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medium_divergent_branch_03856 | ATP2A2 interacts with multiple proteins. One of these interaction partners is reported to interact with SERCA and prevent the formation of the SERCA/PLN/SLN inhibitory complex. Which protein is encoded by the gene corresponding to this specific interaction partner? | Vacuole membrane protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03856","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATP2A2 interacts with multiple proteins. One of these interaction partners is reported to interact with SERCA and prevent the formation of the SERCA/... | |
medium_divergent_branch_03857 | MIR181C is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence that miR-181c acts as a negative regulator modulating the activation of CD4(+) T cells. Which biological process is the target of the 'negatively regulates' relationship origina... | T cell activation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03857","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR181C is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence that m... | |
medium_divergent_branch_03858 | The gene ATXN1 interacts with multiple partners. One specific interaction is supported by evidence stating that a specific ubiquitin-conjugating enzyme interacts with and ubiquitinates ataxin-1, the protein product of the spinocerebellar ataxia type 1 gene. Which protein is encoded by the gene corresponding to this spe... | Ubiquitin-conjugating enzyme E2 E1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03858","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ATXN1 interacts with multiple partners. One specific interaction is supported by evidence stating that a specific ubiquitin-conjugating enzy... | |
medium_divergent_branch_03859 | PKN2 interacts with multiple proteins. One specific interaction is mediated by the PDZ3 domain of a protein tyrosine phosphatase and the extreme C-terminus of PRK2, as demonstrated by yeast two-hybrid assays and coimmunoprecipitation experiments in transfected HeLa cells. Which protein corresponds to this described int... | Tyrosine-protein phosphatase non-receptor type 13 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03859","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PKN2 interacts with multiple proteins. One specific interaction is mediated by the PDZ3 domain of a protein tyrosine phosphatase and the extreme C-te... | |
medium_divergent_branch_03860 | Thymine DNA glycosylase (TDG) interacts with multiple genes. One interaction is supported by evidence stating: 'Two-hybrid screening in yeast with p73alpha isolated [a small ubiquitin-like modifier protein], the enzyme responsible for its conjugation, Ubc-9, and a number of novel [small ubiquitin-like modifier protein]... | melanoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03860","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Thymine DNA glycosylase (TDG) interacts with multiple genes. One interaction is supported by evidence stating: 'Two-hybrid screening in yeast with p7... | |
medium_divergent_branch_03861 | GIPC1 interacts with multiple proteins. One specific interaction is characterized by a mechanism wherein engagement of the GIPC/synectin PDZ domain by the C termini of internalized receptors facilitates, in trans, the binding of this interaction partner to the GIPC/synectin C terminus located outside of the PDZ domain.... | retinal degeneration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03861","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GIPC1 interacts with multiple proteins. One specific interaction is characterized by a mechanism wherein engagement of the GIPC/synectin PDZ domain b... | |
medium_divergent_branch_03862 | ARID1B interacts with multiple genes. One of these interaction partners is described in evidence stating that BAF250b contains a BC box motif, associates with EloC in a BC box-dependent manner, and, together with a cullin family member and Roc1, assembles into an E3 ubiquitin ligase. Which disease is connected to this ... | malignant colon neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03862","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARID1B interacts with multiple genes. One of these interaction partners is described in evidence stating that BAF250b contains a BC box motif, associ... | |
medium_divergent_branch_03863 | ELF4 is associated with multiple biological processes. One association is supported by evidence that ELF4 restrains inflammation and protects against mucosal disease. Which biological process is negatively regulated by the process linked to this specific evidence? | inflammatory response | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03863","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ELF4 is associated with multiple biological processes. One association is supported by evidence that ELF4 restrains inflammation and protects against... | |
medium_divergent_branch_03864 | MAP3K2 interacts with multiple proteins. One of these interaction partners is known to interact with and ubiquitinate MEKK2, a kinase associated with bi-phasic NF-kappaB activation. Which protein, encoded by the gene connected to MAP3K2 via this specific interaction, is the subject of this description? | E3 ubiquitin-protein ligase XIAP | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03864","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP3K2 interacts with multiple proteins. One of these interaction partners is known to interact with and ubiquitinate MEKK2, a kinase associated with... | |
medium_divergent_branch_03865 | PRPF19 interacts with multiple genes. One of these interacting partners is identified in evidence stating: 'Further study has revealed that a kinase-interacting protein scaffold interacts with Pre-mRNA processing Factor 19 (Prp19).' Which disease is associated with the gene identified in this evidence? | combined immunodeficiency with faciooculoskeletal anomalies | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03865","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRPF19 interacts with multiple genes. One of these interacting partners is identified in evidence stating: 'Further study has revealed that a kinase-... | |
medium_divergent_branch_03866 | The gene ADRB2 interacts with multiple other genes. One specific interaction is supported by evidence stating: 'The Na+/H+ exchanger regulatory factor (NHERF) binds to the tail of the beta2-adrenergic receptor and plays a role in adrenergic regulation of Na+/H+ exchange.' Which protein is encoded by the gene that inter... | Na(+)/H(+) exchange regulatory cofactor NHE-RF2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03866","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ADRB2 interacts with multiple other genes. One specific interaction is supported by evidence stating: 'The Na+/H+ exchanger regulatory facto... | |
medium_divergent_branch_03867 | DDIT3 interacts with multiple proteins. One interaction partner is described as a mammalian tribbles homolog that functions as a repressor of CHOP, interacting with CHOP via its N-terminal portion and blocking the association of p300 with CHOP. Which protein is encoded by the gene corresponding to this specific interac... | Tribbles homolog 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03867","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DDIT3 interacts with multiple proteins. One interaction partner is described as a mammalian tribbles homolog that functions as a repressor of CHOP, i... | |
