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medium_divergent_branch_03968 | SEPT4 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating: 'Here, we show the physiological association of SEPT4 with alpha-synuclein, the dopamine transporter, and other presynaptic proteins in dopaminergic neurons; mice lacking S... | synapse | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03968","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SEPT4 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating: '... | |
medium_divergent_branch_03969 | The gene BCO2 is associated with multiple biological processes. One association is supported by evidence stating: 'Mammalian cells thus express a mitochondrial carotenoid-oxygenase that degrades carotenoids to protect these vital organelles.' Identify the biological process linked to this specific function via an 'is a... | terpenoid metabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03969","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene BCO2 is associated with multiple biological processes. One association is supported by evidence stating: 'Mammalian cells thus express a mit... | |
medium_divergent_branch_03970 | GPX4 interacts with multiple proteins. One interaction is supported by evidence stating: 'Mechanistically, DLPC downregulated the deubiquitinase [interaction partner], which normally stabilizes glutathione peroxidase 4 through TRAF/CAT domain-mediated binding and deubiquitination activity.' Which protein is encoded by ... | Ubiquitin carboxyl-terminal hydrolase 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03970","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GPX4 interacts with multiple proteins. One interaction is supported by evidence stating: 'Mechanistically, DLPC downregulated the deubiquitinase [int... | |
medium_divergent_branch_03971 | NFKB1 interacts with multiple proteins. One of these interaction partners is described as interacting directly with RelA, p50, and several subunits of the SWI/SNF complex in vitro, and is co-immunoprecipitated with RelA/p50 and the SWI/SNF complex from the nuclear fractions of cells treated with TNF-α. Which protein is... | Zinc finger protein DPF3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03971","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NFKB1 interacts with multiple proteins. One of these interaction partners is described as interacting directly with RelA, p50, and several subunits o... | |
medium_divergent_branch_03973 | RALGDS interacts with multiple genes. One interaction is supported by evidence stating: 'When co-transfected in HeLa cells, an activated mutant of a specific Ras-related protein (Val-12 mutant) but not an inactive protein (Ala-35 mutant) co-immunoprecipitates with RalGDS and Rlf.' Which protein is encoded by the gene t... | Ras-related protein Rap-2a | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03973","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RALGDS interacts with multiple genes. One interaction is supported by evidence stating: 'When co-transfected in HeLa cells, an activated mutant of a ... | |
medium_divergent_branch_03974 | YOD1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In the current study, we found that YOD1 directly interacts with α-synuclein and deubiquitinates K6-, K11-, K29-, K33-, and K63-linked polyubiquitin chains on α-synuclein.' Which protein, encoded by the gene connected to YOD1 via ... | Alpha-synuclein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03974","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"YOD1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In the current study, we found that YOD1 directly interacts... | |
medium_divergent_branch_03975 | TOM1L1 interacts with multiple proteins. One interaction is supported by evidence stating that the C-terminal regions of all Tom1 family proteins interact with clathrin. Which protein, connected to TOM1L1 via this interaction, is encoded by the gene in question? | Clathrin heavy chain 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03975","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TOM1L1 interacts with multiple proteins. One interaction is supported by evidence stating that the C-terminal regions of all Tom1 family proteins int... | |
medium_divergent_branch_03976 | SMAD7 interacts with multiple proteins. One interaction partner is characterized by evidence stating that the C-terminal MH2 region, but not the MH1 region, of SMAD7 is critical for its interaction with this partner to inhibit the ubiquitination of EGFR. Which protein is encoded by the gene corresponding to this specif... | E3 ubiquitin-protein ligase CBL | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03976","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMAD7 interacts with multiple proteins. One interaction partner is characterized by evidence stating that the C-terminal MH2 region, but not the MH1 ... | |
medium_divergent_branch_03977 | ATM interacts with multiple genes. One interaction is supported by evidence stating: 'Here we show that a telomere-binding protein coimmunoprecipitated with ATM, and its phosphorylation was increased in an ATM-dependent manner by ionizing DNA damage.' Which disease is causally linked to the gene identified by this spec... | gastric adenocarcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03977","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATM interacts with multiple genes. One interaction is supported by evidence stating: 'Here we show that a telomere-binding protein coimmunoprecipitat... | |
medium_divergent_branch_03979 | C9orf72 interacts with multiple proteins. One interaction is supported by evidence stating: 'Mass spectrometry and biochemical analyses reveal the E3 ligase [protein] and the BAG6 chaperone complex as C9orf72-interacting proteins, which are components of the machinery that modifies proteins with K11/K48-linked heteroty... | E3 ubiquitin-protein ligase UBR5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03979","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"C9orf72 interacts with multiple proteins. One interaction is supported by evidence stating: 'Mass spectrometry and biochemical analyses reveal the E3... | |
medium_divergent_branch_03980 | MYLIP interacts with multiple proteins. One interaction is supported by evidence citing NMR chemical shift mapping and a 2.1 Å crystal structure of the IDOL RING domain complexed with a specific E2 enzyme, which revealed key interactions between the dimeric IDOL protein and this partner. What is the name of the protein... | Ubiquitin-conjugating enzyme E2 D1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03980","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MYLIP interacts with multiple proteins. One interaction is supported by evidence citing NMR chemical shift mapping and a 2.1 Å crystal structure of t... | |
medium_divergent_branch_03981 | KCNQ1 interacts with multiple proteins. One of these interactions is supported by evidence stating that 'Coimmunoprecipitation assays suggested that the interaction partner can bind to KCNQ1 independently of the PY motif.' What is the protein name encoded by this interaction partner? | Ubiquitin carboxyl-terminal hydrolase 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03981","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KCNQ1 interacts with multiple proteins. One of these interactions is supported by evidence stating that 'Coimmunoprecipitation assays suggested that ... | |
