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medium_divergent_branch_03745 | FBXO28 interacts with multiple genes. One of these interaction partners is directly bound by FBXO28, which functions as an E3 ubiquitin ligase targeting this partner for degradation via the ubiquitin-proteasome system. Which disease is associated with this specific interaction partner through genomic alterations? | piebaldism | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03745","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBXO28 interacts with multiple genes. One of these interaction partners is directly bound by FBXO28, which functions as an E3 ubiquitin ligase target... | |
medium_divergent_branch_03747 | Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.616 and an adjusted p-value of 0.0476. Which protein does that selected gene encode? | Protein furry homolog | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03747","source_qa_id":"medium_divergent_branch_02257","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showe... | |
medium_divergent_branch_03748 | ASB11 interacts with multiple genes. One interaction is supported by evidence stating: 'We also demonstrated that ASB11 is a novel endoplasmic reticulum-associated ubiquitin ligase with the ability to interact and promote the ubiquitination of Ribophorin 1, an integral protein of the oligosaccharyltransferase (OST) gly... | protein N-linked glycosylation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03748","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ASB11 interacts with multiple genes. One interaction is supported by evidence stating: 'We also demonstrated that ASB11 is a novel endoplasmic reticu... | |
medium_divergent_branch_03749 | UFL1 interacts with multiple proteins. One interaction partner facilitates the recruitment of the UFL1 ligase to the endoplasmic reticulum (ER) surface to UFMylate RPN1 and RPL26, preferentially targeting ER sheets for degradation in a manner analogous to PINK1-Parkin regulation during mitophagy. Which protein, connect... | DDRGK domain-containing protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03749","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UFL1 interacts with multiple proteins. One interaction partner facilitates the recruitment of the UFL1 ligase to the endoplasmic reticulum (ER) surfa... | |
medium_divergent_branch_03750 | UBE2E2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Our studies identified four different E2 conjugating enzymes (UBE2E2, Ube2E3, Ube2G2 and Ube2L3) as specific interactors of Mulan.' Based on this clue, identify the gene that interacts with UBE2E2 and is described in this ... | endoplasmic reticulum | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03750","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBE2E2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Our studies identified four different E2 conjugatin... | |
medium_divergent_branch_03751 | GPER1 is associated with multiple cellular components via 'located in' relationships. One specific association is supported by evidence stating: 'Staining of fixed and live cells showed that GPER1 was localized both in the PM and on intracellular structures.' Based on this evidence, which cellular component is the corr... | cell periphery | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03751","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GPER1 is associated with multiple cellular components via 'located in' relationships. One specific association is supported by evidence stating: 'Sta... | |
medium_divergent_branch_03752 | WNT2B is implicated in multiple biological processes. One line of evidence notes that a subset of genes, including WNT2B, WNT5B, WNT10B, FZD6, and FZD7, exhibited altered expression in human dermal fibroblasts (hDFs) exposed to DBP for 3 days. Which biological process, connected to the process supported by this evidenc... | cartilage development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03752","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WNT2B is implicated in multiple biological processes. One line of evidence notes that a subset of genes, including WNT2B, WNT5B, WNT10B, FZD6, and FZ... | |
medium_divergent_branch_03753 | Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -2.030 and an adjusted p-value of 0.0493. Which protein does that selected gene encode? | GTP-binding protein Di-Ras2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03753","source_qa_id":"medium_divergent_branch_06882","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showe... | |
medium_divergent_branch_03754 | HSF1 interacts with multiple genes. One interaction is supported by evidence stating: 'We show that activated HSF associates with hsp70 and that the interaction is detected as the levels of hsp70 increase in the cell.' Which cell type is enriched for the gene identified by this specific evidence? | naive B cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03754","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HSF1 interacts with multiple genes. One interaction is supported by evidence stating: 'We show that activated HSF associates with hsp70 and that the ... | |
medium_divergent_branch_03755 | CTNNA1 interacts with multiple genes. One specific interaction was identified through yeast two-hybrid screening of a human fetal brain cDNA library using p100 as bait, revealing a specific interaction with alpha-catenin, a known regulator of adherens junctions and actin cytoskeleton remodeling. Which disease is associ... | intellectual developmental disorder with short stature and behavioral abnormalities | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03755","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CTNNA1 interacts with multiple genes. One specific interaction was identified through yeast two-hybrid screening of a human fetal brain cDNA library ... | |
medium_divergent_branch_03756 | CDH1 interacts with multiple proteins. One of these interaction partners is described as a novel RasGAP-related protein that interacts with the cytoskeleton, binds to actin, members of the Rho family, and E-cadherin. Which protein corresponds to this description? | Ras GTPase-activating-like protein IQGAP1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03756","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDH1 interacts with multiple proteins. One of these interaction partners is described as a novel RasGAP-related protein that interacts with the cytos... | |
medium_divergent_branch_03757 | The biological process 'detection of mechanical stimulus involved in sensory perception of sound' is enabled by more than one cell type. One of these cell types is described as 'A specialized cell involved in auditory sensory perception.' Which parent class is this specific cell type a subclass of? | sensory epithelial cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03757","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The biological process 'detection of mechanical stimulus involved in sensory perception of sound' is enabled by more than one cell type. One of these... | |
medium_divergent_branch_03758 | HIPK2 interacts with multiple proteins. One of these interactions is characterized by the finding that either wild-type or E3-dead mutant forms of the interacting protein disrupt the formation of an Axin-based HIPK2/p53 complex by blocking the binding of p53 and HIPK2 to Axin. Which protein, connected to HIPK2 via an i... | Axin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03758","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HIPK2 interacts with multiple proteins. One of these interactions is characterized by the finding that either wild-type or E3-dead mutant forms of th... | |
