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medium_hidden_intermediate_01225 | Two genes are upregulated by Vaccinia virus and both bind to MT-CO1. One of these genes exhibits a log2 fold change of 3.152 and an adjusted p-value of 9.619e-14 in cervical adenocarcinoma cell lines. Which disease is associated with this specific gene? | mitochondrial complex IV deficiency, nuclear type 20 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01225","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and both bind to MT-CO1. One of these genes exhibits a log2 fold change of 3.152... | |
medium_hidden_intermediate_01227 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the regulation of endogenous retroelements. Evidence for this gene reports a log2 fold change of 1.110 and an adjusted p-value of 0.01557. Which protein is encoded by this gene? | Zinc finger protein 136 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01227","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the regulation of endogenous r... | |
medium_hidden_intermediate_01228 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in intracellular signal transduction. Evidence for this specific gene reports a log2 fold change of approximately 3.004 and an adjusted p-value of 0.01077. Which cellular component is this gene located in? | nucleolus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01228","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in intracellular signal transducti... | |
medium_hidden_intermediate_01229 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with RBBP4. Evidence for this gene reports a log2 fold change of 1.026 and an adjusted p-value of 0.01821. In which cell type is this gene enriched? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01229","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with RBBP4. Evidence for this g... | |
medium_hidden_intermediate_01230 | Two genes are upregulated by Human alphaherpesvirus 3 and enriched in basophils. One of these genes shows a log2 fold change of 1.512 and an adjusted p-value of 1.185e-06 in a melanoma cell line study (GSE136586). Which disease is associated with this specific gene? | neurodevelopmental disorder with spasticity, thin corpus callosum, and decreased brain white matter | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01230","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human alphaherpesvirus 3 and enriched in basophils. One of these genes shows a log2 fold change... | |
medium_hidden_intermediate_01232 | In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to upregulate a specific gene, which is involved in the regulation of the cell cycle process. This gene exhibited a log2 fold change of 1.009 and an adjusted p-value of 0.02891. Which protein is encoded ... | Ubiquitin carboxyl-terminal hydrolase 51 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01232","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to upre... | |
medium_hidden_intermediate_01233 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to depressive disorder via an 'associated with' relationship. One of these genes is reported in a study (GSE164073) involving corneal epithelium cells, showing a log2 fold change of approxim... | Hepcidin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01233","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_01234 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is downregulated by the virus and participates in the innate immune system. This gene exhibits a log2 fold change of approximately -1.005 and an adjusted p-value of 0.008191. Which protein is encoded by this gene? | Thiol S-methyltransferase TMT1A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01234","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is downregulated by ... | |
medium_hidden_intermediate_01235 | Two genes are upregulated by Vaccinia virus and interact with ANLN. One of these genes shows a log2 fold change of 1.779 and an adjusted p-value of 1.309e-06 in cervical adenocarcinoma cell lines. In which cell type is this specific gene enriched? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01235","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and interact with ANLN. One of these genes shows a log2 fold change of 1.779 and... | |
medium_hidden_intermediate_01236 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that enables galactosyltransferase activity. This specific gene exhibited a log2 fold change of -1.258 and an adjusted p-value of 0.001489. Which protein is encoded by this gene? | Beta-1,4-galactosyltransferase 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01236","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that enables galactos... | |
medium_hidden_intermediate_01237 | In a study of cardiomyocyte cell lines (GSE151879), a gene upregulated by Severe acute respiratory syndrome-related coronavirus and involved in protein phosphorylation was found to have a log2 fold change of 1.320 and an adjusted p-value of 0.00602. Which disease is associated with this gene as a biomarker? | colorectal carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01237","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cardiomyocyte cell lines (GSE151879), a gene upregulated by Severe acute respiratory syndrome-related coronavi... | |
medium_hidden_intermediate_01239 | Two genes are structurally linked to Enterovirus A via an upregulation relationship and to classical monocytes via an enrichment relationship. One of these genes has a reported log2 fold change of 1.758 and an adjusted p-value of 0.02521. Which biological process is associated with this specific gene through an 'involv... | lysosomal protein catabolic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01239","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Enterovirus A via an upregulation relationship and to classical monocytes via an enrich... | |
medium_hidden_intermediate_01242 | Hepacivirus C upregulates a gene that enables sequence-specific double-stranded DNA binding. Experimental data for this gene reports a log2 fold change of approximately 1.11 and an adjusted p-value of approximately 2.29e-08. Which gene interacts with this upregulated gene? | ZSCAN32 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01242","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that enables sequence-specific double-stranded DNA binding. Experimental data for this gene... | |
