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medium_hidden_intermediate_01529 | Hepacivirus C is reported to upregulate a gene that participates in the pathway 'Signaling by Rho GTPases, Miro GTPases and RHOBTB3'. Experimental evidence for this specific gene shows a log2 fold change of approximately 1.011 and an adjusted p-value of 0.0001046. Which protein is encoded by this gene? | Protein FAM135A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01529","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to upregulate a gene that participates in the pathway 'Signaling by Rho GTPases, Miro GTPases and ... | |
medium_hidden_intermediate_01530 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes involved in respiratory electron transport. One such gene exhibited a log2 fold change of 1.662 and an adjusted p-value of 6.666e-06. Which protein is encoded by this specific gene? | Cytochrome c oxidase assembly protein COX11, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01530","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes... | |
medium_hidden_intermediate_01534 | A specific protein entity is structurally linked to FYN via an interaction and is associated with the molecular function of protein binding. Contextual evidence states: 'Here, we report that the novel Src homology (SH) 3/SH2 ligand-Uncoordinated 119 associates with CD3 and CD4, and activates Lck and Fyn.' Based on this... | non-classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01534","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A specific protein entity is structurally linked to FYN via an interaction and is associated with the molecular function of ... | |
medium_hidden_intermediate_01535 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which in turn interacts with PLK1. This gene exhibits a log2 fold change of approximately -1.49 and an adjusted p-value of 0.0425. Which protein is encoded by this gene? | Spindle and kinetochore-associated protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01535","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_01536 | In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated and participates in Heparan sulfate/heparin (HS-GAG) metabolism. This gene exhibits a log2 fold change of approximately 1.41 and an adjusted p-value of approximately 0.011. Which cellular component is this gene loca... | Golgi lumen | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01536","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated and participates in... | |
medium_hidden_intermediate_01537 | Cardiovirus A is reported to downregulate a specific gene, which is in turn associated with carcinoma. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) indicates a log2 fold change of -3.094 and an adjusted p-value of 0.01732. Which protein is encoded by this gene? | DEP domain-containing protein 1A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01537","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A is reported to downregulate a specific gene, which is in turn associated with carcinoma. Experimental data for... | |
medium_hidden_intermediate_01538 | A gene is upregulated by Zika virus and enriched in neutrophils. Evidence for this gene reports a log2 fold change of 2.376 and an adjusted p-value of 0.004761. Which disease is connected to this gene through genomic alterations? | thyroid cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01538","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Zika virus and enriched in neutrophils. Evidence for this gene reports a log2 fold change of 2.376 ... | |
medium_hidden_intermediate_01539 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with CDC42. One of these genes exhibits a log2 fold change of approximately -1.36 and an adjusted p-value of 0.0022 in lung tissue. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01539","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with CDC42. One of these g... | |
medium_hidden_intermediate_01540 | A specific gene serves as a marker for Natural killer T (NKT) cells and is associated with lung carcinoma. Evidence indicates that this gene encodes a target enzyme, which, along with Thymidylate synthase, is inhibited by pemetrexed, an antifolate used to treat advanced non-small-cell lung cancer. Which disease is conn... | malaria | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01540","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A specific gene serves as a marker for Natural killer T (NKT) cells and is associated with lung carcinoma. Evidence indicate... | |
medium_hidden_intermediate_01542 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to the process 'ChREBP activates metabolic gene expression' via a participation relationship. One of these genes was reported in a study (GSE160351) involving monocytes, with a log2 fold chang... | 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01542","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship ... | |
medium_hidden_intermediate_01543 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene involved in DNA alkylation repair. This specific gene exhibited a log2 fold change of approximately 1.35 and an adjusted p-value of 7.34e-05. Which protein is encoded by this gene? | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01543","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene involve... | |
medium_hidden_intermediate_01544 | Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to conventional dendritic cells via an enrichment relationship. One of these genes exhibits a log2 fold change of -4.645 and an adjusted p-value of 0.02285 in a specific study context. Which disease is associated w... | colorectal carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01544","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to conventional de... | |
medium_hidden_intermediate_01545 | Pegivirus C is reported to downregulate a gene that is associated with adenocarcinoma. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibits a log2 fold change of -1.599 and an adjusted p-value of 0.00835. Which protein is encoded by this specific gene? | Thromboxane-A synthase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01545","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is associated with adenocarcinoma. In a study of peripheral blood mononu... | |
