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medium_divergent_branch_04078 | PRKCE interacts with multiple genes. One interaction is supported by evidence stating: 'This method identified myosin IIA in PKC epsilon immunoprecipitates, as well as known PKC epsilon binding proteins, actin, a coatomer subunit and cytokeratin.' Which disease is associated with the gene identified in this specific ev... | scleroderma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04078","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRKCE interacts with multiple genes. One interaction is supported by evidence stating: 'This method identified myosin IIA in PKC epsilon immunoprecip... | |
medium_divergent_branch_04079 | DBF4 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We also identified an interaction between MCM-BP and the Dbf4 regulatory component of the DDK kinase in both yeast 2-hybrid and insect cell co-expression assays, and this interaction was verified by co-immunoprecipitation... | DNA replication licensing factor MCM4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04079","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DBF4 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We also identified an interaction between MCM-BP a... | |
medium_divergent_branch_04080 | STX1A interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we demonstrate that granuphilin directly binds to syntaxin 1a on the plasma membrane, and this interaction is regulated by Rab27a.' Which protein, encoded by the gene connected to STX1A via this specific interaction... | Synaptotagmin-like protein 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04080","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"STX1A interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we demonstrate that granuphilin directly bin... | |
medium_divergent_branch_04081 | POU2F1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Unexpectedly, a similar interaction with Ku was observed for several additional homeodomain proteins including octamer transcription factors 1 and 2 and Dlx2, suggesting that specific binding to Ku may be a property share... | alcohol abuse | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04081","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"POU2F1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Unexpectedly, a similar interaction with Ku was ob... | |
medium_divergent_branch_04082 | BIN1 interacts with multiple proteins. One specific interaction is described by the evidence: 'We identified [interacting partner] as an amphiphysin 2/BIN1-interacting molecule.' Which protein is encoded by the gene corresponding to this interacting partner? | CAP-Gly domain-containing linker protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04082","source_qa_id":"medium_divergent_branch_03491","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"BIN1 interacts with multiple proteins. One specific interaction is described by the evidence: 'We... | |
medium_divergent_branch_04083 | MIR145 is associated with multiple biological processes. One association is supported by evidence stating: 'These data demonstrate a specific role for miR145 in the regulation of matrix gene expression in smooth muscle cells and suggest that miR145 acts to suppress TGFβ-dependent extracellular matrix accumulation and f... | extracellular matrix assembly | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04083","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR145 is associated with multiple biological processes. One association is supported by evidence stating: 'These data demonstrate a specific role fo... | |
medium_divergent_branch_04084 | STING1 interacts with multiple proteins. One of these interacting partners has been shown to bind STING and target it for lysine 63-linked ubiquitination. Which protein, encoded by the gene corresponding to this specific interacting partner, is the subject of this description? | E3 ubiquitin-protein ligase TRIM56 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04084","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"STING1 interacts with multiple proteins. One of these interacting partners has been shown to bind STING and target it for lysine 63-linked ubiquitina... | |
medium_divergent_branch_04085 | SENP1 interacts with multiple proteins. One interaction is supported by structural evidence describing the determination of structures of catalytically inactive SENP1 bound to a SUMO family protein-modified RanGAP1 and to unprocessed SUMO family protein. Which protein, connected to SENP1 via this specific structural ev... | Small ubiquitin-related modifier 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04085","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SENP1 interacts with multiple proteins. One interaction is supported by structural evidence describing the determination of structures of catalytical... | |
medium_divergent_branch_04086 | ARF4 is associated with multiple biological processes. One association is supported by evidence showing that overexpression of ARF4 in Yeast or U373MG cells reduces reactive oxygen species (ROS) generation in response to Bax or N-(4-hydroxyphenyl)retinamide (4-HPR), respectively, suggesting a role in inhibiting cell de... | reactive oxygen species metabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04086","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARF4 is associated with multiple biological processes. One association is supported by evidence showing that overexpression of ARF4 in Yeast or U373M... | |
medium_divergent_branch_04087 | RAD23A interacts with multiple proteins. One specific interaction involves a protein described as an essential mediator of RIG-I/MDA5 signaling, which is down-regulated by RAD23A through the ubiquitin-proteasome system. Which protein is encoded by the gene corresponding to this interacting partner? | TNF receptor-associated factor 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04087","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAD23A interacts with multiple proteins. One specific interaction involves a protein described as an essential mediator of RIG-I/MDA5 signaling, whic... | |
medium_divergent_branch_04088 | BCL9 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we identify four conserved residues at the putative PHD domain surface of Drosophila and mouse Pygopus that are required for their binding to Legless in vitro and in vivo.' Which molecular function is enabled by the protein ... | histone H3K4me3 reader activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04088","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BCL9 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we identify four conserved residues at the putative P... | |
medium_divergent_branch_04089 | The gene TOB1 interacts with multiple proteins. One specific interaction involves a protein that phosphorylates Tob, thereby inhibiting its degradation via the Cul4-DDB1(Cdt2) pathway. Which protein is encoded by the gene that interacts with TOB1 in this specific manner? | Cell division cycle 7-related protein kinase | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04089","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TOB1 interacts with multiple proteins. One specific interaction involves a protein that phosphorylates Tob, thereby inhibiting its degradati... | |
medium_divergent_branch_04090 | KIF7 interacts with multiple proteins. One of these interaction partners is described in a study stating: 'We show that PPFIA1 (liprin-α1), KLHL11, KIF7 and ERC2 are substrates for ubiquitination by this protein.' Which protein, encoded by the gene corresponding to this interaction partner, is connected to KIF7? | E3 ubiquitin-protein ligase LNX | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04090","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KIF7 interacts with multiple proteins. One of these interaction partners is described in a study stating: 'We show that PPFIA1 (liprin-α1), KLHL11, K... | |
