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medium_divergent_branch_04636 | The gene PARN interacts with multiple partners. One specific interaction is supported by evidence showing that NMD factors, including the hidden candidate, Upf2, and Upf3X, coimmunopurify with the decapping enzyme Dcp2, the putative 5'-->3' exonuclease Rat1, the proven 5'-->3' exonuclease Xrn1, exosomal components PM/S... | Regulator of nonsense transcripts 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04636","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PARN interacts with multiple partners. One specific interaction is supported by evidence showing that NMD factors, including the hidden cand... | |
medium_divergent_branch_04637 | STX3 interacts with multiple genes. One interaction is supported by evidence stating: 'In a yeast two-hybrid assay, syntaxins 2, 3 and 4 interacted with SNAP-23 and VAMP-3.' Which disease is associated with the gene identified in this specific evidence through a biomarker relationship? | atherosclerosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04637","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"STX3 interacts with multiple genes. One interaction is supported by evidence stating: 'In a yeast two-hybrid assay, syntaxins 2, 3 and 4 interacted w... | |
medium_divergent_branch_04638 | AMOTL1 interacts with multiple genes. One of these interacting partners is reported to physically interact with AMOTL1 and enhance its stability via lysine 63-linked ubiquitination. Which disease is associated with this specific interacting gene? | neurodevelopmental disorder with hypotonia, seizures, and absent language | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04638","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AMOTL1 interacts with multiple genes. One of these interacting partners is reported to physically interact with AMOTL1 and enhance its stability via ... | |
medium_divergent_branch_04639 | SOX9 is associated with multiple biological processes. One association is supported by evidence stating: 'It is concluded that the SOX trio have a significantly lower expression in human MSCs than in chondrocytes and that the electroporation-mediated co-transfection of SOX trio enhances chondrogenesis and suppresses hy... | chondrocyte differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04639","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SOX9 is associated with multiple biological processes. One association is supported by evidence stating: 'It is concluded that the SOX trio have a si... | |
medium_divergent_branch_04640 | LRP8 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using a series of receptor mutants, we characterized the interaction of apoER2 with Reelin and compared this interaction to that of apoER2 with the receptor-associated protein, an apoER2 ligand that does not induce signaling.' Whi... | Alpha-2-macroglobulin receptor-associated protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04640","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LRP8 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using a series of receptor mutants, we characterized the in... | |
medium_divergent_branch_04641 | OSBP interacts with multiple genes. One specific interaction was identified through a yeast two-hybrid screen using full-length OSBP as bait, which resulted in the cloning of a vesicle-associated membrane protein-associated protein. Which disease is connected to this specific interacting gene through genomic alteration... | borderline personality disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04641","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"OSBP interacts with multiple genes. One specific interaction was identified through a yeast two-hybrid screen using full-length OSBP as bait, which r... | |
medium_divergent_branch_04642 | ANKRD9 interacts with multiple proteins. One interaction partner is described as follows: 'In addition to its interactions with the other E3 ligase subunits, this protein interacts with two isoforms of inosine monophosphate dehydrogenase (IMPDH).' Which protein, connected to ANKRD9 via an interaction, is the subject of... | Inosine-5'-monophosphate dehydrogenase 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04642","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ANKRD9 interacts with multiple proteins. One interaction partner is described as follows: 'In addition to its interactions with the other E3 ligase s... | |
medium_divergent_branch_04643 | SNAI1 interacts with multiple proteins. One specific interaction partner is an E3 ligase whose binding to Snail is enhanced by NDRG2, leading to Snail degradation via ubiquitination and the maintenance of E-cadherin expression. Which disease is associated with this E3 ligase through genomic alterations? | chronic otitis media | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04643","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SNAI1 interacts with multiple proteins. One specific interaction partner is an E3 ligase whose binding to Snail is enhanced by NDRG2, leading to Snai... | |
medium_divergent_branch_04644 | UBE2I interacts with multiple genes. One interaction is supported by evidence stating: 'In the cytoplasm, a nuclear import receptor associates with different cargoes such as Mago-Y14 and Ubc9, and facilitates their import into the nucleus where RanGTP binding promotes the release of the cargo.' Which disease is associa... | childhood onset asthma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04644","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBE2I interacts with multiple genes. One interaction is supported by evidence stating: 'In the cytoplasm, a nuclear import receptor associates with d... | |
medium_divergent_branch_04645 | SOX5 is associated with multiple biological processes. One association is supported by evidence stating: 'It is concluded that the SOX trio have a significantly lower expression in human MSCs than in chondrocytes and that the electroporation-mediated co-transfection of SOX trio enhances chondrogenesis and suppresses hy... | mesenchymal stem cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04645","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SOX5 is associated with multiple biological processes. One association is supported by evidence stating: 'It is concluded that the SOX trio have a si... | |
medium_divergent_branch_04646 | The gene PPP1CB interacts with multiple partners. One specific interaction is supported by evidence stating: 'Moreover, PP1α, PP1β and Wip1 bind H3-H4 in vitro and in vivo, whereas only PP1α and PP1β, but not Wip1, interact with Pak2 in vivo.' Which protein is encoded by the gene that interacts with PPP1CB in this cont... | Histone H3.1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04646","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PPP1CB interacts with multiple partners. One specific interaction is supported by evidence stating: 'Moreover, PP1α, PP1β and Wip1 bind H3-H... | |
medium_divergent_branch_04647 | An extracellular matrix-secreting cell is a component of a specific anatomical structure. Evidence for this association describes the structure as 'Dense regular connective tissue that connects muscle to bone'. Which broader anatomical system is this specific structure a part of? | musculoskeletal system | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04647","source_qa_id":"medium_divergent_branch_03878","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"An extracellular matrix-secreting cell is a component of a specific anatomical structure. Evidenc... | |
