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medium_divergent_branch_04975 | The gene RRAGB is known to interact with multiple partners. One specific interaction involves a lysosomal transmembrane protein that shares sequence similarity with amino acid transporters and binds to Rag GTPases and Ragulator in an amino acid-sensitive manner. Which protein is encoded by the gene corresponding to thi... | Neutral amino acid transporter 9 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04975","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene RRAGB is known to interact with multiple partners. One specific interaction involves a lysosomal transmembrane protein that shares sequence ... | |
medium_divergent_branch_04976 | ADRB3 is involved in multiple biological processes. One such process is supported by evidence stating that, unlike beta(2)AR and beta(3)AR which regulate adenylyl cyclase and extracellular signal-regulated kinase activity via G(s) and G(i/o) coupling, no G(i/o) coupling was observed for the beta(2/3)AR hetero-oligomer.... | G protein-coupled receptor signaling pathway | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04976","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ADRB3 is involved in multiple biological processes. One such process is supported by evidence stating that, unlike beta(2)AR and beta(3)AR which regu... | |
medium_divergent_branch_04977 | The gene PPP2R5A interacts with multiple other genes. One specific interaction is supported by evidence stating: 'The interaction between B56alpha and a specific kinase was confirmed by in vitro binding assays as well as by in vivo coimmunoprecipitation, and this interaction is dependent on the catalytic activity of th... | Interferon-induced, double-stranded RNA-activated protein kinase | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04977","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PPP2R5A interacts with multiple other genes. One specific interaction is supported by evidence stating: 'The interaction between B56alpha an... | |
medium_divergent_branch_04978 | ADRB2 is associated with multiple cellular components via the 'located in' relationship. One of these associations is supported by evidence stating: 'The ability of the closely related beta(2)- and beta(3)-adrenergic receptors (AR) to form hetero-oligomers was assessed by bioluminescence resonance energy transfer.' Whi... | protein-containing complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04978","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ADRB2 is associated with multiple cellular components via the 'located in' relationship. One of these associations is supported by evidence stating: ... | |
medium_divergent_branch_04979 | POLA1 interacts with multiple genes. One of these interaction partners is supported by evidence showing that DNA polymerase alpha specifically bound to a purified protein-immobilized Sepharose column. Which cell type is the gene corresponding to this specific evidence enriched in? | naive B cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04979","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"POLA1 interacts with multiple genes. One of these interaction partners is supported by evidence showing that DNA polymerase alpha specifically bound ... | |
medium_divergent_branch_04980 | The gene CYLD interacts with multiple partners. One specific interaction is supported by evidence stating: 'Our results from co-immunoprecipitation (co-IP) and confocal microscopy assays confirmed a direct association between CYLD and TRAF-6 in A549 cells.' Which disease is associated with the interaction partner ident... | bone resorption disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04980","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CYLD interacts with multiple partners. One specific interaction is supported by evidence stating: 'Our results from co-immunoprecipitation (... | |
medium_divergent_branch_04981 | The gene ICOS is linked via a binding interaction to multiple other genes. One specific connection is supported by evidence stating: 'Interaction between inducible costimulator and its ligand is implicated in the induction of cell-mediated and humoral immune responses.' Which protein is encoded by the gene connected to... | ICOS ligand | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04981","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ICOS is linked via a binding interaction to multiple other genes. One specific connection is supported by evidence stating: 'Interaction bet... | |
medium_divergent_branch_04982 | CENPC interacts with multiple proteins. One of these interaction partners has been experimentally observed to localize at centromeres and physically associate with CENP-C, an integral component of the kinetochore. Which protein corresponds to this interaction partner? | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04982","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CENPC interacts with multiple proteins. One of these interaction partners has been experimentally observed to localize at centromeres and physically ... | |
medium_divergent_branch_04984 | The gene AP3S1 is known to interact with multiple partners. One specific interaction is described by the evidence: 'Here, we report an interdomain interaction involving the ear domain of the delta subunit and the sigma3 subunit of AP-3.' Based on this description, which protein is encoded by the gene that interacts wit... | AP-3 complex subunit delta-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04984","source_qa_id":"medium_divergent_branch_01211","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene AP3S1 is known to interact with multiple partners. One specific interaction is described... | |
medium_divergent_branch_04985 | The gene NPPA is reported to interact with multiple proteins. One specific interaction is supported by evidence describing the determination of crystal structures for complexes involving NPR-C, atrial natriuretic peptide (ANP), and brain natriuretic peptide (BNP) to elucidate binding specificity. Which protein is encod... | Atrial natriuretic peptide receptor 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04985","source_qa_id":"medium_divergent_branch_06008","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene NPPA is reported to interact with multiple proteins. One specific interaction is support... | |
medium_divergent_branch_04986 | KLHL3 interacts with multiple proteins. One specific interaction is characterized by the determination of the crystal structure of the KLHL3 Kelch domain in complex with a peptide from the interacting partner. Which protein, connected to KLHL3 via this interaction, is encoded by the gene in question? | Serine/threonine-protein kinase WNK3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04986","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KLHL3 interacts with multiple proteins. One specific interaction is characterized by the determination of the crystal structure of the KLHL3 Kelch do... | |
medium_divergent_branch_04987 | Lipoic acid is reported to interact with multiple drugs. One specific interaction is supported by evidence describing the beneficial effects of the interacting drug and α-lipoic acid in patients with polycystic ovary syndrome. Which disease is this specific interacting drug indicated for? | type 2 diabetes mellitus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04987","source_qa_id":"medium_divergent_branch_03152","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"Lipoic acid is reported to interact with multiple drugs. One specific interaction is supported by... | |