medium_divergent_branch_04091 | The gene FAM175B is known to interact with multiple partners. One specific interaction partner is supported by evidence stating: 'Furthermore, confocal microscopy and coimmunoprecipitation assay showed that the protein encoded by the gene interacting with FAM175B colocalized and interacted with FAM175B.' Based on this ... | Cyclic AMP-dependent transcription factor ATF-4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04091","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene FAM175B is known to interact with multiple partners. One specific interaction partner is supported by evidence stating: 'Furthermore, confoc... | |
medium_divergent_branch_04092 | PRKG1 is reported to interact with multiple genes. One specific interaction is supported by evidence stating: 'The skTnT protein interacted with cGK Ibeta but not with cGK II nor cAMP-dependent protein kinase.' Which disease is linked to the gene identified by this specific interaction evidence via the relation 'genomi... | nemaline myopathy 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04092","source_qa_id":"medium_divergent_branch_04585","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"PRKG1 is reported to interact with multiple genes. One specific interaction is supported by evide... | |
medium_divergent_branch_04094 | SIAH2 is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence that silencing SIAH2 or POSH in prostate cancer cells results in increased caspase activity and apoptosis in response to both TRAIL and Fas ligand. Which biological process is neg... | extrinsic apoptotic signaling pathway | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04094","source_qa_id":"medium_divergent_branch_04990","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"SIAH2 is associated with multiple biological processes via the 'involved in' relationship. One sp... | |
medium_divergent_branch_04095 | The gene P2RY11 is enriched in multiple cell types. One specific cell type shows a mean expression of 19.20 TPM, a z-score of 2.17, and a fold enrichment of 6.33. Which cell type corresponds to these expression statistics, and what is its immediate parent category in the cell type hierarchy (i.e., what is it a subtype ... | mature alpha-beta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04095","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene P2RY11 is enriched in multiple cell types. One specific cell type shows a mean expression of 19.20 TPM, a z-score of 2.17, and a fold enrich... | |
medium_divergent_branch_04096 | TRAF3 interacts with multiple genes. One interaction partner is characterized by evidence stating that it, along with MUL, is capable of binding in vitro via their TRAF-binding domains (TDs) to all previously identified TRAF family proteins (TRAF1, TRAF2, TRAF3, TRAF4, TRAF5, and TRAF6), whereas the TD of SPOP interact... | intellectual disability | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04096","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRAF3 interacts with multiple genes. One interaction partner is characterized by evidence stating that it, along with MUL, is capable of binding in v... | |
medium_divergent_branch_04097 | MAP1LC3B interacts with multiple proteins. One specific interaction partner is characterized by evidence stating: 'Direct binding of the retromer component VPS29 to this protein could be titrated out by LC3, indicating a molecular switch between endosomes and autophagy.' What is the name of the protein encoded by this ... | TBC1 domain family member 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04097","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP1LC3B interacts with multiple proteins. One specific interaction partner is characterized by evidence stating: 'Direct binding of the retromer com... | |
medium_divergent_branch_04098 | MXI1 interacts with multiple proteins. One specific interaction is characterized by the finding that the partner protein targets Mxi1 for ubiquitination and degradation at the K46 residue. Which protein, connected to MXI1 via this specific interaction, is encoded by the gene in question? | (E3-independent) E2 ubiquitin-conjugating enzyme | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04098","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MXI1 interacts with multiple proteins. One specific interaction is characterized by the finding that the partner protein targets Mxi1 for ubiquitinat... | |
medium_divergent_branch_04099 | IRAK1 interacts with multiple proteins. One specific interaction is characterized by the following evidence: 'Here we show that, before IL-1beta treatment, this protein is present in a complex with IRAK, and that recruitment of this protein-IRAK complexes to the activated receptor complex occurs through association of ... | Toll-interacting protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04099","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IRAK1 interacts with multiple proteins. One specific interaction is characterized by the following evidence: 'Here we show that, before IL-1beta trea... | |
medium_divergent_branch_04100 | ICAM1 interacts with multiple proteins. One specific interaction is characterized by the following mechanism: the interacting partner undergoes autoubiquitination and clearance, which stabilizes LRP6, activates β-catenin signaling, and subsequently upregulates PD-L1 expression. Which protein corresponds to this mechani... | E3 ubiquitin-protein ligase ZNRF3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04100","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ICAM1 interacts with multiple proteins. One specific interaction is characterized by the following mechanism: the interacting partner undergoes autou... | |
medium_divergent_branch_04101 | ERCC5 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using coimmunoprecipitation experiments, we showed that this activity involves the interaction between the N-terminal domain of a protein encoded by GTF2H1 and the 3' endonuclease XPG, a major component of the nucleotide excision... | General transcription factor IIH subunit 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04101","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ERCC5 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using coimmunoprecipitation experiments, we showed that th... | |
medium_divergent_branch_04103 | CARD14 interacts with multiple proteins. One interaction partner is a signaling protein whose CARD domain associates specifically with the CARD domains of both CARD11 and CARD14. This protein activates NF-kappaB through the IkappaB kinase complex in response to upstream stimuli. Which protein is encoded by the gene cor... | B-cell lymphoma/leukemia 10 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04103","source_qa_id":"medium_divergent_branch_04819","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"CARD14 interacts with multiple proteins. One interaction partner is a signaling protein whose CAR... | |
medium_divergent_branch_04104 | SERP1 interacts with multiple proteins. One interaction is supported by evidence stating: 'By coimmunprecipitation and colocalisation experiments, we were able to demonstrate evidence for the interaction of these proteins.' Which protein, connected to SERP1 via this specific evidence, is encoded by the gene in question... | Vitamin K epoxide reductase complex subunit 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04104","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SERP1 interacts with multiple proteins. One interaction is supported by evidence stating: 'By coimmunprecipitation and colocalisation experiments, we... | |
