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medium_divergent_branch_04407 | The protein EFHC1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'We had previously demonstrated that EFHC1 is a microtubule-associated protein (MAP) involved in cell division and radial migration during cerebral corticogenesis.' Based on this specific evide... | telencephalon cell migration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04407","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein EFHC1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'We had previously dem... | |
medium_divergent_branch_04408 | The gene BUD23 (WBSCR22) interacts with multiple partners. One specific interaction involves a partner whose encoded protein is a methyltransferase that interacts with Merm1, an interaction that represses the methyltransferase activity and requires the binding motif for S-adenosyl-L-methionine. Which protein is encoded... | DNA (cytosine-5)-methyltransferase 3A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04408","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene BUD23 (WBSCR22) interacts with multiple partners. One specific interaction involves a partner whose encoded protein is a methyltransferase t... | |
medium_divergent_branch_04409 | ALDH3A2 interacts with multiple proteins. One of these interaction partners has been experimentally shown to specifically bind members of the ALDH3 family and mediate their polyubiquitylation. Which protein is encoded by the gene corresponding to this specific interaction partner? | F-box/LRR-repeat protein 12 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04409","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ALDH3A2 interacts with multiple proteins. One of these interaction partners has been experimentally shown to specifically bind members of the ALDH3 f... | |
medium_divergent_branch_04411 | MYO10 interacts with multiple proteins. One of these interaction partners is characterized by the finding that the FERM domain of MYO10 is required for its localization and accumulation at filopodia tips. Which protein is this interaction partner? | Ras-associated and pleckstrin homology domains-containing protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04411","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MYO10 interacts with multiple proteins. One of these interaction partners is characterized by the finding that the FERM domain of MYO10 is required f... | |
medium_divergent_branch_04413 | Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.585 and an adjusted p-value of 0.044. For which disease is that selected gene recorded as a biomarker? | prostate cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04413","source_qa_id":"medium_divergent_branch_01811","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fo... | |
medium_divergent_branch_04414 | The gene STC1 is associated with multiple biological processes. One association is supported by evidence stating: 'Taken together, our findings indicate that STC1 inhibits longitudinal bone growth directly at the growth plate.' Identify the biological process linked to STC1 that is consistent with this evidence, and th... | animal organ development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04414","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene STC1 is associated with multiple biological processes. One association is supported by evidence stating: 'Taken together, our findings indic... | |
medium_divergent_branch_04415 | Orthohepevirus A upregulates multiple genes. One such upregulation event is characterized by a log2 fold change of approximately 1.208 and an adjusted p-value of 0.02262. Which disease is associated with the gene exhibiting this specific expression profile? | glioma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04415","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Orthohepevirus A upregulates multiple genes. One such upregulation event is characterized by a log2 fold change of approximately 1.208 and an adjuste... | |
medium_divergent_branch_04416 | CUL4B interacts with multiple genes. One specific interaction is supported by evidence stating: 'Indeed, co-immunoprecipitation experiments and biochemical analysis revealed that LIS1 and this interaction partner interact with DDB1, and their binding is enhanced by the phosphorylated N-terminal domain of CUL4B.' Which ... | periodic fever, immunodeficiency, and thrombocytopenia syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04416","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CUL4B interacts with multiple genes. One specific interaction is supported by evidence stating: 'Indeed, co-immunoprecipitation experiments and bioch... | |
medium_divergent_branch_04418 | LAMP2 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating that LAMP2A functions as a receptor for substrate proteins of chaperone-mediated autophagy within this component. Which cellular component, connected to this specific locati... | lytic vacuole membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04418","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LAMP2 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating th... | |
medium_divergent_branch_04419 | GNA12 interacts with multiple proteins. One interaction partner is described in a study stating: 'We also show that Gα12 can no longer interact with and activate an [protein] mutant with its C-terminal sequence downstream of the kinase domain being replaced with the corresponding CRAF sequence.' Which protein encoded b... | Serine/threonine-protein kinase A-Raf | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04419","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GNA12 interacts with multiple proteins. One interaction partner is described in a study stating: 'We also show that Gα12 can no longer interact with ... | |
medium_divergent_branch_04420 | FBP1 interacts with multiple proteins. One specific interaction is characterized by the following mechanism: the interacting partner promotes aerobic glycolysis in pancreatic cancer cells through direct binding to and ubiquitination of fructose-1,6-bisphosphatase (FBP1). Which protein corresponds to this interacting pa... | E3 ubiquitin-protein ligase TRIM47 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04420","source_qa_id":"medium_divergent_branch_03097","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"FBP1 interacts with multiple proteins. One specific interaction is characterized by the following... | |
medium_divergent_branch_04422 | FBXO5 interacts with multiple genes. One of these interaction partners is described in the following context: 'Here, we show that the APC/C inhibitor Emi1 tightly binds both the APC/C and its Cdh1 activator, binds to the D-box receptor site on the APC/C(Cdh1), and competes with APC/C substrates for D-box binding.' Iden... | colorectal carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04422","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBXO5 interacts with multiple genes. One of these interaction partners is described in the following context: 'Here, we show that the APC/C inhibitor... | |
medium_divergent_branch_04423 | NFE2L1 interacts with multiple genes. One of these interacting partners is known to interact with NRF1, and recombinant forms of this partner have been shown to promote the ubiquitination of retrotranslocated NRF1 in vitro. Which gene is this interacting partner? | IP6K1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04423","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NFE2L1 interacts with multiple genes. One of these interacting partners is known to interact with NRF1, and recombinant forms of this partner have be... | |