medium_divergent_branch_04988 | PAIP1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we show that the E6AP carboxyl terminus (HECT)-type ubiquitin ligase WW domain-containing protein 2, a homolog of the HECT-type ubiquitin ligase WWP1, interacts with and targets PAIP1 for ubiquitination and proteasomal degr... | NEDD4-like E3 ubiquitin-protein ligase WWP2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04988","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PAIP1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we show that the E6AP carboxyl terminus (HECT)-type ... | |
medium_divergent_branch_04989 | HRAS is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'We searched for proteins that interact with Ras in interleukin (IL)-2-stimulated or IL-2-deprived cells, and found that the transcription factor encoded by the gene interacting with HRAS interacts with Ras.' Wh... | Zinc finger protein Aiolos | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04989","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HRAS is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'We searched for proteins that interact ... | |
medium_divergent_branch_04990 | hsa-miR-181c-5p regulates more than one cell type. Evidence for one of these regulatory connections highlights the importance of miR-181 in the function of this cell type and the potential role of BRK1 in the involvement of the WAVE2 complex and actin polymerization within these cells, leading to an investigation of th... | pro-T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04990","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"hsa-miR-181c-5p regulates more than one cell type. Evidence for one of these regulatory connections highlights the importance of miR-181 in the funct... | |
medium_divergent_branch_04992 | SOX2 is associated with multiple biological processes. One association is supported by evidence that knockdown of SOX2 reduces the expression of key stem cell factors, including Oct4 and Nanog, thereby linking these factors in a pluripotent regulatory network. Which biological process, connected to the process supporte... | regulation of macromolecule biosynthetic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04992","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SOX2 is associated with multiple biological processes. One association is supported by evidence that knockdown of SOX2 reduces the expression of key ... | |
medium_divergent_branch_04993 | UBE2E2 interacts with multiple proteins. One interaction was identified in a yeast two-hybrid screening study that reported the identification of two RING-finger proteins, ARA54 and the interacting partner. Which disease is associated with this interacting partner as a biomarker? | Fanconi anemia complementation group A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04993","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBE2E2 interacts with multiple proteins. One interaction was identified in a yeast two-hybrid screening study that reported the identification of two... | |
medium_divergent_branch_04995 | MTOR interacts with multiple genes. One of these interactions is supported by evidence showing that Oncogenic Ras directly binds to two components of the mTOR complex 2 (mTORC2)—specifically MTOR and MAPKAP1—to promote mTORC2 kinase activity at the plasma membrane. Which disease is connected to this specific interactin... | renal fibrosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04995","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MTOR interacts with multiple genes. One of these interactions is supported by evidence showing that Oncogenic Ras directly binds to two components of... | |
medium_divergent_branch_04996 | APPL1 is associated with multiple biological processes. One association is supported by evidence stating: 'We show that APPL1 knockdown suppressed Akt phosphorylation, glucose uptake, and Glut4 translocation.' Which biological process, connected to the process supported by this evidence via a 'regulates' relationship, ... | D-glucose import across plasma membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04996","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"APPL1 is associated with multiple biological processes. One association is supported by evidence stating: 'We show that APPL1 knockdown suppressed Ak... | |
medium_divergent_branch_04997 | CARD11 interacts with multiple proteins. One interaction is supported by evidence stating: 'Furthermore, PKCbeta interacted with the serine-rich CARMA1 linker, and both PKCbeta and PKCtheta phosphorylated identical serine residues (S564, S649, and S657) within this linker.' Which protein, connected to CARD11 via a bind... | Protein kinase C theta type | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04997","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CARD11 interacts with multiple proteins. One interaction is supported by evidence stating: 'Furthermore, PKCbeta interacted with the serine-rich CARM... | |
medium_divergent_branch_04999 | Caffeine interacts with multiple drugs. One of these interacting drugs is a fluoroquinolone, and evidence indicates that interactions between fluoroquinolones and drugs metabolized by the hepatic cytochrome P450 system affect the clearance of caffeine. Which disease is the drug that interacts with caffeine (and fits th... | cervicitis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_04999","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Caffeine interacts with multiple drugs. One of these interacting drugs is a fluoroquinolone, and evidence indicates that interactions between fluoroq... | |
medium_divergent_branch_05001 | BRCA2 interacts with multiple proteins. One such interaction involves a protein that, upon activation by DNA damage, undergoes monoubiquitination. This modification is required for the protein's targeting to chromatin, where it physically interacts with BRCA2. Which protein, connected to BRCA2 via this interaction, is ... | Fanconi anemia group D2 protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05001","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BRCA2 interacts with multiple proteins. One such interaction involves a protein that, upon activation by DNA damage, undergoes monoubiquitination. Th... | |
medium_divergent_branch_05002 | ARIH2 interacts with multiple genes. One of these interaction partners is supported by evidence stating that Triad1 binds the E2 ubiquitin-conjugating enzyme encoded by UBE2L3, as well as ubiquitinated proteins, and supports the formation of ubiquitin chains recognized by the proteasome. Which protein is encoded by the... | Ubiquitin-conjugating enzyme E2 L3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05002","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARIH2 interacts with multiple genes. One of these interaction partners is supported by evidence stating that Triad1 binds the E2 ubiquitin-conjugatin... | |
medium_divergent_branch_05003 | ITGAV is associated with multiple biological processes. One association is supported by evidence stating that conditional short hairpin RNA-mediated knockdown of ITGA5 and ITGAV disrupted human embryonic stem cell (hESC) differentiation toward definitive endoderm (DE). Which biological process, connected to the process... | endoderm formation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05003","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ITGAV is associated with multiple biological processes. One association is supported by evidence stating that conditional short hairpin RNA-mediated ... | |