medium_divergent_branch_03982 | Peristalsis is associated with multiple anatomical structures. One such structure is described as one of two ganglionated neural networks that together form the enteric nervous system. Specifically, the myenteric (Auerbach's) plexus is located between the longitudinal and circular muscle layers of the gut. Its neurons ... | muscle layer of intestine | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03982","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Peristalsis is associated with multiple anatomical structures. One such structure is described as one of two ganglionated neural networks that togeth... | |
medium_divergent_branch_03983 | TRAF2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Co-immunoprecipitation showed that TRAF2 could interact with this partner in MCF-10A, MCF-7 and MDA-MB-231 cell lines.' Which gene is connected to this interaction partner through a subsequent interaction? | ARNT2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03983","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRAF2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Co-immunoprecipitation showed that TRAF2 could inter... | |
medium_divergent_branch_03984 | TNFSF14 interacts with multiple proteins. One interaction partner is described as binding two types of tumor necrosis factor family cytokines, specifically the heterotrimer LT alpha 1 beta 2 and the homotrimer LIGHT, and activating signaling pathways including NF-kappa B, c-Jun N-terminal kinase, and cell death. Which ... | Tumor necrosis factor receptor superfamily member 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03984","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TNFSF14 interacts with multiple proteins. One interaction partner is described as binding two types of tumor necrosis factor family cytokines, specif... | |
medium_divergent_branch_03985 | ABCE1 is associated with multiple biological processes. One of these processes is supported by evidence that ABCE1, along with Pelota and Hbs1, dissociates vacant 80S ribosomes to stimulate 48S complex formation, indicating a role beyond No-Go Decay (NGD). Which broader biological category, defined by an 'is a' relatio... | organelle disassembly | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03985","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ABCE1 is associated with multiple biological processes. One of these processes is supported by evidence that ABCE1, along with Pelota and Hbs1, disso... | |
medium_divergent_branch_03986 | CTNNA1 interacts with multiple genes. One interaction is supported by evidence stating: 'We therefore propose that cadherin/catenin complexes are linked to the actin cytoskeleton via a direct association between alpha-actinin and alpha-catenin.' Which disease is connected to the gene identified by this evidence through... | autosomal dominant macrothrombocytopenia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03986","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CTNNA1 interacts with multiple genes. One interaction is supported by evidence stating: 'We therefore propose that cadherin/catenin complexes are lin... | |
medium_divergent_branch_03987 | BARD1 interacts with multiple proteins. One of these interaction partners is characterized by its ability to bind Lys9-dimethylated histone H3 (H3K9me2) in an ATM-dependent but RNF168-independent manner following DNA damage. Which gene encodes this specific interaction partner? | Histone H3.1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03987","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BARD1 interacts with multiple proteins. One of these interaction partners is characterized by its ability to bind Lys9-dimethylated histone H3 (H3K9m... | |
medium_divergent_branch_03988 | CHEK1 interacts with multiple proteins. One of these interaction partners is a protein that localizes to the nucleus but only associates with Chk1 following replication stress or other types of DNA damage. Which disease is associated with this specific interaction partner? | telangiectasis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03988","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CHEK1 interacts with multiple proteins. One of these interaction partners is a protein that localizes to the nucleus but only associates with Chk1 fo... | |
medium_divergent_branch_03989 | The gene KPNA1 interacts with multiple partners. One specific interaction is supported by evidence stating: 'Binding affinity studies showed that all importin alpha proteins from humans or Xenopus bind their import receptor (importin beta) and their export receptor (CAS) with only marginal differences.' Which protein i... | Importin subunit beta-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03989","source_qa_id":"medium_divergent_branch_01193","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene KPNA1 interacts with multiple partners. One specific interaction is supported by evidenc... | |
medium_divergent_branch_03990 | RNF216 interacts with multiple genes. One interaction partner physically associates with Triad3A, and residues Y440 and Q442 of this partner—previously established as critical for binding the MAVS adapter—are also essential for its interaction with Triad3A. Which disease is linked to this specific interaction partner v... | breast cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03990","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF216 interacts with multiple genes. One interaction partner physically associates with Triad3A, and residues Y440 and Q442 of this partner—previous... | |
medium_divergent_branch_03991 | The angular vein is a type of anatomy. Evidence for one of its classifications describes an entity formed by the junction of the frontal vein and supraorbital vein, which runs obliquely downward on the side of the root of the nose to the level of the lower margin of the orbit, where it becomes the anterior facial vein.... | blood vessel | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03991","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The angular vein is a type of anatomy. Evidence for one of its classifications describes an entity formed by the junction of the frontal vein and sup... | |
medium_divergent_branch_03992 | SMAD4 interacts with multiple proteins. One interaction partner is characterized by evidence stating that TIF1γ's ability to ubiquitinate its substrate requires its PHD finger-bromodomain, as does its transcriptional repressor activity. Which cellular component is the gene encoding this specific interaction partner loc... | nucleus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03992","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMAD4 interacts with multiple proteins. One interaction partner is characterized by evidence stating that TIF1γ's ability to ubiquitinate its substra... | |
medium_divergent_branch_03993 | The gene HES1 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 22.19 TPM, a z-score of 2.02, and a fold enrichment of 5.13. Which cell type corresponds to this specific expression profile, and what is its immediate parent class in the cell ontology... | monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03993","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene HES1 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 22.19 TPM, a z... | |
medium_divergent_branch_03994 | OTUD3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we report OTUD3 (OTU domain-containing protein 3) functions as a deubiquitylase for the protein encoded by IREB2, interacts with the protein encoded by IREB2 in the cytoplasm, de-polyubiquitylates, and stabilizes the protei... | Iron-responsive element-binding protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03994","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"OTUD3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we report OTUD3 (OTU domain-containing protein 3) fu... | |
