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medium_divergent_branch_04301 | Human gammaherpesvirus 4 is reported to downregulate multiple genes. One specific downregulation event is characterized by a log2 fold change of -1.665 and an adjusted p-value of 0.04607. Which disease is associated with the gene corresponding to this specific downregulation event? | glucagonoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04301","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Human gammaherpesvirus 4 is reported to downregulate multiple genes. One specific downregulation event is characterized by a log2 fold change of -1.6... | |
medium_divergent_branch_04302 | The gene TOPORS has multiple interacting partners. One of these partners is supported by evidence stating: 'In a yeast two-hybrid system, Topors interacted with both SUMO-1 and the SUMO-1 conjugating enzyme [REDACTED].' Which protein is encoded by the gene connected to TOPORS through this specific interaction? | SUMO-conjugating enzyme UBC9 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04302","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TOPORS has multiple interacting partners. One of these partners is supported by evidence stating: 'In a yeast two-hybrid system, Topors inte... | |
medium_divergent_branch_04303 | The ventral thalamic fasciculus is anatomically associated with a specific structure via a 'part of' relationship. Contextual evidence describes this fasciculus as a component of the subthalamus, sometimes synonymous with 'field H1 of Forel'. It comprises a composite bundle of cerebellothalamic (crossed) and pallidotha... | dorsal plus ventral thalamus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04303","source_qa_id":"medium_divergent_branch_04429","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The ventral thalamic fasciculus is anatomically associated with a specific structure via a 'part ... | |
medium_divergent_branch_04305 | RUNX2 interacts with multiple proteins. One interaction is supported by evidence stating: 'We show that signal transducers of transforming growth factor beta superfamily receptors, Smads, interact with RUNX2 in vivo and in vitro and enhance the transactivation ability of this factor.' Which protein, connected to RUNX2 ... | SMAD family member 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04305","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RUNX2 interacts with multiple proteins. One interaction is supported by evidence stating: 'We show that signal transducers of transforming growth fac... | |
medium_divergent_branch_04306 | HRAS is known to bind to multiple gene products. One specific interaction involves a partner that binds exclusively to the GTP-bound form of Ha-Ras, but not the GDP-bound form. Which gene product, connected to HRAS via a binding interaction, is the one described by this specificity? Identify the gene that this specific... | RAP1B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04306","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HRAS is known to bind to multiple gene products. One specific interaction involves a partner that binds exclusively to the GTP-bound form of Ha-Ras, ... | |
medium_divergent_branch_04307 | EIF4A1 interacts with multiple proteins. One of these interaction partners was confirmed via anti-tag immunoprecipitation to associate with a specific set of stress granule components, including PABPC1, YBX1, KHSRP, SYNCRIP, DDX39, ELAV1, EIF4A1, and EIF3F. Which protein, among the interactors of EIF4A1, is encoded by ... | Protein maelstrom homolog | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04307","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EIF4A1 interacts with multiple proteins. One of these interaction partners was confirmed via anti-tag immunoprecipitation to associate with a specifi... | |
medium_divergent_branch_04308 | The aortic sac is described as a dilated structure lined by endothelial cells, located at the arterial pole of the heart just above the truncus arteriosus in mammalian embryos. It serves as the primordial vascular channel from which the aortic arches arise and is homologous to the ventral aorta of gill-bearing vertebra... | heart vasculature | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04308","source_qa_id":"medium_divergent_branch_00981","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The aortic sac is described as a dilated structure lined by endothelial cells, located at the art... | |
medium_divergent_branch_04309 | PTK2B interacts with multiple proteins. One specific interaction is described by the following evidence: 'We report that Pyk2 and the interaction partner form a signaling complex that is translocated to lipid rafts and is enriched in growth cones of differentiating PC12 cells following growth factor stimulation.' What ... | E3 ubiquitin-protein ligase CBL | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04309","source_qa_id":"medium_divergent_branch_07425","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"PTK2B interacts with multiple proteins. One specific interaction is described by the following ev... | |
medium_divergent_branch_04310 | The cleidooccipital muscle is anatomically connected to more than one structure. One of these connections involves a muscle organ that attaches to the clavicle and to a specific bone. Which structure is connected to this specific bone through the 'develops from' relationship? | sclerotome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04310","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The cleidooccipital muscle is anatomically connected to more than one structure. One of these connections involves a muscle organ that attaches to th... | |
medium_divergent_branch_04311 | SAP130 interacts with multiple proteins. One of these interaction partners is characterized by having a repression domain at its C-terminus that interacts with the mSin3A-HDAC complex, and an N-terminal domain that likely mediates interaction with a transcriptional activator. Which protein, connected to SAP130 via a bi... | Paired amphipathic helix protein Sin3a | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04311","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SAP130 interacts with multiple proteins. One of these interaction partners is characterized by having a repression domain at its C-terminus that inte... | |
medium_divergent_branch_04312 | The SCN5A gene encodes the human cardiac sodium channel Na(v)1.5, which plays a critical role in cardiac excitability and the propagation of action potentials. This evidence supports a specific molecular function enabled by SCN5A. Which biological process is this specific molecular function a part of? | membrane depolarization during cardiac muscle cell action potential | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04312","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The SCN5A gene encodes the human cardiac sodium channel Na(v)1.5, which plays a critical role in cardiac excitability and the propagation of action p... | |
medium_divergent_branch_04313 | The tarsus cartilage element is a subclass of two distinct anatomical entities. One of these entities is defined as a cartilaginous condensation with the potential to develop into a tarsal bone. Which anatomical structure is the parent of this specific entity via the 'part of' relationship? | tarsal skeleton | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04313","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The tarsus cartilage element is a subclass of two distinct anatomical entities. One of these entities is defined as a cartilaginous condensation with... | |
