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medium_divergent_branch_03522 | NSFL1C interacts with multiple proteins. One of these interaction partners is supported by evidence stating that a specific protease interacts with the p97 protein 'segregase'. Which protein product is encoded by the gene corresponding to this specific interaction partner? | DNA-dependent metalloprotease SPRTN | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03522","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NSFL1C interacts with multiple proteins. One of these interaction partners is supported by evidence stating that a specific protease interacts with t... | |
medium_divergent_branch_03523 | CDK10 is associated with multiple cellular components via 'located in' relationships. One association is supported by evidence stating: 'Finally, the predominant isoforms were shown to have different subcellular distribution, due to an alternatively spliced nuclear localisation signal.' Identify the cellular component ... | intracellular membrane-bounded organelle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03523","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDK10 is associated with multiple cellular components via 'located in' relationships. One association is supported by evidence stating: 'Finally, the... | |
medium_divergent_branch_03525 | Desmoplakin (DSP) interacts with multiple proteins. One specific interaction is supported by evidence showing that DP-NTP binds to plakoglobin but not beta-catenin in a yeast two-hybrid system. Which protein is encoded by the gene corresponding to this specific binding partner? | Junction plakoglobin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03525","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Desmoplakin (DSP) interacts with multiple proteins. One specific interaction is supported by evidence showing that DP-NTP binds to plakoglobin but no... | |
medium_divergent_branch_03526 | The gene LPAR2 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'A human cDNA encoding a G protein-coupled receptor, designated Edg4, was identified by searching the GenBankTM for homologs of the human Edg2 LPA receptor.' Based on... | transmembrane signaling receptor activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03526","source_qa_id":"medium_divergent_branch_00918","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene LPAR2 is associated with multiple molecular functions via the 'enables' relationship. On... | |
medium_divergent_branch_03527 | The gene HYAL1 is associated with multiple cellular components via the 'located in' relationship. One line of evidence states: 'The results of the study indicated that rhHyal-1 is endocytosed by the liver, mainly by sinusoidal cells, and follows the intracellular pathway described for many endocytosed proteins that are... | lytic vacuole | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03527","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene HYAL1 is associated with multiple cellular components via the 'located in' relationship. One line of evidence states: 'The results of the st... | |
medium_divergent_branch_03528 | FBXO7 interacts with multiple proteins. One of these interactions is supported by evidence stating: 'We identify the subunit [protein name] as a direct interactor of FBXO7.' Which protein, connected to FBXO7 via this interaction, is encoded by the gene in question? | Golgi to ER traffic protein 4 homolog | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03528","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBXO7 interacts with multiple proteins. One of these interactions is supported by evidence stating: 'We identify the subunit [protein name] as a dire... | |
medium_divergent_branch_03529 | LILRB1 is associated with multiple biological processes. One specific association is supported by evidence stating that continuous ligation of LILRB1 modulated cellular differentiation, conferred a unique phenotype upon the resultant cells, induced a profound resistance to CD95-mediated cell death, and inhibited the se... | interleukin-10 production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03529","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LILRB1 is associated with multiple biological processes. One specific association is supported by evidence stating that continuous ligation of LILRB1... | |
medium_divergent_branch_03530 | Azurophilic granules are components of multiple cell types. One such cell is a basophil precursor in the granulocytic series, serving as an intermediate stage between a basophilic myelocyte and a band form basophil. This cell is characterized by an indented nucleus (where the indentation is less than half the distance ... | reniform nucleus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03530","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Azurophilic granules are components of multiple cell types. One such cell is a basophil precursor in the granulocytic series, serving as an intermedi... | |
medium_divergent_branch_03531 | HSPBP1 interacts with multiple proteins. Evidence for one of these interactions indicates that the interacting partner can bind not only to Hsp70 but also to the protein encoded by PGLYRP1. Which protein is this interacting partner? | Peptidoglycan recognition protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03531","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HSPBP1 interacts with multiple proteins. Evidence for one of these interactions indicates that the interacting partner can bind not only to Hsp70 but... | |
medium_divergent_branch_03532 | PPIA interacts with multiple proteins. Evidence for one of these interactions reports that CypA was co-immunoprecipitated with the target protein in vivo from the breast epithelial cell line T47D and Chinese hamster ovary transfectants overexpressing the target protein. Which protein is connected to the gene PPIA throu... | Prolactin receptor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03532","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PPIA interacts with multiple proteins. Evidence for one of these interactions reports that CypA was co-immunoprecipitated with the target protein in ... | |
medium_divergent_branch_03533 | MAVS interacts with multiple proteins. One of these interaction partners is induced following viral infection, and its binding to MAVS results in the proteasomal degradation of MAVS. Which protein is encoded by the gene corresponding to this specific interaction partner? | Poly(rC)-binding protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03533","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAVS interacts with multiple proteins. One of these interaction partners is induced following viral infection, and its binding to MAVS results in the... | |
medium_divergent_branch_03534 | SIX5 interacts with multiple genes. One of these interacting partners is part of a complex where coexpression with Six2 or Six4 induces the nuclear translocation of Eya1, Eya2, and this partner, which are otherwise cytoplasmic. Which disease is associated with this specific interacting partner? | sarcoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03534","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SIX5 interacts with multiple genes. One of these interacting partners is part of a complex where coexpression with Six2 or Six4 induces the nuclear t... | |
medium_divergent_branch_03535 | MLLT10 interacts with multiple proteins. One interaction is supported by evidence stating: 'The leucine zipper interacted with a protein previously identified as the product of an amplified gene in a glioblastoma.' Which protein, connected to MLLT10 via this specific interaction evidence, is the subject of the 'encodes... | YEATS domain-containing protein 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03535","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MLLT10 interacts with multiple proteins. One interaction is supported by evidence stating: 'The leucine zipper interacted with a protein previously i... | |