medium_divergent_branch_04105 | ATM interacts with multiple genes. One of these interacting partners is reported to co-immunoprecipitate with Ku70/86 (the DNA binding subunits of DNA-PK) in the nucleoplasm, an association that is diminished by vanillin. Which disease is connected to this specific interacting gene through a biomarker relationship? | alcohol abuse | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04105","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATM interacts with multiple genes. One of these interacting partners is reported to co-immunoprecipitate with Ku70/86 (the DNA binding subunits of DN... | |
medium_divergent_branch_04106 | The gene FLII is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 42.06 TPM, a z-score of 1.65, and a fold enrichment of 2.02. Which cell type, connected to FLII via this specific enrichment profile, develops from another monocyte subtype? | classical monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04106","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene FLII is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 42.06 TPM, a z-score of 1... | |
medium_divergent_branch_04107 | DERL1 interacts with multiple genes. One interaction is supported by the statement: 'In this study we demonstrate that Derlin-1 interacts with the N-terminal domain of PNGase via its cytosolic C-terminus.' Which disease is associated with the gene identified by this evidence through a biomarker relationship? | scoliosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04107","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DERL1 interacts with multiple genes. One interaction is supported by the statement: 'In this study we demonstrate that Derlin-1 interacts with the N-... | |
medium_divergent_branch_04108 | The protein encoded by the MDFI gene interacts with multiple partners. One specific interaction involves I-mf associating with MyoD family members to retain them in the cytoplasm by masking their nuclear localization signals. Which gene, connected to the partner identified by this evidence, is linked via a 'binds' rela... | TCF3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04108","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein encoded by the MDFI gene interacts with multiple partners. One specific interaction involves I-mf associating with MyoD family members to... | |
medium_divergent_branch_04109 | IRF7 is involved in multiple biological processes. One specific connection is supported by evidence stating: 'Here we report that the overexpression of a constitutively active form of IRF-7 binds and positively regulates the transcriptional activity of the promotor of IRF-1 and low molecular mass polypeptide-2 (LMP-2),... | adaptive immune response | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04109","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IRF7 is involved in multiple biological processes. One specific connection is supported by evidence stating: 'Here we report that the overexpression ... | |
medium_divergent_branch_04111 | The gene RAN interacts with multiple proteins. One of these interaction partners is described as a transport receptor that binds specifically to RanGTP, interacts with nucleoporins, and shuttles between the nuclear and cytoplasmic compartments. Which protein is encoded by the gene corresponding to this specific interac... | Exportin-5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04111","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene RAN interacts with multiple proteins. One of these interaction partners is described as a transport receptor that binds specifically to RanG... | |
medium_divergent_branch_04112 | FBLN1 is associated with multiple biological processes. One association is supported by evidence showing that FBLN1 increases mitochondrial activity and proliferation in fibroblasts. Which biological process, connected to the process supported by this evidence via a 'positively regulates' relationship, is the target of... | fibroblast proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04112","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBLN1 is associated with multiple biological processes. One association is supported by evidence showing that FBLN1 increases mitochondrial activity ... | |
medium_divergent_branch_04113 | BMP10 is associated with multiple biological processes. One such association is supported by evidence stating: 'The data presented here suggest that BMP-10 plays an important role in trabeculation of the embryonic heart.' Identify the anatomical structure that is the result of the morphogenesis process linked to this s... | cardiac muscle tissue of ventricle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04113","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BMP10 is associated with multiple biological processes. One such association is supported by evidence stating: 'The data presented here suggest that ... | |
medium_divergent_branch_04114 | RUFY1 interacts with multiple proteins. One interaction is supported by evidence stating: 'An interactor screen for proteins that function together with rabip4' yielded the adaptor protein complex AP-3, of which the hinge region in the β3 subunit bound directly to the FYVE domain of rabip4'.' Which protein, connected t... | AP-3 complex subunit beta-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04114","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RUFY1 interacts with multiple proteins. One interaction is supported by evidence stating: 'An interactor screen for proteins that function together w... | |
medium_divergent_branch_04115 | IBTK interacts with multiple genes. One of these interaction partners is a target of IBTK, which acts as an inhibitor by binding to the PH domain of this partner. Which disease is associated with this specific interaction partner via a biomarker relationship? | Hereditary factor VIII deficiency disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04115","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IBTK interacts with multiple genes. One of these interaction partners is a target of IBTK, which acts as an inhibitor by binding to the PH domain of ... | |
medium_divergent_branch_04118 | HiNF-P interacts with multiple proteins. One interaction is described by the statement: 'Here we demonstrate that HiNF-P, a transcriptional regulator of replication-dependent histone H4 genes, interacts directly with a substrate of cyclin E/CDK2, to coactivate histone genes during S phase.' Which protein, encoded by th... | Protein NPAT | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04118","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HiNF-P interacts with multiple proteins. One interaction is described by the statement: 'Here we demonstrate that HiNF-P, a transcriptional regulator... | |
medium_divergent_branch_04119 | AKAP11 interacts with multiple proteins. One interaction is supported by evidence stating: 'Immunoprecipitation of AKAP 220 from rat testis extracts resulted in co-purification of the type II PKA holoenzyme.' Which protein, encoded by the gene involved in this specific interaction, is the target of the 'encodes' relati... | cAMP-dependent protein kinase type II-alpha regulatory subunit | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04119","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AKAP11 interacts with multiple proteins. One interaction is supported by evidence stating: 'Immunoprecipitation of AKAP 220 from rat testis extracts ... | |
