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medium_hidden_intermediate_01384 | Two genes are structurally linked from Severe acute respiratory syndrome-related coronavirus via a downregulation relationship and onward to squamous cell carcinoma via an association. One of these genes is reported in a study with a log2 fold change of -2.539 and an adjusted p-value of 1.055e-06. Which protein is enco... | Elafin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01384","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Severe acute respiratory syndrome-related coronavirus via a downregulation relationsh... | |
medium_hidden_intermediate_01386 | A gene serves as a marker for SLC16A7+ cells and is enriched in intermediate monocytes. Evidence for one such gene reports a mean expression of 4.09 TPM, a z-score of 1.66, and a fold enrichment of 2.86. Which biological process is this gene involved in? | regulation of cell cycle | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01386","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for SLC16A7+ cells and is enriched in intermediate monocytes. Evidence for one such gene reports a... | |
medium_hidden_intermediate_01388 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with ARF6. One of these genes exhibits a log2 fold change of -1.569 and an adjusted p-value of 0.04767 in a specific study. Which protein is encoded by this gene? | Stomatin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01388","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with ARF6. One of these ge... | |
medium_hidden_intermediate_01389 | Two genes are linked to Human betaherpesvirus 5 via upregulation and to alcohol abuse via biomarker association. One of these genes exhibits a log2 fold change of 1.267 and an adjusted p-value of 0.0009367 in foreskin fibroblast cell lines. What molecular function is enabled by this specific gene? | GABA-A receptor activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01389","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Human betaherpesvirus 5 via upregulation and to alcohol abuse via biomarker association. One of thes... | |
medium_hidden_intermediate_01391 | Pegivirus C is reported to downregulate a gene that subsequently interacts with TTC4. Experimental data from a study on peripheral blood mononuclear cells (GSE131504) indicates that this intermediate gene has a log2 fold change of -1.792 and an adjusted p-value of 4.662e-05. Which protein is encoded by this specific ge... | Vacuolar protein sorting-associated protein 35 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01391","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that subsequently interacts with TTC4. Experimental data from a study on peri... | |
medium_hidden_intermediate_01392 | Human betaherpesvirus 5 is reported to downregulate a gene that participates in lipid metabolism. In a study of foreskin fibroblast cell lines (GSE111036), one such gene exhibits a log2 fold change of -1.374 and an adjusted p-value of 0.0288. Which biological process is this specific gene involved in? | ketone body metabolic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01392","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that participates in lipid metabolism. In a study of foreskin fib... | |
medium_hidden_intermediate_01393 | Zika virus downregulates a specific gene that subsequently binds to RPS14. Experimental data for this gene reports a log2 fold change of -1.041 and an adjusted p-value of 0.02555. In which cell type is this gene enriched? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01393","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that subsequently binds to RPS14. Experimental data for this gene reports a log2 fo... | |
medium_hidden_intermediate_01394 | Pegivirus C is reported to downregulate a specific gene that participates in the G2/M transition. Evidence for this gene in peripheral blood mononuclear cells shows a log2 fold change of -1.193 and an adjusted p-value of 0.01068. In which cell type is this gene enriched? | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01394","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene that participates in the G2/M transition. Evidence for this gene in ... | |
medium_hidden_intermediate_01395 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the regulation of mRNA splicing via the spliceosome. Evidence for one such gene reports a log2 fold change of 1.104 and an adjusted p-value of 0.004887. Which protein is encoded by that gene? | Cyclin-L1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01395","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the regulation of mRNA splicing... | |
medium_hidden_intermediate_01396 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in G alpha (q) signalling events. One of these genes exhibits a log2 fold change of approximately 4.94 and an adjusted p-value of 0.046 in sclera tissue. Which disease is associated with this specific gene? | acidosis disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01396","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in G alpha (q) signalling... | |
medium_hidden_intermediate_01397 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that is located in the endoplasmic reticulum membrane. One such gene exhibits a log2 fold change of 1.429 and an adjusted p-value of 9.879e-05. Which molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01397","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that is located in the endoplasmic ... | |
medium_hidden_intermediate_01398 | Human betaherpesvirus 5 upregulates a gene that is involved in the transforming growth factor beta receptor signaling pathway. Evidence for this gene in foreskin fibroblast cell lines (study GSE132081) reports a log2 fold change of approximately 1.333 and an adjusted p-value of 0.0002767. Which disease is associated wi... | carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01398","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that is involved in the transforming growth factor beta receptor signaling pathwa... | |
medium_hidden_intermediate_01401 | Enterovirus A upregulates a gene that is located in the P-body. In a study of rhabdomyosarcoma cells (GSE103308), this gene exhibited a log2 fold change of 1.063 and an adjusted p-value of 0.01267. Which protein is encoded by this gene? | Trinucleotide repeat-containing gene 6A protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01401","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A upregulates a gene that is located in the P-body. In a study of rhabdomyosarcoma cells (GSE103308), this gene ... | |