medium_divergent_branch_04648 | IKZF3 interacts with multiple genes. One interaction is supported by evidence stating: 'Using yeast two-hybrid system, coimmunoprecipitation, and indirect immunofluorescence techniques, we found that the interacting partner of Aiolos interacts with the transcription factor Aiolos in IL-4-stimulated cells, increasing up... | gamma-delta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04648","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IKZF3 interacts with multiple genes. One interaction is supported by evidence stating: 'Using yeast two-hybrid system, coimmunoprecipitation, and ind... | |
medium_divergent_branch_04650 | FGF23 interacts with multiple proteins. One interaction is characterized by evidence stating: 'In addition, we observed that the binding of FGF23 to FGFR1c was stronger in OA chondrocytes compared with normal.' Which protein, connected to FGF23 via this specific binding evidence, is encoded by the gene in question? | Fibroblast growth factor receptor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04650","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FGF23 interacts with multiple proteins. One interaction is characterized by evidence stating: 'In addition, we observed that the binding of FGF23 to ... | |
medium_divergent_branch_04651 | In a study of Orthohepevirus A infection in hepatocytes (GSE135619), one downregulated gene exhibits a log2 fold change of -1.025 and an adjusted p-value of 0.03883. Which protein is encoded by this specific gene? | ATPase inhibitor, mitochondrial | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04651","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"In a study of Orthohepevirus A infection in hepatocytes (GSE135619), one downregulated gene exhibits a log2 fold change of -1.025 and an adjusted p-v... | |
medium_divergent_branch_04652 | MSH6 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study, we show that each subunit of the human 9-1-1 complex physically interacts with hMSH2, hMSH3, and hMSH6.' Which protein, connected to MSH6 via this interaction, is encoded by the gene in question? | Cell cycle checkpoint control protein RAD9A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04652","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MSH6 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study, we show that each subunit of the human 9-1-1... | |
medium_divergent_branch_04653 | HAVCR1 (KIM-1) interacts with multiple proteins. One interaction is supported by evidence stating: 'Using a yeast two-hybrid screen, we identified the dynein light chain protein, [REDACTED], as a novel KIM-1-interacting protein.' Which protein, encoded by the gene connected to HAVCR1 via this specific interaction, is t... | Dynein light chain Tctex-type 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04653","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HAVCR1 (KIM-1) interacts with multiple proteins. One interaction is supported by evidence stating: 'Using a yeast two-hybrid screen, we identified th... | |
medium_divergent_branch_04654 | FNBP1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We demonstrate that FBP17 binds via a special [protein]-binding motif to [the protein encoded by TNKS].' Which protein, encoded by the gene connected to FNBP1 via this specific interaction, is the subject of this evidence? | Poly [ADP-ribose] polymerase tankyrase-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04654","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FNBP1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We demonstrate that FBP17 binds via a special [protein]-bi... | |
medium_divergent_branch_04655 | The gene ATN1 interacts with multiple partners. One interaction is supported by evidence stating: 'Our screens identified multiple clones of Atrophin-1, a previously described interactor of a nuclear receptor.' Which protein is encoded by the gene connected to ATN1 via this specific interaction? | Nuclear receptor subfamily 2 group E member 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04655","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ATN1 interacts with multiple partners. One interaction is supported by evidence stating: 'Our screens identified multiple clones of Atrophin... | |
medium_divergent_branch_04656 | MAP3K5 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this report, we show that the protein interacts with MEKK5 through a conserved WW3 domain by the co-immunoprecipitation and the GST-pulldown assays.' Which protein, connected to MAP3K5 via this specific interaction evidence, ... | E3 ubiquitin-protein ligase NEDD4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04656","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP3K5 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this report, we show that the protein interacts with M... | |
medium_divergent_branch_04658 | STC1 is associated with multiple biological processes. One association is supported by evidence stating: 'In the present study, we report that STC1 is a selective modulator of hepatocyte growth factor (HGF)-induced endothelial migration and morphogenesis, but not proliferation.' Which biological process, connected to t... | endothelial cell development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04658","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"STC1 is associated with multiple biological processes. One association is supported by evidence stating: 'In the present study, we report that STC1 i... | |
medium_divergent_branch_04659 | CUL3 interacts with multiple genes. One of these interaction partners is a BTB (Bric-a-brac/Tramtrack/Broad complex) domain-containing protein that serves as a substrate adaptor for CUL3-based ubiquitin ligases. Which gene is this interaction partner? | SPOPL | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04659","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CUL3 interacts with multiple genes. One of these interaction partners is a BTB (Bric-a-brac/Tramtrack/Broad complex) domain-containing protein that s... | |
medium_divergent_branch_04660 | CDR2 interacts with multiple proteins. One of these interactions is supported by evidence stating: 'The interaction between a serine/threonine-protein kinase and PCD17 was also determined by the in vitro binding analysis.' Which protein, connected to CDR2 via this specific interaction evidence, is encoded by the gene i... | Serine/threonine-protein kinase N1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04660","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDR2 interacts with multiple proteins. One of these interactions is supported by evidence stating: 'The interaction between a serine/threonine-protei... | |
medium_divergent_branch_04661 | The biological process 'negative regulation of epithelial tube formation' is defined as any process that stops, prevents, or reduces the frequency, rate, or extent of epithelial tube formation. This process is a subtype of a broader biological process. Which biological process is negatively regulated by that broader pa... | morphogenesis of an epithelium | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04661","source_qa_id":"medium_divergent_branch_05223","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'negative regulation of epithelial tube formation' is defined as any proce... | |
medium_divergent_branch_04662 | JAK1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study, we demonstrate that a specific tyrosine phosphatase is tyrosine-phosphorylated by and associated with JAK1 and JAK2 but not JAK3 in COS-1 cell cotransfection experiments.' Which protein, connected to JAK1 via a bind... | Tyrosine-protein phosphatase non-receptor type 11 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04662","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"JAK1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study, we demonstrate that a specific tyrosine phos... | |