medium_divergent_branch_05004 | ABCA1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Cell surface coimmunoprecipitation with COS1 cells expressing extracellularly hemagglutinin-tagged ABCA1 showed that LXRβ interacted with ABCA1 and inhibited the ubiquitination of ABCA1.' Which disease is associated with... | anxiety | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05004","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ABCA1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Cell surface coimmunoprecipitation with COS1 cell... | |
medium_divergent_branch_05005 | MAP1B interacts with multiple proteins. One interaction partner is described as translocating from the nucleus to the cytoplasm during neuritogenesis, interacting with the light chain of microtubule-associated protein 1B, and modulating MAP1B's effects on neurite extension. Which protein, encoded by the gene connected ... | Acidic leucine-rich nuclear phosphoprotein 32 family member A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05005","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP1B interacts with multiple proteins. One interaction partner is described as translocating from the nucleus to the cytoplasm during neuritogenesis... | |
medium_divergent_branch_05006 | BMP6 interacts with multiple receptor genes. One specific interaction is supported by evidence stating: 'In addition, BMP-6 weakly bound to BMPR-IA (ALK-3), to which BMP-2 also bound.' Identify the disease causally linked to the gene described in this evidence. | CREST syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05006","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BMP6 interacts with multiple receptor genes. One specific interaction is supported by evidence stating: 'In addition, BMP-6 weakly bound to BMPR-IA (... | |
medium_divergent_branch_05007 | Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.458 and an adjusted p-value of 0.0422. Which disease is associated with that selected gene? | fibrosarcoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05007","source_qa_id":"medium_divergent_branch_06388","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showe... | |
medium_divergent_branch_05008 | STK38 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that both hMOB2 and hMOB1A bound to the N-terminal region of NDR1.' Which protein, connected to STK38 via an interaction, is the subject of this specific binding evidence? | MOB kinase activator 1A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05008","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"STK38 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that both hMOB2 and hMOB1A bound to the N-termina... | |
medium_divergent_branch_05010 | TERF2IP is known to interact with multiple proteins. One specific interaction partner co-localizes with a subset of telomeres in ALT-positive U2OS cells and interacts with TRF2/RAP1 via the N-terminal region of TRF2. Which protein is encoded by the gene corresponding to this specific interaction partner? | Zinc finger and BTB domain-containing protein 10 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05010","source_qa_id":"medium_divergent_branch_07424","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"TERF2IP is known to interact with multiple proteins. One specific interaction partner co-localize... | |
medium_divergent_branch_05011 | The gene EIF2B2 is associated with multiple biological processes. One association is supported by clinical evidence stating: 'Recently, in seven patients who presented with POF and white matter abnormalities on MRI (ovarioleukodystrophy) eight mutations were found in EIF2B2, 4 and 5.' Identify the biological process li... | female gonad development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05011","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene EIF2B2 is associated with multiple biological processes. One association is supported by clinical evidence stating: 'Recently, in seven pati... | |
medium_divergent_branch_05012 | Macrophage migration inhibitory factor (MIF) interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we report that the [protein encoded by NME1] interacts with MIF in cells, as demonstrated by cotransfection and coimmunoprecipitation experiments.' Which protein is encoded by ... | Nucleoside diphosphate kinase A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05012","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Macrophage migration inhibitory factor (MIF) interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we re... | |
medium_divergent_branch_05014 | Human polyomavirus 2 upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.149 and an adjusted p-value of 0.0447. Which protein does that selected gene encode? | Transmembrane protein 255A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05014","source_qa_id":"medium_divergent_branch_00052","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human polyomavirus 2 upregulates several genes. In the recorded experiment, one branch showed ... | |
medium_divergent_branch_05015 | IRF2BP2 interacts with multiple proteins. One specific interaction is described as follows: 'Here, we identified a transcriptional repressor, interferon regulatory factor 2 binding protein 2 (IRF-2BP2), which specifically interacts with the C-terminal domain of a member of the NFAT family among the NFAT family members.... | Nuclear factor of activated T-cells, cytoplasmic 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05015","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IRF2BP2 interacts with multiple proteins. One specific interaction is described as follows: 'Here, we identified a transcriptional repressor, interfe... | |
medium_divergent_branch_05016 | CDK19 interacts with multiple genes. One interaction is supported by evidence stating: 'We checked the reading frames of the candidate clones and obtained three positive clones, all of which encoded the transcriptional cofactors, Brahma-related gene 1, B-cell CLL/lymphoma 6 and suppressor of zeste 12 homolog.' Which pr... | B-cell lymphoma 6 protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05016","source_qa_id":"medium_divergent_branch_02713","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"CDK19 interacts with multiple genes. One interaction is supported by evidence stating: 'We checke... | |
medium_divergent_branch_05017 | AFF1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here we show that the AF4/FMR2 family member 1 (AFF1) is bound to CDK9-CycT and is present in all major P-TEFb complexes.' Which disease is associated with the gene identified in this specific interaction context? | nasopharyngeal carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05017","source_qa_id":"medium_divergent_branch_01776","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"AFF1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'H... | |
medium_divergent_branch_05018 | RPS3 interacts with multiple proteins. One interaction is supported by a study on radioresistance in non-small cell lung cancer (NSCLC), which found that ionizing radiation led to casein kinase 2α (CK2α)- and PKC-mediated phosphorylation of RPS3 and a specific partner protein, respectively. This phosphorylation induced... | TNF receptor-associated factor 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05018","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RPS3 interacts with multiple proteins. One interaction is supported by a study on radioresistance in non-small cell lung cancer (NSCLC), which found ... | |
medium_divergent_branch_05019 | Corticotropin-releasing hormone (CRH) interacts with multiple proteins. One specific interaction is supported by evidence describing three crystal structures of the human CRFR1 extracellular domain, including ligand-free and CRF-bound states. Which protein is encoded by the gene corresponding to this specific binding p... | Corticotropin-releasing factor receptor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05019","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Corticotropin-releasing hormone (CRH) interacts with multiple proteins. One specific interaction is supported by evidence describing three crystal st... | |
