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medium_divergent_branch_04745 | TAL1 is involved in multiple biological processes. One such process is supported by evidence that GATA-1 modulates TAL1 transcription during the differentiation of erythroid, megakaryocytic, and basophilic lineages. Which cell type is the result of the biological process connected to TAL1 via 'results in acquisition of... | megakaryocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04745","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TAL1 is involved in multiple biological processes. One such process is supported by evidence that GATA-1 modulates TAL1 transcription during the diff... | |
medium_divergent_branch_04746 | CCNE2 interacts with multiple proteins. One interaction involves a partner that forms a functional kinase complex with Cyclin E2, which is inhibited by both p27(Kip1) and p21(Cip1). Which protein is encoded by the gene corresponding to this interacting partner? | Cyclin-dependent kinase 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04746","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CCNE2 interacts with multiple proteins. One interaction involves a partner that forms a functional kinase complex with Cyclin E2, which is inhibited ... | |
medium_divergent_branch_04747 | Pyramidal neurons are anatomical components of specific cortical layers. One such layer is described as a layer of the neocortex lying deep to the external granule cell layer and defined cytoarchitecturally by numerous small pyramidal neurons. Which anatomical structure, connected to pyramidal neurons via a 'part of' r... | layer of neocortex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04747","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Pyramidal neurons are anatomical components of specific cortical layers. One such layer is described as a layer of the neocortex lying deep to the ex... | |
medium_divergent_branch_04748 | PDPK1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Thereafter, PDK1 stably interacted with 14-3-3ε and was dephosphorylated;'. Which protein, encoded by the gene connected to PDPK1 via this specific interaction, is the subject of this evidence? | 14-3-3 protein epsilon | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04748","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PDPK1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Thereafter, PDK1 stably interacted with 14-3-3ε and was de... | |
medium_divergent_branch_04749 | Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.295 and an adjusted p-value of 0.035. Which protein does that selected gene encode? | Stathmin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04749","source_qa_id":"medium_divergent_branch_06078","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch sho... | |
medium_divergent_branch_04750 | CDKN2C interacts with multiple proteins. One interaction partner is described in a study stating: 'In this paper, we identified the protein as a deubiquitinase of p18, which binds to and removes the K48-linked polyubiquitylation chains conjugated onto p18, thus stabilizing the p18 protein.' What is the name of the prot... | Ubiquitin carboxyl-terminal hydrolase CYLD | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04750","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDKN2C interacts with multiple proteins. One interaction partner is described in a study stating: 'In this paper, we identified the protein as a deub... | |
medium_divergent_branch_04751 | TRAF2 interacts with multiple proteins. One interaction partner is supported by evidence stating that a specific receptor associates with TRAF1, this protein, and TRAF3, and induces nuclear factor (NF)-kappaB activation via this protein. Which protein is encoded by the gene corresponding to this interaction partner? | Tumor necrosis factor receptor superfamily member 18 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04751","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRAF2 interacts with multiple proteins. One interaction partner is supported by evidence stating that a specific receptor associates with TRAF1, this... | |
medium_divergent_branch_04752 | The gene KDR is known to interact with multiple proteins. One specific interaction is described by the following evidence: 'We show that tyrosine phosphorylation of VEGF receptor 2 (VEGFR2) at Y951 facilitates binding of VEGFR2 to the Rous sarcoma (Src) homology 2-domain of a T cell-specific adaptor protein, which in t... | SH2 domain-containing protein 2A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04752","source_qa_id":"medium_divergent_branch_05263","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene KDR is known to interact with multiple proteins. One specific interaction is described b... | |
medium_divergent_branch_04753 | The biological process 'positive regulation of myelination' is defined as any process that activates or increases the frequency, rate, or extent of the formation of a myelin sheath around nerve axons. This process is a subtype of a broader regulatory category. Which biological process is positively regulated by this br... | nervous system process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04753","source_qa_id":"medium_divergent_branch_01076","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'positive regulation of myelination' is defined as any process that activa... | |
medium_divergent_branch_04754 | ING2 is implicated in multiple biological processes. One specific connection is supported by evidence stating: 'This study establishes ING2 as a novel regulator of spermatogenesis functioning through both p53- and chromatin-mediated mechanisms.' Based on this evidence, identify the biological process to which ING2 is d... | spermatid differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04754","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ING2 is implicated in multiple biological processes. One specific connection is supported by evidence stating: 'This study establishes ING2 as a nove... | |
medium_divergent_branch_04755 | FBLN1 interacts with multiple proteins. One interaction is supported by evidence stating: 'The calcium-binding basement membrane protein fibulin-1C was shown to bind nidogen in a calcium-dependent fashion.' Which protein, encoded by the gene connected to FBLN1 via this specific interaction, is the target of the 'encode... | Nidogen-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04755","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBLN1 interacts with multiple proteins. One interaction is supported by evidence stating: 'The calcium-binding basement membrane protein fibulin-1C w... | |
medium_divergent_branch_04756 | MIR15B is associated with multiple biological processes. One association is supported by evidence that miR-15b-5p significantly promoted or depressed the migration and proliferation of endothelial cells. Which biological process is negatively regulated by the process linked to this endothelial cell evidence? | vascular endothelial cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04756","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR15B is associated with multiple biological processes. One association is supported by evidence that miR-15b-5p significantly promoted or depressed... | |
medium_divergent_branch_04757 | AKT2 interacts with multiple proteins. One interaction is described by the evidence: 'We show that the interaction of a CAP-Gly domain-containing protein with Akt is mediated by the CAP-Gly domain of this protein and kinase domain of Akt and is regulated by Akt phosphorylation.' Which protein, encoded by the gene conne... | CAP-Gly domain-containing linker protein 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04757","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AKT2 interacts with multiple proteins. One interaction is described by the evidence: 'We show that the interaction of a CAP-Gly domain-containing pro... | |