medium_hidden_intermediate_01243 | A specific gene product is linked to Myeloid conventional dendritic cells via a 'has marker' relationship and is associated with 'signaling receptor activity' via an 'enables' relationship. Contextual evidence identifies this entity as a triggering receptor expressed on myeloid cells that is selectively expressed on bl... | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01243","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A specific gene product is linked to Myeloid conventional dendritic cells via a 'has marker' relationship and is associated ... | |
medium_hidden_intermediate_01244 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection leads to the downregulation of a specific gene, which in turn encodes a protein that binds to MYD88. The expression data for this gene shows a log2 fold change of approximately -1.086 and an adjusted p-value of 0.007722. Which protein... | Interleukin-1 alpha | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01244","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_01245 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by the virus and its product enables kinase binding. This gene exhibits a log2 fold change of 2.047 and an adjusted p-value of 0.0009981. Which protein is encoded by this gene? | Growth arrest and DNA damage-inducible protein GADD45 alpha | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01245","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by th... | |
medium_hidden_intermediate_01246 | In a study of macrophages (GSE108897), a gene upregulated by Human immunodeficiency virus 1 and capable of sequence-specific double-stranded DNA binding was found to have a log2 fold change of approximately 1.19 and an adjusted p-value of approximately 0.036. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01246","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene upregulated by Human immunodeficiency virus 1 and capable of sequence-specific... | |
medium_hidden_intermediate_01247 | Two genes are structurally linked to Pegivirus C via downregulation and to the maturation of spike protein via participation. One of these genes exhibits a log2 fold change of -1.087 and an adjusted p-value of 0.04669 in peripheral blood mononuclear cells. Which cellular component is the location of this specific gene? | Golgi membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01247","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Pegivirus C via downregulation and to the maturation of spike protein via participation... | |
medium_hidden_intermediate_01252 | In a study of bronchial epithelial cells (GSE150819), Severe acute respiratory syndrome-related coronavirus was found to upregulate a specific gene, which in turn interacts with PRNP. This gene exhibited a log2 fold change of 3.267 and an adjusted p-value of 0.0246. What molecular function is enabled by this upregulate... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01252","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of bronchial epithelial cells (GSE150819), Severe acute respiratory syndrome-related coronavirus was found to upr... | |
medium_hidden_intermediate_01254 | Enterovirus A infection leads to the upregulation of certain genes whose protein products are located on the cell surface. In a study of rhabdomyosarcoma cells (GSE103308), one such upregulated gene exhibited a log2 fold change of approximately 2.12 and an adjusted p-value of 0.034. Which protein is encoded by this spe... | UL16-binding protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01254","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A infection leads to the upregulation of certain genes whose protein products are located on the cell surface. I... | |
medium_hidden_intermediate_01256 | A gene is downregulated by Zika virus and enriched in naive B cells. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.27 and an adjusted p-value of approximately 0.044. Which protein is encoded by this gene? | Zinc finger protein 395 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01256","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Zika virus and enriched in naive B cells. Experimental data for this gene in glioma stem cells (s... | |
medium_hidden_intermediate_01258 | Pegivirus C is reported to downregulate a gene that is involved in the positive regulation of transcription by RNA polymerase II. Experimental data from a study on peripheral blood mononuclear cells (GSE131504) indicates that this specific gene has a log2 fold change of -1.056 and an adjusted p-value of 0.003122. Which... | Zinc finger protein 263 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01258","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in the positive regulation of transcription by RNA polymeras... | |
medium_hidden_intermediate_01259 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in nervous system development. Evidence for this gene reports a log2 fold change of approximately 6.13 and an adjusted p-value of 0.04192. Which protein is encoded by this gene? | Protocadherin-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01259","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in nervous system development... | |
medium_hidden_intermediate_01263 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the epigenetic regulation of gene expression. Evidence for this gene reports a log2 fold change of 1.118 and an adjusted p-value of 3.222e-05. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01263","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the epigenetic regulation of g... | |
medium_hidden_intermediate_01265 | Rhinovirus A upregulates a specific gene that participates in gene expression (transcription). Evidence for this gene reports a log2 fold change of approximately 1.098 and an adjusted p-value of approximately 0.01052. In which cell type is this gene enriched? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01265","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A upregulates a specific gene that participates in gene expression (transcription). Evidence for this gene report... | |
