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medium_divergent_branch_04862 | AP2B1 interacts with multiple genes. One specific interaction is characterized by evidence stating that AP2/TGF-beta receptor binding was mediated by a direct interaction between the beta2-adaptin N-terminal trunk domain and the cytoplasmic tails of the receptors. Which disease is associated with the gene involved in t... | nervous system disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04862","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AP2B1 interacts with multiple genes. One specific interaction is characterized by evidence stating that AP2/TGF-beta receptor binding was mediated by... | |
medium_divergent_branch_04863 | The IgM immunoglobulin complex is associated with multiple cell types via the plasma membrane. One of these cell types is characterized as an unswitched memory B cell with the phenotype IgM-positive and IgD-negative. Which cell type, connected to the IgM immunoglobulin complex through the plasma membrane, corresponds t... | IgD-negative memory B cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04863","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The IgM immunoglobulin complex is associated with multiple cell types via the plasma membrane. One of these cell types is characterized as an unswitc... | |
medium_divergent_branch_04864 | ANKHD1 interacts with multiple proteins. One specific interaction partner was identified through coimmunoprecipitation and/or bioluminescence resonance energy transfer (BRET) experiments, as part of a set of 11 proteins including CHMP5, SDCCAG3, TRIM41, LDOC1, PPP1R12C, DOCK7, VIM, KRT15, PPP2R3B, and C10Orf67. Which p... | Nucleotide-binding oligomerization domain-containing protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04864","source_qa_id":"medium_divergent_branch_05258","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ANKHD1 interacts with multiple proteins. One specific interaction partner was identified through ... | |
medium_divergent_branch_04865 | IFNG is associated with multiple biological processes. One such process is supported by evidence stating that ten months of IFN-gamma expression led to an increase in microglial activation. Which cell type serves as the primary input for this specific biological process? | microglial cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04865","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IFNG is associated with multiple biological processes. One such process is supported by evidence stating that ten months of IFN-gamma expression led ... | |
medium_divergent_branch_04866 | The gene BEX2 is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence stating: 'This study demonstrates that BEX2 has a significant role in the regulation of mitochondrial apoptosis and G1 cell cycle in breast cancer.' Identify the biologica... | regulation of programmed cell death | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04866","source_qa_id":"medium_divergent_branch_02482","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene BEX2 is associated with multiple biological processes via the 'involved in' relationship... | |
medium_divergent_branch_04867 | WNT10B is associated with multiple biological processes. One association is supported by evidence stating: 'These data indicate that the gene products of the Wnt family function as hematopoietic growth factors, and that they may exhibit higher specificity for earlier progenitor cells.' Which biological process is linke... | hemopoiesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04867","source_qa_id":"medium_divergent_branch_00825","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"WNT10B is associated with multiple biological processes. One association is supported by evidence... | |
medium_divergent_branch_04868 | NUP54 interacts with multiple proteins. One interaction is supported by evidence stating that a specific nuclear pore glycoprotein was associated with polypeptides of 58 and 54 kD (Finlay et al., 1991). Which protein, among those interacting with NUP54, is encoded by the gene corresponding to this evidence? | Nuclear pore glycoprotein p62 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04868","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NUP54 interacts with multiple proteins. One interaction is supported by evidence stating that a specific nuclear pore glycoprotein was associated wit... | |
medium_divergent_branch_04869 | Prosaposin (PSAP) is associated with multiple biological processes. One association is supported by evidence stating: 'We found that prosaposin (PSAP) interacts with PGRN and facilitates its lysosomal targeting in both biosynthetic and endocytic pathways via the cation-independent mannose 6-phosphate receptor and low d... | vacuolar transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04869","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Prosaposin (PSAP) is associated with multiple biological processes. One association is supported by evidence stating: 'We found that prosaposin (PSAP... | |
medium_divergent_branch_04870 | PAK4 interacts with multiple proteins. One specific interaction partner is described as a protein that interacts with the serine/threonine-protein kinase PAK4, which phosphorylates β-catenin to prevent its ubiquitin-proteasomal degradation. Which gene encodes this specific interaction partner? | PAK4-inhibitor INKA2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04870","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PAK4 interacts with multiple proteins. One specific interaction partner is described as a protein that interacts with the serine/threonine-protein ki... | |
medium_divergent_branch_04872 | AKAP9 interacts with multiple proteins. One interaction partner is linked to SMYLE via an evolutionarily conserved N-terminal domain and is anchored at the centrosome through CDK5RAP2. Which protein is encoded by the gene corresponding to this specific interaction partner? | Myomegalin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04872","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AKAP9 interacts with multiple proteins. One interaction partner is linked to SMYLE via an evolutionarily conserved N-terminal domain and is anchored ... | |
medium_divergent_branch_04873 | ADRM1 interacts with multiple proteins. One interaction partner is a proteasome base subunit that recruits ADRM1 via its C-terminal region, which binds to the ADRM1 Pru domain. Which protein product is encoded by this specific interaction partner? | 26S proteasome non-ATPase regulatory subunit 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04873","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ADRM1 interacts with multiple proteins. One interaction partner is a proteasome base subunit that recruits ADRM1 via its C-terminal region, which bin... | |
medium_divergent_branch_04874 | The gene DACH1 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 8.77 TPM, a z-score of 2.05, and a fold enrichment of 6.99. Which cell type corresponds to this specific expression profile, and what is its immediate parent category in the cell type hierarchy? | dendritic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04874","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene DACH1 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 8.77 TPM, a z-score of 2... | |