medium_divergent_branch_04758 | Non-terminally differentiated osteoblasts are part of more than one anatomical structure. One of these structures is described as mineralized tissue that always includes non-terminally differentiated osteoblasts and osteocytes. Which anatomical structure, connected to the non-terminally differentiated osteoblast via a ... | mineralized bone tissue | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04758","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Non-terminally differentiated osteoblasts are part of more than one anatomical structure. One of these structures is described as mineralized tissue ... | |
medium_divergent_branch_04759 | The NPHP3 gene is associated with multiple biological processes. One association is supported by evidence stating: 'In humans, we show that NPHP3 mutations can cause a broad clinical spectrum of early embryonic patterning defects comprising situs inversus, polydactyly, central nervous system malformations, structural h... | kidney development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04759","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The NPHP3 gene is associated with multiple biological processes. One association is supported by evidence stating: 'In humans, we show that NPHP3 mut... | |
medium_divergent_branch_04760 | LBP is associated with multiple biological processes. One association is supported by evidence stating that LBP may control the response to LPS under physiologic conditions by forming high-affinity complexes with LPS that bind to monocytes and macrophages, which then secrete tumor necrosis factor. Which biological proc... | tumor necrosis factor production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04760","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LBP is associated with multiple biological processes. One association is supported by evidence stating that LBP may control the response to LPS under... | |
medium_divergent_branch_04761 | West Nile virus upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.093 and an adjusted p-value of 0.0204. For which disease is that selected gene recorded as a biomarker? | osteoporosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04761","source_qa_id":"medium_divergent_branch_06216","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"West Nile virus upregulates several genes. In the recorded experiment, one branch showed a log... | |
medium_divergent_branch_04762 | The gene FES is associated with multiple biological processes. One association is supported by evidence stating: 'These results suggest that Fps/Fes may play a general role in the regulation of vesicular trafficking.' Identify the biological process linked to FES that is described by this evidence. Then, determine whic... | vesicle-mediated transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04762","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene FES is associated with multiple biological processes. One association is supported by evidence stating: 'These results suggest that Fps/Fes ... | |
medium_divergent_branch_04763 | SMC1A interacts with multiple proteins. One interaction is supported by evidence stating: 'We previously used gene editing to introduce a dual epitope tag into the endogenous allele of each of 11 known components of cohesin in human HCT116 cells.' Which protein, encoded by the gene interacting with SMC1A in this contex... | Ubiquitin carboxyl-terminal hydrolase 13 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04763","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMC1A interacts with multiple proteins. One interaction is supported by evidence stating: 'We previously used gene editing to introduce a dual epitop... | |
medium_divergent_branch_04764 | The gene HIST1H3A interacts with multiple proteins. One interaction is supported by evidence stating: 'The double tudor domain of a Jmjc domain-containing histone demethylase, binds methylated histone H3-K4 and H4-K20.' Which protein, connected to HIST1H3A via an interaction, is encoded by the gene corresponding to thi... | Lysine-specific demethylase 4A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04764","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene HIST1H3A interacts with multiple proteins. One interaction is supported by evidence stating: 'The double tudor domain of a Jmjc domain-conta... | |
medium_divergent_branch_04765 | KIF5B interacts with multiple proteins. One interaction is supported by evidence stating: 'This screen initially identified synaptosome-associated protein of 25 kDa as a kinesin-binding protein.' Which protein is encoded by the gene corresponding to this interaction partner? | Synaptosomal-associated protein 25 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04765","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KIF5B interacts with multiple proteins. One interaction is supported by evidence stating: 'This screen initially identified synaptosome-associated pr... | |
medium_divergent_branch_04766 | RBMX interacts with multiple proteins. One interaction is characterized by the finding that the SH2 domain of the interacting partner, specifically amino acids Y413 and D443, serves as a critical binding site for the RRM domain of RBMX, as demonstrated by co-IP and GST-pulldown experiments. Which protein, encoded by th... | Suppressor of cytokine signaling 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04766","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RBMX interacts with multiple proteins. One interaction is characterized by the finding that the SH2 domain of the interacting partner, specifically a... | |
medium_divergent_branch_04767 | PTPN23 interacts with multiple proteins. One interaction partner is described as an ESCRT protein (HD-PTP) that forms complexes with ESCRT-0, -I, and -III proteins and binds to Endofin, a FYVE-domain protein confined to endosomes. Which protein is encoded by the gene corresponding to this specific interaction partner? | Zinc finger FYVE domain-containing protein 16 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04767","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PTPN23 interacts with multiple proteins. One interaction partner is described as an ESCRT protein (HD-PTP) that forms complexes with ESCRT-0, -I, and... | |
medium_divergent_branch_04768 | PJA1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In vitro binding and immunoprecipitation assays demonstrated that both PJA1 and PJA2 are able to bind the ubiquitin-conjugating enzyme [REDACTED].' Which protein, connected to PJA1 via an interaction, is the subject of this specif... | Ubiquitin-conjugating enzyme E2 D2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04768","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PJA1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In vitro binding and immunoprecipitation assays demonstrate... | |
medium_divergent_branch_04769 | DDX1 interacts with multiple genes. One specific interaction is supported by evidence stating that immunoprecipitation with an antibody targeting a phosphorylated residue at position 102 (pT102) of the interacting partner resulted in the co-isolation of that partner with DDX1 in a phosphatase-sensitive manner. Which di... | amyotrophic lateral sclerosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04769","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DDX1 interacts with multiple genes. One specific interaction is supported by evidence stating that immunoprecipitation with an antibody targeting a p... | |