medium_hidden_intermediate_01267 | Pegivirus C is reported to downregulate a gene that subsequently interacts with SRPK2. Experimental data for this intermediate gene in peripheral blood mononuclear cells (from study GSE131504) indicates a log2 fold change of approximately -1.56 and an adjusted p-value of approximately 0.0057. Which protein is encoded b... | Cyclin-dependent kinase 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01267","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that subsequently interacts with SRPK2. Experimental data for this intermedia... | |
medium_hidden_intermediate_01268 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and involved in calcium import into the mitochondrion. Evidence for this gene reports a log2 fold change of approximately 1.105 and an adjusted p-value of 8.404e-06. Which protein is encoded by this ge... | Calcium uptake protein 2, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01268","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and i... | |
medium_hidden_intermediate_01271 | Two genes are each upregulated by Severe acute respiratory syndrome-related coronavirus and associated with squamous cell carcinoma. One of these genes was reported in a study (GSE164073) involving sclera cells, with a log2 fold change of approximately 1.174 and an adjusted p-value of 0.002558. Which gene interacts wit... | CDK1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01271","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each upregulated by Severe acute respiratory syndrome-related coronavirus and associated with squamous cell ca... | |
medium_hidden_intermediate_01272 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with glioma. One of these genes exhibits a log2 fold change of -1.456 and an adjusted p-value of 0.01083 in a specific study. Which cellular component is the location of this specific gene? | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01272","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with glioma. One of ... | |
medium_hidden_intermediate_01273 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection was found to downregulate certain genes that participate in GPCR signaling. One such gene exhibited a log2 fold change of -1.155 and an adjusted p-value of 0.0132. Which protein is encoded by this specific gene? | C-C motif chemokine 20 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01273","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection was found to downregulate certain gene... | |
medium_hidden_intermediate_01275 | In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and participates in Developmental Biology. This specific gene exhibits a log2 fold change of approximately -4.71 and an adjusted p-value of approximately 0.0056. What molecular function is enabled by this... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01275","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and part... | |
medium_hidden_intermediate_01276 | Zika virus downregulates a gene that interacts with PTP4A2. In glioma stem cells (study GSE114907), one such gene exhibits a log2 fold change of approximately -3.20 and an adjusted p-value of 0.002154. Which protein is encoded by this gene? | Metal transporter CNNM3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01276","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with PTP4A2. In glioma stem cells (study GSE114907), one such gene exhibits a... | |
medium_hidden_intermediate_01277 | Hepacivirus C is reported to downregulate a specific gene, which in turn interacts with YWHAE. Experimental data for this gene shows a log2 fold change of approximately -1.37 and an adjusted p-value of 0.0062. Which protein is encoded by this gene? | Phosphatidate phosphatase LPIN3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01277","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a specific gene, which in turn interacts with YWHAE. Experimental data for this ge... | |
medium_hidden_intermediate_01278 | Pegivirus C is reported to downregulate a gene that is involved in membrane fission. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.574 and an adjusted p-value of 0.02102. Which protein is encoded by this specific gene? | Exocyst complex component 6B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01278","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in membrane fission. In a study of peripheral blood mononucl... | |
medium_hidden_intermediate_01279 | In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and participates in Transcriptional Regulation by NPAS4. This specific gene exhibits a log2 fold change of -2.911 and an adjusted p-value of 0.008217. Which cellular component is this gene located in? | perinuclear region of cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01279","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and part... | |
medium_hidden_intermediate_01283 | Two genes are structurally positioned between Pegivirus C and CRY2, linked by a downregulation event from the virus and a binding interaction with CRY2. One of these genes exhibits a log2 fold change of -1.625 and an adjusted p-value of 0.01293 in a specific study. Which cell type is this gene enriched in? | non-classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01283","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally positioned between Pegivirus C and CRY2, linked by a downregulation event from the virus and a bi... | |
medium_hidden_intermediate_01284 | In a study of rhabdomyosarcoma cells (GSE103308), a gene is identified as being downregulated by Enterovirus A and associated with obesity disorder. This specific gene exhibits a log2 fold change of -1.357 and an adjusted p-value of 0.001456. Which protein is encoded by this gene? | Di-N-acetylchitobiase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01284","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), a gene is identified as being downregulated by Enterovirus A and associate... | |
medium_hidden_intermediate_01285 | Two genes are upregulated by Measles morbillivirus and both enable DNA-binding transcription repressor activity, RNA polymerase II-specific. One of these genes exhibits a log2 fold change of 1.449 and an adjusted p-value of 0.002322 in response to the virus. Which disease is associated with genomic alterations in this ... | endometrial carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01285","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Measles morbillivirus and both enable DNA-binding transcription repressor activity, RNA polymer... | |
