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medium_hidden_intermediate_01071 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in G alpha (q) signalling events. Experimental data for this gene shows a log2 fold change of -4.451 and an adjusted p-value of 0.04759. Which cellular component is this gene located in? | extracellular space | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01071","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in G alpha (q) signalling ... | |
medium_hidden_intermediate_01072 | Two genes are upregulated by Human immunodeficiency virus 1 and participate in the Adaptive Immune System. One of these genes shows a log2 fold change of approximately 2.93 and an adjusted p-value of 0.0068 in macrophages from study GSE108897. Which cell type is enriched for this specific gene? | mucosal-associated invariant T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01072","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and participate in the Adaptive Immune System. One of these gene... | |
medium_hidden_intermediate_01075 | In a study of Primate bocaparvovirus 1 infection, a gene is identified that is downregulated by the virus and participates in phospholipid metabolism. Evidence for this specific gene reports a log2 fold change of -1.027 and an adjusted p-value of 0.01242. Which protein is encoded by this gene? | Membrane-bound glycerophospholipid O-acyltransferase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01075","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Primate bocaparvovirus 1 infection, a gene is identified that is downregulated by the virus and participates i... | |
medium_hidden_intermediate_01076 | Two genes are identified as markers in mitotic fetal germ cells and are also linked to schizophrenia as biomarkers. One of these genes has been reported to demonstrate high sensitivity and specificity for the diagnosis of schizophrenia in female patients. Which disease is associated with this specific gene? | carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01076","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are identified as markers in mitotic fetal germ cells and are also linked to schizophrenia as biomarkers. One of t... | |
medium_hidden_intermediate_01077 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, which in turn binds to GRM8. This gene exhibited a log2 fold change of approximately 2.71 and an adjusted p-value of approximately 5.98e-05. Which protein is encoded by this gene? | Glutaminase liver isoform, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01077","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_01078 | Zika virus downregulates a specific gene that enables ATP binding. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -1.749 and an adjusted p-value of 0.03282. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01078","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that enables ATP binding. In a study of glioma stem cells (GSE114907), this gene ex... | |
medium_hidden_intermediate_01079 | Human alphaherpesvirus 1 upregulates a gene that interacts with PTEN. In a study of monocytic leukemia cell lines (GSE114966), one such gene exhibits a log2 fold change of 3.011 and an adjusted p-value of 0.002671. Which protein is encoded by this gene? | Lymphokine-activated killer T-cell-originated protein kinase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01079","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that interacts with PTEN. In a study of monocytic leukemia cell lines (GSE114966... | |
medium_hidden_intermediate_01082 | Severe acute respiratory syndrome-related coronavirus downregulates a gene located in the mitochondrial inner membrane. Evidence for this gene reports a log2 fold change of -1.387 and an adjusted p-value of 0.004948. Which protein is encoded by this gene? | Bcl-2-related ovarian killer protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01082","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene located in the mitochondrial inner membrane. Evid... | |
medium_hidden_intermediate_01084 | Two genes are downregulated by Pegivirus C and both enable DNA-binding transcription repressor activity, RNA polymerase II-specific. One of these genes exhibits a log2 fold change of -1.056 and an adjusted p-value of 0.003122 in peripheral blood mononuclear cells. Which cellular component is the location of this specif... | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01084","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and both enable DNA-binding transcription repressor activity, RNA polymerase II-s... | |
medium_hidden_intermediate_01085 | Two genes are each upregulated by Severe acute respiratory syndrome-related coronavirus and associated with melanoma. One of these genes was reported in a study (GSE148729) on a colonic adenocarcinoma cell line with a log2 fold change of approximately 1.558 and an adjusted p-value of approximately 0.0353. Which protein... | H2AZ2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01085","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each upregulated by Severe acute respiratory syndrome-related coronavirus and associated with melanoma. One of... | |
medium_hidden_intermediate_01086 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and involved in protein autoubiquitination was found to have a log2 fold change of 1.874 and an adjusted p-value of 7.362e-10. Which cellular component is this specific gene located in? | cytosol | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01086","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and involved in protein au... | |
medium_hidden_intermediate_01087 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the regulation of transcription by RNA polymerase II. Evidence for this gene reports a log2 fold change of 4.449 and an adjusted p-value of 0.0008118. Which disease is associated with this gene through genomic alterations? | preeclampsia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01087","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the regulation of transcri... | |