medium_divergent_branch_04314 | PIAS3 interacts with multiple genes. One interaction is supported by evidence stating: 'We show that a RING-finger protein binds with PIAS (protein inhibitor of activated STAT) proteins, PIAS1, PIAS3, PIASxalpha and PIASy at their carboxyl-terminal region and is covalently modified by SUMO-1 (sumoylation).' Which cell ... | mucosal-associated invariant T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04314","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PIAS3 interacts with multiple genes. One interaction is supported by evidence stating: 'We show that a RING-finger protein binds with PIAS (protein i... | |
medium_divergent_branch_04315 | SAFB interacts with multiple genes. One interaction is supported by evidence stating: 'Instead, SAFB1RD was found to interact with TAFII68, a member of the basal transcription machinery.' Which disease is connected to the gene identified by this specific evidence through genomic alterations? | sarcoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04315","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SAFB interacts with multiple genes. One interaction is supported by evidence stating: 'Instead, SAFB1RD was found to interact with TAFII68, a member ... | |
medium_divergent_branch_04316 | UHRF1 interacts with multiple proteins. One specific interaction partner is characterized by complex binding dynamics where its C-terminal domain mediates interaction with the TS-domain of Dnmt1, and its TRAF-domain binds to the SRA-domain of UHRF1. Which disease is associated with genomic alterations in this specific ... | intellectual disability | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04316","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UHRF1 interacts with multiple proteins. One specific interaction partner is characterized by complex binding dynamics where its C-terminal domain med... | |
medium_divergent_branch_04317 | S100A8 interacts with multiple proteins. One interaction involves a partner that, in complex with S100A8 (also known as MRP8), promotes the polymerization of microtubules. Which protein is encoded by the gene corresponding to this specific binding partner? | Protein S100-A9 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04317","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"S100A8 interacts with multiple proteins. One interaction involves a partner that, in complex with S100A8 (also known as MRP8), promotes the polymeriz... | |
medium_divergent_branch_04318 | The biological process 'positive regulation of erythrocyte clearance' is defined as any process that activates or increases the frequency, rate, or extent of erythrocyte clearance. This process is a subtype of two distinct higher-level biological processes. One of these parent processes is directly involved in the stru... | tissue remodeling | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04318","source_qa_id":"medium_divergent_branch_02431","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'positive regulation of erythrocyte clearance' is defined as any process t... | |
medium_divergent_branch_04319 | The IgD immunoglobulin complex is absent from the plasma membrane of more than one cell type. One of these cell types is defined as a B cell that is surface IgM-positive, surface IgD-negative, and has not undergone immunoglobulin class switching or peripheral antigen encounter and activation. Which cell type does this ... | small pre-B-II cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04319","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The IgD immunoglobulin complex is absent from the plasma membrane of more than one cell type. One of these cell types is defined as a B cell that is ... | |
medium_divergent_branch_04320 | KCNK1 is associated with multiple cellular components via the 'located in' relationship. One of these associations is supported by evidence stating: 'Unlike other K(+) channel structures, K2P1 is dimeric.' Which cellular component, connected to the component supported by this evidence through an 'is a' relationship, is... | cation channel complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04320","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KCNK1 is associated with multiple cellular components via the 'located in' relationship. One of these associations is supported by evidence stating: ... | |
medium_divergent_branch_04321 | DBNL interacts with multiple genes. One interaction is supported by evidence stating: 'We found that the kinase interacting with DBNL bound to HIP-55 both in vitro and in vivo.' Which cellular component is the gene identified by this evidence located in? | membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04321","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DBNL interacts with multiple genes. One interaction is supported by evidence stating: 'We found that the kinase interacting with DBNL bound to HIP-55... | |
medium_divergent_branch_04322 | CLNS1A interacts with multiple genes. One of these interaction partners is characterized by evidence stating that JBP1 binds SmD1 and SmD3 via their RG domains, while pICln binds the Sm domains. Which disease is associated with this specific gene through genomic alterations? | Cerebro-costo-mandibular syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04322","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CLNS1A interacts with multiple genes. One of these interaction partners is characterized by evidence stating that JBP1 binds SmD1 and SmD3 via their ... | |
medium_divergent_branch_04323 | The gene SPG7 is associated with multiple biological processes. One specific association is supported by evidence stating that SPG7 directs the m-AAA complex to favor association with the mitochondrial Ca2+ uniporter (MCU), and that MCU processing regulates higher order MCU-complex formation. Which biological process, ... | regulation of calcium ion transmembrane transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04323","source_qa_id":"medium_divergent_branch_05457","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene SPG7 is associated with multiple biological processes. One specific association is suppo... | |
medium_divergent_branch_04324 | DNMT3B interacts with multiple proteins. One interaction is supported by evidence stating: 'To comprehend the underlying regulatory mechanism of Dnmt3b, we isolated [PROTEIN_A] and Ubc9 as Dnmt3b-interacting proteins using yeast two-hybrid screens.' Which protein, connected to DNMT3B via an interaction, is encoded by t... | Small ubiquitin-related modifier 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04324","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DNMT3B interacts with multiple proteins. One interaction is supported by evidence stating: 'To comprehend the underlying regulatory mechanism of Dnmt... | |
medium_divergent_branch_04325 | MYBL2 interacts with multiple proteins. One interaction is supported by evidence stating: 'A large proportion of B-Myb formed complexes with the protein encoded by RBL1 in cotransfected cells, however, B-Myb bound weakly to the related p130 protein and not at all to pRb.' Which protein, encoded by the gene connected to... | Retinoblastoma-like protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04325","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MYBL2 interacts with multiple proteins. One interaction is supported by evidence stating: 'A large proportion of B-Myb formed complexes with the prot... | |
medium_divergent_branch_04326 | LMAN1 interacts with multiple proteins. One specific interaction partner is localized to the ERGIC through a direct, calcium-dependent interaction with LMAN1. Which disease is associated with this specific interaction partner? | factor 5 and Factor VIII, combined deficiency of, 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04326","source_qa_id":"medium_divergent_branch_04301","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"LMAN1 interacts with multiple proteins. One specific interaction partner is localized to the ERGI... | |