medium_divergent_branch_03868 | BCL10 is involved in multiple biological processes. One specific process is supported by evidence stating: 'A recent study reveals that the Bcl10-Malt1 complex promotes mast-cell interleukin-6 and tumor necrosis factor production, independent of degranulation, eicosanoid secretion or survival.' Identify the biological ... | mast cell cytokine production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03868","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BCL10 is involved in multiple biological processes. One specific process is supported by evidence stating: 'A recent study reveals that the Bcl10-Mal... | |
medium_divergent_branch_03869 | BCL9 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we identify four conserved residues at the putative PHD domain surface of Drosophila and mouse Pygopus that are required for their binding to Legless in vitro and in vivo.' Which protein is encoded by the gene corresponding ... | Pygopus homolog 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03869","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BCL9 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we identify four conserved residues at the putative P... | |
medium_divergent_branch_03870 | MIR20B is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence showing that knockdown of hsa-miR-20b attenuated premature senescence in TNF-α-treated HMVEC-Ls, resulting in increased cell proliferation, increased RBL1 mRNA expression, and de... | vascular endothelial cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03870","source_qa_id":"medium_divergent_branch_07141","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"MIR20B is associated with multiple biological processes via the 'involved in' relationship. One s... | |
medium_divergent_branch_03871 | The protein INAVA is involved in multiple biological processes. One specific process is supported by evidence stating that upon PRR stimulation, INAVA is required for optimal MAPK and NF-κB activation, cytokine secretion, and intracellular bacterial clearance. Which biological process is positively regulated by this sp... | cytokine production involved in immune response | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03871","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein INAVA is involved in multiple biological processes. One specific process is supported by evidence stating that upon PRR stimulation, INAV... | |
medium_divergent_branch_03872 | RNF34 interacts with multiple proteins. One interaction is supported by evidence stating: 'We have isolated a family of apoptotic inhibitors [caspases-8- and -10-associated RING proteins (CARPs)] that bind to and negatively regulate DED caspases.' Which protein is encoded by the gene that interacts with RNF34 in this s... | Caspase-10 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03872","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF34 interacts with multiple proteins. One interaction is supported by evidence stating: 'We have isolated a family of apoptotic inhibitors [caspase... | |
medium_divergent_branch_03873 | PRKAR1A interacts with multiple proteins. One of these interaction partners is described as forming a stable complex with and being phosphorylated by PKA. Which protein corresponds to this interaction partner? | E3 ubiquitin-protein ligase Praja-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03873","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRKAR1A interacts with multiple proteins. One of these interaction partners is described as forming a stable complex with and being phosphorylated by... | |
medium_divergent_branch_03874 | ATM interacts with multiple proteins. One interaction is supported by evidence that TLR3 pathway stimulation induced ATM phosphorylation and promoted its interaction with a MAP3K7 family member, NEMO, IKKα, and IKKβ. Which protein, connected to ATM via this specific interaction evidence, is encoded by the gene in quest... | Mitogen-activated protein kinase kinase kinase 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03874","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATM interacts with multiple proteins. One interaction is supported by evidence that TLR3 pathway stimulation induced ATM phosphorylation and promoted... | |
medium_divergent_branch_03875 | EPS15 interacts with multiple proteins. One such interacting partner is described in the evidence as 'a protein known to be involved in endocytosis and the control of cell proliferation.' Which disease is associated with this specific interacting partner? | infectious mononucleosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03875","source_qa_id":"medium_divergent_branch_07322","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"EPS15 interacts with multiple proteins. One such interacting partner is described in the evidence... | |
medium_divergent_branch_03876 | DISC1 interacts with multiple genes. One specific interaction is characterized by structural evidence showing the partner protein bound to the DISC1 phosphodegron motif, where disruption of this complex leads to DISC1 stabilization. Which disease is associated with this specific interacting partner via a biomarker rela... | glioblastoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03876","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DISC1 interacts with multiple genes. One specific interaction is characterized by structural evidence showing the partner protein bound to the DISC1 ... | |
medium_divergent_branch_03877 | APC2 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating: 'Antibodies against the NH2 terminus of human APC2 show that endogenous APC2 is diffusely distributed in the cytoplasm and colocalizes with both the Golgi apparatus and acti... | polymeric cytoskeletal fiber | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03877","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"APC2 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating: 'A... | |
medium_divergent_branch_03878 | SOX2 is associated with multiple biological processes. One specific association is supported by evidence stating that SOX2 is expressed throughout the human brain, including the developing hypothalamus, as well as Rathke's pouch, the developing anterior pituitary, and the eye. Which biological process is a parent term ... | gland development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03878","source_qa_id":"medium_divergent_branch_03834","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"SOX2 is associated with multiple biological processes. One specific association is supported by e... | |
medium_divergent_branch_03880 | MARCH7 interacts with multiple genes. One interaction is supported by evidence stating that a nephrocystin protein directly binds to a deubiquitinating enzyme (FAM) and two E3 ubiquitin ligases: BBS11 (TRIM32) and the interaction partner known as axotrophin. Which disease is connected to this interaction partner throug... | Leber congenital amaurosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03880","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MARCH7 interacts with multiple genes. One interaction is supported by evidence stating that a nephrocystin protein directly binds to a deubiquitinati... | |
medium_divergent_branch_03881 | The gene GPR65 is enriched in multiple cell types. One specific cell type shows a mean expression of 51.88 TPM, a z-score of 1.57, and a fold enrichment of 2.65 for this gene. Which cell type is the developmental precursor of the cell type exhibiting these specific expression statistics? | pro-NK cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03881","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene GPR65 is enriched in multiple cell types. One specific cell type shows a mean expression of 51.88 TPM, a z-score of 1.57, and a fold enrichm... | |