medium_hidden_intermediate_01088 | Zika virus downregulates a gene that participates in glycosaminoglycan metabolism. In glioma stem cells, one such gene exhibits a log2 fold change of -2.533 and an adjusted p-value of 0.005569. Which protein is encoded by this specific gene? | Beta-1,4-glucuronyltransferase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01088","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in glycosaminoglycan metabolism. In glioma stem cells, one such gene exhib... | |
medium_hidden_intermediate_01090 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the axoneme. Evidence for one such gene reports a log2 fold change of 1.164 and an adjusted p-value of 0.01042. Which protein is encoded by that gene? | Coiled-coil domain-containing protein 146 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01090","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the axoneme. Evidence for one su... | |
medium_hidden_intermediate_01091 | Zika virus downregulates a specific gene that enables p53 binding. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -2.50 and an adjusted p-value of approximately 0.043. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01091","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that enables p53 binding. Experimental data for this gene in glioma stem cells (stu... | |
medium_hidden_intermediate_01093 | A gene is upregulated by Vaccinia virus and participates in Asparagine N-linked glycosylation. Experimental data for this gene in a cervical adenocarcinoma cell line shows a log2 fold change of 3.708 and an adjusted p-value of 2.294e-15. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01093","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Vaccinia virus and participates in Asparagine N-linked glycosylation. Experimental data for this ge... | |
medium_hidden_intermediate_01094 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in intracellular calcium ion homeostasis. Evidence for this specific gene reports a log2 fold change of 2.334 and an adjusted p-value of 0.02038. Which molecular function is enabled by this gene? | chemokine activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01094","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in intracellular calcium ion homeo... | |
medium_hidden_intermediate_01095 | In a study of peripheral blood mononuclear cells (GSE131504), a gene is downregulated by Pegivirus C and binds to COG4. This gene exhibits a log2 fold change of -1.351 and an adjusted p-value of 0.02085. Which protein is encoded by this gene? | ADP-ribosylation factor-related protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01095","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of peripheral blood mononuclear cells (GSE131504), a gene is downregulated by Pegivirus C and binds to COG4. This... | |
medium_hidden_intermediate_01098 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Inositol phosphate metabolism. Evidence for one such gene reports a log2 fold change of 1.092 and an adjusted p-value of 0.003413. Which protein is encoded by that gene? | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01098","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Inositol phosphate metabolism.... | |
medium_hidden_intermediate_01100 | A gene is upregulated by Primate bocaparvovirus 1 and participates in Metabolism. Experimental evidence for this gene reports a log2 fold change of approximately 1.015 and an adjusted p-value of 0.0376. Which protein is encoded by this gene? | Long-chain-fatty-acid--CoA ligase 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01100","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and participates in Metabolism. Experimental evidence for this gene report... | |
medium_hidden_intermediate_01101 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that subsequently interacts with RAC1. One such gene exhibits a log2 fold change of 1.621 and an adjusted p-value of 0.006224. Which protein is encoded by this specific gene? | E3 ubiquitin-protein ligase SH3RF3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01101","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that subsequently interacts with RA... | |
medium_hidden_intermediate_01102 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables G protein-coupled receptor binding. Experimental data for this gene in lung cells shows a log2 fold change of approximately 2.68 and an adjusted p-value of 0.03755. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01102","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables G protein-coupled receptor bindin... | |
medium_hidden_intermediate_01103 | Influenza A virus downregulates a specific gene that participates in the Immune System. Experimental data for this gene reports a log2 fold change of -2.127 and an adjusted p-value of 2.072e-05. Which disease is associated with this gene as a biomarker? | lung neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01103","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Influenza A virus downregulates a specific gene that participates in the Immune System. Experimental data for this gene repo... | |
medium_hidden_intermediate_01104 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to vesicle via a 'located in' relationship. One of these genes has an associated expression profile showing a log2 fold change of -2.218 and an adjusted p-value of 0.009363. Which disease is... | urinary bladder carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01104","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_01106 | A gene is downregulated by Cardiovirus A and enriched in eosinophils. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of approximately -1.38 and an adjusted p-value of approximately 0.01. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01106","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Cardiovirus A and enriched in eosinophils. Experimental data for this gene in a cervical adenocar... | |
medium_hidden_intermediate_01107 | Two genes are downregulated by Human immunodeficiency virus 1 and participate in RAB geranylgeranylation. One of these genes exhibits a log2 fold change of -3.701 and an adjusted p-value of 0.0255 in macrophages. Which cell type is enriched for that specific gene? | mucosal-associated invariant T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01107","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Human immunodeficiency virus 1 and participate in RAB geranylgeranylation. One of these genes... | |