medium_hidden_intermediate_01546 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene involved in intracellular signal transduction. This gene exhibited a log2 fold change of -2.677 and an adjusted p-value of 0.03476. Which protein is encoded by this gene? | cGMP-dependent protein kinase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01546","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene involved in ... | |
medium_hidden_intermediate_01547 | Measles morbillivirus upregulates a gene that is involved in protein phosphorylation. Evidence for one such gene reports a log2 fold change of 2.165 and an adjusted p-value of 0.04586. Which disease is associated with that gene? | lung carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01547","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is involved in protein phosphorylation. Evidence for one such gene reports a l... | |
medium_hidden_intermediate_01548 | Hepacivirus C upregulates a gene that participates in TRIF (TICAM1)-mediated TLR4 signaling. Evidence for one such gene reports a log2 fold change of 1.343 and an adjusted p-value of 1.433e-09. Which protein is encoded by that gene? | Interleukin-1 receptor-associated kinase-like 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01548","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in TRIF (TICAM1)-mediated TLR4 signaling. Evidence for one such gene repo... | |
medium_hidden_intermediate_01549 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (SARS-CoV-2), gene expression analysis identified a gene that is downregulated by the virus and involved in the antimicrobial humoral immune response mediated by antimicrobial peptides. This specific gene exhibited a log2 fold ... | C-X-C motif chemokine 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01549","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (SARS-CoV-2), gene expression a... | |
medium_hidden_intermediate_01550 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to GRIN1 via a binding relationship. One of these genes is associated with experimental data showing a log2 fold change of approximately 1.024 and an adjusted p-value of 0.009042. Which protei... | Amyloid-beta A4 precursor protein-binding family A member 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01550","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship ... | |
medium_hidden_intermediate_01553 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that enables low-density lipoprotein particle binding. One such gene exhibits a log2 fold change of 1.972 and an adjusted p-value of 0.007572. Which protein is encoded by this specific gene? | Cadherin-13 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01553","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that enables low-density lipoprotei... | |
medium_hidden_intermediate_01554 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in protein localization to chromatin. Evidence for one such gene reports a log2 fold change of 2.678 and an adjusted p-value of 0.01869. Which protein is encoded by that gene? | DNA-dependent ATPase/E3 ubiquitin-protein ligase HLTF | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01554","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in protein localization to chromat... | |
medium_hidden_intermediate_01555 | A gene serves as a marker for monocytes and is associated with leukemia. Evidence indicates that this specific gene was initially described in the context of in vitro differentiation processes of endometrial adenocarcinoma and leukemia cells. Which disease is linked to this gene via a biomarker relationship? | endometrial carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01555","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for monocytes and is associated with leukemia. Evidence indicates that this specific gene was init... | |
medium_hidden_intermediate_01556 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with UBE2L3. One of these genes exhibits a log2 fold change of 2.533 and an adjusted p-value of 0.01343 in a specific study. Which protein is encoded by this gene? | E3 ubiquitin-protein ligase RNF144B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01556","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with UBE2L3. One of these ge... | |
medium_hidden_intermediate_01557 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection was found to upregulate certain genes located in the endoplasmic reticulum membrane. One such gene exhibited a log2 fold change of 1.143 and an adjusted p-value of 0.0009466. Which protein is encoded by this specific gene? | ER membrane protein complex subunit 9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01557","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection was found to upregulate certain genes ... | |
medium_hidden_intermediate_01558 | A gene is upregulated by Human immunodeficiency virus 1 and participates in the transport of small molecules. Evidence for this gene reports a log2 fold change of 1.022 and an adjusted p-value of 0.0003889. Which cell type is this gene enriched in? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01558","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human immunodeficiency virus 1 and participates in the transport of small molecules. Evidence for t... | |
medium_hidden_intermediate_01559 | Severe acute respiratory syndrome-related coronavirus is reported to downregulate a gene that is located in the nuclear chromosome. Evidence for one such gene indicates a log2 fold change of -1.268 and an adjusted p-value of 0.002703. Which protein is encoded by this gene? | DNA topoisomerase 2-alpha | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01559","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus is reported to downregulate a gene that is located in the nuclear chro... | |