medium_hidden_intermediate_01402 | Zika virus downregulates a specific gene that is also associated with gastric cancer. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -3.448 and an adjusted p-value of 0.003194. Which disease is linked to this gene as a biomarker? | pancreatic adenocarcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01402","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is also associated with gastric cancer. Experimental data for this gene in gli... | |
medium_hidden_intermediate_01404 | A gene is upregulated by Vaccinia virus and participates in PI Metabolism. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of 1.131 and an adjusted p-value of 0.001527. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01404","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Vaccinia virus and participates in PI Metabolism. Experimental data for this gene in a cervical ade... | |
medium_hidden_intermediate_01405 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and both enable small GTPase binding. One of these genes was reported in a study of bronchial epithelial cells with a log2 fold change of approximately -1.97 and an adjusted p-value of 0.0246. Which gene interacts with the gene identif... | RAB11A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01405","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and both enable small GTPase binding. O... | |
medium_hidden_intermediate_01407 | Pegivirus C downregulates a gene that subsequently interacts with CTNNB1. Experimental data for this intermediate gene in peripheral blood mononuclear cells (study GSE131504) reports a log2 fold change of approximately -1.17 and an adjusted p-value of 0.002284. Which protein is encoded by this gene? | Transcriptional regulator Kaiso | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01407","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that subsequently interacts with CTNNB1. Experimental data for this intermediate gene in pe... | |
medium_hidden_intermediate_01410 | Two genes serve as markers for germ cells and are also associated with clear cell renal carcinoma as biomarkers. One of these genes is targeted by miR-10b, which exerts a tumor-suppressive effect on clear cell renal carcinoma in vitro. Which biological process is the gene targeted by miR-10b involved in? | angiogenesis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01410","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes serve as markers for germ cells and are also associated with clear cell renal carcinoma as biomarkers. One of thes... | |
medium_hidden_intermediate_01411 | Zika virus downregulates a specific gene that participates in PIWI-interacting RNA (piRNA) biogenesis. In glioma stem cells, this gene exhibits a log2 fold change of approximately -1.21 and an adjusted p-value of 0.0475. Which protein is encoded by this gene? | Small RNA 2'-O-methyltransferase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01411","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in PIWI-interacting RNA (piRNA) biogenesis. In glioma stem cells,... | |
medium_hidden_intermediate_01413 | Human immunodeficiency virus 1 downregulates a gene that is involved in the positive regulation of endothelial cell proliferation. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately -3.61 and an adjusted p-value of approximately 0.00046. Which protein is encoded by this gene? | Angiopoietin-1 receptor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01413","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is involved in the positive regulation of endothelial cell prolifer... | |
medium_hidden_intermediate_01414 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is downregulated by the virus and participates in the cellular response to chemical stress. Evidence for this gene reports a log2 fold change of -1.702 and an adjusted p-value of 0.008429. Which protein is encoded by... | Glutathione peroxidase 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01414","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is downregulated by ... | |
medium_hidden_intermediate_01415 | Hepacivirus C upregulates a gene that is involved in the immune response. Experimental data for this gene shows a log2 fold change of approximately 4.11 and an adjusted p-value of 3.938e-05. Which protein is encoded by this gene? | Neutrophil defensin 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01415","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in the immune response. Experimental data for this gene shows a log2 fold ... | |
medium_hidden_intermediate_01416 | In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and participates in the RHOB GTPase cycle. This specific gene exhibits a log2 fold change of -2.537 and an adjusted p-value of 0.003535. Which protein is encoded by this gene? | StAR-related lipid transfer protein 13 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01416","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and part... | |
medium_hidden_intermediate_01418 | Zika virus downregulates a gene that is located in the nuclear envelope. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -3.217 and an adjusted p-value of 0.003988. Which protein is encoded by this gene? | Transmembrane protein 201 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01418","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in the nuclear envelope. In a study of glioma stem cells (GSE114907), one su... | |
medium_hidden_intermediate_01419 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that binds to PTPRF. Experimental data for one such gene reports a log2 fold change of -1.247 and an adjusted p-value of 8.172e-05. Which protein is encoded by that gene? | Interleukin-1 receptor accessory protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01419","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that binds to PTPRF. Experimental data for one su... | |