medium_divergent_branch_03995 | PAX8 is involved in multiple biological processes. One of these processes is supported by evidence showing PAX8 expression in the developing central nervous system and kidney, specifically including the ureteric bud and the main collecting ducts. Which biological process is a part of the process connected to PAX8 via t... | renal system development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03995","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PAX8 is involved in multiple biological processes. One of these processes is supported by evidence showing PAX8 expression in the developing central ... | |
medium_divergent_branch_03996 | The gene PBK is known to interact with several proteins. One specific interaction is supported by evidence stating: 'Using this approach we identify and confirm six novel [protein] binding partners: KCNA4, PAK6, PLEKHG5, PKC-alpha1, TYK2 and PBK, and suggest that [protein] functions as a signalling scaffold.' Which pro... | E3 ubiquitin-protein ligase LNX | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03996","source_qa_id":"medium_divergent_branch_05458","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene PBK is known to interact with several proteins. One specific interaction is supported by... | |
medium_divergent_branch_03997 | The IgM immunoglobulin complex is associated with multiple cell types via the plasma membrane. One such cell is a mature B cell subset originally defined by the phenotype CD45R-positive, IgM-positive, IgD-positive, and CD43-negative. Subsequent research characterized this subset as CD21-positive, CD23-negative, and CD9... | B-2 B cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03997","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The IgM immunoglobulin complex is associated with multiple cell types via the plasma membrane. One such cell is a mature B cell subset originally def... | |
medium_divergent_branch_03998 | TPCN1 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by the evidence: 'Thus, TPC1 is a member of a new family of voltage-gated Na(+) channels that senses pH changes and confers electrical excitability to organelles.' Identify the parent molecular fu... | sodium channel activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03998","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TPCN1 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by the evidence: 'Thus, T... | |
medium_divergent_branch_03999 | LAPTM5 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating: 'The Nedd4-LAPTM5 complex recruits ubiquitinated GGA3, which binds the LAPTM5-UIM.' Based on this mechanistic description involving a multi-protein assembly, which of the ... | cellular_component | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_03999","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LAPTM5 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating: ... | |
medium_divergent_branch_04000 | AGO1 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we show that the N-terminal GW-repeat-containing regions of all three TNRC6s interact with the four human Argonaute proteins (AGO1-AGO4).' Which protein is encoded by the gene connected to AGO1 through this specific interaction... | Trinucleotide repeat-containing gene 6A protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04000","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AGO1 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we show that the N-terminal GW-repeat-containing regions... | |
medium_divergent_branch_04001 | PGAM1 interacts with multiple genes. One of these interacting partners has been shown to enhance the protein stability of phosphoglycerate mutase 1 (PGAM1) via direct interaction. Which disease is associated with this specific interacting partner through a biomarker relationship? | major depressive disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04001","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PGAM1 interacts with multiple genes. One of these interacting partners has been shown to enhance the protein stability of phosphoglycerate mutase 1 (... | |
medium_divergent_branch_04002 | MALT1 interacts with multiple proteins. One of these interaction partners is described in a study stating: 'Mechanistically, we demonstrate that this protein physically interacts with paracaspase MALT1 and activates MALT1 proteolytic activity and inflammatory gene expression, which are enhanced by psoriasis-associated ... | Caspase recruitment domain-containing protein 14 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04002","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MALT1 interacts with multiple proteins. One of these interaction partners is described in a study stating: 'Mechanistically, we demonstrate that this... | |
medium_divergent_branch_04003 | GABARAP interacts with multiple genes. One of these interacting partners is characterized by the following evidence: 'Binding of a specific protein to this partner is indispensable for its recruitment to LC3B-positive structures and, thus, for the clearance of certain p62 structures by autophagy.' Which disease is asso... | microcephaly 18, primary, autosomal dominant | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04003","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GABARAP interacts with multiple genes. One of these interacting partners is characterized by the following evidence: 'Binding of a specific protein t... | |
medium_divergent_branch_04005 | CD36 is associated with multiple biological processes. One association is supported by evidence stating: 'Our results identify CD36-TLR4-TLR6 activation as a common molecular mechanism by which atherogenic lipids and amyloid-beta stimulate sterile inflammation and suggest a new model of TLR heterodimerization triggered... | defense response | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04005","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CD36 is associated with multiple biological processes. One association is supported by evidence stating: 'Our results identify CD36-TLR4-TLR6 activat... | |
medium_divergent_branch_04006 | EIF4A1 interacts with multiple genes. One of these interaction partners is a protein that suppresses the translation of mRNAs containing structured 5' UTRs by binding to eukaryotic translation initiation factor 4A (eIF4A) and inhibiting its helicase activity. This specific partner has also been reported to physically i... | adenoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04006","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EIF4A1 interacts with multiple genes. One of these interaction partners is a protein that suppresses the translation of mRNAs containing structured 5... | |
medium_divergent_branch_04007 | IRS1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Interestingly, when C57MG cells were treated with insulin, only p55PIK, but not p50PIK, bound to insulin receptor substrate-1 protein, providing evidence that different forms of p55PIKs may have specific distinct roles in s... | eosinophil | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04007","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IRS1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Interestingly, when C57MG cells were treated with in... | |
