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medium_divergent_branch_05089 | The conjunctiva is anatomically adjacent to multiple structures. One of these structures is described by the evidence: 'The mucous membrane that lines the inner surface of the eyelids and the front of the eyeball.' Which of the adjacent structures is a part of the tunica fibrosa of the eyeball? | tunica fibrosa of eyeball | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05089","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The conjunctiva is anatomically adjacent to multiple structures. One of these structures is described by the evidence: 'The mucous membrane that line... | |
medium_divergent_branch_05090 | The MAF gene interacts with multiple proteins. One specific interaction is characterized by the finding that the interacting partner prevents c-Maf degradation by decreasing its polyubiquitination level. Which protein corresponds to this specific interaction partner? | Ubiquitin carboxyl-terminal hydrolase 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05090","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The MAF gene interacts with multiple proteins. One specific interaction is characterized by the finding that the interacting partner prevents c-Maf d... | |
medium_divergent_branch_05091 | DAB2 interacts with multiple proteins. One specific interaction is characterized by the fact that the μ-homology domain (μHD) of the interacting partner binds directly to DPF sequences in DAB2, sequences that are also known to bind AP2. Which protein corresponds to this specific interaction partner? | F-BAR domain only protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05091","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DAB2 interacts with multiple proteins. One specific interaction is characterized by the fact that the μ-homology domain (μHD) of the interacting part... | |
medium_divergent_branch_05092 | EPC1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Finally, analogous to yeast, a recombinant trimeric complex formed by Tip60, EPC1, and this interaction partner is sufficient to reconstitute robust nucleosomal HAT activity in vitro.' Which protein, encoded by the gene correspond... | Inhibitor of growth protein 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05092","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EPC1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Finally, analogous to yeast, a recombinant trimeric complex... | |
medium_divergent_branch_05093 | IGFBP3 interacts with multiple proteins. One of these interacting partners exhibits negligible affinity for the other five IGFBPs, and its iron-saturated holo-form binds IGFBP-3 more avidly than its unsaturated form. Which protein is encoded by the gene corresponding to this specific interacting partner? | Serotransferrin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05093","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IGFBP3 interacts with multiple proteins. One of these interacting partners exhibits negligible affinity for the other five IGFBPs, and its iron-satur... | |
medium_divergent_branch_05094 | ABL2 interacts with multiple proteins. One of these interaction partners binds to the ABL SH3 and SH2 domains, and this binding stimulates the catalytic activity of ABL2. Which protein is this interaction partner? | Ras and Rab interactor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05094","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ABL2 interacts with multiple proteins. One of these interaction partners binds to the ABL SH3 and SH2 domains, and this binding stimulates the cataly... | |
medium_divergent_branch_05095 | The biological process 'regulation of sphingolipid biosynthetic process' is defined as any process that modulates the rate, frequency, or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis involves the chemical reactions and pathways resulting in the formation of sphingolipids, a class of lipids containing ... | lipid biosynthetic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05095","source_qa_id":"medium_divergent_branch_03430","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'regulation of sphingolipid biosynthetic process' is defined as any proces... | |
medium_divergent_branch_05096 | NCOA3 (SRC-3) interacts with multiple proteins. One specific interaction is characterized by direct binding in an ERalpha-independent manner, which subsequently promotes E2-dependent SRC-3 binding to ERalpha (measured by co-IP) and SRC-3 recruitment to the cyclin D1 gene (measured by chromatin IP assays). Which protein... | Nuclear receptor corepressor 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05096","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NCOA3 (SRC-3) interacts with multiple proteins. One specific interaction is characterized by direct binding in an ERalpha-independent manner, which s... | |
medium_divergent_branch_05097 | AKT1 interacts with multiple genes. One specific interaction is characterized by the finding that a pseudokinase disrupts insulin signaling by binding directly to Akt and blocking its activation. Which disease is associated with this specific interacting gene? | thymoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05097","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AKT1 interacts with multiple genes. One specific interaction is characterized by the finding that a pseudokinase disrupts insulin signaling by bindin... | |
medium_divergent_branch_05098 | SIRT4 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating that SIRT4 is a matrix protein that undergoes cleavage at amino acid 28 following its import into mitochondria. Which cellular component is the parent structure (linked by '... | mitochondrion | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05098","source_qa_id":"medium_divergent_branch_03441","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"SIRT4 is associated with multiple cellular components via the 'located in' relationship. One spec... | |
medium_divergent_branch_05099 | BRAP interacts with multiple proteins. One specific interaction involves BRCA1-associated protein 2 binding to a partner that inhibits the ERK signal transduction cascade. Which protein is encoded by the gene corresponding to this interacting partner? | Kinase suppressor of Ras 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05099","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BRAP interacts with multiple proteins. One specific interaction involves BRCA1-associated protein 2 binding to a partner that inhibits the ERK signal... | |
medium_divergent_branch_05100 | PFN1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In fact, the mutant actin bound to profilin less efficiently than normal actin did.' Which protein product is encoded by the gene corresponding to this specific interaction partner? | Actin, cytoplasmic 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05100","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PFN1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In fact, the mutant actin bound to profilin less efficientl... | |
medium_divergent_branch_05101 | FURIN interacts with multiple genes. One of these interaction partners is known to direct the trans-Golgi network (TGN) localization of FURIN by binding to the protease's phosphorylated cytosolic domain. Which biological process is this specific interaction partner involved in? | protein localization to plasma membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05101","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FURIN interacts with multiple genes. One of these interaction partners is known to direct the trans-Golgi network (TGN) localization of FURIN by bind... | |