medium_hidden_intermediate_01420 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in Vesicle-mediated transport. Evidence for this specific gene reports a log2 fold change of 1.154 and an adjusted p-value of 0.009924. Which biological process is this gene involved in? | positive regulation of membrane protein ectodomain proteolysis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01420","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in Vesicle-mediat... | |
medium_hidden_intermediate_01421 | Two genes are each upregulated by Severe acute respiratory syndrome-related coronavirus and associated with common cold. One of these genes exhibits a log2 fold change of approximately 2.28 and an adjusted p-value of 0.0091 in cardiomyocyte cell lines (study GSE151879). Which disease is linked to this specific gene thr... | hepatocellular carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01421","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each upregulated by Severe acute respiratory syndrome-related coronavirus and associated with common cold. One... | |
medium_hidden_intermediate_01422 | Two genes are each downregulated by Severe acute respiratory syndrome-related coronavirus and associated with lung carcinoma. One of these genes exhibits a log2 fold change of -1.198 and an adjusted p-value of 0.001009 in a specific study. Which gene interacts with the gene identified by these statistical values? | SGCG | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01422","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each downregulated by Severe acute respiratory syndrome-related coronavirus and associated with lung carcinoma... | |
medium_hidden_intermediate_01423 | Human immunodeficiency virus 1 downregulates a gene that enables sequence-specific double-stranded DNA binding. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of approximately -3.46 and an adjusted p-value of approximately 0.0104. Which protein interacts with this specific gene produc... | TLE1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01423","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that enables sequence-specific double-stranded DNA binding. In a study o... | |
medium_hidden_intermediate_01424 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate genes involved in fatty acid metabolism. One such gene exhibited a log2 fold change of approximately 2.48 and an adjusted p-value of 2.10e-08. Which protein is encoded by this specific gene? | Enoyl-[acyl-carrier-protein] reductase, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01424","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate genes involved... | |
medium_hidden_intermediate_01426 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to downregulate certain genes involved in glycosaminoglycan metabolism. One such gene exhibited a log2 fold change of -1.607 and an adjusted p-value of 5.421e-05. Which protein is encoded by this specific gene? | 2-phosphoxylose phosphatase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01426","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to downregulate certain genes involved i... | |
medium_hidden_intermediate_01427 | A gene is upregulated by Primate bocaparvovirus 1 and enables DNA binding. Experimental evidence for this gene reports a log2 fold change of 1.069 and an adjusted p-value of 0.02289. Which disease is associated with this gene? | lung neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01427","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and enables DNA binding. Experimental evidence for this gene reports a log... | |
medium_hidden_intermediate_01428 | Identify the gene that serves as a marker for astrocytes and is involved in the apoptotic process. This specific gene is transcriptionally activated by p53 and is believed to play a role in DNA damage response and reactive oxygen species-induced apoptosis. Which disease is associated with this gene through genomic alte... | urinary bladder carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01428","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Identify the gene that serves as a marker for astrocytes and is involved in the apoptotic process. This specific gene is tra... | |
medium_hidden_intermediate_01429 | Two genes are upregulated by Human alphaherpesvirus 1 and are enriched in non-classical monocytes. One of these genes has a reported log2 fold change of 1.817 and an adjusted p-value of 0.004662. Which protein is encoded by this specific gene? | Creatine kinase B-type | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01429","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human alphaherpesvirus 1 and are enriched in non-classical monocytes. One of these genes has a ... | |
medium_hidden_intermediate_01430 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that subsequently interacts with YWHAZ. One such gene exhibits a log2 fold change of 1.306 and an adjusted p-value of 0.005644. Which protein is encoded by this specific gene? | Protein FAM117B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01430","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that subsequently interacts with YW... | |
medium_hidden_intermediate_01432 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with peritonitis. One of these genes was reported in a study of bronchial epithelial cells (GSE147507) with a log2 fold change of 2.252 and an adjusted p-value of 0.0003958. Which protein is encoded by this specific ge... | Neutrophil gelatinase-associated lipocalin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01432","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with peritonitis. One ... | |
medium_hidden_intermediate_01433 | Zaire ebolavirus upregulates a gene that enables calcium ion binding. In a study of retinal pigment epithelium cells (GSE100839), one such gene showed a log2 fold change of 1.924 and an adjusted p-value of 0.01095. Which disease is associated with this gene as a biomarker? | schizophrenia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01433","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus upregulates a gene that enables calcium ion binding. In a study of retinal pigment epithelium cells (GSE100... | |
medium_hidden_intermediate_01434 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Cell junction organization. Experimental data for this gene reports a log2 fold change of -1.384 and an adjusted p-value of 0.03944. Which protein is encoded by this gene? | Twist-related protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01434","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Cell junction organizat... | |