medium_divergent_branch_05020 | FOXH1 interacts with multiple genes. One of these interaction partners is a cytoplasmic protein that translocates to the nucleus upon TGF-beta stimulation and forms a multimeric complex with FAST-1 and another partner on the activin response element, a high-affinity binding site for FAST-1. Which disease is associated ... | cervical carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05020","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FOXH1 interacts with multiple genes. One of these interaction partners is a cytoplasmic protein that translocates to the nucleus upon TGF-beta stimul... | |
medium_divergent_branch_05021 | ARIH1 interacts with multiple proteins. One interaction partner is identified as the human homologue of Drosophila ariadne (HHARI), a RING-IBR-RING domain protein characterized by its ability to bind a specific human ubiquitin-conjugating enzyme. Which protein, encoded by the gene interacting with ARIH1 in this specifi... | Ubiquitin-conjugating enzyme E2 L3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05021","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARIH1 interacts with multiple proteins. One interaction partner is identified as the human homologue of Drosophila ariadne (HHARI), a RING-IBR-RING d... | |
medium_divergent_branch_05022 | The SNCA gene interacts with multiple partners. One specific interaction is supported by evidence stating: 'We demonstrated that this partner binds to both WT and the mutant form A30P asyn in an SH-SY5Y cell model.' Which disease is associated with this specific interacting partner? | bone resorption disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05022","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The SNCA gene interacts with multiple partners. One specific interaction is supported by evidence stating: 'We demonstrated that this partner binds t... | |
medium_divergent_branch_05023 | L3MBTL1 interacts with multiple genes. One of these interaction partners is part of a complex with Cdc45 and PCNA, which are components of the DNA replication machinery, and this partner is required for normal replication fork progression. Which disease is associated with this specific interaction partner? | autosomal dominant nonsyndromic hearing loss 70 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05023","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"L3MBTL1 interacts with multiple genes. One of these interaction partners is part of a complex with Cdc45 and PCNA, which are components of the DNA re... | |
medium_divergent_branch_05024 | PDHA1 interacts with multiple genes. One of these interacting partners is inhibited by K202 acetylation, a modification that causes the dissociation of its substrate, PDHA1. Which gene, among those interacting with PDHA1, is the one described by this regulatory mechanism, and what gene does it bind to? | PDPR | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05024","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PDHA1 interacts with multiple genes. One of these interacting partners is inhibited by K202 acetylation, a modification that causes the dissociation ... | |
medium_divergent_branch_05025 | The gene ACVRL1 is associated with multiple biological processes. One association is supported by the finding that 'ALK1 signaling regulates the differentiation of lymphatic endothelial cells to influence the lymphatic vascular development and remodeling.' Identify the biological process described by this evidence, and... | endothelial cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05025","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ACVRL1 is associated with multiple biological processes. One association is supported by the finding that 'ALK1 signaling regulates the diff... | |
medium_divergent_branch_05026 | ERBB2 is known to bind to multiple proteins. One of these binding partners interacts with a protein kinase, an interaction that increases the kinase's intrinsic activity. Which protein, encoded by the gene corresponding to this specific binding partner, is the target of the 'encodes' relationship? | Protein-tyrosine kinase 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05026","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ERBB2 is known to bind to multiple proteins. One of these binding partners interacts with a protein kinase, an interaction that increases the kinase'... | |
medium_divergent_branch_05027 | The parasympathetic nervous system is classified under multiple anatomical categories via the 'is a' relationship. One such classification is supported by the following evidence: 'The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cra... | multicellular anatomical structure | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05027","source_qa_id":"medium_divergent_branch_06265","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The parasympathetic nervous system is classified under multiple anatomical categories via the 'is... | |
medium_divergent_branch_05028 | mmu-miR-135a-5p regulates more than one cell type. Evidence for one of these regulatory connections indicates that MiR-135a strongly suppresses the infiltration of the target cell type and eosinophils into the nasal mucosa, and that the miRNA is specifically localized within these target cells, suggesting its influence... | mast cell progenitor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05028","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"mmu-miR-135a-5p regulates more than one cell type. Evidence for one of these regulatory connections indicates that MiR-135a strongly suppresses the i... | |
medium_divergent_branch_05029 | IFNL1 is associated with multiple biological processes. One association is supported by evidence stating that IFN-lambda1 diminished the change in cell-surface phenotype accompanying the differentiation of 'central memory' T cells into 'effector memory' T cells. Which biological process is negatively regulated by the p... | memory T cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05029","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IFNL1 is associated with multiple biological processes. One association is supported by evidence stating that IFN-lambda1 diminished the change in ce... | |
medium_divergent_branch_05030 | EHD1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'When immobilized GST-EHD1 was used to fish out interacting proteins from total brain extracts, syndapin II was identified as a major interacting partner.' Which protein, encoded by the gene that interacts with EHD1 in thi... | Protein kinase C and casein kinase substrate in neurons protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05030","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EHD1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'When immobilized GST-EHD1 was used to fish out int... | |
medium_divergent_branch_05031 | DSTN interacts with multiple genes. One of these interactions is supported by evidence stating: 'It binds to G-actin at pH 8 with a 1:1 stoichiometry and Kd approximately 0.2 microM, thereby sequestering monomers and preventing polymerization.' Which protein is encoded by the gene that interacts with DSTN in this speci... | Actin, alpha skeletal muscle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05031","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DSTN interacts with multiple genes. One of these interactions is supported by evidence stating: 'It binds to G-actin at pH 8 with a 1:1 stoichiometry... | |