medium_hidden_intermediate_01110 | Two genes are downregulated by Vaccinia virus and interact with CDC42. One of these genes exhibits a log2 fold change of -1.795 and an adjusted p-value of 0.003482 in a specific study. Which cell type is this gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01110","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Vaccinia virus and interact with CDC42. One of these genes exhibits a log2 fold change of -1.... | |
medium_hidden_intermediate_01111 | Zika virus downregulates multiple genes that participate in the Toll Like Receptor 7/8 (TLR7/8) Cascade. One such gene exhibits a log2 fold change of -2.305 and an adjusted p-value of 0.01461 in glioma stem cells. Which protein is encoded by this specific gene? | Solute carrier family 15 member 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01111","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates multiple genes that participate in the Toll Like Receptor 7/8 (TLR7/8) Cascade. One such gene exhib... | |
medium_hidden_intermediate_01112 | Human immunodeficiency virus 1 upregulates a gene that is located in the endoplasmic reticulum. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of approximately 1.076 and an adjusted p-value of 0.0001997. Which protein is encoded by this specific gene? | E3 ubiquitin-protein ligase RNF19B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01112","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is located in the endoplasmic reticulum. In a study of macrophages (G... | |
medium_hidden_intermediate_01113 | Hepacivirus C upregulates a gene that enables sequence-specific double-stranded DNA binding. In a study of hepatocytes (GSE132606), one such gene showed a log2 fold change of approximately 1.026 and an adjusted p-value of 0.0001843. Which protein does this specific gene interact with? | PPP1CB | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01113","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that enables sequence-specific double-stranded DNA binding. In a study of hepatocytes (GSE1... | |
medium_hidden_intermediate_01118 | Zika virus downregulates a specific gene, which in turn binds to PIK3C2A. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -2.295 and an adjusted p-value of 0.01038. Which disease is associated with this gene as a biomarker? | breast carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01118","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn binds to PIK3C2A. Experimental data for this gene in glioma stem cel... | |
medium_hidden_intermediate_01120 | In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and binds to ITGB3. This gene exhibits a log2 fold change of 3.329 and an adjusted p-value of 0.008821. Which protein is encoded by this gene? | Adhesion G protein-coupled receptor A2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01120","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and binds to ITGB3. This gene... | |
medium_hidden_intermediate_01121 | A gene is connected to CREBBP via an 'interacts with' relationship and to DNA binding via an 'enables' relationship. Evidence concerning the protein product of this gene states: 'Furthermore, PKA treatment stimulates the association of the protein with CBP and increases its acetylation.' Which protein is encoded by thi... | Chorion-specific transcription factor GCMa | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01121","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is connected to CREBBP via an 'interacts with' relationship and to DNA binding via an 'enables' relationship. Evidenc... | |
medium_hidden_intermediate_01124 | Lepirudin and Deferasirox are linked via a shared interacting partner. Evidence indicates that in selected patients with HIT, the combination of lepirudin and this shared partner (along with tirofiban or eptifibatide) appears to be a safe and effective anticoagulation strategy for PCI. Which disease is this shared part... | intermediate coronary syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01124","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Lepirudin and Deferasirox are linked via a shared interacting partner. Evidence indicates that in selected patients with HIT... | |
medium_hidden_intermediate_01125 | Two genes are each upregulated by Severe acute respiratory syndrome-related coronavirus and associated with prostate cancer. One of these genes was reported in a study of non-small cell lung adenocarcinoma cell lines (GSE147507) with a log2 fold change of approximately 1.083 and an adjusted p-value of 0.002483. Which p... | ITCH | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01125","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each upregulated by Severe acute respiratory syndrome-related coronavirus and associated with prostate cancer.... | |
medium_hidden_intermediate_01126 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to the maturation of protein 3a via a participation relationship. One of these genes is associated with experimental data showing a log2 fold change of 2.454 and an adjusted p-value of 0.02634... | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01126","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship ... | |
medium_hidden_intermediate_01127 | Measles morbillivirus upregulates a gene that interacts with YWHAH. One such gene exhibits a log2 fold change of 2.127 and an adjusted p-value of 0.004164 in response to the virus. Which disease is associated with this gene as a biomarker? | non-small cell lung carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01127","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that interacts with YWHAH. One such gene exhibits a log2 fold change of 2.127 and a... | |
medium_hidden_intermediate_01128 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes involved in PI metabolism. One such gene exhibited a log2 fold change of 1.576 and an adjusted p-value of 6.906e-09. Which protein is encoded by this specific gene? | Phosphatidylinositol transfer protein beta isoform | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01128","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes... | |