medium_divergent_branch_04424 | LAMTOR1 interacts with multiple proteins. One interaction involves a complex termed Ragulator, which is encoded by the MAPKSP1, ROBLD3, and c11orf59 genes. This complex interacts with Rag GTPases, recruits them to lysosomes, and is essential for mTORC1 activation. Which protein, connected to LAMTOR1 through this intera... | Ras-related GTP-binding protein C | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04424","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LAMTOR1 interacts with multiple proteins. One interaction involves a complex termed Ragulator, which is encoded by the MAPKSP1, ROBLD3, and c11orf59 ... | |
medium_divergent_branch_04425 | SKA1 interacts with multiple proteins. One specific interaction partner is characterized by evidence stating that it interacts with SKA1 and that SKA1 is required for its stability in vivo. Which cell type is this specific interaction partner enriched in? | regulatory T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04425","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SKA1 interacts with multiple proteins. One specific interaction partner is characterized by evidence stating that it interacts with SKA1 and that SKA... | |
medium_divergent_branch_04426 | GIT1 interacts with multiple genes. One of these interaction partners is supported by evidence stating that GIT proteins form homo- and heteromultimers through their C-terminal G-protein-coupled receptor kinase-binding domain in a tail-to-tail fashion. Which biological process is the gene corresponding to this specific... | regulation of G protein-coupled receptor signaling pathway | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04426","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GIT1 interacts with multiple genes. One of these interaction partners is supported by evidence stating that GIT proteins form homo- and heteromultime... | |
medium_divergent_branch_04427 | PHRF1 interacts with multiple proteins. One interaction is supported by evidence stating that 'Immunoprecipitation and peptide pull-down assays verify that PHRF1 constitutively binds to di- and trimethylated histone H3 lysine 36 (H3K36) (H3K36me2 and H3K36me3) via its PHD domain.' Which specific histone variant, encode... | Histone H3.1t | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04427","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PHRF1 interacts with multiple proteins. One interaction is supported by evidence stating that 'Immunoprecipitation and peptide pull-down assays verif... | |
medium_divergent_branch_04429 | The gene AGTR1 is associated with multiple biological processes. One association is supported by evidence stating: 'The expressed gene exhibited high-affinity AII and Dup753 binding and was functionally coupled to inositol phosphate turnover.' Identify the biological process described by this evidence. Then, determine ... | signal transduction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04429","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene AGTR1 is associated with multiple biological processes. One association is supported by evidence stating: 'The expressed gene exhibited high... | |
medium_divergent_branch_04430 | TRIM37 interacts with multiple proteins. One specific interaction is characterized by the finding that TRIM37 binds to the partner protein and accelerates its degradation. Which protein is encoded by the gene corresponding to this specific interaction partner? | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04430","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM37 interacts with multiple proteins. One specific interaction is characterized by the finding that TRIM37 binds to the partner protein and accele... | |
medium_divergent_branch_04432 | GFRA1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Finally, we show that NTN, in the presence of NTNR-alpha, induces tyrosine-phosphorylation of the target protein, and that NTN, NTNR-alpha and the target protein form a physical complex on the cell surface.' Which protein product... | Proto-oncogene tyrosine-protein kinase receptor Ret | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04432","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GFRA1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Finally, we show that NTN, in the presence of NTNR-alpha, ... | |
medium_divergent_branch_04434 | PEX1 interacts with multiple proteins. One interaction is supported by evidence stating: 'These results strongly suggest that Pex1p and Pex6p interact with each other.' Which protein, connected to PEX1 via this interaction, is encoded by the gene in question? | Peroxisomal ATPase PEX6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04434","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PEX1 interacts with multiple proteins. One interaction is supported by evidence stating: 'These results strongly suggest that Pex1p and Pex6p interac... | |
medium_divergent_branch_04435 | PDX1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We identified new proteins associated with PDX-1 by mass spectrometry. These proteins, a regulatory subunit of DNA-dependent protein kinase (DNA-PK) and its partner, are regulatory subunits of DNA-dependent protein kinase (DNA-PK)... | XRCC6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04435","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PDX1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We identified new proteins associated with PDX-1 by mass sp... | |
medium_divergent_branch_04436 | COL1A1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We demonstrated through ligand dot blot analysis that type Ialpha collagen binds IGFBP-3.' Which protein is encoded by the gene corresponding to this interacting partner? | Insulin-like growth factor-binding protein 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04436","source_qa_id":"medium_divergent_branch_04128","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"COL1A1 interacts with multiple proteins. One specific interaction is supported by evidence statin... | |
medium_divergent_branch_04437 | CEACAM1 is involved in multiple biological processes. One of these processes is supported by evidence showing that the extinction of SHP-1 expression or the blockade of homophilic binding by CEACAM1 (using a Fab that specifically recognizes the homophilic binding region of human CEACAM1) increases the cytolytic functio... | T cell mediated cytotoxicity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04437","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CEACAM1 is involved in multiple biological processes. One of these processes is supported by evidence showing that the extinction of SHP-1 expression... | |
medium_divergent_branch_04438 | HIST2H3A interacts with multiple proteins. One interaction is supported by evidence stating: 'We identify known histone chaperones and modifying proteins, thereby validating our approach, and find an interaction between soluble histone H3 and this protein, an E3 ubiquitin ligase, mediated by its PHD domain.' What is th... | Putative E3 ubiquitin-protein ligase UBR7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04438","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HIST2H3A interacts with multiple proteins. One interaction is supported by evidence stating: 'We identify known histone chaperones and modifying prot... | |