medium_divergent_branch_04770 | TRAF6 interacts with multiple genes. One of these interacting partners has been shown to directly interact with TRAF6 and degrade the TRAF6 protein via polyubiquitination. Which cellular component is the gene corresponding to this specific interacting partner located in? | cytoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04770","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRAF6 interacts with multiple genes. One of these interacting partners has been shown to directly interact with TRAF6 and degrade the TRAF6 protein v... | |
medium_divergent_branch_04772 | CHMP1A interacts with multiple genes. One interaction is supported by evidence stating: 'Immunocytochemistry and biochemical fractionation localize CHMP1 to early endosomes and CHMP1 physically interacts with a highly conserved protein directly linked to multivesicular body sorting in yeast.' Which disease is associate... | cerebellar hypoplasia-intellectual disability-congenital microcephaly-dystonia-anemia-growth retardation syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04772","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CHMP1A interacts with multiple genes. One interaction is supported by evidence stating: 'Immunocytochemistry and biochemical fractionation localize C... | |
medium_divergent_branch_04773 | CD82 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we demonstrate that two other tetraspans, CD82 and the early B cell marker CD9, are coimmunoprecipitated with the shared protein from Brij97 lysates of B cell lines.' Which protein is encoded by the gene corresponding to this... | B-lymphocyte antigen CD19 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04773","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CD82 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we demonstrate that two other tetraspans, CD82 and the... | |
medium_divergent_branch_04774 | NOD2 interacts with multiple proteins. Experimental evidence confirms the primary interaction for a specific subset of these partners, including ANKHD1, CHMP5, SDCCAG3, LDOC1, PPP1R12C, KRT15, PPP2R3B, and C10Orf67, via coimmunoprecipitation and/or bioluminescence resonance energy transfer (BRET). One of the proteins i... | Dedicator of cytokinesis protein 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04774","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NOD2 interacts with multiple proteins. Experimental evidence confirms the primary interaction for a specific subset of these partners, including ANKH... | |
medium_divergent_branch_04775 | HDAC5 interacts with multiple proteins. One interaction is supported by evidence stating: 'Since a BCL6 relative, which could also interact with HDAC4, -5, and 7, we suggest that class II HDACs are largely involved in the control of the POK transcription factors activity.' Which protein, encoded by the gene correspondi... | Zinc finger and BTB domain-containing protein 16 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04775","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HDAC5 interacts with multiple proteins. One interaction is supported by evidence stating: 'Since a BCL6 relative, which could also interact with HDAC... | |
medium_divergent_branch_04776 | TDRD3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we have identified ubiquitin-specific protease 9 X-linked as a TDRD3-interacting protein by GST (glutathione...'. Which protein, connected to TDRD3 via this specific interaction, is the subject of the 'encodes' relationship... | Ubiquitin carboxyl-terminal hydrolase 9X | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04776","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TDRD3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we have identified ubiquitin-specific protease 9 X-l... | |
medium_divergent_branch_04779 | The gene PRKAB1 interacts with multiple partners via protein-protein binding. One specific interaction is supported by evidence stating: 'In addition to binding of each noncatalytic subunit to the alpha subunit, the beta and gamma subunits bind to each other, likely resulting in a more stable heterotrimeric complex.' I... | 5'-AMP-activated protein kinase subunit gamma-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04779","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PRKAB1 interacts with multiple partners via protein-protein binding. One specific interaction is supported by evidence stating: 'In addition... | |
medium_divergent_branch_04780 | The gene ENG is enriched in two distinct monocyte subtypes. One subtype exhibits a mean expression of 23.29 TPM, a z-score of 1.91, and a fold enrichment of 5.36. Which cell type does this specific ENG-enriched subtype develop from? | classical monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04780","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ENG is enriched in two distinct monocyte subtypes. One subtype exhibits a mean expression of 23.29 TPM, a z-score of 1.91, and a fold enrich... | |
medium_divergent_branch_04782 | Clusterin (CLU) interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we report that clusterin, a protein newly demonstrated to interact with eHsp90α, modulates eHsp90α signaling.' Which protein, encoded by the gene connected to CLU via this specific interaction, is the subject of t... | Heat shock protein HSP 90-alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04782","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Clusterin (CLU) interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we report that clusterin, a protein newly ... | |
medium_divergent_branch_04783 | The gene ACVRL1 interacts with multiple partners. One specific interaction is supported by the finding that 'ALK1 in endothelial cells binds to TGF-beta1 and TbetaR-II.' Identify the disease causally linked to the gene involved in this specific binding event. | arterial tortuosity syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04783","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ACVRL1 interacts with multiple partners. One specific interaction is supported by the finding that 'ALK1 in endothelial cells binds to TGF-b... | |
medium_divergent_branch_04784 | FMR1 interacts with multiple proteins. One of these interaction partners is described in the literature as an autosomal homolog that interacts tightly with FMR1 and FXR2. Which protein, encoded by the gene corresponding to this interaction partner, is the subject of this description? | RNA-binding protein FXR1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04784","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FMR1 interacts with multiple proteins. One of these interaction partners is described in the literature as an autosomal homolog that interacts tightl... | |
medium_divergent_branch_04785 | MIR346 is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence stating: 'Overexpression of miR-346 significantly promoted osteogenic differentiation, whereas miR-346 depletion suppressed this process.' Identify the biological process that is... | cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04785","source_qa_id":"medium_divergent_branch_02233","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"MIR346 is associated with multiple biological processes via the 'involved in' relationship. One s... | |
medium_divergent_branch_04787 | The gene TRGV3 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 49.81 TPM, a z-score of 1.62, and a fold enrichment of 4.73. Which cell type, defined by this specific expression profile, is a subtype of mature alpha-beta T cells? | mature alpha-beta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04787","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TRGV3 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 49.81 TPM, a z-score of ... | |
