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medium_divergent_branch_04190 | ICAM1 interacts with multiple genes. One of these interacting partners is characterized by experimental evidence showing that Phosphatidylinositol 4, 5-bisphosphate (PtdIns(4,5)P2) induces its interaction with ICAM-1 and enhances its interaction with ICAM-2, whereas ICAM-3 does not bind to this partner even in the pres... | triple-negative breast carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04190","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ICAM1 interacts with multiple genes. One of these interacting partners is characterized by experimental evidence showing that Phosphatidylinositol 4,... | |
medium_divergent_branch_04191 | SNAPIN interacts with multiple proteins. One interaction is characterized by association with the SNARE complex through direct binding to a specific SNARE protein. Which protein is encoded by the gene corresponding to this specific interaction partner? | Synaptosomal-associated protein 25 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04191","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SNAPIN interacts with multiple proteins. One interaction is characterized by association with the SNARE complex through direct binding to a specific ... | |
medium_divergent_branch_04192 | The stomach is classified as a type of anatomy. One classification path describes the stomach as an expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ, lined in whole or in part by a glandular epithelium. Based on this description, which anatomical category ... | digestive system element | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04192","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The stomach is classified as a type of anatomy. One classification path describes the stomach as an expanded region of the vertebrate alimentary trac... | |
medium_divergent_branch_04193 | The fibrinogen complex is structurally associated with multiple anatomical entities. One of these associations is supported by the description: 'The liquid component of blood, in which erythrocytes are suspended.' Identify the anatomical entity that matches this description and determine its broader biological classifi... | haemolymphatic fluid | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04193","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The fibrinogen complex is structurally associated with multiple anatomical entities. One of these associations is supported by the description: 'The ... | |
medium_divergent_branch_04194 | MLLT4 interacts with multiple genes. One of these interaction partners was identified as a binding protein for AF-6 in studies investigating the role of AF-6 in junctions. Which disease is associated with this specific interaction partner? | amyotrophic lateral sclerosis type 18 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04194","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MLLT4 interacts with multiple genes. One of these interaction partners was identified as a binding protein for AF-6 in studies investigating the role... | |
medium_divergent_branch_04195 | Lenvatinib interacts with multiple drugs. One interaction is supported by evidence stating: 'we tested the efficacy of two CDK4/6 inhibitors, abemaciclib and this drug, in combination with lenvatinib, a multi-kinase inhibitor approved as first-line therapy for advanced HCC, in a panel of HCC Rb-expressing cell lines.' ... | cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04195","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Lenvatinib interacts with multiple drugs. One interaction is supported by evidence stating: 'we tested the efficacy of two CDK4/6 inhibitors, abemaci... | |
medium_divergent_branch_04196 | AGO1 interacts with multiple genes. One of these interacting partners forms a complex with Argonaute proteins that is excluded from P-bodies (PBs) when the interaction with 14-3-3 proteins is disrupted, although its recruitment to stress granules (SGs) remains unaffected. Which cellular component is this specific inter... | P-body | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04196","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AGO1 interacts with multiple genes. One of these interacting partners forms a complex with Argonaute proteins that is excluded from P-bodies (PBs) wh... | |
medium_divergent_branch_04197 | CHEK1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'We identified a novel interaction between this gene and checkpoint kinase CHK1 and showed that the defective damage response in this gene-deficient cells is at least in part due to altered CHK1 subcellular localization.' Wh... | Ogden syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04197","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CHEK1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'We identified a novel interaction between this gene ... | |
medium_divergent_branch_04198 | The gene OPRD1 interacts with multiple partners. One interaction is supported by evidence stating: 'We find that co-expression of mu and delta receptors in heterologous cells followed by selective immunoprecipitation results in the isolation of mu-delta heterodimers.' Which protein is encoded by the gene that interacts... | Mu-type opioid receptor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04198","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene OPRD1 interacts with multiple partners. One interaction is supported by evidence stating: 'We find that co-expression of mu and delta recept... | |
medium_divergent_branch_04199 | CARM1 interacts with multiple genes. One of these interacting partners forms a ternary complex with CARM1 and p300/CBP in cultured mammalian cells, a finding that supports a physiological role for the observed synergy. Which disease is associated with this specific interacting gene through genomic alterations? | Fraser syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04199","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CARM1 interacts with multiple genes. One of these interacting partners forms a ternary complex with CARM1 and p300/CBP in cultured mammalian cells, a... | |
medium_divergent_branch_04200 | The placenta is described as an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. Its fetal portion is the villous chorion, and its maternal portion is the decidua basalis. These portions are held together by anchoring villi anchored to the decidua basali... | conceptus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04200","source_qa_id":"medium_divergent_branch_01617","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The placenta is described as an organ of metabolic interchange between fetus and mother, partly o... | |
medium_divergent_branch_04201 | TRPC4 is associated with multiple cellular components via the 'located in' relationship. One of these associations is supported by evidence stating that TRPC1 forms channel complexes together with TRPC4 and TRPC5. Which cellular component, connected to the selected component via an 'is a' relationship, is best supporte... | monoatomic ion channel complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04201","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRPC4 is associated with multiple cellular components via the 'located in' relationship. One of these associations is supported by evidence stating t... | |