medium_hidden_intermediate_01436 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in the process where SUMO E3 ligases SUMOylate target proteins. Evidence for this specific gene reports a log2 fold change of -1.300 and an adjusted p-value of 5.723e-07. Which protein is encoded by this gene? | E3 SUMO-protein ligase ZBED1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01436","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in the process where SUMO E3 li... | |
medium_hidden_intermediate_01438 | Zika virus downregulates a gene that interacts with RNF185. In glioma stem cells, one such gene exhibits a log2 fold change of approximately -1.29 and an adjusted p-value of 0.0294. Which protein is encoded by this gene? | Transmembrane and ubiquitin-like domain-containing protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01438","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with RNF185. In glioma stem cells, one such gene exhibits a log2 fold change ... | |
medium_hidden_intermediate_01439 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a gene involved in the regulation of macroautophagy. This specific gene exhibited a log2 fold change of 3.061 and an adjusted p-value of 0.002051. Which protein is encoded by this gene? | V-type proton ATPase subunit e 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01439","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a gene involved in the reg... | |
medium_hidden_intermediate_01442 | Vaccinia virus upregulates a gene that serves as a biomarker for lung cancer. In a study of cervical adenocarcinoma cell lines (GSE11238), one such gene exhibits a log2 fold change of approximately 1.533 and an adjusted p-value of 1.658e-11. Which protein is encoded by this specific gene? | Destrin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01442","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a gene that serves as a biomarker for lung cancer. In a study of cervical adenocarcinoma cell lin... | |
medium_hidden_intermediate_01446 | Two genes are downregulated by Cardiovirus A and located in the cytoplasmic vesicle. One of these genes exhibits a log2 fold change of -1.614 and an adjusted p-value of 0.01595 in cervical adenocarcinoma cell lines. Which cell type is enriched for this specific gene? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01446","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Cardiovirus A and located in the cytoplasmic vesicle. One of these genes exhibits a log2 fold... | |
medium_hidden_intermediate_01447 | Human mastadenovirus C upregulates a gene that enables protein binding. In a study of lung fibroblast cell lines (GSE120891), one such gene showed a log2 fold change of approximately 1.07 and an adjusted p-value of 0.038. Which protein is encoded by this specific gene? | Signal peptide peptidase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01447","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human mastadenovirus C upregulates a gene that enables protein binding. In a study of lung fibroblast cell lines (GSE120891)... | |
medium_hidden_intermediate_01449 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in Transcriptional Regulation by TP53. Evidence for one such gene reports a log2 fold change of -1.084 and an adjusted p-value of 0.0238. Which protein is encoded by that gene? | TP53-regulated inhibitor of apoptosis 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01449","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in Transcriptional Regulation b... | |
medium_hidden_intermediate_01450 | Rhinovirus A infection leads to the downregulation of certain genes, which in turn interact with STAT1. One such gene exhibits a log2 fold change of -1.310 and an adjusted p-value of 0.0008505 in cytotoxic T-lymphocytes. Which protein is encoded by this specific gene? | E3 ubiquitin-protein ligase DTX3L | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01450","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection leads to the downregulation of certain genes, which in turn interact with STAT1. One such gene exhibi... | |
medium_hidden_intermediate_01451 | Zika virus downregulates a specific gene, which in turn interacts with RPL31. Transcriptomic data from glioma stem cells (study GSE114907) indicates that this gene has a log2 fold change of approximately -2.51 and an adjusted p-value of 0.0066. Which protein is encoded by this gene? | Probable ATP-dependent RNA helicase DDX27 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01451","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with RPL31. Transcriptomic data from glioma stem cells (st... | |
medium_hidden_intermediate_01452 | Measles morbillivirus upregulates a gene that participates in the RAF/MAP kinase cascade. Experimental data for this gene shows a log2 fold change of approximately 1.26 and an adjusted p-value of 4.84e-05. Which biological process is this gene involved in? | small GTPase-mediated signal transduction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01452","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that participates in the RAF/MAP kinase cascade. Experimental data for this gene sh... | |
medium_hidden_intermediate_01453 | A protein interacts with CFTR and is located in the endoplasmic reticulum. Experimental evidence indicates that this protein co-immunoprecipitates and co-localizes with CAL and STX6, and its binding to CAL is enhanced by STX6, suggesting a synergistic interaction. Which gene encodes this protein? | E3 ubiquitin-protein ligase MARCHF2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01453","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A protein interacts with CFTR and is located in the endoplasmic reticulum. Experimental evidence indicates that this protein... | |
medium_hidden_intermediate_01455 | A gene is downregulated by Primate bocaparvovirus 1 and interacts with the SET protein. Experimental data for this gene in tracheobronchial epithelial cells shows a log2 fold change of approximately -1.206 and an adjusted p-value of 0.03159. Which protein is encoded by this gene? | Granzyme A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01455","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and interacts with the SET protein. Experimental data for this gene in t... | |