medium_divergent_branch_04120 | PRIMPOL interacts with multiple genes. One of these interacting partners possesses primase and DNA polymerase activities in vitro, interacts directly with PRIMPOL, and is recruited to sites of DNA damage and stalled replication forks in a manner dependent on this partner. Which disease is associated with this specific ... | pulmonary fibrosis and/or bone marrow failure, telomere-related, 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04120","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRIMPOL interacts with multiple genes. One of these interacting partners possesses primase and DNA polymerase activities in vitro, interacts directly... | |
medium_divergent_branch_04121 | FBXO8 interacts with multiple genes. One of these interaction partners is directly targeted by FBXO8 for ubiquitin-mediated proteasome degradation in colorectal cancer (CRC). Which protein is encoded by this specific interaction partner? | Glutathione S-transferase P | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04121","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBXO8 interacts with multiple genes. One of these interaction partners is directly targeted by FBXO8 for ubiquitin-mediated proteasome degradation in... | |
medium_divergent_branch_04122 | GTF3C2 interacts with multiple genes. One interaction is supported by evidence stating: 'Pull down and coimmunoprecipitation experiments as well as functional assays indicate that the retinoblastoma protein interacts with both TFIIIB and TFIIIC2 and that the A subdomain is primarily required for binding TFIIIB and the ... | naive B cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04122","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GTF3C2 interacts with multiple genes. One interaction is supported by evidence stating: 'Pull down and coimmunoprecipitation experiments as well as f... | |
medium_divergent_branch_04123 | PHLPP1 is reported to interact with multiple genes. One specific interaction involving PHLPP1 was experimentally validated using immunoprecipitation and GST pull-down assays. Which gene, among those interacting with PHLPP1, is the subject of this specific experimental evidence, and subsequently binds to another partner... | WDR48 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04123","source_qa_id":"medium_divergent_branch_06802","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"PHLPP1 is reported to interact with multiple genes. One specific interaction involving PHLPP1 was... | |
medium_divergent_branch_04124 | NUMA1 is associated with multiple biological processes. One association is supported by evidence stating: 'These results indicate that the NuMA proteins may be a structural component of the nucleus and may be involved in the early steps of nuclear reformation during telophase.' Identify the biological process described... | organelle organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04124","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NUMA1 is associated with multiple biological processes. One association is supported by evidence stating: 'These results indicate that the NuMA prote... | |
medium_divergent_branch_04125 | The gene TRAPPC10 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 11.73 TPM, a z-score of 1.83, and a fold enrichment of 3.31. Which cell type corresponds to this specific expression profile, and what is its direct parent category in the cell type... | mature alpha-beta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04125","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TRAPPC10 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 11.73 TPM,... | |
medium_divergent_branch_04126 | ANK1 interacts with multiple genes. One specific interaction is described by the following evidence: 'The 89 kDa NH2-terminal domain of erythrocyte ankyrin is composed almost entirely of 22 tandem repeats of a 33 amino acid sequence and constitutes the binding site for the cytoplasmic NH2-terminal domain of the erythro... | preeclampsia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04126","source_qa_id":"medium_divergent_branch_05865","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ANK1 interacts with multiple genes. One specific interaction is described by the following eviden... | |
medium_divergent_branch_04127 | DAPK1 interacts with multiple proteins. One specific interaction is characterized by DAPK binding to ERK via a docking sequence within its death domain, where DAPK serves as a substrate for ERK. Which protein, connected to DAPK1 through this specific interaction, is encoded by the gene in question? | Mitogen-activated protein kinase 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04127","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DAPK1 interacts with multiple proteins. One specific interaction is characterized by DAPK binding to ERK via a docking sequence within its death doma... | |
medium_divergent_branch_04128 | The protein LETM1 is associated with multiple biological processes. One specific association is supported by evidence stating that 'RNAi knockdown, overexpression, and liposome reconstitution of the purified Letm1 protein demonstrate that Letm1 is a mitochondrial Ca2+/H+ antiporter.' Which biological process, connected... | calcium ion transmembrane transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04128","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein LETM1 is associated with multiple biological processes. One specific association is supported by evidence stating that 'RNAi knockdown, o... | |
medium_divergent_branch_04129 | Interleukin-17 production is enabled by multiple cell types. One specific cell type involved is described as a circulating gamma-delta T cell that expresses RORgamma(t), is CD27-negative, and is capable of IL-17 secretion. What is the immediate parent class (is_a relationship) of this specific cell type? | mature gamma-delta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04129","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Interleukin-17 production is enabled by multiple cell types. One specific cell type involved is described as a circulating gamma-delta T cell that ex... | |
medium_divergent_branch_04131 | Melanocytes are anatomically associated with multiple structures via a 'part of' relationship. One such association is supported by evidence describing 'The deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells.' Which anatomical structure is connected to the melanocyte through th... | skin epidermis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04131","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Melanocytes are anatomically associated with multiple structures via a 'part of' relationship. One such association is supported by evidence describi... | |
medium_divergent_branch_04132 | The glucocorticoid receptor (NR3C1) interacts with multiple components of the SWI-SNF chromatin remodeling complex. One specific interaction involves a subunit where mutations affecting transactivation activity in vivo also directly disrupt the interaction with the SWI-SNF complex. Which disease is associated with this... | arteriosclerosis disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04132","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The glucocorticoid receptor (NR3C1) interacts with multiple components of the SWI-SNF chromatin remodeling complex. One specific interaction involves... | |
medium_divergent_branch_04133 | FLNC interacts with multiple proteins. One interaction partner is described as SEK-1, a dual specificity protein kinase that serves as an immediate upstream activator of stress-activated protein kinases (SAPKs) and associates specifically with the actin-binding protein ABP-280. Which protein is encoded by the gene corr... | Dual specificity mitogen-activated protein kinase kinase 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04133","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FLNC interacts with multiple proteins. One interaction partner is described as SEK-1, a dual specificity protein kinase that serves as an immediate u... | |