medium_divergent_branch_05102 | The RB1 gene interacts with multiple partners. One specific interaction is supported by evidence that pRb interacts directly with the acetyltransferase domain of a histone acetyltransferase in vitro and can associate with this enzyme in differentiated cells. Which disease is connected to this specific interacting partn... | glioblastoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05102","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The RB1 gene interacts with multiple partners. One specific interaction is supported by evidence that pRb interacts directly with the acetyltransfera... | |
medium_divergent_branch_05103 | SSX2IP interacts with multiple genes. One of these interaction partners is an F-actin-bundling protein that binds ADIP and is indirectly associated with E-cadherin through its direct binding to alpha-catenin. Which disease is connected to this specific interaction partner through genomic alterations? | autosomal dominant macrothrombocytopenia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05103","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SSX2IP interacts with multiple genes. One of these interaction partners is an F-actin-bundling protein that binds ADIP and is indirectly associated w... | |
medium_divergent_branch_05105 | Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.776 and an adjusted p-value of 0.0422. Which disease is associated with that selected gene? | preeclampsia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05105","source_qa_id":"medium_divergent_branch_02682","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showe... | |
medium_divergent_branch_05106 | The gene EIF3I interacts with multiple partners. One specific interaction is supported by evidence stating: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 impairs translation in vivo.' Identify the cellular component where the gene corresponding to this specific interaction is located. | eukaryotic translation initiation factor 3 complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05106","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene EIF3I interacts with multiple partners. One specific interaction is supported by evidence stating: 'Indeed, CIF-1 binds eIF-3.F and inactiva... | |
medium_divergent_branch_05107 | Primate erythroparvovirus 1 upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.133 and an adjusted p-value of 0.0381. Which disease has a causal relation with that selected gene? | gastric carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05107","source_qa_id":"medium_divergent_branch_02696","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Primate erythroparvovirus 1 upregulates several genes. In the recorded experiment, one branch ... | |
medium_divergent_branch_05108 | FBXW7 is associated with multiple biological processes. One association is supported by evidence stating that FBXW7, a member of the F-box family of proteins and substrate-targeting subunit of the SKP1-CUL1-F-Box E3 ubiquitin ligase complex, promotes mitotic cell death and prevents mitotic slippage. Which biological pr... | regulation of cell cycle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05108","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBXW7 is associated with multiple biological processes. One association is supported by evidence stating that FBXW7, a member of the F-box family of ... | |
medium_divergent_branch_05109 | CSNK1G2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using a yeast two-hybrid screening to clone the interacting proteins of a specific metastasis-associated protein, we identified casein kinase I-gamma 2 (CKI-gamma2, a ubiquitously expressed cytoplasmic kinase) as a binding part... | Metastasis-associated protein MTA1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05109","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CSNK1G2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using a yeast two-hybrid screening to clone the interact... | |
medium_divergent_branch_05110 | FOXO3 is associated with multiple biological processes. One specific association is supported by evidence stating that AMBRA1 promotes the stability of the transcriptional activator FOXO3, which subsequently triggers FOXP3 transcription. Which biological process is positively regulated by the process linked to FOXO3 vi... | regulatory T cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05110","source_qa_id":"medium_divergent_branch_07075","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"FOXO3 is associated with multiple biological processes. One specific association is supported by ... | |
medium_divergent_branch_05111 | The gene HIST1H1B is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 11.65 TPM, a z-score of 2.11, and a fold enrichment of 5.06. Which cell type corresponds to this specific expression profile, and what is its immediate parent category in the cell type hierarc... | dendritic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05111","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene HIST1H1B is enriched in multiple cell types. One specific connection is supported by expression data showing a mean of 11.65 TPM, a z-score ... | |
medium_divergent_branch_05112 | BRCA1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'Here, we review recent advancements in structural and cellular biology that have provided critical insights into how the BRCA1/BARD1 complex serves as both a nucleosome reader and writer to facilitate tra... | chromatin organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05112","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BRCA1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'Here, we review recent advancemen... | |
medium_divergent_branch_05113 | PKN1 interacts with multiple genes. One of these interactions is supported by evidence stating that 'Co-immunoprecipitation and in vitro pull-down assays independently confirmed the interaction between the two proteins.' Which gene is connected to PKN1 through this specific interaction? | MED26 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05113","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PKN1 interacts with multiple genes. One of these interactions is supported by evidence stating that 'Co-immunoprecipitation and in vitro pull-down as... | |
medium_divergent_branch_05114 | WDR83 interacts with multiple proteins. One of these interaction partners is involved in a complex where Morg1 interacts with the apical transmembrane protein Crumbs3 to promote Par6-aPKC binding to Crumbs3, a process reinforced by the apically localized small GTPase Cdc42. Which protein is encoded by the gene correspo... | Protein crumbs homolog 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05114","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WDR83 interacts with multiple proteins. One of these interaction partners is involved in a complex where Morg1 interacts with the apical transmembran... | |
medium_divergent_branch_05115 | ERCC4 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Co-immunoprecipitation studies show that alphaSpIISigma*, FANCA and XPF co-immunoprecipitate with each other from normal human nuclear proteins.' Identify the gene from this specific interaction context and determine which ... | immunoglobulin A vasculitis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05115","source_qa_id":"medium_divergent_branch_00563","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ERCC4 interacts with multiple genes. One specific interaction is supported by evidence stating: '... | |