medium_hidden_intermediate_01456 | Zika virus downregulates a gene that participates in G2/M Checkpoints. In a study of glioma stem cells (GSE114907), one such gene showed a log2 fold change of -2.217 and an adjusted p-value of 0.02728. Which protein is encoded by this gene? | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01456","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in G2/M Checkpoints. In a study of glioma stem cells (GSE114907), one such... | |
medium_hidden_intermediate_01458 | Two genes are structurally linked to Cardiovirus A via a 'downregulates' relationship and to ATP binding via an 'enables' relationship. One of these genes has a reported log2 fold change of -1.862 and an adjusted p-value of 0.02754 in cervical adenocarcinoma cell lines (study GSE122967). Which disease is associated wit... | asthma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01458","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Cardiovirus A via a 'downregulates' relationship and to ATP binding via an 'enables' re... | |
medium_hidden_intermediate_01460 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to the regulation of lipid metabolism by PPARalpha via a participation relationship. One of these genes is associated with experimental data showing a log2 fold change of 2.026 and an adjusted... | GRHL3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01460","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship ... | |
medium_hidden_intermediate_01461 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which in turn interacts with RPA3. This gene exhibits a log2 fold change of approximately -1.31 and an adjusted p-value of 0.0116. Which protein is encoded by this gene? | ATP-dependent DNA/RNA helicase DHX36 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01461","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_01465 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with WDR20. Evidence for one such gene reports a log2 fold change of 1.951 and an adjusted p-value of 0.01028. Which protein is encoded by that gene? | PH domain leucine-rich repeat-containing protein phosphatase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01465","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with WDR20. Evidence for one such ge... | |
medium_hidden_intermediate_01466 | Human polyomavirus 1 upregulates a gene that is located in the endoplasmic reticulum membrane. Experimental data for this gene in renal epithelial cells shows a log2 fold change of 2.323 and an adjusted p-value of 1.38e-05. Which cell type is this gene enriched in? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01466","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human polyomavirus 1 upregulates a gene that is located in the endoplasmic reticulum membrane. Experimental data for this ge... | |
medium_hidden_intermediate_01468 | Human immunodeficiency virus 1 upregulates a gene that is enriched in intermediate monocytes. Evidence for this gene reports a log2 fold change of 5.177 and an adjusted p-value of 0.005031. Which protein is encoded by this gene? | Fibroleukin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01468","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is enriched in intermediate monocytes. Evidence for this gene reports... | |
medium_hidden_intermediate_01469 | Human betaherpesvirus 5 is associated with the upregulation of a gene that participates in tryptophan catabolism. Experimental data for this specific gene reports a log2 fold change of approximately 4.33 and an adjusted p-value of 0.0211. Which protein is encoded by this gene? | Indoleamine 2,3-dioxygenase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01469","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is associated with the upregulation of a gene that participates in tryptophan catabolism. Experiment... | |
medium_hidden_intermediate_01470 | Two genes are upregulated by Human immunodeficiency virus 1 and are associated with colon carcinoma. One of these genes exhibits a log2 fold change of approximately 1.71 and an adjusted p-value of approximately 0.0047 in macrophages (study GSE108897). Which disease is linked to this specific gene through genomic altera... | age-related macular degeneration | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01470","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and are associated with colon carcinoma. One of these genes exhi... | |
medium_hidden_intermediate_01471 | Human alphaherpesvirus 1 upregulates a gene that participates in mitochondrial protein degradation. Evidence for one such gene reports a log2 fold change of 1.414 and an adjusted p-value of 0.005251. Which protein is encoded by that gene? | D-beta-hydroxybutyrate dehydrogenase, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01471","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that participates in mitochondrial protein degradation. Evidence for one such ge... | |
medium_hidden_intermediate_01472 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and interacts with VPS29. This gene exhibits a log2 fold change of 1.424 and an adjusted p-value of 0.0004789. Which protein is encoded by this gene? | FK506-binding protein 15 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01472","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and interacts with VPS2... | |
medium_hidden_intermediate_01473 | Human immunodeficiency virus 1 downregulates a gene that is involved in the proteasome-mediated ubiquitin-dependent protein catabolic process. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately -1.133 and an adjusted p-value of 0.005961. Which cellular component is this gene ... | Cul3-RING ubiquitin ligase complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01473","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is involved in the proteasome-mediated ubiquitin-dependent protein ... | |
medium_hidden_intermediate_01474 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that is located in the focal adhesion. This specific gene exhibits a log2 fold change of approximately 2.52 and an adjusted p-value of 0.0158. Which protein does this gene interact with? | TRAF4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01474","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that is located in the focal adhesi... | |