medium_divergent_branch_04875 | The intervertebral disk of the thoracic vertebra is a type of anatomy that connects to a broader anatomical category. Evidence for this classification describes the entity as an intervertebral disk that is part of the thoracic region of the vertebral column, connecting at least one thoracic vertebra to another thoracic... | cartilage element | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04875","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The intervertebral disk of the thoracic vertebra is a type of anatomy that connects to a broader anatomical category. Evidence for this classificatio... | |
medium_divergent_branch_04877 | GFAP interacts with multiple proteins. One interaction is supported by evidence stating: 'This provides GFAP epsilon with the capacity for specific binding of presenilin proteins in yeast and in vitro.' Which protein, connected to GFAP via this interaction, is encoded by the gene in question? | Presenilin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04877","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GFAP interacts with multiple proteins. One interaction is supported by evidence stating: 'This provides GFAP epsilon with the capacity for specific b... | |
medium_divergent_branch_04878 | HSPA9 interacts with multiple genes. One of these interactions is supported by evidence stating: 'We report that Aurora-A phosphorylation of a tumor suppressor protein at serine235 abrogates its transactivation function and causes cytoplasmic sequestration in a complex with the chaperon protein mortalin.' Which protein... | Tumor protein p73 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04878","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HSPA9 interacts with multiple genes. One of these interactions is supported by evidence stating: 'We report that Aurora-A phosphorylation of a tumor ... | |
medium_divergent_branch_04880 | Chromaffin cells are anatomically connected to more than one structure via a 'part of' relationship. One of these connections is supported by evidence stating: 'This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the... | chromaffin system | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04880","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Chromaffin cells are anatomically connected to more than one structure via a 'part of' relationship. One of these connections is supported by evidenc... | |
medium_divergent_branch_04881 | TRIM11 interacts with multiple proteins. One specific interaction is characterized by TRIM11 catalyzing the formation of K48-linked ubiquitin chains on the partner protein and promoting its degradation via the proteasome. Which protein, connected to TRIM11 through this specific interaction, is encoded by the gene in qu... | Lysine-specific demethylase 5C | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04881","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM11 interacts with multiple proteins. One specific interaction is characterized by TRIM11 catalyzing the formation of K48-linked ubiquitin chains ... | |
medium_divergent_branch_04882 | OS9 interacts with multiple proteins. One interaction is supported by evidence stating: 'Another MRH domain-containing ER lectin, hOS-9, is incorporated into this large complex, but gp78, another mammalian homolog of the yeast ubiquitin ligase Hrd1p, is not.' Which protein, connected to OS9 via this interaction, is enc... | Protein sel-1 homolog 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04882","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"OS9 interacts with multiple proteins. One interaction is supported by evidence stating: 'Another MRH domain-containing ER lectin, hOS-9, is incorpora... | |
medium_divergent_branch_04883 | Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.090 and an adjusted p-value of 0.0386. Which disease has a genomic-alteration link with that selected gene? | gestational diabetes | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04883","source_qa_id":"medium_divergent_branch_01588","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fo... | |
medium_divergent_branch_04884 | Blood microvessels are a type of anatomy. Evidence for one of its broader anatomical categories states: 'Any of the smallest blood vessels where blood circulates within organ tissues. Microvessels include terminal arterioles, metarterioles, capillaries, and venules (but exclude lymphatic capillaries). Arterioles carry ... | vasculature | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04884","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Blood microvessels are a type of anatomy. Evidence for one of its broader anatomical categories states: 'Any of the smallest blood vessels where bloo... | |
medium_divergent_branch_04885 | The gene CTNNA2 is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence stating that CTNNA2 is expressed in the human cerebral cortex and that its loss in neurons results in defects in neurite stability and migration. Which biological proces... | regulation of plasma membrane bounded cell projection organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04885","source_qa_id":"medium_divergent_branch_02105","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene CTNNA2 is associated with multiple biological processes via the 'involved in' relationsh... | |
medium_divergent_branch_04886 | MEOX2 interacts with multiple proteins. One specific interaction is supported by in vitro pull-down assays and co-immunoprecipitation studies in mammalian cells, which corroborated yeast two-hybrid data demonstrating that the interacting partner binds to MEOX2. Which protein, connected to MEOX2 via this specific intera... | E3 ubiquitin-protein ligase RNF10 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04886","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MEOX2 interacts with multiple proteins. One specific interaction is supported by in vitro pull-down assays and co-immunoprecipitation studies in mamm... | |
medium_divergent_branch_04887 | TERT interacts with multiple proteins. One of these interaction partners is reported to interact with TERT specifically during the G2/M phase of the cell cycle and to induce TERT degradation. Which protein is encoded by the gene corresponding to this specific interaction partner? | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04887","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TERT interacts with multiple proteins. One of these interaction partners is reported to interact with TERT specifically during the G2/M phase of the ... | |
medium_divergent_branch_04888 | RALBP1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using a yeast two-hybrid screening system, we have identified Ral-binding protein 1 (RalBP1) as an additional [protein]-interacting protein.' Which protein, connected to RALBP1 via this specific interaction, is encoded by the ge... | Heat shock factor protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04888","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RALBP1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using a yeast two-hybrid screening system, we have identi... | |
medium_divergent_branch_04889 | The gene PGR is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'In this study, we found that the E6-associated protein directly interacts with and coactivates the transcriptional activity of the human progesterone receptor (PR) in a hormone-dependent manner.' Which ... | Ubiquitin-protein ligase E3A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04889","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PGR is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'In this study, we found that th... | |
