qa_id stringlengths 24 32 | question stringlengths 156 1.14k | answer stringlengths 3 134 | level stringclasses 1
value | subtype stringclasses 3
values | source_medium_qa_id stringclasses 1
value | record_json stringlengths 13.6k 214k |
|---|---|---|---|---|---|---|
medium_hidden_intermediate_01681 | H2AX interacts with a specific protein that enables protein binding. Evidence indicates that during cell division, this protein directly binds to and co-localizes with KIF4A (a nuclear motor protein involved in lung carcinogenesis) to form a functional complex. Which disease is associated with this protein through geno... | hypertensive disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01681","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"H2AX interacts with a specific protein that enables protein binding. Evidence indicates that during cell division, this prot... | |
medium_hidden_intermediate_01682 | Two genes are upregulated by Vaccinia virus and linked to coronary artery disorder via genomic alterations. One of these genes shows a log2 fold change of approximately 4.02 and an adjusted p-value of 2.42e-06 in cervical adenocarcinoma cell lines (study GSE11238). Which disease is associated with this specific gene? | adenoviridae infectious disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01682","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and linked to coronary artery disorder via genomic alterations. One of these gen... | |
medium_hidden_intermediate_01683 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in the pathway where defective B3GALTL causes PpS. Evidence for this gene reports a log2 fold change of -3.465 and an adjusted p-value of 0.00514. Which disease is associated with this gene? | arthrogryposis, distal, type 12 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01683","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in the pathway where defec... | |
medium_hidden_intermediate_01684 | Measles morbillivirus upregulates a gene that is enriched in mucosa-associated invariant T (MAIT) cells. Evidence for one such gene reports a log2 fold change of 1.643 and an adjusted p-value of 0.0005268. Which protein is encoded by that gene? | Myb-related protein A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01684","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is enriched in mucosa-associated invariant T (MAIT) cells. Evidence for one su... | |
medium_hidden_intermediate_01685 | Zika virus downregulates a specific gene that participates in the process 'TP53 Regulates Metabolic Genes'. Experimental data for this gene in glioma stem cells (from study GSE114907) reports a log2 fold change of -1.619 and an adjusted p-value of 0.01176. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01685","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in the process 'TP53 Regulates Metabolic Genes'. Experimental dat... | |
medium_hidden_intermediate_01687 | Two genes are structurally linked to Pegivirus C via a 'downregulates' relationship and subsequently linked to ATP binding via an 'enables' relationship. One of these genes has a reported log2 fold change of -1.142 and an adjusted p-value of 0.004405 in peripheral blood mononuclear cells. Which disease is associated wi... | alveolar rhabdomyosarcoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01687","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Pegivirus C via a 'downregulates' relationship and subsequently linked to ATP binding v... | |
medium_hidden_intermediate_01689 | A gene is downregulated by Zika virus and serves as a biomarker for gastric cancer. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -1.006 and an adjusted p-value of 0.01894. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01689","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Zika virus and serves as a biomarker for gastric cancer. Experimental data for this gene in gliom... | |
medium_hidden_intermediate_01690 | Human betaherpesvirus 5 is known to downregulate certain genes that are located in the extracellular matrix. One such gene exhibits a log2 fold change of -1.099 and an adjusted p-value of 0.0003637 in foreskin fibroblast cell lines. Which disease is associated with this specific gene? | proteinuria | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01690","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is known to downregulate certain genes that are located in the extracellular matrix. One such gene e... | |
medium_hidden_intermediate_01691 | The complement receptor 1 (CR1) is involved in a biological process that is a subclass of the negative regulation of cytokine production. Evidence for one such process states: 'Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as t... | type II interferon production | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01691","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"The complement receptor 1 (CR1) is involved in a biological process that is a subclass of the negative regulation of cytokin... | |
medium_hidden_intermediate_01693 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Asparagine N-linked glycosylation. Evidence for this gene reports a log2 fold change of 2.792 and an adjusted p-value of 0.0239. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01693","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Asparagine N-linked glyco... | |
medium_hidden_intermediate_01694 | Zika virus downregulates a specific gene that participates in Cytokine Signaling in the Immune system. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.133 and an adjusted p-value of 0.04046. Which protein is encoded by this gene? | Eukaryotic translation initiation factor 4 gamma 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01694","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in Cytokine Signaling in the Immune system. Experimental data for... | |
medium_hidden_intermediate_01695 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and is involved in post-translational protein modification. Evidence for this gene reports a log2 fold change of -1.010 and an adjusted p-value of 0.003491. Which protein is encoded by this gene? | Tubulin--tyrosine ligase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01695","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and is invol... | |
medium_hidden_intermediate_01696 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in diseases associated with N-glycosylation of proteins. Evidence for one such gene reports a log2 fold change of 1.006 and an adjusted p-value of 0.008006. Which protein is encoded by that gene? | Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01696","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in diseases associated with N-gly... | |
