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medium_divergent_branch_03631 | FHL1 interacts with multiple genes. One of these interaction partners is a LIM domain-containing protein that increases inhibitory CDC25 phosphorylation by forming a complex with CHK2 and CDC25, and sequesters CDC25 in the cytoplasm by forming another complex with 14-3-3 and CDC25, resulting in increased radioresistanc... | conventional dendritic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03631","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FHL1 interacts with multiple genes. One of these interaction partners is a LIM domain-containing protein that increases inhibitory CDC25 phosphorylat... | |
medium_divergent_branch_03632 | The lymphotoxin-beta receptor (LTBR) interacts with multiple proteins. One specific interaction is characterized by the rapid recruitment of TNFR-associated factor 3 to the LTbeta R cytoplasmic domain upon treatment with LT alpha1 beta2 or agonistic LTbeta R antibodies. Which disease is associated with genomic alterati... | plasma cell myeloma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03632","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The lymphotoxin-beta receptor (LTBR) interacts with multiple proteins. One specific interaction is characterized by the rapid recruitment of TNFR-ass... | |
medium_divergent_branch_03633 | SLC4A11 is associated with multiple molecular functions. One specific function is supported by evidence stating: 'Here we identified SLC4A11, a member of the solute carrier family 4 of bicarbonate transporters, as an unexpected addition to known transmembrane water movement facilitators.' Which biological process is co... | water transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03633","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SLC4A11 is associated with multiple molecular functions. One specific function is supported by evidence stating: 'Here we identified SLC4A11, a membe... | |
medium_divergent_branch_03635 | PPP1R13B interacts with multiple proteins. One of these interaction partners is described in evidence stating: 'These effects are overridden by the Yap1 (Yes-associated protein 1) oncoprotein, which disrupts the [protein]-ASPP1 binding and antagonizes the tumor-suppressing function of the [protein]/ASPP1/p53 axis.' Whi... | Serine/threonine-protein kinase LATS2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03635","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PPP1R13B interacts with multiple proteins. One of these interaction partners is described in evidence stating: 'These effects are overridden by the Y... | |
medium_divergent_branch_03637 | MEIS2 interacts with multiple proteins. One interaction is supported by evidence stating: 'In pancreatic acinar cells, the HOX-like factor PDX1 acts as part of a trimeric complex with two TALE class homeodomain factors, PBX1b and MEIS2b.' Which protein, connected to MEIS2 via an interaction, is encoded by the gene corr... | Pre-B-cell leukemia transcription factor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03637","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MEIS2 interacts with multiple proteins. One interaction is supported by evidence stating: 'In pancreatic acinar cells, the HOX-like factor PDX1 acts ... | |
medium_divergent_branch_03638 | ANGPTL8 is associated with multiple biological processes. One association is supported by evidence stating: 'The findings that plasma triglyceride levels are reduced by Angptl8 deletion and increased following ANGPTL8 overexpression support the possibility that inhibition of ANGPTL8 represents a therapeutic strategy fo... | lipid metabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03638","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ANGPTL8 is associated with multiple biological processes. One association is supported by evidence stating: 'The findings that plasma triglyceride le... | |
medium_divergent_branch_03639 | The metanephric collecting duct is a subtype of two distinct anatomical categories. One of these categories is defined as a structure that is part of a metanephros. Which anatomical category is connected to the metanephric collecting duct through this 'is a' relationship? | excretory tube | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03639","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The metanephric collecting duct is a subtype of two distinct anatomical categories. One of these categories is defined as a structure that is part of... | |
medium_divergent_branch_03640 | MAP4K5 interacts with multiple proteins. One of these interaction partners was identified in an experiment where transient expression in HEK 293T cells, along with GCKR, resulted in co-immunoprecipitation with GCKR. Which protein is encoded by the gene corresponding to this interaction partner? | Crk-like protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03640","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP4K5 interacts with multiple proteins. One of these interaction partners was identified in an experiment where transient expression in HEK 293T cel... | |
medium_divergent_branch_03641 | TRIM22 interacts with multiple proteins. Evidence for one specific interaction indicates that domain mapping revealed the SPRY domain mediates interactions with the partner protein and FIP200, while the N-terminal region interacts with the partner protein and another entity. Which cellular component is this specific in... | phagophore assembly site | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03641","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM22 interacts with multiple proteins. Evidence for one specific interaction indicates that domain mapping revealed the SPRY domain mediates intera... | |
medium_divergent_branch_03642 | TRPC1 interacts with multiple genes. Evidence for one of these interactions indicates that the interacting partner forms channel complexes together with TRPC1 and TRPC5. Which disease is associated with this interacting gene as a biomarker? | head and neck cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03642","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRPC1 interacts with multiple genes. Evidence for one of these interactions indicates that the interacting partner forms channel complexes together w... | |
medium_divergent_branch_03643 | ABCA3 is associated with multiple cellular components via the 'located in' relationship. One association is supported by evidence stating: 'At the ultrastructural level, ABCA3 immunoreactivity was detected mostly at the limiting membrane of the lamellar bodies.' Which cell is connected to this specific cellular compone... | pulmonary alveolar type 2 cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03643","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ABCA3 is associated with multiple cellular components via the 'located in' relationship. One association is supported by evidence stating: 'At the ul... | |
medium_divergent_branch_03644 | The gene NCF1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We demonstrate that TNF-associated factor (TRAF) 4 associates with p47(phox), a component of cytosolic NADPH oxidase, and physically interacts and functionally counteracts with TRAF6 and Toll-IL-1 receptor (TIR) domain-co... | TNF receptor-associated factor 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03644","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene NCF1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We demonstrate that TNF-associated factor (TRAF) 4... | |