medium_hidden_intermediate_01563 | Two drugs are known to interact with both Ethinylestradiol and Estrone sulfate. One of these drugs is described in a study where testosterone (T) slightly decreased STS activity after direct incubation but increased local estrogen formation after 24 hours; this increase was attenuated and partly reversed by the drug in... | breast cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01563","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two drugs are known to interact with both Ethinylestradiol and Estrone sulfate. One of these drugs is described in a study w... | |
medium_hidden_intermediate_01566 | Two genes are upregulated by Vaccinia virus and participate in the regulation of lipid metabolism by PPARalpha. One of these genes exhibits a log2 fold change of 1.105 and an adjusted p-value of 1.726e-08 in cervical adenocarcinoma cell lines. Which disease is associated with this specific gene as a biomarker? | ovarian neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01566","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and participate in the regulation of lipid metabolism by PPARalpha. One of these... | |
medium_hidden_intermediate_01567 | Human alphaherpesvirus 1 upregulates a specific gene that is enriched in eosinophils. Evidence for this gene reports a log2 fold change of 1.580 and an adjusted p-value of 0.01066. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01567","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a specific gene that is enriched in eosinophils. Evidence for this gene reports a log2 ... | |
medium_hidden_intermediate_01568 | PTK2B interacts with a protein that enables protein binding. Evidence indicates that the N-terminal domain of this protein directly associates in vitro with the extreme C-terminal region (residue 801 to the end) of CAKbeta. Which disease is associated with the entity described by this evidence? | breast carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01568","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"PTK2B interacts with a protein that enables protein binding. Evidence indicates that the N-terminal domain of this protein d... | |
medium_hidden_intermediate_01569 | A gene is downregulated by Primate bocaparvovirus 1 and is involved in intracellular signal transduction. Experimental evidence for this gene reports a log2 fold change of -1.944 and an adjusted p-value of 0.001307. Which protein is encoded by this gene? | Disks large homolog 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01569","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and is involved in intracellular signal transduction. Experimental evide... | |
medium_hidden_intermediate_01570 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with SLC39A4. One of these genes shows a log2 fold change of 1.365 and an adjusted p-value of 5.521e-09 in a specific study. Which disease is associated with this gene? | pituitary gigantism | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01570","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with SLC39A4. One of these g... | |
medium_hidden_intermediate_01571 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to childhood acute lymphoblastic leukemia as biomarkers. One of these genes exhibits a log2 fold change of 3.772 and an adjusted p-value of 0.03785 in a specific study. Which protein is encoded by this gene? | Double homeobox protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01571","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to childhood acute lympho... | |
medium_hidden_intermediate_01574 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables lipid binding. Evidence for this gene reports a log2 fold change of 1.128 and an adjusted p-value of 0.003294. Which cellular component is this gene located in? | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01574","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables lipid binding. Evidence for this ... | |
medium_hidden_intermediate_01575 | Measles morbillivirus upregulates a gene that participates in protein localization. Evidence for one such gene reports a log2 fold change of 1.151 and an adjusted p-value of 0.007426. Which protein is encoded by that gene? | GrpE protein homolog 2, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01575","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that participates in protein localization. Evidence for one such gene reports a log... | |
medium_hidden_intermediate_01578 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to skin cancer via an 'associated with' relationship. One of these genes is reported in a study (GSE151803) with a log2 fold change of -2.539 and an adjusted p-value of 1.055e-06. Which prot... | Elafin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01578","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_01579 | Hepacivirus C upregulates a gene that participates in the RHOA GTPase cycle. In a study of hepatocytes (GSE132606), one such gene exhibits a log2 fold change of 2.755 and an adjusted p-value of 0.004441. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01579","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in the RHOA GTPase cycle. In a study of hepatocytes (GSE132606), one such... | |
medium_hidden_intermediate_01581 | STRAP interacts with a protein that enables protein binding. Evidence indicates that this protein also interacts directly with several of the Sm core proteins. Which protein is encoded by the gene corresponding to this entity? | Gem-associated protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01581","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"STRAP interacts with a protein that enables protein binding. Evidence indicates that this protein also interacts directly wi... | |
medium_hidden_intermediate_01582 | RAB25 interacts with a protein that is enriched in neutrophils. Experimental evidence indicates that this protein, along with three others, associates with wild-type Rab11a, dominant active Rab11a (Rab11aS20V), Rab11b, and Rab25. Which protein is encoded by the gene corresponding to this interacting entity? | Rab11 family-interacting protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01582","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"RAB25 interacts with a protein that is enriched in neutrophils. Experimental evidence indicates that this protein, along wit... | |