medium_divergent_branch_05033 | E2F2 interacts with multiple proteins. One specific interaction is characterized by the observation that bufalin markedly promotes the formation of a complex between E2F2 and this partner, leading to the polyubiquitination of E2F2 via K48-linked ubiquitin chains for degradation. Which protein, encoded by the gene inter... | E3 ubiquitin-protein ligase ZFP91 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05033","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"E2F2 interacts with multiple proteins. One specific interaction is characterized by the observation that bufalin markedly promotes the formation of a... | |
medium_divergent_branch_05034 | The gene SLC25A4 is reported to interact with multiple proteins. One specific interaction is supported by evidence stating that the interacting protein and ANT coimmunoprecipitated and interacted in the yeast two-hybrid system. Which protein is encoded by the gene corresponding to this interacting partner? | Apoptosis regulator BAX | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05034","source_qa_id":"medium_divergent_branch_02867","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene SLC25A4 is reported to interact with multiple proteins. One specific interaction is supp... | |
medium_divergent_branch_05035 | NCK2 interacts with multiple genes. One interaction is supported by the statement: 'We report here that Nck-2 interacts with focal adhesion kinase, a cytoplasmic protein tyrosine kinase critically involved in the cellular control of motility.' Which disease is causally linked to the gene identified in this statement? | brain neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05035","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NCK2 interacts with multiple genes. One interaction is supported by the statement: 'We report here that Nck-2 interacts with focal adhesion kinase, a... | |
medium_divergent_branch_05036 | EIF1AX is associated with multiple biological processes. One association is supported by evidence stating that the proteins remodel the initiation complex to orient the initiator aminoacyl-tRNA in a conformation compatible with ribosomal subunit joining. Which broader biological process is the parent of the specific pr... | membraneless organelle assembly | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05036","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EIF1AX is associated with multiple biological processes. One association is supported by evidence stating that the proteins remodel the initiation co... | |
medium_divergent_branch_05037 | The gene KISS1R is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'High potency agonism, indicative of a cognate ligand, was evident from peptides derived from the gene KiSS-1, the expression of which prevents metastasis in melanom... | G protein-coupled peptide receptor activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05037","source_qa_id":"medium_divergent_branch_05001","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene KISS1R is associated with multiple molecular functions via the 'enables' relationship. O... | |
medium_divergent_branch_05038 | RPL11 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using a yeast two-hybrid system, we found hBH bound to human homologues of rat ribosomal proteins L11 and L29.' Which protein, connected to RPL11 via this specific interaction evidence, is the gene that encodes the protein referr... | Bleomycin hydrolase | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05038","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RPL11 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using a yeast two-hybrid system, we found hBH bound to hum... | |
medium_divergent_branch_05039 | TMIGD1 is associated with multiple biological processes. One association is supported by evidence stating that TMIGD1 inhibits tumor cell proliferation and cell migration, arrests the cell cycle at the G2/M phase, and induces the expression of p21CIP1 and p27KIP1, which are key cell cycle inhibitor proteins. Which biol... | epithelial cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05039","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TMIGD1 is associated with multiple biological processes. One association is supported by evidence stating that TMIGD1 inhibits tumor cell proliferati... | |
medium_divergent_branch_05040 | GNB2 interacts with multiple proteins. One interaction is supported by evidence stating: 'The data show that PhLP1 plays a vital role in the assembly of Ggamma2 with all four Gbeta1-4 subunits and in the assembly of Gbeta2 with all twelve Ggamma subunits, without affecting the specificity of the Gbetagamma interactions... | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05040","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GNB2 interacts with multiple proteins. One interaction is supported by evidence stating: 'The data show that PhLP1 plays a vital role in the assembly... | |
medium_divergent_branch_05041 | HSPA9 interacts with multiple genes. One of these interaction partners requires its ZBS domain to form a stable complex with the HSPA9 ATPase domain, and ATP hydrolysis measurements indicate that this ZBS is critical for the full stimulation of HSPA9's catalytic activity. Which molecular function is enabled by this spe... | protein folding chaperone | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05041","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HSPA9 interacts with multiple genes. One of these interaction partners requires its ZBS domain to form a stable complex with the HSPA9 ATPase domain,... | |
medium_divergent_branch_05042 | FOXC1 interacts with multiple proteins. One of these interaction partners has been shown to inhibit proliferation, promote apoptosis, and inhibit migration and invasion of colorectal cancer (CRC) cells. This effect is achieved by interacting with and degrading NOTCH1, TRIM24, and FOXC1 via ubiquitination and proteasoma... | E3 ubiquitin-protein ligase RNF180 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05042","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FOXC1 interacts with multiple proteins. One of these interaction partners has been shown to inhibit proliferation, promote apoptosis, and inhibit mig... | |
medium_divergent_branch_05043 | BRD7 interacts with multiple genes. One of these interaction partners is supported by evidence showing that Celtix-1 directly interacts with IRF-2 based on binding studies with glutathione S-transferase (GST)/IRF-2 fusion proteins, and immunofluorescence studies suggest that Celtix-1 and IRF-2 associate in situ. Which ... | Interferon regulatory factor 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05043","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BRD7 interacts with multiple genes. One of these interaction partners is supported by evidence showing that Celtix-1 directly interacts with IRF-2 ba... | |
medium_divergent_branch_05044 | SLITRK2 is associated with multiple cellular components via the 'located in' relationship. One of these associations is supported by evidence stating that Slitrk proteins are enriched in postsynaptic densities in rat brains. Which biological process is linked to this specific cellular component through the 'capable of'... | synaptic transmission, glutamatergic | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05044","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SLITRK2 is associated with multiple cellular components via the 'located in' relationship. One of these associations is supported by evidence stating... | |