medium_divergent_branch_04134 | SFRP1 is associated with multiple biological processes. One association is supported by evidence stating: 'Interestingly, SFRP-1 reduced the number of multipotent progenitors in in vitro culture of CD34(-)KSL cells, while SFRP-2 did not.' Which cell type is the result of the biological process linked to this evidence, ... | hematopoietic stem cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04134","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SFRP1 is associated with multiple biological processes. One association is supported by evidence stating: 'Interestingly, SFRP-1 reduced the number o... | |
medium_divergent_branch_04135 | RANGAP1 interacts with multiple proteins. One interaction is supported by evidence stating: 'The RanBP2 nucleoporin contains an internal repeat domain (IR1-M-IR2) that catalyzes E3 ligase activity and forms a stable complex with SUMO-modified RanGAP1 and the SUMO E2-conjugating enzyme at the nuclear pore complex.' Whic... | osteosarcoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04135","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RANGAP1 interacts with multiple proteins. One interaction is supported by evidence stating: 'The RanBP2 nucleoporin contains an internal repeat domai... | |
medium_divergent_branch_04136 | GSTP1 interacts with multiple proteins. One of these interactions is characterized by evidence stating that the two entities can directly bind to and regulate each other. Which protein, connected to GSTP1 via this specific interaction, is the gene that encodes the protein in question? | Signal transducer and activator of transcription 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04136","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GSTP1 interacts with multiple proteins. One of these interactions is characterized by evidence stating that the two entities can directly bind to and... | |
medium_divergent_branch_04137 | SOX9 is associated with multiple biological processes. One specific process is supported by evidence stating that nonsense and frameshift mutations in SOX9, found in patients with campomelic dysplasia or sex reversal, lead to truncation of the transactivation (TA) domain. This suggests that the impairment of gonadal an... | testis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04137","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SOX9 is associated with multiple biological processes. One specific process is supported by evidence stating that nonsense and frameshift mutations i... | |
medium_divergent_branch_04139 | KCNJ1 (ROMK) interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Immunoprecipitation of renal tissue lysate with ROMK antibody and glutathione S-transferase pulldown experiments demonstrated the association between ROMK and a protein encoded by the gene SH3RF1.' Which disease i... | invasive breast carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04139","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KCNJ1 (ROMK) interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Immunoprecipitation of renal tissue lysate... | |
medium_divergent_branch_04140 | The supporting cell of the vestibular epithelium is a component of a specific anatomical structure. One piece of evidence describing this relationship explicitly states: 'A supporting cell of the vestibular epithelium.' Based on this textual evidence, which anatomical structure is the supporting cell of the vestibular ... | membranous labyrinth | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04140","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The supporting cell of the vestibular epithelium is a component of a specific anatomical structure. One piece of evidence describing this relationshi... | |
medium_divergent_branch_04141 | FANCD2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here, we identify a novel interaction partner of FANCD2.' Which disease is causally linked to the gene that interacts with FANCD2 in this specific context? | hypersensitivity reaction disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04141","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FANCD2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here, we identify a novel interaction partner of FA... | |
medium_divergent_branch_04142 | SMAD4 interacts with multiple proteins. One specific interaction is supported by evidence stating that 'Yeast two-hybrid analysis showed that WWOX acts as a bridge to bind both Hyal-2 and Smad4.' Which protein, connected to SMAD4 via this interaction, is encoded by the gene in question? | Hyaluronidase-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04142","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMAD4 interacts with multiple proteins. One specific interaction is supported by evidence stating that 'Yeast two-hybrid analysis showed that WWOX ac... | |
medium_divergent_branch_04144 | EHD1 interacts with multiple genes. One interaction is supported by evidence stating: 'We have now identified [a specific gene] as an interaction partner for the recycling regulatory protein, Eps15 homology domain 1 (EHD1).' Which gene, connected to EHD1 via this specific interaction, is linked to another gene through ... | RHOD | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04144","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EHD1 interacts with multiple genes. One interaction is supported by evidence stating: 'We have now identified [a specific gene] as an interaction par... | |
medium_divergent_branch_04147 | The gene PLA2G4A interacts with multiple partners. One interaction is characterized by the following observation: 'In contrast, whereas annexin II and cPLA2 interacted at a constant rate, the protein encoded by the interacting gene and cPLA2 interacted more strongly in stationary cells, thus indicating that cPLA2 activ... | Protein S100-A10 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04147","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PLA2G4A interacts with multiple partners. One interaction is characterized by the following observation: 'In contrast, whereas annexin II an... | |
medium_divergent_branch_04148 | The gene RETREG1 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 9.51 TPM, a z-score of 1.90, and a fold enrichment of 4.38. Which cell type is the developmental precursor (connected via 'develops from') to the cell type exhibiting this specific expression p... | mature CD4 single-positive thymocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04148","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene RETREG1 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 9.51 TPM, a z-score of... | |
medium_divergent_branch_04149 | GNG2 interacts with multiple genes. One interaction is supported by evidence stating: 'Furthermore, we demonstrated Gbetagamma to interact directly with the N-terminal region of a specific gene product and the N-terminal fragment of this molecule to inhibit serum response element-dependent transcription induced by Gbet... | leukodystrophy and acquired microcephaly with or without dystonia; | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04149","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GNG2 interacts with multiple genes. One interaction is supported by evidence stating: 'Furthermore, we demonstrated Gbetagamma to interact directly w... | |
medium_divergent_branch_04150 | The gene FYN interacts with multiple partners. One specific interaction is supported by evidence stating: 'Finally, in vivo experiments showed that the protein product of the gene associated with Wiskott-Aldrich syndrome and Fyn physically associate in human haematopoietic cells.' Which disease is associated with the g... | severe congenital neutropenia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04150","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene FYN interacts with multiple partners. One specific interaction is supported by evidence stating: 'Finally, in vivo experiments showed that t... | |