medium_divergent_branch_03759 | HDAC7 interacts with multiple genes. One of these interactions is supported by evidence stating: 'We have identified alpha-actinin 1 and 4 as class IIa HDAC-interacting proteins.' Which disease is associated with the gene identified in this evidence via a biomarker relationship? | cerebellar hemangioblastoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03759","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HDAC7 interacts with multiple genes. One of these interactions is supported by evidence stating: 'We have identified alpha-actinin 1 and 4 as class I... | |
medium_divergent_branch_03761 | SERP1 interacts with multiple proteins. One specific interaction partner was identified through co-expression in HEK-293 cells and confirmed by co-immunoprecipitation. Which protein is encoded by the gene corresponding to this specific interaction partner? | Glucagon-like peptide 1 receptor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03761","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SERP1 interacts with multiple proteins. One specific interaction partner was identified through co-expression in HEK-293 cells and confirmed by co-im... | |
medium_divergent_branch_03763 | CYP3A4 interacts with multiple proteins. One specific interaction was confirmed by an overlay assay using a glutathione S-transferase-CYP3A4 fusion protein. Which protein, connected to CYP3A4 via this interaction, is encoded by the gene in question? | UDP-glucuronosyltransferase 2B7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03763","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CYP3A4 interacts with multiple proteins. One specific interaction was confirmed by an overlay assay using a glutathione S-transferase-CYP3A4 fusion p... | |
medium_divergent_branch_03764 | CCN3 is associated with multiple biological processes. One association is supported by evidence that CCN3 suppresses vascular smooth muscle cell (VSMC) proliferation induced by fetal bovine serum. Which biological process, connected to the process implicated by this evidence via an 'is a' relationship, is the correct t... | muscle cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03764","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CCN3 is associated with multiple biological processes. One association is supported by evidence that CCN3 suppresses vascular smooth muscle cell (VSM... | |
medium_divergent_branch_03765 | SMURF2 interacts with multiple genes. One of these interaction partners is part of a membrane-associated protein complex that also contains HER2 and SMURF2. Which disease is associated with this specific interaction partner via a biomarker relationship? | metabolic bone disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03765","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMURF2 interacts with multiple genes. One of these interaction partners is part of a membrane-associated protein complex that also contains HER2 and ... | |
medium_divergent_branch_03766 | TRIM22 interacts with multiple proteins. One specific interaction partner is described as being degraded by TRIM22 in a ubiquitination-dependent manner. Which protein product is encoded by this interaction partner? | Histone acetyltransferase KAT2A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03766","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM22 interacts with multiple proteins. One specific interaction partner is described as being degraded by TRIM22 in a ubiquitination-dependent mann... | |
medium_divergent_branch_03767 | CDK6 is implicated in multiple biological processes. One specific process is supported by evidence stating: 'We found that Cdk6 was essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles.' Which anatomical structure is the result of the develop... | dentate gyrus of hippocampal formation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03767","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDK6 is implicated in multiple biological processes. One specific process is supported by evidence stating: 'We found that Cdk6 was essential for cel... | |
medium_divergent_branch_03768 | RAD51C interacts with multiple proteins. Evidence for one specific interaction indicates that immunoprecipitation using protein-specific antibodies revealed RAD51C is central to a large protein complex (or several smaller ones) containing RAD51B, XRCC2, XRCC3, and the interacting partner. Which disease is associated wi... | colorectal carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03768","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAD51C interacts with multiple proteins. Evidence for one specific interaction indicates that immunoprecipitation using protein-specific antibodies r... | |
medium_divergent_branch_03769 | The Aryl hydrocarbon receptor (AHR) interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Co-immunoprecipitation and co-localization assays revealed that a nuclear receptor-interacting protein interacted with AHR, but not with ARNT, both in vitro and in cells.' Which protein, enc... | Nuclear receptor-interacting protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03769","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The Aryl hydrocarbon receptor (AHR) interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Co-immunoprecipitat... | |
medium_divergent_branch_03770 | PFKP interacts with multiple genes. One of these interaction partners is described by the following evidence: 'Phosphorylated PFKP binds to the N-terminal SH2 domain of the regulatory subunit of PI3K, which is distinct from binding of Gab1 to the C-terminal SH2 domain of the regulatory subunit of PI3K, and recruited th... | ovarian cyst | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03770","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PFKP interacts with multiple genes. One of these interaction partners is described by the following evidence: 'Phosphorylated PFKP binds to the N-ter... | |
medium_divergent_branch_03771 | ITPR3 interacts with multiple genes. One of these interaction partners is a component of the IP3R3-Grp75 complex at the mitochondria-associated endoplasmic reticulum membrane (MAM), where it physically interacts with DJ-1. Which disease is associated with this specific interaction partner? | amyloidosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03771","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ITPR3 interacts with multiple genes. One of these interaction partners is a component of the IP3R3-Grp75 complex at the mitochondria-associated endop... | |
medium_divergent_branch_03772 | EPHA2 interacts with multiple proteins. One specific interaction is described as indirect and mediated by SHC, forming a complex necessary for EPHA2-mediated activation of ERK kinases. Which protein, connected to EPHA2 via this interaction, is encoded by the gene in question? | Growth factor receptor-bound protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03772","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EPHA2 interacts with multiple proteins. One specific interaction is described as indirect and mediated by SHC, forming a complex necessary for EPHA2-... | |
medium_divergent_branch_03773 | MAP3K5 interacts with multiple genes. One of these interacting partners has been shown to interact with SUMO-1 both in vitro and in BOSC 23 cells. Which disease is associated with this specific interacting partner through genomic alterations? | osteosarcoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03773","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP3K5 interacts with multiple genes. One of these interacting partners has been shown to interact with SUMO-1 both in vitro and in BOSC 23 cells. Wh... | |