medium_divergent_branch_04890 | PINK1 interacts with multiple proteins. One specific interaction is described by the following evidence: 'We show that PINK1 specifically binds to TRAF6 and a kinase, and facilitates the autodimerization and autoubiquitination of TRAF6.' Which disease is associated with the gene encoding this kinase via genomic alterat... | cardiospondylocarpofacial syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04890","source_qa_id":"medium_divergent_branch_06894","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"PINK1 interacts with multiple proteins. One specific interaction is described by the following ev... | |
medium_divergent_branch_04891 | KRTCAP2 is reported to interact with multiple proteins. Experimental evidence from co-immunoprecipitation studies confirms a robust and specific physical interaction between KCP2 (the protein encoded by KRTCAP2) and a specific partner, while noting weaker associations with STT3B and OST48. Which protein, encoded by the... | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04891","source_qa_id":"medium_divergent_branch_01952","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"KRTCAP2 is reported to interact with multiple proteins. Experimental evidence from co-immunopreci... | |
medium_divergent_branch_04892 | The gene RGCC is associated with multiple biological processes. One specific association is supported by evidence stating: 'RGC-32 also stimulated apoptosis as shown by the increased apoptotic cells and caspase-3 cleavage.' Identify the biological process that is positively regulated by the specific process linked to R... | endothelial cell apoptotic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04892","source_qa_id":"medium_divergent_branch_04157","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene RGCC is associated with multiple biological processes. One specific association is suppo... | |
medium_divergent_branch_04893 | PRKCD interacts with multiple proteins. One interaction is supported by evidence stating: 'In a search for such proteins, protein kinase C-delta (PKC-delta) was found to coprecipitate in mast cells with a specific adaptor protein and to interact with its SH2 domain following antigen or pervanadate stimulation.' Which d... | malignant pancreatic neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04893","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRKCD interacts with multiple proteins. One interaction is supported by evidence stating: 'In a search for such proteins, protein kinase C-delta (PKC... | |
medium_divergent_branch_04894 | Hepatocyte growth factor (HGF) is associated with multiple biological processes. One specific association is supported by evidence stating: 'We previously reported that HGF and 1,25OHD act together to increase osteogenic differentiation of human MSC (hMSC) potentially through increasing p53.' Based on this evidence, id... | osteoblast differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04894","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Hepatocyte growth factor (HGF) is associated with multiple biological processes. One specific association is supported by evidence stating: 'We previ... | |
medium_divergent_branch_04895 | PDZRN3 interacts with multiple proteins. One of these interaction partners is specifically identified in experimental evidence as the substrate of PDZRN3, where PDZRN3 acts as an E3 ubiquitin ligase mediating the ubiquitination and degradation of this partner. Which protein is this interaction partner? | T-box transcription factor TBX20 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04895","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PDZRN3 interacts with multiple proteins. One of these interaction partners is specifically identified in experimental evidence as the substrate of PD... | |
medium_divergent_branch_04896 | EEF1D interacts with multiple genes. One of these interaction partners is involved in cooperative physical interactions with eEF1BδL and HSF1, which synergistically promote the expression of heat shock-responsive genes. Which disease is associated with this specific interaction partner? | ulcerative colitis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04896","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EEF1D interacts with multiple genes. One of these interaction partners is involved in cooperative physical interactions with eEF1BδL and HSF1, which ... | |
medium_divergent_branch_04898 | CLIC4 is associated with multiple biological processes. One specific process is supported by evidence stating that nuclear CLIC4 contributes to cell cycle arrest and the gene expression program associated with keratinocyte terminal differentiation. Which cell type is linked to this specific biological process via the '... | basal cell of epidermis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04898","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CLIC4 is associated with multiple biological processes. One specific process is supported by evidence stating that nuclear CLIC4 contributes to cell ... | |
medium_divergent_branch_04900 | FRS2 interacts with multiple proteins. One interaction partner is characterized by evidence stating that tyrosine-phosphorylated SNT binds to both p13suc1 protein and the SH2 domain of this partner. Which protein is encoded by the gene corresponding to this interaction partner? | Growth factor receptor-bound protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04900","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FRS2 interacts with multiple proteins. One interaction partner is characterized by evidence stating that tyrosine-phosphorylated SNT binds to both p1... | |
medium_divergent_branch_04901 | NCOA4 interacts with multiple proteins. Evidence for one of these interactions indicates that ubiquitin-dependent turnover of the interacting partner is promoted by excess iron and involves an iron-dependent interaction between NCOA4 and this partner, which functions as a ubiquitin ligase. Which protein, connected to N... | E3 ubiquitin-protein ligase HERC2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04901","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NCOA4 interacts with multiple proteins. Evidence for one of these interactions indicates that ubiquitin-dependent turnover of the interacting partner... | |
medium_divergent_branch_04903 | CRYAA interacts with multiple genes. One interaction is supported by evidence stating: 'Using GST pulldown assays and coimmunoprecipitations, we demonstrated that alpha-crystallins bind to Bax and a Bcl-2 family member both in vitro and in vivo.' Which disease is connected to the gene encoding this Bcl-2 family member ... | stroke disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04903","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CRYAA interacts with multiple genes. One interaction is supported by evidence stating: 'Using GST pulldown assays and coimmunoprecipitations, we demo... | |
medium_divergent_branch_04904 | JMJD6 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that the extraterminal (ET) domain, whose function has to date not been determined, interacts with NSD3, JMJD6, CHD4, GLTSCR1, and ATAD5.' Which protein, encoded by the gene corresponding to the interaction partner of JM... | Bromodomain-containing protein 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04904","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"JMJD6 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that the extraterminal (ET) domain, whose functio... | |
medium_divergent_branch_04905 | CRYAA interacts with multiple genes. One interaction is supported by evidence stating: 'Chloramphenicol acetyltransferase activity indicated that there were interactions between alphaA- (or alphaB-) and betaB2- or gammaC-crystallins but with an intensity of one-third that of alphaA-alphaB interactions.' Which biologica... | visual perception | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04905","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CRYAA interacts with multiple genes. One interaction is supported by evidence stating: 'Chloramphenicol acetyltransferase activity indicated that the... | |