medium_hidden_intermediate_01286 | Two genes are downregulated by Enterovirus A and enriched in neutrophils. One of these genes exhibits a log2 fold change of -1.669 and an adjusted p-value of 0.002998 in rhabdomyosarcoma cells. Which cellular component is the location of this specific gene? | extracellular region | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01286","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Enterovirus A and enriched in neutrophils. One of these genes exhibits a log2 fold change of ... | |
medium_hidden_intermediate_01287 | Zika virus downregulates a gene that is involved in DNA repair. In a study of glioma stem cells (GSE114907), one such gene exhibits a log2 fold change of approximately -2.405 and an adjusted p-value of 0.03326. Which cellular component is this gene located in? | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01287","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in DNA repair. In a study of glioma stem cells (GSE114907), one such gene e... | |
medium_hidden_intermediate_01293 | Two genes are each downregulated by Human immunodeficiency virus 1 and associated with lung carcinoma. One of these genes exhibits a log2 fold change of -1.595 and an adjusted p-value of 0.01341 in macrophages (study GSE108897). Which biological process is the gene matching these expression statistics involved in? | G protein-coupled receptor signaling pathway | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01293","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each downregulated by Human immunodeficiency virus 1 and associated with lung carcinoma. One of these genes ex... | |
medium_hidden_intermediate_01294 | In a study of sclera cells (GSE164073), Severe acute respiratory syndrome-related coronavirus was found to upregulate a specific gene, which in turn interacts with RAB7A. This gene exhibited a log2 fold change of 1.772 and an adjusted p-value of 0.002988. Which biological process is this gene involved in? | post-Golgi vesicle-mediated transport | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01294","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of sclera cells (GSE164073), Severe acute respiratory syndrome-related coronavirus was found to upregulate a spec... | |
medium_hidden_intermediate_01296 | Human alphaherpesvirus 1 is known to downregulate certain genes that are associated with colon carcinoma. One such gene exhibits a log2 fold change of -1.105 and an adjusted p-value of 0.009448 in a monocytic leukemia cell line study (GSE114966). Which protein is encoded by this specific gene? | UL16-binding protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01296","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 is known to downregulate certain genes that are associated with colon carcinoma. One such gene exhi... | |
medium_hidden_intermediate_01299 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a gene that subsequently binds to MCM6. One such gene exhibits a log2 fold change of 2.325 and an adjusted p-value of 0.001122. Which protein is encoded by this specific gene? | Cyclin-dependent kinase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01299","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a gene that subsequently binds to MC... | |
medium_hidden_intermediate_01300 | Human immunodeficiency virus 1 downregulates a gene that enables protein kinase binding. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of -2.051 and an adjusted p-value of 0.01235. Which protein is encoded by this gene? | TOM1-like protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01300","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that enables protein kinase binding. In a study of macrophages (GSE10889... | |
medium_hidden_intermediate_01301 | Human betaherpesvirus 5 upregulates a gene that interacts with PTPN11. Experimental data for one such gene reports a log2 fold change of approximately 1.93 and an adjusted p-value of 0.001364. Which protein is encoded by this gene? | Galectin-9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01301","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that interacts with PTPN11. Experimental data for one such gene reports a log2 fo... | |
medium_hidden_intermediate_01302 | Zika virus downregulates a gene that interacts with MOB1A. In glioma stem cells, one such gene exhibits a log2 fold change of -2.234 and an adjusted p-value of 0.01692. Which protein is encoded by this gene? | Serine/threonine-protein kinase 38-like | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01302","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with MOB1A. In glioma stem cells, one such gene exhibits a log2 fold change o... | |
medium_hidden_intermediate_01303 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a specific gene that participates in GPCR downstream signalling. This gene exhibited a log2 fold change of 8.719 and an adjusted p-value of 0.01104. What molecular function is enabled by this gene? | chemokine activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01303","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a specific gene tha... | |
medium_hidden_intermediate_01304 | In a study of choroid plexus epithelium (GSE157852), a gene is identified as being downregulated by Severe acute respiratory syndrome-related coronavirus and serving as a biomarker for bipolar disorder. This specific gene exhibits a log2 fold change of approximately -1.565 and an adjusted p-value of 0.04831. Which prot... | Proenkephalin-A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01304","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), a gene is identified as being downregulated by Severe acute respiratory... | |
medium_hidden_intermediate_01305 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated by the virus and its product binds to CTNNA1. Evidence for this gene reports a log2 fold change of 1.697 and an adjusted p-value of 0.04939. Which protein is encoded by this gene? | Cadherin EGF LAG seven-pass G-type receptor 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01305","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated by the virus a... | |