medium_divergent_branch_04327 | GRB10 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we identified 14-3-3 as a binding partner of GRB10 by employing a yeast two-hybrid screen.' Which protein, among those interacting with GRB10, is the one described in this evidence? | 14-3-3 protein epsilon | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04327","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GRB10 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we identified 14-3-3 as a binding partner of... | |
medium_divergent_branch_04328 | SCAMP2 interacts with multiple genes. One of these interacting partners has experimental evidence indicating that it can be co-immunoprecipitated with SCAMP2 following detergent solubilization, using antibodies that specifically react with only one of the variants. Which protein is encoded by this interacting gene? | Secretory carrier-associated membrane protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04328","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SCAMP2 interacts with multiple genes. One of these interacting partners has experimental evidence indicating that it can be co-immunoprecipitated wit... | |
medium_divergent_branch_04329 | CEBPE interacts with multiple proteins. One interaction is supported by evidence stating that C/EBPepsilon associates with other C/EBP family members and proteins containing a leucine-zipper motif, specifically listing CREB2, the hidden candidate, E6TP1, and AF-17. What is the protein encoded by the hidden candidate? | Protein LDOC1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04329","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CEBPE interacts with multiple proteins. One interaction is supported by evidence stating that C/EBPepsilon associates with other C/EBP family members... | |
medium_divergent_branch_04330 | The FOS protein interacts with multiple partners. One specific interaction partner is characterized by its ability to target c-Fos for polyubiquitylation, thereby regulating c-Fos protein levels. Which protein is encoded by the gene corresponding to this specific interaction partner? | Lysine-specific demethylase 2B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04330","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The FOS protein interacts with multiple partners. One specific interaction partner is characterized by its ability to target c-Fos for polyubiquityla... | |
medium_divergent_branch_04331 | PEG10 interacts with multiple genes. One of these interacting partners is described as a mediator of apoptosis, and experimental evidence indicates that PEG10 protein associates with this partner, while overexpression of PEG10 decreases the cell death mediated by this partner. Which protein is encoded by this specific ... | E3 ubiquitin-protein ligase SIAH1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04331","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PEG10 interacts with multiple genes. One of these interacting partners is described as a mediator of apoptosis, and experimental evidence indicates t... | |
medium_divergent_branch_04332 | PRKCD interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we demonstrate that PKCdeltaCF associates with p73beta, a structural and functional homologue of the p53 tumor suppressor.' Which protein is encoded by the gene that interacts with PRKCD in this specific context? | Tumor protein p73 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04332","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRKCD interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we demonstrate that PKCdeltaCF associates with p73bet... | |
medium_divergent_branch_04333 | CSN3 interacts with multiple genes. One interaction is supported by evidence stating: 'By performing a two-hybrid screen with Int-6 as bait, we have isolated subunits belonging to all three complexes, namely eIF3-p110, Rpt4, CSN3 and CSN6.' Which protein is encoded by the gene that interacts with CSN3 in this context? | Eukaryotic translation initiation factor 3 subunit E | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04333","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CSN3 interacts with multiple genes. One interaction is supported by evidence stating: 'By performing a two-hybrid screen with Int-6 as bait, we have ... | |
medium_divergent_branch_04334 | NEK1 is reported to interact with multiple genes. One specific interaction is supported by evidence stating that the two proteins were found to interact by co-immunoprecipitation (coIP), and their binding affinity increases following cellular exposure to hydrogen peroxide (H2O2). Which gene is linked to NEK1 by this sp... | TLK1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04334","source_qa_id":"medium_divergent_branch_01295","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"NEK1 is reported to interact with multiple genes. One specific interaction is supported by eviden... | |
medium_divergent_branch_04335 | The gene MPDU1 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 66.78 TPM, a z-score of 1.68, and a fold enrichment of 2.60. Which cell type, connected to MPDU1 via this specific enrichment evidence, has a 'develops from' relationship with another cell type? | intermediate monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04335","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene MPDU1 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 66.78 TPM, a z-score of ... | |
medium_divergent_branch_04336 | The gene XIAP interacts with multiple other genes. One of these interacting partners is a protein that binds to the BIR2 domain of XIAP via an IAP-binding motif; mutation of this motif impairs the antiapoptotic function of the interacting protein. Which cell type is enriched for the expression of this specific interact... | natural killer cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04336","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene XIAP interacts with multiple other genes. One of these interacting partners is a protein that binds to the BIR2 domain of XIAP via an IAP-bi... | |
medium_divergent_branch_04337 | The gene NKX2-5 is involved in multiple biological processes. One of these processes is supported by evidence stating that mutant mice display a hypoplastic atrioventricular (AV) node at birth and subsequently develop selective dropout of conduction cells. Which anatomical structure is the result of the development ass... | conducting system of heart | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04337","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene NKX2-5 is involved in multiple biological processes. One of these processes is supported by evidence stating that mutant mice display a hypo... | |
medium_divergent_branch_04338 | NUDT8 is enriched in multiple cell types. One of these cell types exhibits a mean expression of 11.52 TPM, a z-score of 1.78, and a fold enrichment of 3.86. Which broader cell lineage is this specific cell type a subtype of? | dendritic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04338","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NUDT8 is enriched in multiple cell types. One of these cell types exhibits a mean expression of 11.52 TPM, a z-score of 1.78, and a fold enrichment o... | |
medium_divergent_branch_04339 | NTRK2 interacts with multiple genes. One interaction is supported by evidence stating: 'Here we show that the sorting receptor sortilin interacts with TrkA, TrkB and TrkC and enables their anterograde axonal transport, thereby enhancing neurotrophin signaling.' Which disease is connected to the gene identified by this ... | Ischemic stroke | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04339","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NTRK2 interacts with multiple genes. One interaction is supported by evidence stating: 'Here we show that the sorting receptor sortilin interacts wit... | |