medium_divergent_branch_03774 | The gene WWC1 (also known as KIBRA) interacts with multiple proteins. One specific interaction is described by the evidence: 'In this report, we describe the identification of protein kinase C (PKC) zeta as a KIBRA-interacting protein.' Which disease is associated with the gene encoding this specific interacting protei... | adult acute lymphoblastic leukemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03774","source_qa_id":"medium_divergent_branch_03115","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene WWC1 (also known as KIBRA) interacts with multiple proteins. One specific interaction is... | |
medium_divergent_branch_03775 | AKR1C1 interacts with multiple genes. One of these interactions is supported by evidence stating that 'A reverse two-hybrid experiment and Co-IP indicated that ZNF193 and AKR1C1 might interact with the protein encoded by the gene connected to AKR1C1 in this interaction.' Which protein is encoded by the gene connected t... | Trefoil factor 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03775","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AKR1C1 interacts with multiple genes. One of these interactions is supported by evidence stating that 'A reverse two-hybrid experiment and Co-IP indi... | |
medium_divergent_branch_03776 | CEP55 interacts with multiple proteins. One interaction is characterized by evidence stating: 'We show here that CEP55 becomes a stable component of the intercellular bridge and that an evolutionarily conserved GPPX3Y motif of this protein binds strongly to CEP55 to block similar GPPX3Y motifs of ALIX and TSG101 from i... | Inactive serine/threonine-protein kinase TEX14 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03776","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CEP55 interacts with multiple proteins. One interaction is characterized by evidence stating: 'We show here that CEP55 becomes a stable component of ... | |
medium_divergent_branch_03777 | Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.687 and an adjusted p-value of 0.035. Which protein does that selected gene encode? | Ras-related protein Rab-3C | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03777","source_qa_id":"medium_divergent_branch_02865","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch sho... | |
medium_divergent_branch_03778 | The gene AJUBA interacts with multiple partners. One interaction is supported by evidence stating: 'We show that Ajuba interacts with Aurora B and BUBR1 [BUB (budding uninhibited by benomyl)-related 1], two major components of the mitotic checkpoint.' Which protein is encoded by the gene that interacts with AJUBA in th... | Aurora kinase B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03778","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene AJUBA interacts with multiple partners. One interaction is supported by evidence stating: 'We show that Ajuba interacts with Aurora B and BU... | |
medium_divergent_branch_03779 | CLNS1A interacts with multiple genes. One specific interaction is supported by evidence showing that ICln co-immunoprecipitates with alpha(IIb)beta(3) in platelet lysates, demonstrating physiological relevance. Which disease is associated with the gene involved in this specific interaction through genomic alterations? | Glanzmann thrombasthenia 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03779","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CLNS1A interacts with multiple genes. One specific interaction is supported by evidence showing that ICln co-immunoprecipitates with alpha(IIb)beta(3... | |
medium_divergent_branch_03780 | ANXA3 is associated with multiple biological processes. One of these processes is supported by evidence describing ANXA3 as a novel angiogenic factor that induces VEGF production through the HIF-1 pathway. Which cell type is linked to this specific biological process via the 'enabled by cell' relationship? | circulating fibrocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03780","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ANXA3 is associated with multiple biological processes. One of these processes is supported by evidence describing ANXA3 as a novel angiogenic factor... | |
medium_divergent_branch_03781 | The UBD domain interacts with multiple proteins. One interaction partner is characterized by evidence showing that FAT10 non-covalently associates with its 2CARD domain, thereby inhibiting viral RNA-induced IRF3 and NF-kB activation by modulating the protein's solubility. Which gene encodes this specific interaction pa... | Antiviral innate immune response receptor RIG-I | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03781","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The UBD domain interacts with multiple proteins. One interaction partner is characterized by evidence showing that FAT10 non-covalently associates wi... | |
medium_divergent_branch_03782 | The gene ATP6AP2 is associated with multiple biological processes. One association is supported by the statement: 'We conclude that ATP6AP2 is a key mediator of V-ATPase-dependent signaling and protein degradation in the developing human central nervous system.' Which biological process, connected to the process suppor... | central nervous system development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03782","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ATP6AP2 is associated with multiple biological processes. One association is supported by the statement: 'We conclude that ATP6AP2 is a key ... | |
medium_divergent_branch_03783 | WNT2B is implicated in multiple biological processes. One line of evidence indicates that Wnt2b is expressed in the anterior epithelium of the lens. Based on this tissue-specific expression context, which biological process involving WNT2B is a component of a broader developmental program? | camera-type eye development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03783","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WNT2B is implicated in multiple biological processes. One line of evidence indicates that Wnt2b is expressed in the anterior epithelium of the lens. ... | |
medium_divergent_branch_03785 | hsa-let-7b-5p regulates more than one cell type. Evidence for one of these regulatory connections notes that down-regulation of let-7 miRNAs in cultured adult CD34(+) cells or over-expression of LIN28 in cultured erythrocytes from pediatric patients with HbSS genotype causes increased levels of fetal hemoglobin (HbF) i... | reticulocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03785","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"hsa-let-7b-5p regulates more than one cell type. Evidence for one of these regulatory connections notes that down-regulation of let-7 miRNAs in cultu... | |
medium_divergent_branch_03786 | KLHL3 interacts with multiple genes. One specific interaction is characterized by evidence stating: 'Here, we found that KLHL3 interacted with Cullin3 and this partner, induced this partner's ubiquitination, and reduced this partner's protein level.' Which disease is connected to this specific interacting gene through ... | pseudohypoaldosteronism | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03786","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KLHL3 interacts with multiple genes. One specific interaction is characterized by evidence stating: 'Here, we found that KLHL3 interacted with Cullin... | |