medium_divergent_branch_05116 | CALM2 interacts with multiple genes. One specific interaction is supported by evidence showing that calmodulin binds directly to a specific interacting gene in a calcium-dependent manner both in vitro and in vivo. Which disease is associated with this specific interacting gene through genomic alterations? | nodular fasciitis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05116","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CALM2 interacts with multiple genes. One specific interaction is supported by evidence showing that calmodulin binds directly to a specific interacti... | |
medium_divergent_branch_05117 | SSTR2 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by the following evidence: 'Recently, the human genes encoding five subtypes of somatostatin receptor (SSTR1-SSTR5) were cloned.' Identify the parent molecular function that is linked to this spec... | neuropeptide receptor activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05117","source_qa_id":"medium_divergent_branch_01821","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"SSTR2 is associated with multiple molecular functions via the 'enables' relationship. One specifi... | |
medium_divergent_branch_05118 | MAP3K5 interacts with multiple genes. One of these interaction partners is a deubiquitinating enzyme identified as a binding partner of ASK1 that mediates oxidative stress-induced cell death through activation of the JNK and p38 MAPK pathways. Which disease is connected to this specific interacting gene through a bioma... | multiple evanescent white dot syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05118","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP3K5 interacts with multiple genes. One of these interaction partners is a deubiquitinating enzyme identified as a binding partner of ASK1 that med... | |
medium_divergent_branch_05119 | SHANK3 interacts with multiple genes. One specific interaction is characterized by mediation through the PDZ domain of Shank and the C-terminal leucine zipper domain and the PDZ domain-binding motif at the extreme C terminus of a guanine nucleotide exchange factor. Which disease is associated with the gene involved in ... | secondary polycythemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05119","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SHANK3 interacts with multiple genes. One specific interaction is characterized by mediation through the PDZ domain of Shank and the C-terminal leuci... | |
medium_divergent_branch_05120 | CUL3 interacts with multiple proteins. One interaction is described by the statement: 'In this report, we demonstrate that the protein binds to the ubiquitin ligase scaffold, CUL3, via its first BTB domain and show in vitro and in vivo that the protein is a substrate for a CUL3-based ubiquitin ligase complex.' Which pr... | Rho-related BTB domain-containing protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05120","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CUL3 interacts with multiple proteins. One interaction is described by the statement: 'In this report, we demonstrate that the protein binds to the u... | |
medium_divergent_branch_05121 | ZBTB33 interacts with multiple proteins. One interaction is supported by evidence stating: 'The T606-phosphorylated Kaiso (pT606-Kaiso) could directly bind to 14-3-3 family proteins, and depletion of T606 phosphorylation by T606A mutation abolished most of the Kaiso-14-3-3 binding.' Which protein, encoded by the gene i... | 14-3-3 protein sigma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05121","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZBTB33 interacts with multiple proteins. One interaction is supported by evidence stating: 'The T606-phosphorylated Kaiso (pT606-Kaiso) could directl... | |
medium_divergent_branch_05122 | DHX15 interacts with multiple genes. One of these interacting partners has been shown to interact with human PRP43 in HeLa cells. Which disease is associated with this specific interacting partner? | hepatoblastoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05122","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DHX15 interacts with multiple genes. One of these interacting partners has been shown to interact with human PRP43 in HeLa cells. Which disease is as... | |
medium_divergent_branch_05123 | CASP10 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Fluorescent resonance energy transfer analysis indicates that the death-effector domains of caspase-8 and -10 both interact with the death-effector domain of this protein.' Which protein is encoded by the gene correspon... | FAS-associated death domain protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05123","source_qa_id":"medium_divergent_branch_04158","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"CASP10 interacts with multiple proteins. One specific interaction is supported by evidence statin... | |
medium_divergent_branch_05124 | TDRD3 interacts with multiple genes. One interaction is supported by evidence stating: 'The epigenetic 'reader' Tudor domain-containing protein 3 (TDRD3), which recognizes methylarginine marks on histones and on the C-terminal domain of RNA polymerase II, was previously shown to recruit DNA topoisomerase 3B to relax ne... | DNA topoisomerase 3-beta-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05124","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TDRD3 interacts with multiple genes. One interaction is supported by evidence stating: 'The epigenetic 'reader' Tudor domain-containing protein 3 (TD... | |
medium_divergent_branch_05125 | Cone photoreceptor cells are anatomically part of two distinct structures. One of these structures is defined as the specific layer within the retina where the photoreceptor cell receptor segments reside. Which broader anatomical category is this specific retinal layer a type of? | layer of retina | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05125","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Cone photoreceptor cells are anatomically part of two distinct structures. One of these structures is defined as the specific layer within the retina... | |
medium_divergent_branch_05126 | RCAN3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we report the interaction between DSCR1L2 and the human cardiac troponin I, the heart-specific inhibitory subunit of the troponin complex, a central component of the contractile apparatus.' Which protein, connected to RCAN3... | Troponin I, cardiac muscle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05126","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RCAN3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we report the interaction between DSCR1L2 and the hu... | |
medium_divergent_branch_05127 | The cardiac muscle tissue of the trabeculae carneae of the right ventricle is a subtype of two distinct anatomical entities. One of these entities is defined as a portion of the trabeculae carneae cardiac muscle tissue that is part of the right ventricle. Which of these two entities is connected to the starting tissue ... | trabecula carnea | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05127","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The cardiac muscle tissue of the trabeculae carneae of the right ventricle is a subtype of two distinct anatomical entities. One of these entities is... | |
medium_divergent_branch_05128 | MARK2 interacts with multiple genes. One of these interaction partners is known to bind PAR1 and enhance its kinase activity. Which cellular component is this specific interaction partner located in? | cell-cell junction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05128","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MARK2 interacts with multiple genes. One of these interaction partners is known to bind PAR1 and enhance its kinase activity. Which cellular componen... | |