medium_hidden_intermediate_01130 | Two genes are downregulated by Influenza A virus and enriched in memory B cells. One of these genes exhibits a log2 fold change of -1.103 and an adjusted p-value of 0.007473 in bronchial epithelial cells. Which disease is associated with this specific gene as a biomarker? | hepatocellular carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01130","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Influenza A virus and enriched in memory B cells. One of these genes exhibits a log2 fold cha... | |
medium_hidden_intermediate_01131 | Zika virus infection upregulates a specific gene in neural stem cells, which in turn enables identical protein binding. Transcriptomic data from study GSE129180 indicates this gene has a log2 fold change of 3.485 and an adjusted p-value of 0.006349. Which biological process is this gene involved in? | tight junction assembly | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01131","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection upregulates a specific gene in neural stem cells, which in turn enables identical protein binding. Tran... | |
medium_hidden_intermediate_01133 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in cholesterol biosynthesis. Evidence for one such gene reports a log2 fold change of -1.078 and an adjusted p-value of 0.008688. Which protein is encoded by that gene? | Isopentenyl-diphosphate Delta-isomerase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01133","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in cholesterol biosynthesis. Ev... | |
medium_hidden_intermediate_01134 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and to the process 'SARS-CoV-2 modulates host translation machinery' via a 'participates in' relationship. One of these genes is associated with experimental data showing a log2 fold change of ap... | Probable ATP-dependent RNA helicase DDX20 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01134","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship... | |
medium_hidden_intermediate_01135 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE148697), a specific gene is upregulated by the virus and its product is located in a receptor complex. This gene exhibits a log2 fold change of 5.748 and an adjusted p-value of 0.00126. Which protein is encoded by this gene... | Complement component receptor 1-like protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01135","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE148697), a specific gene is... | |
medium_hidden_intermediate_01136 | A gene is upregulated by Human immunodeficiency virus 1 and participates in Organelle biogenesis and maintenance. Evidence for this gene reports a log2 fold change of 1.500 and an adjusted p-value of 0.04441. Which disease is connected to this gene through genomic alterations? | steroid-responsive encephalopathy associated with autoimmune thyroiditis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01136","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human immunodeficiency virus 1 and participates in Organelle biogenesis and maintenance. Evidence f... | |
medium_hidden_intermediate_01137 | Human immunodeficiency virus 1 downregulates a gene that enables protein phosphatase regulator activity. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of -2.019 and an adjusted p-value of 0.002316. Which protein is encoded by this specific gene? | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01137","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that enables protein phosphatase regulator activity. In a study of macro... | |
medium_hidden_intermediate_01138 | Zika virus downregulates a gene that interacts with HIST1H4A. In glioma stem cells, one such gene exhibits a log2 fold change of -1.744 and an adjusted p-value of 0.02348. Which protein is encoded by this gene? | Sex comb on midleg-like protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01138","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with HIST1H4A. In glioma stem cells, one such gene exhibits a log2 fold chang... | |
medium_hidden_intermediate_01139 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, which in turn interacts with SNRPD2. This gene exhibited a log2 fold change of approximately 2.975 and an adjusted p-value of 1.36e-05. Which protein is encoded by this upregulated gene? | ATP-binding cassette sub-family F member 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01139","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_01144 | Human immunodeficiency virus 1 upregulates a gene that participates in Signaling by Rho GTPases. Evidence for this gene in macrophages (study GSE108897) reports a log2 fold change of 1.066 and an adjusted p-value of 0.00415. Which gene interacts with this upregulated gene? | RAB11A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01144","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in Signaling by Rho GTPases. Evidence for this gene in m... | |
medium_hidden_intermediate_01145 | Hepacivirus C downregulates a gene that enables G protein-coupled receptor activity. Evidence for one such gene reports a log2 fold change of -1.276 and an adjusted p-value of 6.802e-06. Which biological process is this gene involved in? | negative regulation of interleukin-2 production | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01145","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a gene that enables G protein-coupled receptor activity. Evidence for one such gene reports a lo... | |
medium_hidden_intermediate_01146 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and involved in the positive regulation of interleukin-10 production. Evidence for this gene reports a log2 fold change of 4.721 and an adjusted p-value of 0.01109. Which protein is encoded by this gene? | Interleukin-27 subunit beta | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01146","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and involved i... | |
medium_hidden_intermediate_01148 | Human immunodeficiency virus 1 is reported to downregulate a gene that is involved in signal transduction. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of -2.872 and an adjusted p-value of 0.0002584. Which protein is encoded by this specific gene? | Thyrotropin-releasing hormone-degrading ectoenzyme | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01148","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 is reported to downregulate a gene that is involved in signal transduction. In a study of mac... | |