medium_divergent_branch_04788 | BCL11A is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence stating that knockdown of BCL11A induced axon branching, multi-axon formation, and dendrite outgrowth. Which biological process, connected to the process supported by this eviden... | dendrite development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04788","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BCL11A is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence stating... | |
medium_divergent_branch_04789 | The gene KDR is known to interact with multiple proteins. One specific interaction is supported by evidence describing the crystal structure of a ligand bound to the VEGFR-2 high-affinity-binding site, which consists of immunoglobulin homology domains D2 and D3. Which protein is encoded by the gene that interacts with ... | Vascular endothelial growth factor C | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04789","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene KDR is known to interact with multiple proteins. One specific interaction is supported by evidence describing the crystal structure of a lig... | |
medium_divergent_branch_04790 | MACROH2A1 is associated with multiple biological processes. One association is supported by evidence stating that MACROH2A1 splicing isoforms differentially regulate the transcription of a set of genes involved in redox metabolism. Which biological process, connected to the process supported by this evidence via a 'reg... | response to oxidative stress | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04790","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MACROH2A1 is associated with multiple biological processes. One association is supported by evidence stating that MACROH2A1 splicing isoforms differe... | |
medium_divergent_branch_04792 | FANCA interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Additionally, we showed that AMPKα interacted with FANCA, another component of the FA nuclear core complex.' Which disease is associated with this AMPKα-interacting protein through genomic alterations? | hypoglycemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04792","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FANCA interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Additionally, we showed that AMPKα interacted wit... | |
medium_divergent_branch_04794 | FGF8 is implicated in multiple biological processes. One line of evidence highlights its role in a process linked to hypogonadotropic hypogonadism, citing the identification of missense mutations in FGF8 in patients with variable olfactory phenotypes and GnRH deficiency. Which biological process, connected to this spec... | development of primary sexual characteristics | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04794","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FGF8 is implicated in multiple biological processes. One line of evidence highlights its role in a process linked to hypogonadotropic hypogonadism, c... | |
medium_divergent_branch_04795 | SHANK3 is associated with multiple biological processes. One association is supported by evidence reporting morphological abnormalities in synapses (spine number, width, and length) and impaired glutamatergic synaptic transmission, indicated by a reduction in the frequency of miniature excitatory postsynaptic currents ... | synaptic transmission, glutamatergic | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04795","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SHANK3 is associated with multiple biological processes. One association is supported by evidence reporting morphological abnormalities in synapses (... | |
medium_divergent_branch_04796 | ERBB3 interacts with multiple proteins. One specific interaction is described by the evidence: 'We show that the EGF-like domain of heregulin binds to domains I and II of HER3'. Which protein isoform is encoded by the gene identified as heregulin in this context? | Pro-neuregulin-1, membrane-bound isoform | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04796","source_qa_id":"medium_divergent_branch_06579","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ERBB3 interacts with multiple proteins. One specific interaction is described by the evidence: 'W... | |
medium_divergent_branch_04797 | USP19 interacts with multiple genes. One specific interaction is characterized by the finding that USP19 binds to the partner protein, prevents its polyubiquitination, and subsequently extends its half-life. Which disease is associated with this specific interacting partner? | phenylketonuria | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04797","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP19 interacts with multiple genes. One specific interaction is characterized by the finding that USP19 binds to the partner protein, prevents its p... | |
medium_divergent_branch_04799 | The gene ALDOA is associated with multiple biological processes. One association is supported by clinical evidence describing transfusion-dependent anemia, increasing muscle weakness, and death at age 4 due to rhabdomyolysis and hyperkalemia. Which biological process, defined as a parent term of the process linked by t... | cellular homeostasis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04799","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ALDOA is associated with multiple biological processes. One association is supported by clinical evidence describing transfusion-dependent a... | |
medium_divergent_branch_04801 | DTX3 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Using this probe, we identified the E3 ligase DTX3 as an E2-selective probe target and demonstrated that DTX3 forms a thioester-linked intermediate with [the interacting partner].' Which protein is encoded by the gene that i... | Ubiquitin-conjugating enzyme E2 L3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04801","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DTX3 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Using this probe, we identified the E3 ligase DTX3 as... | |
medium_divergent_branch_04802 | UNC13B interacts with multiple genes. One interaction is supported by evidence stating: 'In the present study, we demonstrate by three independent methods that the C terminus of Munc13-1 interacts directly with a putative coiled coil domain in the N-terminal part of syntaxin.' Which disease is associated with the gene ... | generalized epilepsy with febrile seizures plus, type 9 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04802","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UNC13B interacts with multiple genes. One interaction is supported by evidence stating: 'In the present study, we demonstrate by three independent me... | |
medium_divergent_branch_04803 | MYD88 interacts with multiple proteins. One of these interaction partners is described by the following evidence: 'We further show that this protein binds to and ubiquitinates the innate immune adaptor protein MyD88.' Which protein, connected to MYD88 via an interaction, is the subject of this description? (Note: The f... | E3 ubiquitin-protein ligase SIAH1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04803","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MYD88 interacts with multiple proteins. One of these interaction partners is described by the following evidence: 'We further show that this protein ... | |