medium_divergent_branch_03882 | Rift Valley fever phlebovirus downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -2.182 and an adjusted p-value of 0.000209. Which disease has a genomic-alteration link with that selected gene? | Crohn disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03882","source_qa_id":"medium_divergent_branch_04757","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Rift Valley fever phlebovirus downregulates several genes. In the recorded experiment, one bra... | |
medium_divergent_branch_03883 | FGF2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Direct binding experiments with radiolabeled acidic FGF (aFGF) or basic FGF (bFGF), inhibition of binding with native growth factors, and Scatchard analysis of the binding data indicated that a specific receptor and flg bind eithe... | Fibroblast growth factor receptor 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03883","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FGF2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Direct binding experiments with radiolabeled acidic FGF (aF... | |
medium_divergent_branch_03884 | NFKB1 interacts with multiple genes. One interaction is supported by evidence stating: 'Immunoprecipitation experiments showed that the TAN-1 from a T cell line is associated with NF-kappa B containing p50 and p65 subunits.' Which disease is causally linked to the gene identified by this specific evidence? | papillary adenocarcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03884","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NFKB1 interacts with multiple genes. One interaction is supported by evidence stating: 'Immunoprecipitation experiments showed that the TAN-1 from a ... | |
medium_divergent_branch_03885 | GRID2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we have identified protein interactions between GluRdelta2, a novel isoform of a PDZ domain-containing protein (nPIST) that binds to this receptor, and Beclin1.' Which protein, connected to GRID2 via an interaction, is the s... | Golgi-associated PDZ and coiled-coil motif-containing protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03885","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GRID2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we have identified protein interactions between GluRd... | |
medium_divergent_branch_03886 | RHOB interacts with multiple proteins. One interaction is supported by evidence stating: 'By yeast two-hybrid screenings and coimmunoprecipitation, we show here that p76RBE is a specific binding protein of RHOB and binds selectively to the GTP-bound form of this small GTPase.' Which protein, connected to RHOB via a bin... | Rhophilin-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03886","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RHOB interacts with multiple proteins. One interaction is supported by evidence stating: 'By yeast two-hybrid screenings and coimmunoprecipitation, w... | |
medium_divergent_branch_03887 | PIP5K1C interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that the predominant brain splice variant of PtdInsPKI gamma (PtdInsPKI gamma-90) binds, by means of a short carboxy-terminal peptide, to the FERM domain of talin, and is strongly activated by this interaction.' Wh... | Talin-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03887","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PIP5K1C interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that the predominant brain splice variant o... | |
medium_divergent_branch_03888 | FOXH1 interacts with multiple proteins. One of these interaction partners is a cytoplasmic protein that translocates to the nucleus in response to TGF-beta signaling. This protein forms a multimeric complex with FOXH1 and another partner on the activin response element, which serves as a high-affinity binding site for ... | SMAD family member 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03888","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FOXH1 interacts with multiple proteins. One of these interaction partners is a cytoplasmic protein that translocates to the nucleus in response to TG... | |
medium_divergent_branch_03889 | CFLAR interacts with multiple proteins. One of these interaction partners is reported to bind Casper, caspase-8, caspase-3, TRAF1, and TRAF2 through distinct domains. Which protein, connected to CFLAR via a binding interaction, is encoded by the gene in question? | FAS-associated death domain protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03889","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CFLAR interacts with multiple proteins. One of these interaction partners is reported to bind Casper, caspase-8, caspase-3, TRAF1, and TRAF2 through ... | |
medium_divergent_branch_03890 | HDAC4 interacts with multiple proteins. One interaction partner is described as repressing MEF2 transcriptional activity by binding to MEF2 and catalyzing local histone deacetylation. Which disease is associated with this specific interaction partner? | myxoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03890","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HDAC4 interacts with multiple proteins. One interaction partner is described as repressing MEF2 transcriptional activity by binding to MEF2 and catal... | |
medium_divergent_branch_03891 | The gene GRIN2A interacts with multiple partners. One specific interaction is supported by evidence stating: 'Coimmunoprecipitation analysis showed that NR3B could form NMDA receptor complex with NR1a and NR2A subunits in heterologous cells.' Identify the protein product encoded by the gene that corresponds to the NR3B... | Glutamate receptor ionotropic, NMDA 3B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03891","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene GRIN2A interacts with multiple partners. One specific interaction is supported by evidence stating: 'Coimmunoprecipitation analysis showed t... | |
medium_divergent_branch_03892 | The hair follicle placode develops from a specific anatomical structure described as a bud-like thickening in the epidermis consisting of elongated keratinocytes, which at the distal end are in touch with numerous aggregated specialized dermal fibroblasts (the dermal condensate). Which anatomical entity is this precurs... | integument | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03892","source_qa_id":"medium_divergent_branch_03414","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The hair follicle placode develops from a specific anatomical structure described as a bud-like t... | |
medium_divergent_branch_03893 | The protein IL17F is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence stating: 'However, it markedly inhibited the angiogenesis of human endothelial cells and induced endothelial cells to produce IL-2, TGF-beta, and monocyte chemoattract... | cytokine production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03893","source_qa_id":"medium_divergent_branch_07061","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The protein IL17F is associated with multiple biological processes via the 'involved in' relation... | |
medium_divergent_branch_03894 | SMG1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We identified SMG-8 and SMG-9 as novel subunits of the SMG-1 complex.' Which protein, connected to SMG1 via this specific interaction, is encoded by the gene in question? | Nonsense-mediated mRNA decay factor SMG9 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03894","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMG1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We identified SMG-8 and SMG-9 as novel subunits of the SMG-... | |
