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medium_divergent_branch_04525 | PTPN6 interacts with multiple proteins. One interaction is supported by evidence stating: 'We report that Tyk-2 forms stable complexes with the SH2-containing hematopoietic cell phosphatase (HCP) in several hematopoietic cell lines in vivo.' Which protein, connected to PTPN6 via this interaction, is the subject of the ... | Non-receptor tyrosine-protein kinase TYK2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04525","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PTPN6 interacts with multiple proteins. One interaction is supported by evidence stating: 'We report that Tyk-2 forms stable complexes with the SH2-c... | |
medium_divergent_branch_04526 | PDIA3 interacts with multiple proteins. One interaction is supported by evidence stating: 'We find PDI to be the main substrate of Ero1α, and mixed-disulphide complexes of Ero1 primarily form with PDI, to a lesser extent with the PDI-family members ERp57 and ERp72, but are not detectable with another homologue TMX3.' W... | ERO1-like protein alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04526","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PDIA3 interacts with multiple proteins. One interaction is supported by evidence stating: 'We find PDI to be the main substrate of Ero1α, and mixed-d... | |
medium_divergent_branch_04527 | AP2B1 interacts with multiple genes. One of these interacting partners is an RNA-binding ubiquitin E3 ligase that exists in three variants (referred to as variant-1, variant-2, and variant-3) and has been shown to interact with the adaptor-related protein complex 2 (AP-2), a cargo adaptor in clathrin-mediated endocytos... | autoimmune disorder of the nervous system | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04527","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AP2B1 interacts with multiple genes. One of these interacting partners is an RNA-binding ubiquitin E3 ligase that exists in three variants (referred ... | |
medium_divergent_branch_04528 | CUL4B interacts with multiple proteins. One of these interaction partners is reported to bind to several E3 ubiquitin ligases, including CUL4B, but does not bind to components of the NuA4 complex, such as MRGBP (which binds to MORF4L1). Which protein is encoded by the gene corresponding to this specific interaction par... | MORF4 family-associated protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04528","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CUL4B interacts with multiple proteins. One of these interaction partners is reported to bind to several E3 ubiquitin ligases, including CUL4B, but d... | |
medium_divergent_branch_04529 | The gene H2AX is known to interact with multiple proteins. One specific interaction partner is characterized by its ability to form complexes with phosphorylated H2AX. Which protein, encoded by the gene connected to H2AX via this interaction, is the subject of this description? | Mediator of DNA damage checkpoint protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04529","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene H2AX is known to interact with multiple proteins. One specific interaction partner is characterized by its ability to form complexes with ph... | |
medium_divergent_branch_04530 | NLRP3 interacts with multiple genes. One of these interacting partners is characterized by evidence stating that its phosphorylation attenuates its interaction with NLRP3, a process required for NLRP3 inflammasome activation. Which cell type is enriched in the gene encoding this specific interacting partner? | mucosal-associated invariant T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04530","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NLRP3 interacts with multiple genes. One of these interacting partners is characterized by evidence stating that its phosphorylation attenuates its i... | |
medium_divergent_branch_04532 | PAFAH1B1 (also known as LIS1) interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here, we reveal that cAMP-specific phosphodiesterases (PDE4s) directly bind PAFAH1B1 (also known as LIS1).' Identify the cell type in which the gene corresponding to this specific interaction is enri... | eosinophil | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04532","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PAFAH1B1 (also known as LIS1) interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here, we reveal that cAMP-sp... | |
medium_divergent_branch_04533 | CHEK1 interacts with multiple genes. One of these interaction partners is a dual-specificity protein phosphatase that, along with Cdc25A and Cdc25C, controls cell cycle transitions by dephosphorylating cyclin-dependent kinases. In vitro evidence shows Chk1 binds to and phosphorylates this specific phosphatase. Which pr... | M-phase inducer phosphatase 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04533","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CHEK1 interacts with multiple genes. One of these interaction partners is a dual-specificity protein phosphatase that, along with Cdc25A and Cdc25C, ... | |
medium_divergent_branch_04534 | Orthohepevirus A downregulates multiple genes. One such connection is supported by evidence showing a log2 fold change of -1.616 and an adjusted p-value of 0.04951. Which molecular function is enabled by the gene corresponding to this specific evidence? | protein binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04534","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Orthohepevirus A downregulates multiple genes. One such connection is supported by evidence showing a log2 fold change of -1.616 and an adjusted p-va... | |
medium_divergent_branch_04536 | KDM4B interacts with multiple proteins. One interaction involves a complex where Skp1, Cullin1, and an F-box-containing protein ubiquitylate KDM4B when it is complexed with tamoxifen-bound estrogen receptor (ER), leading to the release of steroid receptor coactivator (SRC). Which protein, encoded by the gene interactin... | F-box only protein 22 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04536","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KDM4B interacts with multiple proteins. One interaction involves a complex where Skp1, Cullin1, and an F-box-containing protein ubiquitylate KDM4B wh... | |
medium_divergent_branch_04537 | DNAH5 is associated with multiple biological processes. One association is supported by evidence showing that in patients with Primary Ciliary Dyskinesia (PCD) carrying DNAH5 or DNAI1 mutations, the protein is absent from the respiratory ciliary axoneme and accumulates at microtubule-organizing centers. Which biologica... | axonemal dynein complex assembly | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04537","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DNAH5 is associated with multiple biological processes. One association is supported by evidence showing that in patients with Primary Ciliary Dyskin... | |
medium_divergent_branch_04538 | Granzyme A (GZMA) is associated with multiple biological processes. One association is supported by evidence stating that GZMA may block cellular repair and force apoptosis. Which biological process, defined as a parent term of the process linked by this specific evidence, is connected to that process via an 'is a' rel... | programmed cell death | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04538","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Granzyme A (GZMA) is associated with multiple biological processes. One association is supported by evidence stating that GZMA may block cellular rep... | |