medium_divergent_branch_04804 | CHD1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We also present evidence for an in vivo interaction between CHD1 and a novel HMG box-containing protein, which involves an amino-terminal segment of CHD1 that does not include the chromodomain.' Which protein product is e... | FACT complex subunit SSRP1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04804","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CHD1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We also present evidence for an in vivo interactio... | |
medium_divergent_branch_04805 | The chemokine receptor CCR9 is associated with multiple biological processes. One specific association is supported by experimental evidence showing that cells transfected with cDNAs for CCR9 variants responded to the chemokine CCL25 (also known as TECK or CK beta-15) in assays measuring both calcium flux and a specifi... | taxis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04805","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The chemokine receptor CCR9 is associated with multiple biological processes. One specific association is supported by experimental evidence showing ... | |
medium_divergent_branch_04806 | HSPA2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Quantitative proteomics and biochemical analysis revealed that this protein interacted with and targeted heat-shock protein family A member 2 (HSPA2), a putative oncoprotein that is frequently upregulated in human cancer and prom... | E3 ubiquitin-protein ligase RNF144A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04806","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HSPA2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Quantitative proteomics and biochemical analysis revealed ... | |
medium_divergent_branch_04807 | KMT2A (also known as MLL) interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we show MLL interacts directly with the polymerase associated factor complex (PAFc) through sequences flanking the CxxC domain.' Which protein, encoded by the gene connected to KMT2A via this spe... | RNA polymerase II-associated factor 1 homolog | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04807","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KMT2A (also known as MLL) interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we show MLL interacts di... | |
medium_divergent_branch_04808 | KRT8 interacts with multiple proteins. One interaction is supported by evidence stating: 'By a bacterial two-hybrid screening, we identify a new [protein]-interacting partner, keratin 8 (K8), a major intermediate filament protein protecting the cell from Fas-mediated apoptosis.' Which protein, connected to KRT8 via thi... | Piwi-like protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04808","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KRT8 interacts with multiple proteins. One interaction is supported by evidence stating: 'By a bacterial two-hybrid screening, we identify a new [pro... | |
medium_divergent_branch_04810 | CABIN1 interacts with multiple genes. One of these interaction partners was recently identified as a transcriptional repressor of MEF2, a complex that can be dissociated in a calcium-dependent manner. Which disease is associated with this specific interaction partner? | myxoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04810","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CABIN1 interacts with multiple genes. One of these interaction partners was recently identified as a transcriptional repressor of MEF2, a complex tha... | |
medium_divergent_branch_04812 | SMURF2 interacts with multiple proteins. One specific interaction is characterized by evidence showing that SMURF2 induces the poly-ubiquitination of the partner protein and shortens its half-life. Which protein, encoded by the gene connected to SMURF2 via this specific interaction, is the subject of this evidence? | Transcriptional repressor protein YY1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04812","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMURF2 interacts with multiple proteins. One specific interaction is characterized by evidence showing that SMURF2 induces the poly-ubiquitination of... | |
medium_divergent_branch_04813 | TAB1 interacts with multiple proteins. One interaction is supported by evidence stating: 'The human X-chromosome-linked inhibitor of apoptosis protein was isolated as a TAB1-binding protein.' Which protein product is encoded by the gene corresponding to this interaction partner? | E3 ubiquitin-protein ligase XIAP | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04813","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TAB1 interacts with multiple proteins. One interaction is supported by evidence stating: 'The human X-chromosome-linked inhibitor of apoptosis protei... | |
medium_divergent_branch_04814 | PTK2B interacts with multiple genes. One of these interacting partners was identified as a substrate for Pyk2 and coimmunoprecipitated with Pyk2, but notably did not coimmunoprecipitate with the closely related focal adhesion kinase FAK. Which disease is associated with this specific interacting gene? | B-cell chronic lymphocytic leukemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04814","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PTK2B interacts with multiple genes. One of these interacting partners was identified as a substrate for Pyk2 and coimmunoprecipitated with Pyk2, but... | |
medium_divergent_branch_04815 | ORC3 interacts with multiple proteins. One interaction partner is supported by evidence listing the following binary interactions: HsOrc2-HsOrc3, HsOrc2-HsOrc4, HsOrc3-HsOrc4, HsOrc2-HsOrc6, and HsOrc3-HsOrc6. Which disease is associated with this specific interaction partner? | Meier-Gorlin syndrome 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04815","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ORC3 interacts with multiple proteins. One interaction partner is supported by evidence listing the following binary interactions: HsOrc2-HsOrc3, HsO... | |
medium_divergent_branch_04816 | AGER is associated with multiple biological processes. One of these processes is supported by evidence stating that HMGB1 enhances IL-10 release and T(reg) suppressive capacity in a RAGE-dependent manner. Which biological process is a parent term (via 'is a') of the process linked to AGER by this evidence? | regulation of alpha-beta T cell activation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04816","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AGER is associated with multiple biological processes. One of these processes is supported by evidence stating that HMGB1 enhances IL-10 release and ... | |
medium_divergent_branch_04817 | PTPN11 interacts with multiple proteins. One specific interaction is characterized by the formation of in vivo complexes in mammalian cells that are regulated in a growth-factor-dependent manner. Which protein, among those interacting with PTPN11, is described by this specific experimental evidence? | Bifunctional coenzyme A synthase | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04817","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PTPN11 interacts with multiple proteins. One specific interaction is characterized by the formation of in vivo complexes in mammalian cells that are ... | |
medium_divergent_branch_04818 | TNFRSF1A interacts with multiple proteins. One interaction is supported by evidence stating that hUBC9, an E2 ubiquitin conjugating enzyme, was identified via yeast two-hybrid screening and coprecipitation studies to interact with MEKK1 and the type I TNF-alpha receptor. Which protein, connected to TNFRSF1A through thi... | SUMO-conjugating enzyme UBC9 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04818","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TNFRSF1A interacts with multiple proteins. One interaction is supported by evidence stating that hUBC9, an E2 ubiquitin conjugating enzyme, was ident... | |