medium_divergent_branch_05129 | MEF2D interacts with multiple proteins. One of these interaction partners has been experimentally shown to interact directly with the MADS box domain. Which protein is encoded by the gene corresponding to this specific interaction partner? | Histone deacetylase 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05129","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MEF2D interacts with multiple proteins. One of these interaction partners has been experimentally shown to interact directly with the MADS box domain... | |
medium_divergent_branch_05130 | GRIP1 interacts with multiple genes. One interaction is supported by evidence stating: 'As anticipated from its location, the L454S mutant interacts weakly with CoAs, such as SRC1 and glucocorticoid receptor interacting protein 1 (GRIP1) in gel mobility shift assays and in mammalian two-hybrid assays, even in the prese... | congenital nongoitrous hypothyroidism 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05130","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GRIP1 interacts with multiple genes. One interaction is supported by evidence stating: 'As anticipated from its location, the L454S mutant interacts ... | |
medium_divergent_branch_05131 | The gene TOPORS interacts with multiple other genes. One of these interacting partners is described by evidence stating: 'When expressed in HeLa cells as a green fluorescent protein fusion, the protein localizes in the nucleus in a punctate pattern and co-immunoprecipitates with topoisomerase I.' Which protein is encod... | DNA topoisomerase 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05131","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TOPORS interacts with multiple other genes. One of these interacting partners is described by evidence stating: 'When expressed in HeLa cell... | |
medium_divergent_branch_05132 | MIR338 is associated with multiple biological processes. One association is supported by evidence stating: 'We show that miR-338-5p can bind to the interleukin 6 (IL-6) 3' untranslated region and can regulate IL-6 mRNA and protein levels in vitro.' Which biological process, connected to the process supported by this ev... | interleukin-6 production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05132","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR338 is associated with multiple biological processes. One association is supported by evidence stating: 'We show that miR-338-5p can bind to the i... | |
medium_divergent_branch_05134 | JMJD8 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating that JMJD8 is exclusively detectable in this compartment, which argues against a role as a histone-modifying enzyme. Which cellular component is connected to this specific c... | cellular anatomical structure | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05134","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"JMJD8 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating th... | |
medium_divergent_branch_05136 | EGLN3 interacts with multiple proteins. One of these interaction partners exhibits enhanced binding to HIF-1α and increased coactivator function upon interaction with prolyl hydroxylase 3 (PHD3). Which protein, encoded by the gene connected to EGLN3 via this specific interaction, is described by this evidence? | Pyruvate kinase PKM | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05136","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EGLN3 interacts with multiple proteins. One of these interaction partners exhibits enhanced binding to HIF-1α and increased coactivator function upon... | |
medium_divergent_branch_05137 | HNRNPUL1 interacts with multiple proteins. One of these interaction partners was identified via yeast two-hybrid screening as a novel chromatin-associated bromodomain-containing protein that binds to E1B-AP5. Which protein is encoded by the gene corresponding to this specific interaction partner? | Bromodomain-containing protein 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05137","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HNRNPUL1 interacts with multiple proteins. One of these interaction partners was identified via yeast two-hybrid screening as a novel chromatin-assoc... | |
medium_divergent_branch_05138 | UHRF1 interacts with multiple proteins. One interaction is supported by proteomic analysis of immunoprecipitates of a specific LIM and SH3 domain-containing protein, which revealed that this protein associates with the epigenetic machinery, including UHRF1, DNMT1, G9a, and the transcription factor Snail1. Which protein... | LIM and SH3 domain protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05138","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UHRF1 interacts with multiple proteins. One interaction is supported by proteomic analysis of immunoprecipitates of a specific LIM and SH3 domain-con... | |
medium_divergent_branch_05139 | FBP1 interacts with multiple proteins. One of these interaction partners was validated using a co-immunoprecipitation assay, specifically involving this partner and either FBP1 or mTOR. What is the name of the protein encoded by this interaction partner? | F-box/WD repeat-containing protein 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05139","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBP1 interacts with multiple proteins. One of these interaction partners was validated using a co-immunoprecipitation assay, specifically involving t... | |
medium_divergent_branch_05140 | MBD3 interacts with multiple proteins. One specific interaction partner is characterized by the following evidence: it interacts with MBD3 both in vitro and in vivo, co-localizes with MBD3 but not with MBD2, and does not localize to methyl-CpG-rich regions in the nucleus. Which protein is encoded by the gene correspond... | Methyl-CpG-binding domain protein 3-like 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05140","source_qa_id":"medium_divergent_branch_02334","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"MBD3 interacts with multiple proteins. One specific interaction partner is characterized by the f... | |
medium_divergent_branch_05141 | APBB1 interacts with multiple genes. One interaction is supported by evidence stating: 'We carried out yeast two-hybrid studies with a PTB domain of FE65, focusing on those genes that might be involved in nuclear signaling, and identified and validated Teashirt proteins as FE65 interacting proteins in neurons.' Which b... | negative regulation of DNA-templated transcription | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05141","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"APBB1 interacts with multiple genes. One interaction is supported by evidence stating: 'We carried out yeast two-hybrid studies with a PTB domain of ... | |
medium_divergent_branch_05142 | ZMYND11 interacts with multiple genes. One interaction is characterized by structural studies showing that H3.3-dependent recognition is mediated by the encapsulation of the H3.3-specific 'Ser 31' residue in a composite pocket formed by the tandem bromo-PWWP domains of ZMYND11. Which disease is connected to this specif... | pediatric mesenchymal chondrosarcoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05142","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZMYND11 interacts with multiple genes. One interaction is characterized by structural studies showing that H3.3-dependent recognition is mediated by ... | |