medium_divergent_branch_04663 | GAS2L3 interacts with multiple proteins. One of these interaction partners is supported by evidence stating: 'Biochemical assays show that GAS2L3 directly interacts with the C-terminus of borealin and the N-terminus of a protein encoded by BIRC5.' Which protein, encoded by the gene connected to GAS2L3 via this specific... | Baculoviral IAP repeat-containing protein 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04663","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GAS2L3 interacts with multiple proteins. One of these interaction partners is supported by evidence stating: 'Biochemical assays show that GAS2L3 dir... | |
medium_divergent_branch_04664 | ATXN7L3 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we report that ATXN7L3B interacts with this protein but not other SAGA components.' What does the protein connected to ATXN7L3 via this specific interaction encode? | Transcription and mRNA export factor ENY2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04664","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATXN7L3 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we report that ATXN7L3B interacts with thi... | |
medium_divergent_branch_04665 | SNX5 interacts with multiple proteins. One interaction partner is characterized by a binding mechanism involving a coiled-coil domain present in both SNX5 and the partner, a feature absent in CHC17. Which protein, encoded by the gene corresponding to this specific interaction partner, is the target of the 'encodes' rel... | Clathrin heavy chain 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04665","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SNX5 interacts with multiple proteins. One interaction partner is characterized by a binding mechanism involving a coiled-coil domain present in both... | |
medium_divergent_branch_04666 | HMGB1 is involved in multiple biological processes. One of these processes is characterized by the enhancement of IL-10 release and T(reg) suppressive capacity in a RAGE-dependent manner. Which biological process is positively regulated by this specific HMGB1-associated process? | interleukin-10 production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04666","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HMGB1 is involved in multiple biological processes. One of these processes is characterized by the enhancement of IL-10 release and T(reg) suppressiv... | |
medium_divergent_branch_04667 | The myocardial endocrine cell of the septal division of the left branch of the atrioventricular bundle is a type of which of the following cell classes? Contextual clue: This cell type is defined as a myocardial endocrine cell that is part of the septal division of the left branch of the atrioventricular bundle. | cardiac muscle cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04667","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The myocardial endocrine cell of the septal division of the left branch of the atrioventricular bundle is a type of which of the following cell class... | |
medium_divergent_branch_04669 | RNF115 interacts with multiple proteins. One interaction is characterized by the finding that 14-3-3 chaperones bind to AKT1-phosphorylated RNF115, facilitating its localization to the endoplasmic reticulum and the Golgi apparatus. Which protein, among those interacting with RNF115, is the one described in this specifi... | 14-3-3 protein zeta/delta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04669","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF115 interacts with multiple proteins. One interaction is characterized by the finding that 14-3-3 chaperones bind to AKT1-phosphorylated RNF115, f... | |
medium_divergent_branch_04670 | CDKN2A interacts with multiple proteins. One interaction is supported by evidence stating: 'To understand the mechanism of ARF-mediated tumor suppression, we identified a ubiquitin ligase, ARF-BP1, as a key factor associated with ARF in vivo.' Which disease is linked to this specific interacting partner via genomic alt... | leukopenia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04670","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDKN2A interacts with multiple proteins. One interaction is supported by evidence stating: 'To understand the mechanism of ARF-mediated tumor suppres... | |
medium_divergent_branch_04671 | The gene EFNA1 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 5.74 TPM, a z-score of 2.19, and a fold enrichment of 6.52. Identify the cell type that corresponds to this statistical profile and is linked via the 'develops from' relationship to its precursor... | mature CD8 single-positive thymocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04671","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene EFNA1 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 5.74 TPM, a z-score of 2... | |
medium_divergent_branch_04672 | Protein Kinase X (PRKX) is involved in a biological process supported by evidence stating: 'Unlike the ubiquitous PKA, the cAMP-dependent CREB-kinase, Protein Kinase X is developmentally regulated, tissue restricted and induces renal epithelial cell migration, and tubulogenesis in vitro as well as branching morphogenes... | epithelial cell differentiation involved in kidney development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04672","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Protein Kinase X (PRKX) is involved in a biological process supported by evidence stating: 'Unlike the ubiquitous PKA, the cAMP-dependent CREB-kinase... | |
medium_divergent_branch_04673 | MPHOSPH8 interacts with multiple proteins. One of these interaction partners is reported to also interact with self-methylated EHMT1 in a methylation-dependent manner. Which protein is encoded by the gene corresponding to this specific interaction partner? | Histone-lysine N-methyltransferase EHMT1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04673","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MPHOSPH8 interacts with multiple proteins. One of these interaction partners is reported to also interact with self-methylated EHMT1 in a methylation... | |
medium_divergent_branch_04674 | USP4 interacts with multiple proteins. One specific interaction is characterized by the binding partner attaching to the opposite surface of the HAT-C dimer interface, utilizing the β-structured linker located between the DUSP and UBL domains. Which protein corresponds to this specific interaction partner? | Spliceosome associated factor 3, U4/U6 recycling protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04674","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP4 interacts with multiple proteins. One specific interaction is characterized by the binding partner attaching to the opposite surface of the HAT-... | |
medium_divergent_branch_04675 | CEBPB interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Furthermore, we show that C/EBPbeta and a histone acetyltransferase interact with each other and demonstrate that the sequences responsible for interaction map to the E1A binding region of the histone acetyltransferase a... | Histone acetyltransferase p300 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04675","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CEBPB interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Furthermore, we show that C/EBPbeta and a histone... | |
medium_divergent_branch_04676 | ERBB2 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'Transfection of cells with erbB3 and ERBB2 reconstitutes a higher affinity binding receptor, which is also capable of generating a tyrosine phosphorylation signal in response... | signaling receptor activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04676","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ERBB2 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'Tra... | |