medium_hidden_intermediate_01697 | Measles morbillivirus upregulates a gene that participates in Membrane Trafficking. Experimental data for this gene shows a log2 fold change of 2.658 and an adjusted p-value of 0.0002177. Which biological process is this gene involved in? | mitotic cell cycle | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01697","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that participates in Membrane Trafficking. Experimental data for this gene shows a ... | |
medium_hidden_intermediate_01698 | LMNA interacts with a protein that participates in Signal Transduction. Evidence indicates that this protein is associated with Lamina-associated polypeptide (LAP) 2alpha, a binding partner of lamins A/C, which binds strongly to pocket C and weakly to pocket B. Which disease is linked to this protein as a biomarker? | prostate carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01698","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"LMNA interacts with a protein that participates in Signal Transduction. Evidence indicates that this protein is associated w... | |
medium_hidden_intermediate_01699 | A gene is upregulated by Human gammaherpesvirus 8 and enriched in basophils. Evidence for this gene reports a log2 fold change of 1.148 and an adjusted p-value of 0.01719. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01699","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human gammaherpesvirus 8 and enriched in basophils. Evidence for this gene reports a log2 fold chan... | |
medium_hidden_intermediate_01701 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a gene that participates in Mitotic Anaphase. This specific gene exhibited a log2 fold change of 6.451 and an adjusted p-value of 1.04e-08. Which protein is encoded by this gene? | Kinetochore protein Spc25 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01701","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a gene that partici... | |
medium_hidden_intermediate_01702 | In a study of Influenza A virus infection, a specific gene is downregulated by the virus and participates in protein metabolism. Evidence for this gene reports a log2 fold change of -1.557 and an adjusted p-value of 0.0008934. Which protein is encoded by this gene? | Multimerin-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01702","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is downregulated by the virus and participates in protein metabol... | |
medium_hidden_intermediate_01703 | Zika virus downregulates a specific gene, the product of which is located in a receptor complex. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -3.414 and an adjusted p-value of 0.04245. Which protein is encoded by this gene? | 5'-nucleotidase domain-containing protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01703","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, the product of which is located in a receptor complex. In a study of glioma stem c... | |
medium_hidden_intermediate_01706 | Zika virus downregulates a specific gene that subsequently interacts with RAC1. Transcriptomic data from glioma stem cells (study GSE114907) indicates that this gene has a log2 fold change of approximately -1.98 and an adjusted p-value of 0.0075. Which cellular component is this gene located in? | focal adhesion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01706","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that subsequently interacts with RAC1. Transcriptomic data from glioma stem cells (... | |
medium_hidden_intermediate_01707 | A gene is upregulated by Human gammaherpesvirus 8 and is involved in the antimicrobial humoral immune response mediated by antimicrobial peptide. Evidence for this gene in a non-Hodgkin lymphoma cell line (study GSE119608) reports a log2 fold change of approximately 3.29 and an adjusted p-value of approximately 0.045. ... | stroke disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01707","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human gammaherpesvirus 8 and is involved in the antimicrobial humoral immune response mediated by a... | |
medium_hidden_intermediate_01708 | In a study of rhabdomyosarcoma cells (GSE103308), a gene is upregulated by Enterovirus A and participates in the Hedgehog 'on' state. This specific gene exhibits a log2 fold change of approximately 1.052 and an adjusted p-value of 0.002987. Which protein does this gene interact with? | KPNA5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01708","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), a gene is upregulated by Enterovirus A and participates in the Hedgehog 'o... | |
medium_hidden_intermediate_01709 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and involved in the regulation of oxidative phosphorylation was found to have a log2 fold change of 7.312 and an adjusted p-value of 1.216e-08. Which disease is associated with this specific gene? | plasma cell myeloma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01709","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and involved in the regula... | |
medium_hidden_intermediate_01710 | In a study of cardiomyocyte cell lines, a gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in chromatin modifying enzymes. Evidence for this gene reports a log2 fold change of 1.004 and an adjusted p-value of 0.006421. Which protein is encoded by this gene? | Transcriptional adapter 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01710","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cardiomyocyte cell lines, a gene is upregulated by Severe acute respiratory syndrome-related coronavirus and p... | |
medium_hidden_intermediate_01712 | Pegivirus C is reported to downregulate a gene that participates in the 'Antigen processing: Ubiquitination & Proteasome degradation' pathway. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.069 and an adjusted p-value of 0.00189. Which protein is encoded b... | Ubiquitin-conjugating enzyme E2 K | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01712","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that participates in the 'Antigen processing: Ubiquitination & Proteasome deg... | |