medium_hidden_intermediate_01306 | A gene serves as a marker for endothelial cells and is enriched in eosinophils. Evidence for one such gene reports a mean expression of 99.66 TPM, a z-score of 1.71, and a fold enrichment of 2.65. Which disease is associated with that gene? | myeloid leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01306","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for endothelial cells and is enriched in eosinophils. Evidence for one such gene reports a mean ex... | |
medium_hidden_intermediate_01307 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of a specific gene, which in turn binds to TAF10. This gene exhibits a log2 fold change of approximately 1.15 and an adjusted p-value of approximately 0.0088. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01307","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of a specific gene, whic... | |
medium_hidden_intermediate_01308 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is located in the axoneme. Evidence for this gene reports a log2 fold change of -1.149 and an adjusted p-value of 0.0004051. Which cell type is this gene enriched in? | non-classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01308","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is located in the axoneme. Evidence for... | |
medium_hidden_intermediate_01309 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and subsequently interacts with SP1. Experimental data for this gene reports a log2 fold change of approximately 3.17 and an adjusted p-value of approximately 0.00025. Which protein is encoded by this gene? | CCAAT/enhancer-binding protein beta | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01309","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and subsequent... | |
medium_hidden_intermediate_01310 | Measles morbillivirus downregulates a gene that participates in the Generic Transcription Pathway. Evidence for this gene reports a log2 fold change of -1.558 and an adjusted p-value of 1.389e-05. Which cell type is this gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01310","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus downregulates a gene that participates in the Generic Transcription Pathway. Evidence for this gene re... | |
medium_hidden_intermediate_01312 | Zika virus downregulates a specific gene that participates in signaling by BRAF and RAF1 fusions. Experimental data from glioma stem cells (study GSE114907) indicates this gene has a log2 fold change of approximately -2.77 and an adjusted p-value of 0.0043. In which cellular component is this gene located? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01312","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in signaling by BRAF and RAF1 fusions. Experimental data from gli... | |
medium_hidden_intermediate_01314 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the downregulation of certain genes that enable phosphatidylinositol-3,4-bisphosphate binding. One such gene exhibits a log2 fold change of approximately -3.04 and an adjusted p-value of 0.0036. Which protein is encoded by th... | SEC14 domain and spectrin repeat-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01314","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the downregulation of certain... | |
medium_hidden_intermediate_01319 | In a study of cervical adenocarcinoma cell lines (GSE11238), a specific gene is upregulated by Vaccinia virus and binds to SH3KBP1. This gene exhibits a log2 fold change of approximately 3.31 and an adjusted p-value of 0.00076. Which protein is encoded by this gene? | Immunoglobulin kappa variable 1-17 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01319","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a specific gene is upregulated by Vaccinia virus and binds to S... | |
medium_hidden_intermediate_01322 | Pegivirus C is reported to downregulate a gene that is located in the site of double-strand break. Evidence for this specific gene in peripheral blood mononuclear cells (study GSE131504) shows a log2 fold change of approximately -1.50 and an adjusted p-value of approximately 0.00031. Which protein is encoded by this ge... | Non-homologous end joining factor IFFO1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01322","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is located in the site of double-strand break. Evidence for this specifi... | |
medium_hidden_intermediate_01323 | Two genes are structurally positioned between Severe acute respiratory syndrome-related coronavirus and YWHAG, linked by downregulation from the virus and interaction with YWHAG. One of these genes exhibits a log2 fold change of approximately -1.56 and an adjusted p-value of 0.048 in a specific study. Which disease is ... | invasive breast carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01323","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally positioned between Severe acute respiratory syndrome-related coronavirus and YWHAG, linked by dow... | |
medium_hidden_intermediate_01324 | Pegivirus C downregulates a specific gene that is involved in the positive regulation of transcription by RNA polymerase II. Experimental data for this gene in peripheral blood mononuclear cells (study GSE131504) reports a log2 fold change of approximately -2.37 and an adjusted p-value of approximately 0.0016. Which ce... | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01324","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a specific gene that is involved in the positive regulation of transcription by RNA polymerase II.... | |
medium_hidden_intermediate_01326 | Hepacivirus C infection is associated with the upregulation of a specific gene, which is subsequently found to be enriched in Gamma delta (γδ) T cells. Experimental data for this gene reports a log2 fold change of approximately 1.82 and an adjusted p-value of approximately 0.000108. Which protein is encoded by this gen... | Septin-4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01326","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C infection is associated with the upregulation of a specific gene, which is subsequently found to be enriched i... | |