medium_divergent_branch_04678 | Interleukin-27 (IL-27) is associated with multiple biological processes. One specific association is supported by evidence stating that IL-27 is an early product of activated antigen-presenting cells and drives rapid clonal expansion of naive but not memory CD4(+) T cells. Which biological process, connected to the pro... | T cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04678","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Interleukin-27 (IL-27) is associated with multiple biological processes. One specific association is supported by evidence stating that IL-27 is an e... | |
medium_divergent_branch_04679 | RAB5A interacts with multiple proteins. One of these interaction partners is described as a protein that specifically binds the active GTP-bound form of Rab5 and is recruited to early endosomes in a Rab5-dependent manner. Which disease is associated with this specific interaction partner via a biomarker relationship? | juvenile myelomonocytic leukemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04679","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAB5A interacts with multiple proteins. One of these interaction partners is described as a protein that specifically binds the active GTP-bound form... | |
medium_divergent_branch_04680 | MAP3K3 interacts with multiple genes. One of these interacting partners has been shown to specifically interact with MEKK3 and potentiate MEKK3-mediated AP1 and CHOP activation. Which disease is associated with this specific interacting partner? | cardiac, facial, and digital anomalies with developmental delay | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04680","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP3K3 interacts with multiple genes. One of these interacting partners has been shown to specifically interact with MEKK3 and potentiate MEKK3-media... | |
medium_divergent_branch_04681 | CDKN1C interacts with multiple genes. One of these interactions is supported by mechanistic studies showing that a kinase interacts with p57 (Kip2) and causes cytoplasmic localization of p57 (Kip2). Which cell type is the gene involved in this specific interaction enriched in? | eosinophil | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04681","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDKN1C interacts with multiple genes. One of these interactions is supported by mechanistic studies showing that a kinase interacts with p57 (Kip2) a... | |
medium_divergent_branch_04682 | The gene ABHD11 is enriched in multiple cell types. One specific cell type shows a mean expression of 34.51 TPM, a z-score of 1.86, and a fold enrichment of 2.42 for this gene. Which cell type is the developmental precursor to this specific cell type? | intermediate monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04682","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ABHD11 is enriched in multiple cell types. One specific cell type shows a mean expression of 34.51 TPM, a z-score of 1.86, and a fold enrich... | |
medium_divergent_branch_04683 | LGALS1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Direct interaction between the gene product and galectin-1 was demonstrated in glutathione S-transferase (GST) pull-down assays.' Which disease is associated with the gene identified by this specific interaction evidence? | neurodevelopmental disorder with microcephaly, cataracts, and renal abnormalities | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04683","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LGALS1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Direct interaction between the gene product and ga... | |
medium_divergent_branch_04684 | ZDHHC23 interacts with multiple proteins. One interaction is supported by evidence stating: 'In vitro pull-down assays suggested that the C-terminal tail region of NIDD specifically interacted with the PDZ domain of the protein encoded by NOS1.' Which protein, encoded by the gene connected to ZDHHC23 via this specific ... | Nitric oxide synthase 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04684","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZDHHC23 interacts with multiple proteins. One interaction is supported by evidence stating: 'In vitro pull-down assays suggested that the C-terminal ... | |
medium_divergent_branch_04685 | The biological process 'regulation of B cell deletion' is defined as any process that modulates the frequency, rate, or extent of B cell deletion. This process is a subtype of which broader biological process? | regulation of lymphocyte apoptotic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04685","source_qa_id":"medium_divergent_branch_03437","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'regulation of B cell deletion' is defined as any process that modulates t... | |
medium_divergent_branch_04686 | The gene FAM175A (also known as ABRAXAS1) interacts with multiple protein partners. One specific interaction is supported by evidence stating: 'We provided evidence that NBA1 interacts with a partner protein through a C-terminal conserved motif of the NBA1 protein and a C-terminal UEV domain of the partner protein.' Ba... | BRISC and BRCA1-A complex member 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04686","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene FAM175A (also known as ABRAXAS1) interacts with multiple protein partners. One specific interaction is supported by evidence stating: 'We pr... | |
medium_divergent_branch_04688 | NUP88 interacts with multiple proteins. One of these interaction partners is described as having a pore-targeting domain that interacts directly with the cytoplasmic nucleoporin NUP88, which is a component of the Nup214-Nup88-Nup62 subcomplex. Which protein, connected to NUP88 via a binding interaction, is the subject ... | Nuclear pore complex protein Nup98-Nup96 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04688","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NUP88 interacts with multiple proteins. One of these interaction partners is described as having a pore-targeting domain that interacts directly with... | |
medium_divergent_branch_04689 | SEC23B interacts with multiple proteins. One specific interaction is characterized by the following evidence: 'Here, we show that the F-box protein targets SEC23B, a component of COPII, for proteasomal degradation and that this event limits the autophagic flux in the presence of nutrients.' What is the name of the prot... | F-box/WD repeat-containing protein 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04689","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SEC23B interacts with multiple proteins. One specific interaction is characterized by the following evidence: 'Here, we show that the F-box protein t... | |
medium_divergent_branch_04690 | MCL1 is associated with multiple biological processes. One association is supported by evidence that MCL-1 is an antiapoptotic BCL-2 family protein. Which biological process, connected to the process supported by this evidence via an 'is a' relationship, represents the broader category? | homeostatic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04690","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MCL1 is associated with multiple biological processes. One association is supported by evidence that MCL-1 is an antiapoptotic BCL-2 family protein. ... | |