medium_divergent_branch_03787 | IGF2BP2 interacts with multiple genes. One specific interaction is mechanistically described as follows: circNDUFB2 functions as a scaffold to enhance the interaction between this gene and IGF2BPs, which are positive regulators of tumor progression and metastasis. Which disease is associated with this gene via a biomar... | mammary neoplasms, animal | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03787","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IGF2BP2 interacts with multiple genes. One specific interaction is mechanistically described as follows: circNDUFB2 functions as a scaffold to enhanc... | |
medium_divergent_branch_03788 | ANK2 is associated with multiple biological processes. One specific association is supported by evidence stating: 'These data identify ANK2 variants as modulators of human arrhythmias, provide the first insight into the clinical spectrum of 'ankyrin-B syndrome,' and reinforce the role of ankyrin-B-dependent protein int... | regular atrial cardiac myocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03788","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ANK2 is associated with multiple biological processes. One specific association is supported by evidence stating: 'These data identify ANK2 variants ... | |
medium_divergent_branch_03789 | The protein CHP1 is associated with multiple molecular functions. One specific function is supported by evidence stating: 'We found that (45)Ca(2+) binds to two EF-hand motifs (EF3 and 4) of the recombinant CHP1 proteins with high affinity (apparent K(d) = approximately 90 nM).' Identify the parent molecular function (... | metal ion binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03789","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein CHP1 is associated with multiple molecular functions. One specific function is supported by evidence stating: 'We found that (45)Ca(2+) b... | |
medium_divergent_branch_03790 | TOPORS interacts with multiple genes. One of these interacting partners localizes to the nucleus in a punctate pattern when expressed as a green fluorescent protein fusion in HeLa cells and co-immunoprecipitates with topoisomerase I. Which disease is associated with this specific interacting gene through genomic altera... | adult medulloblastoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03790","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TOPORS interacts with multiple genes. One of these interacting partners localizes to the nucleus in a punctate pattern when expressed as a green fluo... | |
medium_divergent_branch_03792 | The COL3A1 gene is associated with multiple biological processes. One specific association is supported by evidence stating: 'These findings indicate that mutations in the COL3A1 gene have effects on secretion, fibrillogenesis, and skin architecture that reflect the position and nature of the mutation.' Which anatomica... | skin of body | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03792","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The COL3A1 gene is associated with multiple biological processes. One specific association is supported by evidence stating: 'These findings indicate... | |
medium_divergent_branch_03793 | PIM1 interacts with multiple proteins. One interaction is characterized by the finding that Pim-1 expression increases the level of the target protein through direct binding and phosphorylation of multiple sites on that protein. Which protein, encoded by the gene connected to PIM1 via this specific interaction, is the ... | S-phase kinase-associated protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03793","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PIM1 interacts with multiple proteins. One interaction is characterized by the finding that Pim-1 expression increases the level of the target protei... | |
medium_divergent_branch_03794 | The gene CBLC interacts with multiple partners. One interaction is supported by evidence stating: 'In this study we identify a new Cbl-c interacting protein, [Hydrogen peroxide Induced Construct 5].' Which cell type is enriched in the gene corresponding to this specific interaction? | basophil | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03794","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CBLC interacts with multiple partners. One interaction is supported by evidence stating: 'In this study we identify a new Cbl-c interacting ... | |
medium_divergent_branch_03795 | FBXO27 interacts with multiple proteins. One interaction partner is supported by evidence stating that all FBA proteins co-precipitated components of the canonical SCF complex (including Cullin1 and this partner), yet FBXO2 bound very little Cullin1, suggesting that FBXO2 may exist primarily as a heterodimer with this ... | S-phase kinase-associated protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03795","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBXO27 interacts with multiple proteins. One interaction partner is supported by evidence stating that all FBA proteins co-precipitated components of... | |
medium_divergent_branch_03796 | The gene EIF2AK3 is associated with multiple biological processes. One association is supported by evidence describing PEK (also known as PERK) as a transmembrane protein involved in translational control in response to endoplasmic reticulum stress. Which biological process, connected to this specific EIF2AK3-associate... | negative regulation of translational initiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03796","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene EIF2AK3 is associated with multiple biological processes. One association is supported by evidence describing PEK (also known as PERK) as a ... | |
medium_divergent_branch_03797 | GGA3 interacts with multiple proteins. One interaction is supported by evidence stating: 'A family of three structurally related proteins were cloned from human cDNA libraries by their ability to interact preferentially with the activated form of a human ADP-ribosylation factor in two-hybrid assays.' Which biological p... | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03797","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GGA3 interacts with multiple proteins. One interaction is supported by evidence stating: 'A family of three structurally related proteins were cloned... | |
medium_divergent_branch_03798 | MTA1 interacts with multiple genes. Evidence for one specific interaction indicates that the resulting complex contains HDAC1/2, RbAp46/48, and MBD3, but explicitly excludes Sin3 and Mi2. Which disease is associated with the gene involved in this specific interaction via a biomarker relationship? | thyroid tumor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03798","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MTA1 interacts with multiple genes. Evidence for one specific interaction indicates that the resulting complex contains HDAC1/2, RbAp46/48, and MBD3,... | |
medium_divergent_branch_03799 | SFPQ interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we demonstrate a direct interaction between topoisomerase I and pyrimidine tract binding protein-associated splicing factor (PSF), a cofactor of RNA splicing, which forms heterodimers with its smaller homolog, the nuclear RNA-b... | liver cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03799","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SFPQ interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we demonstrate a direct interaction between topoisomeras... | |