medium_divergent_branch_04439 | FBXO32 interacts with multiple genes. One of these interaction partners is characterized by evidence stating that it interacts with all three endophilin-A proteins. Which disease is associated with this specific interaction partner via a biomarker relationship? | HER2 positive breast carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04439","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBXO32 interacts with multiple genes. One of these interaction partners is characterized by evidence stating that it interacts with all three endophi... | |
medium_divergent_branch_04440 | MICU1 is associated with multiple biological processes. One specific association is supported by evidence stating that silencing MICU1 does not disrupt mitochondrial respiration or membrane potential but abolishes mitochondrial calcium entry in intact and permeabilized cells. Which biological process is a parent term (... | calcium ion transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04440","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MICU1 is associated with multiple biological processes. One specific association is supported by evidence stating that silencing MICU1 does not disru... | |
medium_divergent_branch_04441 | SLC30A9 interacts with multiple proteins. One of these interaction partners is described in the literature as being associated with ZNT9 (Zinc Transporter 9), a coactivator of β-catenin-mediated gene transcription. Which protein, connected to SLC30A9 via an interaction, is the subject of this mechanistic description? | BTB/POZ domain-containing protein KCTD9 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04441","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SLC30A9 interacts with multiple proteins. One of these interaction partners is described in the literature as being associated with ZNT9 (Zinc Transp... | |
medium_divergent_branch_04442 | PTK2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Finally, we correlated FAK, Pyk2, and the chimeric protein binding to talin, but not paxillin, with their regulation by integrins and focal contact localization.' Which protein, encoded by the gene connected to PTK2 via this speci... | Talin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04442","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PTK2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Finally, we correlated FAK, Pyk2, and the chimeric protein ... | |
medium_divergent_branch_04443 | RASA3 interacts with multiple proteins. One interaction is supported by evidence stating: 'GAP was present in WT [protein] immunoprecipitates from the co-infected cells, indicative of [protein].GAP complex formation.' Which disease is associated with this specific interacting protein? | autoinflammation with pulmonary and cutaneous vasculitis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04443","source_qa_id":"medium_divergent_branch_02705","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"RASA3 interacts with multiple proteins. One interaction is supported by evidence stating: 'GAP wa... | |
medium_divergent_branch_04444 | BRAF interacts with multiple proteins. One interaction is supported by evidence stating: 'Members of the raf oncogene family encode serine/threonine protein kinases, which activate the mitogen-activated protein kinase kinase MEKs (MAPK or ERK kinases) through direct interaction and phosphorylation.' Which protein produ... | Dual specificity mitogen-activated protein kinase kinase 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04444","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BRAF interacts with multiple proteins. One interaction is supported by evidence stating: 'Members of the raf oncogene family encode serine/threonine ... | |
medium_divergent_branch_04445 | GATA6 is associated with multiple biological processes. One specific association is supported by evidence stating: 'When overexpressed in immortalised human sebocytes, GATA6 triggers a junctional zone and sebaceous differentiation program whilst limiting lipid production and cell proliferation.' Which cell type is the ... | sebaceous gland cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04445","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GATA6 is associated with multiple biological processes. One specific association is supported by evidence stating: 'When overexpressed in immortalise... | |
medium_divergent_branch_04446 | MAGT1 interacts with multiple proteins. One interaction partner is a subunit of the oligosaccharyltransferase (OST) complex and is required for Dengue virus (DENV) propagation. Which disease is associated with this specific interaction partner? | STT3B-congenital disorder of glycosylation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04446","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAGT1 interacts with multiple proteins. One interaction partner is a subunit of the oligosaccharyltransferase (OST) complex and is required for Dengu... | |
medium_divergent_branch_04447 | ANGPTL8 is associated with multiple biological processes. One association is supported by evidence stating: 'The findings that plasma triglyceride levels are reduced by Angptl8 deletion and increased following ANGPTL8 overexpression support the possibility that inhibition of ANGPTL8 represents a therapeutic strategy fo... | regulation of primary metabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04447","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ANGPTL8 is associated with multiple biological processes. One association is supported by evidence stating: 'The findings that plasma triglyceride le... | |
medium_divergent_branch_04448 | ATF3 interacts with multiple genes. One interaction is characterized by the following evidence: 'As confirmed by the GST pull-down assay, ATF3 bound to the DNA-binding domain of a p53 family member, resulting in the activation of p21 or Bax transcription, a downstream target of this protein.' Which disease is causally ... | aneuploidy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04448","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATF3 interacts with multiple genes. One interaction is characterized by the following evidence: 'As confirmed by the GST pull-down assay, ATF3 bound ... | |
medium_divergent_branch_04449 | The protein BAD interacts with multiple partners. One interaction is supported by evidence stating: 'Here we report that multiple isoforms of 14-3-3 proteins were capable of binding to several ligands, Bad, Raf-1, and Cbl.' In this context, the binding partner of BAD is a specific isoform of the 14-3-3 protein family. ... | papilloma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04449","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein BAD interacts with multiple partners. One interaction is supported by evidence stating: 'Here we report that multiple isoforms of 14-3-3 ... | |
medium_divergent_branch_04450 | ARL1 is known to bind multiple protein partners. One specific interaction involves ARL1-GTP binding to the GRIP domains of Golgin-97 and a second golgin protein, a process that depends on conserved residues within these GRIP domains essential for Golgi targeting. Which disease is associated with the gene encoding the s... | melanoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04450","source_qa_id":"medium_divergent_branch_01977","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ARL1 is known to bind multiple protein partners. One specific interaction involves ARL1-GTP bindi... | |
medium_divergent_branch_04451 | RAF1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we report that multiple isoforms of 14-3-3 proteins were capable of binding to several ligands, Bad, Raf-1, and Cbl.' Which protein, encoded by the gene connected to RAF1 via this specific binding interaction, is the subject ... | 14-3-3 protein eta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04451","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAF1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we report that multiple isoforms of 14-3-3 proteins we... | |