medium_divergent_branch_05143 | The biological process 'positive regulation of T-helper 1 type immune response' is enabled by multiple cell types. One specific cell type involved is described as a mature NK T cell that secretes interferon-gamma and enhances Th1 immune responses. What is the immediate parent class (is_a relationship) of this specific ... | CD4-negative, CD8-negative type I NK T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05143","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The biological process 'positive regulation of T-helper 1 type immune response' is enabled by multiple cell types. One specific cell type involved is... | |
medium_divergent_branch_05145 | LIMS1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We show that Nck-2 interacts with PINCH, a LIM-only protein implicated in integrin-linked kinase signaling.' Which protein, connected to LIMS1 via this specific interaction evidence, is the gene that encodes the protein named in ... | Cytoplasmic protein NCK2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05145","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LIMS1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We show that Nck-2 interacts with PINCH, a LIM-only protei... | |
medium_divergent_branch_05146 | Garland cells are a specific type of cell found in flies. Evidence describes a large cell that forms a 'garland' around the anterior end of the proventriculus (cardia) at its junction with the esophagus in both adult and larval flies. This cell is surrounded by a basement membrane and features numerous micro-invaginati... | multinucleate cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05146","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Garland cells are a specific type of cell found in flies. Evidence describes a large cell that forms a 'garland' around the anterior end of the prove... | |
medium_divergent_branch_05147 | PFDN6 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We performed a mass spectrometry (MS)-based proteomic analysis to identify nuclear proteins interacting with a specific protein in prostate cells. We identified all the components of the R2TP/prefoldin-like complex as nu... | Unconventional prefoldin RPB5 interactor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05147","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PFDN6 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We performed a mass spectrometry (MS)-based prote... | |
medium_divergent_branch_05148 | JMJD1C interacts with multiple proteins. One specific interaction was identified using a fragment of the human target protein (amino acids 325-919) as bait in a yeast two-hybrid screen, which revealed that a region of the human JMJD1C gene interacts with this target. Which protein is encoded by the gene corresponding t... | Androgen receptor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05148","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"JMJD1C interacts with multiple proteins. One specific interaction was identified using a fragment of the human target protein (amino acids 325-919) a... | |
medium_divergent_branch_05149 | KMT5A (also known as SETD8 or PR-Set7) interacts with multiple proteins. One specific interaction is described by the following evidence: 'Here, we provide evidence to support that SET8 monomethylates Lys(20) of histone H4 during S phase by tethering to [protein encoded by NCBIGene:5111] via a putative [protein encoded... | DNA sliding clamp PCNA | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05149","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KMT5A (also known as SETD8 or PR-Set7) interacts with multiple proteins. One specific interaction is described by the following evidence: 'Here, we p... | |
medium_divergent_branch_05150 | The IL4R gene is associated with multiple binding partners. One specific interaction is supported by evidence stating: 'Using peptides corresponding to the ITIM of hIL-4Ralpha, we demonstrate that tyrosine-phosphorylated peptides, but not their nonphosphorylated counterparts, coprecipitate SH2-containing tyrosine phosp... | Tyrosine-protein phosphatase non-receptor type 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05150","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The IL4R gene is associated with multiple binding partners. One specific interaction is supported by evidence stating: 'Using peptides corresponding ... | |
medium_divergent_branch_05151 | RNF41 interacts with multiple proteins. One of these interaction partners is reported to interact with Nrdp1, Sts1, and Sts2, and evidence links the K33 ubiquitin linkage on this partner to Sts1- and Sts2-mediated dephosphorylation. Which protein is encoded by the gene corresponding to this specific interaction partner... | Tyrosine-protein kinase ZAP-70 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05151","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF41 interacts with multiple proteins. One of these interaction partners is reported to interact with Nrdp1, Sts1, and Sts2, and evidence links the ... | |
medium_divergent_branch_05152 | FANCF is known to bind to multiple partner genes. One specific interaction is supported by evidence stating that MM1 interacts with the Fanconi anemia (FA) core complex by binding to the partner gene in question, whereas MM2 interacts with RM1 and topoisomerase IIIalpha, which are components of the BLM-SLX4 (BS) comple... | TELO2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05152","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FANCF is known to bind to multiple partner genes. One specific interaction is supported by evidence stating that MM1 interacts with the Fanconi anemi... | |
medium_divergent_branch_05154 | The PML protein interacts with multiple partners. One specific interaction is characterized by physical binding both in vitro and in vivo, as well as co-localization within PML nuclear bodies (PML-NBs). Which protein, encoded by the gene connected to PML via this specific interaction, is the subject of this description... | Cellular tumor antigen p53 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05154","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The PML protein interacts with multiple partners. One specific interaction is characterized by physical binding both in vitro and in vivo, as well as... | |
medium_divergent_branch_05155 | ATG7 interacts with multiple proteins. One of these interaction partners is described as being acetylated upon dissociation from sirtuin-2 (SIRT2) in response to stress, after which the acetylated protein binds to ATG7 (an E1-like protein) to influence the autophagic process leading to cell death. Which protein, connec... | Forkhead box protein O1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05155","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATG7 interacts with multiple proteins. One of these interaction partners is described as being acetylated upon dissociation from sirtuin-2 (SIRT2) in... | |
medium_divergent_branch_05156 | The gene ANK2 is associated with multiple biological processes. One association is supported by evidence stating: 'These data identify ANK2 variants as modulators of human arrhythmias, provide the first insight into the clinical spectrum of 'ankyrin-B syndrome,' and reinforce the role of ankyrin-B-dependent protein int... | atrial cardiac muscle cell to AV node cell signaling | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05156","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ANK2 is associated with multiple biological processes. One association is supported by evidence stating: 'These data identify ANK2 variants ... | |