medium_divergent_branch_03895 | MDH2 interacts with multiple genes. One interaction is supported by evidence stating: 'Mechanistically, we found that MDHDH directly bound to MDH2 and [the interacting partner] (20S proteasomal core subunit alpha-type 1) as a molecular scaffold and accelerated the degradation of MDH2 by promoting the binding of ubiquit... | human papilloma virus infection | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03895","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MDH2 interacts with multiple genes. One interaction is supported by evidence stating: 'Mechanistically, we found that MDHDH directly bound to MDH2 an... | |
medium_divergent_branch_03896 | SIRT2 interacts with multiple proteins. One specific interaction is supported by evidence stating that CBP/SIRT2 interacted with the target protein and acetylated/deacetylated its K431 residue. Which protein, connected to SIRT2 via an interaction, is encoded by the gene in question? | BAG family molecular chaperone regulator 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03896","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SIRT2 interacts with multiple proteins. One specific interaction is supported by evidence stating that CBP/SIRT2 interacted with the target protein a... | |
medium_divergent_branch_03897 | LEF1 is associated with multiple biological processes. One association is supported by evidence stating: 'The introduction of LEF-1 into developing Th2 cells resulted in the suppression of Th2 cytokine production.' Identify the biological process that is negatively regulated by the process linked to LEF1 via this speci... | interleukin-4 production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03897","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LEF1 is associated with multiple biological processes. One association is supported by evidence stating: 'The introduction of LEF-1 into developing T... | |
medium_divergent_branch_03898 | Anastrozole interacts with multiple compounds. One specific interaction is supported by evidence stating: 'Regardless of cell lines, T slightly decreased STS activity after direct incubation, but led to an increase of local estrogen formation after 24h which was attenuated, and partly reversed by A, respectively.' Iden... | postmenopausal osteoporosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03898","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Anastrozole interacts with multiple compounds. One specific interaction is supported by evidence stating: 'Regardless of cell lines, T slightly decre... | |
medium_divergent_branch_03899 | DDX20 interacts with multiple proteins. One interaction is supported by evidence stating: 'With the help of a yeast two-hybrid screen we found that αB-crystallin can interact with the C-terminal part of Gemin3 and confirmed this interaction by co-immunoprecipitation.' Which protein is encoded by the gene corresponding ... | Alpha-crystallin B chain | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03899","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DDX20 interacts with multiple proteins. One interaction is supported by evidence stating: 'With the help of a yeast two-hybrid screen we found that α... | |
medium_divergent_branch_03901 | FOXP1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'we demonstrated that FOXP1 promotes the expansion of primary mature human B cells by inhibiting caspase-dependent apoptosis, without affecting B-cell proliferation.' Which biological process is negatively... | B cell apoptotic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03901","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FOXP1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'we demonstrated that FOXP1 promot... | |
medium_divergent_branch_03902 | ITGB3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Co-immunoprecipitation assay showed that OSS induces sustained increases in association of a signaling adaptor protein and FAK with alpha(v)beta(3) and beta(1) integrins and PI3K subunit p85, which were abolished by transfecting ... | plasma membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03902","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ITGB3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Co-immunoprecipitation assay showed that OSS induces susta... | |
medium_divergent_branch_03903 | TERF2IP interacts with multiple proteins. One specific interaction is supported by evidence stating that 'Co-immunoprecipitation, Far-Western assays, and two-hybrid assays showed that the protein encoded by the selected gene, but not POT1 or PIP1, interacts directly with TRF2.' Which protein, connected to TERF2IP via t... | TERF1-interacting nuclear factor 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03903","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TERF2IP interacts with multiple proteins. One specific interaction is supported by evidence stating that 'Co-immunoprecipitation, Far-Western assays,... | |
medium_divergent_branch_03904 | MIR26A1 is associated with multiple biological processes. One association is supported by evidence that overexpression of miR-26a leads to reduced expression of Th17-related cytokines. Which biological process, connected to this specific process via a 'negatively regulates' relationship, is the target of this regulatio... | interleukin-17 production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03904","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR26A1 is associated with multiple biological processes. One association is supported by evidence that overexpression of miR-26a leads to reduced ex... | |
medium_divergent_branch_03905 | Human mastadenovirus C downregulates multiple genes. One specific downregulation event is characterized by a log2 fold change of -1.687 and an adjusted p-value of 0.03499. Which gene is the target of this specific downregulation event, and what gene does that target interact with? | REP15 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03905","source_qa_id":"medium_divergent_branch_06363","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"Human mastadenovirus C downregulates multiple genes. One specific downregulation event is charact... | |
medium_divergent_branch_03906 | ZPR1 is involved in multiple biological processes. One of these processes is supported by evidence that ZPR1 is required for the localization of SMN in nuclear bodies. Which biological process is positively regulated by this specific ZPR1-associated process? | protein import into nucleus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03906","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZPR1 is involved in multiple biological processes. One of these processes is supported by evidence that ZPR1 is required for the localization of SMN ... | |
medium_divergent_branch_03907 | SORBS3 interacts with multiple genes. One interaction is supported by evidence stating: 'We identified the cytoskeletal molecule vinexin as a partner interacting with SOCS-7.' Which protein is encoded by the gene connected to SORBS3 via this specific interaction? | Suppressor of cytokine signaling 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03907","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SORBS3 interacts with multiple genes. One interaction is supported by evidence stating: 'We identified the cytoskeletal molecule vinexin as a partner... | |