medium_divergent_branch_04202 | EIF4E interacts with multiple proteins. One interaction is supported by evidence stating: 'The abundance of eIF4E bound to a specific translation initiation factor scaffold protein and the extent of phosphorylation of eIF4E were increased by 800 and 20%, respectively.' Which protein, connected to EIF4E via this interac... | Eukaryotic translation initiation factor 4 gamma 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04202","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EIF4E interacts with multiple proteins. One interaction is supported by evidence stating: 'The abundance of eIF4E bound to a specific translation ini... | |
medium_divergent_branch_04203 | Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.269 and an adjusted p-value of 0.0484. For which disease is that selected gene recorded as a biomarker? | major depressive disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04203","source_qa_id":"medium_divergent_branch_05905","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showe... | |
medium_divergent_branch_04204 | NUP98 interacts with multiple proteins. One interaction partner is described in evidence stating that a specific export factor interacts with multiple components of the nuclear pore complex (NPC), including the nucleoporins CAN, Nup98, Nup153, and p62, as well as three major NPC subcomplexes. Which protein is encoded b... | Nuclear RNA export factor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04204","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NUP98 interacts with multiple proteins. One interaction partner is described in evidence stating that a specific export factor interacts with multipl... | |
medium_divergent_branch_04205 | ASCL1 interacts with multiple transcription factors. One interaction is supported by evidence stating: 'We show that a specific transcription factor interacts with HASH-1 in both yeast and mammalian cells.' Which protein is encoded by the gene that interacts with ASCL1 in this specific context? | Transcription factor 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04205","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ASCL1 interacts with multiple transcription factors. One interaction is supported by evidence stating: 'We show that a specific transcription factor ... | |
medium_divergent_branch_04206 | RNF34 interacts with multiple proteins. One interaction is supported by evidence stating: 'We have isolated a family of apoptotic inhibitors [caspases-8- and -10-associated RING proteins (CARPs)] that bind to and negatively regulate DED caspases.' Which protein is encoded by the gene that interacts with RNF34 in this s... | Caspase-8 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04206","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF34 interacts with multiple proteins. One interaction is supported by evidence stating: 'We have isolated a family of apoptotic inhibitors [caspase... | |
medium_divergent_branch_04207 | MIR145 is associated with multiple biological processes. One association is supported by evidence stating that over-expression of miR-145 significantly inhibited H₂O₂-induced cellular apoptosis. Which biological process is negatively regulated by the process linked to this specific evidence? | cardiac muscle cell apoptotic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04207","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR145 is associated with multiple biological processes. One association is supported by evidence stating that over-expression of miR-145 significant... | |
medium_divergent_branch_04208 | The gene CACNA1A interacts with multiple partners. One specific interaction involves the carboxyl-terminal cytoplasmic domain of the alpha 1A subunit, which shows specificity for the beta 4 isoform (and to a lesser extent beta 2a). Which protein is encoded by the gene that binds to CACNA1A in this specific manner? | Voltage-dependent L-type calcium channel subunit beta-4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04208","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CACNA1A interacts with multiple partners. One specific interaction involves the carboxyl-terminal cytoplasmic domain of the alpha 1A subunit... | |
medium_divergent_branch_04209 | The gene DNAH7 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating: 'These studies identify DNAH7 as an inner arm component of human cilia.' Which cellular component is connected to this specific entity through the 'is a' relations... | axonemal dynein complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04209","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene DNAH7 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence s... | |
medium_divergent_branch_04210 | The protein TNP1 is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by the following evidence: 'Spermatid nuclear condensation occurs, albeit in an abnormal fashion, and the mature sperm of the Tnp -null mutants are not as condensed as wild-type sp... | spermatid development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04210","source_qa_id":"medium_divergent_branch_02986","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The protein TNP1 is associated with multiple biological processes via the 'involved in' relations... | |
medium_divergent_branch_04211 | The gene NAPA is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'Both NH2-terminal (1-160) and COOH-terminal (160-295) fragments of alpha-SNAP were able to bind to this protein, suggesting that alpha-SNAP contains distinct NH2- and COOH-terminal binding sites for th... | Vesicle-fusing ATPase | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04211","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene NAPA is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'Both NH2-terminal (1-160) and ... | |
medium_divergent_branch_04212 | CHFR interacts with multiple genes. One interaction is supported by evidence stating: 'Here we show that CHFR binds to and ubiquitinates the interaction partner, leading to its degradation.' Which cell type is enriched in the gene that corresponds to this specific interaction evidence? | plasmacytoid dendritic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04212","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CHFR interacts with multiple genes. One interaction is supported by evidence stating: 'Here we show that CHFR binds to and ubiquitinates the interact... | |
medium_divergent_branch_04213 | MIR98 is associated with multiple biological processes. One association is supported by evidence showing that reducing miR-98 expression increases the osteogenic differentiation ability of human bone marrow stromal cells (hBMSCs), an effect that is diminished by siBMP2 transfection. Which biological process is negative... | osteoblast differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04213","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR98 is associated with multiple biological processes. One association is supported by evidence showing that reducing miR-98 expression increases th... | |
medium_divergent_branch_04214 | FRS2 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Importantly, we demonstrate that the phosphotyrosine binding domain of FRS-2 directly binds the Trk receptors at the same phosphotyrosine residue that binds the signaling adapter Shc.' Which disease is connected to the gene... | congenital mesoblastic nephroma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04214","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FRS2 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Importantly, we demonstrate that the phosphotyrosine... | |