medium_divergent_branch_04539 | The gene PLA2G1B is associated with multiple biological processes. One association is supported by evidence that sPLA2 IB induces podocyte apoptosis in a time- and concentration-dependent manner. Which biological process is positively regulated by the specific process linked to this evidence? | podocyte apoptotic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04539","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PLA2G1B is associated with multiple biological processes. One association is supported by evidence that sPLA2 IB induces podocyte apoptosis ... | |
medium_divergent_branch_04540 | PARP2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Tandem affinity purification reveals that Iduna binds to a number of proteins that are either PARsylated or bind PAR including PAR polymerase-1, 2, nucleolin, DNA ligase III, KU70, KU86, XRCC1, and histones.' Which protein, conne... | E3 ubiquitin-protein ligase RNF146 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04540","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PARP2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Tandem affinity purification reveals that Iduna binds to a... | |
medium_divergent_branch_04541 | LRP1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'To quantify the interaction between a protein encoded by the gene connected to LRP1 via this specific interaction and phosphorylated forms of the LRP1 intracellular domain, we utilized an ELISA with purified recombinant p... | Tyrosine-protein phosphatase non-receptor type 11 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04541","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LRP1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'To quantify the interaction between a protein enco... | |
medium_divergent_branch_04542 | TRIM38 interacts with multiple genes. One specific interaction is characterized by the mechanism where TRIM38 interacts with heat shock protein family A member 5 and stabilizes it via K63-dependent ubiquitination. Which disease is connected to this specific interacting gene through genomic alterations? | Parkinson disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04542","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM38 interacts with multiple genes. One specific interaction is characterized by the mechanism where TRIM38 interacts with heat shock protein famil... | |
medium_divergent_branch_04543 | SFRP1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'Furthermore, we demonstrated that SFRP1 and SFRP2 enhance the expression of the epithelial marker E-cadherin, through inhibition of the expression of SLUG, TWIST and SNAIL, three transcription factors inv... | epithelial to mesenchymal transition | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04543","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SFRP1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'Furthermore, we demonstrated that... | |
medium_divergent_branch_04545 | NOTCH1 interacts with multiple genes. One of these interaction partners is known to directly interact with the NOTCH1 intracellular domain (NICD) and phosphorylate it, thereby decreasing proteasomal protein degradation mediated by F-box and WD repeat domain-containing 7 (Fbw7). Which cell type is enriched for this spec... | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04545","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NOTCH1 interacts with multiple genes. One of these interaction partners is known to directly interact with the NOTCH1 intracellular domain (NICD) and... | |
medium_divergent_branch_04547 | PAX8 is associated with multiple biological processes. One association is supported by evidence stating: 'In situ hybridization to sections of human embryonic and fetal kidney showed expression of PAX8 in condensed mesenchyme, comma-shaped and S-shaped bodies.' Which biological process is connected to this specific PAX... | metanephric nephron morphogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04547","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PAX8 is associated with multiple biological processes. One association is supported by evidence stating: 'In situ hybridization to sections of human ... | |
medium_divergent_branch_04548 | RNF19A interacts with multiple genes. One of these interactions is characterized by the mechanism: 'Mechanistically, RNF19A could directly interact with this partner and promote its ubiquitination and degradation.' Which cell type is enriched in the gene that fits this mechanistic description? | eosinophil | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04548","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF19A interacts with multiple genes. One of these interactions is characterized by the mechanism: 'Mechanistically, RNF19A could directly interact w... | |
medium_divergent_branch_04549 | The proximal straight tubule is anatomically associated with two distinct structures via a 'part of' relationship. One association is supported by the statement: 'The proximal straight tubule is the part of the descending limb that extends from the proximal convoluted tubule to the descending thin tubule.' Based on thi... | region of nephron tubule | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04549","source_qa_id":"medium_divergent_branch_06425","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The proximal straight tubule is anatomically associated with two distinct structures via a 'part ... | |
medium_divergent_branch_04550 | UBE2E3 interacts with multiple genes. One of these interaction partners is a protein that undergoes autoubiquitination catalyzed by Ube2d, Ube2e families, Ube2n/2v1, and Ube2w, and mediates the ubiquitination of EGFR and SYK when catalyzed by Ube2d2, Ube2e1, and Ube2n/2v1. Which disease is associated with this specific... | uniparental disomy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04550","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBE2E3 interacts with multiple genes. One of these interaction partners is a protein that undergoes autoubiquitination catalyzed by Ube2d, Ube2e fami... | |
medium_divergent_branch_04551 | SUMO2 interacts with multiple proteins. One of these interactions is supported by evidence stating: 'Here, we show that the interacting partner binds SUMO-2/3 chains via SUMO-interacting motifs (SIMs).' Identify the protein encoded by the gene corresponding to this interacting partner. | Structure-specific endonuclease subunit SLX4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04551","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SUMO2 interacts with multiple proteins. One of these interactions is supported by evidence stating: 'Here, we show that the interacting partner binds... | |
medium_divergent_branch_04552 | The p75 neurotrophin receptor (NGFR) interacts with multiple proteins. One specific interaction is described by the evidence: 'In addition, necdin and MAGE-G1 interacted with the p75 neurotrophin receptor via its distinct intracellular domains.' Based on this description, identify the gene among the NGFR interactors th... | lung disease, immunodeficiency, and chromosome breakage syndrome; | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04552","source_qa_id":"medium_divergent_branch_06424","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The p75 neurotrophin receptor (NGFR) interacts with multiple proteins. One specific interaction i... | |
medium_divergent_branch_04553 | NDNF is associated with multiple biological processes. One association is supported by evidence that NDNF promoted migration and growth and elicited neurite outgrowth of mouse hippocampal neurons in culture. Which biological process, connected to the process supported by this evidence via a 'part of' relationship, is t... | generation of neurons | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04553","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NDNF is associated with multiple biological processes. One association is supported by evidence that NDNF promoted migration and growth and elicited ... | |