medium_hidden_intermediate_01713 | A gene is downregulated by Primate bocaparvovirus 1 and participates in the Adaptive Immune System. Experimental evidence for this gene reports a log2 fold change of -1.255 and an adjusted p-value of 0.00922. Which disease is associated with this gene as a biomarker? | melanoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01713","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and participates in the Adaptive Immune System. Experimental evidence fo... | |
medium_hidden_intermediate_01714 | In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and its expression is enriched in naive CD8+ T cells. Evidence for this gene reports a log2 fold change of 1.505 and an adjusted p-value of 0.001556. Which protein is encoded by this gene? | Transmembrane protein 131 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01714","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and its expression is enriched in... | |
medium_hidden_intermediate_01716 | Two genes are downregulated by Vaccinia virus and associated with prostate cancer. One of these genes exhibits a log2 fold change of approximately -1.19 and an adjusted p-value of approximately 0.0006 in cervical adenocarcinoma cell lines. Which biological process is this specific gene involved in? | regulation of transcription by RNA polymerase II | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01716","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Vaccinia virus and associated with prostate cancer. One of these genes exhibits a log2 fold c... | |
medium_hidden_intermediate_01719 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with YWHAZ. One of these genes exhibits a log2 fold change of -1.289 and an adjusted p-value of 0.000489 in a specific study. Which protein is encoded by this gene? | Hippocalcin-like protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01719","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with YWHAZ. One of these g... | |
medium_hidden_intermediate_01720 | Human alphaherpesvirus 1 upregulates a specific gene that is located in the membrane. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of 1.278 and an adjusted p-value of 0.02937. Which disease is associated with this gene through genomic alterations? | adult medulloblastoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01720","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a specific gene that is located in the membrane. Experimental data for this gene in a m... | |
medium_hidden_intermediate_01721 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Ub-specific processing proteases. Evidence for one such gene reports a log2 fold change of 1.051 and an adjusted p-value of 0.0314. Which protein is encoded by that gene? | CAAX prenyl protease 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01721","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Ub-specific processing proteas... | |
medium_hidden_intermediate_01722 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and enriched in peripheral blood mononuclear cells. One of these genes exhibits a log2 fold change of 2.127 and an adjusted p-value of 4.474e-05 in a specific study. Which cellular component is the location of this specific gene? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01722","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and enriched in peripheral blood mononucl... | |
medium_hidden_intermediate_01723 | Two genes are upregulated by Human immunodeficiency virus 1 and participate in Phospholipid metabolism. One of these genes exhibits a log2 fold change of approximately 1.51 and an adjusted p-value of approximately 0.0077 in macrophages. Which disease is associated with this specific gene as a biomarker? | esophageal squamous cell carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01723","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and participate in Phospholipid metabolism. One of these genes e... | |
medium_hidden_intermediate_01724 | Measles morbillivirus upregulates a gene that is involved in the positive regulation of type I interferon production. Experimental data for one such gene reports a log2 fold change of 1.839 and an adjusted p-value of 0.0005406. Which protein is encoded by this gene? | Cyclic GMP-AMP synthase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01724","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is involved in the positive regulation of type I interferon production. Experi... | |
medium_hidden_intermediate_01725 | Zaire ebolavirus downregulates a gene that is located in the plasma membrane. In a study of retinal pigment epithelium cells (GSE100839), this gene exhibited a log2 fold change of -1.372 and an adjusted p-value of 0.003859. What molecular function is enabled by this gene? | G protein-coupled receptor activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01725","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus downregulates a gene that is located in the plasma membrane. In a study of retinal pigment epithelium cells... | |
medium_hidden_intermediate_01727 | Measles morbillivirus is reported to upregulate a gene that is associated with colon carcinoma. In study GSE131840, one such gene exhibits a log2 fold change of 1.135 and an adjusted p-value of 0.03151. Which protein is encoded by this specific gene? | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01727","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus is reported to upregulate a gene that is associated with colon carcinoma. In study GSE131840, one such... | |
medium_hidden_intermediate_01729 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the regulation of cell shape. Evidence for this gene reports a log2 fold change of 1.214 and an adjusted p-value of 0.003291. Which cellular component is this gene located in? | spindle pole centrosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01729","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the regulation of cell sha... | |
medium_hidden_intermediate_01730 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with COPS5. Experimental data for this gene reports a log2 fold change of approximately 1.013 and an adjusted p-value of 0.007199. Which disease is associated with this gene? | neurodevelopmental disorder with behavioral, ear, and skeletal abnormalities | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01730","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with COPS5. Experimental data f... | |