medium_divergent_branch_04452 | GNB4 interacts with multiple proteins. One interaction is supported by evidence stating: 'In vitro translation co-precipitation analyses revealed that Gbeta4 can form stable dimers with Ggamma1, Ggamma2, Ggamma3, Ggamma4, Ggamma5, Ggamma7, Ggamma10, Ggamma11, Ggamma12, and Ggamma13, dimers which were also able to stimu... | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04452","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GNB4 interacts with multiple proteins. One interaction is supported by evidence stating: 'In vitro translation co-precipitation analyses revealed tha... | |
medium_divergent_branch_04455 | SMARCE1 interacts with multiple proteins. One interaction is supported by evidence stating: 'A functional characterisation of the truncated BAF57 showed that it has lost the ability to bind to ER but still binds to the nuclear receptor coactivator SRC1e.' Which protein, encoded by the gene connected to SMARCE1 via this... | Nuclear receptor coactivator 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04455","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMARCE1 interacts with multiple proteins. One interaction is supported by evidence stating: 'A functional characterisation of the truncated BAF57 sho... | |
medium_divergent_branch_04456 | The tunica fibrosa of the eyeball consists of two primary anatomical components. One component is described as opaque and constituting the posterior five-sixths of the tunic, while the other is transparent and forms the anterior sixth. Which of these two components contributes to the morphology of the anterior segment ... | anterior segment of eyeball | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04456","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The tunica fibrosa of the eyeball consists of two primary anatomical components. One component is described as opaque and constituting the posterior ... | |
medium_divergent_branch_04457 | UBN1 interacts with multiple histone H3 variants. One specific interaction is supported by evidence stating: 'Here, we show that, before deposition, H3.3 exists in two biochemically distinct complexes, associated with either Daxx or HIRA, Ubinuclein-1, and Cabin-1.' Which protein is encoded by the gene corresponding to... | Histone H3.3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04457","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBN1 interacts with multiple histone H3 variants. One specific interaction is supported by evidence stating: 'Here, we show that, before deposition, ... | |
medium_divergent_branch_04458 | CDC42EP2 is involved in multiple biological processes. One of these processes is supported by evidence stating that the expression of CEP2, CEP3, CEP4, and CEP5 in NIH-3T3 fibroblasts induces pseudopodia formation. Which biological process is positively regulated by the process linked to this evidence? | pseudopodium assembly | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04458","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDC42EP2 is involved in multiple biological processes. One of these processes is supported by evidence stating that the expression of CEP2, CEP3, CEP... | |
medium_divergent_branch_04459 | The biological process 'antigen processing and presentation of peptide or polysaccharide antigen via MHC class II' is enabled by multiple cell types. One of these cell types is described as a cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response. What is... | leukocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04459","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The biological process 'antigen processing and presentation of peptide or polysaccharide antigen via MHC class II' is enabled by multiple cell types.... | |
medium_divergent_branch_04460 | The FAS gene interacts with multiple proteins. One of these interacting proteins binds to the cytoplasmic juxtamembrane domain of FAS and interferes with the recruitment of FADD to FAS. Which protein is encoded by the gene that interacts with FAS in this specific manner? | Thyroid receptor-interacting protein 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04460","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The FAS gene interacts with multiple proteins. One of these interacting proteins binds to the cytoplasmic juxtamembrane domain of FAS and interferes ... | |
medium_divergent_branch_04461 | Orthohepevirus A is reported to upregulate multiple genes. One specific upregulation event is characterized by a log2 fold change of approximately 1.179 and an adjusted p-value of approximately 0.043. Which cell type is the target gene of this specific upregulation event enriched in? | plasmacytoid dendritic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04461","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Orthohepevirus A is reported to upregulate multiple genes. One specific upregulation event is characterized by a log2 fold change of approximately 1.... | |
medium_divergent_branch_04462 | The erythropoietin receptor (EPOR) interacts with multiple proteins. One specific interaction involves a Src family tyrosine kinase that physically associates with EPOR in Epo-dependent hematopoietic cell lines, such as 32D/EpoR-Wt and F36E. Which disease is associated with this specific interacting protein through gen... | diffuse large B-cell lymphoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04462","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The erythropoietin receptor (EPOR) interacts with multiple proteins. One specific interaction involves a Src family tyrosine kinase that physically a... | |
medium_divergent_branch_04464 | CSPG5 interacts with multiple genes. One of these interaction partners is supported by evidence showing that CALEB/NGC interacts with a specific protein in a yeast two-hybrid system. Which gene, connected to CSPG5 via this specific evidence, is known to bind to another protein? | RHOQ | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04464","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CSPG5 interacts with multiple genes. One of these interaction partners is supported by evidence showing that CALEB/NGC interacts with a specific prot... | |
medium_divergent_branch_04465 | RNF168 interacts with multiple genes. One interaction is supported by evidence stating: 'We show that this protein indirectly recognizes histone ubiquitylation by physically associating with ubiquitin-bound RNF168.' Which biological process is the gene described in this evidence involved in? | double-strand break repair via homologous recombination | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04465","source_qa_id":"medium_divergent_branch_00457","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"RNF168 interacts with multiple genes. One interaction is supported by evidence stating: 'We show ... | |
medium_divergent_branch_04466 | The gene HTT is known to interact with multiple proteins. One specific interaction partner is a protein that is preferentially expressed in the brain and testis, selectively binds to the huntingtin exon 1 protein (HDex1p) containing a pathological glutamine repeat, and promotes the formation of insoluble polyglutamine-... | Endophilin-A3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04466","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene HTT is known to interact with multiple proteins. One specific interaction partner is a protein that is preferentially expressed in the brain... | |
