virus both downregulate a specific gene. Experimental data for this gene shows a log2 fold change of -1.669 and an adjusted p-value ... | |
medium_convergence_01313 | ANAPC13 and AURKB share multiple binding partners. One specific shared partner is characterized by evidence stating that Aurora-B interacts with the APC/C complex through this subunit, and that Aurora-B is ubiquitinated with its levels increasing upon proteasome inhibitor treatment. Which gene does this specific shared... | CDH1 | Medium | convergence | {"qa_id":"medium_convergence_01313","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC13 and AURKB share multiple binding partners. One specific shared partner is characterized by evidence stating that Aurora-B interacts with the APC/C co... | |
medium_convergence_01314 | Both Vaccinia virus and Enterovirus A are known to downregulate the expression of a specific host gene. In a study using a cervical adenocarcinoma cell line (GSE11238), evidence for one such shared target reports a log2 fold change of approximately -2.70 and an adjusted p-value of 0.012. Which biological process is thi... | negative regulation of transcription by RNA polymerase II | Medium | convergence | {"qa_id":"medium_convergence_01314","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Vaccinia virus and Enterovirus A are known to downregulate the expression of a specific host gene. In a study using a cervical adenocarcinoma cell line ... | |
medium_convergence_01315 | Both Human alphaherpesvirus 1 and Rift Valley fever phlebovirus are known to upregulate a specific shared gene. Experimental data for this gene, derived from a monocytic leukemia cell line (study GSE114966), reports a log2 fold change of approximately 1.615 and an adjusted p-value of 0.007018. In which cellular compone... | nucleus | Medium | convergence | {"qa_id":"medium_convergence_01315","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Rift Valley fever phlebovirus are known to upregulate a specific shared gene. Experimental data for this gene, derived from... | |
medium_convergence_01316 | Both CRYAA and CRYAB interact with a shared protein entity. Experimental evidence regarding this entity notes that Chloramphenicol acetyltransferase activity assays revealed interactions between alphaA- (or alphaB-) and betaB2- or gammaC-crystallins, with an intensity one-third that of alphaA-alphaB interactions. Which... | visual perception | Medium | convergence | {"qa_id":"medium_convergence_01316","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both CRYAA and CRYAB interact with a shared protein entity. Experimental evidence regarding this entity notes that Chloramphenicol acetyltransferase activity... |
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