medium_divergent_branch_04819 | ALDOA interacts with multiple genes. One interaction is supported by evidence showing that Aldolase A was co-immunoprecipitated with the partner protein in COS-7 cells overexpressing both ALDOA and the partner, exhibiting binding properties similar to those of aldolase C. Which disease is associated with this specific ... | neuroblastoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04819","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ALDOA interacts with multiple genes. One interaction is supported by evidence showing that Aldolase A was co-immunoprecipitated with the partner prot... | |
medium_divergent_branch_04820 | TRIM31 interacts with multiple proteins. One of these interaction partners is reported to directly bind to NSE4, suggesting the formation of a complex reminiscent of the NSE1-NSE3-NSE4 trimer. Which protein, encoded by the gene connected to TRIM31 via this specific interaction, is the subject of this evidence? | Non-structural maintenance of chromosomes element 4 homolog A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04820","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM31 interacts with multiple proteins. One of these interaction partners is reported to directly bind to NSE4, suggesting the formation of a comple... | |
medium_divergent_branch_04821 | TSG101 interacts with multiple proteins. One specific interaction is characterized by evidence stating that the K848R mutation does not affect the degradation of a specific protein by the lysosomal pathway but significantly reduces its secretion by inhibiting the interaction between this protein and tumor susceptibilit... | Prominin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04821","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TSG101 interacts with multiple proteins. One specific interaction is characterized by evidence stating that the K848R mutation does not affect the de... | |
medium_divergent_branch_04822 | The WRN protein interacts with multiple partners. One specific interaction partner is described as interacting with BLM, WRN, and replication protein A (RPA) complexes during the S-phase of the cell cycle. Which protein is encoded by the gene corresponding to this specific interaction partner? | E3 ubiquitin-protein ligase HERC2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04822","source_qa_id":"medium_divergent_branch_03392","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The WRN protein interacts with multiple partners. One specific interaction partner is described a... | |
medium_divergent_branch_04823 | PHF19 interacts with multiple proteins. One of these interaction partners is described as interacting with both isoforms and mediating hPCL3S degradation through K48-linked ubiquitination in NSCLC cells. Which protein is this interaction partner? | E3 ubiquitin-protein ligase TRIM21 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04823","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PHF19 interacts with multiple proteins. One of these interaction partners is described as interacting with both isoforms and mediating hPCL3S degrada... | |
medium_divergent_branch_04824 | AMOTL2 interacts with multiple proteins. One of these interaction partners is described as binding MST2, LATS2, and YAP, suggesting it functions as a scaffold protein. Which protein, connected to AMOTL2 via a binding interaction, matches this description? | Transcriptional coactivator YAP1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04824","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AMOTL2 interacts with multiple proteins. One of these interaction partners is described as binding MST2, LATS2, and YAP, suggesting it functions as a... | |
medium_divergent_branch_04825 | The pulmonary artery is developmentally derived from more than one anatomical structure. One such precursor is described by the following evidence: 'An artery that carries deoxygenated blood from heart to the lungs. They are the only arteries (other than umbilical arteries in the fetus) that carry deoxygenated blood.' ... | pharyngeal arch artery | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04825","source_qa_id":"medium_divergent_branch_06544","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The pulmonary artery is developmentally derived from more than one anatomical structure. One such... | |
medium_divergent_branch_04827 | SOX17 is associated with multiple biological processes. One association is supported by evidence stating: 'We demonstrate that stable endoderm progenitors can be established from human ES cells by constitutive expression of SOX7 or SOX17, producing extraembryonic endoderm and definitive endoderm progenitors, respective... | endoderm development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04827","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SOX17 is associated with multiple biological processes. One association is supported by evidence stating: 'We demonstrate that stable endoderm progen... | |
medium_divergent_branch_04828 | MFAP1 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we show that human THO interacts with MFAP1 (microfibrillar-associated protein 1), a spliceosome-associated factor.' Which disease is associated with the gene identified in this specific interaction? | hearing loss, autosomal dominant 86 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04828","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MFAP1 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we show that human THO interacts with MFAP1 (microfibri... | |
medium_divergent_branch_04829 | DNM1L interacts with multiple proteins. One of these interaction partners recruits Drp1 to mitochondria in a manner independent of hFis1, Mff (mitochondrial fission factor), and Mfn2 (mitofusin 2), but inhibits Drp1 activity, thereby exerting a negative effect on mitochondrial fission. Which protein is this interaction... | Mitochondrial dynamics protein MIEF1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04829","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DNM1L interacts with multiple proteins. One of these interaction partners recruits Drp1 to mitochondria in a manner independent of hFis1, Mff (mitoch... | |
medium_divergent_branch_04830 | FBXL2 interacts with multiple proteins. One interaction involves a substrate where FBXL2 uniquely targets a calmodulin-binding signature to facilitate polyubiquitination, rather than binding a phosphodegron as is typical for other F-box proteins. Which protein, encoded by the gene connected to FBXL2 via this specific i... | G1/S-specific cyclin-D2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04830","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBXL2 interacts with multiple proteins. One interaction involves a substrate where FBXL2 uniquely targets a calmodulin-binding signature to facilitat... | |
medium_divergent_branch_04831 | MIB1 interacts with multiple genes. One of these interacting partners has been shown to physically and functionally interact with the E3 ubiquitin ligase Mindbomb 1 (MIB1). Which disease is associated with this specific interacting gene through genomic alterations? | cleft palate | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04831","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIB1 interacts with multiple genes. One of these interacting partners has been shown to physically and functionally interact with the E3 ubiquitin li... | |