medium_divergent_branch_04554 | CCDC22 interacts with multiple proteins. One of these interaction partners is described in a study stating: 'Here we demonstrate that all COMMD proteins bind to CCDC22, a factor recently implicated in X-linked intellectual disability (XLID).' Which protein, encoded by the gene connected to CCDC22 via this specific inte... | COMM domain-containing protein 9 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04554","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CCDC22 interacts with multiple proteins. One of these interaction partners is described in a study stating: 'Here we demonstrate that all COMMD prote... | |
medium_divergent_branch_04555 | MIR16-1 is associated with multiple biological processes. One association is supported by evidence stating: 'Collectively, these data strongly suggest that miR-16 regulates placental angiogenesis and development by targeting VEGF expression and is involved in the pathogenesis of RSA.' Identify the biological process th... | placenta blood vessel development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04555","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR16-1 is associated with multiple biological processes. One association is supported by evidence stating: 'Collectively, these data strongly sugges... | |
medium_divergent_branch_04556 | MIS18A interacts with multiple proteins. One interaction is supported by evidence stating: 'We report here that a specific arrangement of Yippee domains in a human Mis18α:Mis18β 4:2 hexamer binds two copies of M18BP1 through M18BP1's 140 N-terminal residues.' Which protein, among those interacting with MIS18A, is encod... | Protein Mis18-beta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04556","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIS18A interacts with multiple proteins. One interaction is supported by evidence stating: 'We report here that a specific arrangement of Yippee doma... | |
medium_divergent_branch_04557 | ELL2 interacts with multiple genes. For one of these interacting partners, experimental evidence indicates that Siah1 is unable to access and ubiquitinate ELL2 when it is bound to this partner. Which disease is associated with this specific interacting gene through genomic alterations? | cognitive impairment - coarse facies - heart defects - obesity - pulmonary involvement - short stature - skeletal dysplasia syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04557","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ELL2 interacts with multiple genes. For one of these interacting partners, experimental evidence indicates that Siah1 is unable to access and ubiquit... | |
medium_divergent_branch_04558 | The gene TMPO is reported to interact with multiple partners. One specific interaction is supported by evidence stating: 'We found that amino acids in the region of residues 78-258 of the lamin B1 rod domain directly bound with LAP2.' Which protein is encoded by the gene that corresponds to this specific interaction pa... | Lamin-B2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04558","source_qa_id":"medium_divergent_branch_06016","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene TMPO is reported to interact with multiple partners. One specific interaction is support... | |
medium_divergent_branch_04559 | USP24 interacts with multiple genes. One specific interaction is supported by evidence stating that a co-immunoprecipitation assay validated the mutual effect between USP24 and the partner gene. Which cell type is the partner gene enriched in? | eosinophil | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04559","source_qa_id":"medium_divergent_branch_02099","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"USP24 interacts with multiple genes. One specific interaction is supported by evidence stating th... | |
medium_divergent_branch_04560 | SAMHD1 interacts with multiple proteins. One interaction is characterized by the partner protein stabilizing SAMHD1 through the inhibition of DCAF1-mediated ubiquitination and degradation. Which protein product is encoded by the gene corresponding to this specific interacting partner? | Non-POU domain-containing octamer-binding protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04560","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SAMHD1 interacts with multiple proteins. One interaction is characterized by the partner protein stabilizing SAMHD1 through the inhibition of DCAF1-m... | |
medium_divergent_branch_04561 | CDKN1B interacts with multiple genes. One specific interaction involves p27 binding to the target protein in the nucleus, mediated by the C-termini of both proteins and specifically involving box 4 of the target protein. Which disease is causally linked to this target gene? | rectum adenocarcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04561","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDKN1B interacts with multiple genes. One specific interaction involves p27 binding to the target protein in the nucleus, mediated by the C-termini o... | |
medium_divergent_branch_04562 | ARHGAP26 interacts with multiple proteins. One interaction is supported by evidence showing that Graf or Graf2 was co-immunoprecipitated with a protein kinase in COS-7 cells transiently transfected with Graf or Graf2 and that protein kinase expression constructs. Which protein, encoded by the gene involved in this spec... | Serine/threonine-protein kinase N3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04562","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARHGAP26 interacts with multiple proteins. One interaction is supported by evidence showing that Graf or Graf2 was co-immunoprecipitated with a prote... | |
medium_divergent_branch_04563 | VPS25 interacts with multiple proteins. One specific interaction is supported by evidence describing a complex with three lobes containing one copy each of VPS22 and the interacting partner, along with two copies of VPS25. Which protein corresponds to this interacting partner? | Vacuolar protein-sorting-associated protein 36 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04563","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VPS25 interacts with multiple proteins. One specific interaction is supported by evidence describing a complex with three lobes containing one copy e... | |
medium_divergent_branch_04564 | ATP2A1 interacts with multiple proteins. One of these interaction partners is reported to interact with SERCA and prevent the formation of the SERCA/PLN/SLN inhibitory complex. Which protein, encoded by the gene connected to ATP2A1 via this specific interaction, is being described? | Vacuole membrane protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04564","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATP2A1 interacts with multiple proteins. One of these interaction partners is reported to interact with SERCA and prevent the formation of the SERCA/... | |
medium_divergent_branch_04565 | NUDT8 is enriched in multiple cell types. One of these cell types shows a mean expression of 9.57 TPM, a z-score of 1.55, and a fold enrichment of 3.09. Which cell type is the developmental precursor of the cell type matching these expression statistics? | pro-NK cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04565","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NUDT8 is enriched in multiple cell types. One of these cell types shows a mean expression of 9.57 TPM, a z-score of 1.55, and a fold enrichment of 3.... | |