medium_hidden_intermediate_01583 | Pegivirus C is reported to downregulate a specific gene, which in turn participates in ATP-dependent chromatin remodeling. Experimental data from a study on peripheral blood mononuclear cells (GSE131504) indicates that this intermediate gene has a log2 fold change of approximately -1.13 and an adjusted p-value of 0.016... | STK4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01583","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn participates in ATP-dependent chromatin remodeling. E... | |
medium_hidden_intermediate_01585 | A gene is upregulated by Human gammaherpesvirus 8 and binds to UBB. Experimental data for this gene in a non-Hodgkin lymphoma cell line (study GSE119608) reports a log2 fold change of approximately 1.21 and an adjusted p-value of 0.013. Which cellular component is this gene located in? | centrosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01585","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human gammaherpesvirus 8 and binds to UBB. Experimental data for this gene in a non-Hodgkin lymphom... | |
medium_hidden_intermediate_01587 | Two genes are downregulated by Vaccinia virus and participate in the RAC1 GTPase cycle. One of these genes exhibits a log2 fold change of -1.485 and an adjusted p-value of 0.0006996 in cervical adenocarcinoma cells. Which cell type is enriched for this specific gene? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01587","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Vaccinia virus and participate in the RAC1 GTPase cycle. One of these genes exhibits a log2 f... | |
medium_hidden_intermediate_01588 | Human immunodeficiency virus 1 upregulates a gene that participates in disease. Evidence for this gene in macrophages (study GSE108897) reports a log2 fold change of 1.511 and an adjusted p-value of 0.003973. Which protein does this gene product bind to? | CAST | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01588","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in disease. Evidence for this gene in macrophages (study... | |
medium_hidden_intermediate_01589 | Pegivirus C is reported to downregulate a specific gene, which in turn participates in Cytokine Signaling in the Immune system. Experimental data for this gene in peripheral blood mononuclear cells (from study GSE131504) shows a log2 fold change of -1.235 and an adjusted p-value of 0.009671. Which protein is encoded by... | Alpha-taxilin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01589","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn participates in Cytokine Signaling in the Immune syst... | |
medium_hidden_intermediate_01592 | In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and enables zinc ion binding. This specific gene exhibits a log2 fold change of approximately -1.88 and an adjusted p-value of approximately 0.0085. Which protein is encoded by this gene? | S-methylmethionine--homocysteine S-methyltransferase BHMT2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01592","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and enab... | |
medium_hidden_intermediate_01593 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Ion channel transport. Experimental data for this gene in monocytes shows a log2 fold change of -1.169 and an adjusted p-value of 0.0191. Which biological process is this gene involved in? | positive regulation of cold-induced thermogenesis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01593","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Ion channel transport. ... | |
medium_hidden_intermediate_01594 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and localized to the nucleolus. This gene exhibits a log2 fold change of 1.816 and an adjusted p-value of 1.903e-05. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01594","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and l... | |
medium_hidden_intermediate_01596 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the negative regulation of cold-induced thermogenesis. Experimental data for this gene in bronchial epithelial cells show a log2 fold change of approximately 3.13 and an adjusted p-value of 0.0444. Which protein is encoded... | Acyl-coenzyme A thioesterase 13 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01596","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the negative regulation of... | |
medium_hidden_intermediate_01597 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in DNA repair. Evidence for this gene reports a log2 fold change of approximately 1.096 and an adjusted p-value of 0.02914. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01597","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in DNA repair. Evidence for this ... | |
medium_hidden_intermediate_01600 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in the synthesis of DNA. One of these genes exhibits a log2 fold change of -1.704 and an adjusted p-value of 0.001904 in a specific study. Which cell type is enriched for this specific gene? | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01600","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in the synthesis of DNA... | |
medium_hidden_intermediate_01601 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the downregulation of a specific gene that enables sequence-specific double-stranded DNA binding. This gene exhibits a log2 fold change of approximately -1.72 and an adjusted p-value of approximately 0.024. In which cellular compo... | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01601","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the downregulation of a specific g... | |
medium_hidden_intermediate_01602 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and located in the lysosome was found to have a log2 fold change of approximately 1.137 and an adjusted p-value of approximately 0.003. Which disease is associated with this gene as a biomarker? | stroke disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01602","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and located in the lysosom... | |