medium_divergent_branch_03800 | RSPO4 interacts with multiple receptor proteins. Experimental evidence from a time-resolved fluorescence resonance energy transfer (TR-FRET) assay indicates that RSPOs bind to the leucine-rich repeat domains (LRR1-14) of a specific receptor with nanomolar affinities, following the order: the selected receptor > RSPO2 >... | plasma membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03800","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RSPO4 interacts with multiple receptor proteins. Experimental evidence from a time-resolved fluorescence resonance energy transfer (TR-FRET) assay in... | |
medium_divergent_branch_03802 | GGA2 interacts with multiple proteins. One specific interaction was identified using the proximity-dependent biotin identification (BioID) method, which revealed two RAB family small GTPases as novel interactors of GGA2: RAB10 and another protein. Which protein is this other interactor, and what protein does the gene f... | Ras-related protein Rab-13 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03802","source_qa_id":"medium_divergent_branch_02997","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"GGA2 interacts with multiple proteins. One specific interaction was identified using the proximit... | |
medium_divergent_branch_03803 | The gene CNTROB interacts with multiple partners. One specific interaction is supported by evidence stating that ectopic spindle pole-associated transient multipolarity and multipolar segregation in cells deficient for the partner gene are suppressed by removing centrobin, which interacts with and is ubiquitinated by t... | ulcer disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03803","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CNTROB interacts with multiple partners. One specific interaction is supported by evidence stating that ectopic spindle pole-associated tran... | |
medium_divergent_branch_03804 | The gene ARL8B is reported to interact with multiple partners. One specific interaction is described by the following evidence: 'Here, we report that Arl8b binds to the Rab4 and Rab14 interaction partner, RUN and FYVE domain-containing protein (RUFY) 1, a known regulator of cargo sorting from recycling endosomes.' Base... | RUN and FYVE domain-containing protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03804","source_qa_id":"medium_divergent_branch_02394","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene ARL8B is reported to interact with multiple partners. One specific interaction is descri... | |
medium_divergent_branch_03805 | APOB interacts with multiple proteins. One specific interaction involves a site on APOB between residues 512 and 721 interacting with residues 517-603 of a protein encoded by the gene connected to APOB via this specific interaction. Which protein, encoded by this gene, is the target of the 'encodes' relation? | Microsomal triglyceride transfer protein large subunit | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03805","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"APOB interacts with multiple proteins. One specific interaction involves a site on APOB between residues 512 and 721 interacting with residues 517-60... | |
medium_divergent_branch_03807 | UBE2N interacts with multiple ubiquitin-conjugating enzyme variants. One interaction is supported by evidence stating: 'Our finding suggests a novel regulatory mechanism in which different Uevs direct Ubcs to diverse cellular processes through physical interaction and alternative polyubiquitination.' Which protein, enc... | Ubiquitin-conjugating enzyme E2 variant 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03807","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBE2N interacts with multiple ubiquitin-conjugating enzyme variants. One interaction is supported by evidence stating: 'Our finding suggests a novel ... | |
medium_divergent_branch_03808 | The gene SCRIB interacts with multiple proteins. One interaction is supported by evidence stating: 'We identified several known and putative interactions potentially relevant to cellular signaling pathways and confirmed interactions between full-length Scribble and the target proteins β-PIX, plakophilin-4, and guanylat... | Rho guanine nucleotide exchange factor 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03808","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene SCRIB interacts with multiple proteins. One interaction is supported by evidence stating: 'We identified several known and putative interact... | |
medium_divergent_branch_03809 | Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.496 and an adjusted p-value of 0.0493. Which protein does that selected gene encode? | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03809","source_qa_id":"medium_divergent_branch_01302","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showe... | |
medium_divergent_branch_03810 | ORC1 interacts with multiple genes. One of these interacting partners is described in the literature as physically interacting with ORC1 on non-chromatin nuclear structures. Which disease is associated with this specific interacting gene? | Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03810","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ORC1 interacts with multiple genes. One of these interacting partners is described in the literature as physically interacting with ORC1 on non-chrom... | |
medium_divergent_branch_03811 | Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -2.226 and an adjusted p-value of 0.0281. For which disease is that selected gene recorded as a biomarker? | pediatric osteosarcoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03811","source_qa_id":"medium_divergent_branch_01659","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch sho... | |
medium_divergent_branch_03812 | ZNRF4 interacts with multiple proteins. One interaction partner is described by the following evidence: 'A fraction of the protein encoded by the interacting gene localizes to the endoplasmic reticulum (ER), where it interacts with this partner under either unstimulated and muramyl dipeptide-stimulated conditions.' Whi... | Receptor-interacting serine/threonine-protein kinase 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03812","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZNRF4 interacts with multiple proteins. One interaction partner is described by the following evidence: 'A fraction of the protein encoded by the int... | |
medium_divergent_branch_03813 | The gene RCHY1 is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'We found that Pirh2 (p53-induced RING-H2) E3 ubiquitin ligase physically interacts with a target protein and targets this protein for polyubiquitination and subsequently proteasomal degradation.' Base... | Tumor protein 63 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03813","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene RCHY1 is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'We found that Pirh2 (p53-indu... | |
medium_divergent_branch_03814 | POLR1A interacts with multiple genes. One of these interacting partners is described as a widely expressed nucleolar protein associated with active rRNA genes (rDNA), where it interacts with RNA polymerase I (Pol I) as well as with histones. Which cell type is the gene matching this description enriched in? | eosinophil | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03814","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"POLR1A interacts with multiple genes. One of these interacting partners is described as a widely expressed nucleolar protein associated with active r... | |