medium_divergent_branch_04216 | ELK4 interacts with multiple proteins. One interaction is supported by evidence stating: 'We report that Dok-4 interacts with the transactivation domain of Elk-4 through an atypical phosphotyrosine-binding domain-mediated interaction.' Which protein product is encoded by the gene corresponding to this interacting partn... | Docking protein 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04216","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ELK4 interacts with multiple proteins. One interaction is supported by evidence stating: 'We report that Dok-4 interacts with the transactivation dom... | |
medium_divergent_branch_04217 | Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.693 and an adjusted p-value of 0.0381. For which disease is that selected gene recorded as a biomarker? | depressive disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04217","source_qa_id":"medium_divergent_branch_06961","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch sho... | |
medium_divergent_branch_04218 | ARF6 interacts with multiple proteins. One specific interaction is described by the statement: 'Here, we report that both FIP3 and FIP4 bind ARF6 in a nucleotide-dependent manner but exhibit differential affinities for Rab11 and ARF6.' Based on this description, identify the protein referred to as FIP3 that binds ARF6,... | spina bifida cystica | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04218","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARF6 interacts with multiple proteins. One specific interaction is described by the statement: 'Here, we report that both FIP3 and FIP4 bind ARF6 in ... | |
medium_divergent_branch_04219 | RYBP interacts with multiple proteins. One interaction is supported by evidence stating: 'Reflecting this similarity, both YAF-2 and this novel protein (named YEAF1 for YY1- and E4TF1/hGABP-associated factor-1) interacted with hGABP beta and YY1 in vitro and in vivo, indicating that YEAF1 and YAF-2 constitute a cofacto... | GA-binding protein subunit beta-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04219","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RYBP interacts with multiple proteins. One interaction is supported by evidence stating: 'Reflecting this similarity, both YAF-2 and this novel prote... | |
medium_divergent_branch_04220 | PTGES3 interacts with multiple genes. One of these interactions is supported by evidence stating: 'In this report we show that the heat shock protein 90 (HSP90) co-chaperones p23 and FKBP38 interact via a conserved Pro-Xaa-Leu-Glu motif (where Xaa = any amino acid) in these proteins with the N-terminal Myeloid Nervy an... | pulmonary edema | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04220","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PTGES3 interacts with multiple genes. One of these interactions is supported by evidence stating: 'In this report we show that the heat shock protein... | |
medium_divergent_branch_04221 | The gene C3 is associated with multiple proteins via binding interactions. One specific interaction is supported by evidence stating: 'Similarly, direct C3(NH3)-factor I and C3(NH3)-factor H binding was characterized [where C3(NH3) is a form of C3 that is cleaved by factor I in the presence of factor H].' Which protein... | Complement factor I | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04221","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene C3 is associated with multiple proteins via binding interactions. One specific interaction is supported by evidence stating: 'Similarly, dir... | |
medium_divergent_branch_04222 | The gene SLF2 is associated with multiple interacting partners. One specific interaction involves a protein whose coiled-coil arm binds to hNSE6 and hNSE5, a process mediated by a conserved FAM178 domain renamed CANIN (Coiled-coil [Protein Name] And NSE5 INteracting). Which protein is encoded by the gene connected to S... | Structural maintenance of chromosomes protein 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04222","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene SLF2 is associated with multiple interacting partners. One specific interaction involves a protein whose coiled-coil arm binds to hNSE6 and ... | |
medium_divergent_branch_04223 | COL17A1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The interaction of BPAG2/K18 was confirmed by an in vitro protein-protein interaction assay, which also confirmed that normal human keratinocytes express K18 in culture.' Which protein, among those interacting with COL... | Keratin, type I cytoskeletal 18 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04223","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"COL17A1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The interaction of BPAG2/K18 was confirmed by a... | |
medium_divergent_branch_04224 | DIS3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we demonstrate the association of two different Dis3p homologs--hDIS3 and hDIS3L--with the human exosome core.' Which protein, connected to DIS3 via a binding interaction, is described by this evidence? Provide the protein e... | Exosome complex component RRP4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04224","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DIS3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we demonstrate the association of two different Dis3p... | |
medium_divergent_branch_04226 | TRPC1 interacts with multiple proteins. One interaction involves an adaptor protein termed Homer, which facilitates a physical association between TRPC1 and the IP(3) receptor, a connection required for the TRP channel to respond to signals. Which protein is encoded by the gene that interacts with TRPC1 in this specifi... | Homer protein homolog 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04226","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRPC1 interacts with multiple proteins. One interaction involves an adaptor protein termed Homer, which facilitates a physical association between TR... | |
medium_divergent_branch_04227 | TRIM27 interacts with multiple genes. One of these interaction partners is described in the literature as a target of TRIM27, which acts as a novel E3 ubiquitin ligase inducing K27/48-linked ubiquitination of the unpalmitoylated form of this partner at Lys278. Which disease is associated with this specific interaction ... | gonorrhea | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04227","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM27 interacts with multiple genes. One of these interaction partners is described in the literature as a target of TRIM27, which acts as a novel E... | |
medium_divergent_branch_04228 | EEF1B2 interacts with multiple genes. One interaction partner is described by evidence stating: 'Human [interaction partner] interacts with the metazoan-specific eukaryotic elongation factor 1Bδ (eEF1Bδ) and inhibits its guanine nucleotide exchange factor (GEF) activity, but the structural mechanism remains unknown.' W... | dental caries | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04228","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EEF1B2 interacts with multiple genes. One interaction partner is described by evidence stating: 'Human [interaction partner] interacts with the metaz... | |
medium_divergent_branch_04230 | RAB27A is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating: 'We also show that melanophilin associates with RAB27A and myosin Va on melanosomes in melanocytes.' Based on this evidence, which cellular component is the correct target... | melanocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04230","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAB27A is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating: ... | |