medium_divergent_branch_04341 | The gene ILK is reported to bind to multiple partners. One specific interaction is described by the evidence: 'CH-ILKBP interacts with ILK in vitro and in vivo, and the ILK COOH-terminal domain and the CH-ILKBP CH2 domain mediate the interaction.' Based on this specific evidence, which cellular component is the interac... | focal adhesion | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04341","source_qa_id":"medium_divergent_branch_00913","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene ILK is reported to bind to multiple partners. One specific interaction is described by t... | |
medium_divergent_branch_04342 | The protein DAB2 is involved in multiple biological processes. One of these processes is supported by evidence stating that forced re-expression of human DAB2, which is not targeted by the mouse siRNA sequence, rescues cells from apoptosis. Which biological process is negatively regulated by this specific DAB2-associat... | apoptotic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04342","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein DAB2 is involved in multiple biological processes. One of these processes is supported by evidence stating that forced re-expression of h... | |
medium_divergent_branch_04343 | ACTBL2 interacts with multiple genes. One specific interaction is supported by evidence stating that actin beta-like 2 (ACTBL2) competes with RBCK1 for binding to this partner, a process that leads to p65 stabilization. Which cell type is the gene involved in this specific competitive binding interaction enriched in? | non-classical monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04343","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ACTBL2 interacts with multiple genes. One specific interaction is supported by evidence stating that actin beta-like 2 (ACTBL2) competes with RBCK1 f... | |
medium_divergent_branch_04344 | The oviduct is a tubular structure connecting the ovaries to the exterior of the body. One of its broader anatomical classifications is defined by this tubular nature. Which larger anatomical entity is this specific tubular classification a part of? | tube | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04344","source_qa_id":"medium_divergent_branch_00217","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The oviduct is a tubular structure connecting the ovaries to the exterior of the body. One of its... | |
medium_divergent_branch_04345 | The gene TNNC1 interacts with multiple partners. One specific interaction is supported by evidence stating that Cardiac troponin I (cTnI) is the inhibitory component of the troponin complex, and its interaction with cardiac troponin C (cTnC) plays a critical role in transmitting the Ca(2+) signal to the other myofilame... | Troponin I, slow skeletal muscle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04345","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TNNC1 interacts with multiple partners. One specific interaction is supported by evidence stating that Cardiac troponin I (cTnI) is the inhi... | |
medium_divergent_branch_04346 | OTUD1 interacts with multiple proteins. One specific interaction is characterized by OTUD1 directly binding to the partner protein and cleaving polyubiquitin chains from it, a process that leads to the activation of the canonical NF-κB and MAPK pathways. Which protein corresponds to this specific interaction partner? | Caspase recruitment domain-containing protein 9 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04346","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"OTUD1 interacts with multiple proteins. One specific interaction is characterized by OTUD1 directly binding to the partner protein and cleaving polyu... | |
medium_divergent_branch_04347 | HIPK1 is associated with multiple biological processes. One association is supported by evidence stating: 'These data indicate that Hipk1 and Hipk2 are involved in regulation of eye size, lens formation and retinal lamination during late embryogenesis.' Which biological process, connected to HIPK1 via an 'involved in' ... | sensory organ development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04347","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HIPK1 is associated with multiple biological processes. One association is supported by evidence stating: 'These data indicate that Hipk1 and Hipk2 a... | |
medium_divergent_branch_04348 | TRIM13 interacts with multiple genes. One of these interacting partners has a confirmed interaction with TRIM13 via co-immunoprecipitation, specifically involving the protein encoded by NR4A1. Which disease is genetically associated with this specific interacting partner? | mitral valve prolapse | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04348","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM13 interacts with multiple genes. One of these interacting partners has a confirmed interaction with TRIM13 via co-immunoprecipitation, specifica... | |
medium_divergent_branch_04349 | ZBTB16 interacts with multiple proteins. One of these interaction partners is known to be a corepressor, and evidence suggests that the interaction between this corepressor and transcription factors can be disrupted by phosphorylation through the activation of RTK pathways. Which protein is encoded by the gene correspo... | Nuclear receptor corepressor 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04349","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZBTB16 interacts with multiple proteins. One of these interaction partners is known to be a corepressor, and evidence suggests that the interaction b... | |
medium_divergent_branch_04350 | Optineurin (OPTN) is associated with multiple biological processes. One specific association is supported by evidence stating: 'These results show that optineurin links myosin VI to the Golgi complex and plays a central role in Golgi ribbon formation and exocytosis.' Based on this evidence, which biological process is ... | protein localization to organelle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04350","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Optineurin (OPTN) is associated with multiple biological processes. One specific association is supported by evidence stating: 'These results show th... | |
medium_divergent_branch_04351 | SIAH2 interacts with multiple proteins. One interaction partner is identified in a study as a serine/threonine kinase that phosphorylates SIAH2 at five specific residues (Ser16, Thr26, Ser28, Ser68, and Thr119). Which protein, encoded by the gene corresponding to this kinase, is connected to SIAH2? | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04351","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SIAH2 interacts with multiple proteins. One interaction partner is identified in a study as a serine/threonine kinase that phosphorylates SIAH2 at fi... | |
medium_divergent_branch_04352 | NCOA1 interacts with multiple proteins. One interaction is supported by evidence stating: 'A mammalian two-hybrid assay was utilized to assess the ability of the interacting partner to recruit SRC-1 in a ligand-dependent manner.' Which protein product is encoded by the gene corresponding to the interacting partner desc... | Bile acid receptor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04352","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NCOA1 interacts with multiple proteins. One interaction is supported by evidence stating: 'A mammalian two-hybrid assay was utilized to assess the ab... | |