medium_divergent_branch_03536 | FBXO45 interacts with multiple genes. One of these interaction partners is characterized by a mechanism where the key step is the recognition of EMT transcription factors by FBXO45 through its SPRY domain for this specific partner, or through its F-box domain for the other three EMT transcription factors (Snai1, Snai2,... | early T cell progenitor acute lymphoblastic leukemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03536","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBXO45 interacts with multiple genes. One of these interaction partners is characterized by a mechanism where the key step is the recognition of EMT ... | |
medium_divergent_branch_03537 | In a study of Human mastadenovirus C infection in lung fibroblast cell lines (GSE120891), one downregulated gene exhibits a log2 fold change of -2.332 and an adjusted p-value of 0.04588. Which protein is encoded by this specific gene? | Histamine H2 receptor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03537","source_qa_id":"medium_divergent_branch_03734","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"In a study of Human mastadenovirus C infection in lung fibroblast cell lines (GSE120891), one dow... | |
medium_divergent_branch_03538 | FANCC interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Binding was confirmed by coimmunoprecipitation of FAC and a heat shock protein from cytosolic, but not nuclear, lysates of transfected COS-1 cells, as well as from mouse liver cytoplasmic extracts.' Which protein product... | Endoplasmin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03538","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FANCC interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Binding was confirmed by coimmunoprecipitation of... | |
medium_divergent_branch_03540 | HOXB13 interacts with multiple proteins. One specific interaction is characterized by evidence stating that the complex alters chromatin accessibility at HOXB13-binding sites, leading to increased proliferation in androgen receptor (AR)-negative prostate cancer. Which protein, connected to HOXB13 via an interaction, is... | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03540","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HOXB13 interacts with multiple proteins. One specific interaction is characterized by evidence stating that the complex alters chromatin accessibilit... | |
medium_divergent_branch_03541 | The gene ADORA1 is associated with multiple biological processes. One specific association is supported by evidence showing that in cells co-expressing A1R and P2Y1R, there is an ADPbetaS-dependent reduction of forskolin-evoked cAMP accumulation, which is sensitive to pertussis toxin and an A1R antagonist. What is the ... | purinergic nucleotide receptor signaling pathway | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03541","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ADORA1 is associated with multiple biological processes. One specific association is supported by evidence showing that in cells co-expressi... | |
medium_divergent_branch_03542 | RARA interacts with multiple proteins. One interaction is described by the statement: 'We show here that the interacting partner interacts with and enhances transcriptional activation by RARα.' Which protein corresponds to this description, and what is the name of the protein product encoded by the gene for this intera... | Alpha-actinin-4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03542","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RARA interacts with multiple proteins. One interaction is described by the statement: 'We show here that the interacting partner interacts with and e... | |
medium_divergent_branch_03543 | MARCH8 interacts with multiple proteins. One interaction is supported by evidence stating that the MARCHF8 protein directly interacts with and ubiquitinates TNFRSF death receptors. Which protein, connected to MARCH8 via this specific interaction evidence, is encoded by the gene in question? | Tumor necrosis factor receptor superfamily member 10B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03543","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MARCH8 interacts with multiple proteins. One interaction is supported by evidence stating that the MARCHF8 protein directly interacts with and ubiqui... | |
medium_divergent_branch_03544 | CD40LG is associated with multiple biological processes. One association is supported by evidence stating: 'We also demonstrate that signaling through CD40L activates NF-kappaB and induces apoptosis in ECs.' Which biological process is positively regulated by the process linked to CD40LG via this specific evidence? | endothelial cell apoptotic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03544","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CD40LG is associated with multiple biological processes. One association is supported by evidence stating: 'We also demonstrate that signaling throug... | |
medium_divergent_branch_03545 | AURKA interacts with multiple genes. One of these interaction partners is described in experimental evidence as follows: 'The E2 ubiquitin-conjugating enzyme was a preferential binding partner of the 'weak' STK15 Phe31 variant form in yeast two-hybrid screens and in human cells.' Which protein is encoded by the gene co... | Ubiquitin-conjugating enzyme E2 N | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03545","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AURKA interacts with multiple genes. One of these interaction partners is described in experimental evidence as follows: 'The E2 ubiquitin-conjugatin... | |
medium_divergent_branch_03546 | MNT is known to interact with multiple genes. One specific interaction partner is described by the following evidence: 'Like Max, this protein has no intrinsic transcriptional activity, but its association with Mad1, Mad4, Mnt or a partner of MLX can repress E-box-dependent transcription.' Which gene is linked to this ... | MLXIPL | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03546","source_qa_id":"medium_divergent_branch_07462","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"MNT is known to interact with multiple genes. One specific interaction partner is described by th... | |
medium_divergent_branch_03547 | EXOC2 interacts with multiple proteins. One of these interaction partners is described as inducing the assembly of catalytically active ULK1 and Beclin1-VPS34 complexes on the exocyst through direct binding to Exo84, a process required for isolation membrane formation and maturation. Which protein product is encoded by... | Ras-related protein Ral-B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03547","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EXOC2 interacts with multiple proteins. One of these interaction partners is described as inducing the assembly of catalytically active ULK1 and Becl... | |
medium_divergent_branch_03548 | CCN3 is associated with multiple biological processes. One specific association is supported by evidence stating that CCN3 induces neovascularization when implanted in rat cornea, demonstrating that it is a novel angiogenic inducer. Which biological process, connected to this specific process via a 'part of' relationsh... | blood vessel morphogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03548","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CCN3 is associated with multiple biological processes. One specific association is supported by evidence stating that CCN3 induces neovascularization... | |