medium_hidden_intermediate_01476 | A gene is downregulated by Primate bocaparvovirus 1 and is enriched in non-classical monocytes. Experimental evidence for this gene reports a log2 fold change of -1.505 and an adjusted p-value of 0.0294. Which protein is encoded by this gene? | Coiled-coil domain-containing protein 24 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01476","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and is enriched in non-classical monocytes. Experimental evidence for th... | |
medium_hidden_intermediate_01477 | Zika virus downregulates a specific gene that enables kinase binding. In glioma stem cells, this gene exhibits a log2 fold change of approximately -2.26 and an adjusted p-value of 0.0133. Which disease is associated with this gene? | hypertrophic cardiomyopathy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01477","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that enables kinase binding. In glioma stem cells, this gene exhibits a log2 fold c... | |
medium_hidden_intermediate_01480 | Human alphaherpesvirus 1 upregulates a gene that enables histone binding. In a study of monocytic leukemia cell lines (GSE114966), one such gene showed a log2 fold change of 2.722 and an adjusted p-value of 0.003767. Which protein is encoded by this gene? | E3 ubiquitin-protein ligase UHRF1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01480","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that enables histone binding. In a study of monocytic leukemia cell lines (GSE11... | |
medium_hidden_intermediate_01481 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and participates in the RHO GTPase cycle. This gene exhibits a log2 fold change of approximately 1.183 and an adjusted p-value of 4.56e-08. Which cellular component is this gene located in? | mitochondrion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01481","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and p... | |
medium_hidden_intermediate_01482 | A gene is upregulated by Primate bocaparvovirus 1 and is involved in the positive regulation of the apoptotic process. Experimental evidence for this gene reports a log2 fold change of 1.154 and an adjusted p-value of 0.02782. Which gene does this entity bind to? | TCF7L2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01482","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and is involved in the positive regulation of the apoptotic process. Exper... | |
medium_hidden_intermediate_01483 | A specific genomic variant, NM_015600.4(ABHD12):c.-6898_191+7002delinsCC, is associated with a gene that encodes a protein binding to YWHAE. Evidence regarding one such entity states: 'To elucidate further the signaling mechanisms utilized by p75NTR and a neuronal apoptosis-related protein, we screened for binding prot... | Protein BEX3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01483","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A specific genomic variant, NM_015600.4(ABHD12):c.-6898_191+7002delinsCC, is associated with a gene that encodes a protein b... | |
medium_hidden_intermediate_01484 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in G alpha (i) signalling events. One of these genes exhibits a log2 fold change of 1.119 and an adjusted p-value of 8.947e-05 in stomach tissue. Which biological process is this specific gene involved in? | G protein-coupled receptor signaling pathway | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01484","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in G alpha (i) signalling... | |
medium_hidden_intermediate_01485 | A gene is upregulated by Vaccinia virus and enables calcium ion binding. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately 6.99 and an adjusted p-value of approximately 0.000168. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01485","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Vaccinia virus and enables calcium ion binding. Experimental data for this gene in a cervical adeno... | |
medium_hidden_intermediate_01488 | In a study of monocytic leukemia cells (GSE114966), Human alphaherpesvirus 1 infection was found to upregulate a specific histone H2B variant gene, which in turn participates in TCF-dependent signaling in response to WNT. This specific gene exhibited a log2 fold change of 2.124 and an adjusted p-value of 0.009046. Whic... | Histone H2B type 1-C/E/F/G/I | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01488","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of monocytic leukemia cells (GSE114966), Human alphaherpesvirus 1 infection was found to upregulate a specific hi... | |
medium_hidden_intermediate_01492 | Pegivirus C is reported to downregulate a specific gene, which in turn interacts with STAU1. Experimental data for this intermediate gene in peripheral blood mononuclear cells (from study GSE131504) shows a log2 fold change of -1.806 and an adjusted p-value of 0.001091. Which protein is encoded by this gene? | Probable ATP-dependent RNA helicase DDX10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01492","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn interacts with STAU1. Experimental data for this inte... | |
medium_hidden_intermediate_01493 | Zika virus is reported to downregulate certain genes that are also associated with mammary neoplasms in animals via genomic alterations. One such gene exhibits a log2 fold change of -3.527 and an adjusted p-value of 0.005289 in glioma stem cells (study GSE114907). Which protein is encoded by this specific gene? | Ribosomal oxygenase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01493","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus is reported to downregulate certain genes that are also associated with mammary neoplasms in animals via genomic ... | |
medium_hidden_intermediate_01494 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus downregulates a gene that subsequently interacts with YWHAE. One such gene exhibits a log2 fold change of -1.227 and an adjusted p-value of 0.0006385. Which protein is encoded by this specific gene? | Protein phosphatase 1H | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01494","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus downregulates a gene that subsequently interacts... | |