medium_divergent_branch_04691 | NOX1 is associated with multiple biological processes. One association is supported by evidence stating: 'Using Nox1 siRNA, we show that Nox1-dependent superoxide production affects the migration of HT29-D4 colonic adenocarcinoma cells on collagen-I.' Which cell type is linked to the biological process described in thi... | M1 macrophage | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04691","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NOX1 is associated with multiple biological processes. One association is supported by evidence stating: 'Using Nox1 siRNA, we show that Nox1-depende... | |
medium_divergent_branch_04692 | The protein CENPE is associated with multiple molecular functions. One specific function is supported by evidence stating that Centromere-associated protein E (CENP-E)/Kinesin-7 is a microtubule plus-end-directed kinetochore motor required for congression of pole-proximal chromosomes. Which molecular function, connecte... | tubulin binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04692","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein CENPE is associated with multiple molecular functions. One specific function is supported by evidence stating that Centromere-associated ... | |
medium_divergent_branch_04693 | AMOTL2 interacts with multiple genes. One specific interaction partner was identified and confirmed as a novel binding partner of AMOTL2 in NSCLC cells using mass spectrometry, co-immunoprecipitation, GST pull-down, and immunofluorescence. Which disease is associated with this specific interaction partner via a biomark... | urinary bladder carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04693","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AMOTL2 interacts with multiple genes. One specific interaction partner was identified and confirmed as a novel binding partner of AMOTL2 in NSCLC cel... | |
medium_divergent_branch_04694 | FGF10 is associated with multiple biological processes. One specific association is supported by evidence that recombinant human FGF-10 induces the proliferation of human urothelial cells in vitro and the transitional epithelium of wild-type and FGF7-null mice in vivo. Which biological process, connected to the process... | epithelial cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04694","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FGF10 is associated with multiple biological processes. One specific association is supported by evidence that recombinant human FGF-10 induces the p... | |
medium_divergent_branch_04695 | PIP5K1C interacts with multiple proteins. One of these interaction partners is described as having its inhibitory function in EGFR sorting neutralized by the endosomal PIP kinase PIPKIγi5, which directly binds this partner and generates PtdIns(4,5)P2. Which protein is connected to PIP5K1C through the 'interacts with' r... | Lysosomal-associated transmembrane protein 4B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04695","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PIP5K1C interacts with multiple proteins. One of these interaction partners is described as having its inhibitory function in EGFR sorting neutralize... | |
medium_divergent_branch_04696 | USP36 is reported to interact with multiple genes. One specific interaction is supported by evidence stating: 'In addition, endogenous USP36 and the target gene were shown to interact in an immunoprecipitation assay, which was verified using the yeast two-hybrid system.' Identify the gene that interacts with USP36 base... | NIPSNAP1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04696","source_qa_id":"medium_divergent_branch_01992","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"USP36 is reported to interact with multiple genes. One specific interaction is supported by evide... | |
medium_divergent_branch_04697 | CTCFL interacts with multiple proteins. One interacting partner is a protein arginine methyltransferase that is expressed during embryonic testis development. Which protein is encoded by the gene for this specific interacting partner? | Protein arginine N-methyltransferase 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04697","source_qa_id":"medium_divergent_branch_06526","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"CTCFL interacts with multiple proteins. One interacting partner is a protein arginine methyltrans... | |
medium_divergent_branch_04698 | NUFIP1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here, we solve the nuclear magnetic resonance (NMR) structure of a complex resulting from interaction between protein fragments of human NUFIP1 and its cofactor, and emphasize their imbrication.' Which protein, encoded ... | Zinc finger HIT domain-containing protein 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04698","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NUFIP1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here, we solve the nuclear magnetic resonance (N... | |
medium_divergent_branch_04699 | TRIM38 interacts with multiple proteins. One specific interaction is characterized by the mechanism where TRIM38 binds to heat shock protein family A member 5 and stabilizes it via K63-dependent ubiquitination. Which protein product is encoded by the gene corresponding to this specific interacting partner? | Endoplasmic reticulum chaperone BiP | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04699","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM38 interacts with multiple proteins. One specific interaction is characterized by the mechanism where TRIM38 binds to heat shock protein family A... | |
medium_divergent_branch_04701 | The VHL protein interacts with multiple partners. One specific interaction is characterized by evidence stating that 'pVHL was found to possess the LIR motif within a beta domain that interacted with this partner and ubiquitinated it.' Which disease is associated with this specific interacting partner via a biomarker r... | breast carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04701","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The VHL protein interacts with multiple partners. One specific interaction is characterized by evidence stating that 'pVHL was found to possess the L... | |
medium_divergent_branch_04702 | An ectodermal placode is a thickening of the ectoderm that serves as the precursor for many structures derived from the ectoderm. This entity is classified as a specific type of anatomical entity. Which broader anatomical category is this entity a part of? | multicellular organism | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04702","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"An ectodermal placode is a thickening of the ectoderm that serves as the precursor for many structures derived from the ectoderm. This entity is clas... | |
medium_divergent_branch_04704 | FAM175A (Abraxas) interacts with multiple proteins. One specific interaction is characterized by the association of Abraxas and the target protein through coiled-coil domains present on both molecules. Which protein, encoded by the gene connected to FAM175A via this specific interaction, is the target? | Lys-63-specific deubiquitinase BRCC36 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04704","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FAM175A (Abraxas) interacts with multiple proteins. One specific interaction is characterized by the association of Abraxas and the target protein th... | |
medium_divergent_branch_04705 | SPRY2 interacts with multiple proteins. One specific interaction partner is reported to physically associate with endogenous PKCdelta in cells upon basic fibroblast growth factor stimulation, a finding that underscores the physiological relevance of this interaction. Which protein is encoded by the gene corresponding t... | Protein kinase C delta type | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04705","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SPRY2 interacts with multiple proteins. One specific interaction partner is reported to physically associate with endogenous PKCdelta in cells upon b... | |