medium_divergent_branch_03908 | The biological process 'positive regulation of neurotransmitter secretion' is defined as any process that activates or increases the frequency, rate, or extent of the regulated release of a neurotransmitter. This process is a subtype of a broader biological process. Which biological process is positively regulated by t... | secretion by cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03908","source_qa_id":"medium_divergent_branch_06971","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'positive regulation of neurotransmitter secretion' is defined as any proc... | |
medium_divergent_branch_03909 | MAP3K3 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Interestingly, we also find that a kinase and MEKK3 form a functional complex, in which the kinase regulates autophosphorylation of MEKK3.' Which disease is associated with the gene identified by this evidence through gen... | cardiospondylocarpofacial syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03909","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP3K3 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Interestingly, we also find that a kinase and MEKK... | |
medium_divergent_branch_03910 | The gene WWC1 interacts with multiple partners. One specific interaction is supported by evidence stating: 'Here we report that non-receptor tyrosine phosphatase 14 interacts with the Kibra protein.' Which disease is associated with this interaction partner? | lymphedema-posterior choanal atresia syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03910","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene WWC1 interacts with multiple partners. One specific interaction is supported by evidence stating: 'Here we report that non-receptor tyrosine... | |
medium_divergent_branch_03911 | ARL1 is known to interact with multiple proteins. One specific interaction involves ARL1-GTP binding to the GRIP domains of Golgin-97 and Golgin-245, a process that relies on conserved residues within these GRIP domains essential for Golgi targeting. Which protein, encoded by a gene that interacts with ARL1, is associa... | GRIP and coiled-coil domain-containing protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03911","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARL1 is known to interact with multiple proteins. One specific interaction involves ARL1-GTP binding to the GRIP domains of Golgin-97 and Golgin-245,... | |
medium_divergent_branch_03912 | The gene ADRA2A is associated with multiple biological processes. One specific association is supported by evidence describing a study on transgenic mice overexpressing the human alpha2A-adrenoceptor in pancreatic beta cells to investigate its role in regulating insulin secretion and maintaining a specific physiologica... | carbohydrate homeostasis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03912","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ADRA2A is associated with multiple biological processes. One specific association is supported by evidence describing a study on transgenic ... | |
medium_divergent_branch_03913 | RAD23B interacts with multiple genes. One of these interaction partners is supported by evidence stating that HHR23A binds a ubiquitin ligase and is ubiquitinated in vitro in a ligase-dependent manner. Which cell type is enriched in the gene corresponding to this specific interaction evidence? | natural killer cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03913","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAD23B interacts with multiple genes. One of these interaction partners is supported by evidence stating that HHR23A binds a ubiquitin ligase and is ... | |
medium_divergent_branch_03914 | GLB1 interacts with multiple genes via binding relationships. One specific interaction is supported by evidence stating that lysosomal neuraminidase and beta-galactosidase are present in a complex together with a 32-kDa protective protein. Which protein is encoded by the gene involved in this specific interaction? | Sialidase-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03914","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GLB1 interacts with multiple genes via binding relationships. One specific interaction is supported by evidence stating that lysosomal neuraminidase ... | |
medium_divergent_branch_03915 | MXD4 interacts with multiple genes. One of these interactions is supported by evidence stating: 'In this study, the human MAD4 was identified to interact with this partner by a yeast two-hybrid screen.' Which cellular component is this interaction partner located in? | nucleus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03915","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MXD4 interacts with multiple genes. One of these interactions is supported by evidence stating: 'In this study, the human MAD4 was identified to inte... | |
medium_divergent_branch_03916 | BAP1 interacts with multiple proteins. One specific interaction involves a cell-cycle regulator composed of HCF-1N and HCF-1C subunits, which is critical for BAP1-mediated growth regulation. Which disease is associated with this specific interacting protein? | methylmalonic acidemia with homocystinuria, type cblX | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03916","source_qa_id":"medium_divergent_branch_00531","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"BAP1 interacts with multiple proteins. One specific interaction involves a cell-cycle regulator c... | |
medium_divergent_branch_03917 | A specific gene interacts with multiple partners. Experimental evidence from GST pull-down and yeast two-hybrid assays indicates that the protein hNOT3L associates with TIP120B but not with TIP120A. Based on this evidence, identify the gene that encodes the protein hNOT3L. | CCR4-NOT transcription complex subunit 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03917","source_qa_id":"medium_divergent_branch_05941","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"A specific gene interacts with multiple partners. Experimental evidence from GST pull-down and ye... | |
medium_divergent_branch_03918 | FGF7 is associated with multiple biological processes. One association is supported by evidence that KGF induces keratinocyte motility and cytoskeletal rearrangement. Which biological process is positively regulated by the process linked to this specific evidence? | keratinocyte migration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03918","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FGF7 is associated with multiple biological processes. One association is supported by evidence that KGF induces keratinocyte motility and cytoskelet... | |
medium_divergent_branch_03919 | DSC1 interacts with multiple genes. One specific interaction is supported by coimmunoprecipitation experiments using cell lysates stably expressing the partner protein with anti-Dsc or -Dsg antibodies, which demonstrate that the desmosomal cadherins, the partner protein, and Dsc1a are involved in a direct Ca2+-dependen... | familial dilated cardiomyopathy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03919","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DSC1 interacts with multiple genes. One specific interaction is supported by coimmunoprecipitation experiments using cell lysates stably expressing t... | |