medium_hidden_intermediate_01149 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that subsequently binds to SERP1. One such gene exhibits a log2 fold change of approximately 1.005 and an adjusted p-value of 0.001479. Which protein is encoded by this specific gene? | Guided entry of tail-anchored proteins factor CAMLG | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01149","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that subsequently binds to SERP1. O... | |
medium_hidden_intermediate_01150 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the upregulation of certain genes that subsequently interact with STAU1. One such gene exhibits a log2 fold change of 1.715 and an adjusted p-value of 2.642e-07. Which protein does this specific upregulated gene bind to? | RNASEL | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01150","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the upregulation of certain g... | |
medium_hidden_intermediate_01152 | HNRNPK interacts with a protein that is located in the plasma membrane. Evidence indicates that the myristoylation of this specific protein results in its association with the plasma membrane. Which protein is encoded by the gene corresponding to this entity? | Protein arginine N-methyltransferase 8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01152","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"HNRNPK interacts with a protein that is located in the plasma membrane. Evidence indicates that the myristoylation of this s... | |
medium_hidden_intermediate_01154 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and to PTEN Regulation via a 'participates in' relationship. One of these genes is reported in a study of bronchial epithelial cells (GSE150819) with a log2 fold change of approximately 2.75 and ... | lung cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01154","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship... | |
medium_hidden_intermediate_01155 | Rhinovirus A infection leads to the downregulation of certain genes involved in the defense response. One such gene exhibits a log2 fold change of -3.771 and an adjusted p-value of 0.0003512 in cytotoxic T-lymphocytes. Which protein is encoded by this specific gene? | Interferon-induced GTP-binding protein Mx2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01155","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection leads to the downregulation of certain genes involved in the defense response. One such gene exhibits... | |
medium_hidden_intermediate_01156 | Hepacivirus C upregulates a gene that participates in TCF dependent signaling in response to WNT. Evidence for one such gene reports a log2 fold change of 1.318 and an adjusted p-value of 0.001372. Which disease is associated with that gene as a biomarker? | ganglioglioma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01156","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in TCF dependent signaling in response to WNT. Evidence for one such gene... | |
medium_hidden_intermediate_01157 | A gene is upregulated by Human gammaherpesvirus 8 and is involved in the apoptotic process. Experimental evidence for this gene reports a log2 fold change of approximately 1.088 and an adjusted p-value of 0.03791. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01157","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human gammaherpesvirus 8 and is involved in the apoptotic process. Experimental evidence for this g... | |
medium_hidden_intermediate_01158 | A gene is upregulated by Primate bocaparvovirus 1 and is enriched in eosinophils. Transcriptomic data for this gene reports a log2 fold change of approximately 1.025 and an adjusted p-value of 0.0354. Which protein is encoded by this gene? | Grancalcin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01158","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and is enriched in eosinophils. Transcriptomic data for this gene reports ... | |
medium_hidden_intermediate_01159 | Hepacivirus C is associated with the upregulation of a gene that serves as a biomarker for bipolar disorder. One such gene exhibits a log2 fold change of 3.348 and an adjusted p-value of 0.003935 in hepatocytes. Which protein is encoded by this gene? | Neurosecretory protein VGF | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01159","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is associated with the upregulation of a gene that serves as a biomarker for bipolar disorder. One such gene e... | |
medium_hidden_intermediate_01160 | Human betaherpesvirus 5 upregulates a gene that participates in transcriptional regulation by RUNX1. Evidence for this gene in foreskin fibroblast cell lines reports a log2 fold change of approximately 1.20 and an adjusted p-value of approximately 0.0037. Which disease is associated with this gene? | rheumatoid arthritis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01160","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that participates in transcriptional regulation by RUNX1. Evidence for this gene ... | |
medium_hidden_intermediate_01161 | Two genes are linked to Human immunodeficiency virus 1 via an upregulation relationship and to uveal melanoma via an association relationship. One of these genes exhibits a log2 fold change of approximately 2.70 and an adjusted p-value of approximately 0.0008 in macrophages (study GSE108897). Which biological process i... | melanosome organization | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01161","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Human immunodeficiency virus 1 via an upregulation relationship and to uveal melanoma via an associa... | |
medium_hidden_intermediate_01162 | Pegivirus C is linked to peritonitis via a gene that it downregulates and which is associated with the condition. One such gene exhibits a log2 fold change of -1.081 and an adjusted p-value of 0.009809 in peripheral blood mononuclear cells. Which protein is encoded by this specific gene? | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01162","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is linked to peritonitis via a gene that it downregulates and which is associated with the condition. One such g... | |