medium_divergent_branch_04706 | The tooth placode is a thickening of the ectoderm that will give rise to the tooth bud. Which anatomical entity is a direct superclass of the tooth placode? | ectodermal placode | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04706","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The tooth placode is a thickening of the ectoderm that will give rise to the tooth bud. Which anatomical entity is a direct superclass of the tooth p... | |
medium_divergent_branch_04707 | hsa-miR-146a-5p regulates more than one cell type. Evidence for one of these regulatory connections reports the expression of miR-223, miR-146a, miR-495, and miR-107 in plasma and the selected cell, along with measurements of blood glucose concentration and the selected cell's activation rate. Which anatomical structur... | blood clot | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04707","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"hsa-miR-146a-5p regulates more than one cell type. Evidence for one of these regulatory connections reports the expression of miR-223, miR-146a, miR-... | |
medium_divergent_branch_04708 | CLSTN1 interacts with multiple proteins. One interaction is supported by evidence stating that Alcadeins (Alcs)/calsyntenins and the amyloid beta-protein precursor associate in the brain by binding via their cytoplasmic domains to X11L. Which protein, encoded by the gene connected to CLSTN1 through this specific intera... | Amyloid-beta precursor protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04708","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CLSTN1 interacts with multiple proteins. One interaction is supported by evidence stating that Alcadeins (Alcs)/calsyntenins and the amyloid beta-pro... | |
medium_divergent_branch_04709 | The gene CD40LG is enriched in multiple cell types. One specific cell type exhibits a mean expression of 68.91 TPM, a z-score of 1.78, and a fold enrichment of 6.23. Which cell type does this specific cell develop from? | mature CD4 single-positive thymocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04709","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CD40LG is enriched in multiple cell types. One specific cell type exhibits a mean expression of 68.91 TPM, a z-score of 1.78, and a fold enr... | |
medium_divergent_branch_04710 | IRS1 interacts with multiple genes. One specific interaction involves a protein that functions as an E3 ligase, ubiquitinating IRS-1 in skeletal muscle; disrupting this interaction is proposed as a strategy to treat insulin resistance by elevating IRS-1 levels. Which disease is associated with this specific interacting... | hyperinsulinism | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04710","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IRS1 interacts with multiple genes. One specific interaction involves a protein that functions as an E3 ligase, ubiquitinating IRS-1 in skeletal musc... | |
medium_divergent_branch_04711 | The gene POLE is known to interact with several other genes. One specific interaction is supported by evidence stating: 'However, phosphorylated hRad17 preferentially associates with the sites of ongoing DNA replication and interacts with the DNA replication protein, DNA polymerase epsilon.' Based on this description, ... | Cell cycle checkpoint protein RAD17 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04711","source_qa_id":"medium_divergent_branch_01894","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene POLE is known to interact with several other genes. One specific interaction is supporte... | |
medium_divergent_branch_04712 | ANGPTL8 is associated with multiple biological processes. One of these associations is supported by evidence stating that inhibition of ANGPTL8 provides a new therapeutic strategy for reducing plasma lipoprotein levels. Which biological process is a parent term (via an 'is a' relationship) of the specific process linke... | regulation of protein metabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04712","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ANGPTL8 is associated with multiple biological processes. One of these associations is supported by evidence stating that inhibition of ANGPTL8 provi... | |
medium_divergent_branch_04713 | The gene PNN interacts with multiple partners. One specific interaction is supported by evidence stating: 'In support of a role for the interacting partner in pre-mRNA splicing, we identified PRP6, SWAP, and pinin as interacting proteins and demonstrated that this partner is a U5 snRNP-associated kinase.' Which protein... | Serine/threonine-protein kinase PRP4 homolog | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04713","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PNN interacts with multiple partners. One specific interaction is supported by evidence stating: 'In support of a role for the interacting p... | |
medium_divergent_branch_04714 | SENP1 interacts with multiple proteins. One of these interaction partners was studied in a structural biology context where researchers determined the structures of catalytically inactive SENP1 bound to SUMO-1-modified versions of this partner and to unprocessed SUMO-1 to establish the proteolytic mechanism. Which prot... | Ran GTPase-activating protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04714","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SENP1 interacts with multiple proteins. One of these interaction partners was studied in a structural biology context where researchers determined th... | |
medium_divergent_branch_04715 | SPARC is associated with multiple biological processes. One association is supported by evidence stating: 'In contrast, peptides Z-2 (6.1 kDa, containing Ca2+-binding EF hand-1) and Z-3 (2.2 kDa, containing neither Cu2+-binding motifs nor EF hands), inhibited cell proliferation in a concentration-dependent manner and e... | endothelial cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04715","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SPARC is associated with multiple biological processes. One association is supported by evidence stating: 'In contrast, peptides Z-2 (6.1 kDa, contai... | |
medium_divergent_branch_04717 | The gene IKBKB interacts with multiple partners. One interaction is supported by evidence stating: 'Here, we show that an E3-ubiquitin ligase [Protein X] interacts weakly with wild-type IKKbeta but strongly with a phosphomimetic mutant IKKbeta to conjugate monoubiquitin in cooperation with an E2-ubiquitin-conjugating e... | E3 ubiquitin-protein ligase TRIM21 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04717","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene IKBKB interacts with multiple partners. One interaction is supported by evidence stating: 'Here, we show that an E3-ubiquitin ligase [Protei... | |
medium_divergent_branch_04718 | DSC1 interacts with multiple genes. One of these interaction partners is described by the following evidence: 'This mutant transmembrane receptor, which does not bind the common desmosomal plaque proteins plakoglobin and plakophilin 1, is integrated into functional desmosomes.' Which disease is associated with this spe... | Parkinson disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04718","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DSC1 interacts with multiple genes. One of these interaction partners is described by the following evidence: 'This mutant transmembrane receptor, wh... | |