medium_hidden_intermediate_01604 | Measles morbillivirus upregulates a gene that is involved in intracellular signal transduction. Experimental data for this gene shows a log2 fold change of 1.543 and an adjusted p-value of 0.0006864. What molecular function is enabled by this gene? | C-type glycerophospholipase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01604","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is involved in intracellular signal transduction. Experimental data for this g... | |
medium_hidden_intermediate_01606 | Two genes are downregulated by Vaccinia virus and both enable protein kinase binding. One of these genes exhibits a log2 fold change of -1.812 and an adjusted p-value of 0.002781 in cervical adenocarcinoma cell lines. Which disease is associated with this specific gene as a biomarker? | systemic lupus erythematosus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01606","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Vaccinia virus and both enable protein kinase binding. One of these genes exhibits a log2 fol... | |
medium_hidden_intermediate_01607 | Human alphaherpesvirus 1 upregulates a gene that enables kinesin binding. In a study of monocytic leukemia cell lines (GSE114966), one such gene showed a log2 fold change of 2.613 and an adjusted p-value of 0.004499. Which protein is encoded by this gene? | Protein FAM83D | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01607","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that enables kinesin binding. In a study of monocytic leukemia cell lines (GSE11... | |
medium_hidden_intermediate_01612 | Pegivirus C is reported to downregulate a specific gene, which in turn participates in PLC beta mediated events. Experimental data for this gene indicates a log2 fold change of approximately -1.47 and an adjusted p-value of 0.042. In which cell type is this gene enriched? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01612","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn participates in PLC beta mediated events. Experimenta... | |
medium_hidden_intermediate_01613 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in actin cytoskeleton organization. One of these genes was reported in a study of bronchial epithelial cells (GSE150819) with a log2 fold change of approximately 1.85 and an adjusted p-value of approximately 0.022. What ... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01613","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in actin cytoskeleton or... | |
medium_hidden_intermediate_01614 | In a study of umbilical vein endothelial cells (GSE119608), a gene is identified as being downregulated by Human gammaherpesvirus 8 and located in the mitochondrion. This specific gene exhibits a log2 fold change of -1.951 and an adjusted p-value of 3.774e-06. Which protein is encoded by this gene? | Valine--tRNA ligase, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01614","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of umbilical vein endothelial cells (GSE119608), a gene is identified as being downregulated by Human gammaherpes... | |
medium_hidden_intermediate_01616 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables DNA-binding transcription activator activity, RNA polymerase II-specific. Experimental data for this gene reports a log2 fold change of -1.602 and an adjusted p-value of 0.0002564. Which disease is associated with this gene as ... | alcohol abuse | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01616","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables DNA-binding transcription activ... | |
medium_hidden_intermediate_01617 | A gene is upregulated by Measles morbillivirus and located in the cytosol. Experimental data for this gene reports a log2 fold change of 3.126 and an adjusted p-value of 0.01294. Which disease is associated with this gene through genomic alterations? | carcinoma of esophagus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01617","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and located in the cytosol. Experimental data for this gene reports a log2 fo... | |
medium_hidden_intermediate_01621 | Two genes are downregulated by Pegivirus C and are involved in the G2/M transition of the mitotic cell cycle. One of these genes exhibits a log2 fold change of -1.011 and an adjusted p-value of 0.003455 in peripheral blood mononuclear cells. Which disease is associated with this specific gene? | breast carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01621","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and are involved in the G2/M transition of the mitotic cell cycle. One of these g... | |
medium_hidden_intermediate_01623 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the apoptotic process. Experimental data for this gene shows a log2 fold change of -2.349 and an adjusted p-value of 0.001045. Which disease is associated with this gene as a biomarker? | lung carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01623","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the apoptotic process. E... | |
medium_hidden_intermediate_01624 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate specific genes involved in vesicle-mediated transport. One such gene exhibited a log2 fold change of approximately 1.48 and an adjusted p-value of 0.009. Which protein does this specific gene product interact with? | CYTIP | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01624","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate specific genes involved in... | |
medium_hidden_intermediate_01626 | Pegivirus C is reported to downregulate a gene that enables microtubule binding. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -1.95 and an adjusted p-value of 0.0442. Which protein is encoded by this specific gene? | MAP7 domain-containing protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01626","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that enables microtubule binding. In a study of peripheral blood mononuclear ... | |
medium_hidden_intermediate_01627 | A gene is upregulated by Primate bocaparvovirus 1 and associated with invasive breast carcinoma. Evidence for this gene in a non-Hodgkin lymphoma cell line (study GSE119608) reports a log2 fold change of 1.238 and an adjusted p-value of 0.04682. Which protein is encoded by this gene? | Breast cancer anti-estrogen resistance protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01627","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and associated with invasive breast carcinoma. Evidence for this gene in a... | |