medium_divergent_branch_04151 | PRKCA interacts with multiple proteins. One of these interaction partners is supported by evidence stating: 'We also provide evidence that PKCalpha and PKCtheta can physically associate with this protein and are able to phosphorylate it in vitro and in vivo.' What is the name of the protein encoded by this gene? | E3 ubiquitin-protein ligase CBL | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04151","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRKCA interacts with multiple proteins. One of these interaction partners is supported by evidence stating: 'We also provide evidence that PKCalpha a... | |
medium_divergent_branch_04152 | ITPR1 interacts with multiple genes. One of these interacting partners was shown to associate with both IP3R and TRPC1 upon activation with thrombin. Which disease is connected to this specific interacting gene through a biomarker relationship? | alopecia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04152","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ITPR1 interacts with multiple genes. One of these interacting partners was shown to associate with both IP3R and TRPC1 upon activation with thrombin.... | |
medium_divergent_branch_04153 | GRK5 is associated with multiple biological processes. One association is supported by evidence that GRK5 phosphorylates the beta 2-adrenergic receptor, m2 muscarinic cholinergic receptor, and rhodopsin in an agonist-dependent manner. Which broader biological process is a parent category (via an 'is a' relationship) of... | regulation of signal transduction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04153","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GRK5 is associated with multiple biological processes. One association is supported by evidence that GRK5 phosphorylates the beta 2-adrenergic recept... | |
medium_divergent_branch_04154 | EME1 interacts with multiple proteins. One of these interaction partners is described as forming a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associating with the MSH2/MSH3 mismatch repair complex, the telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kina... | Structure-specific endonuclease subunit SLX4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04154","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EME1 interacts with multiple proteins. One of these interaction partners is described as forming a multiprotein complex with the ERCC4(XPF)-ERCC1, MU... | |
medium_divergent_branch_04155 | HDAC3 interacts with multiple transcription factors. One specific interaction is characterized by evidence stating that the partner protein represses transcription when tethered to a promoter and binds HDAC3. Which disease is associated with this specific partner gene via a biomarker relationship? | carcinoma of esophagus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04155","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HDAC3 interacts with multiple transcription factors. One specific interaction is characterized by evidence stating that the partner protein represses... | |
medium_divergent_branch_04156 | PTPN11 interacts with multiple genes. One specific interaction is supported by evidence showing that Co-immunoprecipitations of SHP-2 and c-Cbl from primary T helper cells demonstrated that SHP-2 strongly interacts with the ubiquitin ligase c-Cbl, indicating that c-Cbl could mediate the negative signals of SHP-2. Which... | systemic lupus erythematosus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04156","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PTPN11 interacts with multiple genes. One specific interaction is supported by evidence showing that Co-immunoprecipitations of SHP-2 and c-Cbl from ... | |
medium_divergent_branch_04157 | Methoxamine interacts with multiple drugs. One of these interacting drugs is described in evidence stating that it, along with isoproterenol, procaterol, and T-1583, produced concentration-dependent relaxation of venous strips contracted by methoxamine. Which disease is this specific interacting drug indicated for? | chronic bronchitis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04157","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Methoxamine interacts with multiple drugs. One of these interacting drugs is described in evidence stating that it, along with isoproterenol, procate... | |
medium_divergent_branch_04158 | ANKRD28 interacts with multiple proteins. One specific interaction is described by the following mechanism: a protein binds the protein phosphatase 6 (PP6) complex and ubiquitylates one of its subunits, ankyrin repeat domain 28 (ANKRD28), leading to ANKRD28's lysosomal degradation. Which gene encodes the protein that p... | Ras-related protein Rab-40C | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04158","source_qa_id":"medium_divergent_branch_00093","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ANKRD28 interacts with multiple proteins. One specific interaction is described by the following ... | |
medium_divergent_branch_04159 | WWP1 interacts with multiple genes. One of these interaction partners was identified in a study where WWP1, an E3 ubiquitin ligase, was found to be a novel interacting partner for a reticulon family protein both in vitro and in vivo. Which disease is associated with this specific interacting gene? | cardiomyopathy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04159","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WWP1 interacts with multiple genes. One of these interaction partners was identified in a study where WWP1, an E3 ubiquitin ligase, was found to be a... | |
medium_divergent_branch_04160 | SOX2 is implicated in multiple biological processes. One such process is supported by evidence that LHX3 is expressed in defined regions of the sensory epithelium of the developing inner ear in a pattern overlapping that of SOX2. This SOX2 expression precedes the onset of LHX3 expression and is known to be required for... | internal ear | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04160","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SOX2 is implicated in multiple biological processes. One such process is supported by evidence that LHX3 is expressed in defined regions of the senso... | |
medium_divergent_branch_04161 | OTUD1 interacts with multiple genes. One specific interaction is characterized by OTUD1 directly binding to the partner protein and cleaving polyubiquitin chains from it, a process that activates the canonical NF-κB and MAPK pathways. Which disease is associated with this specific interacting partner through genomic al... | ulcerative colitis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04161","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"OTUD1 interacts with multiple genes. One specific interaction is characterized by OTUD1 directly binding to the partner protein and cleaving polyubiq... | |
medium_divergent_branch_04162 | ATXN10 interacts with multiple proteins. One specific interaction was identified through yeast-two-hybrid screening of a human brain cDNA library, where the G-protein beta2 subunit (Gbeta2) was found to be an ataxin 10 binding partner, a finding confirmed by coimmunoprecipitation and colocalization in mammalian cells. ... | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04162","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATXN10 interacts with multiple proteins. One specific interaction was identified through yeast-two-hybrid screening of a human brain cDNA library, wh... | |