medium_divergent_branch_04232 | IRGM is associated with multiple biological processes. One association is supported by evidence stating: 'Here, we found that IRGM is a master negative regulator of the interferon response.' Which biological process, connected to the process supported by this evidence via a 'negatively regulates' relationship, is the t... | type I interferon production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04232","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IRGM is associated with multiple biological processes. One association is supported by evidence stating: 'Here, we found that IRGM is a master negati... | |
medium_divergent_branch_04233 | FGFR3 is associated with multiple biological processes. One of these processes is supported by evidence stating that conventional knockout of the gene's alleles leads to a short life span and overgrowth of bone. Which broader biological category is this specific process a subclass of? | animal organ morphogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04233","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FGFR3 is associated with multiple biological processes. One of these processes is supported by evidence stating that conventional knockout of the gen... | |
medium_divergent_branch_04234 | The gene F11R is reported to interact with multiple partners. One specific interaction is supported by evidence stating: 'Finally, we observed that protein interacting with C-kinase-1 (PICK-1) also interacts directly with the junctional adhesion molecules, and we suggest that PICK-1 could be involved in the regulation ... | PRKCA-binding protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04234","source_qa_id":"medium_divergent_branch_01172","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene F11R is reported to interact with multiple partners. One specific interaction is support... | |
medium_divergent_branch_04235 | KCNE5 is associated with multiple biological processes. One association is supported by evidence that transient transfection of Chinese hamster ovary (CHO) cells expressing IKs (KCNQ1+KCNE1) with KCNE5 suppressed the developing and tail currents of IKs in a concentration-dependent manner. Which biological process, conn... | atrial cardiac muscle cell membrane repolarization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04235","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KCNE5 is associated with multiple biological processes. One association is supported by evidence that transient transfection of Chinese hamster ovary... | |
medium_divergent_branch_04236 | NSD1 interacts with multiple proteins. One specific interaction partner is described as a novel protein containing a SCAN box, a KRAB-A domain, and four consensus C2H2-type zinc fingers preceded by a unique finger derivative referred to as the C2HR motif. Which protein corresponds to this description? | Zinc finger protein 496 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04236","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NSD1 interacts with multiple proteins. One specific interaction partner is described as a novel protein containing a SCAN box, a KRAB-A domain, and f... | |
medium_divergent_branch_04237 | AMFR interacts with multiple genes. One of these interaction partners is characterized by evidence stating that glycosylation of this protein interferes with its interaction and ubiquitination by this entity, leading to its stabilization. Which disease is associated with this specific gene through genomic alterations? | rheumatoid arthritis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04237","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AMFR interacts with multiple genes. One of these interaction partners is characterized by evidence stating that glycosylation of this protein interfe... | |
medium_divergent_branch_04238 | GNAS interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We identified a protein member of the synembryn family as one of the interacting proteins.' Which biological process is the gene corresponding to this specific interacting protein involved in? | regulation of G protein-coupled receptor signaling pathway | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04238","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GNAS interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We identified a protein member of the synembryn fa... | |
medium_divergent_branch_04239 | STRN4 interacts with multiple proteins. One interaction is supported by evidence describing the STRIPAK complex, which contains the PP2A catalytic subunit and scaffolding (PP2A A) subunits, the striatins (PP2A regulatory B''' subunits), the striatin-associated protein Mob3, the novel proteins STRIP1 and STRIP2 (formerl... | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04239","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"STRN4 interacts with multiple proteins. One interaction is supported by evidence describing the STRIPAK complex, which contains the PP2A catalytic su... | |
medium_divergent_branch_04241 | BAZ1A interacts with multiple genes. One of these interaction partners is supported by evidence stating that CHRAC-17 interacts with another histone-fold protein, p12, in DNA polymerase epsilon, whereas CHRAC-15 is essential for interaction with ACF and enhancement of nucleosome sliding. Which protein is encoded by the... | DNA polymerase epsilon subunit 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04241","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BAZ1A interacts with multiple genes. One of these interaction partners is supported by evidence stating that CHRAC-17 interacts with another histone-... | |
medium_divergent_branch_04242 | KLHL2 interacts with multiple genes. One of these interaction partners is supported by evidence stating: 'We found that KLHL2, as well as KLHL3, was co-immunoprecipitated with all four WNK isoforms.' Which disease is connected to this specific interacting gene through genomic alterations? | thyroid gland papillary carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04242","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KLHL2 interacts with multiple genes. One of these interaction partners is supported by evidence stating: 'We found that KLHL2, as well as KLHL3, was ... | |
medium_divergent_branch_04243 | RNF13 interacts with multiple proteins. One of these interaction partners is characterized by evidence stating that 'GST-pulldown and co-immunoprecipitation show that RNF13 variants disrupt association with AP-3 complex.' What is the protein product encoded by this interaction partner? | AP-3 complex subunit delta-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04243","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF13 interacts with multiple proteins. One of these interaction partners is characterized by evidence stating that 'GST-pulldown and co-immunoprecip... | |
medium_divergent_branch_04244 | MED8 interacts with multiple genes. One interaction is supported by evidence stating: 'In this report we demonstrate (i) that mammalian MED8 is a subunit of the mammalian Mediator complex and (ii) that MED8 can assemble with Elongins B and C, Cul2, and Rbx1 to reconstitute a ubiquitin ligase.' Which disease is associat... | renal cell carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04244","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MED8 interacts with multiple genes. One interaction is supported by evidence stating: 'In this report we demonstrate (i) that mammalian MED8 is a sub... | |