medium_divergent_branch_03645 | APOB interacts with multiple genes. One interaction is supported by evidence stating: 'Using coimmunoprecipitations, we observed associations of apoB with BiP, p97, a derlin family protein, VIMP, and the E3 ubiquitin ligase Hrd1 in HepG2 cells.' Which disease is connected to the gene identified in this specific interac... | acute myeloid leukemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03645","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"APOB interacts with multiple genes. One interaction is supported by evidence stating: 'Using coimmunoprecipitations, we observed associations of apoB... | |
medium_divergent_branch_03647 | MDK interacts with multiple proteins. Evidence for one of these interactions specifically identifies the partner as a novel MK-interacting protein. Which protein is this? | Phospholipid scramblase 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03647","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MDK interacts with multiple proteins. Evidence for one of these interactions specifically identifies the partner as a novel MK-interacting protein. W... | |
medium_divergent_branch_03648 | FBXO32 interacts with multiple proteins. One of these interaction partners is known to interact with all three endophilin-A proteins. Which protein, encoded by the gene connected to FBXO32 via this specific interaction, is the subject of this description? | Endophilin-A1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03648","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBXO32 interacts with multiple proteins. One of these interaction partners is known to interact with all three endophilin-A proteins. Which protein, ... | |
medium_divergent_branch_03649 | UHRF1 interacts with multiple genes. Evidence for one of these interactions states: 'We identified UHRF1 and USP7 as two new interaction partners for [the target gene].' Which disease is associated with this target gene via a biomarker relationship? | autism spectrum disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03649","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UHRF1 interacts with multiple genes. Evidence for one of these interactions states: 'We identified UHRF1 and USP7 as two new interaction partners for... | |
medium_divergent_branch_03650 | The gene BCL2L11 interacts with multiple partners. One interaction is supported by evidence stating: 'We found that, in response to survival signals, BimEL was rapidly phosphorylated on three serine residues in a conserved degron, facilitating binding and degradation via the F box protein betaTrCP.' Which disease is as... | neurodevelopmental, jaw, eye, and digital syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03650","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene BCL2L11 interacts with multiple partners. One interaction is supported by evidence stating: 'We found that, in response to survival signals,... | |
medium_divergent_branch_03652 | SIK1 interacts with multiple proteins. One specific interaction is characterized by the following evidence: 'Further, we showed that SIK1 phosphorylates this interaction partner at five conserved residues at its N-terminus, which is essential for the activation of MCM helicase.' What is the name of the protein encoded ... | DNA replication licensing factor MCM2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03652","source_qa_id":"medium_divergent_branch_01012","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"SIK1 interacts with multiple proteins. One specific interaction is characterized by the following... | |
medium_divergent_branch_03653 | ZBTB33 interacts with multiple proteins. One specific interaction partner is characterized by the statement: 'The RBCC domain of this protein interacts with the BTB/POZ domain and the zinc fingers of Kaiso.' Which disease is associated with this specific interacting partner via genomic alterations? | kidney Wilms tumor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03653","source_qa_id":"medium_divergent_branch_04224","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ZBTB33 interacts with multiple proteins. One specific interaction partner is characterized by the... | |
medium_divergent_branch_03655 | IGHMBP2 is associated with multiple molecular functions. One association is supported by evidence stating: 'Our data reveal that IGHMBP2 is an ATP-dependent 5' --> 3' helicase, which unwinds RNA and DNA duplices in vitro.' Which molecular function, connected to the function described by this evidence via an 'is_a' rela... | ATP-dependent activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03655","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IGHMBP2 is associated with multiple molecular functions. One association is supported by evidence stating: 'Our data reveal that IGHMBP2 is an ATP-de... | |
medium_divergent_branch_03656 | mmu-miR-142a regulates more than one cell type. Evidence for one of these regulatory connections reports that genetic ablation of miR-142 caused impaired maturation of the cell type, inhibition of polyploidization, abnormal proplatelet formation, and thrombocytopenia. Which anatomical structure is this cell type part o... | blood clot | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03656","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"mmu-miR-142a regulates more than one cell type. Evidence for one of these regulatory connections reports that genetic ablation of miR-142 caused impa... | |
medium_divergent_branch_03657 | EPAS1 interacts with multiple genes. One of these interaction partners is described in evidence stating: 'The new HIF2α partners microphthalmia-associated transcription factor, the shared gene, and AP2α, which are master actors of melanoma development, were confirmed via co-immunoprecipitation experiments.' Which prote... | Transcription factor SOX-10 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03657","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EPAS1 interacts with multiple genes. One of these interaction partners is described in evidence stating: 'The new HIF2α partners microphthalmia-assoc... | |
medium_divergent_branch_03658 | The gene CA6 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 5.88 TPM, a z-score of 1.85, and a fold enrichment of 3.97. Identify the cell type associated with these statistics, and then determine the precursor cell from which this cell type develops. | mature CD4 single-positive thymocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03658","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CA6 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 5.88 TPM, a z-score of 1.8... | |
medium_divergent_branch_03660 | EHMT2 interacts with multiple genes. One interaction is supported by evidence stating: 'Proteomic analysis of immunoprecipitates of a specific gene product and subsequent validation approaches revealed that this product associated with the epigenetic machinery especially UHRF1, DNMT1, G9a and the transcription factor S... | retinoblastoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03660","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EHMT2 interacts with multiple genes. One interaction is supported by evidence stating: 'Proteomic analysis of immunoprecipitates of a specific gene p... | |
medium_divergent_branch_03661 | CACYBP interacts with multiple proteins. One of these interaction partners is described as a member of the S100 subfamily of EF-hand Ca(2+) binding proteins that interacts with calcyclin binding protein/Siah-1 interacting protein (CacyBP/SIP), a subunit of an SCF-like E3 ubiquitin ligase complex (SCF-TBL1) formed under... | Protein S100-A6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03661","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CACYBP interacts with multiple proteins. One of these interaction partners is described as a member of the S100 subfamily of EF-hand Ca(2+) binding p... | |