medium_divergent_branch_05157 | E2F4 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we show that the human G1 phase regulator [interaction partner] associates with both activator (E2F1 and E2F3a) and repressor (E2F4) E2F proteins, properties that are conserved in insect cells.' Which protein is encoded by t... | Host cell factor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05157","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"E2F4 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we show that the human G1 phase regulator [interactio... | |
medium_divergent_branch_05159 | PRMT8 interacts with multiple proteins. One interaction is supported by evidence stating: 'Among the extracted proteins were several heterogeneous nuclear ribonucleoproteins (hnRNP), RNA-helicases (DEAD box proteins), the TET-family proteins TLS, Ewing's sarcoma (EWS), and TAF(II)68, and caprin, which all contain RGG m... | TATA-binding protein-associated factor 2N | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05159","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRMT8 interacts with multiple proteins. One interaction is supported by evidence stating: 'Among the extracted proteins were several heterogeneous nu... | |
medium_divergent_branch_05160 | SAP18 interacts with multiple genes. One of these interaction partners is a polypeptide associated with the co-repressor protein Sin3. Which cellular component is this specific interacting gene located in? | epsilon DNA polymerase complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05160","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SAP18 interacts with multiple genes. One of these interaction partners is a polypeptide associated with the co-repressor protein Sin3. Which cellular... | |
medium_divergent_branch_05161 | MIR92A1 is associated with multiple biological processes. One association is supported by evidence that forced overexpression of miR-92a in endothelial cells blocked angiogenesis in vitro and in vivo. Which biological process, connected to the process supported by this evidence, is the target of a 'negatively regulates... | endothelial cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05161","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR92A1 is associated with multiple biological processes. One association is supported by evidence that forced overexpression of miR-92a in endotheli... | |
medium_divergent_branch_05162 | The gene WAS is associated with multiple proteins via binding interactions. One specific interaction is supported by evidence stating that a specific interacting protein binds to the WH1 domain of the target protein. Which protein, connected to WAS through a binding relationship, is described by this evidence? | WAS/WASL-interacting protein family member 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05162","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene WAS is associated with multiple proteins via binding interactions. One specific interaction is supported by evidence stating that a specific... | |
medium_divergent_branch_05163 | OTUB1 interacts with multiple proteins. One specific interaction is characterized by the following mechanism: OTUB1 interacts with and deubiquitylates the partner protein on the K22 and K25 residues, a process demonstrated to be independent of OTUB1's catalytic activity. Which protein product is encoded by the gene cor... | Transforming growth factor-beta-induced protein ig-h3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05163","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"OTUB1 interacts with multiple proteins. One specific interaction is characterized by the following mechanism: OTUB1 interacts with and deubiquitylate... | |
medium_divergent_branch_05164 | ARMC12 interacts with multiple proteins. One specific interaction is described as follows: 'Mechanistically, the protein physically interacts with retinoblastoma binding protein 4 to facilitate the formation and activity of polycomb repressive complex 2, resulting in transcriptional repression of tumor suppressive gene... | Histone-binding protein RBBP4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05164","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARMC12 interacts with multiple proteins. One specific interaction is described as follows: 'Mechanistically, the protein physically interacts with re... | |
medium_divergent_branch_05165 | CXCL10 is associated with multiple biological processes. One specific association is supported by evidence that CXCL10, in combination with IL-2 and/or IFNα, induces apoptosis in T lymphocytes. Identify the broader biological process that is a parent term (via an 'is a' relationship) of the specific process linked to t... | regulation of programmed cell death | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05165","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CXCL10 is associated with multiple biological processes. One specific association is supported by evidence that CXCL10, in combination with IL-2 and/... | |
medium_divergent_branch_05166 | ETS1 is associated with multiple biological processes. One specific association is supported by evidence that hypoxia-induced down-regulation of miR-200b de-represses Ets-1 expression to promote angiogenesis. Which cell type is linked to this specific biological process via the 'enabled by cell' relationship? | circulating fibrocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05166","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ETS1 is associated with multiple biological processes. One specific association is supported by evidence that hypoxia-induced down-regulation of miR-... | |
medium_divergent_branch_05167 | EIF2B5 is associated with multiple biological processes. One specific association is supported by evidence showing that RNAi-mediated knockdown of EIF2B5 severely compromises the induction of GFAP-positive cells from normal human glial progenitors. Which broader biological process is a parent term (via an 'is a' relati... | glial cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05167","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EIF2B5 is associated with multiple biological processes. One specific association is supported by evidence showing that RNAi-mediated knockdown of EI... | |
medium_divergent_branch_05168 | FKBP4 interacts with multiple genes. One of these interacting partners is described in a study stating: 'Using glutathione-S transferase pull-down assays and immunoprecipitation, we have demonstrated that this protein and S100A2 specifically interact with the TPR domains of FKBP52 and CyP40 in a Ca(2+)-dependent manner... | irritable bowel syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05168","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FKBP4 interacts with multiple genes. One of these interacting partners is described in a study stating: 'Using glutathione-S transferase pull-down as... | |
medium_divergent_branch_05169 | ADAP1 interacts with multiple proteins. One of these interaction partners is supported by evidence stating that 'All groups of PKC associate directly through their cysteine rich domains.' Which protein is encoded by the gene corresponding to this specific interaction partner? | Protein kinase C iota type | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05169","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ADAP1 interacts with multiple proteins. One of these interaction partners is supported by evidence stating that 'All groups of PKC associate directly... | |