medium_divergent_branch_04163 | Alpha-fetoprotein (AFP) interacts with multiple proteins. One interaction involves a phosphatase; evidence indicates that AFP acetylation promotes its oncogenic role by blocking binding to this phosphatase and the pro-apoptotic protein caspase-3, thereby increasing signaling for proliferation, migration, and invasion w... | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04163","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Alpha-fetoprotein (AFP) interacts with multiple proteins. One interaction involves a phosphatase; evidence indicates that AFP acetylation promotes it... | |
medium_divergent_branch_04164 | TRIM37 interacts with multiple genes. One of these interactions is supported by Co-Immunoprecipitation (Co-IP) evidence demonstrating a binding relationship between TRIM37 and a specific tumor suppressor protein. Which protein is encoded by the gene that interacts with TRIM37 via this specific Co-IP-supported connectio... | Cellular tumor antigen p53 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04164","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM37 interacts with multiple genes. One of these interactions is supported by Co-Immunoprecipitation (Co-IP) evidence demonstrating a binding relat... | |
medium_divergent_branch_04165 | ADAM10 is localized to multiple cellular components. Evidence indicates that ADAM10 is involved in L1 cleavage, a process that occurs at the cell surface and within a specific organelle. Which cell type is associated with this specific organelle via a 'part of cell' relationship? | plasma cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04165","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ADAM10 is localized to multiple cellular components. Evidence indicates that ADAM10 is involved in L1 cleavage, a process that occurs at the cell sur... | |
medium_divergent_branch_04166 | The gene MPG interacts with multiple partners. One specific interaction was validated using coimmunoprecipitation and cell imaging in a transient expression system, demonstrating that the compound PR209 interacts with neuronal PrPIPs, including FAM64A, HOXA1, PLK3, and the target protein. Which protein is encoded by th... | Major prion protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04166","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene MPG interacts with multiple partners. One specific interaction was validated using coimmunoprecipitation and cell imaging in a transient exp... | |
medium_divergent_branch_04169 | L3MBTL1 is associated with multiple biological processes. One association is supported by evidence stating: 'we found that the L3MBTL1 MBT domains compact nucleosomal arrays dependent on mono- and dimethylation of histone H4 lysine 20 and of histone H1b lysine 26.' Which biological process, connected to the process des... | cellular component organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04169","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"L3MBTL1 is associated with multiple biological processes. One association is supported by evidence stating: 'we found that the L3MBTL1 MBT domains co... | |
medium_divergent_branch_04170 | CDK5R1 is associated with multiple biological processes. One association is supported by evidence stating that Neuronal Cdc2-like kinase (Nclk) is involved in the regulation of neuronal differentiation and neuro-cytoskeleton dynamics. Which biological process, connected to the process supported by this evidence via an ... | regulation of cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04170","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDK5R1 is associated with multiple biological processes. One association is supported by evidence stating that Neuronal Cdc2-like kinase (Nclk) is in... | |
medium_divergent_branch_04171 | ZWINT is associated with multiple biological processes. One association is supported by evidence that ZWINT-suppressed cells exhibit a chromosome bridge phenotype with interconnected sister chromatids. Which biological process, connected to the process supported by this evidence via a 'part of' relationship, is the tar... | mitotic nuclear division | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04171","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZWINT is associated with multiple biological processes. One association is supported by evidence that ZWINT-suppressed cells exhibit a chromosome bri... | |
medium_divergent_branch_04172 | RAD17 interacts with multiple proteins. One interaction is supported by evidence stating that 'The human Rad17-Rfc2-5 and Rad9-Rad1-Hus1 complexes play crucial roles in the activation of the ATR-mediated DNA damage and DNA replication stress response pathways.' Which protein, connected to RAD17 via this interaction, is... | Replication factor C subunit 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04172","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAD17 interacts with multiple proteins. One interaction is supported by evidence stating that 'The human Rad17-Rfc2-5 and Rad9-Rad1-Hus1 complexes pl... | |
medium_divergent_branch_04173 | NEK7 is reported to interact with multiple proteins. One specific interaction is supported by evidence stating: 'Nek6 (314AA) and Nek7 (303AA), 76% identical, have little noncatalytic sequence but bind to the carboxyl-terminal noncatalytic tail of a NIMA family protein kinase that is activated in mitosis.' Which protei... | Serine/threonine-protein kinase Nek9 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04173","source_qa_id":"medium_divergent_branch_06321","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"NEK7 is reported to interact with multiple proteins. One specific interaction is supported by evi... | |
medium_divergent_branch_04174 | PGAM1 interacts with multiple proteins. One of these interacting partners has been shown to enhance the protein stability of phosphoglycerate mutase 1 (PGAM1) via direct interaction. Which protein, connected to PGAM1 through this interaction, is the subject of this mechanistic evidence? | Ubiquitin carboxyl-terminal hydrolase 46 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04174","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PGAM1 interacts with multiple proteins. One of these interacting partners has been shown to enhance the protein stability of phosphoglycerate mutase ... | |
medium_divergent_branch_04175 | SOCS1 interacts with multiple proteins. One interaction is characterized by enhanced coprecipitation of the partner with SOCS1 and reduced SOCS1 expression due to proteasomal degradation in VHL-null renal cell carcinoma (RCC) compared with wild-type cells. Which protein is connected to SOCS1 through this specific inter... | Suppressor of cytokine signaling 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04175","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SOCS1 interacts with multiple proteins. One interaction is characterized by enhanced coprecipitation of the partner with SOCS1 and reduced SOCS1 expr... | |
medium_divergent_branch_04176 | hsa-miR-107 regulates more than one cell type. One line of evidence states: 'Lastly, treatment with an miR-107 mimic caused the decrease in the secretion of IgG and IgM antibodies from B lymphocytes of transplant recipients, indicating that deregulated miR-107 could be involved in the pathogenesis of ABMR.' Which cell ... | lymphocyte of B lineage | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04176","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"hsa-miR-107 regulates more than one cell type. One line of evidence states: 'Lastly, treatment with an miR-107 mimic caused the decrease in the secre... | |
medium_divergent_branch_04177 | Pulmonary alveolar type 1 cells are a specific subtype of a broader cell category. Evidence for this classification describes the cell as a squamous entity that is flattened and branched, covering more than 98% of the alveolar surface with thin cytoplasmic extensions (50-100 nm) to form the air-blood barrier. Which bro... | epithelial cell of lung | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04177","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Pulmonary alveolar type 1 cells are a specific subtype of a broader cell category. Evidence for this classification describes the cell as a squamous ... | |