medium_divergent_branch_03662 | The cardiac muscle tissue of the trabeculae carneae of the left ventricle is a subtype of two distinct anatomical entities. One of these entities is defined as a portion of the trabeculae carneae cardiac muscle tissue that is part of a left ventricle. Which of these two entities is connected to the starting tissue via ... | trabecula carnea | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03662","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The cardiac muscle tissue of the trabeculae carneae of the left ventricle is a subtype of two distinct anatomical entities. One of these entities is ... | |
medium_divergent_branch_03663 | SIRT3 interacts with multiple proteins. One of these interaction partners is specifically reported to be directly bound by SIRT3 and deacetylated at lysine 228 (K228). Which protein corresponds to this specific interaction partner? | Pyrroline-5-carboxylate reductase 1, mitochondrial | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03663","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SIRT3 interacts with multiple proteins. One of these interaction partners is specifically reported to be directly bound by SIRT3 and deacetylated at ... | |
medium_divergent_branch_03664 | DCAF8L2 interacts with multiple proteins. One of these interactions is characterized by the mechanism where DCAF8L2 targets the interacting partner for ubiquitination and degradation. Which protein is encoded by the gene corresponding to this specific interacting partner? | BRCA1-associated RING domain protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03664","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DCAF8L2 interacts with multiple proteins. One of these interactions is characterized by the mechanism where DCAF8L2 targets the interacting partner f... | |
medium_divergent_branch_03665 | The gene APOA2 is associated with multiple biological processes. One specific association is supported by evidence stating: 'In primary rat hepatocytes and in HepG2 cells, the transcription of the human apoA-II gene was upregulated by glucose.' Identify the biological process described by this evidence, and then determ... | response to hexose | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03665","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene APOA2 is associated with multiple biological processes. One specific association is supported by evidence stating: 'In primary rat hepatocyt... | |
medium_divergent_branch_03666 | CFL1 interacts with multiple genes. One of these interacting partners is supported by mass spectrometry and coimmunoprecipitation data demonstrating direct binding to cofilin-1. Which disease is associated with this specific interacting gene? | intellectual disability, autosomal recessive 45 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03666","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CFL1 interacts with multiple genes. One of these interacting partners is supported by mass spectrometry and coimmunoprecipitation data demonstrating ... | |
medium_divergent_branch_03667 | The gene MACF1 is known to interact with several other genes. One specific interaction is supported by evidence stating: 'Using a proteomic approach, we identified [the protein encoded by the interacting gene] as an Acf7-associated deubiquitinase.' Which protein is encoded by the gene identified in this evidence? | Ubiquitin carboxyl-terminal hydrolase 14 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03667","source_qa_id":"medium_divergent_branch_04181","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene MACF1 is known to interact with several other genes. One specific interaction is support... | |
medium_divergent_branch_03668 | The gene KCNK1 is associated with multiple cellular components via the 'located in' relationship. One of these associations is supported by evidence stating: 'Unlike other K(+) channel structures, K2P1 is dimeric.' Identify the molecular function that is connected to this specific cellular component through the 'capabl... | potassium channel activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03668","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene KCNK1 is associated with multiple cellular components via the 'located in' relationship. One of these associations is supported by evidence ... | |
medium_divergent_branch_03669 | DDB2 interacts with multiple proteins. One interaction is supported by evidence stating that the interacting partner and UV-DDB were demonstrated to interact physically, and both are polyubiquitylated by the recombinant UV-DDB-ubiquitin ligase complex. Which protein is encoded by the gene corresponding to this interact... | DNA repair protein complementing XP-C cells | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03669","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DDB2 interacts with multiple proteins. One interaction is supported by evidence stating that the interacting partner and UV-DDB were demonstrated to ... | |
medium_divergent_branch_03670 | Cortical interneurons are a subclass of two distinct neuronal categories. One of these categories is defined by the anatomical location of the cell body, specifically that the soma is located in the cerebral cortex. Which of these two parent categories is defined by this anatomical constraint? | neuron of the forebrain | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03670","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Cortical interneurons are a subclass of two distinct neuronal categories. One of these categories is defined by the anatomical location of the cell b... | |
medium_divergent_branch_03671 | WSB1 interacts with multiple genes. Evidence from RIP and RNA-pull down assays has clarified the binding between WSB1 and one of these interacting partners. Which protein is encoded by the gene that interacts with WSB1 and is supported by this specific experimental evidence? | Heterogeneous nuclear ribonucleoprotein L | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03671","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WSB1 interacts with multiple genes. Evidence from RIP and RNA-pull down assays has clarified the binding between WSB1 and one of these interacting pa... | |
medium_divergent_branch_03672 | The gene SLC38A1 is associated with multiple molecular functions. One association is supported by evidence stating: 'The transporter is specific for small short-chain neutral amino acids.' Identify the molecular function described by this evidence, and then determine the parent molecular function that is connected to i... | amino acid transmembrane transporter activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03672","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene SLC38A1 is associated with multiple molecular functions. One association is supported by evidence stating: 'The transporter is specific for ... | |
medium_divergent_branch_03673 | The gene GBA is associated with multiple biological processes. One association is supported by evidence that GBA encodes the lysosomal hydrolase glucocerebrosidase (GCase). Which biological process, connected to the process linked by this evidence via an 'is a' relationship, represents the broader category? | protein catabolic process in the vacuole | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03673","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene GBA is associated with multiple biological processes. One association is supported by evidence that GBA encodes the lysosomal hydrolase gluc... | |