medium_hidden_intermediate_01629 | Zika virus downregulates a gene that subsequently binds to FAM50A. In a study of glioma stem cells (GSE114907), this intermediate gene exhibited a log2 fold change of -1.811 and an adjusted p-value of 0.01163. Which protein is encoded by this gene? | Protein CASC3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01629","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that subsequently binds to FAM50A. In a study of glioma stem cells (GSE114907), this interme... | |
medium_hidden_intermediate_01631 | In a study of non-small cell lung adenocarcinoma cell lines (GSE106279), Influenza A virus infection was found to downregulate certain genes that are enriched in neutrophils. One such gene exhibited a log2 fold change of approximately -1.040 and an adjusted p-value of 0.0165. Which protein is encoded by this specific g... | PDZ and LIM domain protein 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01631","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE106279), Influenza A virus infection was found to downregula... | |
medium_hidden_intermediate_01634 | Pegivirus C is reported to downregulate a specific gene, which in turn enables transcription corepressor binding. Experimental data for this gene in peripheral blood mononuclear cells (from study GSE131504) shows a log2 fold change of approximately -1.08 and an adjusted p-value of approximately 0.0057. Which protein is... | THAP domain-containing protein 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01634","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn enables transcription corepressor binding. Experiment... | |
medium_hidden_intermediate_01636 | In a study of non-Hodgkin lymphoma cell lines (GSE119608), Human gammaherpesvirus 8 was found to upregulate a gene that enables receptor ligand activity. One such gene exhibited a log2 fold change of approximately 3.116 and an adjusted p-value of 0.02236. Which protein is encoded by this specific gene? | UL16-binding protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01636","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-Hodgkin lymphoma cell lines (GSE119608), Human gammaherpesvirus 8 was found to upregulate a gene that enab... | |
medium_hidden_intermediate_01637 | Severe acute respiratory syndrome-related coronavirus upregulates a specific gene product, which in turn participates in the positive epigenetic regulation of rRNA expression. Experimental data for this intermediate entity reports a log2 fold change of 2.270 and an adjusted p-value of 0.002264. Which protein is encoded... | Histone H3.2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01637","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a specific gene product, which in turn participates in the... | |
medium_hidden_intermediate_01638 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the type I interferon-mediated signaling pathway. Evidence for one such gene reports a log2 fold change of 9.804 and an adjusted p-value of 0.01792. Which protein is encoded by that gene? | Interferon alpha-21 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01638","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the type I interferon-mediated ... | |
medium_hidden_intermediate_01639 | Two genes are structurally linked to Enterovirus A via upregulation and to prostate cancer via association. One of these genes exhibits a log2 fold change of approximately 5.93 and an adjusted p-value of 0.0035 in rhabdomyosarcoma cells. Which cellular component is the location of this specific gene? | extracellular space | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01639","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Enterovirus A via upregulation and to prostate cancer via association. One of these gen... | |
medium_hidden_intermediate_01640 | A gene is upregulated by Primate bocaparvovirus 1 and participates in the RAC3 GTPase cycle. Evidence for this gene reports a log2 fold change of 1.317 and an adjusted p-value of 0.01594. Which cell type is this gene enriched in? | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01640","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and participates in the RAC3 GTPase cycle. Evidence for this gene reports ... | |
medium_hidden_intermediate_01641 | Two distinct proteins are known to interact with ABRAXAS1 and participate in the DNA Double Strand Break Response. One of these proteins is the subject of evidence stating: 'We provided evidence that NBA1 interacts with a partner protein through a C-terminal conserved motif of the NBA1 protein and a C-terminal UEV doma... | BRISC and BRCA1-A complex member 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01641","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct proteins are known to interact with ABRAXAS1 and participate in the DNA Double Strand Break Response. One of th... | |
medium_hidden_intermediate_01643 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes that enable structural molecule activity. One such gene exhibited a log2 fold change of 1.909 and an adjusted p-value of 4.951e-05. Which protein is encoded by this specific gene? | Tubulin gamma-2 chain | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01643","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes... | |
medium_hidden_intermediate_01644 | Hepacivirus C infection is associated with the upregulation of specific genes that are enriched in natural killer cells. One such gene exhibits a log2 fold change of 1.753 and an adjusted p-value of 0.0004019 in hepatocytes. Which protein is encoded by this gene? | Protein Smaug homolog 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01644","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C infection is associated with the upregulation of specific genes that are enriched in natural killer cells. One... | |