medium_divergent_branch_04906 | The biological process 'regulation of cardiac muscle cell contraction' is a subtype of two distinct parent processes. One parent process is defined by the evidence: 'Any process that modulates the frequency, rate or extent of cardiac muscle cell contraction.' Which biological process is regulated by this specific paren... | cardiac muscle contraction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04906","source_qa_id":"medium_divergent_branch_03540","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'regulation of cardiac muscle cell contraction' is a subtype of two distin... | |
medium_divergent_branch_04908 | PDGFRA interacts with multiple proteins. One interaction is supported by evidence stating: 'We have identified two autophosphorylation sites, Tyr-988 and Tyr-1018, in the platelet-derived growth factor (PDGF) alpha-receptor carboxyl-terminal tail, which are involved in binding of phospholipase C-gamma (PLC-gamma).' Whi... | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04908","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PDGFRA interacts with multiple proteins. One interaction is supported by evidence stating: 'We have identified two autophosphorylation sites, Tyr-988... | |
medium_divergent_branch_04910 | EGR2 is associated with multiple biological processes. One of these processes is supported by evidence that Egr2(-/-) mice exhibit disrupted hindbrain segmentation and development. Which anatomical structure is the result of the development governed by this specific biological process? | brain | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04910","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EGR2 is associated with multiple biological processes. One of these processes is supported by evidence that Egr2(-/-) mice exhibit disrupted hindbrai... | |
medium_divergent_branch_04912 | MTG2 is associated with multiple cellular components via 'located in' relationships. One specific association is supported by evidence stating that Mtg1 and ObgH1 specifically associate with the large subunit of this component in a GTP-dependent manner. Which cellular component is a parent of this component in the 'is ... | organellar ribosome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04912","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MTG2 is associated with multiple cellular components via 'located in' relationships. One specific association is supported by evidence stating that M... | |
medium_divergent_branch_04913 | RCOR1 interacts with multiple genes. One of these interaction partners is described as interacting with CoREST in vitro and in vivo, functioning as an E3-ligase to mediate its sumoylation. Which gene, connected to RCOR1, is the subject of this description, and what gene does it bind to? | STAT4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04913","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RCOR1 interacts with multiple genes. One of these interaction partners is described as interacting with CoREST in vitro and in vivo, functioning as a... | |
medium_divergent_branch_04914 | NFKB1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The physical association of NF-kappa B with SF-1 was shown by yeast two-hybrid protein interaction, glutathione S-transferase pull-down, and coimmunoprecipitation (ChIP) analyses.' Which protein is encoded by the gene th... | Splicing factor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04914","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NFKB1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The physical association of NF-kappa B with SF-1 ... | |
medium_divergent_branch_04915 | CTNND1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'The protein-tyrosine phosphatase encoded by the interacting gene binds to and dephosphorylates p120 catenin.' Which protein is encoded by the gene that interacts with CTNND1 in this specific context? | Tyrosine-protein phosphatase non-receptor type 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04915","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CTNND1 interacts with multiple genes. One of these interactions is supported by evidence stating: 'The protein-tyrosine phosphatase encoded by the in... | |
medium_divergent_branch_04916 | IGF1R interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study, we demonstrate an association between the IGF-I receptor and p85, Syp, and a GTPase-activating protein, but not with PLC-gamma in lysates of cells overexpressing the human IGF-I receptor.' Which protein, encoded by... | Ras GTPase-activating protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04916","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IGF1R interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study, we demonstrate an association between the I... | |
medium_divergent_branch_04917 | KMT2A interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that this protein, a component of the ECS(ASB) E3 ubiquitin ligase complex, mediates MLL degradation through interaction with the PHD/Bromodomain region of MLL.' Which protein, connected to KMT2A via this interaction... | Ankyrin repeat and SOCS box protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04917","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KMT2A interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that this protein, a component of the ECS(ASB... | |
medium_divergent_branch_04918 | TULP3 is associated with multiple biological processes. One specific association is supported by evidence stating that TULP3 and IFT-A promote the trafficking of a subset of G protein-coupled receptors (GPCRs), but not Smoothened, to cilia. Which biological process, connected to the process described by this evidence v... | regulation of signal transduction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04918","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TULP3 is associated with multiple biological processes. One specific association is supported by evidence stating that TULP3 and IFT-A promote the tr... | |
medium_divergent_branch_04919 | The term 'upper back muscle' is a subclass of two distinct anatomical categories. One of these categories is defined as a muscle of the back that is part of a dorsal thoracic segment of the trunk. Which anatomical structure is the parent category of 'upper back muscle' that satisfies this definition? | musculature of thorax | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04919","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The term 'upper back muscle' is a subclass of two distinct anatomical categories. One of these categories is defined as a muscle of the back that is ... | |
medium_divergent_branch_04920 | Acetylcholine interacts with multiple drugs. One of these drugs is described by evidence stating: 'Inhaled agents that antagonize the muscarinic (M) acetylcholine receptor, particularly airway M3 receptors, have increasing data supporting use in persistent asthma.' Which disease is the drug described by this evidence i... | chronic obstructive pulmonary disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04920","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Acetylcholine interacts with multiple drugs. One of these drugs is described by evidence stating: 'Inhaled agents that antagonize the muscarinic (M) ... | |