medium_divergent_branch_04009 | KCNMA1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The interaction between a membrane-associated guanylate kinase protein and BK(Ca) channels was confirmed by coimmunoprecipitation and glutathione S-transferase pull-down assays in differentiated cells of a podocyte cell... | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04009","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KCNMA1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The interaction between a membrane-associated gu... | |
medium_divergent_branch_04010 | The gene COL1A1 interacts with multiple other genes. One of these interacting partners is supported by evidence stating that 'CP-pro alpha 1(1) stably binds to wild type [the interacting partner's protein] but not to mutant [the interacting partner's protein], in which redox-active cysteine residues are substituted.' W... | Thioredoxin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04010","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene COL1A1 interacts with multiple other genes. One of these interacting partners is supported by evidence stating that 'CP-pro alpha 1(1) stabl... | |
medium_divergent_branch_04011 | The gene AGTR1 interacts with multiple other genes. One of these interacting partners is described in the literature as an 'AT(1A)R-binding protein that selectively associates with the AT(1A)R and not with the beta2-adrenergic receptor.' Which protein is encoded by the gene that interacts with AGTR1 and matches this de... | Ras-related protein Rab-5A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04011","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene AGTR1 interacts with multiple other genes. One of these interacting partners is described in the literature as an 'AT(1A)R-binding protein t... | |
medium_divergent_branch_04013 | GRHL2 is associated with multiple biological processes. One association is supported by evidence that immortalized keratinocytes with the p.Ile482Lys mutation exhibited altered cell morphology, impaired tight junctions, adhesion defects, and cytoplasmic translocation of GRHL2. Which biological process, connected to the... | tight junction assembly | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04013","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GRHL2 is associated with multiple biological processes. One association is supported by evidence that immortalized keratinocytes with the p.Ile482Lys... | |
medium_divergent_branch_04014 | MARK3 interacts with multiple proteins. One of these interaction partners has been shown to physically interact with C-TAK1 upon transient overexpression in COS-7 cells. Which protein is encoded by the gene corresponding to this interaction partner? | M-phase inducer phosphatase 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04014","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MARK3 interacts with multiple proteins. One of these interaction partners has been shown to physically interact with C-TAK1 upon transient overexpres... | |
medium_divergent_branch_04015 | The gene RRAS is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 20.53 TPM, a z-score of 2.57, and a fold enrichment of 10.63. Identify the cell type that is the developmental precursor to the cell type associated with these specific expression statistics. | intermediate monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04015","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene RRAS is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 20.53 TPM, a z-score of 2... | |
medium_divergent_branch_04016 | The protein ACTB is involved in multiple biological processes. One specific connection is supported by evidence stating: 'This is the first direct demonstration of NET activity being regulated via actin and modulated by interactions with alpha-Syn.' Identify the biological process that is connected to this specific ACT... | norepinephrine uptake | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04016","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein ACTB is involved in multiple biological processes. One specific connection is supported by evidence stating: 'This is the first direct de... | |
medium_divergent_branch_04017 | MEF2C is involved in multiple biological processes. One such process is supported by evidence that skMLCK regulates MRF expression by controlling the MEF2C-dependent recruitment of histone acetyltransferases to skeletal muscle promoters. Which biological process, connected to MEF2C via 'involved in', is the subject of ... | gene expression | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04017","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MEF2C is involved in multiple biological processes. One such process is supported by evidence that skMLCK regulates MRF expression by controlling the... | |
medium_divergent_branch_04018 | AP2A1 interacts with multiple genes. One interaction is supported by evidence stating: 'Through affinity purification followed by mass spectrum analysis, we identified adaptor protein (AP) 2 together with phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) as binding proteins of microtubule-associ... | hyperphosphatemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04018","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AP2A1 interacts with multiple genes. One interaction is supported by evidence stating: 'Through affinity purification followed by mass spectrum analy... | |
medium_divergent_branch_04019 | RUNX2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We show that signal transducers of transforming growth factor beta superfamily receptors, Smads, interact with this protein in vivo and in vitro and enhance the transactivation ability of this factor.' Which disease is a... | aneurysm-osteoarthritis syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04019","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RUNX2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We show that signal transducers of transforming g... | |
medium_divergent_branch_04020 | DAB2IP is associated with multiple biological processes. One association is supported by evidence stating: 'Here, we show that DAB2IP protein, often down-regulated in PCa, is a potent growth inhibitor by inducing G(0)/G(1) cell cycle arrest and is proapoptotic in response to stress.' Which biological process, connected... | regulation of cellular process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04020","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DAB2IP is associated with multiple biological processes. One association is supported by evidence stating: 'Here, we show that DAB2IP protein, often ... | |
medium_divergent_branch_04021 | SIRT2 interacts with multiple proteins. One specific interaction partner is deacetylated by SIRT2 at lysine 32 (K32) in response to replication stress. Which disease is associated with this specific interaction partner through genomic alterations? | Seckel syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04021","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SIRT2 interacts with multiple proteins. One specific interaction partner is deacetylated by SIRT2 at lysine 32 (K32) in response to replication stres... | |
medium_divergent_branch_04022 | The protein NOS1AP is associated with multiple biological processes. One association is supported by evidence stating: 'We find that CAPON protein is expressed in the heart and interacts with NOS1 to accelerate cardiac repolarization by inhibition of L-type calcium channel.' Identify the biological process that is conn... | ventricular cardiac muscle cell membrane repolarization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04022","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein NOS1AP is associated with multiple biological processes. One association is supported by evidence stating: 'We find that CAPON protein is... | |