medium_hidden_intermediate_01163 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables ubiquitin-like ligase-substrate adaptor activity. Experimental data for this gene reports a log2 fold change of approximately 1.013 and an adjusted p-value of 0.007199. Which protein is encoded by this gene? | Protein fem-1 homolog B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01163","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables ubiquitin-like ligase-substrate a... | |
medium_hidden_intermediate_01165 | Human immunodeficiency virus 1 downregulates a specific gene that is enriched in naive CD4+ T cells. Evidence for this gene reports a log2 fold change of -5.023 and an adjusted p-value of 0.02423. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01165","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a specific gene that is enriched in naive CD4+ T cells. Evidence for this gene ... | |
medium_hidden_intermediate_01166 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes that are involved in the positive regulation of gene expression. One such gene exhibits a log2 fold change of -1.128 and an adjusted p-value of 0.04624. Which protein is encoded by this specific gene? | Transcriptional adapter 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01166","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes that ... | |
medium_hidden_intermediate_01168 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and serve as biomarkers for ovarian cancer. One of these genes exhibits a log2 fold change of approximately 1.16 and an adjusted p-value of 0.0124 in lung tissue data. Which disease is associated with this specific gene through genomic a... | rheumatoid arthritis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01168","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and serve as biomarkers for ovarian cance... | |
medium_hidden_intermediate_01169 | Human betaherpesvirus 5 is reported to upregulate a gene that is located in the membrane raft. Experimental evidence for this specific gene shows a log2 fold change of approximately 1.14 and an adjusted p-value of 0.047. Which protein is encoded by this gene? | Phospholipid phosphatase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01169","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to upregulate a gene that is located in the membrane raft. Experimental evidence for thi... | |
medium_hidden_intermediate_01170 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the regulation of cell population proliferation. Evidence for this gene reports a log2 fold change of -1.193 and an adjusted p-value of 0.001694. Which disease is associated with this gene as a biomarker? | adult glioblastoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01170","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the regulation of cell p... | |
medium_hidden_intermediate_01172 | A gene serves as a marker for Natural killer cells and is enriched in Intermediate monocytes. Evidence for this gene includes a mean expression of 419.37 TPM, a z-score of 1.90, and a fold enrichment of 3.21. Which biological process is this gene involved in? | muscle organ development | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01172","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for Natural killer cells and is enriched in Intermediate monocytes. Evidence for this gene include... | |
medium_hidden_intermediate_01173 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that is located in the melanosome. One such gene exhibits a log2 fold change of approximately 2.70 and an adjusted p-value of approximately 0.0008. Which biological process is this specific gene involved in? | melanosome organization | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01173","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that is located in the melanosome. ... | |
medium_hidden_intermediate_01175 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in turn encodes a protein that binds to SRC. The expression data for this gene shows a log2 fold change of approximately -1.68 and an adjusted p-value of 0.0014. Which protein is encoded by this gene? | Actin-binding LIM protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01175","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in tu... | |
medium_hidden_intermediate_01177 | In a study of Hepacivirus C infection, a specific gene is downregulated by the virus and is associated with leukemia. Experimental data for this gene in peripheral blood mononuclear cells (from study GSE119117) show a log2 fold change of -1.775 and an adjusted p-value of 0.003552. What molecular function is enabled by ... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01177","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Hepacivirus C infection, a specific gene is downregulated by the virus and is associated with leukemia. Experi... | |
medium_hidden_intermediate_01178 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, two genes are upregulated and participate in the Toll Like Receptor 10 (TLR10) Cascade. One of these genes exhibits a log2 fold change of 1.858 and an adjusted p-value of 1.68e-09. Which biological process is this specific gene invo... | negative regulation of canonical NF-kappaB signal transduction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01178","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, two genes are upregulated and partic... | |
medium_hidden_intermediate_01179 | A gene expressed in Follicular B cells and associated with protein binding function is the subject of a study stating: 'Here, an exoribonuclease, PNPase, was identified in a complex with the protein encoded by this gene.' Which protein is encoded by this gene? | T-cell leukemia/lymphoma protein 1A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01179","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene expressed in Follicular B cells and associated with protein binding function is the subject of a study stating: 'Here... | |
medium_hidden_intermediate_01180 | Pegivirus C is linked to UBE2M via an intermediate gene that it downregulates, which in turn interacts with UBE2M. One such intermediate gene exhibits a log2 fold change of -2.241 and an adjusted p-value of 0.0001853 in peripheral blood mononuclear cells. Which protein is encoded by this specific intermediate gene? | DCN1-like protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01180","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is linked to UBE2M via an intermediate gene that it downregulates, which in turn interacts with UBE2M. One such ... | |