medium_divergent_branch_05170 | HMGA2 is associated with multiple biological processes. One association is supported by evidence stating: 'Our data lend support to the possibility that HMGA2 interacts with nucleosomes in a way that imposes a global effect on the state of ES cell chromatin, which may contribute to the establishment of both ES cell ide... | stem cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05170","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HMGA2 is associated with multiple biological processes. One association is supported by evidence stating: 'Our data lend support to the possibility t... | |
medium_divergent_branch_05171 | MCPH1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here, we identify cell division cycle protein 27, a component of the anaphase-promoting complex (APC/C), as a novel interacting partner of MCPH1.' Which protein is encoded by the gene that interacts with MCPH1 in this sp... | Cell division cycle protein 27 homolog | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05171","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MCPH1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here, we identify cell division cycle protein 27,... | |
medium_divergent_branch_05172 | AMFR interacts with multiple genes. One interaction is supported by evidence stating that 'Upregulation of Autocrine Motility Factor Receptor (AMFR), which is an E3-ubiquitin ligase of this gene, was also observed.' Which biological process is this gene involved in? | cholesterol biosynthetic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05172","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AMFR interacts with multiple genes. One interaction is supported by evidence stating that 'Upregulation of Autocrine Motility Factor Receptor (AMFR),... | |
medium_divergent_branch_05173 | hsa-miR-182-5p regulates more than one cell type. One line of evidence indicates that hsa-miR-182-5p, along with other miRNAs, is delivered into T cells to induce an exhaustion phenotype. Which cell type, connected to hsa-miR-182-5p via a 'regulates' relationship, is supported by this evidence? Identify the parent clas... | mature alpha-beta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05173","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"hsa-miR-182-5p regulates more than one cell type. One line of evidence indicates that hsa-miR-182-5p, along with other miRNAs, is delivered into T ce... | |
medium_divergent_branch_05174 | Human gammaherpesvirus 4 is reported to downregulate multiple genes. One specific downregulation event is characterized by a log2 fold change of approximately -1.12 and an adjusted p-value of 0.0472. Which cellular component is the target of this specific downregulation event located in? | extracellular space | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05174","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Human gammaherpesvirus 4 is reported to downregulate multiple genes. One specific downregulation event is characterized by a log2 fold change of appr... | |
medium_divergent_branch_05175 | NKX2-5 is associated with multiple biological processes. One association is supported by evidence stating: 'These data indicate that NKX2-5 is important for regulation of septation during cardiac morphogenesis and for maturation and maintenance of atrioventricular node function throughout life.' Which biological proces... | cardiac septum morphogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05175","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NKX2-5 is associated with multiple biological processes. One association is supported by evidence stating: 'These data indicate that NKX2-5 is import... | |
medium_divergent_branch_05176 | CSNK1D interacts with multiple proteins. One specific interaction partner is supported by evidence showing that CK1BP interacted with full-length Ckidelta, the isolated Ckidelta catalytic domain, Ckigamma2, -gamma3, and -epsilon in the yeast two-hybrid system, and bound Ckidelta and -epsilon in pulldown assays, but did... | Dysbindin domain-containing protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05176","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CSNK1D interacts with multiple proteins. One specific interaction partner is supported by evidence showing that CK1BP interacted with full-length Cki... | |
medium_divergent_branch_05177 | Pleiotrophin (PTN) is involved in multiple biological processes. One such process is supported by evidence that PTN-PTPRZ-A signaling controls the timing of oligodendrocyte precursor cell differentiation in vivo. Which biological process is positively regulated by this specific PTN-associated process? | oligodendrocyte differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05177","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Pleiotrophin (PTN) is involved in multiple biological processes. One such process is supported by evidence that PTN-PTPRZ-A signaling controls the ti... | |
medium_divergent_branch_05178 | SORBS1 interacts with multiple genes. One of these interaction partners was identified as CAP, a specific partner of a phosphatase proline-rich domain, through yeast two-hybrid, GST-pulldown, and coimmunoprecipitation studies, with the interaction confirmed to occur with the SH3C domain of CAP. Which disease is associa... | opsismodysplasia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05178","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SORBS1 interacts with multiple genes. One of these interaction partners was identified as CAP, a specific partner of a phosphatase proline-rich domai... | |
medium_divergent_branch_05179 | TOP3A interacts with multiple proteins. One specific interaction is characterized by the binding of the toroidal-shaped catalytic domain of TOP3β to the OB-fold domain of the partner protein. Which protein is this partner, and what protein product does the gene encoding this partner produce? | Tudor domain-containing protein 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05179","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TOP3A interacts with multiple proteins. One specific interaction is characterized by the binding of the toroidal-shaped catalytic domain of TOP3β to ... | |
medium_divergent_branch_05180 | PLD1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Using two-hybrid screens, we have identified a specific interactor as a PLD interactor that unexpectedly functions to alter its level of expression.' Which protein product is encoded by the gene corresponding to this spec... | Astrocytic phosphoprotein PEA-15 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05180","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PLD1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Using two-hybrid screens, we have identified a spe... | |
medium_divergent_branch_05181 | Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.421 and an adjusted p-value of 0.0459. Which protein does that selected gene encode? | Large ribosomal subunit protein uL1m | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05181","source_qa_id":"medium_divergent_branch_01661","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch sho... | |
medium_divergent_branch_05182 | The gene ATXN3 interacts with multiple partners. One specific interaction is supported by evidence stating: 'Five novel ataxin-3 interacting proteins were obtained, among which were three known proteins, namely human rhodopsin guanosine diphosphate dissociation inhibitor alpha, [PROTEIN_1], and human neuronal amiloride... | Small ubiquitin-related modifier 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05182","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ATXN3 interacts with multiple partners. One specific interaction is supported by evidence stating: 'Five novel ataxin-3 interacting proteins... | |