medium_divergent_branch_04353 | Lipoprotein lipase (LPL) is associated with multiple biological processes. One specific association is supported by evidence stating that LPL is a key factor in mediating macrophage lipid accumulation and foam-cell formation from native VLDL particles. Which biological process, connected to LPL via this specific eviden... | macrophage derived foam cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04353","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Lipoprotein lipase (LPL) is associated with multiple biological processes. One specific association is supported by evidence stating that LPL is a ke... | |
medium_divergent_branch_04354 | PDZK1 interacts with multiple proteins. One specific interaction involves a scavenger receptor of class B, type I, which was shown to bind to a PDZ domain-containing protein identified as PDZK1 (also known as CLAMP, Diphor-1, CAP70, or NaPi-Cap1). Although the in vivo functional significance of this interaction for thi... | Scavenger receptor class B member 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04354","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PDZK1 interacts with multiple proteins. One specific interaction involves a scavenger receptor of class B, type I, which was shown to bind to a PDZ d... | |
medium_divergent_branch_04355 | CCR1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'Overexpression of PLP2/A4 stimulated a twofold increase in the agonist-induced migration of HOS/CCR1 cells, implicating a functional role for PLP2/A4 in the chemotactic processes via CCR1.' Based on this e... | taxis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04355","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CCR1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'Overexpression of PLP2/A4 stimulat... | |
medium_divergent_branch_04356 | STK35 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Yeast two-hybrid analysis indicated a highly specific association between Clik1 and a protein encoded by the gene linked to PDLIM1, which was identified in 36 out of 37 Clik1-interacting clones.' Which protein correspond... | PDZ and LIM domain protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04356","source_qa_id":"medium_divergent_branch_00894","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"STK35 interacts with multiple proteins. One specific interaction is supported by evidence stating... | |
medium_divergent_branch_04357 | HCK interacts with multiple proteins. One interaction is supported by evidence stating: 'Using purified proteins, we confirmed that WASP-interacting protein and the interaction partner interact directly with the SH3 domain of Hck.' Which protein, connected to HCK via this interaction, is encoded by the gene associated ... | Engulfment and cell motility protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04357","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HCK interacts with multiple proteins. One interaction is supported by evidence stating: 'Using purified proteins, we confirmed that WASP-interacting ... | |
medium_divergent_branch_04358 | PPM1A interacts with multiple proteins. One specific interaction is supported by evidence stating that the interacting partner was found to interact with PPM1A, and that down-regulation of this partner inhibited the ubiquitination of PPM1A. Which protein corresponds to this specific interaction partner? | E3 ubiquitin-protein ligase TRIM52 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04358","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PPM1A interacts with multiple proteins. One specific interaction is supported by evidence stating that the interacting partner was found to interact ... | |
medium_divergent_branch_04359 | FBXO45 interacts with multiple proteins. One interaction is described by the statement: 'Here we report that FBXO45, the human ortholog of FSN-1, binds specifically to the protein encoded by TP73 triggering its proteasome-dependent degradation.' Which protein is encoded by the gene that interacts with FBXO45 in this sp... | Tumor protein p73 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04359","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBXO45 interacts with multiple proteins. One interaction is described by the statement: 'Here we report that FBXO45, the human ortholog of FSN-1, bin... | |
medium_divergent_branch_04360 | NFKB1 interacts with multiple genes. One interaction is supported by evidence stating: 'Through in vitro binding experiments, a gene encoding a SWI/SNF complex subunit was found to bind to several SWI/SNF complex subunits and also to the p52 NF-kappaB subunit through its nuclear localization signal containing the N-ter... | Coffin-Siris syndrome 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04360","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NFKB1 interacts with multiple genes. One interaction is supported by evidence stating: 'Through in vitro binding experiments, a gene encoding a SWI/S... | |
medium_divergent_branch_04361 | DYRK1A is associated with multiple biological processes. One specific association is supported by evidence stating that 'Both phosphorylation events are dependent on the activity of the DYRK1A kinase that antagonizes HP1-mediated transcriptional repression.' Identify the biological process linked to this specific assoc... | heterochromatin formation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04361","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DYRK1A is associated with multiple biological processes. One specific association is supported by evidence stating that 'Both phosphorylation events ... | |
medium_divergent_branch_04362 | The gene IGHJ6 is enriched in multiple cell types. One specific cell type shows a mean expression of 91.46 TPM, a z-score of 2.02, and a fold enrichment of 5.47. Which anatomical structure is the cell type matching these statistics a part of? | primary nodular lymphoid tissue | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04362","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene IGHJ6 is enriched in multiple cell types. One specific cell type shows a mean expression of 91.46 TPM, a z-score of 2.02, and a fold enrichm... | |
medium_divergent_branch_04363 | The gene CHM is known to interact with multiple Rab GTPases. One specific interaction was characterized by introducing point mutations into the partner protein to serve as a model Rab, then assessing the mutants' ability to interact with REP using a yeast two-hybrid system and an in vitro prenylation assay. Which disea... | cocaine dependence | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04363","source_qa_id":"medium_divergent_branch_03535","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene CHM is known to interact with multiple Rab GTPases. One specific interaction was charact... | |
medium_divergent_branch_04364 | USP49 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Finally, we report new binding partners of USP49, including ribophorin 1, this interaction partner, and different centrins.' Identify the disease associated with this interaction partner through a biomarker relationship. | aneuploidy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04364","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP49 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Finally, we report new binding partners of USP49, in... | |
medium_divergent_branch_04365 | CEACAM1 is associated with multiple cellular components via the 'located in' relationship. One association is supported by evidence stating that Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1/CD66a), expressed on leukocytes, epithelia, and endothelia, mediates homophilic cell adhesion. Which cellula... | cell periphery | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04365","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CEACAM1 is associated with multiple cellular components via the 'located in' relationship. One association is supported by evidence stating that Carc... | |