medium_hidden_intermediate_01181 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which is located in the nuclear replication fork. This gene exhibits a log2 fold change of -1.384 and an adjusted p-value of 0.01077. Which protein is encoded by this gene? | DNA annealing helicase and endonuclease ZRANB3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01181","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_01182 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Glycerophospholipid biosynthesis. Evidence for this specific gene reports a log2 fold change of 1.304 and an adjusted p-value of 4.598e-09. Which protein is encoded by this gene? | Phosphatidate cytidylyltransferase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01182","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Glycerophospholipid biosynthes... | |
medium_hidden_intermediate_01183 | Human betaherpesvirus 5 is associated with the upregulation of a gene that is enriched in intermediate monocytes. Evidence for this specific gene reports a log2 fold change of approximately 2.49 and an adjusted p-value of approximately 0.0336. Which protein is encoded by this gene? | Interferon-induced protein 44-like | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01183","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is associated with the upregulation of a gene that is enriched in intermediate monocytes. Evidence f... | |
medium_hidden_intermediate_01184 | In a study of sclera cells (GSE164073), Severe acute respiratory syndrome-related coronavirus was found to upregulate a gene that subsequently interacts with CDC42. One such gene exhibited a log2 fold change of 5.940 and an adjusted p-value of 0.008327. Which cellular component is this specific gene located in? | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01184","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of sclera cells (GSE164073), Severe acute respiratory syndrome-related coronavirus was found to upregulate a gene... | |
medium_hidden_intermediate_01187 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in proteolysis. Evidence for one such gene reports a log2 fold change of -1.070 and an adjusted p-value of 0.003924. Which molecular function is enabled by that gene? | metalloendopeptidase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01187","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in proteolysis. Evidence for one... | |
medium_hidden_intermediate_01188 | Two distinct drugs serve as intermediates in a two-step interaction pathway starting from Erythromycin and ending at Apalutamide. One of these intermediate drugs is associated with evidence stating: 'There are pharmacological interactions between these drugs and other medications metabolized by the cytochrome P450 (P3A... | erectile dysfunction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01188","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct drugs serve as intermediates in a two-step interaction pathway starting from Erythromycin and ending at Apaluta... | |
medium_hidden_intermediate_01190 | Vaccinia virus downregulates a gene that is involved in fat cell differentiation. In a study of cervical adenocarcinoma cell lines (GSE11238), one such gene exhibits a log2 fold change of -1.598 and an adjusted p-value of 0.0002044. Which protein is encoded by this specific gene? | Complement C1q tumor necrosis factor-related protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01190","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus downregulates a gene that is involved in fat cell differentiation. In a study of cervical adenocarcinoma cell... | |
medium_hidden_intermediate_01193 | In a study of non-small cell lung adenocarcinoma cell lines infected with Influenza A virus, a specific gene was found to be upregulated and involved in phospholipid metabolism. This gene exhibited a log2 fold change of approximately 1.344 and an adjusted p-value of 2.145e-10. Which disease is associated with this gene... | primary myelofibrosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01193","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines infected with Influenza A virus, a specific gene was found to be... | |
medium_hidden_intermediate_01194 | Human betaherpesvirus 5 upregulates a gene that participates in Developmental Biology. Evidence for this gene reports a log2 fold change of 1.186 and an adjusted p-value of 0.0005056. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01194","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that participates in Developmental Biology. Evidence for this gene reports a log2... | |
medium_hidden_intermediate_01197 | Zika virus downregulates a specific gene that is involved in the regulation of DNA-templated transcription. Experimental data from glioma stem cells (study GSE114907) indicates this gene has a log2 fold change of -1.986 and an adjusted p-value of 0.006285. Which disease is associated with this gene as a biomarker? | ganglioglioma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01197","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is involved in the regulation of DNA-templated transcription. Experimental dat... | |
medium_hidden_intermediate_01202 | Zika virus downregulates a gene that participates in Chromosome Maintenance. In a study of glioma stem cells (GSE114907), one such gene exhibits a log2 fold change of approximately -2.36 and an adjusted p-value of 0.0075. Which protein is encoded by this specific gene? | Histone H3-like centromeric protein A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01202","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in Chromosome Maintenance. In a study of glioma stem cells (GSE114907), on... | |
medium_hidden_intermediate_01203 | In a study of vascular endothelial cells (GSE16354), a gene is identified as being downregulated by Human gammaherpesvirus 8 and involved in the regulation of transcription by RNA polymerase II. This specific gene exhibits a log2 fold change of -1.219 and an adjusted p-value of 0.0002767. Which protein is encoded by th... | Transcription factor JunD | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01203","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of vascular endothelial cells (GSE16354), a gene is identified as being downregulated by Human gammaherpesvirus 8... | |