medium_divergent_branch_04467 | TNPO1 interacts with multiple proteins. One interaction is supported by evidence stating that SDS-PAGE and Western blot tests confirmed the recombinant purified protein coded by a 0.6 kb fragment of a specific cDNA could interact with transportin in vitro. Which protein corresponds to this specific interaction evidence... | RANBP2-like and GRIP domain-containing protein 5/6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04467","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TNPO1 interacts with multiple proteins. One interaction is supported by evidence stating that SDS-PAGE and Western blot tests confirmed the recombina... | |
medium_divergent_branch_04468 | The gene NEFL interacts with multiple proteins. One interaction is supported by evidence stating: 'The amino-terminal regulatory region of a protein kinase was shown to associate with the head-rod domains of other subunits of neurofilament (neurofilament proteins M and H) as well as neurofilament L protein in yeast cel... | Serine/threonine-protein kinase N1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04468","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene NEFL interacts with multiple proteins. One interaction is supported by evidence stating: 'The amino-terminal regulatory region of a protein ... | |
medium_divergent_branch_04469 | BRAF interacts with multiple proteins. One specific interaction is described by the following evidence: 'We report that MAPK activation induces Sprouty2 phosphorylation on six serine residues, which reduced Sprouty2 association with wild-type B-Raf.' Which protein is encoded by the gene corresponding to the interacting... | Protein sprouty homolog 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04469","source_qa_id":"medium_divergent_branch_07136","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"BRAF interacts with multiple proteins. One specific interaction is described by the following evi... | |
medium_divergent_branch_04470 | SFPQ interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we demonstrate a direct interaction between topoisomerase I and pyrimidine tract binding protein-associated splicing factor (PSF), a cofactor of RNA splicing, which forms heterodimers with its smaller homolog, the nuclear RNA-b... | adult medulloblastoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04470","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SFPQ interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we demonstrate a direct interaction between topoisomeras... | |
medium_divergent_branch_04471 | NUTF2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Previous studies have shown that immobilized recombinant [protein encoded by NUP62] can bind the cytosolic nuclear import factor NTF2 and thereby deplete transport activity from cytosol.' Which protein, encoded by the gene connec... | Nuclear pore glycoprotein p62 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04471","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NUTF2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Previous studies have shown that immobilized recombinant [... | |
medium_divergent_branch_04472 | ROCK2 is associated with multiple biological processes. One association is supported by evidence that depletion of ROCK2 leads to increased keratinocyte adhesion to fibronectin and inhibits terminal differentiation. Which biological process, connected to the process supported by this evidence, is linked via a 'regulate... | keratinocyte differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04472","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ROCK2 is associated with multiple biological processes. One association is supported by evidence that depletion of ROCK2 leads to increased keratinoc... | |
medium_divergent_branch_04473 | BRAP interacts with multiple genes. One specific interaction involves BRCA1-associated protein 2 binding to a partner that inhibits the ERK signal transduction cascade. Which disease is associated with this specific partner gene? | squamous cell carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04473","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BRAP interacts with multiple genes. One specific interaction involves BRCA1-associated protein 2 binding to a partner that inhibits the ERK signal tr... | |
medium_divergent_branch_04474 | The gene TBC1D1 is enriched in multiple cell types. One specific cell type shows a mean expression of 38.84 TPM, a z-score of 1.77, and a fold enrichment of 3.19 for this gene. Which cell type does this specific cell develop from? | classical monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04474","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TBC1D1 is enriched in multiple cell types. One specific cell type shows a mean expression of 38.84 TPM, a z-score of 1.77, and a fold enrich... | |
medium_divergent_branch_04475 | The gene ODC1 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 13.31 TPM, a z-score of 1.83, and a fold enrichment of 3.62. Which cell type is the parent class (is_a) of the cell type associated with these specific statistics? | dendritic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04475","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ODC1 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 13.31 TPM, a z... | |
medium_divergent_branch_04476 | Somatic hypermutation of immunoglobulin genes yields multiple distinct B cell populations. One such population is characterized by a germinal center B cell phenotype that is CD77-negative, IgD-negative, and CD38-positive, having undergone somatic mutation of the B cell receptor. Which cell type develops into this speci... | Bm3-delta B cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04476","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Somatic hypermutation of immunoglobulin genes yields multiple distinct B cell populations. One such population is characterized by a germinal center ... | |
medium_divergent_branch_04478 | The gene EED interacts with multiple histone H3 variants. One specific interaction is supported by evidence stating: 'We also show that a closely related Drosophila melanogaster paralog of ESC, ESC-like (ESCL), and the mammalian homolog of ESC, EED, also interact with histone H3 via their N termini, indicating that the... | squamous cell lung carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04478","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene EED interacts with multiple histone H3 variants. One specific interaction is supported by evidence stating: 'We also show that a closely rel... | |
medium_divergent_branch_04479 | The gene AGAP2 is known to interact with several partners. One specific interaction partner is described by the following evidence: 'Moreover, AMPK directly phosphorylates PIKE-A Ser-351 and Ser-377, which become accessible for the interaction with 14-3-3β, and in turn stimulates nuclear translocation of PIKE-A.' Ident... | hypoglycemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04479","source_qa_id":"medium_divergent_branch_06785","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene AGAP2 is known to interact with several partners. One specific interaction partner is de... | |
medium_divergent_branch_04480 | FMR1 interacts with multiple genes. Evidence indicates that NSP3 binding to FMRPs disrupts their interaction with a specific stress granule component through direct competition with a peptide motif in that component, thereby preventing FMRP incorporation into stress granules. Which disease is associated with this speci... | neurodevelopmental disorder with impaired language, behavioral abnormalities, and dysmorphic facies | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04480","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FMR1 interacts with multiple genes. Evidence indicates that NSP3 binding to FMRPs disrupts their interaction with a specific stress granule component... | |