medium_divergent_branch_04023 | KIF26A is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence stating: 'Combining mice and human iPSC-derived organoid models, we discovered that loss of KIF26A causes excitatory neuron-specific defects in radial migration, localization, de... | neuron migration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04023","source_qa_id":"medium_divergent_branch_04475","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"KIF26A is associated with multiple biological processes via the 'involved in' relationship. One s... | |
medium_divergent_branch_04024 | Basophil differentiation is enabled by more than one cell type. One such cell is a progenitor committed to the basophil lineage that is lin-negative, CD34-positive, T1/ST2-low, CD117-negative, and FceRIa-high, and expresses Gata-1, Gata-2, and C/EBPa. Which cell does this specific progenitor develop from? | basophil mast progenitor cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04024","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Basophil differentiation is enabled by more than one cell type. One such cell is a progenitor committed to the basophil lineage that is lin-negative,... | |
medium_divergent_branch_04025 | BRD8 interacts with multiple proteins. One specific interaction was identified through Yeast two-hybrid screening and subsequent immunoprecipitation analysis, which confirmed BRD8 as an interacting partner for a specific protein. Which disease is associated with this specific interacting protein? | carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04025","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BRD8 interacts with multiple proteins. One specific interaction was identified through Yeast two-hybrid screening and subsequent immunoprecipitation ... | |
medium_divergent_branch_04026 | TRPM2 is associated with multiple biological processes. One specific association is supported by evidence describing TRPM2 as a tetrameric Ca(2+)-permeable channel involved in immunocyte respiratory burst and postischaemic neuronal death. Identify the biological process linked to this specific association via an 'is a'... | calcium ion transmembrane transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04026","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRPM2 is associated with multiple biological processes. One specific association is supported by evidence describing TRPM2 as a tetrameric Ca(2+)-per... | |
medium_divergent_branch_04027 | AHSA1 interacts with multiple proteins. One of these interaction partners is characterized by experimental evidence showing that Hsp70 and Hsp90 associate equally with its wild-type and DeltaF508 mutant forms, whereas nearly twice as much of the Hsp90 cochaperone Aha1 associates with the DeltaF508 mutant. Which protein... | Cystic fibrosis transmembrane conductance regulator | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04027","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AHSA1 interacts with multiple proteins. One of these interaction partners is characterized by experimental evidence showing that Hsp70 and Hsp90 asso... | |
medium_divergent_branch_04028 | MYO5B interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Yeast two hybrid assays showed that amino acids 129-356 of the interacting partner protein were important for binding to myosin Vb tail.' Which protein is encoded by the gene corresponding to this interacting partner? | Rab11 family-interacting protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04028","source_qa_id":"medium_divergent_branch_01419","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"MYO5B interacts with multiple proteins. One specific interaction is supported by evidence stating... | |
medium_divergent_branch_04029 | ZDHHC17 interacts with multiple proteins. One of these interaction partners is identified in a study using LuTHy affinity capture, which reported interactions for the presynaptic chaperone CSPα (associated with adult-onset neuronal ceroid lipofuscinosis). Which protein, encoded by the gene interacting with ZDHHC17 in t... | DnaJ homolog subfamily C member 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04029","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZDHHC17 interacts with multiple proteins. One of these interaction partners is identified in a study using LuTHy affinity capture, which reported int... | |
medium_divergent_branch_04030 | Interleukin-21 (IL21) is involved in multiple biological processes. One specific process is supported by evidence that IL-21 increases the cytotoxicity of natural killer (NK) cells against K562 target cells. Which biological process is positively regulated by this IL21-associated process? | natural killer cell mediated cytotoxicity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04030","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Interleukin-21 (IL21) is involved in multiple biological processes. One specific process is supported by evidence that IL-21 increases the cytotoxici... | |
medium_divergent_branch_04031 | The gene DAB1 interacts with multiple partners. One specific interaction is characterized by the requirement that signaling through certain receptors depends on the binding of their cytoplasmic tails to the intracellular adaptor protein Disabled-1 (DAB1). Which disease is associated with the gene that engages in this s... | myocardial infarction, susceptibility to | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04031","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene DAB1 interacts with multiple partners. One specific interaction is characterized by the requirement that signaling through certain receptors... | |
medium_divergent_branch_04033 | TBX5 is associated with multiple biological processes. One of these processes is supported by evidence stating that the TBX5 transcription factor is expressed not only in the myocardium, but also throughout the embryonic epicardium and coronary vasculature. Which biological process is a part of the process identified b... | circulatory system development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04033","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TBX5 is associated with multiple biological processes. One of these processes is supported by evidence stating that the TBX5 transcription factor is ... | |
medium_divergent_branch_04034 | RPGR interacts with multiple genes. One interaction is supported by mass spectrometric analysis of proteins immunoprecipitated from a retinal axoneme-enriched fraction using an anti-ORF15 antibody, which identified two chromosome-associated proteins: structural maintenance of chromosomes (SMC) 1 and another SMC protein... | Roberts-SC phocomelia syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04034","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RPGR interacts with multiple genes. One interaction is supported by mass spectrometric analysis of proteins immunoprecipitated from a retinal axoneme... | |
medium_divergent_branch_04035 | Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.865 and an adjusted p-value of 0.0459. Which disease is associated with that selected gene? | developmental and epileptic encephalopathy, 88 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04035","source_qa_id":"medium_divergent_branch_01190","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch sho... | |