medium_divergent_branch_03815 | TOMM40 is associated with multiple biological processes. One specific process is supported by evidence stating that Tom40 is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM complex), which is essential for protein import into mitochondria. Which cellular component is the target e... | mitochondrial matrix | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03815","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TOMM40 is associated with multiple biological processes. One specific process is supported by evidence stating that Tom40 is the channel-forming subu... | |
medium_divergent_branch_03816 | The biological process 'negative regulation of RNA export from nucleus' is defined as any process that stops, prevents, or reduces the frequency, rate, or extent of the directed movement of RNA from the nucleus into the cytoplasm. This process is a subtype of a broader regulatory process. Which biological process is ne... | nucleocytoplasmic transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03816","source_qa_id":"medium_divergent_branch_06919","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'negative regulation of RNA export from nucleus' is defined as any process... | |
medium_divergent_branch_03817 | The gene POLB is enriched in multiple cell types. One specific cell type shows a mean expression of 80.87 TPM, a z-score of 2.47, and a fold enrichment of 4.43. Which broader cell lineage is this specific cell type a subtype of? | dendritic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03817","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene POLB is enriched in multiple cell types. One specific cell type shows a mean expression of 80.87 TPM, a z-score of 2.47, and a fold enrichme... | |
medium_divergent_branch_03818 | RAD51 interacts with multiple proteins. One interaction is supported by evidence stating: 'In assays using purified components, phosphorylation of RAD51 by c-Abl enhances complex formation between RAD51 and this partner, which cooperates with RAD51 in recombination and repair.' What is the name of the protein encoded b... | DNA repair protein RAD52 homolog | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03818","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAD51 interacts with multiple proteins. One interaction is supported by evidence stating: 'In assays using purified components, phosphorylation of RA... | |
medium_divergent_branch_03819 | DLK1 is associated with multiple biological processes. One association is supported by evidence stating: 'In a number of in vitro culture systems, DLK1 stimulated osteoclastogenesis indirectly through osteoblast-dependent increased production of proinflammatory bone-resorbing cytokines (eg, Il7, Tnfa, and Ccl3).' Which... | osteoclast differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03819","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DLK1 is associated with multiple biological processes. One association is supported by evidence stating: 'In a number of in vitro culture systems, DL... | |
medium_divergent_branch_03820 | GAS2L3 is associated with multiple biological processes. One specific association is supported by evidence stating that GAS2-like 3 interacts with filamentous actin and microtubules (MTs) via its single calponin homology type 3 domain and C terminus, respectively. Which cellular component is the result of the organizat... | actin cytoskeleton | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03820","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GAS2L3 is associated with multiple biological processes. One specific association is supported by evidence stating that GAS2-like 3 interacts with fi... | |
medium_divergent_branch_03821 | CFL1 interacts with multiple proteins. One specific interaction involves cofilin-1 and PKCζ, which was evidenced and found to be enhanced in EGF-induced chemotaxis signaling transduction. Which protein is encoded by the gene corresponding to this interacting partner? | Protein kinase C zeta type | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03821","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CFL1 interacts with multiple proteins. One specific interaction involves cofilin-1 and PKCζ, which was evidenced and found to be enhanced in EGF-indu... | |
medium_divergent_branch_03822 | ELL2 interacts with multiple genes. One of these interacting partners is supported by evidence stating: 'In addition, endogenous [the partner] also exhibited the capacity to interact with ELL2.' Which biological process is this specific interacting partner involved in? | regulation of transcription elongation by RNA polymerase II | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03822","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ELL2 interacts with multiple genes. One of these interacting partners is supported by evidence stating: 'In addition, endogenous [the partner] also e... | |
medium_divergent_branch_03823 | ASXL1 interacts with multiple proteins. One of these interaction partners is described in the literature as follows: 'It has been reported that nonsense mutations in ASXL1 promote an interaction with [this protein], another central epigenetic regulator.' Which protein is this interaction partner? | Bromodomain-containing protein 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03823","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ASXL1 interacts with multiple proteins. One of these interaction partners is described in the literature as follows: 'It has been reported that nonse... | |
medium_divergent_branch_03824 | PBK interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show, by co-immunoprecipitation experiments and yeast two-hybrid analysis, that PBK/TOPK physically interacts with the tumor suppressor [protein encoded by TP53] through its DNA-binding (DBD) domain in HCT116 colorectal car... | Cellular tumor antigen p53 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03824","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PBK interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show, by co-immunoprecipitation experiments and yeas... | |
medium_divergent_branch_03825 | KMT2C interacts with multiple proteins. One of these interaction partners is part of a complex that exhibits robust histone methyltransferase activity, specifically methylating lysine 4 (K4) on histone H3. Which protein product is encoded by the gene corresponding to this specific interaction partner? | PAX-interacting protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03825","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KMT2C interacts with multiple proteins. One of these interaction partners is part of a complex that exhibits robust histone methyltransferase activit... | |
medium_divergent_branch_03826 | MRE11A interacts with multiple proteins. One of these interaction partners is explicitly identified in the literature as a binding partner of the MRE11-RAD50-NBS1 (MRN) complex. Which protein, connected to MRE11A via an interaction, is described by this specific evidence? | Transcriptional regulator ATRX | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03826","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MRE11A interacts with multiple proteins. One of these interaction partners is explicitly identified in the literature as a binding partner of the MRE... | |