medium_divergent_branch_03674 | ERBB2 interacts with multiple proteins. One interaction is supported by evidence stating: 'By immunoprecipitation and computational protein modeling techniques we have shown that the lapatinib-induced HER2 accumulation at the cell surface also results in the stabilization of inactive HER2 homo- (HER2/HER2) and hetero- ... | Parkinson disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03674","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ERBB2 interacts with multiple proteins. One interaction is supported by evidence stating: 'By immunoprecipitation and computational protein modeling ... | |
medium_divergent_branch_03675 | CASP8 interacts with multiple genes. One of these interacting partners is described in evidence stating that it and a related entity bind to two tandem DED-containing caspases, caspase-8 and -10, which are engaged by death receptors. Which protein is encoded by this interacting gene? | Death effector domain-containing protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03675","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CASP8 interacts with multiple genes. One of these interacting partners is described in evidence stating that it and a related entity bind to two tand... | |
medium_divergent_branch_03676 | RPH3A interacts with multiple proteins. One of these interaction partners is associated with a specific neurogenetic syndrome, and evidence indicates that a syndrome-linked missense mutation in this partner's region, which normally interacts with RPH3A, abrogates the interaction. Which protein is encoded by the gene co... | Ubiquitin-protein ligase E3A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03676","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RPH3A interacts with multiple proteins. One of these interaction partners is associated with a specific neurogenetic syndrome, and evidence indicates... | |
medium_divergent_branch_03677 | GGA3 interacts with multiple genes. One of these interaction partners is known to interact with L-type prostaglandin D synthase and regulates the recycling and signaling of the DP1 receptor for prostaglandin D. Which gene is this interaction partner? | PLAAT4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03677","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GGA3 interacts with multiple genes. One of these interaction partners is known to interact with L-type prostaglandin D synthase and regulates the rec... | |
medium_divergent_branch_03678 | The gene TBX6 is associated with multiple biological processes. One specific association is supported by evidence stating that the human TBX6 gene maps to chromosomal region 16p12-q12 and is likely to participate in paraxial mesoderm formation and somitogenesis in the human embryo. Which biological process, connected t... | developmental process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03678","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TBX6 is associated with multiple biological processes. One specific association is supported by evidence stating that the human TBX6 gene ma... | |
medium_divergent_branch_03679 | FOXE3 is associated with multiple biological processes. One of these processes is supported by evidence describing FOXE3 as a lens-specific transcription factor linked to anterior segment ocular dysgenesis. Which broader biological process is a parent of this specific process in the ontology hierarchy? | sensory organ development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03679","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FOXE3 is associated with multiple biological processes. One of these processes is supported by evidence describing FOXE3 as a lens-specific transcrip... | |
medium_divergent_branch_03680 | IRF1 interacts with multiple genes. One of these interacting partners is identified by evidence stating: 'By testing recombinant proteins, we show that a histone acetyltransferase directly binds to some but not all members of the IRF family through distinct domains of the two proteins.' Which disease is associated with... | glioblastoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03680","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IRF1 interacts with multiple genes. One of these interacting partners is identified by evidence stating: 'By testing recombinant proteins, we show th... | |
medium_divergent_branch_03681 | DCTN6 interacts with multiple proteins. One of these interaction partners is supported by evidence stating: 'In addition, the protein encoded by PMEPA1 interacts with the dynactin pointed-end complex subunits dynactin 5 and dynactin 6.' Which protein is encoded by the gene corresponding to this interaction partner? | Protein TMEPAI | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03681","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DCTN6 interacts with multiple proteins. One of these interaction partners is supported by evidence stating: 'In addition, the protein encoded by PMEP... | |
medium_divergent_branch_03682 | The thoracic vertebra cartilage element is a subclass of two distinct anatomical structures. One of these structures is defined as being composed primarily of cartilage tissue. Which anatomical structure is the thoracic vertebra cartilage element a part of, given that it is a subclass of the structure defined by its ca... | thoracic region of vertebral column | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03682","source_qa_id":"medium_divergent_branch_04952","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The thoracic vertebra cartilage element is a subclass of two distinct anatomical structures. One ... | |
medium_divergent_branch_03683 | ROR1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Treatment of CLL cells with Wnt5a induced ROR1 to oligomerize with this partner and recruit guanine exchange factors (GEFs), which activated Rac1 and RhoA.' What is the full protein name encoded by the gene corresponding to this i... | Tyrosine-protein kinase transmembrane receptor ROR2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03683","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ROR1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Treatment of CLL cells with Wnt5a induced ROR1 to oligomeri... | |
medium_divergent_branch_03684 | In a study of Orthohepevirus A infection in hepatocytes (GSE135619), one downregulated gene exhibits a log2 fold change of approximately -2.017 and an adjusted p-value of 0.04032. Which protein is encoded by this specific gene? | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03684","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"In a study of Orthohepevirus A infection in hepatocytes (GSE135619), one downregulated gene exhibits a log2 fold change of approximately -2.017 and a... | |
medium_divergent_branch_03685 | SMAD2 interacts with multiple proteins. One of these interaction partners was shown to bind SMAD2-4 and Miz-1 in a TGF-beta-independent manner, while its interaction with Myc required TGF-beta activation; these interactions collectively enhanced TGF-beta-induced p15 transcription. Which protein, encoded by the gene con... | Krueppel-like factor 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03685","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMAD2 interacts with multiple proteins. One of these interaction partners was shown to bind SMAD2-4 and Miz-1 in a TGF-beta-independent manner, while... | |
medium_divergent_branch_03686 | VAMP1 is associated with multiple cellular components. One association is supported by evidence stating that VAMP-1 was found in the membranes of gelatinase and specific secretory granules. Which cellular component, connected to the component described by this evidence via an 'is a' relationship, represents the broader... | secretory granule membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03686","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VAMP1 is associated with multiple cellular components. One association is supported by evidence stating that VAMP-1 was found in the membranes of gel... | |