medium_divergent_branch_04245 | The NIPBL gene is associated with multiple biological processes. One association is supported by evidence stating: 'We identified mutations in one gene in this region, which we named NIPBL, in four sporadic and two familial cases of CdLS.' Based on this specific evidence, which biological process is NIPBL involved in, ... | growth | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04245","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The NIPBL gene is associated with multiple biological processes. One association is supported by evidence stating: 'We identified mutations in one ge... | |
medium_divergent_branch_04246 | MAP1B is associated with multiple biological processes. One association is supported by the statement: 'On the basis of these data, MAP-1B could be considered as a new protein involved in the terminal differentiation of odontoblasts.' Identify the biological process described by this evidence, and then determine the pa... | neuroepithelial cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04246","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP1B is associated with multiple biological processes. One association is supported by the statement: 'On the basis of these data, MAP-1B could be c... | |
medium_divergent_branch_04247 | The gene PTHLH is associated with multiple proteins via binding interactions. One specific interaction is supported by evidence stating that Parathyroid hormone (PTH) and PTH-related protein (PTHrP) are calciotropic hormones that interact with a shared seven-transmembrane domain G protein-coupled receptor, predominantl... | Parathyroid hormone/parathyroid hormone-related peptide receptor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04247","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PTHLH is associated with multiple proteins via binding interactions. One specific interaction is supported by evidence stating that Parathyr... | |
medium_divergent_branch_04248 | HOOK2 interacts with multiple genes. One of these interactions is supported by evidence stating that 'Hook proteins were found to form homo- and heterodimers.' Which gene, connected to HOOK2 via an interaction, is the subject of this specific evidence? | CTIF | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04248","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HOOK2 interacts with multiple genes. One of these interactions is supported by evidence stating that 'Hook proteins were found to form homo- and hete... | |
medium_divergent_branch_04249 | The gene PDLIM1 is enriched in multiple cell types. One specific cell type shows a mean expression of 181.08 TPM, a z-score of 1.77, and a fold enrichment of 6.41. Which broader cell lineage category is this specific cell type a subtype of? | mature B cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04249","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PDLIM1 is enriched in multiple cell types. One specific cell type shows a mean expression of 181.08 TPM, a z-score of 1.77, and a fold enric... | |
medium_divergent_branch_04250 | PLK1 is associated with multiple biological processes. One association is supported by evidence stating: 'We identified the protein kinase Plk1 as a potential target of CYLD in the regulation of mitotic entry, based on their physical interaction and similar loss-of-function and overexpression phenotypes.' Which biologi... | mitotic cell cycle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04250","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PLK1 is associated with multiple biological processes. One association is supported by evidence stating: 'We identified the protein kinase Plk1 as a ... | |
medium_divergent_branch_04251 | HDAC2 is implicated in multiple biological processes. One specific connection is supported by evidence stating: 'We find that deletion of ectodermal Hdac1 and Hdac2 results in dramatic failure of hair follicle specification and epidermal proliferation and stratification, phenocopying loss of the key ectodermal transcri... | epidermis development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04251","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HDAC2 is implicated in multiple biological processes. One specific connection is supported by evidence stating: 'We find that deletion of ectodermal ... | |
medium_divergent_branch_04252 | RBM45 interacts with multiple proteins. One of these interaction partners is notable because it, along with other ALS-linked RNA-binding proteins such as FUS, Matrin-3, and hnRNP-A1, is found within intracellular inclusions in ALS/FTLD. Which protein is encoded by the gene corresponding to this specific interaction par... | TAR DNA-binding protein 43 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04252","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RBM45 interacts with multiple proteins. One of these interaction partners is notable because it, along with other ALS-linked RNA-binding proteins suc... | |
medium_divergent_branch_04253 | TEAD4 interacts with multiple proteins. One specific interaction is supported by evidence stating that the interaction between IRF2BP2 and VGLL4 increased the binding of TEAD4 to this protein, resulting in the transcriptional coactivation of CTGF. Which protein is this? | Transcriptional coactivator YAP1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04253","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TEAD4 interacts with multiple proteins. One specific interaction is supported by evidence stating that the interaction between IRF2BP2 and VGLL4 incr... | |
medium_divergent_branch_04255 | IL17F is associated with multiple biological processes. One association is supported by evidence stating: 'We report a novel human IL-17 homolog, IL-17F, and show that it is expressed by activated T cells, can stimulate production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can ... | regulation of cytokine production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04255","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IL17F is associated with multiple biological processes. One association is supported by evidence stating: 'We report a novel human IL-17 homolog, IL-... | |
medium_divergent_branch_04256 | NELFB interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we show that the killer fragment of a neurotrophic receptor tyrosine kinase interacts with Cobra1, a putative cofactor of BRCA1, and that Cobra1 is required for the receptor-induced apoptosis.' Which disease is associated with... | Hirschsprung disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04256","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NELFB interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we show that the killer fragment of a neurotrophic rece... | |
medium_divergent_branch_04258 | ATF5 interacts with multiple genes. One specific interaction is supported by evidence stating: 'The interaction was confirmed by in vivo coimmunoprecipitation and in vitro binding analysis.' Which cellular component is the gene involved in this specific interaction located in? | cyclin-dependent protein kinase holoenzyme complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04258","source_qa_id":"medium_divergent_branch_05826","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ATF5 interacts with multiple genes. One specific interaction is supported by evidence stating: 'T... | |