medium_divergent_branch_03920 | RAD21 interacts with multiple genes. One specific interaction is supported by evidence stating: 'We show that the hRAD21 subunit of the cohesin complex directly interacts with the ATPase subunit SNF2h.' Identify the disease associated with the gene described in this evidence through a biomarker relationship. | hepatitis B virus infection | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03920","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAD21 interacts with multiple genes. One specific interaction is supported by evidence stating: 'We show that the hRAD21 subunit of the cohesin compl... | |
medium_divergent_branch_03921 | BACE1 interacts with multiple members of the Golgi-localized, gamma-ear-containing, ARF-binding (GGA) protein family. One specific interaction is mediated by a DISLL sequence near the BACE C-terminus binding to the VHS domains of these proteins. Experimental evidence indicates that phosphorylation of a serine residue i... | ADP-ribosylation factor-binding protein GGA1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03921","source_qa_id":"medium_divergent_branch_03494","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"BACE1 interacts with multiple members of the Golgi-localized, gamma-ear-containing, ARF-binding (... | |
medium_divergent_branch_03924 | IL17A is associated with multiple biological processes. One association is supported by evidence stating: 'In response to IL-17 treatment, the mRNA expression of IL-1ß and IL-6 was significantly upregulated.' Identify the biological process linked to this specific association via the 'positively regulates' relationship... | interleukin-1 beta production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03924","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IL17A is associated with multiple biological processes. One association is supported by evidence stating: 'In response to IL-17 treatment, the mRNA e... | |
medium_divergent_branch_03925 | The gene RET interacts with multiple partners via binding. One such interaction is supported by evidence stating: 'In this study, we have demonstrated that the transducing adaptor molecule [binding partner] is recruited and activated by both the RET isoforms and by the rearranged cytoplasmatic RET/ptc2 oncoproteins as ... | plasma membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03925","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene RET interacts with multiple partners via binding. One such interaction is supported by evidence stating: 'In this study, we have demonstrate... | |
medium_divergent_branch_03927 | CD4 is involved in a specific developmental process where it and CD8 coreceptors are thought to play a crucial role. Which broader biological process is this specific process a subclass of? | immune system process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03927","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CD4 is involved in a specific developmental process where it and CD8 coreceptors are thought to play a crucial role. Which broader biological process... | |
medium_divergent_branch_03928 | Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.009 and an adjusted p-value of 0.034. For which disease is that selected gene recorded as a biomarker? | Ullrich congenital muscular dystrophy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03928","source_qa_id":"medium_divergent_branch_00374","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fo... | |
medium_divergent_branch_03929 | DDX42 is associated with multiple biological processes. One association is supported by evidence that ASPP2 localization shifts from the cytoplasm and nucleus to predominantly the cytoplasm as DDX42 concentration increases. Which biological process, connected to this specific DDX42-associated process via an 'is a' rela... | macromolecule localization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03929","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DDX42 is associated with multiple biological processes. One association is supported by evidence that ASPP2 localization shifts from the cytoplasm an... | |
medium_divergent_branch_03930 | MAFK interacts with multiple proteins. One interaction is supported by evidence stating: 'In vitro and in vivo analyses showed that a specific transcription factor can heterodimerize with MafK and that this complex binds to the MARE in the chicken beta-globin enhancer and can activate transcription.' Which protein is e... | Nuclear factor erythroid 2-related factor 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03930","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAFK interacts with multiple proteins. One interaction is supported by evidence stating: 'In vitro and in vivo analyses showed that a specific transc... | |
medium_divergent_branch_03931 | SLURP2 is associated with multiple biological processes. One association is supported by evidence that SLURP-2 inhibits acetylcholine-evoked currents at α4β2 and α3β2-nAChRs (IC50 ~0.17 and >3 μM, respectively) in Xenopus oocytes, while significantly enhancing currents at α7-nAChRs at concentrations <1 μM before induci... | regulation of signaling receptor activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03931","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SLURP2 is associated with multiple biological processes. One association is supported by evidence that SLURP-2 inhibits acetylcholine-evoked currents... | |
medium_divergent_branch_03932 | PLCG1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We also demonstrated the differentiation-dependent association of nuclear phosphorylated [protein] to phospholipase C-gamma1 and to the p85 regulatory subunit of phosphoinositide 3-kinase.' Which disease is associated with the pr... | melanoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03932","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PLCG1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We also demonstrated the differentiation-dependent associa... | |
medium_divergent_branch_03933 | SAP18 interacts with multiple genes. Evidence for one of these interactions identifies the partner as a polypeptide associated with the co-repressor protein Sin3. Which gene is connected to SAP18 through this specific interaction? | DNAJC7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03933","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SAP18 interacts with multiple genes. Evidence for one of these interactions identifies the partner as a polypeptide associated with the co-repressor ... | |
medium_divergent_branch_03934 | Pentosan polysulfate interacts with multiple drugs. Evidence indicates that Pentosan polysulfate (PPS) and Mucopolysaccharide (MPS) showed the strongest inhibition of the interaction between a specific interacting drug and the SARS-CoV-2 S-protein Receptor Binding Domain (RBD). Which disease is the drug exhibiting this... | pulmonary embolism | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03934","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Pentosan polysulfate interacts with multiple drugs. Evidence indicates that Pentosan polysulfate (PPS) and Mucopolysaccharide (MPS) showed the strong... | |
medium_divergent_branch_03935 | SAFB1 interacts with multiple proteins. One specific interaction is characterized by the following evidence: 'Mutation of the SAFB1 sumoylation sites lead to a loss of transcriptional repression, at least in part due to decreased interaction with this partner, a known transcriptional repressor and SAFB1 binding partner... | Histone deacetylase 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03935","source_qa_id":"medium_divergent_branch_01139","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"SAFB1 interacts with multiple proteins. One specific interaction is characterized by the followin... | |