medium_divergent_branch_03687 | UHRF2 is reported to interact with multiple genes. One specific interaction is characterized by physical binding in a DNA damage-dependent manner, mediated by the TTD domain of UHRF2. Which disease is associated with the gene involved in this specific interaction via a biomarker relationship? | fibrosarcoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03687","source_qa_id":"medium_divergent_branch_01567","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"UHRF2 is reported to interact with multiple genes. One specific interaction is characterized by p... | |
medium_divergent_branch_03689 | The gene TMPO interacts with multiple partners. One specific interaction is supported by evidence stating: 'Here I identified a LAP2 interacting protein, termed L2BP1 (LAP2 binding protein 1).' Which protein is encoded by the gene that interacts with TMPO in this specific context? | Barrier-to-autointegration factor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03689","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TMPO interacts with multiple partners. One specific interaction is supported by evidence stating: 'Here I identified a LAP2 interacting prot... | |
medium_divergent_branch_03690 | PHF8 interacts with multiple proteins. One interaction is supported by evidence stating: 'Our biochemical analysis revealed specific association of the PHF8 PHD with histone H3 trimethylated at lysine 4 (H3K4me3).' Which disease is linked to the protein identified in this specific interaction via genomic alterations? | squamous cell lung carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03690","source_qa_id":"medium_divergent_branch_04235","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"PHF8 interacts with multiple proteins. One interaction is supported by evidence stating: 'Our bio... | |
medium_divergent_branch_03692 | Neurofibromin (encoded by NF1) interacts with a specific protein partner. Evidence indicates that the EVH1 domain of this partner binds to the noncatalytic (GAPex) portion of the GAP-related domain (GRD) of neurofibromin. What is the name of the protein product encoded by the gene for this interacting partner? | Sprouty-related, EVH1 domain-containing protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03692","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Neurofibromin (encoded by NF1) interacts with a specific protein partner. Evidence indicates that the EVH1 domain of this partner binds to the noncat... | |
medium_divergent_branch_03693 | SKA1 interacts with multiple proteins. One specific interaction is supported by evidence stating that the two entities interact with each other and that SKA1 is required for the stability of the interacting partner in vivo. Which protein, encoded by the gene connected to SKA1 via this specific interaction, is the subje... | Spindle and kinetochore-associated protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03693","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SKA1 interacts with multiple proteins. One specific interaction is supported by evidence stating that the two entities interact with each other and t... | |
medium_divergent_branch_03694 | Primate erythroparvovirus 1 upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.023 and an adjusted p-value of 0.0429. Which disease has a genomic-alteration link with that selected gene? | myelodysplastic syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03694","source_qa_id":"medium_divergent_branch_06550","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Primate erythroparvovirus 1 upregulates several genes. In the recorded experiment, one branch ... | |
medium_divergent_branch_03695 | Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.842 and an adjusted p-value of 0.0452. Which protein does that selected gene encode? | Prickle-like protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03695","source_qa_id":"medium_divergent_branch_01386","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showe... | |
medium_divergent_branch_03696 | The glucocorticoid receptor (encoded by NR3C1) physically interacts with multiple proteins. One specific interaction partner is identified by evidence stating: 'Co-immunoprecipitation experiments in Hep3B cells indicated that physical interaction between GR and this protein is necessary but not sufficient for repressio... | aneurysm-osteoarthritis syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03696","source_qa_id":"medium_divergent_branch_01593","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The glucocorticoid receptor (encoded by NR3C1) physically interacts with multiple proteins. One s... | |
medium_divergent_branch_03697 | The gene ITGA8 is associated with multiple biological processes. One association is supported by evidence stating: 'These results demonstrate that mutations of ITGA8 are a genetic cause of bilateral renal agenesis and that, at least in some cases, bilateral renal agenesis is an autosomal-recessive disease.' Which biolo... | renal system development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03697","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ITGA8 is associated with multiple biological processes. One association is supported by evidence stating: 'These results demonstrate that mu... | |
medium_divergent_branch_03698 | MYCN interacts with multiple proteins. One of these interaction partners is described by the following evidence: 'Importantly, the protein directly bound to Myc oncoproteins and targeted Myc oncoproteins for ubiquitination and degradation.' Which protein is encoded by the gene corresponding to this interaction partner? | E3 ubiquitin-protein ligase NEDD4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03698","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MYCN interacts with multiple proteins. One of these interaction partners is described by the following evidence: 'Importantly, the protein directly b... | |
medium_divergent_branch_03699 | FLT1 interacts with multiple proteins. One interaction is supported by the statement: 'In this study we demonstrate that VEGF-B binds selectively to VEGF receptor-1/Flt-1.' Which protein is encoded by the gene corresponding to this interacting partner? | Vascular endothelial growth factor B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03699","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FLT1 interacts with multiple proteins. One interaction is supported by the statement: 'In this study we demonstrate that VEGF-B binds selectively to ... | |
medium_divergent_branch_03700 | The androgen receptor (AR) interacts with multiple proteins. One specific interaction partner is characterized by intrinsic transcriptional repression activity and direct binding to the silencing mediator for retinoid and thyroid hormone receptors. Which disease is associated with this specific interaction partner as a... | polyarticular arthritis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03700","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The androgen receptor (AR) interacts with multiple proteins. One specific interaction partner is characterized by intrinsic transcriptional repressio... | |
medium_divergent_branch_03701 | FANCD2 interacts with multiple genes. Evidence for one of these interactions indicates that FANCD2, the interacting partner, and RAD18 form a complex, a process that is enhanced upon hydroxyurea (HU) exposure. Which disease is associated with this interacting partner via a biomarker relationship? | uveal melanoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03701","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FANCD2 interacts with multiple genes. Evidence for one of these interactions indicates that FANCD2, the interacting partner, and RAD18 form a complex... | |