medium_divergent_branch_05045 | MARCH6 interacts with multiple genes. One interaction is supported by evidence showing that in HEK-293 cells, TEB4 and D2 can be coimmunoprecipitated, and increased TEB4 expression reduces D2 activity by approximately 50%. Which disease is associated with the gene identified by this evidence through genomic alterations... | Graves disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05045","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MARCH6 interacts with multiple genes. One interaction is supported by evidence showing that in HEK-293 cells, TEB4 and D2 can be coimmunoprecipitated... | |
medium_divergent_branch_05046 | TRPC6 is associated with multiple cellular components via 'located in' relationships. One specific association is supported by evidence stating: 'However, cell-surface expression of the mutant channel was not increased.' Which cellular component is connected to this specific component through a 'part of' relationship? | cell periphery | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05046","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRPC6 is associated with multiple cellular components via 'located in' relationships. One specific association is supported by evidence stating: 'How... | |
medium_divergent_branch_05047 | HBEGF interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study we have identified the prosurvival cochaperone, BAG-1, as a protein that interacts with the cytoplasmic tail domain of proHB-EGF.' Which protein is encoded by the gene corresponding to this interacting partner? | BAG family molecular chaperone regulator 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05047","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HBEGF interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study we have identified the prosurvival cochapero... | |
medium_divergent_branch_05048 | DVL1 interacts with multiple genes. One specific interaction partner is described as a substrate for the activated EGF receptor (EGFR) that was found to specifically interact with DVL1 during screening. Which disease is associated with this specific interaction partner? | autosomal recessive nonsyndromic hearing loss 102 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05048","source_qa_id":"medium_divergent_branch_00148","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"DVL1 interacts with multiple genes. One specific interaction partner is described as a substrate ... | |
medium_divergent_branch_05049 | WNK3 is associated with multiple biological processes. One association is supported by evidence showing that coexpression of WNK3 leads to an 82.7 +/- 7.1% increase in TRPV5-mediated Ca2+ uptake. Which biological process, connected to the process supported by this evidence via a 'regulates' relationship, is the target ... | calcium ion import | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05049","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WNK3 is associated with multiple biological processes. One association is supported by evidence showing that coexpression of WNK3 leads to an 82.7 +/... | |
medium_divergent_branch_05050 | The biological process of extracellular matrix constituent secretion is enabled by multiple cell types. One such cell type is a fibroblast located in the lamina propria of the intestinal mucosa. This cell expresses PDGFRα and CD81, is negative for α-smooth muscle actin (α-SMA), and is predominantly found in the small i... | gastrointestinal system lamina propria | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05050","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The biological process of extracellular matrix constituent secretion is enabled by multiple cell types. One such cell type is a fibroblast located in... | |
medium_divergent_branch_05051 | FBXO10 interacts with multiple proteins. One of these interacting partners is described as a cytosolic factor that, along with HSP90, orchestrates the specific outer mitochondrial membrane (OMM) targeting of prenylated FBXO10. This partner is identified as the cytosolic factor-like δ subunit of type 6 phosphodiesterase... | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05051","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBXO10 interacts with multiple proteins. One of these interacting partners is described as a cytosolic factor that, along with HSP90, orchestrates th... | |
medium_divergent_branch_05052 | GABBR1 is reported to interact with multiple proteins. One specific interaction is supported by evidence stating: 'By using a yeast two-hybrid approach, we have identified direct interactions between the C-terminal tails of GABA(B)-R1 and GABA(B)-R2 with two related transcription factors, CREB2 and ATFx.' Which protein... | Cyclic AMP-dependent transcription factor ATF-4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05052","source_qa_id":"medium_divergent_branch_04985","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"GABBR1 is reported to interact with multiple proteins. One specific interaction is supported by e... | |
medium_divergent_branch_05055 | RALBP1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Specifically, we found that the endocytic adaptor epsin binds and regulates the biological properties of the signaling molecule RalBP1 (Ral-binding protein 1).' Which disease is associated with the gene identified in this ... | colon carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05055","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RALBP1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Specifically, we found that the endocytic adaptor e... | |
medium_divergent_branch_05056 | LSM11 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we provide evidence that Lsm10 and Lsm11, which replace the Sm proteins D1 and D2 in the histone RNA processing U7 snRNPs, associate with pICln in vitro and in vivo without receiving sDMA modifications.' Which protein is en... | Methylosome protein WDR77 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05056","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LSM11 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we provide evidence that Lsm10 and Lsm11, which repl... | |
medium_divergent_branch_05057 | The entity 'kidney cortex artery cell' is a subclass of two distinct parent cell types. One of these parent types is defined by the logical axiom: 'Any [parent type] that is part of some renal cortex artery.' Which parent cell type satisfies this definition? | kidney blood vessel cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05057","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The entity 'kidney cortex artery cell' is a subclass of two distinct parent cell types. One of these parent types is defined by the logical axiom: 'A... | |
medium_divergent_branch_05058 | TSC22D3 (also known as GILZ) interacts with multiple genes. One specific interaction is characterized by the mechanism where GILZ inhibits the nuclear translocation and DNA binding of a specific transcription factor complex through a direct protein-to-protein interaction with its subunits. Which disease is genetically ... | alveolar rhabdomyosarcoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05058","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TSC22D3 (also known as GILZ) interacts with multiple genes. One specific interaction is characterized by the mechanism where GILZ inhibits the nuclea... | |