medium_divergent_branch_03549 | MMP2 interacts with multiple proteins. One interaction is supported by evidence stating: 'We present evidence for the first time of a specific, high affinity interaction between TIMP-4 and the C domain of human gelatinase A and show that TIMP-4 binds both progelatinase A and the C domain in a similar manner to that of ... | Metalloproteinase inhibitor 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03549","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MMP2 interacts with multiple proteins. One interaction is supported by evidence stating: 'We present evidence for the first time of a specific, high ... | |
medium_divergent_branch_03550 | PGAM5 interacts with multiple proteins. One of these interaction partners is characterized by a specific binding mechanism: the N-terminus of the PGAM5 protein contains a conserved NXESGE motif that binds to the substrate binding pocket in the Kelch domain of this partner protein. Which gene encodes this specific inter... | Kelch-like ECH-associated protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03550","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PGAM5 interacts with multiple proteins. One of these interaction partners is characterized by a specific binding mechanism: the N-terminus of the PGA... | |
medium_divergent_branch_03551 | The CSK protein interacts with multiple partners. One interaction is supported by evidence stating: 'Using a GST fusion protein carrying the cytoplasmic tail of beta-dystroglycan, we identified five SH2 domain containing proteins that interact with beta-dystroglycan in a phosphorylation-dependent manner, including c-Sr... | muscular dystrophy-dystroglycanopathy, type A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03551","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The CSK protein interacts with multiple partners. One interaction is supported by evidence stating: 'Using a GST fusion protein carrying the cytoplas... | |
medium_divergent_branch_03552 | The gene DKC1 interacts with multiple partners. One specific interaction involves a partner that binds dyskerin/NAP57, the catalytic subunit of human H/ACA RNPs, an interaction modulated by mutations causing X-linked dyskeratosis congenita. Which protein is encoded by this specific interacting partner? | Protein SHQ1 homolog | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03552","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene DKC1 interacts with multiple partners. One specific interaction involves a partner that binds dyskerin/NAP57, the catalytic subunit of human... | |
medium_divergent_branch_03553 | ITGB3 interacts with multiple proteins. One of these interaction partners directly interacts with ITGB3 and suppresses its downstream signaling. Which protein is encoded by the gene corresponding to this interaction partner? | Migration and invasion-inhibitory protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03553","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ITGB3 interacts with multiple proteins. One of these interaction partners directly interacts with ITGB3 and suppresses its downstream signaling. Whic... | |
medium_divergent_branch_03555 | WNT5B is implicated in multiple biological processes. One line of evidence notes that a subset of genes, including WNT5B, WNT2B, WNT10B, FZD6, and FZD7, exhibited altered expression in human dermal fibroblasts (hDFs) exposed to DBP for 3 days. This evidence supports a specific biological process involving WNT5B. Which ... | chondrocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03555","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WNT5B is implicated in multiple biological processes. One line of evidence notes that a subset of genes, including WNT5B, WNT2B, WNT10B, FZD6, and FZ... | |
medium_divergent_branch_03556 | VAPB interacts with multiple genes. One specific interaction is supported by evidence stating: 'Moreover, hVAP-A and hVAP-B associated with each other through their respective TMDs.' Which disease is connected to the gene involved in this specific interaction through genomic alterations? | borderline personality disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03556","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VAPB interacts with multiple genes. One specific interaction is supported by evidence stating: 'Moreover, hVAP-A and hVAP-B associated with each othe... | |
medium_divergent_branch_03557 | MAP3K5 interacts with multiple genes. One of these interacting partners is a phosphatase that dephosphorylates phospho-Thr-838 in the activation loop of ASK1 in vitro and in interphase cells. Which disease is associated with this specific interacting gene? | leukemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03557","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP3K5 interacts with multiple genes. One of these interacting partners is a phosphatase that dephosphorylates phospho-Thr-838 in the activation loop... | |
medium_divergent_branch_03558 | The protein HGS interacts with multiple partners. One specific interaction partner is described as a regulator of receptor signaling and trafficking that interacts directly with Hrs, a mediator of the endocytic sorting of ubiquitinated membrane proteins. Which disease is associated with this specific interaction partne... | hypertensive disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03558","source_qa_id":"medium_divergent_branch_07354","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The protein HGS interacts with multiple partners. One specific interaction partner is described a... | |
medium_divergent_branch_03559 | KIF21A is associated with multiple biological processes via the 'involved in' relationship. One piece of evidence states: 'Here, we identified kinesin-4 (KIF21A) as an inhibitor of microtubule growth at the cell cortex.' Which biological process, connected to the process supported by this evidence through the 'regulate... | microtubule polymerization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03559","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KIF21A is associated with multiple biological processes via the 'involved in' relationship. One piece of evidence states: 'Here, we identified kinesi... | |
medium_divergent_branch_03560 | MARK2 interacts with multiple genes. One of these interacting partners has an interaction with MARK2 that was confirmed in vitro and in vivo by coimmunoprecipitation. Which disease is associated with this specific interacting gene? | prostate cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03560","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MARK2 interacts with multiple genes. One of these interacting partners has an interaction with MARK2 that was confirmed in vitro and in vivo by coimm... | |
medium_divergent_branch_03561 | RUNX1 is associated with multiple biological processes. One association is supported by evidence stating: 'The transcription factor RUNX1 is essential to establish the haematopoietic gene expression programme.' Which biological process, connected to the process described by this evidence via an 'is a' relationship, is ... | cell development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03561","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RUNX1 is associated with multiple biological processes. One association is supported by evidence stating: 'The transcription factor RUNX1 is essentia... | |
medium_divergent_branch_03562 | GNAI3 interacts with multiple proteins. One of these interaction partners is described as interacting with GDP-bound Galpha proteins, stimulating the release of GDP, and forming a stable nucleotide-free transition state complex with the Galpha protein, which dissociates upon GTP binding. Which protein is encoded by the... | Chaperone Ric-8A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03562","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GNAI3 interacts with multiple proteins. One of these interaction partners is described as interacting with GDP-bound Galpha proteins, stimulating the... | |