medium_divergent_branch_03702 | MGRN1 is reported to interact with multiple proteins. One specific interaction is supported by evidence stating that the interacting entity co-immunoprecipitated with MCRs, suggesting a physical interaction. Which protein is encoded by the gene corresponding to this interacting entity? | Melanocyte-stimulating hormone receptor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03702","source_qa_id":"medium_divergent_branch_04309","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"MGRN1 is reported to interact with multiple proteins. One specific interaction is supported by ev... | |
medium_divergent_branch_03703 | SUPT7L interacts with multiple proteins. One specific interaction partner forms a heterodimer with TAF8 via its histone fold and proline-rich domains, interacts with SUPT7L through its C-terminal region, and together these three proteins form a complex both in vitro and in vivo. Which protein is this interaction partne... | Transcription initiation factor TFIID subunit 10 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03703","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SUPT7L interacts with multiple proteins. One specific interaction partner forms a heterodimer with TAF8 via its histone fold and proline-rich domains... | |
medium_divergent_branch_03704 | The LDLR gene has multiple interacting partners. One specific interaction is supported by evidence stating: 'We show that the interacting partner binds to the intracellular domain of some members of the low-density lipoprotein receptor (LDLR) family such as LDLR, VLDLR, ApoER2 and LDLR-related protein.' Which protein i... | Sorting nexin-17 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03704","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The LDLR gene has multiple interacting partners. One specific interaction is supported by evidence stating: 'We show that the interacting partner bin... | |
medium_divergent_branch_03705 | EIF2AK2 (PKR) interacts with multiple proteins. One interaction is supported by evidence stating: 'We show that PKR physically interacts with either Jak1 or the shared protein in unstimulated cells and that these interactions are increased in IFN-treated cells.' What is the full name of the protein encoded by the gene ... | Non-receptor tyrosine-protein kinase TYK2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03705","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EIF2AK2 (PKR) interacts with multiple proteins. One interaction is supported by evidence stating: 'We show that PKR physically interacts with either ... | |
medium_divergent_branch_03706 | The gene PPP6C is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'Here we report that DNA-PKcs interacts with the catalytic subunits of PP6 (PP6c) and PP2A (PP2Ac), as well as with the PP6 regulatory subunits PP6R1, PP6R2, and PP6R3.' Based on this evidence, which p... | Serine/threonine-protein phosphatase 6 regulatory subunit 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03706","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PPP6C is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'Here we report that DNA-PKcs ... | |
medium_divergent_branch_03707 | SH3KBP1 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we show that Sprouty2 associates with CIN85 and acts at the interface between Cbl and CIN85 to inhibit EGFR downregulation.' Which cell type is enriched for the gene identified by this evidence? | natural killer cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03707","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SH3KBP1 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we show that Sprouty2 associates with CIN85 and acts ... | |
medium_divergent_branch_03708 | TGFB1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Consistent with this hypothesis, we demonstrate that ALK1 in endothelial cells binds to TGF-beta1 and TbetaR-II.' Which protein, connected to TGFB1 via this binding interaction, is encoded by the gene in question? | TGF-beta receptor type-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03708","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TGFB1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Consistent with this hypothesis, we demonstrate that ALK1 ... | |
medium_divergent_branch_03710 | UBXN7 interacts with multiple genes. One of these interaction partners is characterized by a mechanism where the UIM motif in UBXN7 directly engages the modification of this partner on cullins. Which disease is associated with this specific interaction partner via a biomarker relationship? | breast carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03710","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBXN7 interacts with multiple genes. One of these interaction partners is characterized by a mechanism where the UIM motif in UBXN7 directly engages ... | |
medium_divergent_branch_03711 | The SRC gene has multiple interacting partners. One specific interaction is supported by evidence showing that Crn7 binds to the partner protein in vivo and can be phosphorylated by recombinant SRC in vitro. Which protein is encoded by the gene corresponding to this specific interacting partner? | Coronin-7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03711","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The SRC gene has multiple interacting partners. One specific interaction is supported by evidence showing that Crn7 binds to the partner protein in v... | |
medium_divergent_branch_03712 | ITGA2B is known to interact with multiple proteins. One specific interaction is supported by evidence stating that the interacting protein bound to αIIb in pull-down and coimmunoprecipitation assays. Which protein corresponds to this interacting partner? | Sharpin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03712","source_qa_id":"medium_divergent_branch_04625","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ITGA2B is known to interact with multiple proteins. One specific interaction is supported by evid... | |
medium_divergent_branch_03713 | FBXO25 interacts with multiple proteins. One interaction was characterized by investigating hFBX25's genomic organization and establishing it as an F-box protein (FBP) by verifying its interaction with Skp1 and the target protein. Which protein, encoded by the gene connected to FBXO25 via this specific interaction, is ... | Cullin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03713","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBXO25 interacts with multiple proteins. One interaction was characterized by investigating hFBX25's genomic organization and establishing it as an F... | |
medium_divergent_branch_03714 | RARA interacts with multiple proteins. One of these interaction partners is distinguished by experimental evidence showing that it forms a complex with RARalpha in both the absence and presence of retinoic acid (RA), a behavior that differentiates it from other corepressors. Which protein is this interaction partner? | Ski oncogene | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03714","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RARA interacts with multiple proteins. One of these interaction partners is distinguished by experimental evidence showing that it forms a complex wi... | |