medium_divergent_branch_04366 | ZMYM2 interacts with multiple genes. One of these interaction partners was identified in a study reporting seven novel FOXP-interacting transcription factors (NR2F1, NR2F2, SATB1, SATB2, SOX5, YY1, and this gene), noting that five of these have well-established roles in cortical development. Which disease is associated... | childhood apraxia of speech | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04366","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZMYM2 interacts with multiple genes. One of these interaction partners was identified in a study reporting seven novel FOXP-interacting transcription... | |
medium_divergent_branch_04367 | The protein RPS3 is involved in multiple biological processes. One specific connection is supported by evidence stating: 'Transient expression of GFP-rpS3 activates caspase-8/caspase-3 and sensitizes cytokine-induced apoptosis.' Identify the biological process that is positively regulated by the process linked to RPS3 ... | apoptotic signaling pathway | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04367","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein RPS3 is involved in multiple biological processes. One specific connection is supported by evidence stating: 'Transient expression of GFP... | |
medium_divergent_branch_04368 | HOXB1 interacts with multiple proteins. One specific interaction is supported by evidence describing the formation of a ternary complex involving Prep1, HOXB1, and the interacting partner on a HOXB1-responsive target in vitro. Which disease is associated with this interacting partner via a biomarker relationship? | acute leukemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04368","source_qa_id":"medium_divergent_branch_07415","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"HOXB1 interacts with multiple proteins. One specific interaction is supported by evidence describ... | |
medium_divergent_branch_04369 | ZBTB16 (PLZF) interacts with multiple proteins. One interaction is supported by evidence stating: 'We here asked whether class II histone deacetylases, known to be generally involved in differentiation processes, participate in the repression mediated by PLZF and PLZF-RARalpha, and found that PLZF interacts with this p... | Histone deacetylase 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04369","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZBTB16 (PLZF) interacts with multiple proteins. One interaction is supported by evidence stating: 'We here asked whether class II histone deacetylase... | |
medium_divergent_branch_04370 | hsa-miR-365a-3p is known to regulate more than one cell type. Evidence indicates that in patients with active pulmonary tuberculosis, down-regulation of miR-365 is associated with up-regulated IL-6 expression in mononuclear cells and serum, suggesting miR-365 regulates immune responses via IL-6. Which cell type, connec... | monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04370","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"hsa-miR-365a-3p is known to regulate more than one cell type. Evidence indicates that in patients with active pulmonary tuberculosis, down-regulation... | |
medium_divergent_branch_04371 | NOTCH1 interacts with multiple genes. One of these interaction partners is described as a secreted protein that binds to a region in Notch involved in ligand-mediated receptor activation, thereby acting as an antagonist of Notch signaling. Which cellular component is this specific interaction partner located in? | extracellular matrix | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04371","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NOTCH1 interacts with multiple genes. One of these interaction partners is described as a secreted protein that binds to a region in Notch involved i... | |
medium_divergent_branch_04372 | Dimenhydrinate interacts with multiple drugs. One of these interacting drugs, when combined with Dimenhydrinate, has been shown to reduce the incidence of postoperative nausea and vomiting (PONV) compared with placebo. Which disease is this specific interacting drug indicated for? | gastroesophageal reflux disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04372","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Dimenhydrinate interacts with multiple drugs. One of these interacting drugs, when combined with Dimenhydrinate, has been shown to reduce the inciden... | |
medium_divergent_branch_04373 | PIN1 interacts with multiple genes. One of these interactions is characterized by the following mechanism: the interacting partner physically binds to PIN1 to trigger K63-linked ubiquitination-dependent stabilization of PIN1, which consequently hyperactivates the PI3K/AKT signaling axis. Which gene is this interacting ... | HAT1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04373","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PIN1 interacts with multiple genes. One of these interactions is characterized by the following mechanism: the interacting partner physically binds t... | |
medium_divergent_branch_04374 | TRPS1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that two distinct regions of TRPS1 can physically interact with the dynein light chain 8 protein, LC8a, that are at least 458 amino acids apart from each other.' Which disease is associated with the gene corresponding to... | mammary neoplasms, animal | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04374","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRPS1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that two distinct regions of TRPS1 can physically... | |
medium_divergent_branch_04375 | IRF2BP2 interacts with multiple proteins. One interaction is supported by evidence stating: 'We identified interferon response factor 2 binding protein 2 (IRF2BP2) and confirmed its presence in the TEAD4/[Partner Protein] complex in vivo by coimmunoprecipitation and mammalian 2-hybrid assays.' Which protein is the [Par... | Transcription cofactor vestigial-like protein 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04375","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IRF2BP2 interacts with multiple proteins. One interaction is supported by evidence stating: 'We identified interferon response factor 2 binding prote... | |
medium_divergent_branch_04376 | IL10 interacts with multiple proteins. One interaction is supported by evidence stating: 'The two cDNAs are substantially identical and express an approximately 110-kDa polypeptide in COS7 cells, which binds mIL-10 specifically.' Which protein product is encoded by the gene corresponding to this specific binding partne... | Interleukin-10 receptor subunit alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04376","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IL10 interacts with multiple proteins. One interaction is supported by evidence stating: 'The two cDNAs are substantially identical and express an ap... | |
medium_divergent_branch_04377 | ITGB1 interacts with multiple genes. One specific interaction is supported by evidence stating that BirA-BioID followed by mass-spectrometry revealed Integrin Beta-1 (ITGB1) and Protein Kinase C Delta (PRKCD) as direct molecular and functional partners of the interacting gene, supporting GBC cell migration. Which disea... | bone osteosarcoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04377","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ITGB1 interacts with multiple genes. One specific interaction is supported by evidence stating that BirA-BioID followed by mass-spectrometry revealed... | |