medium_divergent_branch_04922 | USP51 interacts with multiple proteins. One interaction is supported by evidence stating: 'By screening a human deubiquitinase library, we identified USP51 as a deubiquitinase that binds, deubiquitinates, and stabilizes this interaction partner.' Which protein, connected to USP51 via this specific interaction evidence,... | Zinc finger E-box-binding homeobox 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04922","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP51 interacts with multiple proteins. One interaction is supported by evidence stating: 'By screening a human deubiquitinase library, we identified... | |
medium_divergent_branch_04923 | Methoxamine interacts with multiple drugs. One of these interacting drugs, when used in combination with adiponectin, was shown to further attenuate responses to adrenergic agonists by 65% in diabetic treated spontaneously hypertensive rats (SHRs), whereas adiponectin alone blunted these responses by 40%. Which disease... | type 2 diabetes mellitus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04923","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Methoxamine interacts with multiple drugs. One of these interacting drugs, when used in combination with adiponectin, was shown to further attenuate ... | |
medium_divergent_branch_04924 | HACE1 interacts with multiple proteins. One specific interaction partner is described as an E2 enzyme that HACE1 interacts with, in the context of HACE1 functioning as an E3 ligase that forms a thioester intermediate with ubiquitin and catalyzes ubiquitination without a cognate E2. Which disease is associated with this... | systemic lupus erythematosus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04924","source_qa_id":"medium_divergent_branch_07195","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"HACE1 interacts with multiple proteins. One specific interaction partner is described as an E2 en... | |
medium_divergent_branch_04926 | The gene PPP2R2A interacts with multiple other genes. One specific interaction is supported by evidence stating that PP2A associates with a specific kinase, but fails to associate with a mutated form of this kinase that is resistant to rapamycin- and amino acid deprivation-mediated dephosphorylation. Which protein is e... | Ribosomal protein S6 kinase beta-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04926","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PPP2R2A interacts with multiple other genes. One specific interaction is supported by evidence stating that PP2A associates with a specific ... | |
medium_divergent_branch_04927 | XCL1 is involved in multiple biological processes. One of these processes is supported by evidence stating that incubation with recombinant human XCL1 significantly increased Treg-mediated suppression and cytotoxicity. Which biological process is positively regulated by this specific XCL1-associated process? | T cell mediated cytotoxicity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04927","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"XCL1 is involved in multiple biological processes. One of these processes is supported by evidence stating that incubation with recombinant human XCL... | |
medium_divergent_branch_04928 | GRK2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The interactions of this protein and GRK2, as well as MMP-9 expression, were upregulated in response to TNF-α and PGE2 co-stimulation.' What is the name of the protein encoded by the gene corresponding to this interaction... | TNF receptor-associated factor 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04928","source_qa_id":"medium_divergent_branch_04152","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"GRK2 interacts with multiple proteins. One specific interaction is supported by evidence stating:... | |
medium_divergent_branch_04929 | RYR1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here, we demonstrate that Homer proteins also physically associate with ryanodine receptors type 1 and regulate gating responses to Ca(2+), depolarization, and caffeine.' Which disease is connected to the gene identified in ... | sensorineural hearing loss disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04929","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RYR1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here, we demonstrate that Homer proteins also physica... | |
medium_divergent_branch_04930 | The gene NF1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In cell-free systems, purified recombinant NF1-GRD mutants showed an inhibitory effect on the association of Ras.guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) with Raf at several times lower concentrations than the wil... | GTPase NRas | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04930","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene NF1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In cell-free systems, purified recombinant NF1-GRD ... | |
medium_divergent_branch_04931 | FBP1 interacts with multiple genes. One of these interacting partners has a reported interaction with FBP1 (or mTOR) that was validated using a co-immunoprecipitation assay. Which disease is associated with this specific interacting gene as a biomarker? | glioblastoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04931","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBP1 interacts with multiple genes. One of these interacting partners has a reported interaction with FBP1 (or mTOR) that was validated using a co-im... | |
medium_divergent_branch_04932 | SNAPIN is implicated in multiple biological processes. One line of evidence states: 'These results suggest that Snapin is an important component of the neurotransmitter release process through its modulation of the sequential interactions between the SNAREs and synaptotagmin.' Based on this specific evidence, which bio... | chemical synaptic transmission | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04932","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SNAPIN is implicated in multiple biological processes. One line of evidence states: 'These results suggest that Snapin is an important component of t... | |
medium_divergent_branch_04933 | TINF2 interacts with multiple proteins. One interaction is supported by evidence stating: 'We demonstrate that TIN2 binds to the interaction partner and is ubiquitylated in vivo.' Which protein, encoded by the gene connected to TINF2 via this specific interaction, is the subject of this evidence? | E3 ubiquitin-protein ligase SIAH2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04933","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TINF2 interacts with multiple proteins. One interaction is supported by evidence stating: 'We demonstrate that TIN2 binds to the interaction partner ... | |
medium_divergent_branch_04934 | GABARAPL1 interacts with multiple proteins. One specific interaction partner is characterized by the use of ATG8 family-interacting motifs to bind preferentially to GABARAP proteins. Which protein is encoded by the gene corresponding to this specific interaction partner? | Kelch repeat and BTB domain-containing protein 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04934","source_qa_id":"medium_divergent_branch_06178","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"GABARAPL1 interacts with multiple proteins. One specific interaction partner is characterized by ... | |