medium_divergent_branch_04719 | KATNB1 interacts with multiple genes. One of these interaction partners is supported by evidence stating: 'The microtubule-severing protein katanin, a heterodimer of 60 and 80 kDa subunits, was previously purified and shown to localize to centrosomes in vivo.' Identify the biological process associated with this specif... | cytoplasmic microtubule organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04719","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KATNB1 interacts with multiple genes. One of these interaction partners is supported by evidence stating: 'The microtubule-severing protein katanin, ... | |
medium_divergent_branch_04720 | ADAM17 interacts with multiple genes. One interaction is supported by evidence comparing the binding affinity and association rate constants of the N-terminal domain of wild-type tissue inhibitor of metalloproteinase (TIMP-3) and its mutants against full-length recombinant TACE and the truncated form of its catalytic d... | negative regulation of membrane protein ectodomain proteolysis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04720","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ADAM17 interacts with multiple genes. One interaction is supported by evidence comparing the binding affinity and association rate constants of the N... | |
medium_divergent_branch_04721 | Phospholipase D1 (PLD1) preferentially interacts with two closely related Arf family GTPases, ARL11 and another protein, showing that PLD1 is activated by this pair and may recruit these GTPases to membrane vesicles. What is the full protein name encoded by the gene for this second interacting GTPase? | ADP-ribosylation factor-like protein 14 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04721","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Phospholipase D1 (PLD1) preferentially interacts with two closely related Arf family GTPases, ARL11 and another protein, showing that PLD1 is activat... | |
medium_divergent_branch_04722 | DUSP14 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using yeast-hybrid technology, we cloned a novel [protein] cytoplasmic tail ([protein] CYT) interacting protein, MAP kinase phosphatase-6 (MKP6), which we demonstrate inactivates MAP kinases.' Which protein, connected to DUSP14 ... | T-cell-specific surface glycoprotein CD28 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04722","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DUSP14 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using yeast-hybrid technology, we cloned a novel [protein... | |
medium_divergent_branch_04723 | CREB3 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We confirmed their direct binding by glutathione S-transferase pull-down assays, and verified the existence of such interaction in the cellular environment by mammalian two-hybrid and co-immunoprecipitation assays.' Whic... | COP9 signalosome complex subunit 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04723","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CREB3 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We confirmed their direct binding by glutathione ... | |
medium_divergent_branch_04724 | The dorsal nerve root of the cervical spinal cord is structurally related to two candidate anatomical entities. One of these candidates is supported by evidence stating that it overlaps a cervical spinal cord. Which of these candidates extends fibers into a specific target structure? | dorsal root ganglion | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04724","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The dorsal nerve root of the cervical spinal cord is structurally related to two candidate anatomical entities. One of these candidates is supported ... | |
medium_divergent_branch_04725 | PRPF40B interacts with multiple proteins. One of these interaction partners contains a domain capable of binding specifically to the Group II WW domains of splicing factors formin-binding protein (FBP) 11 and HYPC. Which protein is this interaction partner? | Methyl-CpG-binding protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04725","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRPF40B interacts with multiple proteins. One of these interaction partners contains a domain capable of binding specifically to the Group II WW doma... | |
medium_divergent_branch_04726 | The gene AIPL1 is reported to interact with multiple proteins. One specific interaction was verified by co-immunoprecipitation studies in Y79 retinoblastoma cells, demonstrating that this interaction occurs within cells that share a number of features with retinal progenitor cells. Which protein is encoded by the gene ... | NEDD8 ultimate buster 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04726","source_qa_id":"medium_divergent_branch_04114","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene AIPL1 is reported to interact with multiple proteins. One specific interaction was verif... | |
medium_divergent_branch_04727 | PIK3C3 interacts with multiple proteins. One interaction partner is an F-box protein that mediates the ubiquitination and proteasomal degradation of phosphorylated Vps34 (a component of PIK3C3) following DNA damage-activated mitotic arrest and CDK activation. This process involves the Skp1-Cullin1 complex and leads to ... | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04727","source_qa_id":"medium_divergent_branch_06620","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"PIK3C3 interacts with multiple proteins. One interaction partner is an F-box protein that mediate... | |
medium_divergent_branch_04728 | Pulmonary neuroendocrine cells are a type of cell found in the respiratory epithelium of the lung. They are involved in the sensory detection of environmental stimuli, including hypoxia, nicotine, and air pressure. Ultrastructurally, these cells are characterized by cytoplasmic dense-core granules that store amine and ... | sensory receptor cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04728","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Pulmonary neuroendocrine cells are a type of cell found in the respiratory epithelium of the lung. They are involved in the sensory detection of envi... | |
medium_divergent_branch_04730 | ENPP1 is associated with multiple biological processes. One association is supported by evidence stating that RNA-sequencing analysis of patient-derived primary melanocytes revealed alterations in melanocyte development and in pigmentation signaling pathways. Which biological process, connected to the process supported... | pigment cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04730","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ENPP1 is associated with multiple biological processes. One association is supported by evidence stating that RNA-sequencing analysis of patient-deri... | |
medium_divergent_branch_04731 | SIVA1 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we show that Siva-1 binds to and inhibits [anti-apoptotic protein]-mediated protection against UV radiation-induced apoptosis.' Which disease is connected to the gene identified by this evidence through a protective relationsh... | stroke disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04731","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SIVA1 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we show that Siva-1 binds to and inhibits [anti-apoptot... | |