medium_divergent_branch_04178 | KEAP1 interacts with multiple proteins. One interaction partner is maintained in the cytoplasm under unstressed conditions via its association with KEAP1. Which disease is associated with this specific interaction partner? | immunodeficiency, developmental delay, and hypohomocysteinemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04178","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KEAP1 interacts with multiple proteins. One interaction partner is maintained in the cytoplasm under unstressed conditions via its association with K... | |
medium_divergent_branch_04179 | MYOD1 interacts with multiple proteins. One specific interaction is supported by evidence stating that a specific protein directly interacts with MyoD to enhance the expression of muscle differentiation genes. Which protein product is encoded by the gene corresponding to this interacting partner? | Histone-lysine N-methyltransferase SETD7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04179","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MYOD1 interacts with multiple proteins. One specific interaction is supported by evidence stating that a specific protein directly interacts with Myo... | |
medium_divergent_branch_04180 | DTX4 interacts with multiple genes. One specific interaction involves a partner protein that is recruited by NLRP4 to DTX4 for Lys48 (K48)-linked polyubiquitination at Lys670, resulting in the degradation of that partner. Which disease is associated with this specific partner gene via a biomarker relationship? | myelofibrosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04180","source_qa_id":"medium_divergent_branch_04199","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"DTX4 interacts with multiple genes. One specific interaction involves a partner protein that is r... | |
medium_divergent_branch_04181 | KMT2A interacts with multiple genes. One interaction is supported by evidence stating: 'Consistent with earlier purifications of ENL and AF4 from 293 cells, the 90 amino acid C-terminal domain of the gene interacting with KMT2A associates with many other MLL translocation partners including Enl, Af4, Laf4, Af5q31, Ell,... | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04181","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KMT2A interacts with multiple genes. One interaction is supported by evidence stating: 'Consistent with earlier purifications of ENL and AF4 from 293... | |
medium_divergent_branch_04182 | The gene GNB2 interacts with multiple partners. One specific interaction is supported by evidence stating: 'The data show that PhLP1 plays a vital role in the assembly of Ggamma2 with all four Gbeta1-4 subunits and in the assembly of Gbeta2 with all twelve Ggamma subunits, without affecting the specificity of the Gbeta... | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04182","source_qa_id":"medium_divergent_branch_05714","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene GNB2 interacts with multiple partners. One specific interaction is supported by evidence... | |
medium_divergent_branch_04183 | The primitive nephron is a type of two different anatomical structures. One of these structures is defined as an epithelial tube that is fated to become a nephron. Which anatomical structure is the primitive nephron a part of, given that it belongs to the structure defined by this fate? | kidney | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04183","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The primitive nephron is a type of two different anatomical structures. One of these structures is defined as an epithelial tube that is fated to bec... | |
medium_divergent_branch_04184 | CUL7 interacts with multiple proteins. One interaction is supported by evidence stating: 'Remarkably, CUL7 assembles an SCF-ROC1-like E3 ubiquitin ligase complex consisting of Skp1, CUL7, the F-box protein encoded by the gene FBXW8, and ROC1.' Which protein, connected to CUL7 via a binding interaction, is described in ... | F-box/WD repeat-containing protein 8 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04184","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CUL7 interacts with multiple proteins. One interaction is supported by evidence stating: 'Remarkably, CUL7 assembles an SCF-ROC1-like E3 ubiquitin li... | |
medium_divergent_branch_04185 | CD4 is associated with multiple biological processes. One association is supported by evidence stating: 'We determined that the activation of CD4 via interaction with major histocompatibility complex class II (MHC-II) triggers cytokine expression and the differentiation of human monocytes into functional mature macroph... | monocyte differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04185","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CD4 is associated with multiple biological processes. One association is supported by evidence stating: 'We determined that the activation of CD4 via... | |
medium_divergent_branch_04186 | TAB2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Through biochemical studies, we found that SIK1 and the hidden candidate interact with TGF-β-activated kinase 1-binding protein 2 (TAB2), and interrupt the functional complex of TAB2-TNF receptor-associated factor 6 (TRAF6).... | spondyloepimetaphyseal dysplasia, Krakow type | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04186","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TAB2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Through biochemical studies, we found that SIK1 and t... | |
medium_divergent_branch_04187 | PIAS3 is reported to interact with multiple genes. One specific interaction is supported by evidence stating: 'Through yeast two-hybrid screening and co-immunoprecipitation assays from eukaryotic cells, we also discovered the interaction between HMGI-C and PIAS3 (protein inhibitor of activated STAT3 (signal transducer ... | UBN1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04187","source_qa_id":"medium_divergent_branch_01073","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"PIAS3 is reported to interact with multiple genes. One specific interaction is supported by evide... | |
medium_divergent_branch_04188 | PTGES3 interacts with multiple genes. One interaction is supported by evidence stating: 'Here we report an interaction between the C-terminal catalytic domain of the MTase and p23, a protein previously reported to associate with the progesterone receptor (PR) complex.' Which protein is encoded by the gene that interact... | DNA (cytosine-5)-methyltransferase 3A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04188","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PTGES3 interacts with multiple genes. One interaction is supported by evidence stating: 'Here we report an interaction between the C-terminal catalyt... | |
medium_divergent_branch_04189 | MYO1C is associated with multiple biological processes. One association is supported by evidence showing that knockdown of MYO1C impairs the ability to form tight junctions, as measured by transepithelial electric resistance (TER) and bovine serum albumin (BSA) permeability assays. Which biological process, connected t... | regulation of cell junction assembly | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04189","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MYO1C is associated with multiple biological processes. One association is supported by evidence showing that knockdown of MYO1C impairs the ability ... |
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