medium_divergent_branch_03563 | MACROH2A1 is associated with multiple biological processes. One association is supported by evidence stating: 'In this study, we show that the macroH2A1 isoforms play an important role in the regulation of lipid accumulation in hepatocytes.' Which biological process, connected to the process supported by this evidence ... | lipid metabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03563","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MACROH2A1 is associated with multiple biological processes. One association is supported by evidence stating: 'In this study, we show that the macroH... | |
medium_divergent_branch_03564 | BUB1B interacts with multiple genes. One of these interactions is supported by evidence stating: 'We show that a protein binds Mad2 when it is bound to the mitotic checkpoint complex (MCC) components BubR1 and Cdc20.' Which disease is associated with the gene identified by this evidence via a biomarker relationship? | Charcot-Marie-Tooth disease axonal type 2L | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03564","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BUB1B interacts with multiple genes. One of these interactions is supported by evidence stating: 'We show that a protein binds Mad2 when it is bound ... | |
medium_divergent_branch_03565 | Niacin interacts with multiple drugs. One of these interactions is associated with a risk of acute incompatibility reactions, specifically flush reactions involving the interacting drug, niacin, and calcium channel blockers. Which disease is the drug involved in this specific interaction indicated for? | type 2 diabetes mellitus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03565","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Niacin interacts with multiple drugs. One of these interactions is associated with a risk of acute incompatibility reactions, specifically flush reac... | |
medium_divergent_branch_03566 | EPCAM is associated with multiple biological processes. One association is supported by evidence showing that EPCAM knockdown resulted in marginal negative effects on OCT4 and TRA-1-60 expression, while cell proliferation decreased by more than 40%. Which biological process, connected to the process supported by this e... | stem cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03566","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EPCAM is associated with multiple biological processes. One association is supported by evidence showing that EPCAM knockdown resulted in marginal ne... | |
medium_divergent_branch_03567 | MAP2K6 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that the p38 MAPK activator MKK6, but not its close relatives MKK3 or MKK4, exhibited an increased affinity for the double-stranded RNA-activated protein kinase following the exposure of cells to poly(rI:rC), a dsRNA an... | Interferon-induced, double-stranded RNA-activated protein kinase | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03567","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP2K6 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that the p38 MAPK activator MKK6, but not its cl... | |
medium_divergent_branch_03568 | In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Human respirovirus 3 was found to upregulate a specific gene with a log2 fold change of 2.373 and an adjusted p-value of 0.04216. Which protein is encoded by this upregulated gene? | Pro-MCH | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03568","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Human respirovirus 3 was found to upregulate a specific gene with a log2 fol... | |
medium_divergent_branch_03569 | ARRB2 interacts with multiple genes. One interaction is supported by evidence stating: 'Here we show that a ubiquitin ligase directly interacts with the amino-terminal half of nonvisual arrestin-2 via its WW domains.' Which disease is associated with the gene identified by this evidence? | syndromic multisystem autoimmune disease due to ITCH deficiency | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03569","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARRB2 interacts with multiple genes. One interaction is supported by evidence stating: 'Here we show that a ubiquitin ligase directly interacts with ... | |
medium_divergent_branch_03570 | PSMA7 interacts with multiple proteins. One interaction is supported by evidence stating: 'The binding of TP beta with alpha 7 and PA28 gamma was confirmed by co-immunoprecipitation and pull-down assays.' Which protein, connected to PSMA7 via this specific interaction evidence, is encoded by the gene in question? | Thromboxane A2 receptor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03570","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PSMA7 interacts with multiple proteins. One interaction is supported by evidence stating: 'The binding of TP beta with alpha 7 and PA28 gamma was con... | |
medium_divergent_branch_03571 | The gene DFFB is associated with multiple biological processes. One association is supported by evidence stating that the DNA fragmentation factor (DFF) complex, comprising DFF40 and DFF45, is activated during apoptosis to induce DNA fragmentation. Which biological process, connected to the process supported by this ev... | DNA catabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03571","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene DFFB is associated with multiple biological processes. One association is supported by evidence stating that the DNA fragmentation factor (D... | |
medium_divergent_branch_03572 | TRIM23 interacts with multiple genes. One of these interaction partners is supported by evidence stating: 'Here, we showed that two E3 ligases, TRIM23 and TRIM21, physically interact with the C terminus of this protein.' Which disease is connected to this specific interacting gene through genomic alterations? | gnathodiaphyseal dysplasia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03572","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM23 interacts with multiple genes. One of these interaction partners is supported by evidence stating: 'Here, we showed that two E3 ligases, TRIM2... | |
medium_divergent_branch_03573 | MTOR interacts with multiple proteins. One interaction involves a partner that is directly phosphorylated by mTORC1 at Serine 64, a modification that protects the partner from ubiquitination and degradation. Which protein, encoded by the gene connected to MTOR via this specific interaction, is being described? | S-phase kinase-associated protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03573","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MTOR interacts with multiple proteins. One interaction involves a partner that is directly phosphorylated by mTORC1 at Serine 64, a modification that... | |
medium_divergent_branch_03574 | TIAM1 interacts with multiple proteins. Evidence for one of these interactions specifically cites GST pull-down and CLIP assays. Which protein, among those interacting with TIAM1, is supported by this specific experimental evidence? | Histone-lysine N-methyltransferase SETDB1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03574","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TIAM1 interacts with multiple proteins. Evidence for one of these interactions specifically cites GST pull-down and CLIP assays. Which protein, among... | |