medium_divergent_branch_04259 | VASP interacts with multiple proteins. One interaction partner is described in a study stating: 'In contrast, phosphorylation had no significant effect on VASP oligomerization or its interaction with its known ligands profilin, vinculin, and [this protein].' Which protein is this interaction partner? | Zyxin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04259","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VASP interacts with multiple proteins. One interaction partner is described in a study stating: 'In contrast, phosphorylation had no significant effe... | |
medium_divergent_branch_04261 | DLG1 interacts with multiple proteins. One specific interaction involves hDlg and p56lck, where direct binding was demonstrated using glutathione S-transferase fusion proteins of hDlg and recombinant p56lck expressed in baculovirus-infected Sf9 cells. Which protein is encoded by the gene that interacts with DLG1 in thi... | Tyrosine-protein kinase Lck | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04261","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DLG1 interacts with multiple proteins. One specific interaction involves hDlg and p56lck, where direct binding was demonstrated using glutathione S-t... | |
medium_divergent_branch_04262 | Phospholipase D1 (PLD1) is associated with multiple cellular components. One association is supported by evidence that the K898R mutant of PLD1 blocks acetylcholine release by reducing the number of active presynaptic-releasing sites. Which cellular component, connected to the component implicated by this evidence via ... | synapse | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04262","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Phospholipase D1 (PLD1) is associated with multiple cellular components. One association is supported by evidence that the K898R mutant of PLD1 block... | |
medium_divergent_branch_04263 | SPRED2 interacts with multiple proteins. One interaction partner is described as a highly conserved multidomain protein that interacts and colocalizes with SPRED2 in vivo, and is referred to as 'Neighbor of BRCA1'. Which protein is encoded by the gene corresponding to this interaction partner? | Next to BRCA1 gene 1 protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04263","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SPRED2 interacts with multiple proteins. One interaction partner is described as a highly conserved multidomain protein that interacts and colocalize... | |
medium_divergent_branch_04264 | Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.157 and an adjusted p-value of 0.0459. For which disease is that selected gene recorded as a biomarker? | myotonic dystrophy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04264","source_qa_id":"medium_divergent_branch_03898","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch sho... | |
medium_divergent_branch_04265 | The gene RPL4 interacts with multiple proteins. One specific interaction is characterized by the binding of the partner protein to RPL4, which reduces the interaction between RPL4 and MDM2. Which protein is encoded by the gene corresponding to this specific interacting partner? | Peroxiredoxin-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04265","source_qa_id":"medium_divergent_branch_05385","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene RPL4 interacts with multiple proteins. One specific interaction is characterized by the ... | |
medium_divergent_branch_04266 | UHRF1 interacts with multiple genes. One interaction is supported by evidence stating: 'Combinatorial recognition of H3K9me3-containing histone H3 tail by the PHD finger and double Tudor domain may play a role in establishing and maintaining histone H3K9 methylation patterns during the cell cycle.' Which disease is ass... | mammary neoplasms, animal | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04266","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UHRF1 interacts with multiple genes. One interaction is supported by evidence stating: 'Combinatorial recognition of H3K9me3-containing histone H3 ta... | |
medium_divergent_branch_04267 | Factor X (F10) interacts with multiple genes. One interaction is supported by evidence stating: 'Nondenaturing PAGE, however, showed that a specific inhibitor bound to Xa but not to X or Xa inactivated by diisopropyl fluorophosphate.' Which disease is therapeutically linked to the gene identified by this specific evide... | myocardial infarction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04267","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Factor X (F10) interacts with multiple genes. One interaction is supported by evidence stating: 'Nondenaturing PAGE, however, showed that a specific ... | |
medium_divergent_branch_04268 | PTPN18 interacts with multiple genes. One specific interaction is characterized by the binding of PTP HSCF to a proline-rich protein tyrosine phosphatase-interacting protein, which is induced by a novel interaction between the putative coiled-coil region of this protein and the COOH-terminal, proline-rich region of the... | hyperzincemia with functional zinc depletion | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04268","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PTPN18 interacts with multiple genes. One specific interaction is characterized by the binding of PTP HSCF to a proline-rich protein tyrosine phospha... | |
medium_divergent_branch_04269 | Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -2.342 and an adjusted p-value of 0.0477. For which disease is that selected gene recorded as a biomarker? | hearing loss disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04269","source_qa_id":"medium_divergent_branch_00591","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch sho... | |
medium_divergent_branch_04270 | GABARAPL1 interacts with multiple proteins. One specific interaction partner was identified in a study using GST pull-down, mass spectrometry, and coimmunoprecipitation experiments, where the partner was described as a heat shock protein 90 family member. Which cell type is enriched for this specific interaction partne... | natural killer cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04270","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GABARAPL1 interacts with multiple proteins. One specific interaction partner was identified in a study using GST pull-down, mass spectrometry, and co... | |
medium_divergent_branch_04271 | RXRA interacts with multiple genes. One interaction is supported by evidence stating that RXR alpha efficiently interacts with a specific transcription intermediary factor, but not with mSUG1. Which protein is encoded by the gene corresponding to this specific interaction? | Transcription intermediary factor 1-alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04271","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RXRA interacts with multiple genes. One interaction is supported by evidence stating that RXR alpha efficiently interacts with a specific transcripti... | |
medium_divergent_branch_04272 | KEAP1 interacts with multiple proteins. One interaction partner is maintained in the cytoplasm in unstressed cells via association with KEAP1. Which protein is encoded by the gene corresponding to this interaction partner? | Nuclear factor erythroid 2-related factor 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04272","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KEAP1 interacts with multiple proteins. One interaction partner is maintained in the cytoplasm in unstressed cells via association with KEAP1. Which ... | |