medium_divergent_branch_04732 | NES interacts with multiple proteins. One specific interaction is supported by evidence stating that the interacting partner binds the cytoplasmic intermediate filament protein nestin with high affinity. Which protein is encoded by the gene corresponding to this interacting partner? | Insulin-degrading enzyme | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04732","source_qa_id":"medium_divergent_branch_06614","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"NES interacts with multiple proteins. One specific interaction is supported by evidence stating t... | |
medium_divergent_branch_04733 | The gene ABL2 interacts with multiple other genes. One of these interacting partners is described in literature as a protein that associates with and serves as a substrate for Arg and v-Abl, and is phosphorylated on tyrosine in v-Abl-transformed cells. Which protein is encoded by the gene corresponding to this specific... | Sorbin and SH3 domain-containing protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04733","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ABL2 interacts with multiple other genes. One of these interacting partners is described in literature as a protein that associates with and... | |
medium_divergent_branch_04734 | GPR65 is enriched in multiple cell types. One of these cell types exhibits a mean expression of 60.98 TPM, a z-score of 1.79, and a fold enrichment of 3.20. Which cell type is the developmental precursor of the cell type matching these expression statistics? | double-positive, alpha-beta thymocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04734","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GPR65 is enriched in multiple cell types. One of these cell types exhibits a mean expression of 60.98 TPM, a z-score of 1.79, and a fold enrichment o... | |
medium_divergent_branch_04735 | The CHRNA7 gene product is associated with multiple cellular components via 'located in' relationships. One specific association is supported by evidence stating: 'Activation of the α7*nAChR results in opening of the channel and entry of mono- and divalent cations, including Ca(2+), that presynaptically participates to... | synaptic membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04735","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The CHRNA7 gene product is associated with multiple cellular components via 'located in' relationships. One specific association is supported by evid... | |
medium_divergent_branch_04736 | RAD52 interacts with multiple proteins. One of these interaction partners is reported to relocate from nucleoli to arrested replication forks in the nucleoplasm following the introduction of interstrand DNA crosslinks (ICL), where it interacts with the homologous recombination protein RAD52. Which protein product is en... | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04736","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAD52 interacts with multiple proteins. One of these interaction partners is reported to relocate from nucleoli to arrested replication forks in the ... | |
medium_divergent_branch_04737 | The gene HTR6 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'Here, we report the structures of the serotonin receptors 5-HT4, 5-HT6, and 5-HT7 with Gs, and 5-HT4 with Gi1.' Identify the molecular function linked to HTR6 by this... | G protein-coupled amine receptor activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04737","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene HTR6 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stati... | |
medium_divergent_branch_04738 | FANCL interacts with multiple proteins. One specific interaction is described as a direct protein-protein interaction between the FA core complex and hairy enhancer of split 1. Which protein product is encoded by the gene corresponding to hairy enhancer of split 1? | Transcription factor HES-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04738","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FANCL interacts with multiple proteins. One specific interaction is described as a direct protein-protein interaction between the FA core complex and... | |
medium_divergent_branch_04739 | COMMD1 interacts with multiple genes. One of these interaction partners is described in a study stating: 'We report here that a histone acetyltransferase, associates with this protein and other components of the ligase, promotes RelA ubiquitination, and represses kappaB-dependent transcription.' Which disease is associ... | colon carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04739","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"COMMD1 interacts with multiple genes. One of these interaction partners is described in a study stating: 'We report here that a histone acetyltransfe... | |
medium_divergent_branch_04740 | TRAF6 interacts with multiple genes. One of these interaction partners is described in the following evidence: 'We demonstrate that TNF-associated factor (TRAF) 4 associates with p47(phox), a component of cytosolic NADPH oxidase, and physically interacts and functionally counteracts with TRAF6 and Toll-IL-1 receptor (T... | metabolic bone disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04740","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRAF6 interacts with multiple genes. One of these interaction partners is described in the following evidence: 'We demonstrate that TNF-associated fa... | |
medium_divergent_branch_04741 | SKP2 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this report we provide evidence that MAGE-A11 interacts with Skp2 (S phase kinase-associated protein), the substrate recognition protein of the Skp1-Cullin1-F-box E3 ubiquitin ligase, and with Skp2 binding protein, cyclin A.' W... | Cyclin-A2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04741","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SKP2 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this report we provide evidence that MAGE-A11 interacts ... | |
medium_divergent_branch_04742 | SMAD5 is implicated in multiple biological processes. One connection is supported by evidence stating: 'Because we inhibited osteoclast differentiation with loss of either Smad4 or Smad1/5 expression, we assessed whether BMPs affected osteoclast activity in addition to BMP's effects on differentiation.' Identify the bi... | cellular developmental process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04742","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMAD5 is implicated in multiple biological processes. One connection is supported by evidence stating: 'Because we inhibited osteoclast differentiati... | |
medium_divergent_branch_04743 | PAX6 is associated with multiple biological processes. One specific association is supported by evidence stating: 'We conclude that PAX6 is critical for α cell function and differentiation through the transcriptional control of key genes involved in glucagon gene transcription, proglucagon processing, and α cell differ... | pancreatic A cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04743","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PAX6 is associated with multiple biological processes. One specific association is supported by evidence stating: 'We conclude that PAX6 is critical ... | |
medium_divergent_branch_04744 | The gene CSF3R interacts with multiple partners via binding. One specific interaction is characterized by the recruitment of the partner protein to activated G-CSF-R, a process mediated by direct binding through the partner's SH2 domain to multiple phosphotyrosines on the receptor. Which protein is encoded by the gene ... | Tyrosine-protein kinase HCK | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04744","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CSF3R interacts with multiple partners via binding. One specific interaction is characterized by the recruitment of the partner protein to a... |
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