medium_divergent_branch_04833 | The gene HMOX1 is enriched in multiple cell types. One specific cell type exhibits a mean expression of 265.33 TPM, a z-score of 2.00, and a fold enrichment of 11.50 for this gene. Which cell type is the developmental precursor to the cell type identified by these expression statistics? | intermediate monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04833","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene HMOX1 is enriched in multiple cell types. One specific cell type exhibits a mean expression of 265.33 TPM, a z-score of 2.00, and a fold enr... | |
medium_divergent_branch_04834 | PIN1 interacts with multiple proteins. One interaction is supported by evidence stating: 'we show that upon treatment with chemotherapeutic drugs c-Abl enhances the phosphorylation-dependent interaction between Pin1 and the protein encoded by the gene connected to PIN1 via this specific interaction.' Which protein, enc... | Tumor protein p73 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04834","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PIN1 interacts with multiple proteins. One interaction is supported by evidence stating: 'we show that upon treatment with chemotherapeutic drugs c-A... | |
medium_divergent_branch_04835 | PKM interacts with multiple genes. One specific interaction is supported by Co-IP and immunofluorescence assays, which demonstrated that the interacting partner binds to PKM2, thereby interfering with PKM2's protein stability and inducing its ubiquitin-mediated degradation. Which cell type is the gene involved in this ... | naive B cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04835","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PKM interacts with multiple genes. One specific interaction is supported by Co-IP and immunofluorescence assays, which demonstrated that the interact... | |
medium_divergent_branch_04836 | IRF4 interacts with multiple proteins. One specific interaction involving IRF4 was analyzed using a co-immunoprecipitation assay. Which protein, connected to IRF4 via this interaction, is encoded by the gene in question? | Ubiquitin carboxyl-terminal hydrolase 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04836","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IRF4 interacts with multiple proteins. One specific interaction involving IRF4 was analyzed using a co-immunoprecipitation assay. Which protein, conn... | |
medium_divergent_branch_04837 | BIRC2 interacts with multiple genes. One interaction partner is described in evidence stating that it interacts with members of the TNFR-1 signaling complex, including cIAP1 and specific TRAF family members (TRAF1, TRAF5, and TRAF6), but not TRAF2, TRAF3, or TRAF4. Which disease is associated with this interaction part... | obesity disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04837","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BIRC2 interacts with multiple genes. One interaction partner is described in evidence stating that it interacts with members of the TNFR-1 signaling ... | |
medium_divergent_branch_04838 | RNF168 interacts with multiple proteins. One of these interaction partners is an E3 ubiquitin ligase that has been shown to directly interact with and ubiquitinate RNF168. Which protein, encoded by the gene connected to RNF168 via this specific interaction, is the subject of this description? | E3 ubiquitin-protein ligase RNF126 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04838","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF168 interacts with multiple proteins. One of these interaction partners is an E3 ubiquitin ligase that has been shown to directly interact with an... | |
medium_divergent_branch_04839 | FBXL2 interacts with multiple genes. Evidence for one of these interactions indicates that FBXL2 binds specifically to the C-terminal fragment (CTF) of the target protein, thereby promoting the ubiquitination of that fragment. Which cell type is enriched in the gene corresponding to this specific interaction? | plasmacytoid dendritic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04839","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBXL2 interacts with multiple genes. Evidence for one of these interactions indicates that FBXL2 binds specifically to the C-terminal fragment (CTF) ... | |
medium_divergent_branch_04840 | KCNE5 is associated with multiple biological processes. One association is supported by evidence stating: 'Here we show that KCNE5 induces both a time- and voltage-dependent modulation of the KCNQ1 current.' Which biological process, connected to the process supported by this evidence via a 'regulates' relationship, is... | potassium ion transmembrane transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04840","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KCNE5 is associated with multiple biological processes. One association is supported by evidence stating: 'Here we show that KCNE5 induces both a tim... | |
medium_divergent_branch_04841 | RPTOR interacts with multiple proteins. One interaction is supported by evidence stating: 'The Rag GTPases play an essential role in relaying amino acid signals to TORC1 activation through direct interaction with raptor and recruitment of the TORC1 complex to lysosomes.' Which disease is associated with the gene encodi... | Long-Olsen-Distelmaier syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04841","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RPTOR interacts with multiple proteins. One interaction is supported by evidence stating: 'The Rag GTPases play an essential role in relaying amino a... | |
medium_divergent_branch_04842 | The biological process 'regulation of tRNA export from nucleus' is defined as any process that modulates the frequency, rate, or extent of tRNA export from the nucleus. This process is a subtype of two distinct broader biological processes. One of these broader processes is defined by its regulation of the general expo... | RNA export from nucleus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04842","source_qa_id":"medium_divergent_branch_03833","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'regulation of tRNA export from nucleus' is defined as any process that mo... | |
medium_divergent_branch_04843 | LIG4 interacts with multiple proteins. One interaction is described as a stable coiled-coil-mediated interaction, which is qualitatively different from the direct interactions observed between XLF/Nej1 and DNA ligase IV. Which protein, connected to LIG4 through this specific stable coiled-coil interaction, is the gene ... | DNA repair protein XRCC4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04843","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LIG4 interacts with multiple proteins. One interaction is described as a stable coiled-coil-mediated interaction, which is qualitatively different fr... | |
medium_divergent_branch_04844 | OTUD4 interacts with multiple proteins. Evidence for one of these interactions states: 'Rather, OTUD4 is a scaffold for [Protein A] and USP9X, two deubiquitinases that act directly on the AlkB proteins.' Which protein, encoded by the gene connected to OTUD4 via this specific interaction, is described in this evidence? | Ubiquitin carboxyl-terminal hydrolase 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04844","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"OTUD4 interacts with multiple proteins. Evidence for one of these interactions states: 'Rather, OTUD4 is a scaffold for [Protein A] and USP9X, two de... | |
medium_divergent_branch_04845 | GRB10 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Finally, we show that the endogenous Grb10 and the protein encoded by the interaction partner gene can be co-immunoprecipitated from a partially purified mitochondrial extract, an interaction that is enhanced following t... | RAF proto-oncogene serine/threonine-protein kinase | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04845","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GRB10 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Finally, we show that the endogenous Grb10 and th... | |