medium_divergent_branch_03936 | The protein COMP is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by experimental evidence stating: 'Direct calcium binding experiments demonstrate that wild-type COMP, when purified in the presence of calcium, is a calcium-binding protein.' Based on ... | metal ion binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03936","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein COMP is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by experimenta... | |
medium_divergent_branch_03937 | Etidronic acid interacts with multiple substances. Evidence indicates that phosphonates block the algal assimilation of ions from one of these interacting substances through complexation. Which disease is the drug corresponding to that substance indicated for? | iron deficiency anemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03937","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Etidronic acid interacts with multiple substances. Evidence indicates that phosphonates block the algal assimilation of ions from one of these intera... | |
medium_divergent_branch_03938 | The microRNA mmu-miR-125b-5p regulates more than one cell type. One of these regulatory relationships is supported by evidence stating: 'Thus, we propose miR-125b-2 as a positive regulator of megakaryopoiesis and an oncomiR involved in the pathogenesis of trisomy 21-associated megakaryoblastic leukemia.' Identify the c... | megakaryocyte progenitor cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03938","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The microRNA mmu-miR-125b-5p regulates more than one cell type. One of these regulatory relationships is supported by evidence stating: 'Thus, we pro... | |
medium_divergent_branch_03939 | ABTB1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Immunoprecipitation and mass spectrometry revealed that a tripartite motif-containing protein interacts with ABTB1.' Which protein, connected to ABTB1 via this specific interaction, is the subject of the 'encodes' relation in the... | E3 ubiquitin-protein ligase TRIM4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03939","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ABTB1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Immunoprecipitation and mass spectrometry revealed that a ... | |
medium_divergent_branch_03940 | MDM2 interacts with multiple proteins. One specific interaction partner preferentially forms a stable complex with MDM2 even in the presence of excess p53. Which disease is associated with genomic alterations in this specific interaction partner? | intellectual disability | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03940","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MDM2 interacts with multiple proteins. One specific interaction partner preferentially forms a stable complex with MDM2 even in the presence of exces... | |
medium_divergent_branch_03941 | The gene EIF3G is associated with multiple partners via protein-protein interactions. One specific interaction is supported by experimental evidence stating that the partner protein interacts directly with eIF3c, eIF3g, and eIF3j, as demonstrated by glutathione S-transferase pull-down assays. Which protein corresponds ... | Eukaryotic translation initiation factor 3 subunit K | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03941","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene EIF3G is associated with multiple partners via protein-protein interactions. One specific interaction is supported by experimental evidence ... | |
medium_divergent_branch_03942 | CDKN1C interacts with multiple proteins. One of these interaction partners is reported to interact with p57Kip2 in vivo, as revealed by coimmunoprecipitation analysis. Which cellular component is this specific interaction partner located in? | SCF ubiquitin ligase complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03942","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDKN1C interacts with multiple proteins. One of these interaction partners is reported to interact with p57Kip2 in vivo, as revealed by coimmunopreci... | |
medium_divergent_branch_03944 | Ammon's horn is anatomically connected to a specific structure via a 'part of' relationship. Evidence for this connection describes a part of the brain consisting of a three-layered cortex located in the forebrain, bordering the medial surface of the lateral ventricle. The text notes that the term hippocampus is often ... | lobe of cerebral hemisphere | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03944","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Ammon's horn is anatomically connected to a specific structure via a 'part of' relationship. Evidence for this connection describes a part of the bra... | |
medium_divergent_branch_03947 | FLI1 interacts with multiple genes. One of these interacting partners is directly phosphorylated by a specific protein kinase C isoform, as demonstrated by several independent approaches. Which disease is associated with this specific interacting gene via a biomarker relationship? | cervical squamous cell carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03947","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FLI1 interacts with multiple genes. One of these interacting partners is directly phosphorylated by a specific protein kinase C isoform, as demonstra... | |
medium_divergent_branch_03949 | ATR interacts with multiple proteins. One of these interaction partners is characterized by a C-terminal domain containing a SOCS Box that mediates its interaction with DNA damage-regulated kinases, including ATR. Which protein, encoded by the gene connected to ATR via this specific interaction, is the subject of this ... | Suppressor of cytokine signaling 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03949","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATR interacts with multiple proteins. One of these interaction partners is characterized by a C-terminal domain containing a SOCS Box that mediates i... | |
medium_divergent_branch_03950 | SEPTIN9 interacts with multiple genes. One interaction is supported by evidence stating: 'We identify a consensus motif within the SEPT9 N-terminal domain that supports its association with the adaptor protein SH3KBP1.' Which disease is associated with this interaction partner? | immunodeficiency 61 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03950","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SEPTIN9 interacts with multiple genes. One interaction is supported by evidence stating: 'We identify a consensus motif within the SEPT9 N-terminal d... | |
medium_divergent_branch_03951 | DNMT1 interacts with multiple genes. One of these interaction partners is identified in a study where proteomic analysis of immunoprecipitates revealed association with the epigenetic machinery, specifically UHRF1, G9a, and the transcription factor Snail1. Which disease is associated with this specific interaction part... | acute myeloid leukemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03951","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DNMT1 interacts with multiple genes. One of these interaction partners is identified in a study where proteomic analysis of immunoprecipitates reveal... | |
medium_divergent_branch_03953 | KRT18 interacts with multiple genes. One specific interaction is supported by evidence stating: 'We have now identified human TNF receptor type 1 (TNFR1)-associated death domain protein to be the K18-interacting protein.' Which gene corresponds to this described interaction partner? | TNFRSF25 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03953","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KRT18 interacts with multiple genes. One specific interaction is supported by evidence stating: 'We have now identified human TNF receptor type 1 (TN... | |