medium_divergent_branch_03828 | ARL3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Finally, we find that the protein interacts with GTP-bound ADP ribosylation factor-like 3 protein, providing a link between the protein and several retinal-specific proteins, mutations in which also cause retinitis pigmentosa.' Wh... | Protein XRP2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03828","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARL3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Finally, we find that the protein interacts with GTP-bound ... | |
medium_divergent_branch_03829 | The gene PLD2 is enriched in multiple cell types. One specific cell type shows a mean expression of 4.45 TPM, a z-score of 1.75, and a fold enrichment of 2.51 for PLD2. Which cell type does this specific cell develop from? | intermediate monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03829","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PLD2 is enriched in multiple cell types. One specific cell type shows a mean expression of 4.45 TPM, a z-score of 1.75, and a fold enrichmen... | |
medium_divergent_branch_03830 | PRKCZ interacts with multiple genes. One specific interaction is supported by evidence showing that PKCzeta associates with the target gene, and this association is enhanced by TSA. Which disease is linked to this target gene through genomic alterations? | hypertensive disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03830","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRKCZ interacts with multiple genes. One specific interaction is supported by evidence showing that PKCzeta associates with the target gene, and this... | |
medium_divergent_branch_03831 | SMAD3 interacts with multiple proteins. One such interaction is supported by evidence stating: 'In both yeast two-hybrid and in vitro binding assays, we found that this protein could interact with receptor-activated Smads (R-Smads), including Smad1, Smad2, and Smad3 but not Smad4.' Which disease is associated with this... | lung adenocarcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03831","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMAD3 interacts with multiple proteins. One such interaction is supported by evidence stating: 'In both yeast two-hybrid and in vitro binding assays,... | |
medium_divergent_branch_03832 | BCL9 interacts with multiple genes. One of these interaction partners is involved in a complex where LATS2 inhibits its interaction with β-catenin and its subsequent recruitment, a process that occurs independently of LATS2 kinase activity. Which disease is causally linked to this specific interaction partner? | proteinuria | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03832","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BCL9 interacts with multiple genes. One of these interaction partners is involved in a complex where LATS2 inhibits its interaction with β-catenin an... | |
medium_divergent_branch_03833 | BRPF1 is associated with multiple biological processes. One association is supported by evidence describing BRPF1 as a multivalent chromatin regulator. Which biological process, connected to the process supported by this evidence via an 'is a' relationship, represents the broader category? | chromatin organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03833","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BRPF1 is associated with multiple biological processes. One association is supported by evidence describing BRPF1 as a multivalent chromatin regulato... | |
medium_divergent_branch_03835 | UBE2S interacts with multiple proteins. One interaction is supported by evidence stating: 'Immunoprecipitation, immunofluorescent staining, GST pull-down and in vitro binding assays revealed direct binding of UBE2S with IκBα.' Which protein, encoded by the gene connected to UBE2S via this specific interaction evidence,... | NF-kappa-B inhibitor alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03835","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBE2S interacts with multiple proteins. One interaction is supported by evidence stating: 'Immunoprecipitation, immunofluorescent staining, GST pull-... | |
medium_divergent_branch_03836 | The gene DPCD is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 18.53 TPM, a z-score of 1.84, and a fold enrichment of 4.41. Which cell type corresponds to this specific statistical profile, and what is its direct parent class in the cellular hierar... | monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03836","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene DPCD is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 18.53 TPM, a z... | |
medium_divergent_branch_03837 | ARFGEF2 interacts with multiple proteins. One of these interactions is supported by evidence stating: 'Direct interaction of BIG1 N-terminal sequence with β-catenin was confirmed using yeast two-hybrid assays and in vitro synthesized proteins.' Which protein product is encoded by the gene corresponding to this specific... | Catenin beta-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03837","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARFGEF2 interacts with multiple proteins. One of these interactions is supported by evidence stating: 'Direct interaction of BIG1 N-terminal sequence... | |
medium_divergent_branch_03838 | PDGFRA interacts with multiple genes. One specific interaction is supported by evidence stating: 'In vitro, the N-terminal fragment of this gene product directly bound to PDGFR alpha derived from PDGF-AA-stimulated cells but not to that from unstimulated cells, and this binding was abrogated by a point mutation (G306E)... | core binding factor acute myeloid leukemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03838","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PDGFRA interacts with multiple genes. One specific interaction is supported by evidence stating: 'In vitro, the N-terminal fragment of this gene prod... | |
medium_divergent_branch_03839 | The gene LAT interacts with multiple other genes. One of these interacting partners is supported by evidence stating: 'Moreover, phospho-LAT appeared as a good substrate of activated [protein encoded by the interacting gene] in vitro and these two proteins interacted upon platelet activation by FcgammaRIIa cross-linkin... | Tyrosine-protein phosphatase non-receptor type 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03839","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene LAT interacts with multiple other genes. One of these interacting partners is supported by evidence stating: 'Moreover, phospho-LAT appeared... | |
medium_divergent_branch_03840 | ZBTB7C interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Coimmunoprecipitation, GST fusion protein pull-down, and immunocytochemistry assays show that the zinc-finger domain of Kr-pok interacts directly with the bZIP DNA binding domain of SREBP-1.' Which protein is encoded by... | Sterol regulatory element-binding protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03840","source_qa_id":"medium_divergent_branch_04775","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ZBTB7C interacts with multiple proteins. One specific interaction is supported by evidence statin... | |
medium_divergent_branch_03841 | SMURF1 interacts with multiple proteins. One of these interaction partners is described in evidence stating that Ndfip1 enhances the self-ubiquitination of the HECT domain-containing E3 ubiquitin ligase SMURF1 and its interaction with this partner, eventually promoting the partner's degradation. Which protein is this i... | Mitochondrial antiviral-signaling protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03841","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMURF1 interacts with multiple proteins. One of these interaction partners is described in evidence stating that Ndfip1 enhances the self-ubiquitinat... | |