medium_hidden_intermediate_01327 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that subsequently interacts with RHOA. One such gene exhibits a log2 fold change of approximately 1.088 and an adjusted p-value of 0.004229. Which protein is encoded by this specific gene? | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01327","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that subsequently interacts with RH... | |
medium_hidden_intermediate_01328 | Zika virus downregulates a gene that binds to SNAPC1. Experimental data for this gene in glioma stem cells (study GSE114907) shows a log2 fold change of -2.288 and an adjusted p-value of 0.005824. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01328","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that binds to SNAPC1. Experimental data for this gene in glioma stem cells (study GSE114907)... | |
medium_hidden_intermediate_01329 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific gene, which in turn participates in Viral Infection Pathways. This gene exhibited a log2 fold change of -1.772 and an adjusted p-value of 0.01572. Which protein is encoded by this gene? | Rho-associated protein kinase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01329","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific g... | |
medium_hidden_intermediate_01330 | CRYAA interacts with a specific crystallin protein that enables protein binding. Evidence regarding this protein indicates that Chloramphenicol acetyltransferase activity assays revealed interactions between alphaA- (or alphaB-) and betaB2- or gammaC-crystallins, with an intensity one-third that of alphaA-alphaB intera... | cerulean cataract | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01330","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"CRYAA interacts with a specific crystallin protein that enables protein binding. Evidence regarding this protein indicates t... | |
medium_hidden_intermediate_01331 | Two genes are linked to Measles morbillivirus via upregulation and to obesity disorder via biomarker association. One of these genes has an associated study reporting a log2 fold change of approximately 1.799 and an adjusted p-value of approximately 0.00039. Which protein is encoded by this specific gene? | Forkhead box protein O3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01331","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Measles morbillivirus via upregulation and to obesity disorder via biomarker association. One of the... | |
medium_hidden_intermediate_01332 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables DNA-binding transcription activator activity, RNA polymerase II-specific. Experimental evidence for this gene reports a log2 fold change of approximately 1.28 and an adjusted p-value of approximately 0.0073. Which cellular compon... | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01332","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables DNA-binding transcription activat... | |
medium_hidden_intermediate_01334 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a gene that enables N-acetyltransferase activity. One such gene exhibited a log2 fold change of approximately 1.20 and an adjusted p-value of 0.0371. Which protein is encoded by this specific gene? | N-acetyltransferase ESCO1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01334","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a gene that enables N-acet... | |
medium_hidden_intermediate_01335 | In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and serves as a biomarker for disease. Evidence for this gene reports a log2 fold change of 1.187 and an adjusted p-value of 0.004815. Which protein is encoded by this gene? | Fatty acyl-CoA reductase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01335","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and serves as a biomarker for dis... | |
medium_hidden_intermediate_01336 | In a study of umbilical vein endothelial cells (GSE119608), a gene located in the apical plasma membrane was found to be downregulated by Human gammaherpesvirus 8. This specific gene exhibited a log2 fold change of -1.841 and an adjusted p-value of 0.01117. Which protein is encoded by this gene? | Sodium-dependent phosphate transport protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01336","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of umbilical vein endothelial cells (GSE119608), a gene located in the apical plasma membrane was found to be dow... | |
medium_hidden_intermediate_01337 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Downstream TCR signaling. Experimental evidence for this gene reports a log2 fold change of -1.142 and an adjusted p-value of 0.004331. Which protein is encoded by this gene? | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01337","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Downstream TCR signalin... | |
medium_hidden_intermediate_01339 | Pegivirus C downregulates a specific gene, which in turn interacts with UBE2D2. Experimental data for this intermediate gene in peripheral blood mononuclear cells (study GSE131504) shows a log2 fold change of approximately -2.03 and an adjusted p-value of 0.000148. Which cellular component is this intermediate gene loc... | CCR4-NOT complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01339","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a specific gene, which in turn interacts with UBE2D2. Experimental data for this intermediate gene... | |
medium_hidden_intermediate_01342 | Human betaherpesvirus 5 upregulates a gene that is enriched in intermediate monocytes. Evidence for this gene in foreskin fibroblast cell lines (study GSE132081) reports a log2 fold change of 1.062 and an adjusted p-value of 0.0002238. Which protein is encoded by this gene? | Single-pass membrane and coiled-coil domain-containing protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01342","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that is enriched in intermediate monocytes. Evidence for this gene in foreskin fi... | |