medium_divergent_branch_04567 | TRAF3IP2 interacts with multiple genes. One of these interactions is supported by evidence stating: 'The mutation, located in the SEFIR domain, abolished the homotypic interaction of ACT1 with IL-17 receptors, with no effect on homodimerization.' Which gene is connected to TRAF3IP2 through this specific interaction? | TRAF6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04567","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRAF3IP2 interacts with multiple genes. One of these interactions is supported by evidence stating: 'The mutation, located in the SEFIR domain, aboli... | |
medium_divergent_branch_04568 | PARP1 is involved in multiple biological processes. One such process involves the recruitment of KDM4D, a mechanism that is independent of the DDR sensor ATM but dependent on PARP1, which ADP-ribosylates KDM4D after DNA damage. Which broader biological process is this specific process a subtype of (is_a)? | regulation of localization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04568","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PARP1 is involved in multiple biological processes. One such process involves the recruitment of KDM4D, a mechanism that is independent of the DDR se... | |
medium_divergent_branch_04569 | KCNB1 interacts with multiple proteins. One specific interaction involves the formation of Kv2.1 clusters, which occurs when the Kv2.1 proximal restriction and clustering (PRC) domain binds to endoplasmic reticulum (ER)-resident proteins, including VAPB and the protein in question. Which protein is this? | Vesicle-associated membrane protein-associated protein A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04569","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KCNB1 interacts with multiple proteins. One specific interaction involves the formation of Kv2.1 clusters, which occurs when the Kv2.1 proximal restr... | |
medium_divergent_branch_04570 | PFKL interacts with multiple proteins. One specific interaction is characterized by a mechanism where the interacting partner directly binds PFKL and recruits the deubiquitinating enzyme USP39 to enhance PFKL protein stability, thereby promoting abnormal glycolysis in hepatocellular carcinoma (HCC) cells. Which protein... | Dynein axonemal assembly factor 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04570","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PFKL interacts with multiple proteins. One specific interaction is characterized by a mechanism where the interacting partner directly binds PFKL and... | |
medium_divergent_branch_04571 | The gene IKBKB is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'We report here that alphaPKC as well as the atypical PKCs bind to the IKKs in vitro and in vivo.' Based on this evidence, which protein product is encoded by the gene that binds to IKBKB? | Protein kinase C alpha type | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04571","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene IKBKB is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'We report here that alphaPKC ... | |
medium_divergent_branch_04572 | HSPA2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Protein-protein interaction assays revealed the stable interaction of the target protein and HSPA2 proteins in mature spermatozoa.' Which protein, connected to HSPA2 via this specific interaction evidence, is encoded by the gene ... | Large proline-rich protein BAG6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04572","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HSPA2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Protein-protein interaction assays revealed the stable int... | |
medium_divergent_branch_04573 | MIR145 is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence stating: 'Mir-145 is involved in M2 macrophage polarization by targeting IL-16 and enhancing IL-10 expression.' Identify the biological process linked to this specific associatio... | macrophage differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04573","source_qa_id":"medium_divergent_branch_06468","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"MIR145 is associated with multiple biological processes via the 'involved in' relationship. One s... | |
medium_divergent_branch_04574 | The gene AMOT interacts with multiple partners. One interaction partner is a kinase that phosphorylates the Angiomotin p130 isoform on a conserved HXRXXS motif downstream of GPCR signaling. Which protein is encoded by this interacting gene? | Serine/threonine-protein kinase LATS2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04574","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene AMOT interacts with multiple partners. One interaction partner is a kinase that phosphorylates the Angiomotin p130 isoform on a conserved HX... | |
medium_divergent_branch_04575 | FBXW8 interacts with multiple proteins. One interaction is supported by evidence stating that CUL7 assembles an SCF-ROC1-like E3 ubiquitin ligase complex consisting of the interacting partner, CUL7, the Fbx29 F-box protein, and ROC1. Which protein is this interacting partner? | S-phase kinase-associated protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04575","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBXW8 interacts with multiple proteins. One interaction is supported by evidence stating that CUL7 assembles an SCF-ROC1-like E3 ubiquitin ligase com... | |
medium_divergent_branch_04576 | MYO1C interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We report here that NM1 binds SNF2h with enhanced affinity upon impairment of the actin-binding function.' Which protein, connected to MYO1C via this interaction, is the gene that encodes the protein described in the evi... | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04576","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MYO1C interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We report here that NM1 binds SNF2h with enhanced... | |
medium_divergent_branch_04577 | GIGYF1 interacts with multiple genes. One of these interacting partners is characterized by harboring three proline-rich motifs that bind the GYF domain of GIGYF1, a feature similar to that of TTP. Which gene is this interacting partner? | EIF4E2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04577","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GIGYF1 interacts with multiple genes. One of these interacting partners is characterized by harboring three proline-rich motifs that bind the GYF dom... | |
medium_divergent_branch_04578 | The gene TRBV4-3 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 69.89 TPM, a z-score of 1.58, and a fold enrichment of 5.15. Which cell type, identified by this specific expression profile, is a subtype of mature alpha-beta T cells? | mature alpha-beta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04578","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TRBV4-3 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 69.89 TPM, a z-score o... | |
medium_divergent_branch_04579 | PRDX5 interacts with multiple genes. Evidence for one of these interactions states: 'We show that the [protein]-PRDX5 interaction, critical for mt redox homeostasis, can be perturbed by amyotrophic lateral sclerosis-linked [protein] allelic variants and establish a functional role for ND-linked factors coupled with IκB... | Superoxide dismutase [Cu-Zn] | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04579","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRDX5 interacts with multiple genes. Evidence for one of these interactions states: 'We show that the [protein]-PRDX5 interaction, critical for mt re... | |