medium_divergent_branch_05059 | The gene GRIN1 interacts with multiple partners. One specific interaction is supported by evidence stating: 'Immunoprecipitation experiments with an anti-NR1 antibody demonstrated that the majority of NR3A is associated with NR1 in postnatal day 10 rat cortex (80 +/- 8%), decreasing by half (38 +/- 4%) in the adult rat... | Glutamate receptor ionotropic, NMDA 3A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05059","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene GRIN1 interacts with multiple partners. One specific interaction is supported by evidence stating: 'Immunoprecipitation experiments with an ... | |
medium_divergent_branch_05060 | The gene NLK interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we found that TAB2 could directly interact with this protein and function as a scaffold protein to facilitate the interaction between the kinase encoded by MAP3K7 and this protein.' Which protein is encoded by the ge... | Mitogen-activated protein kinase kinase kinase 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05060","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene NLK interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we found that TAB2 could directly interact wi... | |
medium_divergent_branch_05061 | KRT17 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'More importantly, we uncovered that K17 was a direct interactor of this protein, and K17 ubiquitination could promote its activation in pso-mix-treated HaCaT cells.' What is the name of the protein encoded by the gene co... | Signal transducer and activator of transcription 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05061","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KRT17 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'More importantly, we uncovered that K17 was a dir... | |
medium_divergent_branch_05062 | The gene ATN1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Using the yeast two-hybrid system, we identified a component of nuclear receptor corepressor complexes, as an atrophin-1-interacting protein.' Which protein is encoded by the gene that corresponds to this specifi... | Protein CBFA2T1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05062","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ATN1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Using the yeast two-hybrid system, we ide... | |
medium_divergent_branch_05063 | ATP6AP2 interacts with multiple genes. One of these interacting partners has been shown to directly interact with ATP6AP2 when co-expressed in beta cells, as assessed by co-immunoprecipitation. Which disease is associated with this specific interacting gene through genomic alterations? | hyperinsulinemic hypoglycemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05063","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATP6AP2 interacts with multiple genes. One of these interacting partners has been shown to directly interact with ATP6AP2 when co-expressed in beta c... | |
medium_divergent_branch_05065 | TRRAP interacts with multiple proteins. One of these interaction partners is known to interact with and stabilize all six members of the PIKK family of proteins (mTOR, ATM, ATR, DNA-PKcs, SMG-1, and TRRAP). Which protein is this interaction partner? | TELO2-interacting protein 1 homolog | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05065","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRRAP interacts with multiple proteins. One of these interaction partners is known to interact with and stabilize all six members of the PIKK family ... | |
medium_divergent_branch_05066 | Tumor necrosis factor (TNF) is known to bind to multiple receptor genes. One specific interaction is characterized by the following evidence: 'By measuring the binding of a panel of mTNF/hTNF chimeras to both mTNF-R, we pinpointed the TNF region that mediates the interaction with mTNF-RII.' Based on this description, w... | TRADD | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05066","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Tumor necrosis factor (TNF) is known to bind to multiple receptor genes. One specific interaction is characterized by the following evidence: 'By mea... | |
medium_divergent_branch_05068 | EIF2B5 is associated with multiple biological processes. One association is supported by evidence that RNAi targeting of EIF2B5 severely compromised the induction of GFAP+ cells from normal human glial progenitors. Which biological process, connected to the process implicated by this evidence via a 'part of' relationsh... | astrocyte differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05068","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EIF2B5 is associated with multiple biological processes. One association is supported by evidence that RNAi targeting of EIF2B5 severely compromised ... | |
medium_divergent_branch_05069 | The metacarpal bone is classified as a type of anatomy via the 'is a' relationship. One such classification is supported by the description: 'A bone that is part of the metacarpal skeleton.' Which anatomical structure is the parent of this specific classification in the 'part of' hierarchy? | skeleton of manual digitopodium | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05069","source_qa_id":"medium_divergent_branch_01725","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The metacarpal bone is classified as a type of anatomy via the 'is a' relationship. One such clas... | |
medium_divergent_branch_05071 | CCR6 is associated with multiple biological processes. One association is supported by evidence that capacitated human sperm exhibit directional movement towards CCL20 and display modifications in motility parameters. Which biological process is connected to this specific CCR6-associated process through a 'part of' rel... | sperm capacitation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05071","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CCR6 is associated with multiple biological processes. One association is supported by evidence that capacitated human sperm exhibit directional move... | |
medium_divergent_branch_05072 | TPD52 interacts with multiple proteins. One interaction is supported by evidence stating: 'Analyses of yeast strains co-transfected with paired D52-like constructs indicated that D52-like fusion proteins interact in homo- and heteromeric fashions through their predicted coiled-coil domains.' Which protein, encoded by t... | Tumor protein D53 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05072","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TPD52 interacts with multiple proteins. One interaction is supported by evidence stating: 'Analyses of yeast strains co-transfected with paired D52-l... | |
medium_divergent_branch_05073 | The protein YBX1 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating: 'Both these proteins are found in exosomes secreted by HEK293 cells.' Identify the broader cellular component category that is connected to this specific locatio... | extracellular vesicle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05073","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein YBX1 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence... | |
medium_divergent_branch_05074 | PHIP interacts with multiple proteins. One of these interaction partners is recruited to chromatin by the replication origin binding protein RepID (also known as DCAF14 or PHIP) as part of the CRL4 complex. Which protein, encoded by the gene connected to PHIP via this interaction, is the subject of this recruitment evi... | Cullin-4A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05074","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PHIP interacts with multiple proteins. One of these interaction partners is recruited to chromatin by the replication origin binding protein RepID (a... | |