medium_divergent_branch_03842 | RAD51 interacts with multiple proteins. One specific interaction partner forms a highly stable heterodimer with RAD51C, a complex that interacts weakly with RAD51, as demonstrated by nickel-nitrilotriacetic acid pull-down experiments. Which protein is this interaction partner? | DNA repair protein RAD51 homolog 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03842","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAD51 interacts with multiple proteins. One specific interaction partner forms a highly stable heterodimer with RAD51C, a complex that interacts weak... | |
medium_divergent_branch_03843 | ARFGEF2 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Using yeast two hybrid, co-immunoprecipitation in mammalian cells and direct protein binding approaches, we report here that GBF1 and a lipase enzyme interact directly and in cells, through multiple contact sites on each... | hemangioma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03843","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARFGEF2 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Using yeast two hybrid, co-immunoprecipitation in... | |
medium_divergent_branch_03844 | DNM1 interacts with multiple genes. One of these interacting partners is characterized by being concentrated at synapses in the brain and binding dynamin selectively through four N-terminal Src homology-3 (SH3) domains. Which biological process is this specific interacting gene involved in? | regulation of cell shape | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03844","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DNM1 interacts with multiple genes. One of these interacting partners is characterized by being concentrated at synapses in the brain and binding dyn... | |
medium_divergent_branch_03845 | FOXO1 interacts with multiple genes. One of these interaction partners is known to interact with FOXO1 in a viral infection-dependent manner, leading to the K48-linked polyubiquitination and cytosolic degradation of that partner. Which disease is associated with this specific interaction partner via a biomarker relatio... | arteriosclerosis disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03845","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FOXO1 interacts with multiple genes. One of these interaction partners is known to interact with FOXO1 in a viral infection-dependent manner, leading... | |
medium_divergent_branch_03846 | The gene PPP1CA interacts with multiple partners. One specific interaction involves a partner that binds to protein phosphatase PP1 and attenuates the translational elongation of key transcriptional factors through the dephosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha). Which protein is encoded by the... | Protein phosphatase 1 regulatory subunit 15A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03846","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PPP1CA interacts with multiple partners. One specific interaction involves a partner that binds to protein phosphatase PP1 and attenuates th... | |
medium_divergent_branch_03848 | NKX2-1 is involved in multiple biological processes. One specific process is supported by evidence stating: 'Moreover, the association of symptoms in the patients with NKX2-1 mutations points to an important role of human NKX2-1 in the development and function of thyroid, basal ganglia, and lung, as already described f... | endocrine system development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03848","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NKX2-1 is involved in multiple biological processes. One specific process is supported by evidence stating: 'Moreover, the association of symptoms in... | |
medium_divergent_branch_03849 | RASGRP3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using coimmunoprecipitation, we found that PMA induced the physical association of RASGRP3 with PKCdelta and, using in situ methods, we showed colocalization of PKCdelta and RASGRP3 in the perinuclear region.' Which protein is ... | Protein kinase C delta type | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03849","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RASGRP3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using coimmunoprecipitation, we found that PMA induced t... | |
medium_divergent_branch_03850 | PRKACA interacts with multiple proteins. One interaction was identified using a yeast two-hybrid method based on Son of Sevenless (SOS) recruitment to screen a chondrocyte cDNA library, revealing that the catalytic subunit of cyclic AMP (cAMP)-dependent protein kinase A (PKA-Calpha) interacted specifically with the tar... | Transcription factor SOX-9 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03850","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRKACA interacts with multiple proteins. One interaction was identified using a yeast two-hybrid method based on Son of Sevenless (SOS) recruitment t... | |
medium_divergent_branch_03852 | MAP2K7 interacts with multiple proteins. One interaction is supported by evidence that MKK7 co-precipitates with a fragment of a large multimodular and pleiotropic protein recognized as a SUMO E3 ligase. Which protein is encoded by the gene corresponding to this interacting partner? | E3 SUMO-protein ligase RanBP2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03852","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP2K7 interacts with multiple proteins. One interaction is supported by evidence that MKK7 co-precipitates with a fragment of a large multimodular a... | |
medium_divergent_branch_03853 | SLBP interacts with multiple proteins. One specific interaction was confirmed via co-immunoprecipitation experiments involving full-length SLBP, the interacting partner, and Cul4A. Which cellular component is the interacting partner located in? | Cul4-RING E3 ubiquitin ligase complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03853","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SLBP interacts with multiple proteins. One specific interaction was confirmed via co-immunoprecipitation experiments involving full-length SLBP, the ... | |
medium_divergent_branch_03854 | NTN1 interacts with multiple proteins. One interaction is characterized by the finding that sNetrin binds exclusively to the fifth fibronectin type III repeat of the target protein and to each immunoglobulin repeat of UNC5. Which protein, connected to NTN1 via this binding interaction, is encoded by the gene in questio... | Netrin receptor DCC | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03854","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NTN1 interacts with multiple proteins. One interaction is characterized by the finding that sNetrin binds exclusively to the fifth fibronectin type I... | |
medium_divergent_branch_03855 | RNF13 interacts with multiple proteins. One of these interaction partners is described in the evidence as a SNAP-25-interacting protein that directly interacted with RNF13. Which protein is this interaction partner? | SNARE-associated protein Snapin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03855","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF13 interacts with multiple proteins. One of these interaction partners is described in the evidence as a SNAP-25-interacting protein that directly... |
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