medium_hidden_intermediate_01496 | Human immunodeficiency virus 1 downregulates a specific gene, which is subsequently associated with hyperplasia. Experimental data for this gene in macrophages (from study GSE108897) indicates a log2 fold change of approximately -1.047 and an adjusted p-value of 0.01684. Which disease is linked to this gene as a biomar... | carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01496","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a specific gene, which is subsequently associated with hyperplasia. Experimenta... | |
medium_hidden_intermediate_01497 | A gene is downregulated by Measles morbillivirus and associated with gastric cancer. Experimental data for this gene reports a log2 fold change of approximately -1.18 and an adjusted p-value of 0.001459. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01497","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Measles morbillivirus and associated with gastric cancer. Experimental data for this gene reports... | |
medium_hidden_intermediate_01499 | Zika virus downregulates a gene that participates in glycerophospholipid biosynthesis. Evidence for this gene reports a log2 fold change of -1.692 and an adjusted p-value of 0.009677. Which cell type is this gene enriched in? | mucosal-associated invariant T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01499","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in glycerophospholipid biosynthesis. Evidence for this gene reports a log2... | |
medium_hidden_intermediate_01500 | DDX5 interacts with a partner protein that possesses protein binding activity. Evidence indicates that this partner forms a complex with Drosha, known as the Microprocessor, which is essential for microRNA biogenesis. In which cell type is this partner protein enriched? | CD8-positive, alpha-beta memory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01500","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"DDX5 interacts with a partner protein that possesses protein binding activity. Evidence indicates that this partner forms a ... | |
medium_hidden_intermediate_01501 | Zika virus downregulates a gene that interacts with NUP214. In a study of glioma stem cells (GSE114907), one such gene exhibits a log2 fold change of approximately -1.27 and an adjusted p-value of 0.0067. Which protein is encoded by this gene? | SMAD family member 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01501","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with NUP214. In a study of glioma stem cells (GSE114907), one such gene exhib... | |
medium_hidden_intermediate_01504 | Zika virus upregulates a gene that enables RNA polymerase II cis-regulatory region sequence-specific DNA binding. Evidence for this gene reports a log2 fold change of 1.174 and an adjusted p-value of 0.03075. Which biological process is this gene involved in? | negative regulation of transcription by RNA polymerase II | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01504","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that enables RNA polymerase II cis-regulatory region sequence-specific DNA binding. Evidence f... | |
medium_hidden_intermediate_01505 | Human betaherpesvirus 5 downregulates a gene that interacts with KRAS. In a study of foreskin fibroblast cell lines (GSE111036), one such gene exhibits a log2 fold change of -1.448 and an adjusted p-value of 0.04918. Which protein is encoded by this gene? | EH domain-binding protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01505","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 downregulates a gene that interacts with KRAS. In a study of foreskin fibroblast cell lines (GSE1110... | |
medium_hidden_intermediate_01506 | Rhinovirus A infection leads to the downregulation of certain genes, which are subsequently involved in the negative regulation of cell population proliferation. In a study of cytotoxic T-lymphocytes (GSE106475), one such gene exhibited a log2 fold change of approximately -1.08 and an adjusted p-value of 0.0116. Which ... | Cyclic AMP-dependent transcription factor ATF-5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01506","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection leads to the downregulation of certain genes, which are subsequently involved in the negative regulat... | |
medium_hidden_intermediate_01507 | Hepacivirus C is reported to downregulate a gene that is located in the cytosol. Experimental data for one such gene shows a log2 fold change of -1.425 and an adjusted p-value of 1.141e-06. Which protein is encoded by this gene? | Caveolae-associated protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01507","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that is located in the cytosol. Experimental data for one such gene shows a... | |
medium_hidden_intermediate_01509 | Two genes are upregulated by Vaccinia virus and associated with astrocytoma (excluding glioblastoma). One of these genes exhibits a log2 fold change of 2.278 and an adjusted p-value of 3.165e-07 in cervical adenocarcinoma cell lines. Which cell type is enriched for this specific gene? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01509","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and associated with astrocytoma (excluding glioblastoma). One of these genes exh... | |
medium_hidden_intermediate_01510 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and subsequently interacts with AIFM1. Evidence for this gene reports a log2 fold change of approximately 2.45 and an adjusted p-value of 0.0067. Which protein is encoded by this gene? | Mitochondrial adenyl nucleotide antiporter SLC25A25 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01510","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and subsequent... | |
medium_hidden_intermediate_01512 | Two genes are structurally linked to Enterovirus A via a downregulation relationship and to Neutrophil via an enrichment relationship. One of these genes is associated with experimental data showing a log2 fold change of approximately -1.19 and an adjusted p-value of approximately 0.0016. Which gene corresponds to this... | COP1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01512","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Enterovirus A via a downregulation relationship and to Neutrophil via an enrichment rel... | |