medium_divergent_branch_05075 | ANXA2 interacts with multiple genes. One interaction is supported by evidence stating: 'Our studies revealed that a member of the STAT family of transcription factors is a binding partner of ANXA2.' Which disease is connected to this interaction partner through a biomarker relationship? | scleroderma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05075","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ANXA2 interacts with multiple genes. One interaction is supported by evidence stating: 'Our studies revealed that a member of the STAT family of tran... | |
medium_divergent_branch_05076 | ACVR2A is involved in multiple biological processes. One such process is supported by evidence stating: 'Our results indicate that activin signal transduction mediated through its type I and type II receptors results in an increase in the hemoglobin content of the cells and limits their proliferation.' Which biological... | erythrocyte differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05076","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ACVR2A is involved in multiple biological processes. One such process is supported by evidence stating: 'Our results indicate that activin signal tra... | |
medium_divergent_branch_05078 | GLMN interacts with multiple proteins. Evidence for one of these interactions notes that 'the closely related FKBP12.6 and a related peptidyl-prolyl cis-trans isomerase emerged as novel binding partners.' Which protein is encoded by the gene connected to GLMN through this specific interaction? | Peptidyl-prolyl cis-trans isomerase FKBP5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05078","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GLMN interacts with multiple proteins. Evidence for one of these interactions notes that 'the closely related FKBP12.6 and a related peptidyl-prolyl ... | |
medium_divergent_branch_05079 | WT1 interacts with multiple genes. One of these interaction partners is specifically reported to interact with WT1 both in vitro and in vivo. Which gene is this? | CHD1L | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05079","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WT1 interacts with multiple genes. One of these interaction partners is specifically reported to interact with WT1 both in vitro and in vivo. Which g... | |
medium_divergent_branch_05080 | GPR15LG is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence describing the purification of an agonistic ligand for GPR15 from porcine colonic tissue and its functional characterization, noting that in humans this ligand (GPR15L) is encoded by... | signaling receptor binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05080","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GPR15LG is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence describing ... | |
medium_divergent_branch_05081 | TWIST1 interacts with multiple proteins. One of these interaction partners is reported to directly interact with TWIST1 and specifically cleave the K48-linked polyubiquitin chains of TWIST1 induced by FBXL14. Which cell type is enriched in the gene encoding this specific interaction partner? | mucosal-associated invariant T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05081","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TWIST1 interacts with multiple proteins. One of these interaction partners is reported to directly interact with TWIST1 and specifically cleave the K... | |
medium_divergent_branch_05082 | KCNIP3 interacts with multiple genes. One of these interaction partners is described in evidence stating that Calsenilin interacts with both PS1 and a second presenilin gene in cultured cells and can regulate the levels of a proteolytic product of this second presenilin gene. Which disease is connected to this specific... | dementia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05082","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KCNIP3 interacts with multiple genes. One of these interaction partners is described in evidence stating that Calsenilin interacts with both PS1 and ... | |
medium_divergent_branch_05083 | UNC13B interacts with multiple genes. One interaction is supported by evidence stating: 'In the present study, we demonstrate by three independent methods that the C terminus of Munc13-1 interacts directly with a putative coiled coil domain in the N-terminal part of syntaxin.' Which biological process is the gene ident... | neurotransmitter secretion | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05083","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UNC13B interacts with multiple genes. One interaction is supported by evidence stating: 'In the present study, we demonstrate by three independent me... | |
medium_divergent_branch_05084 | LEF1 interacts with multiple genes. One specific interaction involves the basic helix-loop-helix and leucine-zipper region of a transcription factor binding to LEF-1. Which disease is causally linked to this interacting partner? | megacolon | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05084","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LEF1 interacts with multiple genes. One specific interaction involves the basic helix-loop-helix and leucine-zipper region of a transcription factor ... | |
medium_divergent_branch_05085 | MIR34A is associated with multiple biological processes. One association is supported by evidence stating: 'These data suggested a unique mechanism that shear stress induces the expression of miR-34a, which targets to Foxj2 and promotes endothelial differentiation of EPCs.' Identify the biological process that is posit... | blood vessel endothelial cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05085","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR34A is associated with multiple biological processes. One association is supported by evidence stating: 'These data suggested a unique mechanism t... | |
medium_divergent_branch_05086 | HDAC3 interacts with multiple proteins. One interaction is described by the statement: 'Here, we show that the catalytic domain of HDAC4 interacts with HDAC3 via the transcriptional corepressor N-CoR/[REDACTED].' Which protein, connected to HDAC3 through this specific interaction context, is encoded by the gene in ques... | Nuclear receptor corepressor 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05086","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HDAC3 interacts with multiple proteins. One interaction is described by the statement: 'Here, we show that the catalytic domain of HDAC4 interacts wi... | |
medium_divergent_branch_05087 | UBE2D2 interacts with multiple genes. One of these interaction partners was identified as an E3 ligase that interacts with the E2 enzyme UBE2D2. Which cellular component is this specific interacting gene located in? | endoplasmic reticulum membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05087","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBE2D2 interacts with multiple genes. One of these interaction partners was identified as an E3 ligase that interacts with the E2 enzyme UBE2D2. Whic... | |
medium_divergent_branch_05088 | NCF1 interacts with multiple genes. One of these interaction partners is described in the following evidence: 'We demonstrate that TNF-associated factor (TRAF) 4 associates with p47(phox), a component of cytosolic NADPH oxidase, and physically interacts and functionally counteracts with TRAF6 and Toll-IL-1 receptor (TI... | male breast carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05088","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NCF1 interacts with multiple genes. One of these interaction partners is described in the following evidence: 'We demonstrate that TNF-associated fac... |
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