medium_divergent_branch_04580 | The alpha-beta T cell receptor complex is found in high amounts on the plasma membrane of multiple thymocyte populations. One such population is characterized as a double-positive thymocyte undergoing positive selection, exhibiting high alpha-beta T cell receptor expression, CD69 positivity, and active downregulation o... | CD69-positive double-positive thymocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04580","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The alpha-beta T cell receptor complex is found in high amounts on the plasma membrane of multiple thymocyte populations. One such population is char... | |
medium_divergent_branch_04581 | MORC2 interacts with multiple genes. One of these interaction partners is known to be involved in a pathway where DNA-damaging chemotherapeutic agents and ionizing radiation stimulate the acetylation of MORC2 at lysine 767 (K767Ac) by enhancing the physical interaction between MORC2 and this partner. Which gene, among ... | THUMPD1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04581","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MORC2 interacts with multiple genes. One of these interaction partners is known to be involved in a pathway where DNA-damaging chemotherapeutic agent... | |
medium_divergent_branch_04582 | IKZF3 interacts with multiple proteins. One interaction is supported by evidence stating that repression is mediated through two independent domains at the N and C terminus of the protein, both of which can independently recruit the corepressors Mi-2beta, Sin3A, and Sin3B and the Class I histone deacetylases 1 and 2; t... | Histone deacetylase 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04582","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IKZF3 interacts with multiple proteins. One interaction is supported by evidence stating that repression is mediated through two independent domains ... | |
medium_divergent_branch_04583 | KIF1C interacts with multiple proteins. One interaction was identified using the ezrin domain of a protein-tyrosine phosphatase as bait in a yeast two-hybrid screen, which revealed a new kinesin-like protein. Which protein, encoded by the gene connected to KIF1C via this specific interaction evidence, is the subject of... | Tyrosine-protein phosphatase non-receptor type 21 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04583","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KIF1C interacts with multiple proteins. One interaction was identified using the ezrin domain of a protein-tyrosine phosphatase as bait in a yeast tw... | |
medium_divergent_branch_04584 | Cycloserine interacts with multiple substances. One specific interaction is characterized by the finding that D-cycloserine enhances rapid tolerance to motor incoordination caused by the interacting substance. Which disease is the interacting substance indicated for? | trigeminal neuralgia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04584","source_qa_id":"medium_divergent_branch_06069","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"Cycloserine interacts with multiple substances. One specific interaction is characterized by the ... | |
medium_divergent_branch_04585 | The liver is classified as a type of anatomy. One such classification describes an entity that secretes bile, metabolizes proteins, carbohydrates, and fats, synthesizes blood clotting factors and vitamin A, detoxifies poisons, stores glycogen, and breaks down worn-out erythrocytes. Which anatomical system is the liver ... | exocrine system | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04585","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The liver is classified as a type of anatomy. One such classification describes an entity that secretes bile, metabolizes proteins, carbohydrates, an... | |
medium_divergent_branch_04586 | PAK1 interacts with multiple proteins. One specific interaction is characterized by the following evidence: 'Using transient transfection, coimmunoprecipitation and glutathione S-transferase-pull down assays, we showed that a tyrosine kinase directly associates with PAK1 via its N-terminal pleckstrin homology domain an... | psoriasis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04586","source_qa_id":"medium_divergent_branch_03090","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"PAK1 interacts with multiple proteins. One specific interaction is characterized by the following... | |
medium_divergent_branch_04587 | USP53 interacts with multiple proteins. One interaction is supported by mass spectrometry evidence showing that the interacting partner promotes the proteasomal degradation of β-catenin. Which protein corresponds to this specific interaction partner? | F-box only protein 31 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04587","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP53 interacts with multiple proteins. One interaction is supported by mass spectrometry evidence showing that the interacting partner promotes the ... | |
medium_divergent_branch_04588 | The gene KSR2 interacts with multiple partners. One specific interaction is supported by evidence stating: 'We show that, similar to the known human KSR, hKSR-2 co-immunoprecipitates with many signaling components of the Ras/MAPK pathway, including Ras, Raf, MEK-1, and ERK-1/2.' Identify the protein encoded by the gene... | Dual specificity mitogen-activated protein kinase kinase 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04588","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene KSR2 interacts with multiple partners. One specific interaction is supported by evidence stating: 'We show that, similar to the known human ... | |
medium_divergent_branch_04589 | MIR146A is involved in multiple biological processes. One line of evidence states: 'Two differentially expressed miRNAs were found: miR146a and miR147b, which were associated with increased expression of genes related to the immune/inflammatory response.' Based on this evidence, which biological process is connected to... | gene expression | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04589","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR146A is involved in multiple biological processes. One line of evidence states: 'Two differentially expressed miRNAs were found: miR146a and miR14... | |
medium_divergent_branch_04590 | RBBP4 interacts with multiple genes. One of these interacting partners is noted to copurify with multiple constituents of the nucleosome remodeling and deacetylation (NuRD) complex, including CHD4, HDAC1, and RBBP4 itself. Which gene is connected to RBBP4 through the 'interacts with' relation? | CUL3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04590","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RBBP4 interacts with multiple genes. One of these interacting partners is noted to copurify with multiple constituents of the nucleosome remodeling a... | |
medium_divergent_branch_04591 | The gene RAN interacts with multiple proteins. One interaction is supported by evidence stating: 'In the nucleus, Ran GTP binds karyopherin-beta2 and dissociates the substrate.' Which protein is encoded by the gene that binds RAN in this specific context? | Transportin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04591","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene RAN interacts with multiple proteins. One interaction is supported by evidence stating: 'In the nucleus, Ran GTP binds karyopherin-beta2 and... | |