medium_divergent_branch_04935 | A lung-resident CD8 T cell subset is defined by its expression of granzyme K (GZMK) and tissue residency markers CD103 and CD49a. This cell exhibits cytotoxic potential through the expression of multiple granzymes (GZMA, GZMB, GZMH, GZMM) in addition to GZMK. Which broader cell type is this specific subset a subclass o... | lung resident memory CD8-positive, alpha-beta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04935","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"A lung-resident CD8 T cell subset is defined by its expression of granzyme K (GZMK) and tissue residency markers CD103 and CD49a. This cell exhibits ... | |
medium_divergent_branch_04936 | MIA3 interacts with multiple genes via binding interactions. One specific interaction is supported by evidence stating: 'The PRD binds to the COPII coat subunits, Sec23/24.' Which protein is encoded by the gene that corresponds to this specific binding partner? | Protein transport protein Sec23A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04936","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIA3 interacts with multiple genes via binding interactions. One specific interaction is supported by evidence stating: 'The PRD binds to the COPII c... | |
medium_divergent_branch_04937 | The protein CD300A is involved in multiple biological processes. One specific process is supported by evidence stating that cross-linking of IRp60 (CD300A) inhibits IgE-induced degranulation and stem cell factor-mediated survival through mechanisms involving tyrosine phosphorylation, phosphatase recruitment, and termin... | mast cell activation involved in immune response | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04937","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein CD300A is involved in multiple biological processes. One specific process is supported by evidence stating that cross-linking of IRp60 (C... | |
medium_divergent_branch_04938 | The protein EIF3H is associated with multiple biological processes. One association is supported by evidence stating: 'The eukaryotic initiation factor 3 (eIF3) plays an important role in translation initiation, acting as a docking site for several eIFs that assemble on the 40S ribosomal subunit. Dissociation takes pla... | metabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04938","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein EIF3H is associated with multiple biological processes. One association is supported by evidence stating: 'The eukaryotic initiation fact... | |
medium_divergent_branch_04939 | EYA2 interacts with multiple genes. One of these interaction partners has been shown to bind and stabilize the co-transcriptional regulator EYA2, a process that stimulates mesenchymal gene expression and suppresses IFNα/β, chemokines CXCL9/10, and antigen presentation machinery, driven by the AXL extracellular ligand G... | parkinsonian-pyramidal syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04939","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EYA2 interacts with multiple genes. One of these interaction partners has been shown to bind and stabilize the co-transcriptional regulator EYA2, a p... | |
medium_divergent_branch_04940 | The KIT protein is involved in multiple biological processes. One specific process is supported by evidence stating that KIT contributes to mast cell homing and cytokine generation. Which biological process is positively regulated by this specific KIT-associated process? | mast cell cytokine production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04940","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The KIT protein is involved in multiple biological processes. One specific process is supported by evidence stating that KIT contributes to mast cell... | |
medium_divergent_branch_04941 | XRN2 interacts with multiple genes. One of these interacting partners is described as being crucial for transcription termination and R-loop resolution. Which disease is associated with this specific interacting gene via a biomarker relationship? | Fanconi anemia complementation group A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04941","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"XRN2 interacts with multiple genes. One of these interacting partners is described as being crucial for transcription termination and R-loop resoluti... | |
medium_divergent_branch_04942 | NASP interacts with multiple proteins. One specific interaction is characterized by the binding of NASP to a partner protein in unstimulated bronchial epithelial cells, a mechanism that prevents the activation of partner-dependent kinases. Which protein corresponds to this specific interaction partner? | TNF receptor-associated factor 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04942","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NASP interacts with multiple proteins. One specific interaction is characterized by the binding of NASP to a partner protein in unstimulated bronchia... | |
medium_divergent_branch_04943 | ALDH3B1 is associated with multiple biological processes. One association is supported by evidence stating: 'The results detailed in this study support a pathophysiological role for ALDH3B1 in protecting cells from the damaging effects of oxidative stress.' Which biological process, connected to the process described b... | response to stress | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04943","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ALDH3B1 is associated with multiple biological processes. One association is supported by evidence stating: 'The results detailed in this study suppo... | |
medium_divergent_branch_04944 | NCKIPSD interacts with multiple genes. One of these interacting partners is described in the literature as a 'new mDia-interacting protein which is expressed ubiquitously.' Which disease is associated with this specific interacting gene? | autosomal dominant auditory neuropathy 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04944","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NCKIPSD interacts with multiple genes. One of these interacting partners is described in the literature as a 'new mDia-interacting protein which is e... | |
medium_divergent_branch_04945 | CCL21 is associated with multiple biological processes. One association is supported by evidence stating that in vitro, stimulated human neutrophils migrate in response to the CCR7 ligands CCL19 and CCL21. Which biological process is positively regulated by the specific process linked to CCL21 via this neutrophil migra... | neutrophil chemotaxis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04945","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CCL21 is associated with multiple biological processes. One association is supported by evidence stating that in vitro, stimulated human neutrophils ... | |
medium_divergent_branch_04946 | The gene NRXN1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'Our results show that NLGN1, both in soluble and membrane-bound forms, induces neurite outgrowth that depends on the interaction with NRXN1 and on activation of fibroblast growth factor receptor-... | plasma membrane bounded cell projection organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04946","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene NRXN1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'Our results show that NL... | |
medium_divergent_branch_04947 | FGF7 is associated with multiple biological processes. One specific association is supported by evidence stating that BrdU incorporation analysis suggests FGF-10, in contrast to FGF-7, is a modest proliferation factor for the lung epithelium. Which biological process is positively regulated by the process linked to FGF... | epithelial cell proliferation involved in lung morphogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04947","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FGF7 is associated with multiple biological processes. One specific association is supported by evidence stating that BrdU incorporation analysis sug... | |