medium_divergent_branch_03575 | DNAJC19 interacts with multiple proteins. One interaction is supported by evidence stating that a specific protein forms a stable subcomplex with the J-protein Pam18 or the interacting partner through its C-terminal region, and this complex is tethered to the TIM23 complex in yeast and humans. Which protein, encoded by... | Mitochondrial import inner membrane translocase subunit TIM16 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03575","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DNAJC19 interacts with multiple proteins. One interaction is supported by evidence stating that a specific protein forms a stable subcomplex with the... | |
medium_divergent_branch_03577 | The protein ACTN1 is involved in multiple biological processes. One specific process is supported by evidence showing that transduction of mouse fetal liver-derived megakaryocytes with disease-associated ACTN1 variants caused a disorganized actin-based cytoskeleton, resulting in the production of abnormally large propl... | platelet morphogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03577","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein ACTN1 is involved in multiple biological processes. One specific process is supported by evidence showing that transduction of mouse feta... | |
medium_divergent_branch_03578 | CD160 is associated with multiple biological processes. One association is supported by evidence stating: 'We show here that the Ig-like CD160 receptor expressed by circulating CD56(dim+) NK cells or IL-2-deprived NK cell lines is mainly involved in their cytotoxic activity against K562 target cells.' Which biological ... | natural killer cell mediated cytotoxicity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03578","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CD160 is associated with multiple biological processes. One association is supported by evidence stating: 'We show here that the Ig-like CD160 recept... | |
medium_divergent_branch_03579 | KCNE1 is associated with multiple biological processes. One association is supported by evidence stating: 'The functional consequences of these mutations would be delayed cardiac repolarization and an increased risk of arrhythmia.' Which biological process is a parent term (via an 'is a' relationship) of the specific p... | regulation of cardiac muscle cell membrane repolarization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03579","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KCNE1 is associated with multiple biological processes. One association is supported by evidence stating: 'The functional consequences of these mutat... | |
medium_divergent_branch_03580 | C9orf72 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here, we found that C9orf72 forms a complex with this protein and SMCR8 to act as a GDP/GTP exchange factor for RAB8a and RAB39b and to thereby control autophagic flux.' Which gene does this interaction partner interact w... | RAB9A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03580","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"C9orf72 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here, we found that C9orf72 forms a complex with t... | |
medium_divergent_branch_03582 | LARP1 is associated with multiple biological processes. One association is supported by evidence stating: 'Our data show that mammalian Larp1 is found in a complex with poly A binding protein and eukaryote initiation factor 4E and is associated with 60S and 80S ribosomal subunits.' Which biological process, connected t... | metabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03582","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LARP1 is associated with multiple biological processes. One association is supported by evidence stating: 'Our data show that mammalian Larp1 is foun... | |
medium_divergent_branch_03583 | The gene CATSPERB is associated with multiple biological processes. One of these processes is supported by evidence stating that 'The cation channel of sperm (CatSper) is essential for sperm motility and fertility.' Identify the anatomical structure associated with this specific biological process. | hermaphrodite gonad | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03583","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CATSPERB is associated with multiple biological processes. One of these processes is supported by evidence stating that 'The cation channel ... | |
medium_divergent_branch_03584 | SMAD2 interacts with multiple genes. One specific interaction partner is characterized by evidence showing it binds to SMAD2 and SMAD3, but not SMAD4, with this binding being enhanced by the phosphorylation of (S/T)P motifs in the Smad linker region. Which disease is associated with this specific interaction partner vi... | malignant pancreatic neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03584","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMAD2 interacts with multiple genes. One specific interaction partner is characterized by evidence showing it binds to SMAD2 and SMAD3, but not SMAD4... | |
medium_divergent_branch_03585 | AURKA interacts with multiple genes. One of these interacting partners has been shown to interact with Aurora-A directly in both in vitro and in vivo settings. Which gene is this interacting partner? | DCAF1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03585","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AURKA interacts with multiple genes. One of these interacting partners has been shown to interact with Aurora-A directly in both in vitro and in vivo... | |
medium_divergent_branch_03586 | MAD1L1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that [Protein X] forms incompatible complexes with Mad1 and Cdc20, neither of which requires [Protein X] oligomerization.' Which protein, encoded by the gene connected to MAD1L1 via this specific interaction, is the... | Mitotic spindle assembly checkpoint protein MAD2A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03586","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAD1L1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that [Protein X] forms incompatible complexe... | |
medium_divergent_branch_03587 | CNTFR interacts with multiple proteins. One interaction is supported by evidence stating: 'We reported previously that the membrane distal cytokine-binding domain (CBD1) of this protein could interact in vitro with soluble CNTFR (sCNTFR) in the absence of CNTF.' What is the name of the protein encoded by the gene corre... | Leukemia inhibitory factor receptor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03587","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CNTFR interacts with multiple proteins. One interaction is supported by evidence stating: 'We reported previously that the membrane distal cytokine-b... | |
medium_divergent_branch_03588 | CASP9 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that X-linked IAP mediates the polyubiquitination of caspase-9 and Smac.' Which disease is associated with this interaction partner via a protective relationship? | retinitis pigmentosa | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03588","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CASP9 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that X-linked IAP mediates the polyubiquitina... | |
medium_divergent_branch_03589 | The KIT gene interacts with multiple proteins. One interaction is characterized by the following evidence: 'Using a series of glutathione S-transferase (GST) fusion proteins containing either tyrosine-phosphorylated segments of the c-Kit cytosolic region or the SH2 domains of a specific protein tyrosine phosphatase, we... | Tyrosine-protein phosphatase non-receptor type 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03589","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The KIT gene interacts with multiple proteins. One interaction is characterized by the following evidence: 'Using a series of glutathione S-transfera... | |