medium_hidden_intermediate_01204 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific gene, which in turn enables RNA polymerase II cis-regulatory region sequence-specific DNA binding. This gene exhibited a log2 fold change of approximately -1.445 and an adjusted p-value of 0.01961.... | Zinc finger protein 644 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01204","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific g... | |
medium_hidden_intermediate_01207 | Enterovirus A is linked to breast carcinoma via a gene that acts as a biomarker and is upregulated by the virus. One such gene exhibits a log2 fold change of 2.206 and an adjusted p-value of 0.003093 in rhabdomyosarcoma cells. Which protein is encoded by this specific gene? | Forkhead box protein Q1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01207","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is linked to breast carcinoma via a gene that acts as a biomarker and is upregulated by the virus. One such ge... | |
medium_hidden_intermediate_01208 | A gene is downregulated by Vaccinia virus and located in the lysosomal membrane. Evidence for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of -2.100 and an adjusted p-value of 0.006827. Which disease is associated with this gene? | cardiac sarcoidosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01208","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Vaccinia virus and located in the lysosomal membrane. Evidence for this gene in a cervical adenoc... | |
medium_hidden_intermediate_01209 | A gene is downregulated by Primate bocaparvovirus 1 and is enriched in non-classical monocytes. Transcriptomic evidence for this gene shows a log2 fold change of -1.500 and an adjusted p-value of 0.003693. Which protein is encoded by this gene? | Cysteine/serine-rich nuclear protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01209","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and is enriched in non-classical monocytes. Transcriptomic evidence for ... | |
medium_hidden_intermediate_01210 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a specific gene that participates in Interferon gamma signaling. This gene exhibited a log2 fold change of approximately 1.600 and an adjusted p-value of 0.0006677. Which protein is encoded by this gene? | E3 ubiquitin-protein ligase TRIM34 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01210","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a specific gene tha... | |
medium_hidden_intermediate_01211 | Two genes are upregulated by Vaccinia virus and bind to TMEM126B. One of these genes exhibits a log2 fold change of 1.531 and an adjusted p-value of 8.97e-08 in cervical adenocarcinoma cell lines. Which disease is associated with this specific gene? | mitochondrial complex I deficiency, nuclear type 39 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01211","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and bind to TMEM126B. One of these genes exhibits a log2 fold change of 1.531 an... | |
medium_hidden_intermediate_01212 | Human immunodeficiency virus 1 downregulates a gene that is located in the ciliary basal body. Evidence for this gene reports a log2 fold change of -1.432 and an adjusted p-value of 0.007496. Which protein is encoded by this gene? | POC1 centriolar protein homolog A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01212","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is located in the ciliary basal body. Evidence for this gene report... | |
medium_hidden_intermediate_01215 | Human immunodeficiency virus 1 downregulates a gene that is located in the mitochondrial inner membrane. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately -1.06 and an adjusted p-value of 0.0063. Which protein is encoded by this gene? | Mitochondrial import inner membrane translocase subunit Tim21 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01215","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is located in the mitochondrial inner membrane. In a study of macro... | |
medium_hidden_intermediate_01216 | Zika virus downregulates a gene involved in mRNA pseudouridine synthesis. In a study of glioma stem cells (GSE114907), one such gene showed a log2 fold change of -1.404 and an adjusted p-value of 0.04933. Which protein is encoded by this specific gene? | Pseudouridylate synthase RPUSD2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01216","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene involved in mRNA pseudouridine synthesis. In a study of glioma stem cells (GSE114907), one s... | |
medium_hidden_intermediate_01219 | Hepacivirus C upregulates a gene that is involved in protein ubiquitination. Experimental data for this gene reports a log2 fold change of 1.422 and an adjusted p-value of 0.0335. Which protein is encoded by this gene? | E3 ubiquitin-protein ligase RNF182 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01219","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in protein ubiquitination. Experimental data for this gene reports a log2 ... | |
medium_hidden_intermediate_01221 | A gene is downregulated by Vaccinia virus and located in the extracellular space. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of -3.954 and an adjusted p-value of 0.01364. Which disease is associated with this gene through genomic alterations? | coronary artery disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01221","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Vaccinia virus and located in the extracellular space. Experimental data for this gene in a cervi... | |
medium_hidden_intermediate_01224 | In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and its protein product interacts with BRCA1. One such gene exhibits a log2 fold change of approximately 1.003 and an adjusted p-value of 0.04505. Which protein is encoded by this specific gene? | Ubiquitin-conjugating enzyme E2 W | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01224","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and its protein... |
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