medium_divergent_branch_04036 | ARF1 interacts with multiple proteins. One specific interaction is described by the evidence: 'In addition, we demonstrate a direct interaction of the epsilon and mu4 subunits of AP-4 with ARF1.' Which protein, encoded by the gene corresponding to the mu4 subunit of AP-4, is the target of this interaction? | AP-4 complex subunit mu-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04036","source_qa_id":"medium_divergent_branch_01520","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ARF1 interacts with multiple proteins. One specific interaction is described by the evidence: 'In... | |
medium_divergent_branch_04037 | PRKCD interacts with multiple proteins. One interaction is supported by evidence stating: 'This study demonstrates that protein kinase C delta (PKCdelta) associates with SHPTP1.' Which protein, encoded by the gene connected to PRKCD via this specific interaction, is the subject of this evidence? | Tyrosine-protein phosphatase non-receptor type 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04037","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRKCD interacts with multiple proteins. One interaction is supported by evidence stating: 'This study demonstrates that protein kinase C delta (PKCde... | |
medium_divergent_branch_04038 | CPEB3 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating that CPEB3 is a nucleocytoplasm-shuttling RNA-binding protein that predominantly resides in this component, where it represses target RNA translation. Which cellular compone... | intracellular anatomical structure | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04038","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CPEB3 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating th... | |
medium_divergent_branch_04039 | The gene DNM2 is enriched in multiple cell types. One specific cell type shows a mean expression of 20.42 TPM, a z-score of 2.08, and a fold enrichment of 2.78. Which cell type corresponds to these expression statistics, and what is its immediate parent category in the cell type hierarchy (i.e., what is it a type of)? | group 1 innate lymphoid cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04039","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene DNM2 is enriched in multiple cell types. One specific cell type shows a mean expression of 20.42 TPM, a z-score of 2.08, and a fold enrichme... | |
medium_divergent_branch_04040 | Human orthopneumovirus downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.118 and an adjusted p-value of 0.0412. Which protein does that selected gene encode? | Sulfhydryl oxidase 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04040","source_qa_id":"medium_divergent_branch_05398","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human orthopneumovirus downregulates several genes. In the recorded experiment, one branch sho... | |
medium_divergent_branch_04041 | MARK4 is involved in a biological process that acts as a critical positive regulator of early steps in ciliogenesis. What is the specific biological process that is positively regulated by this regulatory process? | cilium assembly | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04041","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MARK4 is involved in a biological process that acts as a critical positive regulator of early steps in ciliogenesis. What is the specific biological ... | |
medium_divergent_branch_04042 | The NBN gene is known to interact with multiple protein partners. One specific interaction involves a protein that physically interacts with NBS1 and is required for the optimal recruitment of NBS1 and DNA polymerase eta (Polη) to UV-induced damage sites. Which protein is encoded by the gene corresponding to this inter... | E3 ubiquitin-protein ligase parkin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04042","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The NBN gene is known to interact with multiple protein partners. One specific interaction involves a protein that physically interacts with NBS1 and... | |
medium_divergent_branch_04043 | DERL1 interacts with multiple proteins. One interaction involves a partner that, along with a specific E3 ubiquitin ligase, promotes the proteasomal degradation of CFTR by retaining it in the ER membrane. Which protein is encoded by the gene corresponding to this specific interaction partner? | E3 ubiquitin-protein ligase RNF5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04043","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DERL1 interacts with multiple proteins. One interaction involves a partner that, along with a specific E3 ubiquitin ligase, promotes the proteasomal ... | |
medium_divergent_branch_04044 | CIITA interacts with multiple proteins. One interaction is characterized by evidence stating: 'Site-directed alanine mutagenesis of these residues together with in vitro and in vivo binding studies elucidated how RFXAP and CIITA, which simultaneously interact with this protein in vivo, bind to two opposite faces of its... | DNA-binding protein RFXANK | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04044","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CIITA interacts with multiple proteins. One interaction is characterized by evidence stating: 'Site-directed alanine mutagenesis of these residues to... | |
medium_divergent_branch_04045 | ING1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here, we report that ING1b interacts with karyopherins alpha2 and beta1 through several basic nuclear localization sequences (NLS) located adjacent to the ING1b PHD region.' Which disease is connected to the gene encoding ka... | astrocytoma (excluding glioblastoma) | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04045","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ING1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here, we report that ING1b interacts with karyopherin... | |
medium_divergent_branch_04046 | Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.956 and an adjusted p-value of 0.00112. Which protein does that selected gene encode? | Histone H4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04046","source_qa_id":"medium_divergent_branch_03216","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fo... | |
medium_divergent_branch_04047 | PBRM1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We demonstrate that bromodomain 2 of PB preferentially recognizes acetylated lysine 14 of histone H3 (H3K14ac), a post-translational mark known for gene transcriptional activation.' Which protein is encoded by the gene correspond... | Histone H3.1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04047","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PBRM1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We demonstrate that bromodomain 2 of PB preferentially rec... | |
medium_divergent_branch_04048 | GGA1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We report that the Vps10p domain receptor sorLA binds the adaptor proteins GGA1 and -2, which take part in Golgi-endosome sorting.' Which protein, connected to GGA1 via an interaction, is encoded by the gene identified in this con... | Sortilin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04048","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GGA1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We report that the Vps10p domain receptor sorLA binds the a... | |