medium_divergent_branch_04378 | TMEM33 interacts with multiple genes. One of these interaction partners is reported to co-assemble with TMEM43, ENDOD1, and TMED1 to form a complex that modulates innate immune signaling through the cGAS-STING pathway. Which cellular component is this specific interaction partner located in? | endoplasmic reticulum membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04378","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TMEM33 interacts with multiple genes. One of these interaction partners is reported to co-assemble with TMEM43, ENDOD1, and TMED1 to form a complex t... | |
medium_divergent_branch_04379 | PAWR interacts with multiple genes. One interaction is supported by evidence stating: 'Substrate recognition sites for the SPRY domain are identified only for human Par-4 (ELNNNL) and for the Drosophila orthologue GUSTAVUS binding to the DEAD-box RNA helicase VASA (DINNNN).' Which cellular component is the gene associa... | cytosol | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04379","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PAWR interacts with multiple genes. One interaction is supported by evidence stating: 'Substrate recognition sites for the SPRY domain are identified... | |
medium_divergent_branch_04380 | PLCB3 interacts with multiple genes. One of these interacting partners is part of a protein complex where NHERF2, using its second PDZ domain, indirectly links LPA(2) to PLC-beta3, excluding other PLC-beta isozymes. Which disease is associated with this specific interacting gene via a biomarker relationship? | benign neoplasm of stomach | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04380","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PLCB3 interacts with multiple genes. One of these interacting partners is part of a protein complex where NHERF2, using its second PDZ domain, indire... | |
medium_divergent_branch_04381 | ESRRA interacts with multiple proteins. One interaction is supported by evidence stating: 'The two ERRs bind MHRE simultaneously in electrophoretic mobility shift assay (EMSA) and they were detected as multimeric complexes in cells by coimmunoprecipitation.' Which protein product is encoded by the gene that interacts w... | Estrogen-related receptor gamma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04381","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ESRRA interacts with multiple proteins. One interaction is supported by evidence stating: 'The two ERRs bind MHRE simultaneously in electrophoretic m... | |
medium_divergent_branch_04382 | PCBP1 interacts with multiple genes. One of these interacting partners is an E3 ubiquitin ligase that targets PCBP1 for ubiquitination and subsequent degradation. Which biological process is this specific interacting partner involved in? | ubiquitin-dependent protein catabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04382","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PCBP1 interacts with multiple genes. One of these interacting partners is an E3 ubiquitin ligase that targets PCBP1 for ubiquitination and subsequent... | |
medium_divergent_branch_04384 | POLR2C interacts with multiple genes. One interaction is supported by evidence stating: 'In cycling myogenic C2C7 cells, we show that the RPB3 protein directly interacts with the interacting partner within the cytoplasm.' Which cellular component is the gene identified by this evidence located in? | centriole | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04384","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"POLR2C interacts with multiple genes. One interaction is supported by evidence stating: 'In cycling myogenic C2C7 cells, we show that the RPB3 protei... | |
medium_divergent_branch_04385 | The gene KCNJ1 interacts with multiple partners. One specific interaction is supported by evidence stating: 'Immunoprecipitation of renal tissue lysate with ROMK antibody and glutathione S-transferase pulldown experiments demonstrated the association between ROMK and a protein encoded by the interacting gene.' Which pr... | E3 ubiquitin-protein ligase SH3RF1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04385","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene KCNJ1 interacts with multiple partners. One specific interaction is supported by evidence stating: 'Immunoprecipitation of renal tissue lysa... | |
medium_divergent_branch_04387 | BAX interacts with multiple proteins. One interaction partner is supported by evidence showing that a Bcl-2 family protein co-immunoprecipitated from cell lysates with Bax, Bak, Bad, and Bik, whereas A1 bound only Bak and Bik. Which protein is encoded by the gene corresponding to this interaction partner? | Bcl-2-like protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04387","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BAX interacts with multiple proteins. One interaction partner is supported by evidence showing that a Bcl-2 family protein co-immunoprecipitated from... | |
medium_divergent_branch_04388 | EIF3G interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 impairs translation in vivo.' Identify the cellular component where the protein corresponding to this specific interaction is located. | eukaryotic translation initiation factor 3 complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04388","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EIF3G interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Indeed, CIF-1 binds eIF-3.F and inactivation of c... | |
medium_divergent_branch_04389 | HMGB1 is associated with multiple biological processes. One association is supported by evidence showing that treatment with HMGB1 (at concentrations of 0.01, 0.1, 1, or 10 microg/ml for 24 hours, or 10 microg/ml for 6, 12, 24, or 48 hours) resulted in a dose- and time-dependent induction of apoptosis in mouse macropha... | apoptotic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04389","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HMGB1 is associated with multiple biological processes. One association is supported by evidence showing that treatment with HMGB1 (at concentrations... | |
medium_divergent_branch_04390 | ANXA2 interacts with multiple genes. One of these interaction partners was identified as a binding protein for monomeric ANXA2 enriched in 5% O2 via mass spectrometry. Which disease is associated with this specific interaction partner as a therapeutic target? | plasma cell myeloma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04390","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ANXA2 interacts with multiple genes. One of these interaction partners was identified as a binding protein for monomeric ANXA2 enriched in 5% O2 via ... | |
medium_divergent_branch_04391 | RAB11A interacts with multiple proteins. One of these interacting partners is described in literature as being associated with wild-type RAB11A, dominant active RAB11A (Rab11aS20V), Rab11b, and Rab25. Which protein, connected to RAB11A via a binding interaction, is the subject of this specific evidence? | Rab11 family-interacting protein 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04391","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAB11A interacts with multiple proteins. One of these interacting partners is described in literature as being associated with wild-type RAB11A, domi... | |