medium_divergent_branch_03715 | ICAM1 interacts with multiple genes via binding relationships. One such interaction is supported by evidence stating: 'Interactions of cell-adhesion molecule [Protein X] and its ligand ICAM-1 play important roles during immune and inflammatory responses.' Which protein is encoded by the gene connected to ICAM1 through ... | Integrin alpha-L | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03715","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ICAM1 interacts with multiple genes via binding relationships. One such interaction is supported by evidence stating: 'Interactions of cell-adhesion ... | |
medium_divergent_branch_03716 | The gene PPP1R13L interacts with multiple partners. One specific interaction is supported by evidence stating: 'We found that iASPP associates with centrosomal protein of 55 kDa, an important cytokinetic abscission regulator.' Which disease is associated with this interaction partner through genomic alterations? | multinucleated neurons-anhydramnios-renal dysplasia-cerebellar hypoplasia-hydranencephaly syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03716","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PPP1R13L interacts with multiple partners. One specific interaction is supported by evidence stating: 'We found that iASPP associates with c... | |
medium_divergent_branch_03717 | AMBRA1 interacts with multiple proteins. One specific interaction is described as follows: 'In this study, we show that the BECLIN 1-VPS34 complex is tethered to the cytoskeleton through an interaction between the BECLIN 1-interacting protein AMBRA1 and dynein light chains 1/2.' Based on this description, identify the ... | breast cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03717","source_qa_id":"medium_divergent_branch_01948","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"AMBRA1 interacts with multiple proteins. One specific interaction is described as follows: 'In th... | |
medium_divergent_branch_03718 | LGALS9 is associated with multiple biological processes. One specific association is supported by evidence stating that Galectin-9, a tandem repeat lectin involved in immune modulation, is expressed in the endometrium during the mid and late secretory phases and in the decidua during human early pregnancy. Based on thi... | gravid organism | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03718","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LGALS9 is associated with multiple biological processes. One specific association is supported by evidence stating that Galectin-9, a tandem repeat l... | |
medium_divergent_branch_03719 | The protein MDFI interacts with multiple partners. One specific interaction is described by the evidence: 'I-mf associates with MyoD family members and retains them in the cytoplasm by masking their nuclear localization signals.' Identify the gene corresponding to this specific interaction partner, and then determine w... | TCF3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03719","source_qa_id":"medium_divergent_branch_01929","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The protein MDFI interacts with multiple partners. One specific interaction is described by the e... | |
medium_divergent_branch_03720 | CD27 is associated with multiple biological processes. One specific association is supported by evidence stating that CD27, as a member of the TNFR family, causes B cells to differentiate into antibody-forming cells with marginal effects on proliferation. Which broader biological category is the process linked to this ... | B cell mediated immunity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03720","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CD27 is associated with multiple biological processes. One specific association is supported by evidence stating that CD27, as a member of the TNFR f... | |
medium_divergent_branch_03721 | The gene CERCAM is enriched in multiple cell types. One specific enrichment profile is characterized by a mean expression of 2.71 TPM, a z-score of 1.59, and a fold enrichment of 2.71. Identify the cell type associated with this specific expression profile, and then determine the cell type from which it develops. | mature CD8 single-positive thymocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03721","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CERCAM is enriched in multiple cell types. One specific enrichment profile is characterized by a mean expression of 2.71 TPM, a z-score of 1... | |
medium_divergent_branch_03722 | The gene PRKDC interacts with multiple partners. One specific partner is characterized by localization to cytoplasmic vesicles and the plasma membrane, and it physically interacts with the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs). Which protein is encoded by this specific partner gene? | E3 ubiquitin-protein ligase RNF144A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03722","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PRKDC interacts with multiple partners. One specific partner is characterized by localization to cytoplasmic vesicles and the plasma membran... | |
medium_divergent_branch_03723 | The UNKL gene interacts with multiple partners. One specific interaction is supported by evidence stating: 'Using two-hybrid cloning procedures, we identified a mammalian RING finger protein homologous to drosophila Unkempt as a new partner of the activated form of RacGTPases and demonstrated that mammalian Unkempt spe... | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03723","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The UNKL gene interacts with multiple partners. One specific interaction is supported by evidence stating: 'Using two-hybrid cloning procedures, we i... | |
medium_divergent_branch_03724 | CLNS1A interacts with multiple proteins. One interaction is described in the context of a large (20 S) protein arginine methyltransferase complex, termed the methylosome, which contains the methyltransferase JBP1 and the pICln protein. Which protein, encoded by the gene linked to CLNS1A via this specific interaction, i... | Protein arginine N-methyltransferase 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03724","source_qa_id":"medium_divergent_branch_00695","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"CLNS1A interacts with multiple proteins. One interaction is described in the context of a large (... | |
medium_divergent_branch_03725 | The gene FOXJ2 is associated with multiple biological processes. One specific association is supported by evidence stating that 'Foxj2 overexpression attenuated endothelial differentiation of EPCs, while Foxj2 siRNA had the opposite effect.' Identify the biological process linked to FOXJ2 via this specific evidence, an... | blood vessel endothelial cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03725","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene FOXJ2 is associated with multiple biological processes. One specific association is supported by evidence stating that 'Foxj2 overexpression... | |
medium_divergent_branch_03726 | HDAC3 interacts with multiple proteins. One specific interaction is characterized by the following evidence: 'The HDAC activity of the protein in question maps to a carboxyl-terminal domain and is dependent on the interaction with the class I HDAC, HDAC3, in the cell nucleus.' Which protein, connected to HDAC3 via this... | Histone deacetylase 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03726","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HDAC3 interacts with multiple proteins. One specific interaction is characterized by the following evidence: 'The HDAC activity of the protein in que... | |