medium_divergent_branch_05183 | FGF1 is reported to interact with multiple proteins. One specific interaction is supported by evidence stating: 'Moreover, a binding assay in vitro with the use of recombinant FGF-1 and mortalin demonstrated a direct physical interaction between the two proteins.' Which protein is encoded by the gene corresponding to t... | Stress-70 protein, mitochondrial | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05183","source_qa_id":"medium_divergent_branch_06517","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"FGF1 is reported to interact with multiple proteins. One specific interaction is supported by evi... | |
medium_divergent_branch_05185 | MTOR interacts with multiple proteins. One specific interaction is described as follows: 'Here, we show that this protein binds to the TOR complex specifically, independently of its ability to bind TSC2, through separate interactions with the mTOR catalytic domain and with LST8.' Which protein, encoded by the gene conn... | GTP-binding protein Rheb | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05185","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MTOR interacts with multiple proteins. One specific interaction is described as follows: 'Here, we show that this protein binds to the TOR complex sp... | |
medium_divergent_branch_05186 | MMP2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'We present evidence for the first time of a specific, high affinity interaction between TIMP-4 and the C domain of human gelatinase A and show that TIMP-4 binds both progelatinase A and the C domain in a similar manner to th... | arteriovenous hemangioma/malformation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05186","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MMP2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'We present evidence for the first time of a specific,... | |
medium_divergent_branch_05187 | UBXN4 interacts with multiple genes. One of these interaction partners is confirmed to bind UBXN4 (erasin) via its UBX domain, as demonstrated by Immunoprecipitation and GST-pulldown experiments. Which disease is causally linked to this specific interaction partner? | lung carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05187","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBXN4 interacts with multiple genes. One of these interaction partners is confirmed to bind UBXN4 (erasin) via its UBX domain, as demonstrated by Imm... | |
medium_divergent_branch_05188 | MAP3K2 interacts with multiple proteins. One interaction is supported by evidence showing that the expression of JNK1, a MAP2K family member, and MEKK2 significantly augmented the coprecipitation of MEKK2-MAP2K family member, MEKK2-JNK1, and MAP2K family member-JNK1, indicating a synergistic interaction among these kin... | Dual specificity mitogen-activated protein kinase kinase 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05188","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP3K2 interacts with multiple proteins. One interaction is supported by evidence showing that the expression of JNK1, a MAP2K family member, and MEK... | |
medium_divergent_branch_05189 | mmu-miR-17-5p regulates more than one cell type. One specific regulatory interaction is supported by evidence showing that genetically engineered overexpression of the miR17/20a cluster in murine breast and colon cancer cells triggers recognition by a specific immune cell. This recognition occurs via the inhibition of ... | group 1 innate lymphoid cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05189","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"mmu-miR-17-5p regulates more than one cell type. One specific regulatory interaction is supported by evidence showing that genetically engineered ove... | |
medium_divergent_branch_05190 | RIPK2 interacts with multiple proteins. One specific interaction involves a member of the TNFR-associated factor (TRAF) family. Evidence indicates that RIP2 (RIPK2) interacts with TRAF1, TRAF5, and this specific entity, but does not interact with TRAF2, TRAF3, or TRAF4. Which disease is associated with this specific TR... | bone resorption disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05190","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RIPK2 interacts with multiple proteins. One specific interaction involves a member of the TNFR-associated factor (TRAF) family. Evidence indicates th... | |
medium_divergent_branch_05191 | SIX2 is associated with multiple biological processes. One association is supported by evidence showing that overexpression of SIX2 leads to a significantly higher percentage of cells in the S-phase and increased migration. Which anatomical entity participates in the biological process linked to this specific evidence? | migrating mesenchyme population | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05191","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SIX2 is associated with multiple biological processes. One association is supported by evidence showing that overexpression of SIX2 leads to a signif... | |
medium_divergent_branch_05192 | SMAD4 interacts with multiple proteins. One interaction involves a 30-zinc finger protein identified as a zinc finger protein, which associates with Smads in response to BMP2 to form a complex that transcriptionally activates the homeobox regulator Xvent-2. Which disease is genetically associated with this specific int... | lupus nephritis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05192","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMAD4 interacts with multiple proteins. One interaction involves a 30-zinc finger protein identified as a zinc finger protein, which associates with ... | |
medium_divergent_branch_05193 | TRAF6 interacts with multiple genes. One of these interacting partners has been shown to bind TRAF6 and disrupt the association between Beclin 1 and TRAF6, thereby inhibiting TRAF6-mediated ubiquitination of Beclin 1. Which disease is associated with this specific interacting gene via a biomarker relationship? | lung adenocarcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05193","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRAF6 interacts with multiple genes. One of these interacting partners has been shown to bind TRAF6 and disrupt the association between Beclin 1 and ... | |
medium_divergent_branch_05194 | STAM2 interacts with multiple proteins. One specific interaction is supported by evidence describing the crystal structure of the STAM2 SH3 domain in complex with a peptide derived from the ligand protein USP8. Which disease is associated with the gene encoding this ligand protein through genomic alterations? | ACTH-dependent Cushing syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05194","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"STAM2 interacts with multiple proteins. One specific interaction is supported by evidence describing the crystal structure of the STAM2 SH3 domain in... | |
medium_divergent_branch_05195 | FMR1 interacts with multiple proteins. One specific interaction was identified via a yeast two-hybrid assay, revealing a novel protein termed nuclear FMRP interacting protein. Which disease is associated with this specific interacting protein through genomic alterations? | microcephaly | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05195","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FMR1 interacts with multiple proteins. One specific interaction was identified via a yeast two-hybrid assay, revealing a novel protein termed nuclear... |
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