medium_divergent_branch_04593 | hsa-let-7i-5p regulates more than one cell type. Evidence for one of these regulatory connections states: 'In this study, we found that HIV-1 infection decreases the expression of let-7i in CD4(+) T cells by attenuating its promoter activity.' Which cell type is connected to the cell mentioned in this evidence through ... | mature alpha-beta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04593","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"hsa-let-7i-5p regulates more than one cell type. Evidence for one of these regulatory connections states: 'In this study, we found that HIV-1 infecti... | |
medium_divergent_branch_04595 | The gene PPM1F is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 26.84 TPM, a z-score of 1.64, and a fold enrichment of 3.71. Which cell type corresponds to this specific expression profile, and what is its immediate parent cell class in the hierarc... | monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04595","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PPM1F is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 26.84 TPM, a ... | |
medium_divergent_branch_04596 | The gene HIST1H3E interacts with multiple proteins. One of these interacting partners contains a PHD-Bromo region whose three-dimensional structure reveals a single functional unit for the combinatorial recognition of unmodified H3K4 (H3K4me0) and acetylated H3K23 (H3K23ac) within the same histone tail. Which protein i... | Transcription intermediary factor 1-alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04596","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene HIST1H3E interacts with multiple proteins. One of these interacting partners contains a PHD-Bromo region whose three-dimensional structure r... | |
medium_divergent_branch_04597 | NCOA4 interacts with multiple genes. One of these interacting partners binds directly to NCOA4 and is required for the lysosomal trafficking of ferritin under both basal and iron-depleted conditions. Which disease is associated with this specific interacting gene through genomic alterations? | oral cavity carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04597","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NCOA4 interacts with multiple genes. One of these interacting partners binds directly to NCOA4 and is required for the lysosomal trafficking of ferri... | |
medium_divergent_branch_04598 | ABCB1 interacts with multiple proteins. One interaction is supported by evidence showing that a serine/threonine-protein kinase directly interacted with and phosphorylated Pgp in intact cells and in vitro. Which protein is encoded by the gene corresponding to this interacting partner? | Serine/threonine-protein kinase pim-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04598","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ABCB1 interacts with multiple proteins. One interaction is supported by evidence showing that a serine/threonine-protein kinase directly interacted w... | |
medium_divergent_branch_04599 | GPNMB is associated with multiple biological processes. One association is supported by evidence stating that ectodomain shedding may serve as a novel mechanism by which GPNMB promotes angiogenesis in breast cancer. Which cell type is linked to this specific biological process via the 'enabled by cell' relationship? | secretory pericyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04599","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GPNMB is associated with multiple biological processes. One association is supported by evidence stating that ectodomain shedding may serve as a nove... | |
medium_divergent_branch_04600 | The gene EIF2B1 interacts with multiple other genes. One of these interacting partners is described by evidence stating that removal of either the N- or C-terminal conserved domains of the protein encoded by this partner leads to a significant loss of GEF activity and reduced or abolished interaction with the alpha-, g... | Translation initiation factor eIF2B subunit epsilon | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04600","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene EIF2B1 interacts with multiple other genes. One of these interacting partners is described by evidence stating that removal of either the N-... | |
medium_divergent_branch_04601 | CHEK2 interacts with multiple proteins. One interaction is supported by evidence stating: 'To identify new regulators of this kinase, we performed a yeast two-hybrid screen and found that Chk2 associated with the B' regulatory subunit of protein phosphatase PP2A.' Which protein, encoded by the gene connected to CHEK2 v... | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04601","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CHEK2 interacts with multiple proteins. One interaction is supported by evidence stating: 'To identify new regulators of this kinase, we performed a ... | |
medium_divergent_branch_04602 | SRSF9 interacts with multiple proteins. One interaction is supported by evidence stating: 'Interaction studies in yeast, in vitro protein interaction assays, and co-immunoprecipitations demonstrated that the protein encoded by NOL3 multimerizes and binds to the RS domain of SRp30c but not to other splicing factors test... | Nucleolar protein 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04602","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SRSF9 interacts with multiple proteins. One interaction is supported by evidence stating: 'Interaction studies in yeast, in vitro protein interaction... | |
medium_divergent_branch_04603 | The gene SLC25A43 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 7.85 TPM, a z-score of 1.55, and a fold enrichment of 3.03. Which cell type, connected to SLC25A43 via this specific evidence, is the subject of the 'develops from' relationship? | pro-NK cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04603","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene SLC25A43 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 7.85 TPM, ... | |
medium_divergent_branch_04604 | CYLD interacts with multiple proteins. One such interaction is supported by evidence stating: 'To dissect CYLD function we used a proteomics approach to identify CYLD interacting proteins and identified [the interacting protein], an ubiquitin ligase enzyme involved in Notch signalling, as a protein which interacts with... | E3 ubiquitin-protein ligase MIB2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04604","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CYLD interacts with multiple proteins. One such interaction is supported by evidence stating: 'To dissect CYLD function we used a proteomics approach... | |
medium_divergent_branch_04605 | SAP30 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we identify SAP30 as a novel component of the human histone deacetylase complex that includes Sin3, the histone deacetylases HDAC1 and HDAC2, histone binding proteins RbAp46 and RbAp48, as well as other polypeptides.' Which... | leukemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04605","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SAP30 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we identify SAP30 as a novel component of the human ... | |
medium_divergent_branch_04607 | TRIM50 interacts with multiple proteins. One of these interaction partners is a transcription factor that was identified as a novel ubiquitination target of TRIM50 through mass spectrometry and co-immunoprecipitation experiments. Which protein, encoded by the gene corresponding to this specific interaction partner, is ... | Junction plakoglobin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04607","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM50 interacts with multiple proteins. One of these interaction partners is a transcription factor that was identified as a novel ubiquitination ta... | |