medium_divergent_branch_04273 | SKP1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'A protein associates with Skp-1 and is required for degradation of the cdk1 inhibitory tyrosine kinase wee1'. Which cellular component is the gene described in this evidence located in? | adherens junction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04273","source_qa_id":"medium_divergent_branch_06368","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"SKP1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'A... | |
medium_divergent_branch_04274 | FGF23 is associated with multiple biological processes. One association is supported by evidence stating: 'Here we show that both wild-type FGF-23 and the ADHR mutant, FGF-23(R179Q), inhibit phosphate uptake in renal epithelial cells.' Which biological process, connected to the process supported by this evidence via an... | regulation of transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04274","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FGF23 is associated with multiple biological processes. One association is supported by evidence stating: 'Here we show that both wild-type FGF-23 an... | |
medium_divergent_branch_04275 | DIABLO interacts with multiple genes. One interaction is characterized by evidence stating that a mutation in the Livin BIR domain greatly enhances its instability and nullifies its binding to Smac/DIABLO, resulting in reduced antiapoptosis inhibition. Which disease is associated with the gene described by this specifi... | acute leukemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04275","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DIABLO interacts with multiple genes. One interaction is characterized by evidence stating that a mutation in the Livin BIR domain greatly enhances i... | |
medium_divergent_branch_04276 | ABCA3 is associated with multiple cellular components via 'located in' relationships. One association is supported by evidence showing decreased dipalmitoyl-phosphatidylcholine (PC 32:0) content and malformed lamellar bodies in cells transfected with the K1388N variant compared to controls. Which cellular component is ... | secretory granule | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04276","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ABCA3 is associated with multiple cellular components via 'located in' relationships. One association is supported by evidence showing decreased dipa... | |
medium_divergent_branch_04278 | CASP9 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that X-linked IAP mediates the polyubiquitination of caspase-9 and Smac.' Which protein product is encoded by the gene corresponding to this interaction partner? | E3 ubiquitin-protein ligase XIAP | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04278","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CASP9 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that X-linked IAP mediates the polyubiquitina... | |
medium_divergent_branch_04279 | RTCB interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we identify the deubiquitinase [protein] as a central coordinator that interacts and co-localizes with RTCB and DDX1.' Which protein is encoded by the gene corresponding to this interacting partner? | Ubiquitin carboxyl-terminal hydrolase 45 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04279","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RTCB interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we identify the deubiquitinase [protein] as a central... | |
medium_divergent_branch_04281 | FANCC is reported to interact with multiple genes. One specific interaction involves a partner described as a 'pro-apoptotic dependence receptor'. Which gene is linked to this specific partner by the relation 'binds'? | ADGRL3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04281","source_qa_id":"medium_divergent_branch_05370","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"FANCC is reported to interact with multiple genes. One specific interaction involves a partner de... | |
medium_divergent_branch_04282 | VCAM1 is associated with multiple biological processes. One specific association is supported by evidence stating that the VCAM1/VLA4 interaction mediates both adhesion and signal transduction. Which broader biological category, defined by an 'is a' relationship, does this specific process belong to? | cell-cell adhesion | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04282","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VCAM1 is associated with multiple biological processes. One specific association is supported by evidence stating that the VCAM1/VLA4 interaction med... | |
medium_divergent_branch_04283 | The FANCC protein interacts with multiple partners. One specific interaction is supported by evidence stating: 'Here we report that FAC binds to NADPH cytochrome-P450 reductase (RED), a microsomal membrane protein involved in electron transfer, in both transfected COS-1 and normal murine liver cells.' Which disease is ... | end stage renal failure | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04283","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The FANCC protein interacts with multiple partners. One specific interaction is supported by evidence stating: 'Here we report that FAC binds to NADP... | |
medium_divergent_branch_04284 | ORAI1 is associated with multiple biological processes. One association is supported by evidence stating that Ca2+ entry via Orai1 store-operated Ca2+ channels in the plasma membrane is critical to cell function, and that Orai1 loss causes severe immunodeficiency and developmental defects. Which biological process, con... | intracellular signaling cassette | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04284","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ORAI1 is associated with multiple biological processes. One association is supported by evidence stating that Ca2+ entry via Orai1 store-operated Ca2... | |
medium_divergent_branch_04285 | HNRNPA2B1 is associated with multiple cellular components via the 'located in' relationship. One of these associations is supported by evidence stating that HNRNPA2B1 within exosomes undergoes sumoylation. Which cellular component, connected to the specific component identified by this evidence through an 'is a' relati... | extracellular vesicle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04285","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HNRNPA2B1 is associated with multiple cellular components via the 'located in' relationship. One of these associations is supported by evidence stati... | |
medium_divergent_branch_04286 | The gene FANCI is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 11.70 TPM, a z-score of 1.73, and a fold enrichment of 2.46. Which cell type corresponds to this specific expression profile, and what is its immediate parent category in the cell type... | mature T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04286","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene FANCI is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 11.70 TPM, a ... | |
medium_divergent_branch_04287 | SMAD3 interacts with multiple proteins. One interaction involves a partner that, along with TFEB and Max, associates with SMAD3 (and SMAD4) in the absence of DNA and at the PE2.1 element of the PAI-1 promoter. Which protein is this partner, and what protein product does the gene encoding this partner produce? | Transcription factor E3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04287","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMAD3 interacts with multiple proteins. One interaction involves a partner that, along with TFEB and Max, associates with SMAD3 (and SMAD4) in the ab... | |