medium_hidden_intermediate_01344 | Zika virus upregulates a gene that participates in the Immune System. Experimental data for this gene shows a log2 fold change of approximately 1.258 and an adjusted p-value of 0.001723. Which protein is encoded by this gene? | F-box/WD repeat-containing protein 8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01344","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that participates in the Immune System. Experimental data for this gene shows a log2 fold chan... | |
medium_hidden_intermediate_01345 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in the formation of the cornified envelope. One of these genes exhibits a log2 fold change of -2.485 and an adjusted p-value of 0.003474 in a specific study. Which cellular component is the location of this specific gen... | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01345","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in the formation of the... | |
medium_hidden_intermediate_01347 | Measles morbillivirus upregulates a gene that interacts with STRIP1. One such gene exhibits a log2 fold change of 2.015 and an adjusted p-value of 0.01984. Which protein is encoded by this gene? | Sarcolemmal membrane-associated protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01347","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that interacts with STRIP1. One such gene exhibits a log2 fold change of 2.015 and ... | |
medium_hidden_intermediate_01348 | Human immunodeficiency virus 1 upregulates a gene that participates in the response to elevated platelet cytosolic Ca2+. Evidence for this gene in macrophages (study GSE108897) reports a log2 fold change of approximately 1.037 and an adjusted p-value of 0.03055. Which protein is encoded by this gene? | LHFPL tetraspan subfamily member 2 protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01348","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in the response to elevated platelet cytosolic Ca2+. Evi... | |
medium_hidden_intermediate_01349 | Zika virus downregulates a gene that participates in peptide hormone metabolism. Evidence for this gene reports a log2 fold change of -1.518 and an adjusted p-value of 0.02715. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01349","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in peptide hormone metabolism. Evidence for this gene reports a log2 fold ... | |
medium_hidden_intermediate_01350 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection was found to downregulate a gene that participates in extracellular matrix organization. One such gene exhibited a log2 fold change of approximately -1.93 and an adjusted p-value of 0.0192. Which protein is encoded by this specific ge... | Lysyl oxidase homolog 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01350","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection was found to downregulate a gene that ... | |
medium_hidden_intermediate_01352 | Human alphaherpesvirus 3 is reported to upregulate multiple genes that are located in the membrane. One such gene exhibits a log2 fold change of 1.254 and an adjusted p-value of 4.982e-06 in a melanoma cell line study (GSE136586). Which protein is encoded by this specific gene? | Cytosolic phospholipase A2 gamma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01352","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 is reported to upregulate multiple genes that are located in the membrane. One such gene exhibits a... | |
medium_hidden_intermediate_01353 | Measles morbillivirus upregulates a gene that interacts with TRIM21. One such gene exhibits a log2 fold change of 1.603 and an adjusted p-value of 1.6e-05. Which protein is encoded by this gene? | PHD finger protein 19 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01353","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that interacts with TRIM21. One such gene exhibits a log2 fold change of 1.603 and ... | |
medium_hidden_intermediate_01354 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes that subsequently bind to RPS28. One such gene exhibited a log2 fold change of approximately 1.153 and an adjusted p-value of 1.052e-07. Which protein is encoded by this specific gene? | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01354","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes ... | |
medium_hidden_intermediate_01357 | Human immunodeficiency virus 1 upregulates a gene that is involved in chemical synaptic transmission. Evidence for this gene reports a log2 fold change of 8.205 and an adjusted p-value of 2.929e-05. Which disease is associated with this gene as a biomarker? | coronary artery disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01357","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is involved in chemical synaptic transmission. Evidence for this gene... | |
medium_hidden_intermediate_01358 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the cellular response to UV. Evidence for this gene reports a log2 fold change of -1.084 and an adjusted p-value of 0.0238. Which protein is encoded by this gene? | TP53-regulated inhibitor of apoptosis 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01358","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the cellular response to... | |
medium_hidden_intermediate_01361 | Enterovirus A upregulates a specific gene that is involved in the positive regulation of transcription by RNA polymerase II. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) reports a log2 fold change of approximately 1.114 and an adjusted p-value of 0.001109. Which disease is associated with... | classic familial adenomatous polyposis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01361","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A upregulates a specific gene that is involved in the positive regulation of transcription by RNA polymerase II.... | |
medium_hidden_intermediate_01362 | Hepacivirus C downregulates a gene that participates in the Immune System. Evidence for one such gene reports a log2 fold change of -1.406 and an adjusted p-value of 0.005799. Which molecular function is enabled by that gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01362","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a gene that participates in the Immune System. Evidence for one such gene reports a log2 fold ch... | |