medium_divergent_branch_04609 | FOXC1 is associated with multiple biological processes. One specific association is supported by evidence showing that knockdown of FOXC1 expression results in cytoskeleton modification and a decreased ability for cell proliferation, migration, and invasion. Which cell type is a participant in the biological process mo... | double-positive blast | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04609","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FOXC1 is associated with multiple biological processes. One specific association is supported by evidence showing that knockdown of FOXC1 expression ... | |
medium_divergent_branch_04610 | XIAP interacts with multiple genes. One interaction is supported by evidence stating: 'In this study, we found that XIAP, cIAP1 and cIAP2 not only directly bind to RIP1 and [REDACTED_GENE] but also to RIP3 and RIP4.' Which cell type is enriched in the gene connected to XIAP via this specific interaction? | eosinophil | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04610","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"XIAP interacts with multiple genes. One interaction is supported by evidence stating: 'In this study, we found that XIAP, cIAP1 and cIAP2 not only di... | |
medium_divergent_branch_04612 | Glomerular mesangial cells are a type of cell found within the kidney. Evidence indicates that the specific cell type in question is located among the glomerular capillaries in a renal corpuscle. Which anatomical structure is this cell type a part of? | renal glomerulus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04612","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Glomerular mesangial cells are a type of cell found within the kidney. Evidence indicates that the specific cell type in question is located among th... | |
medium_divergent_branch_04613 | NAP1L1 interacts with multiple proteins. Evidence for one of these interactions describes Cryo-EM structures of the interacting protein in complex with NAP1L1, revealing a malleable client recruitment interface that is autoinhibited by an intrinsically reactive UBC domain. Which protein, connected to NAP1L1 via an inte... | (E3-independent) E2 ubiquitin-conjugating enzyme | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04613","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NAP1L1 interacts with multiple proteins. Evidence for one of these interactions describes Cryo-EM structures of the interacting protein in complex wi... | |
medium_divergent_branch_04614 | SNAPC1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Immunoprecipitation studies confirm that the four PTF subunits originally found to copurify during conventional chromatography indeed form a tightly associated complex; they further show that the PTF so defined, including the ga... | snRNA-activating protein complex subunit 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04614","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SNAPC1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Immunoprecipitation studies confirm that the four PTF sub... | |
medium_divergent_branch_04615 | COMMD1 interacts with multiple genes. One of these interacting partners is distinguished by the following evidence: 'In contrast with COMMD1, COMMD6 does not bind to the inhibitor of NF-kappaB alpha subunit, indicating that both proteins inhibit NF-kappaB in an overlapping, but not completely similar, manner.' Which di... | nephritis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04615","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"COMMD1 interacts with multiple genes. One of these interacting partners is distinguished by the following evidence: 'In contrast with COMMD1, COMMD6 ... | |
medium_divergent_branch_04616 | FAM76B is associated with multiple biological processes. One association is supported by evidence stating: 'These results suggest that FAM76B inhibits M1 macrophage polarization.' Which biological process, connected to the process supported by this evidence via a 'negatively regulates' relationship, is the target of th... | macrophage activation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04616","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FAM76B is associated with multiple biological processes. One association is supported by evidence stating: 'These results suggest that FAM76B inhibit... | |
medium_divergent_branch_04617 | ETFRF1 is known to interact with multiple proteins. One specific interaction partner is described in the following evidence: 'We likewise discovered that LYRM5 interacts with and deflavinates the electron-transferring flavoprotein that shuttles electrons to coenzyme Q (CoQ).' Based on this description, which protein is... | Electron transfer flavoprotein subunit beta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04617","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ETFRF1 is known to interact with multiple proteins. One specific interaction partner is described in the following evidence: 'We likewise discovered ... | |
medium_divergent_branch_04618 | HSPA6 is associated with multiple molecular functions. One specific function is supported by evidence indicating that HSPA6 possesses intrinsic ATPase activity comparable to HSPA1A when stimulated by J-proteins. Which broader molecular function category is this specific activity a subclass of? | ribonucleoside triphosphate phosphatase activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04618","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HSPA6 is associated with multiple molecular functions. One specific function is supported by evidence indicating that HSPA6 possesses intrinsic ATPas... | |
medium_divergent_branch_04620 | USP19 interacts with multiple proteins. One specific interaction partner is described by the following evidence: 'Our study indicates that USP19 interacts with this protein and prevents polyubiquitination of this protein, subsequently extending the half-life of this protein.' What molecular function is enabled by this ... | phenylalanine 4-monooxygenase activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04620","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP19 interacts with multiple proteins. One specific interaction partner is described by the following evidence: 'Our study indicates that USP19 inte... | |
medium_divergent_branch_04621 | ASB9 interacts with multiple proteins. One interaction is supported by evidence stating: 'We determined the crystal structures of the ternary complex of ASB9-Elongin B/C as well as the interacting N-terminal domain of Cul5 and used structural comparisons to establish a model for the complete Cul5-based E3 ligase.' Whic... | Elongin-C | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04621","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ASB9 interacts with multiple proteins. One interaction is supported by evidence stating: 'We determined the crystal structures of the ternary complex... | |
medium_divergent_branch_04622 | The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. It consists of swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves. Based on this description, which anat... | mesenchyme | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04622","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. It consists of swellings of t... | |
medium_divergent_branch_04623 | TRIM29 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that TRIM29 interacts with BRCA1-associated surveillance complex, cohesion, a DNA-dependent protein kinase catalytic subunit and components of TIP60 complex.' Which protein, connected to TRIM29 via this interaction, is ... | DNA-dependent protein kinase catalytic subunit | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04623","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM29 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that TRIM29 interacts with BRCA1-associated surv... | |