medium_divergent_branch_04948 | The NBN gene interacts with multiple proteins. One of these interaction partners has been experimentally identified as a binding partner of the MRE11-RAD50-NBS1 (MRN) complex. Which protein, encoded by the gene connected to NBN via this specific interaction, is the subject of this finding? | Transcriptional regulator ATRX | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04948","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The NBN gene interacts with multiple proteins. One of these interaction partners has been experimentally identified as a binding partner of the MRE11... | |
medium_divergent_branch_04949 | NCK1 interacts with multiple genes. One of these interaction partners is supported by evidence stating that a protein kinase specifically binds to the middle SH3 domain of NCK. Which disease is associated with this specific interaction partner? | carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04949","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NCK1 interacts with multiple genes. One of these interaction partners is supported by evidence stating that a protein kinase specifically binds to th... | |
medium_divergent_branch_04950 | ACAT1 is associated with multiple cellular components via the 'located in' relationship. One association is supported by evidence stating: 'Pulse labeling followed by subcellular fractionation revealed that the T2 proteins in the fibroblasts from these patients are present in the mitochondria.' Which cellular component... | cytoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04950","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ACAT1 is associated with multiple cellular components via the 'located in' relationship. One association is supported by evidence stating: 'Pulse lab... | |
medium_divergent_branch_04951 | The Aryl hydrocarbon receptor (AHR) interacts with multiple proteins. One specific interaction was confirmed in both a cell-free system and in mammalian cells using co-immunoprecipitation. Which protein is encoded by the gene that corresponds to this specific interacting partner? | Ubiquitin-like protein NEDD8 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04951","source_qa_id":"medium_divergent_branch_02496","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The Aryl hydrocarbon receptor (AHR) interacts with multiple proteins. One specific interaction wa... | |
medium_divergent_branch_04952 | Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.430 and an adjusted p-value of 0.0493. Which disease has a genomic-alteration link with that selected gene? | major depressive disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04952","source_qa_id":"medium_divergent_branch_03310","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showe... | |
medium_divergent_branch_04953 | MARK4 is known to bind to multiple gene products. One specific interaction involves a mother centriolar protein, where evidence indicates that this protein's localization to the centriole partially depends on MARK4. Which gene product does this specific MARK4-binding partner interact with? | ODF2L | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04953","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MARK4 is known to bind to multiple gene products. One specific interaction involves a mother centriolar protein, where evidence indicates that this p... | |
medium_divergent_branch_04954 | PTK2B interacts with multiple proteins. One interaction is supported by evidence stating: 'We have identified a new Pyk2 binding protein designated [a specific protein].' Which protein, connected to PTK2B via this specific interaction, is the subject of the 'encodes' relation? | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04954","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PTK2B interacts with multiple proteins. One interaction is supported by evidence stating: 'We have identified a new Pyk2 binding protein designated [... | |
medium_divergent_branch_04955 | The biological process 'regulation of amino acid biosynthetic process' is defined as any process that modulates the frequency, rate, or extent of cellular amino acid biosynthetic processes. This process is a subtype of two broader biological processes. One of these parent processes is specifically concerned with the re... | regulation of primary metabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04955","source_qa_id":"medium_divergent_branch_04188","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'regulation of amino acid biosynthetic process' is defined as any process ... | |
medium_divergent_branch_04956 | CARD10 interacts with multiple proteins. One of these interactions is characterized by the following evidence: 'When expressed in cells, CARD10 binds to this partner and signals the activation of NF-kappaB through its N-terminal effector CARD domain.' Which protein, connected to CARD10 via this specific interaction, is... | B-cell lymphoma/leukemia 10 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04956","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CARD10 interacts with multiple proteins. One of these interactions is characterized by the following evidence: 'When expressed in cells, CARD10 binds... | |
medium_divergent_branch_04957 | hsa-miR-145-5p regulates more than one type of cell. Evidence for one of these regulatory connections cites a study analyzing 84 microRNA expression levels in CD4(+) and CD8(+) T cells of patients with aplastic anemia, which revealed concurrent down-regulation of miR-126-3p, miR-145-5p, miR-223-3p, and miR-199a-5p (>3-... | mature alpha-beta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04957","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"hsa-miR-145-5p regulates more than one type of cell. Evidence for one of these regulatory connections cites a study analyzing 84 microRNA expression ... | |
medium_divergent_branch_04958 | HIF1A is associated with multiple biological processes. One association is supported by the statement: 'A central means by which mammalian cells respond to low oxygen tension is through the activation of the transcription factor HIF-1.' Identify the parent biological process (via an 'is a' relationship) of the specific... | intracellular chemical homeostasis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04958","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HIF1A is associated with multiple biological processes. One association is supported by the statement: 'A central means by which mammalian cells resp... | |
medium_divergent_branch_04959 | CAP1 interacts with multiple genes. One interaction is supported by evidence stating: 'We discovered two proteins, p65 and p55, that are components of the actin-cofilin complex in a human HEK293 cell extract and identified p55 as CAP1/ASP56, a human homologue of yeast CAP/SRV2 (cyclase-associated protein).' Which prote... | Cofilin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04959","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CAP1 interacts with multiple genes. One interaction is supported by evidence stating: 'We discovered two proteins, p65 and p55, that are components o... | |