medium_divergent_branch_03727 | TBK1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study, we purified and characterized a novel kinase (T2K, also known as TBK1 or NAK), which associates with a specific protein and exhibits kinase activity towards I-kappaBalpha in vitro.' Which protein is encoded by the g... | TNF receptor-associated factor 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03727","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TBK1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study, we purified and characterized a novel kinase... | |
medium_divergent_branch_03728 | UBQLN4 interacts with multiple proteins. One of these interaction partners is described in the literature as a binding factor for UBQLN4 that eliminates newly synthesized defective polypeptides. Which protein, among the interactors of UBQLN4, is encoded by the gene corresponding to this specific functional description? | Large proline-rich protein BAG6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03728","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBQLN4 interacts with multiple proteins. One of these interaction partners is described in the literature as a binding factor for UBQLN4 that elimina... | |
medium_divergent_branch_03729 | The gene ACTG1 interacts with multiple partners. One specific interaction is supported by evidence stating: 'We characterized in detail the actin binding site of the small actin-sequestering protein thymosin beta 4 (T beta 4) using chemically synthesized full-length T beta 4 variants.' Which gene, connected to ACTG1 vi... | TMSB10 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03729","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ACTG1 interacts with multiple partners. One specific interaction is supported by evidence stating: 'We characterized in detail the actin bin... | |
medium_divergent_branch_03731 | PODXL interacts with multiple genes. One interaction is supported by evidence stating: 'The cytoplasmic tail of PC contains a C-terminal PDZ-binding motif (DTHL) that binds to the second PDZ domain of this interaction partner in yeast two-hybrid and in vitro pull-down assays.' Which disease is associated with this inte... | aplasia cutis congenita | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03731","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PODXL interacts with multiple genes. One interaction is supported by evidence stating: 'The cytoplasmic tail of PC contains a C-terminal PDZ-binding ... | |
medium_divergent_branch_03733 | Renal water absorption is associated with multiple anatomical structures. One such structure is described by the evidence: 'The S2 portion of the tubule is involved in reabsorption of water and sodium chloride.' Which anatomical structure, connected to this specific tubular segment via an 'is a' relationship, is the co... | excretory tube | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03733","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Renal water absorption is associated with multiple anatomical structures. One such structure is described by the evidence: 'The S2 portion of the tub... | |
medium_divergent_branch_03735 | Acetylcholine interacts with multiple drugs. One such drug is characterized by evidence stating: 'Furthermore, prevention of methacholine- and acetylcholine-induced bronchoconstrictive effects was dose dependent and lasted longer than 24 hours, demonstrating a long duration of action.' Which disease is this drug indica... | chronic obstructive pulmonary disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03735","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Acetylcholine interacts with multiple drugs. One such drug is characterized by evidence stating: 'Furthermore, prevention of methacholine- and acetyl... | |
medium_divergent_branch_03736 | ERCC8 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that a unique CSA mutant (W361C), which was previously identified in a patient with UV(s)S syndrome, showed defective binding to a partner protein and resulted in a failure of recruiting this partner protein and stabiliz... | UV-sensitive syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03736","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ERCC8 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that a unique CSA mutant (W361C), which was previ... | |
medium_divergent_branch_03737 | Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 4.813 and an adjusted p-value of 0.0206. Which protein does that selected gene encode? | DNA-binding protein inhibitor ID-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03737","source_qa_id":"medium_divergent_branch_04501","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fo... | |
medium_divergent_branch_03738 | PPIA interacts with multiple genes. One of these interacting partners was shown to co-immunoprecipitate with CypA in vivo in breast epithelial T47D cells and in Chinese hamster ovary cells overexpressing the human protein. Which disease is associated with genomic alterations in this specific interacting partner? | breast benign neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03738","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PPIA interacts with multiple genes. One of these interacting partners was shown to co-immunoprecipitate with CypA in vivo in breast epithelial T47D c... | |
medium_divergent_branch_03739 | Interleukin-4 production is enabled by more than one cell type. One of these cell types is described as a fully differentiated basophil, a granular leukocyte with an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse granules of variable size.... | band form basophil | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03739","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Interleukin-4 production is enabled by more than one cell type. One of these cell types is described as a fully differentiated basophil, a granular l... | |
medium_divergent_branch_03740 | EBNA1BP2 interacts with multiple genes. One of these interaction partners was identified as a nucleolar binding protein (NoBP) that coimmunoprecipitated and colocalized with the partner in transfected COS-1 cells, as determined by the yeast two-hybrid system. Which disease is associated with this specific interaction p... | diabetic retinopathy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03740","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EBNA1BP2 interacts with multiple genes. One of these interaction partners was identified as a nucleolar binding protein (NoBP) that coimmunoprecipita... | |
medium_divergent_branch_03743 | CD80 is known to bind to multiple gene products. One specific interaction is supported by evidence stating: 'We have identified, by site-directed mutagenesis of soluble forms of CD80 and CD86, residues in both the IgV and IgC domains that are important for CTLA4Ig and CD28Ig binding.' Based on this structural evidence,... | PPP2R5A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03743","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CD80 is known to bind to multiple gene products. One specific interaction is supported by evidence stating: 'We have identified, by site-directed mut... | |
medium_divergent_branch_03744 | ZNF346 interacts with multiple proteins. One of these interaction partners is known to bind JAZ in an RNA-independent manner, a process that specifically requires the double-stranded RNA binding domains of that partner. Which protein, encoded by the gene connected to ZNF346 via this specific interaction, is being descr... | Interleukin enhancer-binding factor 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03744","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZNF346 interacts with multiple proteins. One of these interaction partners is known to bind JAZ in an RNA-independent manner, a process that specific... |
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