medium_hidden_intermediate_01513 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via downregulation and to asthma via biomarker association. One of these genes exhibits a log2 fold change of -1.930 and an adjusted p-value of 0.01478 in a specific study. Which protein is encoded by this gene? | Neuron navigator 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01513","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via downregulation and to asthma via biomarker... | |
medium_hidden_intermediate_01514 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in Complex IV assembly. This specific gene exhibits a log2 fold change of approximately 1.106 and an adjusted p-value of 0.0001346. Which protein is encoded by this gene? | Cytochrome c oxidase subunit 5B, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01514","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in Complex IV ass... | |
medium_hidden_intermediate_01515 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to 'negative regulation of cell population proliferation' via an 'involved in' relationship. One of these genes has an associated expression profile showing a log2 fold change of -2.445 and ... | extracellular space | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01515","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_01517 | Human immunodeficiency virus 1 upregulates a gene that is located on the cytoplasmic side of the plasma membrane. Evidence for this specific gene reports a log2 fold change of 1.794 and an adjusted p-value of 0.02403. Which protein is encoded by this gene? | Protein tyrosine phosphatase type IVA 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01517","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is located on the cytoplasmic side of the plasma membrane. Evidence f... | |
medium_hidden_intermediate_01518 | A gene serves as a marker for CD1C+ B dendritic cells and is enriched in conventional dendritic cells. Expression data for this gene indicates a mean expression of 79.70 TPM, a z-score of 1.77, and a fold enrichment of 5.16. Which molecular function is enabled by this gene? | histamine N-methyltransferase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01518","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for CD1C+ B dendritic cells and is enriched in conventional dendritic cells. Expression data for t... | |
medium_hidden_intermediate_01520 | Rhinovirus A infection leads to the upregulation of specific genes that are involved in the cell surface receptor signaling pathway. One such gene exhibits a log2 fold change of 1.281 and an adjusted p-value of 0.03824 in bronchial epithelial cells. Which protein is encoded by this gene? | C-C motif chemokine 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01520","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection leads to the upregulation of specific genes that are involved in the cell surface receptor signaling ... | |
medium_hidden_intermediate_01521 | Two genes are linked to Influenza A virus via upregulation and to major depressive disorder via biomarker association. One of these genes exhibits a log2 fold change of approximately 1.354 and an adjusted p-value of 0.01559 in non-small cell lung adenocarcinoma cell lines. Which gene interacts with the gene identified ... | PFKFB4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01521","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Influenza A virus via upregulation and to major depressive disorder via biomarker association. One o... | |
medium_hidden_intermediate_01522 | COG7 interacts with a specific small GTPase that possesses protein binding activity. Evidence identifies this GTPase as a key factor that recruits the HOPS complex onto autophagic vesicles. Which protein is encoded by this gene? | Ras-related protein Rab-39A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01522","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"COG7 interacts with a specific small GTPase that possesses protein binding activity. Evidence identifies this GTPase as a ke... | |
medium_hidden_intermediate_01523 | Zika virus downregulates a gene that is involved in clathrin-dependent endocytosis. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -1.431 and an adjusted p-value of 0.01255. Which protein is encoded by this gene? | F-BAR and double SH3 domains protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01523","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in clathrin-dependent endocytosis. In a study of glioma stem cells (GSE1149... | |
medium_hidden_intermediate_01525 | Zika virus downregulates a specific gene that is located in the trans-Golgi network. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.243 and an adjusted p-value of 0.03182. Which biological process is this gene involved in? | negative regulation of cytokine production involved in inflammatory response | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01525","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is located in the trans-Golgi network. Experimental data for this gene in glio... | |
medium_hidden_intermediate_01526 | Two genes are upregulated by Human immunodeficiency virus 1 and enable actin binding. One of these genes shows a log2 fold change of 1.111 and an adjusted p-value of 0.01436 in a specific study. Which cell type is this gene enriched in? | mucosal-associated invariant T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01526","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and enable actin binding. One of these genes shows a log2 fold c... | |
medium_hidden_intermediate_01527 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and involved in protein homooligomerization. Evidence for this gene reports a log2 fold change of -1.470 and an adjusted p-value of 0.02607. Which protein is encoded by this gene? | Brain acid soluble protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01527","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and involved... | |
medium_hidden_intermediate_01528 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in retrograde transport from endosome to Golgi. Evidence for one such gene reports a log2 fold change of 1.141 and an adjusted p-value of 0.004023. Which protein is encoded by that gene? | TBC1 domain family member 10A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01528","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in retrograde transport from endos... |
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