medium_divergent_branch_04481 | MYH9 interacts with multiple proteins. One of these interaction partners is described in mechanistic experiments where its binding to MYH9 inhibits its own ubiquitination and degradation through the recruitment of USP14, and this partner is noted as a potential promoter of tumor proliferation. Which protein is encoded ... | Nucleosome assembly protein 1-like 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04481","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MYH9 interacts with multiple proteins. One of these interaction partners is described in mechanistic experiments where its binding to MYH9 inhibits i... | |
medium_divergent_branch_04482 | FBP1 interacts with multiple genes. One of these interacting partners is a ubiquitin carboxyl-terminal hydrolase that binds to FBP1 and induces its deubiquitination, thereby preventing FBP1 from translocating to the nucleus. Which disease is associated with this specific interacting gene through genomic alterations? | intellectual disability | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04482","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBP1 interacts with multiple genes. One of these interacting partners is a ubiquitin carboxyl-terminal hydrolase that binds to FBP1 and induces its d... | |
medium_divergent_branch_04483 | The gene POLR2E interacts with multiple proteins. One specific interaction is described as direct and mediated by the RPB1 subunit of RNA polymerase II. Which protein product is encoded by the gene involved in this specific interaction? | ATP-dependent DNA helicase Q5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04483","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene POLR2E interacts with multiple proteins. One specific interaction is described as direct and mediated by the RPB1 subunit of RNA polymerase ... | |
medium_divergent_branch_04484 | HAND2 is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence that mutant mice overexpressing HAND2 in otherwise healthy heart muscle cells developed pathological hypertrophy. Which biological process is positively regulated by the specific ... | cardiac muscle hypertrophy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04484","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HAND2 is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence that mut... | |
medium_divergent_branch_04485 | SORCS1 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'Searching for other VPS10-domain proteins in the database revealed three new putative human neuropeptide receptors. The new receptors were designated SorCS1, SorCS2 and SorC... | G protein-coupled peptide receptor activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04485","source_qa_id":"medium_divergent_branch_02897","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"SORCS1 is associated with multiple molecular functions via the 'enables' relationship. One specif... | |
medium_divergent_branch_04487 | MAD1L1 interacts with multiple proteins. Evidence for one specific interaction states: 'Complementary proteomic and cell biological analysis demonstrate that the spindle checkpoint protein MAD1 is one of the major components of the target protein complexes, and that the target protein is recruited to unattached kinetoc... | G2/mitotic-specific cyclin-B1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04487","source_qa_id":"medium_divergent_branch_06993","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"MAD1L1 interacts with multiple proteins. Evidence for one specific interaction states: 'Complemen... | |
medium_divergent_branch_04488 | LIPE (HSL) interacts with multiple perilipin family members. One specific interaction is supported by evidence stating that HSL closely, if not directly, interacts with a perilipin family member, as indicated by fluorescence resonance energy transfer (FRET) and bimolecular fluorescence complementation (BiFC) experiment... | Perilipin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04488","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LIPE (HSL) interacts with multiple perilipin family members. One specific interaction is supported by evidence stating that HSL closely, if not direc... | |
medium_divergent_branch_04491 | The gene TMEM205 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 177.30 TPM, a z-score of 1.62, and a fold enrichment of 2.35. Which cell type corresponds to this specific expression profile, and what is its immediate parent cell class in the hier... | dendritic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04491","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TMEM205 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 177.30 TPM,... | |
medium_divergent_branch_04492 | CKS1B interacts with multiple proteins. One specific interaction is supported by evidence stating: 'It has been shown previously that a direct interaction between Cks1 and Skp2 is required for p27(Kip1) degradation.' Which disease is associated with this interaction partner? | kidney cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04492","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CKS1B interacts with multiple proteins. One specific interaction is supported by evidence stating: 'It has been shown previously that a direct intera... | |
medium_divergent_branch_04493 | ZEB1 interacts with multiple proteins. One of these interaction partners functions as an adaptor that specifically recognizes the N-terminal zinc finger domain of ZEB1 and triggers its degradation via the ubiquitin-proteasome pathway. Which protein is this interaction partner? | DDB1- and CUL4-associated factor 15 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04493","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZEB1 interacts with multiple proteins. One of these interaction partners functions as an adaptor that specifically recognizes the N-terminal zinc fin... | |
medium_divergent_branch_04494 | The biological process 'regulation of DNA metabolic process' is defined as any process that modulates the frequency, rate, or extent of the chemical reactions and pathways involving DNA. This process is a subtype of a broader regulatory category. Which biological process is directly regulated by this broader category? | macromolecule metabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04494","source_qa_id":"medium_divergent_branch_05407","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'regulation of DNA metabolic process' is defined as any process that modul... | |
medium_divergent_branch_04495 | MAP3K2 interacts with multiple genes. One specific interaction is supported by evidence showing that the expression of JNK1, a MAP2K family member, and MEKK2 significantly augmented the coprecipitation of MEKK2-MAP2K family member, MEKK2-JNK1, and MAP2K family member-JNK1, indicating a synergistic interaction among the... | colon adenocarcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04495","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP3K2 interacts with multiple genes. One specific interaction is supported by evidence showing that the expression of JNK1, a MAP2K family member, a... | |