medium_divergent_branch_04624 | MARK4 is associated with multiple biological processes. One association is supported by evidence stating that overexpression of MARK4 leads to the thinning of the microtubule network and the reorganization of microtubules into bundles. Which biological process, connected to the process described by this evidence via an... | microtubule cytoskeleton organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04624","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MARK4 is associated with multiple biological processes. One association is supported by evidence stating that overexpression of MARK4 leads to the th... | |
medium_divergent_branch_04625 | XRCC5 interacts with multiple genes. One of these interaction partners is supported by evidence stating: 'Tandem affinity purification reveals that Iduna binds to a number of proteins that are either PARsylated or bind PAR including PAR polymerase-1, 2 (PARP1, 2), nucleolin, DNA ligase III, KU70, KU86, XRCC1, and histo... | cytosol | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04625","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"XRCC5 interacts with multiple genes. One of these interaction partners is supported by evidence stating: 'Tandem affinity purification reveals that I... | |
medium_divergent_branch_04626 | ATRX is involved in multiple biological processes. One specific process is characterized by evidence stating: 'Unlike its role in assisting H3.3 chromatin deposition, ATRX acts as a negative regulator of macroH2A's chromatin association.' Which biological process is a parent term (is_a) of this specific process? | cellular component organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04626","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATRX is involved in multiple biological processes. One specific process is characterized by evidence stating: 'Unlike its role in assisting H3.3 chro... | |
medium_divergent_branch_04627 | MCM3 interacts with multiple proteins. One interaction is supported by evidence stating: 'In vitro binding assays indicate that MCM3 does not interact directly with Stat1, suggesting that the presence of MCM3 in the group of Stat1TAD-interacting proteins is due to the association of MCM3 with this protein.' What is the... | DNA replication licensing factor MCM5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04627","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MCM3 interacts with multiple proteins. One interaction is supported by evidence stating: 'In vitro binding assays indicate that MCM3 does not interac... | |
medium_divergent_branch_04628 | CTBP1 interacts with multiple genes. One interaction is supported by evidence stating: 'We identify the CtIP and CtBP corepressors as novel components of the human RBP-Jkappa/[gene]-corepressor complex and show that CtIP binds directly to the [gene] repression domain.' Which disease is associated with the gene identifi... | prostate cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04628","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CTBP1 interacts with multiple genes. One interaction is supported by evidence stating: 'We identify the CtIP and CtBP corepressors as novel component... | |
medium_divergent_branch_04629 | FANCD2 interacts with multiple proteins. One of these interaction partners forms a complex with FANCD2 in a manner that is dependent on BRCA1. Which protein is encoded by the gene corresponding to this BRCA1-dependent interaction partner? | Histone H2AX | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04629","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FANCD2 interacts with multiple proteins. One of these interaction partners forms a complex with FANCD2 in a manner that is dependent on BRCA1. Which ... | |
medium_divergent_branch_04630 | ERBB3 interacts with multiple genes. One of these interaction partners is a 47 kDa ubiquitously expressed protein that binds the ERBB3 receptor in human serum-starved breast cancer cell lines and dissociates upon treatment with the ERBB3 ligand, Heregulin (HRG). Which biological process is this specific interaction par... | negative regulation of DNA-templated transcription | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04630","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ERBB3 interacts with multiple genes. One of these interaction partners is a 47 kDa ubiquitously expressed protein that binds the ERBB3 receptor in hu... | |
medium_divergent_branch_04631 | FLI1 interacts with multiple genes. One interaction is supported by evidence stating: 'As the functional regulators of FLI-1 are largely unknown, we performed a yeast two-hybrid screen with FLI-1 and identified the SUMO E3 ligase [gene] as a novel in vitro and in vivo binding partner of FLI-1.' Which disease is associa... | childhood acute lymphoblastic leukemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04631","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FLI1 interacts with multiple genes. One interaction is supported by evidence stating: 'As the functional regulators of FLI-1 are largely unknown, we ... | |
medium_divergent_branch_04632 | Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.944 and an adjusted p-value of 0.0459. Which disease has a causal relation with that selected gene? | hypersensitivity reaction disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04632","source_qa_id":"medium_divergent_branch_03765","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch sho... | |
medium_divergent_branch_04633 | TACC3 interacts with multiple proteins. One interaction is supported by evidence stating: 'To better understand CCC protein recruitment by the heterodimeric HIF transcription factor, we used x-ray crystallography, NMR spectroscopy, and biochemical methods to investigate the structure of the [protein] PAS-B domain in co... | Aryl hydrocarbon receptor nuclear translocator | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04633","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TACC3 interacts with multiple proteins. One interaction is supported by evidence stating: 'To better understand CCC protein recruitment by the hetero... | |
medium_divergent_branch_04634 | FRS2 interacts with multiple genes. One interaction is supported by the finding that 'the phosphotyrosine binding domain of FRS-2 directly binds the Trk receptors at the same phosphotyrosine residue that binds the signaling adapter Shc.' Which disease is associated with the gene identified by this evidence through geno... | Alzheimer disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04634","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FRS2 interacts with multiple genes. One interaction is supported by the finding that 'the phosphotyrosine binding domain of FRS-2 directly binds the ... | |
medium_divergent_branch_04635 | INO80 is known to bind to multiple gene products. One of these partners is described in the literature as being tightly associated with the human ATP-dependent INO80-like chromatin-remodeling complex. Which gene product, connected to INO80 via a binding interaction, is the subject of this specific description? | BRD3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04635","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"INO80 is known to bind to multiple gene products. One of these partners is described in the literature as being tightly associated with the human ATP... |
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