medium_divergent_branch_03954 | The gene SLC4A1 encodes Anion exchanger 1 (AE1), which is described as the founding member of the solute carrier 4 (SLC4) family of bicarbonate transporters. This family includes chloride/bicarbonate anion exchangers and Na(+)-bicarbonate co-transporters. Based on this functional description, SLC4A1 enables a specific ... | transmembrane transporter activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03954","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene SLC4A1 encodes Anion exchanger 1 (AE1), which is described as the founding member of the solute carrier 4 (SLC4) family of bicarbonate trans... | |
medium_divergent_branch_03955 | GEMIN5 interacts with multiple proteins. One of these interaction partners is described as binding directly to SMN and functioning as a component of the SMN complex. Which protein, encoded by the gene corresponding to this specific interaction partner, is the target of the 'encodes' relationship? | Survival motor neuron protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03955","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GEMIN5 interacts with multiple proteins. One of these interaction partners is described as binding directly to SMN and functioning as a component of ... | |
medium_divergent_branch_03956 | The erythropoietin receptor (EPOR) interacts with multiple proteins. One specific interaction involves a Src family tyrosine kinase that physically associates with EPOR in Epo-dependent hematopoietic cell lines, such as 32D/EpoR-Wt and F36E. Which disease is associated with this specific interacting protein? | autoinflammatory disease, systemic, with vasculitis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03956","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The erythropoietin receptor (EPOR) interacts with multiple proteins. One specific interaction involves a Src family tyrosine kinase that physically a... | |
medium_divergent_branch_03958 | MARCH8 interacts with multiple proteins. One specific interaction is characterized by the mechanistic detail that MARCH8 targets the interacting protein's Lys512 residue for K48-linked polyubiquitination and subsequent degradation. Which protein, encoded by the gene connected to MARCH8 via this specific interaction, is... | Interleukin-1 receptor accessory protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03958","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MARCH8 interacts with multiple proteins. One specific interaction is characterized by the mechanistic detail that MARCH8 targets the interacting prot... | |
medium_divergent_branch_03959 | SCHIP1 interacts with multiple proteins. One interaction is supported by evidence stating: 'we have identified a novel coiled-coil protein, SCHIP-1, that specifically associates with schwannomin in vitro and in vivo.' Which protein is encoded by the gene that interacts with SCHIP1 in this specific context? | Merlin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03959","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SCHIP1 interacts with multiple proteins. One interaction is supported by evidence stating: 'we have identified a novel coiled-coil protein, SCHIP-1, ... | |
medium_divergent_branch_03960 | FLOT1 interacts with multiple proteins. One interaction is characterized by Flotillin-1 binding to the phosphotyrosine binding domain (PTB) of the partner protein and competing for binding with the fibroblast growth factor receptor. Which protein corresponds to this specific interaction partner? | Fibroblast growth factor receptor substrate 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03960","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FLOT1 interacts with multiple proteins. One interaction is characterized by Flotillin-1 binding to the phosphotyrosine binding domain (PTB) of the pa... | |
medium_divergent_branch_03961 | PPFIA1 interacts with multiple proteins. One interaction partner is supported by evidence stating that a specific receptor-type tyrosine-protein phosphatase, HPTP delta, and HPTP sigma exhibit similar in vitro PTPase activities and all three interact with LIP.1, which has been postulated to recruit this specific recept... | Receptor-type tyrosine-protein phosphatase F | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03961","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PPFIA1 interacts with multiple proteins. One interaction partner is supported by evidence stating that a specific receptor-type tyrosine-protein phos... | |
medium_divergent_branch_03962 | LDLRAP1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that ARH also binds to the first FXNPXY motif of megalin in two-hybrid, pull-down and coimmunoprecipitation assays.' Which protein, connected to LDLRAP1 via this specific evidence, is encoded by the gene in question? | Low-density lipoprotein receptor-related protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03962","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LDLRAP1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that ARH also binds to the first FXNPXY motif o... | |
medium_divergent_branch_03963 | The gene EXO1 is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'We demonstrate that hMSH2 interacts with a human 5'-3' exonuclease 1 (hEXO1/HEX1) and that this interaction is mediated through their C-terminal domains.' Based on this evidence, which protein is the i... | DNA mismatch repair protein Msh2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03963","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene EXO1 is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'We demonstrate that hMSH2 inte... | |
medium_divergent_branch_03964 | PAWR interacts with multiple proteins. One interaction partner is described as a novel nuclear proapoptotic factor associated with PML nuclear bodies (NBs), which potentiates both serum withdrawal- and TNF alpha-induced apoptosis and interacts with prostate-apoptosis-response-4 (Par-4). Which protein, connected to PAWR... | THAP domain-containing protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03964","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PAWR interacts with multiple proteins. One interaction partner is described as a novel nuclear proapoptotic factor associated with PML nuclear bodies... | |
medium_divergent_branch_03965 | Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.027 and an adjusted p-value of 0.0484. In which cell is that selected gene enriched? | mucosal-associated invariant T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03965","source_qa_id":"medium_divergent_branch_00878","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showe... | |
medium_divergent_branch_03967 | The gene SLC22A16 is associated with multiple molecular functions. One specific function is supported by experimental evidence showing that Xenopus oocytes injected with SLC22A16 cRNA import doxorubicin, a widely used anticancer drug for hematological malignancies, in a saturable and dose-dependent manner. Which biolog... | amine transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03967","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene SLC22A16 is associated with multiple molecular functions. One specific function is supported by experimental evidence showing that Xenopus o... |
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