medium_divergent_branch_04960 | SGK3 interacts with multiple genes. One of these interacting partners has an association with SGK3 that is confirmed independently in human embryonic kidney (HEK293) cells by co-immunoprecipitation. Which disease is associated with this specific interacting gene? | telangiectasis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04960","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SGK3 interacts with multiple genes. One of these interacting partners has an association with SGK3 that is confirmed independently in human embryonic... | |
medium_divergent_branch_04961 | The protein SRF is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'We demonstrate that full length Nkx3.1 physically interacts with SRF in the absence of DNA and that these factors are able to co-associate in cellular context using... | transcription factor binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04961","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein SRF is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence sta... | |
medium_divergent_branch_04962 | The gene TRAV1-1 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 25.84 TPM, a z-score of 1.54, and a fold enrichment of 4.33. Which cell type, connected to TRAV1-1 via this enrichment evidence, is a subtype of mature alpha-beta T cells? | mature alpha-beta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04962","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TRAV1-1 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 25.84 TPM, a z-score o... | |
medium_divergent_branch_04963 | The gene CDKN2A is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'To understand the mechanism of ARF-mediated tumor suppression, we identified a ubiquitin ligase, ARF-BP1, as a key factor associated with ARF in vivo.' Which protein, encoded by the gene that interac... | E3 ubiquitin-protein ligase HUWE1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04963","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CDKN2A is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'To understand the mechanism ... | |
medium_divergent_branch_04964 | COPS5 interacts with multiple proteins. One specific interaction is described by the following evidence: 'The association of CSN5 and the MPN domain of its interacting partner activates its isopeptidase activity.' Which protein product is encoded by the gene corresponding to the interacting partner mentioned in this ev... | COP9 signalosome complex subunit 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04964","source_qa_id":"medium_divergent_branch_02540","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"COPS5 interacts with multiple proteins. One specific interaction is described by the following ev... | |
medium_divergent_branch_04965 | ARFGEF2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Coimmunoprecipitation experiments confirmed interaction of in vitro translated BIG2 and RI alpha, as well as of the endogenous proteins in cytosol of cultured HepG2 cells.' Which protein, connected to ARFGEF2 via this ... | cAMP-dependent protein kinase type I-alpha regulatory subunit | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04965","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARFGEF2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Coimmunoprecipitation experiments confirmed int... | |
medium_divergent_branch_04966 | HOXA1 is implicated in multiple biological processes. One such process is supported by evidence describing a phenotype that includes horizontal gaze abnormalities, deafness, facial weakness, hypoventilation, vascular malformations of the internal carotid arteries and cardiac outflow tract, mental retardation, and autis... | ear development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04966","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HOXA1 is implicated in multiple biological processes. One such process is supported by evidence describing a phenotype that includes horizontal gaze ... | |
medium_divergent_branch_04969 | SOX9 is involved in multiple biological processes. One of these processes is supported by evidence stating: 'In murine embryonic prostate epithelia, the transcription factor SOX9 is required for proper prostate development.' Which anatomical structure is the result of the development process described in this evidence? | prostate gland | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04969","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SOX9 is involved in multiple biological processes. One of these processes is supported by evidence stating: 'In murine embryonic prostate epithelia, ... | |
medium_divergent_branch_04970 | BCL3 is involved in multiple biological processes. One such process is supported by evidence that transient expression of Bcl-3 potently inhibits virus-inducible IL-8 transcription by disrupting both the NF-kappaB and STAT/IRF pathways. Which biological process is negatively regulated by this specific BCL3-associated p... | interleukin-8 production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04970","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BCL3 is involved in multiple biological processes. One such process is supported by evidence that transient expression of Bcl-3 potently inhibits vir... | |
medium_divergent_branch_04971 | The gene HABP4 interacts with multiple partners. One interaction is supported by evidence stating: 'Through immunoprecipitation assays, we verified the association of Ki-1/57 with the endogenous splicing proteins hnRNPQ and a specific serine/arginine-rich splicing factor in HeLa cell extracts.' Which protein is encoded... | Serine/arginine-rich splicing factor 9 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04971","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene HABP4 interacts with multiple partners. One interaction is supported by evidence stating: 'Through immunoprecipitation assays, we verified t... | |
medium_divergent_branch_04972 | DAXX interacts with multiple proteins. Evidence for one specific interaction states: 'Its recruitment to ND10 from condensed chromatin requires a small ubiquitin-related modifier (SUMO-1) modification of the interaction partner and reflects the interaction between the COOH-terminal domain of DAXX and this partner.' Whi... | Protein PML | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04972","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DAXX interacts with multiple proteins. Evidence for one specific interaction states: 'Its recruitment to ND10 from condensed chromatin requires a sma... | |
medium_divergent_branch_04973 | IL22 interacts with multiple proteins. One interaction is supported by evidence stating: 'Each chain, [Protein A] and IL-10R2, is capable of binding IL-TIF independently and can be cross-linked to the radiolabeled IL-TIF.' Which protein, connected to IL22 via this specific binding evidence, is encoded by the gene in qu... | Interleukin-22 receptor subunit alpha-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04973","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IL22 interacts with multiple proteins. One interaction is supported by evidence stating: 'Each chain, [Protein A] and IL-10R2, is capable of binding ... | |
medium_divergent_branch_04974 | Interleukin-13 (IL13) is associated with multiple biological processes. One association is supported by evidence showing that treatment of differentiated human bronchial epithelial cell (HBEC) cultures with IL-13, a key mediator in asthma, increases goblet cell numbers and decreases ciliated cell numbers. Which biologi... | lung goblet cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04974","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Interleukin-13 (IL13) is associated with multiple biological processes. One association is supported by evidence showing that treatment of differenti... |
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