medium_divergent_branch_04496 | The Aryl hydrocarbon receptor (AHR) interacts with multiple genes. One specific interaction is supported by evidence stating that both coimmunoprecipitation and mammalian two-hybrid assays demonstrate that TCDD induces the interaction of AHR with the estrogen receptor alpha, regardless of the presence or absence of est... | transient ischemic attack | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04496","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The Aryl hydrocarbon receptor (AHR) interacts with multiple genes. One specific interaction is supported by evidence stating that both coimmunoprecip... | |
medium_divergent_branch_04498 | PTK2 interacts with multiple proteins. One of these interaction partners is reported to associate with Fak upon thrombin stimulation, as demonstrated by co-immunoprecipitation. Which protein is encoded by the gene corresponding to this interaction partner? | Tyrosine-protein kinase SYK | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04498","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PTK2 interacts with multiple proteins. One of these interaction partners is reported to associate with Fak upon thrombin stimulation, as demonstrated... | |
medium_divergent_branch_04500 | The HTT gene interacts with multiple partners. One specific interaction is supported by evidence stating: 'Using the yeast two-hybrid system, we have identified a human ubiquitin-conjugating enzyme (hE2-25K) as a protein that interacts with the gene product for Huntington disease (HD) (Huntingtin).' Which protein is en... | Ubiquitin-conjugating enzyme E2 K | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04500","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The HTT gene interacts with multiple partners. One specific interaction is supported by evidence stating: 'Using the yeast two-hybrid system, we have... | |
medium_divergent_branch_04501 | LRP1 is enriched in multiple cell types. One of these cell types shows a mean expression of 5.35 TPM, a z-score of 1.61, and a fold enrichment of 3.66. Which cell type does this specific LRP1-enriched cell develop from? | intermediate monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04501","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LRP1 is enriched in multiple cell types. One of these cell types shows a mean expression of 5.35 TPM, a z-score of 1.61, and a fold enrichment of 3.6... | |
medium_divergent_branch_04502 | CSNK1E interacts with multiple genes. One of these interaction partners was experimentally shown to interact with full-length Ckidelta, the isolated Ckidelta catalytic domain, Ckigamma2, -gamma3, and -epsilon in yeast two-hybrid assays, and to bind Ckidelta and -epsilon in pulldown assays, but not with Ckialpha. Which ... | negative regulation of protein kinase activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04502","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CSNK1E interacts with multiple genes. One of these interaction partners was experimentally shown to interact with full-length Ckidelta, the isolated ... | |
medium_divergent_branch_04503 | KDM2B interacts with multiple proteins. One interaction partner is a component of a variant PRC1 complex that also contains the BCL6 co-repressor BCOR and the histone demethylase KDM2B. Which protein is encoded by the gene corresponding to this interaction partner? | Polycomb group RING finger protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04503","source_qa_id":"medium_divergent_branch_06481","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"KDM2B interacts with multiple proteins. One interaction partner is a component of a variant PRC1 ... | |
medium_divergent_branch_04504 | HPD interacts with multiple proteins. One interaction is characterized by the finding that the molecular chaperone TTC36, which is highly expressed in the liver, associates with HPD and reduces the binding of a specific protein kinase to HPD, thereby inhibiting the kinase-mediated phosphorylation of HPD at threonine 38... | Serine/threonine-protein kinase 33 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04504","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HPD interacts with multiple proteins. One interaction is characterized by the finding that the molecular chaperone TTC36, which is highly expressed i... | |
medium_divergent_branch_04505 | KIF5B interacts with multiple genes. One interaction is supported by evidence stating: 'This screen initially identified synaptosome-associated protein of 25 kDa as a kinesin-binding protein.' Which disease is connected to this interaction partner through a biomarker relationship? | epilepsy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04505","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KIF5B interacts with multiple genes. One interaction is supported by evidence stating: 'This screen initially identified synaptosome-associated prote... | |
medium_divergent_branch_04506 | CFL1 interacts with multiple genes. One interaction is supported by evidence stating: 'We showed here that Hsp105alpha interacted with several cellular proteins, such as cofilin, dynein light chain 2A, alpha-adducin, ubiquitin activating enzyme E1, phosphoglycerate kinase 1, and platelet-activating factor acethylhydrol... | SCARF1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04506","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CFL1 interacts with multiple genes. One interaction is supported by evidence stating: 'We showed here that Hsp105alpha interacted with several cellul... | |
medium_divergent_branch_04507 | ATF7IP interacts with multiple proteins. One interaction is supported by evidence stating: 'Immunoprecipitation and in vitro binding analyses reveal that both MCAF proteins interact with MBD1, the shared protein, and Sp1 via two evolutionarily conserved distinct domains.' Which protein product is encoded by the gene id... | Histone-lysine N-methyltransferase SETDB1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04507","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATF7IP interacts with multiple proteins. One interaction is supported by evidence stating: 'Immunoprecipitation and in vitro binding analyses reveal ... | |
medium_divergent_branch_04508 | GLMN interacts with multiple proteins. One of these interaction partners is known to interact specifically with the inactive form of the HGF receptor (such as a kinase-defective or dephosphorylated wild-type receptor). Which protein is encoded by the gene corresponding to this specific interaction partner? | Hepatocyte growth factor receptor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04508","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GLMN interacts with multiple proteins. One of these interaction partners is known to interact specifically with the inactive form of the HGF receptor... | |
medium_divergent_branch_04509 | mmu-miR-155-5p regulates multiple cell types. One of these targets is supported by evidence stating that miR-155 functions in the hematopoietic compartment to promote the development of inflammatory cells, specifically including T helper 17 cells. Which cell type, connected to mmu-miR-155-5p via a 'regulates' relations... | CD4-positive helper T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04509","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"mmu-miR-155-5p regulates multiple cell types. One of these targets is supported by evidence stating that miR-155 functions in the hematopoietic compa... | |
medium_divergent_branch_04510 | The gene HELLS interacts with multiple partners. One specific interaction involves a partner that stabilizes HELLS via deubiquitination; this stabilization is disrupted by erastin treatment, leading to increased ubiquitination and degradation of HELLS. Which biological process is this specific interacting partner invol... | protein deubiquitination | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04510","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene HELLS interacts with multiple partners. One specific interaction involves a partner that stabilizes HELLS via deubiquitination; this stabili... | |