medium_divergent_branch_04846 | KDM5B interacts with multiple proteins. One specific interaction partner is identified as a protein that functions as a SUMO E3 ligase and exhibits increased interaction with KDM5B under hypoxic conditions. Which protein is encoded by the gene corresponding to this specific interaction partner? | E3 SUMO-protein ligase PIAS4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04846","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KDM5B interacts with multiple proteins. One specific interaction partner is identified as a protein that functions as a SUMO E3 ligase and exhibits i... | |
medium_divergent_branch_04847 | USP9X interacts with multiple proteins. One of these interaction partners is described in a study stating: 'We show that USP9X interacts with both these ubiquitin E3 ligases, regulating their abundance through the control of protein stability.' Which protein, among the interaction partners of USP9X, is described by thi... | E3 ubiquitin-protein ligase ZNF598 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04847","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP9X interacts with multiple proteins. One of these interaction partners is described in a study stating: 'We show that USP9X interacts with both th... | |
medium_divergent_branch_04849 | The gene CACUL1 interacts with multiple proteins. One specific interaction is described by the evidence: 'Here, we report that CDK2-associated cullin 1 (CACUL1) directly associates with the target protein and suppresses its transcriptional activity.' Which protein, encoded by the gene connected to CACUL1 via this speci... | Androgen receptor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04849","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CACUL1 interacts with multiple proteins. One specific interaction is described by the evidence: 'Here, we report that CDK2-associated cullin... | |
medium_divergent_branch_04850 | HTRA2 is involved in multiple biological processes. One specific connection is supported by evidence stating: 'In the presence of GRIM-19, the HtrA2-driven destruction of the antiapoptotic protein X-linked inhibitor of apoptosis (XIAP) is augmented.' Which biological process is positively regulated by the process descr... | execution phase of apoptosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04850","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HTRA2 is involved in multiple biological processes. One specific connection is supported by evidence stating: 'In the presence of GRIM-19, the HtrA2-... | |
medium_divergent_branch_04851 | USP12 interacts with multiple proteins. One of these interaction partners is a WD40 repeat-containing protein that also interacts with USP46 and is required for histone deubiquitination activity. Which protein is encoded by the gene corresponding to this specific interaction partner? | WD repeat-containing protein 48 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04851","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP12 interacts with multiple proteins. One of these interaction partners is a WD40 repeat-containing protein that also interacts with USP46 and is r... | |
medium_divergent_branch_04852 | MED15 interacts with multiple genes. One interaction is supported by evidence stating: 'Here we show that this activator-recruited cofactor (ARC) interacts directly with several different activators, including SREBP-1a, VP16 and the p65 subunit of NF-kappaB, and strongly enhances transcription directed by these activat... | Sterol regulatory element-binding protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04852","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MED15 interacts with multiple genes. One interaction is supported by evidence stating: 'Here we show that this activator-recruited cofactor (ARC) int... | |
medium_divergent_branch_04853 | The gene AP4B1 interacts with multiple other genes. One specific interaction is supported by evidence stating: 'Similarly, two large subunits of the AP-4 complex, epsilon-adaptin and beta4-adaptin, are found to interact with each other only in the presence of the small subunit, sigma4.' Based on this evidence, which pr... | AP-4 complex subunit epsilon-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04853","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene AP4B1 interacts with multiple other genes. One specific interaction is supported by evidence stating: 'Similarly, two large subunits of the ... | |
medium_divergent_branch_04854 | MYCBP2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we report that two E3 ligases, Arf-bp1 and Pam (Myc-bp2), copurified with Rev-erb alpha and were required for its ubiquitination.' Which protein, connected to MYCBP2 via an interaction, is the subject of this specific evide... | Nuclear receptor subfamily 1 group D member 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04854","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MYCBP2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we report that two E3 ligases, Arf-bp1 and Pam (Myc-... | |
medium_divergent_branch_04856 | The alveolar type 1 fibroblast cell is a subtype of a specific cell type. Evidence indicates that this specific cell type is part of the alveolus and contains lipid droplets. Which anatomical structure is this specific cell type part of? | respiratory system | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04856","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The alveolar type 1 fibroblast cell is a subtype of a specific cell type. Evidence indicates that this specific cell type is part of the alveolus and... | |
medium_divergent_branch_04857 | GATA4 is associated with multiple biological processes. One association is supported by evidence stating: 'we suggest that GATA-6 might function primarily within the proliferating progenitor population, while GATA-4 and GATA-5 function during differentiation to activate terminal-differentiation genes including IFABP.' ... | digestive tract development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04857","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GATA4 is associated with multiple biological processes. One association is supported by evidence stating: 'we suggest that GATA-6 might function prim... | |
medium_divergent_branch_04859 | The gene JUND interacts with multiple partners. One of these partners is characterized by evidence stating that both it and JUND contain a docking domain that specifically binds JNKs. Which protein is encoded by this specific interacting partner? | Mitogen-activated protein kinase 8 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04859","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene JUND interacts with multiple partners. One of these partners is characterized by evidence stating that both it and JUND contain a docking do... | |
medium_divergent_branch_04860 | The protein RYBP interacts with multiple genes. One of these interacting partners has an interaction with RYBP that was confirmed by coimmunoprecipitation, GST pulldown, and immunofluorescence assays. Which disease is associated with this specific interacting gene? | asthma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04860","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein RYBP interacts with multiple genes. One of these interacting partners has an interaction with RYBP that was confirmed by coimmunoprecipit... |
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