medium_divergent_branch_03591 | LCP2 interacts with multiple proteins. One interaction is supported by evidence stating: 'By screening a human leukemia cDNA library, we identified the regulatory subunit of phosphoinositide 3-kinase (PI3K) as one of the interacting molecules.' Which protein is encoded by the gene corresponding to this interacting part... | Phosphatidylinositol 3-kinase regulatory subunit alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03591","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LCP2 interacts with multiple proteins. One interaction is supported by evidence stating: 'By screening a human leukemia cDNA library, we identified t... | |
medium_divergent_branch_03592 | APH1A interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that Aph-1 and Pen-2, two recently identified membrane proteins genetically linked to gamma-secretase, associate directly with presenilin and nicastrin in the active protease complex.' Which protein, connected to APH... | Gamma-secretase subunit PEN-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03592","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"APH1A interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that Aph-1 and Pen-2, two recently identified... | |
medium_divergent_branch_03593 | The protein ACTG1 is localized to multiple cellular components. One of these localizations is supported by evidence describing an apical gamma-cytoplasmic actin pool composed of stable perijunctional bundles and rapidly turning-over nonjunctional filaments. What is the broader category (is_a relationship) of the specif... | anchoring junction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03593","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein ACTG1 is localized to multiple cellular components. One of these localizations is supported by evidence describing an apical gamma-cytopl... | |
medium_divergent_branch_03594 | TRIM65 interacts with multiple genes. One of these interaction partners is described as a critical tumor suppressor that TRIM65 binds to and targets for ubiquitination as an E3 ligase. Which disease is genetically associated with this specific interaction partner? | inflammatory disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03594","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM65 interacts with multiple genes. One of these interaction partners is described as a critical tumor suppressor that TRIM65 binds to and targets ... | |
medium_divergent_branch_03596 | WDR83 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we show that the WD40 protein Morg1 (mitogen-activated protein kinase organizer 1) directly binds to Par6 and thus facilitates apical targeting of Par6-aPKC in Madin-Darby canine kidney epithelial cells.' Which protein, enc... | Partitioning defective 6 homolog beta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03596","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WDR83 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we show that the WD40 protein Morg1 (mitogen-activat... | |
medium_divergent_branch_03597 | BCL6 interacts with multiple genes. One interaction is supported by evidence stating: 'The POZ domains of BCL-6 and several other POZ proteins interact with corepressors N-CoR and [a corepressor protein].' Which disease is associated with the gene identified by this specific interaction evidence, via a biomarker relati... | polyarticular arthritis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03597","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BCL6 interacts with multiple genes. One interaction is supported by evidence stating: 'The POZ domains of BCL-6 and several other POZ proteins intera... | |
medium_divergent_branch_03600 | PFKP interacts with multiple proteins. One of these interaction partners is an E3 ligase whose binding to PFKP is inhibited by AKT-mediated phosphorylation of PFKP at serine 386, thereby preventing the subsequent polyubiquitylation and degradation of PFKP. Which protein corresponds to this E3 ligase? | E3 ubiquitin-protein ligase TRIM21 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03600","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PFKP interacts with multiple proteins. One of these interaction partners is an E3 ligase whose binding to PFKP is inhibited by AKT-mediated phosphory... | |
medium_divergent_branch_03601 | TSG101 interacts with multiple genes. One of these interaction partners is characterized by evidence stating: 'Exogenous expression of mGFP-fused ALG-2 also restored the pulldown capability of Strep-Alix, but an alternatively spliced shorter ALG-2 isoform and a dimerization-defective mutant were incompetent.' Which cel... | plasmacytoid dendritic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03601","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TSG101 interacts with multiple genes. One of these interaction partners is characterized by evidence stating: 'Exogenous expression of mGFP-fused ALG... | |
medium_divergent_branch_03602 | DRAP1 interacts with multiple genes. Evidence for one of these interactions states: 'In the absence of the tethering domain, the interacting partner interacts with its corepressor DRAP1, but this interaction is not functional.' Which protein is encoded by the gene connected to DRAP1 through this specific interaction? | Protein Dr1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03602","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DRAP1 interacts with multiple genes. Evidence for one of these interactions states: 'In the absence of the tethering domain, the interacting partner ... | |
medium_divergent_branch_03603 | GABPA interacts with multiple transcription factors. One interaction is supported by evidence stating: 'Consistent with this result, we observed physical interaction of both Sp factors with the GABPalpha subunit in vitro.' Which protein is encoded by the gene that interacts with GABPA and is identified as one of these ... | Transcription factor Sp1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03603","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GABPA interacts with multiple transcription factors. One interaction is supported by evidence stating: 'Consistent with this result, we observed phys... | |
medium_divergent_branch_03604 | MAPK7 interacts with multiple genes. One interaction is supported by evidence stating: 'We found that both proteins interact directly with each other in vitro and in intact cells, resulting in mutual modulation of their enzymatic activities.' Which gene is connected to MAPK7 through this specific interaction? | TRIM11 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03604","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAPK7 interacts with multiple genes. One interaction is supported by evidence stating: 'We found that both proteins interact directly with each other... | |
medium_divergent_branch_03605 | The VHL gene interacts with multiple partners. One specific interaction involves a deubiquitinase that binds to and promotes the degradation of both wild-type and mutant forms of pVHL (provided they retain E3 ligase function), thereby activating the HIF pathway. Which protein is encoded by the gene corresponding to thi... | Ubiquitin carboxyl-terminal hydrolase 9X | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03605","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The VHL gene interacts with multiple partners. One specific interaction involves a deubiquitinase that binds to and promotes the degradation of both ... | |