medium_hidden_intermediate_01363 | Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to the Golgi membrane via a 'located in' relationship. One of these genes has an associated expression profile showing a log2 fold change of -1.469 and an adjusted p-value of 0.005464. Which cell type is enriched ... | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01363","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to the Golgi memb... | |
medium_hidden_intermediate_01364 | Zika virus downregulates a gene that interacts with CLPP. In glioma stem cells, one such gene exhibits a log2 fold change of -1.130 and an adjusted p-value of 0.04645. What molecular function is enabled by this gene? | trimethyllysine dioxygenase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01364","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with CLPP. In glioma stem cells, one such gene exhibits a log2 fold change of... | |
medium_hidden_intermediate_01366 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and associated with benign neoplasm showed a log2 fold change of approximately 8.57 and an adjusted p-value of 0.000687. Which protein is encoded by this gene? | C-C motif chemokine 22 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01366","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and associated with benign... | |
medium_hidden_intermediate_01368 | A gene is upregulated by Primate bocaparvovirus 1 and enables identical protein binding. Experimental evidence for this gene reports a log2 fold change of 1.632 and an adjusted p-value of 0.03496. Which gene interacts with the entity identified by these statistics? | MAP4K4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01368","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and enables identical protein binding. Experimental evidence for this gene... | |
medium_hidden_intermediate_01369 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and located in the lysosome. Evidence for this gene reports a log2 fold change of 1.739 and an adjusted p-value of 0.04532. Which cell type is this gene enriched in? | intermediate monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01369","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and located in the lysosome. Evidence for thi... | |
medium_hidden_intermediate_01371 | Rhinovirus A upregulates a specific gene that is involved in the negative regulation of transcription by RNA polymerase II. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of 1.423 and an adjusted p-value of 0.01442. Which disease is associated with this gene... | plasma cell myeloma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01371","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A upregulates a specific gene that is involved in the negative regulation of transcription by RNA polymerase II. ... | |
medium_hidden_intermediate_01375 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the Toll Like Receptor TLR6:TLR2 Cascade. One of these genes exhibits a log2 fold change of approximately 2.597 and an adjusted p-value of 0.005074 in lung tissue. Which cell type is enriched for this specific gene? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01375","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the Toll Like Receptor... | |
medium_hidden_intermediate_01376 | Zika virus downregulates a gene that is involved in interstrand cross-link repair. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of approximately -3.29 and an adjusted p-value of 0.01285. Which protein is encoded by this specific gene? | Exonuclease V | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01376","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in interstrand cross-link repair. In a study of glioma stem cells (GSE11490... | |
medium_hidden_intermediate_01377 | Cardiovirus A downregulates a gene that is located in a protein-containing complex. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of -1.183 and an adjusted p-value of 0.01358. Which disease is associated with this gene as a biomarker? | diabetic kidney disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01377","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A downregulates a gene that is located in a protein-containing complex. Experimental data for this gene in a cer... | |
medium_hidden_intermediate_01378 | Two genes are structurally linked to Vaccinia virus via downregulation and to Signaling by Rho GTPases via participation. One of these genes exhibits a log2 fold change of -1.485 and an adjusted p-value of 0.0006996 in cervical adenocarcinoma cell lines. Which cell type is enriched for this specific gene? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01378","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Vaccinia virus via downregulation and to Signaling by Rho GTPases via participation. On... | |
medium_hidden_intermediate_01379 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the positive regulation of DNA-templated transcription. Experimental data for this gene reports a log2 fold change of -1.596 and an adjusted p-value of 0.02256. In which cell type is this gene enriched? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01379","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the positive regulation ... | |
medium_hidden_intermediate_01380 | Two distinct cell types are structurally linked to the IgD immunoglobulin complex via the relation 'absent from cell plasma membrane' and to MMP12 via the relation 'has marker'. One of these entities is described as a B cell with the phenotype surface IgM-positive and surface IgD-negative, which has not undergone immun... | B cell, CD19-positive | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01380","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct cell types are structurally linked to the IgD immunoglobulin complex via the relation 'absent from cell plasma ... | |
medium_hidden_intermediate_01381 | Two genes are structurally linked from Enterovirus A to acute lymphoblastic leukemia via a downregulation relationship followed by an association. One of these genes has a reported log2 fold change of -1.260 and an adjusted p-value of 0.007426 in rhabdomyosarcoma cells. Which disease is connected to this specific gene ... | asthma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01381","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Enterovirus A to acute lymphoblastic leukemia via a downregulation relationship follo... |
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