medium_hidden_intermediate_01645 | Human immunodeficiency virus 1 upregulates a gene that participates in sphingolipid de novo biosynthesis. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of approximately 3.20 and an adjusted p-value of 0.0036. Which disease is associated with this gene as a biomarker? | malignant pancreatic neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01645","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in sphingolipid de novo biosynthesis. Evidence for this ... | |
medium_hidden_intermediate_01646 | In a study of vascular endothelial cells (GSE16354), a specific gene is downregulated by Human gammaherpesvirus 8 and its protein product binds to SYK. This gene exhibits a log2 fold change of -1.008 and an adjusted p-value of 0.03533. Which protein is encoded by this gene? | Immunoglobulin heavy constant mu | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01646","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of vascular endothelial cells (GSE16354), a specific gene is downregulated by Human gammaherpesvirus 8 and its pr... | |
medium_hidden_intermediate_01649 | A gene is upregulated by Hepacivirus C and enriched in memory B cells. Evidence for this gene reports a log2 fold change of 3.062 and an adjusted p-value of 0.0004932. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01649","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Hepacivirus C and enriched in memory B cells. Evidence for this gene reports a log2 fold change of ... | |
medium_hidden_intermediate_01650 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables metallopeptidase activity. Experimental data for this gene reports a log2 fold change of -1.127 and an adjusted p-value of 0.02403. Which disease is associated with this gene? | lung adenocarcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01650","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables metallopeptidase activity. Expe... | |
medium_hidden_intermediate_01652 | In a study of Influenza A virus infection, a specific gene is upregulated by the virus and its product interacts with HSPA1B. Evidence for this gene reports a log2 fold change of approximately 1.134 and an adjusted p-value of 0.04709. Which protein is encoded by this gene? | F-box only protein 10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01652","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is upregulated by the virus and its product interacts with HSPA1B... | |
medium_hidden_intermediate_01653 | Zika virus is reported to downregulate a specific gene that participates in cardiac conduction. Experimental data for this gene in glioblastoma multiforme cancer stem cells show a log2 fold change of approximately -1.24 and an adjusted p-value of 0.0302. Which disease is associated with this gene? | depressive disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01653","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus is reported to downregulate a specific gene that participates in cardiac conduction. Experimental data for this g... | |
medium_hidden_intermediate_01654 | In a study of macrophages (GSE108897), two genes are identified as being downregulated by Human immunodeficiency virus 1 and participating in the Toll Like Receptor 9 (TLR9) Cascade. One of these genes exhibits a log2 fold change of approximately -1.99 and an adjusted p-value of approximately 0.0061. Which protein is e... | NF-kappa-B inhibitor-interacting Ras-like protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01654","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), two genes are identified as being downregulated by Human immunodeficiency virus 1 and... | |
medium_hidden_intermediate_01655 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Glycerophospholipid biosynthesis. Experimental evidence for this gene reports a log2 fold change of 1.184 and an adjusted p-value of 0.003842. Which protein is encoded by this gene? | Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01655","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Glycerophospholipid biosy... | |
medium_hidden_intermediate_01657 | Pegivirus C downregulates a gene that is involved in the nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Evidence for this specific gene reports a log2 fold change of -1.088 and an adjusted p-value of 0.04441. Which cellular component is this gene located in? | perinuclear region of cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01657","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that is involved in the nuclear-transcribed mRNA catabolic process, nonsense-mediated decay... | |
medium_hidden_intermediate_01658 | A pharyngeal neoplasm is localized to a structure that is a structure with developmental contribution from neural crest. Evidence concerning one such entity reports that it is a cranial nerve that branches into the lateral (to body sense organs) and the intestino-accessorial (to the skin, muscles of shoulder, hyoid, la... | gustatory system | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01658","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A pharyngeal neoplasm is localized to a structure that is a structure with developmental contribution from neural crest. Evi... | |
medium_hidden_intermediate_01659 | Human alphaherpesvirus 1 upregulates a gene that binds to MCM5. In a study of monocytic leukemia cell lines (GSE114966), one such gene exhibited a log2 fold change of 3.049 and an adjusted p-value of 0.008535. Which protein is encoded by this specific gene? | DNA replication complex GINS protein SLD5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01659","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that binds to MCM5. In a study of monocytic leukemia cell lines (GSE114966), one... | |
medium_hidden_intermediate_01660 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene, which is subsequently involved in DNA replication. This gene exhibited a log2 fold change of approximately 1.537 and an adjusted p-value of 0.02807. Which protein is encoded by this gene? | AFG2-interacting ribosome maturation factor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01660","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene, which is ... | |
medium_hidden_intermediate_01661 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in biological oxidations. One such gene exhibits a log2 fold change of approximately 1.20 and an adjusted p-value of approximately 0.016. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01661","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in biological oxi... | |