medium_divergent_branch_03606 | DDX1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we identify the deubiquitinase [protein] as a central coordinator that interacts and co-localizes with RTCB and DDX1.' Which protein, encoded by the gene connected to DDX1 via this specific interaction, is described in this ... | Ubiquitin carboxyl-terminal hydrolase 45 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03606","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DDX1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we identify the deubiquitinase [protein] as a central... | |
medium_divergent_branch_03607 | The gene LAT interacts with multiple partners. One interaction is supported by evidence stating: 'We have recently investigated the role of the adaptor protein [candidate] in the early events of T cell signaling and observed that [candidate] associates with Grb2, linker for activation of T cells (LAT) and the TCR zeta-... | hepatocellular carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03607","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene LAT interacts with multiple partners. One interaction is supported by evidence stating: 'We have recently investigated the role of the adapt... | |
medium_divergent_branch_03608 | The rostral periventricular region of the third ventricle overlaps with multiple anatomical structures. One of these structures is described as a functional anatomical construct containing key estrogen-regulated inputs to gonadotropin-releasing hormone (GnRH) neurons, which are necessary for estrogen positive feedback.... | hypothalamic nucleus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03608","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The rostral periventricular region of the third ventricle overlaps with multiple anatomical structures. One of these structures is described as a fun... | |
medium_divergent_branch_03609 | RAB3A interacts with multiple proteins. One interaction partner is specifically recognized by a protein encoded by the gene connected to RAB3A via this specific interaction in its GTP-bound form, but not in its GDP-bound form. Which protein, encoded by the gene connected to RAB3A via this specific interaction, is the s... | Synaptotagmin-like protein 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03609","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAB3A interacts with multiple proteins. One interaction partner is specifically recognized by a protein encoded by the gene connected to RAB3A via th... | |
medium_divergent_branch_03610 | LIN7B interacts with multiple genes. One of these interaction partners is characterized by a PDZ-binding motif at its C-terminus that interacts with four different proteins containing PDZ domains: PSD-95, Lin-7b, MAGI-1b, and PIST. Which gene, connected to LIN7B through an interaction, is the subject of this specific e... | STOML3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03610","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LIN7B interacts with multiple genes. One of these interaction partners is characterized by a PDZ-binding motif at its C-terminus that interacts with ... | |
medium_divergent_branch_03611 | MAP3K2 interacts with multiple genes. One interaction is supported by evidence stating: 'By yeast two-hybrid library screening, we have identified a MAPK kinase in the big mitogen-activated protein kinase 1 (BMK1)/ERK5 pathway, as a binding partner for MEKK2.' Which cell type is enriched in the gene identified by this ... | natural killer cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03611","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP3K2 interacts with multiple genes. One interaction is supported by evidence stating: 'By yeast two-hybrid library screening, we have identified a ... | |
medium_divergent_branch_03612 | DLG4 interacts with multiple genes. One interaction is supported by evidence stating: 'Mutation of the C-terminal sequence (-ETDV) of the Shaker subunit [voltage-gated potassium channel subunit] abolishes its binding to, and prevents its clustering with, SAP97 and PSD-95.' Which disease is associated with the gene iden... | microcephaly, cataracts, impaired intellectual development, and dystonia with abnormal striatum | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03612","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DLG4 interacts with multiple genes. One interaction is supported by evidence stating: 'Mutation of the C-terminal sequence (-ETDV) of the Shaker subu... | |
medium_divergent_branch_03613 | COMMD1 interacts with multiple proteins. One interaction is characterized by the finding that the COMM domain of COMMD1 is required for its binding to this partner, and that other COMMD proteins can similarly interact with IAPs. Which cell type is enriched in the gene encoding this specific interaction partner? | basophil | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03613","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"COMMD1 interacts with multiple proteins. One interaction is characterized by the finding that the COMM domain of COMMD1 is required for its binding t... | |
medium_divergent_branch_03614 | The protein EPC1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'Strikingly, genetic ablation of either EPC1 or Tip60 disrupts hyperacetylation and impairs histone replacement, in turn causing aberrant [process].' Identify the biological process described in... | germ cell development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03614","source_qa_id":"medium_divergent_branch_03819","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The protein EPC1 is associated with multiple biological processes. One specific association is su... | |
medium_divergent_branch_03615 | Thyroglobulin (TG) is associated with multiple biological processes. One association is supported by evidence stating that Thyroglobulin is the protein precursor of thyroid hormones, which are essential for growth, development, and the control of metabolism in vertebrates. Which biological process, connected to the pro... | thyroid hormone metabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03615","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Thyroglobulin (TG) is associated with multiple biological processes. One association is supported by evidence stating that Thyroglobulin is the prote... | |
medium_divergent_branch_03616 | MIR15B is associated with multiple biological processes. One association is supported by evidence that miR-15b inhibits trophoblast cell invasion and endothelial cell tube formation by suppressing the expression of Argonaute 2 (AGO2). Which biological process, connected to MIR15B via an 'involved in' relationship, is t... | trophoblast cell migration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03616","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR15B is associated with multiple biological processes. One association is supported by evidence that miR-15b inhibits trophoblast cell invasion and... | |
medium_divergent_branch_03617 | TRIM33 interacts with multiple proteins. One interaction is supported by evidence stating: 'Through proteomic analysis we find that a chromatin remodeler interacts after DNA damage with Tripartite Motif-containing 33 (TRIM33), a multifunctional protein implicated in transcriptional regulation, TGF-β signaling, and tumo... | ATP-dependent chromatin remodeler CHD1L | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03617","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM33 interacts with multiple proteins. One interaction is supported by evidence stating: 'Through proteomic analysis we find that a chromatin remod... | |