medium_divergent_branch_04511 | PARP1 is involved in multiple biological processes. One of these processes is supported by evidence that DNA-PK phosphorylates PARP1 on Thr594, facilitating its cytoplasmic translocation to inhibit antiviral immunity both in vitro and in vivo. Which biological process is negatively regulated by the specific PARP1-assoc... | innate immune response | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04511","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PARP1 is involved in multiple biological processes. One of these processes is supported by evidence that DNA-PK phosphorylates PARP1 on Thr594, facil... | |
medium_divergent_branch_04512 | HYOU1 interacts with multiple genes. One of these interaction partners is stabilized by ORP150 acting as a chaperone at the post-translational level. Which disease is associated with this specific interaction partner? | teratocarcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04512","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HYOU1 interacts with multiple genes. One of these interaction partners is stabilized by ORP150 acting as a chaperone at the post-translational level.... | |
medium_divergent_branch_04513 | CNTNAP2 interacts with multiple genes. One of these interacting partners is supported by evidence stating that a contactin family member, expressed in both neurons and glia, associates in cis with Caspr2 and in trans with itself. Which disease is associated with this specific interacting partner? | epilepsy, familial adult myoclonic, 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04513","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CNTNAP2 interacts with multiple genes. One of these interacting partners is supported by evidence stating that a contactin family member, expressed i... | |
medium_divergent_branch_04514 | NCAPD3 interacts with multiple proteins. One interaction involves a kinase that localizes to chromosome axes by binding to the CAP-D3 subunit, a process dependent on the phosphorylation of Thr 1415 of CAP-D3 by Cdk1. This kinase is required to hyperphosphorylate the condensin II complex. Which cell type is enriched for... | regulatory T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04514","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NCAPD3 interacts with multiple proteins. One interaction involves a kinase that localizes to chromosome axes by binding to the CAP-D3 subunit, a proc... | |
medium_divergent_branch_04515 | hsa-miR-142-3p regulates more than one cell type. Evidence for one of these regulatory connections notes that similar effects were observed in bone marrow-derived cells obtained from miR-142-3p-deficient mice. Which cell type, connected to hsa-miR-142-3p via the 'regulates' relation, is the subject of this evidence? Id... | mast cell progenitor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04515","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"hsa-miR-142-3p regulates more than one cell type. Evidence for one of these regulatory connections notes that similar effects were observed in bone m... | |
medium_divergent_branch_04516 | MAPKAP1 interacts with multiple proteins. One interaction partner is described in a study reporting that widely expressed isoforms of unstudied proteins termed Protor-1 and Protor-2 interact with this partner and are components of the mTORC2 complex. Which disease is associated with this interaction partner as a biomar... | pediatric lymphoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04516","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAPKAP1 interacts with multiple proteins. One interaction partner is described in a study reporting that widely expressed isoforms of unstudied prote... | |
medium_divergent_branch_04517 | USP25 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that USP25 directly interacted with tankyrases to promote their deubiquitination and stabilization.' Which protein, among those interacting with USP25, is described by this evidence? | Poly [ADP-ribose] polymerase tankyrase-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04517","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP25 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that USP25 directly interacted with tankyrases to... | |
medium_divergent_branch_04519 | PRKCE interacts with multiple proteins. One interaction is supported by evidence stating: 'Proteins coimmunoprecipitating with protein kinase C (PKC) epsilon in fibroblasts were identified through matrix-assisted laser desorption/ionisation time of flight mass spectrometry (MALDI TOF m/s). This method identified myosin... | Actin, alpha skeletal muscle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04519","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRKCE interacts with multiple proteins. One interaction is supported by evidence stating: 'Proteins coimmunoprecipitating with protein kinase C (PKC)... | |
medium_divergent_branch_04521 | The DKC1 gene interacts with multiple partners. One specific partner is characterized by evidence showing that in HeLa cells, it associates with dyskerin, hNop10, box H/ACA scaRNAs, snoRNAs, and hTR. Which protein is encoded by this specific interacting gene? | H/ACA ribonucleoprotein complex non-core subunit NAF1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04521","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The DKC1 gene interacts with multiple partners. One specific partner is characterized by evidence showing that in HeLa cells, it associates with dysk... | |
medium_divergent_branch_04522 | The ethmoid bone is classified as a type of anatomy. Evidence for one of these classifications describes a bone in the skull that separates the nasal cavity from the brain, located at the roof of the nose between the two orbits. This cubical bone is lightweight due to a spongy construction and is one of the bones that ... | facial skeleton | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04522","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The ethmoid bone is classified as a type of anatomy. Evidence for one of these classifications describes a bone in the skull that separates the nasal... | |
medium_divergent_branch_04523 | The gene CBL interacts with multiple partners. One interaction is supported by evidence stating: 'Our studies also reveal that Cbl, a ubiquitously expressed cytoplasmic adaptor protein, is responsible for the rapid degradation of TRAIL receptors; Cbl binds to them and induces monoubiquitination of these receptors concu... | Tumor necrosis factor receptor superfamily member 10B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04523","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CBL interacts with multiple partners. One interaction is supported by evidence stating: 'Our studies also reveal that Cbl, a ubiquitously ex... | |
medium_divergent_branch_04524 | RIPK1 interacts with multiple proteins. One specific interaction is supported by evidence showing that a specific interacting protein can be co-immunoprecipitated with RIP, TRAF2, and TNFR1 in mammalian cells. Which disease is associated with the gene encoding this interacting protein through genomic alterations? | heart failure | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04524","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RIPK1 interacts with multiple proteins. One specific interaction is supported by evidence showing that a specific interacting protein can be co-immun... |
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