medium_hidden_intermediate_01663 | Zaire ebolavirus infection leads to the upregulation of several genes whose products are located in the membrane. In a study of retinal pigment epithelium cells (GSE100839), one such upregulated gene exhibited a log2 fold change of approximately 1.798 and an adjusted p-value of 2.997e-05. Which protein is encoded by th... | Apolipoprotein L3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01663","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus infection leads to the upregulation of several genes whose products are located in the membrane. In a study... | |
medium_hidden_intermediate_01664 | Human betaherpesvirus 5 upregulates a gene that is involved in the defense response to virus. Evidence for this gene in study GSE11408 reports a log2 fold change of approximately 5.075 and an adjusted p-value of 0.003384. Which cell type is this gene enriched in? | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01664","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that is involved in the defense response to virus. Evidence for this gene in stud... | |
medium_hidden_intermediate_01665 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is located in the mitochondrial inner membrane. Evidence for this gene reports a log2 fold change of 1.894 and an adjusted p-value of 0.03951. Which molecular function is enabled by this gene? | mitochondrial large ribosomal subunit binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01665","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is located in the mitochondrial inner mem... | |
medium_hidden_intermediate_01667 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables transcription corepressor activity. Evidence for one such gene reports a log2 fold change of 1.033 and an adjusted p-value of 3.744e-06. Which protein is encoded by that gene? | N-lysine methyltransferase KMT5A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01667","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables transcription corepressor activity. Ev... | |
medium_hidden_intermediate_01670 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with COPS5. One of these genes shows a log2 fold change of 1.729 and an adjusted p-value of 0.02061 in a specific study. Which disease is associated with this gene? | diabetes mellitus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01670","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with COPS5. One of these gen... | |
medium_hidden_intermediate_01671 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in deubiquitination. One of these genes shows a log2 fold change of 1.027 and an adjusted p-value of 0.000514 in a specific study. Which disease is associated with this specific gene? | neurodevelopmental disorder with hypotonia and seizures | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01671","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in deubiquitination. One ... | |
medium_hidden_intermediate_01672 | Human immunodeficiency virus 1 upregulates a gene that is associated with carcinoma. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of approximately 1.18 and an adjusted p-value of 0.009. Which protein is encoded by this gene? | Receptor-type tyrosine-protein phosphatase gamma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01672","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is associated with carcinoma. Evidence for this gene in macrophages (... | |
medium_hidden_intermediate_01675 | Cardiovirus A downregulates a gene that participates in the mitotic cell cycle. In a study of cervical adenocarcinoma cell lines (GSE122967), one such gene exhibits a log2 fold change of approximately -1.32 and an adjusted p-value of approximately 0.032. Which protein is encoded by this specific gene? | Ribonucleoside-diphosphate reductase subunit M2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01675","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A downregulates a gene that participates in the mitotic cell cycle. In a study of cervical adenocarcinoma cell l... | |
medium_hidden_intermediate_01676 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and involved in Hemostasis was found to have a log2 fold change of 6.985 and an adjusted p-value of 2.127e-08. Which molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01676","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and involved in Hemostasis... | |
medium_hidden_intermediate_01677 | In a study of lung cells (GSE155241), Severe acute respiratory syndrome-related coronavirus was found to downregulate a specific gene, which in turn interacts with TOP3B. This gene exhibited a log2 fold change of approximately -1.99 and an adjusted p-value of 0.0069. Which disease is associated with this gene as a biom... | malignant colon neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01677","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells (GSE155241), Severe acute respiratory syndrome-related coronavirus was found to downregulate a spec... | |
medium_hidden_intermediate_01679 | Measles morbillivirus upregulates a gene that is involved in the negative regulation of the apoptotic process. Evidence for one such gene reports a log2 fold change of approximately 1.20 and an adjusted p-value of approximately 0.00056. In which cell type is this specific gene enriched? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01679","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is involved in the negative regulation of the apoptotic process. Evidence for ... | |
medium_hidden_intermediate_01680 | Hepacivirus C is reported to downregulate a specific gene, which in turn participates in Signaling by GPCR. Experimental data for this gene shows a log2 fold change of -1.334 and an adjusted p-value of 0.0169. Which protein is encoded by this gene? | Gastric inhibitory polypeptide | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01680","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a specific gene, which in turn participates in Signaling by GPCR. Experimental dat... |
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