medium_divergent_branch_04392 | PDIK1L interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Through mass spectrometry analysis of affinity-purified complexes, we identify the kinase paralogs STK35 and PDIK1L as binding partners and substrates of the SCP4 phosphatase domain.' Which protein is encoded by the gen... | CTD small phosphatase-like protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04392","source_qa_id":"medium_divergent_branch_01837","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"PDIK1L interacts with multiple proteins. One specific interaction is supported by evidence statin... | |
medium_divergent_branch_04393 | SNX9 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating that SNX9 is involved in the late stages of clathrin-mediated endocytosis in non-neuronal cells, where it works with the GTPase dynamin to facilitate the formation and scissi... | vesicle membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04393","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SNX9 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating tha... | |
medium_divergent_branch_04394 | PELI3 interacts with multiple genes. One of these interaction partners is characterized by the following mechanism: it localizes to autophagic membranes and interacts with ATG8 proteins through an LC3-interacting region (LIR). Which disease is associated with this specific interaction partner via genomic alterations? | familial Alzheimer disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04394","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PELI3 interacts with multiple genes. One of these interaction partners is characterized by the following mechanism: it localizes to autophagic membra... | |
medium_divergent_branch_04395 | The gene DTL interacts with multiple partners. One specific interaction is supported by evidence stating: 'Mass spectrometry and immunoprecipitation showed that the cell division cycle protein cdt2 (Cdt2), the substrate recognition subunit of the E3 ligase complex associated with cancer, cullin-RING ubiquitin ligase co... | Vacuole membrane protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04395","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene DTL interacts with multiple partners. One specific interaction is supported by evidence stating: 'Mass spectrometry and immunoprecipitation ... | |
medium_divergent_branch_04396 | The ileocolic vein drains blood from multiple anatomical structures. One of these structures is described as a vein that drains the ileum, the structure itself, and the cecum. Which anatomical structure is connected to the ileocolic vein via the 'vessel drains blood from' relationship? | subdivision of digestive tract | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04396","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The ileocolic vein drains blood from multiple anatomical structures. One of these structures is described as a vein that drains the ileum, the struct... | |
medium_divergent_branch_04397 | The gene IL4I1 is associated with multiple biological processes. One specific association is supported by evidence stating that IL4I1 inhibits effector T lymphocyte proliferation and facilitates regulatory T-cell development. Identify the biological process connected to this specific IL4I1-associated process via the re... | T cell activation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04397","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene IL4I1 is associated with multiple biological processes. One specific association is supported by evidence stating that IL4I1 inhibits effect... | |
medium_divergent_branch_04398 | The gene TP73 is known to physically interact with multiple proteins. One specific interaction is described by the statement: 'Here we report that the nuclear phosphoprotein p73 can engage in a physical association with the Yes-associated protein (YAP).' Based on this evidence, which protein product is encoded by the g... | Transcriptional coactivator YAP1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04398","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TP73 is known to physically interact with multiple proteins. One specific interaction is described by the statement: 'Here we report that th... | |
medium_divergent_branch_04399 | CDK2AP2 interacts with multiple proteins. One of these interactions involves a protein that forms a complex with p14(DOC-1R), a connection verified in vitro and in cells. Which protein product is encoded by the gene corresponding to this interacting partner? | Cyclin-dependent kinase 2-associated protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04399","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDK2AP2 interacts with multiple proteins. One of these interactions involves a protein that forms a complex with p14(DOC-1R), a connection verified i... | |
medium_divergent_branch_04400 | EHMT2 interacts with multiple proteins. One interaction is supported by evidence stating: 'The chromatin-enriched G9a can then directly interact with replication protein A (RPA) and promote loading of the RPA and Rad51 recombinase to DSBs.' Which protein, encoded by the gene connected to EHMT2 via this specific interac... | Replication protein A 70 kDa DNA-binding subunit | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04400","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EHMT2 interacts with multiple proteins. One interaction is supported by evidence stating: 'The chromatin-enriched G9a can then directly interact with... | |
medium_divergent_branch_04402 | The gene SYNRG interacts with multiple partners. One specific interaction is supported by evidence stating: 'Yeast two-hybrid analysis showed that the AGEH domains of the GGA proteins as well as those of gamma-adaptins are able to interact with gamma-synergin, which was previously shown to localized in the TGN region a... | ADP-ribosylation factor-binding protein GGA1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04402","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene SYNRG interacts with multiple partners. One specific interaction is supported by evidence stating: 'Yeast two-hybrid analysis showed that th... | |
medium_divergent_branch_04404 | NLRP3 interacts with multiple proteins. One interaction is supported by evidence stating: 'We further observed through immunoprecipitation and siRNA knockdown that autophagic degradation of the NLRP3 inflammasome is dependent on K63 polyubiquitation of its NLRP3 subunit and subsequent binding by the adaptor protein [ad... | Sequestosome-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04404","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NLRP3 interacts with multiple proteins. One interaction is supported by evidence stating: 'We further observed through immunoprecipitation and siRNA ... | |
medium_divergent_branch_04405 | WNT7A is associated with multiple biological processes. One association is supported by evidence stating: 'We found that Wnt-7a was rapidly induced in the wounded cornea, promoted the proliferation of corneal epithelial cells, and enhanced wound closure.' Which biological process, connected to the process described by ... | wound healing | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04405","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WNT7A is associated with multiple biological processes. One association is supported by evidence stating: 'We found that Wnt-7a was rapidly induced i... | |
medium_divergent_branch_04406 | APAF1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that the documented anti-apoptotic effect of the principal heat-shock protein, Hsp70, is mediated through its direct association with the caspase-recruitment domain (CARD) of Apaf-1 and through inhibition of apoptoso... | Heat shock 70 kDa protein 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04406","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"APAF1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that the documented anti-apoptotic effect of ... |
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