medium_divergent_branch_04289 | PRKCB interacts with multiple proteins. One interaction is supported by evidence that B cell antigen receptor (BCR) engagement leads to the recruitment of a specific protein into lipid rafts and its subsequent association with and phosphorylation by PKCbeta. Which protein, encoded by the gene involved in this specific ... | Caspase recruitment domain-containing protein 11 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04289","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRKCB interacts with multiple proteins. One interaction is supported by evidence that B cell antigen receptor (BCR) engagement leads to the recruitme... | |
medium_divergent_branch_04290 | CCNE1 interacts with multiple proteins. One interaction partner is described as 'The major cyclin E-associated kinase in human cells'. Which protein is encoded by the gene corresponding to this kinase? | Cyclin-dependent kinase 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04290","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CCNE1 interacts with multiple proteins. One interaction partner is described as 'The major cyclin E-associated kinase in human cells'. Which protein ... | |
medium_divergent_branch_04291 | NDNF is associated with multiple biological processes. One association is supported by evidence that NDNF promoted endothelial cell network formation and survival in vitro through activation of Akt/endothelial NOS (eNOS) signaling involving integrin αvβ3. Which biological process, connected to the process described by ... | anatomical structure formation involved in morphogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04291","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NDNF is associated with multiple biological processes. One association is supported by evidence that NDNF promoted endothelial cell network formation... | |
medium_divergent_branch_04292 | CYLD interacts with multiple proteins. One specific interaction is described by the following evidence: 'Here, we show that Optineurin (Optn) dampens the antiviral innate immune response by targeting the deubiquitinating enzyme CYLD to this protein in order to inhibit its enzymatic activity.' Identify the disease assoc... | myelofibrosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04292","source_qa_id":"medium_divergent_branch_03256","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"CYLD interacts with multiple proteins. One specific interaction is described by the following evi... | |
medium_divergent_branch_04293 | WNT7B is implicated in multiple biological processes. One line of evidence notes that several Wnt proteins, including Wnt7b, are expressed in differentiating lens fiber cells. Based on this context, which biological process involving WNT7B leads to the development of lens fiber cells? | lens fiber cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04293","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WNT7B is implicated in multiple biological processes. One line of evidence notes that several Wnt proteins, including Wnt7b, are expressed in differe... | |
medium_divergent_branch_04294 | KAT7 (also known as HBO1) interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we report that histone acetyltransferase (HAT) HBO1, a MYST family protein, interacts with the p58 isoform of CDK11 in vitro and in vivo.' Based on this evidence, which protein is the interaction... | Cyclin-dependent kinase 11B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04294","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KAT7 (also known as HBO1) interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we report that histone a... | |
medium_divergent_branch_04295 | AHSA1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We identified three [chloride channel protein]-interacting proteins that are well-known heat shock protein 90 (Hsp90)-associated co-chaperones: FK506-binding protein 8 (FKBP8), activator of Hsp90 ATPase homolog 1 (Aha1), and Hsp7... | Chloride channel protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04295","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AHSA1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We identified three [chloride channel protein]-interacting... | |
medium_divergent_branch_04296 | CD24 is associated with multiple biological processes. One association is supported by evidence stating: 'we demonstrate that CD24 expression reduces SDF-1-mediated cell migration and signalling via CXCR4.' Which biological process, connected to CD24, is linked via a 'regulates' relationship to the process described in... | cytokine-mediated signaling pathway | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04296","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CD24 is associated with multiple biological processes. One association is supported by evidence stating: 'we demonstrate that CD24 expression reduces... | |
medium_divergent_branch_04297 | IL18 is associated with multiple biological processes. One specific association is supported by evidence stating that IL-23 up-regulated CD56 expression in NK-like T cells and, together with IL-18, induced proliferation of NK and NK-like T cells. Which biological process is positively regulated by the process linked to... | NK T cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04297","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IL18 is associated with multiple biological processes. One specific association is supported by evidence stating that IL-23 up-regulated CD56 express... | |
medium_divergent_branch_04298 | The protein LIGHT (encoded by TNFSF14) interacts with multiple partners. One specific interaction is described by the evidence: 'TR6 can bind to FasL and prevent FasL-induced apoptosis; it can also associate with LIGHT, another TNF family member.' Based on this description, which protein partner of LIGHT is identified?... | Tumor necrosis factor receptor superfamily member 14 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04298","source_qa_id":"medium_divergent_branch_07060","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The protein LIGHT (encoded by TNFSF14) interacts with multiple partners. One specific interaction... | |
medium_divergent_branch_04299 | RACGAP1 interacts with multiple proteins. One of these interaction partners forms a stable molecular complex with MgcRacGAP, a fact supported by glutathione S-transferase pull-down and co-immunoprecipitation experiments. Which protein is this interaction partner? | Rho-related GTP-binding protein RhoN | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04299","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RACGAP1 interacts with multiple proteins. One of these interaction partners forms a stable molecular complex with MgcRacGAP, a fact supported by glut... | |
medium_divergent_branch_04300 | CNOT1 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we show that the three human Nanos paralogs interact with the CNOT1 C-terminal domain and determine the structural basis for the specific molecular recognition.' Which gene, among those interacting with CNOT1, is described in ... | CNOT3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04300","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CNOT1 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we show that the three human Nanos paralogs interact wi... |
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