medium_divergent_branch_04049 | E2F4 interacts with multiple proteins. One interaction is supported by evidence stating: 'We provide evidence that the cell cycle arrest program activated by TGF-beta in human keratinocytes includes the generation of E2F4-p130 complexes that in association with histone deacetylase HDAC1 inhibit the activity of the cdc2... | Retinoblastoma-like protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04049","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"E2F4 interacts with multiple proteins. One interaction is supported by evidence stating: 'We provide evidence that the cell cycle arrest program acti... | |
medium_divergent_branch_04050 | LRP1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Metabolic labeling and ligand binding analyses showed that both tPA and LRP are synthesized by hippocampal neurons and that LRP is the major cell surface receptor that binds tPA.' Which protein, encoded by the gene involv... | Tissue-type plasminogen activator | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04050","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LRP1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Metabolic labeling and ligand binding analyses sho... | |
medium_divergent_branch_04051 | West Nile virus upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.424 and an adjusted p-value of 0.00793. Which protein does that selected gene encode? | Interferon-induced protein 44 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04051","source_qa_id":"medium_divergent_branch_04934","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"West Nile virus upregulates several genes. In the recorded experiment, one branch showed a log... | |
medium_divergent_branch_04053 | ALK interacts with multiple proteins. One interaction partner is implicated in a study where treatment with 17-AAG decreased NPM-ALK expression and phosphorylation, thereby impairing its association with phospholipase C-gamma, Src homology 2 domain-containing protein (Shc), growth factor receptor-bound protein 2 (Grb2)... | bipolar disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04053","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ALK interacts with multiple proteins. One interaction partner is implicated in a study where treatment with 17-AAG decreased NPM-ALK expression and p... | |
medium_divergent_branch_04054 | RTCB interacts with multiple genes. One of these interaction partners is identified in the literature as a deubiquitinase that acts as a central coordinator, interacting and co-localizing with both RTCB and DDX1. Which disease is associated with this specific gene? | Leber congenital amaurosis 19 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04054","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RTCB interacts with multiple genes. One of these interaction partners is identified in the literature as a deubiquitinase that acts as a central coor... | |
medium_divergent_branch_04055 | NCAPG interacts with multiple proteins. One interaction is supported by evidence stating: 'The human 13S complex has exactly the same composition as its Xenopus counterpart, being composed of two structural maintenance of chromosomes (human chromosome-associated polypeptide (hCAP)-C and hCAP-E) subunits and three non-s... | Condensin complex subunit 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04055","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NCAPG interacts with multiple proteins. One interaction is supported by evidence stating: 'The human 13S complex has exactly the same composition as ... | |
medium_divergent_branch_04056 | PPARG interacts with multiple proteins. One interaction is supported by evidence stating: 'We show that putative PPAR ligands enhance the interaction of a nuclear receptor corepressor with the rat PPAR subtypes alpha and gamma in solution but not with PPAR/RXR heterodimers on DNA.' Which protein, encoded by the gene co... | Nuclear receptor-interacting protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04056","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PPARG interacts with multiple proteins. One interaction is supported by evidence stating: 'We show that putative PPAR ligands enhance the interaction... | |
medium_divergent_branch_04057 | The biological process 'regulation of lamellocyte differentiation' is a subtype of a broader regulatory process. Evidence for this relationship notes that lamellocytes are large flat cells that differentiate massively in the lymph glands after parasitization to encapsulate invaders too large for plasmatocytes to phagoc... | hemocyte differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04057","source_qa_id":"medium_divergent_branch_07371","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'regulation of lamellocyte differentiation' is a subtype of a broader regu... | |
medium_divergent_branch_04058 | CLPP interacts with multiple proteins. One interaction partner forms a complex characterized by a double heptameric ring of hClpP with hexameric hClpX rings bound on each side, which remains stable in the presence of ATP or adenosine 5'-(3-thiotriphosphate) (ATPgammaS), indicating that a symmetry mismatch is a universa... | protoporphyria, erythropoietic, 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04058","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CLPP interacts with multiple proteins. One interaction partner forms a complex characterized by a double heptameric ring of hClpP with hexameric hClp... | |
medium_divergent_branch_04059 | MAPKAP1 interacts with multiple proteins. One of these interaction partners is implicated in a mechanism where genetic ablation of SIN1 abolishes Akt-Ser473 phosphorylation and disrupts the interaction between this partner and Rictor, while maintaining Thr308 phosphorylation. Which protein is encoded by the gene corres... | Serine/threonine-protein kinase mTOR | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04059","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAPKAP1 interacts with multiple proteins. One of these interaction partners is implicated in a mechanism where genetic ablation of SIN1 abolishes Akt... | |
medium_divergent_branch_04060 | HDAC6 is associated with multiple molecular functions via the 'enables' relationship. One specific function is supported by evidence stating: 'We demonstrate that HDAC6 has the capacity to bind both polyubiquitinated misfolded proteins and dynein motors, thereby acting to recruit misfolded protein cargo to dynein motor... | dynein complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04060","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HDAC6 is associated with multiple molecular functions via the 'enables' relationship. One specific function is supported by evidence stating: 'We dem... | |
medium_divergent_branch_04061 | CALM1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In vitro binding experiments reveal a direct, robust interaction between a centriolar protein and CaM and the existence of multiple high-affinity CaM-binding domains in this protein.' Which protein, connected to CALM1 via an inte... | Centriolar coiled-coil protein of 110 kDa | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04061","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CALM1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In vitro binding experiments reveal a direct, robust inter... | |
medium_divergent_branch_04062 | ACSL4 interacts with multiple proteins. One specific interaction involves a protein that directly binds to and phosphorylates ACSL4 at serine 447, subsequently recruiting an E3 ubiquitin ligase to polyubiquitinate ACSL4 at lysines 388, 498, and 690, leading to its degradation. Which protein is connected to the gene ACS... | E3 ubiquitin-protein ligase UBR5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04062","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ACSL4 interacts with multiple proteins. One specific interaction involves a protein that directly binds to and phosphorylates ACSL4 at serine 447, su... | |