medium_divergent_branch_03618 | DDX39A is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence stating that DDX39A facilitates RNA virus escape from innate immunity by trapping TRAF3, TRAF6, and MAVS mRNAs in the nucleus. Which biological process is negatively regulated by... | RNA export from nucleus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03618","source_qa_id":"medium_divergent_branch_03697","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"DDX39A is associated with multiple biological processes via the 'involved in' relationship. One s... | |
medium_divergent_branch_03619 | The protein OXA1L is associated with multiple cellular components via the 'located in' relationship. One of these associations is supported by evidence stating: 'Taken together, our results indicate that human Oxa1l represents a mitochondrial integral membrane protein required for the correct biogenesis of F(1)F(o)-ATP... | mitochondrial envelope | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03619","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein OXA1L is associated with multiple cellular components via the 'located in' relationship. One of these associations is supported by eviden... | |
medium_divergent_branch_03620 | GNB4 interacts with multiple proteins. One interaction is supported by evidence stating: 'The data show that PhLP1 plays a vital role in the assembly of Ggamma2 with all four Gbeta1-4 subunits and in the assembly of Gbeta2 with all twelve Ggamma subunits, without affecting the specificity of the Gbetagamma interactions... | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03620","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GNB4 interacts with multiple proteins. One interaction is supported by evidence stating: 'The data show that PhLP1 plays a vital role in the assembly... | |
medium_divergent_branch_03621 | TFG interacts with multiple proteins. One specific interaction is described as follows: 'Here, we identify TRK-Fused Gene (TFG), a protein involved in the transport of newly synthesized proteins to the endomembrane system via the Coat Protein complex II (COPII) transport vesicles, as a new [interacting partner]-interac... | plasma cell myeloma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03621","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TFG interacts with multiple proteins. One specific interaction is described as follows: 'Here, we identify TRK-Fused Gene (TFG), a protein involved i... | |
medium_divergent_branch_03622 | IRAK4 is known to bind to multiple proteins. One specific interaction involves endogenous IRAK-4 binding to IRAK-1 and a third protein in an IL-1-dependent manner. Identify the protein that corresponds to this third interaction partner, and then state the name of the protein product encoded by the gene for this partner... | TNF receptor-associated factor 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03622","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IRAK4 is known to bind to multiple proteins. One specific interaction involves endogenous IRAK-4 binding to IRAK-1 and a third protein in an IL-1-dep... | |
medium_divergent_branch_03623 | The embryonic cloacal fold is a component of multiple anatomical structures. One of these structures is described as follows: 'One of the pair of mesenchymal swellings (folds) located on either side of the cloacal membrane during the indifferent stage of embryonic development; cranial to the cloacal membrane the folds ... | multi-tissue structure | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03623","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The embryonic cloacal fold is a component of multiple anatomical structures. One of these structures is described as follows: 'One of the pair of mes... | |
medium_divergent_branch_03624 | Ixekizumab has a documented interaction with another drug. Clinical evidence regarding this interaction describes a patient who, after years of disease control with secukinumab and subsequently the interacting drug, developed a de novo eczematous eruption showing spongiotic dermatitis on biopsy. The patient was success... | rheumatoid arthritis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03624","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Ixekizumab has a documented interaction with another drug. Clinical evidence regarding this interaction describes a patient who, after years of disea... | |
medium_divergent_branch_03625 | SKP1 interacts with multiple proteins. One specific interaction partner is an F-box protein that, together with SKP1 and Cullin-1, forms the SCF complex to function as an E3 ubiquitin ligase. Which cellular component is this specific interaction partner located in? | SCF ubiquitin ligase complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03625","source_qa_id":"medium_divergent_branch_03710","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"SKP1 interacts with multiple proteins. One specific interaction partner is an F-box protein that,... | |
medium_divergent_branch_03626 | KLF2 interacts with multiple proteins. One interaction involves a HECT-type ubiquitin ligase that targets KLF2 for poly-ubiquitination and proteasomal degradation specifically in lung cancer H1299 cells. Which protein is encoded by the gene corresponding to this interacting partner? | E3 ubiquitin-protein ligase SMURF1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03626","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KLF2 interacts with multiple proteins. One interaction involves a HECT-type ubiquitin ligase that targets KLF2 for poly-ubiquitination and proteasoma... | |
medium_divergent_branch_03627 | The gene FANCG interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We have recently identified the structural protein nonerythroid alpha spectrin (alphaSpIISigma) as a component of a nuclear protein complex in normal human cells which is involved in the repair of DNA interstran... | Spectrin alpha chain, non-erythrocytic 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03627","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene FANCG interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We have recently identified the structur... | |
medium_divergent_branch_03628 | CLNS1A interacts with multiple genes. One interaction is supported by evidence stating that JBP1 binds SmD1 and SmD3 via their RG domains, while pICln binds the Sm domains. Which disease is associated with the gene described by this specific interaction evidence? | adenocarcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03628","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CLNS1A interacts with multiple genes. One interaction is supported by evidence stating that JBP1 binds SmD1 and SmD3 via their RG domains, while pICl... | |
medium_divergent_branch_03629 | ACSL4 interacts with multiple proteins. One interaction is characterized by the statement: 'Mechanistically, the interaction partner directly interacted with ACSL4 and promoted its ubiquitination and degradation.' Which protein, connected to ACSL4 via this specific interaction, is the subject of the 'encodes' relation? | F-box only protein 10 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03629","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ACSL4 interacts with multiple proteins. One interaction is characterized by the statement: 'Mechanistically, the interaction partner directly interac... | |
medium_divergent_branch_03630 | NFKB1 interacts with multiple genes. One interaction is supported by evidence stating: 'Evidence is presented for a direct interaction between the glucocorticoid receptor and the NF-kappa B subunits p65 and p50.' Which disease is therapeutically linked to the gene identified by this evidence? | asthma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03630","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NFKB1 interacts with multiple genes. One interaction is supported by evidence stating: 'Evidence is presented for a direct interaction between the gl... |
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