medium_divergent_branch_04064 | NELFA interacts with multiple proteins. One interaction is supported by evidence stating that NELF-B and NELF-C or NELF-D are integral subunits that bring NELF-A and a specific partner protein together, and that coexpression of these four proteins in insect cells reconstituted functionally active NELF. Which protein, c... | Negative elongation factor E | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04064","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NELFA interacts with multiple proteins. One interaction is supported by evidence stating that NELF-B and NELF-C or NELF-D are integral subunits that ... | |
medium_divergent_branch_04065 | WDR62 interacts with multiple genes. One of these interacting partners is described as a ubiquitously expressed, heat-sensitive 175-kDa protein that specifically associates with JNK but not with ERK or p38. Which cell type is enriched for the gene corresponding to this specific interacting partner? | basophil | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04065","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WDR62 interacts with multiple genes. One of these interacting partners is described as a ubiquitously expressed, heat-sensitive 175-kDa protein that ... | |
medium_divergent_branch_04067 | EPB41L2 interacts with multiple genes. One of these interaction partners is bound by circEPB41L2, which acts as a scaffold linking the partner's RRM1 domain to the E3 ubiquitin ligase TRIP12, thereby promoting the partner's polyubiquitylation and degradation. Which disease is associated with this specific interaction p... | hypercholesterolemia, familial, 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04067","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EPB41L2 interacts with multiple genes. One of these interaction partners is bound by circEPB41L2, which acts as a scaffold linking the partner's RRM1... | |
medium_divergent_branch_04068 | TNF is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'By measuring the binding of a panel of mTNF/hTNF chimeras to both mTNF-R, we pinpointed the TNF region that mediates the interaction with mTNF-RII.' Which protein, connected to TNF via this binding interaction, ... | Tumor necrosis factor receptor superfamily member 1B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04068","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TNF is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'By measuring the binding of a panel of m... | |
medium_divergent_branch_04069 | The gene RPS14 is associated with multiple biological processes. One association is supported by evidence stating that 'Chinese hamster ribosomal protein S14 cDNA was used to recognize homologous human cDNA and genomic clones.' Identify the biological process linked to this specific association via an 'is a' relationsh... | translation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04069","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene RPS14 is associated with multiple biological processes. One association is supported by evidence stating that 'Chinese hamster ribosomal pro... | |
medium_divergent_branch_04070 | The gene NAGA is enriched in multiple immune cell types. One specific cell type shows a mean expression of 200.59 TPM, a z-score of 1.67, and a fold enrichment of 4.22. Which cell type, defined by these expression statistics, is a subtype of monocytes? | monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04070","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene NAGA is enriched in multiple immune cell types. One specific cell type shows a mean expression of 200.59 TPM, a z-score of 1.67, and a fold ... | |
medium_divergent_branch_04071 | CARMIL1 is involved in multiple biological processes. One of these processes is supported by evidence stating that both CARMIL1 and CARMIL2 isoforms are necessary for it. Which biological process is a parent term (via 'is a') of this specific process? | cell motility | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04071","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CARMIL1 is involved in multiple biological processes. One of these processes is supported by evidence stating that both CARMIL1 and CARMIL2 isoforms ... | |
medium_divergent_branch_04072 | SNAI1 interacts with multiple proteins. One specific interaction partner is characterized by a breast cancer-associated R64Q mutation that abolishes its binding to Snail and prevents the Snail-mediated ubiquitination and degradation process. Which protein is encoded by the gene corresponding to this interaction partner... | E3 ubiquitin-protein ligase TRIM21 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04072","source_qa_id":"medium_divergent_branch_02660","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"SNAI1 interacts with multiple proteins. One specific interaction partner is characterized by a br... | |
medium_divergent_branch_04073 | SKP2 interacts with multiple genes. One interaction is supported by evidence stating that curcumol enhanced the interaction between a cadherin family member and SKP2, leading to the ubiquitination and degradation of SKP2. Which cell type is the gene involved in this specific interaction enriched in? | plasmacytoid dendritic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04073","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SKP2 interacts with multiple genes. One interaction is supported by evidence stating that curcumol enhanced the interaction between a cadherin family... | |
medium_divergent_branch_04074 | CD74 is associated with multiple cellular components via the 'located in' relationship. One association is supported by evidence stating: 'We demonstrate that CD74/CXCR4 complexes formed when CD74 was expressed with CXCR4 in HEK293 cells.' Which of the candidate cellular components is connected to CD74 through the 'is ... | cellular_component | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04074","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CD74 is associated with multiple cellular components via the 'located in' relationship. One association is supported by evidence stating: 'We demonst... | |
medium_divergent_branch_04076 | AMFR interacts with multiple proteins. One of these interaction partners is described in co-immunoprecipitation studies as bridging SPFH2 to gp78 in ER membranes. Which protein corresponds to this specific interaction partner? | Transmembrane and ubiquitin-like domain-containing protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04076","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AMFR interacts with multiple proteins. One of these interaction partners is described in co-immunoprecipitation studies as bridging SPFH2 to gp78 in ... | |
medium_divergent_branch_04077 | The gene CGAS (MB21D1) interacts with multiple proteins. Evidence for one specific interaction indicates that it depends on the cGAS C-terminal domain and the RRC1-4 and RRC1-5 domains of the interacting partner. Which protein, encoded by the gene connected to CGAS via this specific interaction, is the subject of this ... | E3 ISG15--protein ligase HERC5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04077","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CGAS (MB21D1) interacts with multiple proteins. Evidence for one specific interaction indicates that it depends on the cGAS C-terminal domai... |
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