medium_hidden_intermediate_01731 | Two genes are structurally linked to Pegivirus C via downregulation and to the RAC1 GTPase cycle via participation. One of these genes exhibits a log2 fold change of -1.591 and an adjusted p-value of 0.0001748 in peripheral blood mononuclear cells (study GSE131504). Which gene is this, and what protein does it bind to? | PTK6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01731","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Pegivirus C via downregulation and to the RAC1 GTPase cycle via participation. One of t... | |
medium_hidden_intermediate_01732 | Zika virus downregulates a specific gene that is involved in the positive regulation of gene expression. Experimental data for this gene, derived from glioma stem cells, reports a log2 fold change of approximately -1.057 and an adjusted p-value of 0.03367. Which disease is associated with this gene through genomic alte... | acute coronary syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01732","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is involved in the positive regulation of gene expression. Experimental data f... | |
medium_hidden_intermediate_01733 | Zika virus downregulates a gene involved in the UDP-N-acetylglucosamine biosynthetic process. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of approximately -1.63 and an adjusted p-value of approximately 0.0105. Which cellular component is this specific gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01733","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene involved in the UDP-N-acetylglucosamine biosynthetic process. In a study of glioma stem cell... | |
medium_hidden_intermediate_01734 | Vaccinia virus upregulates a gene that is associated with leukemia. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of 4.845 and an adjusted p-value of 1.319e-07. Which protein is encoded by this gene? | Dual specificity protein phosphatase 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01734","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a gene that is associated with leukemia. Experimental data for this gene in a cervical adenocarci... | |
medium_hidden_intermediate_01735 | Human gammaherpesvirus 4 is known to downregulate a specific gene that enables protein binding. In a study of gamma delta T-lymphocytes (GSE13906), this gene exhibited a log2 fold change of approximately -2.29 and an adjusted p-value of 0.0443. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01735","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human gammaherpesvirus 4 is known to downregulate a specific gene that enables protein binding. In a study of gamma delta T-... | |
medium_hidden_intermediate_01736 | Pegivirus C is reported to downregulate a gene that is involved in lipid metabolic processes. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.572 and an adjusted p-value of 0.001097. Which protein is encoded by this specific gene? | Butyrophilin subfamily 2 member A1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01736","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in lipid metabolic processes. In a study of peripheral blood... | |
medium_hidden_intermediate_01738 | A specific gene serves as a marker for Natural killer T (NKT) cells and is associated with lymphoma. Research investigating this gene's potential as a marker for tumor cells in cutaneous lymphoma involved immunohistochemical staining of lesional skin from patch, plaque, and tumor stages. Which disease is linked to this... | breast cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01738","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A specific gene serves as a marker for Natural killer T (NKT) cells and is associated with lymphoma. Research investigating ... | |
medium_hidden_intermediate_01739 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with prostate cancer. One of these genes exhibits a log2 fold change of -1.094 and an adjusted p-value of 0.001746 in a specific study. Which cellular component is the location of this specific gene? | centrosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01739","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with prostate cancer... | |
medium_hidden_intermediate_01740 | Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to UBA52 via a binding relationship. One of these genes exhibits a log2 fold change of -1.168 and an adjusted p-value of 0.01909 in macrophages (study GSE108897). Which disease is associated with this specific gene... | Alzahrani-Kuwahara syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01740","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to UBA52 via a bin... | |
medium_hidden_intermediate_01741 | Rift Valley fever phlebovirus upregulates a gene that is located in the plasma membrane. Transcriptomic data from study GSE102481 indicates that one such gene exhibits a log2 fold change of 2.217 and an adjusted p-value of 0.02895. In which cell type is this specific gene enriched? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01741","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rift Valley fever phlebovirus upregulates a gene that is located in the plasma membrane. Transcriptomic data from study GSE1... | |
medium_hidden_intermediate_01742 | Human immunodeficiency virus 1 downregulates a gene that enables sequence-specific double-stranded DNA binding. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of approximately -3.86 and an adjusted p-value of 0.0065. Which cellular component is this gene located in? | chromosome, telomeric region | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01742","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that enables sequence-specific double-stranded DNA binding. In a study o... | |
medium_hidden_intermediate_01743 | A gene is upregulated by Primate bocaparvovirus 1 and participates in the Adaptive Immune System. Experimental data for this gene in a non-Hodgkin lymphoma cell line (study GSE119608) reports a log2 fold change of 1.051 and an adjusted p-value of 0.04417. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01743","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and participates in the Adaptive Immune System. Experimental data for this... | |
medium_hidden_intermediate_01744 | Two genes are structurally linked to Vaccinia virus via a downregulation relationship and to neuroblastoma via an association relationship. One of these genes exhibits a log2 fold change of -1.792 and an adjusted p-value of 0.006127 in a specific study. Which protein is encoded by the gene matching these statistical va... | Arginine/serine-rich coiled-coil protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01744","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Vaccinia virus via a downregulation relationship and to neuroblastoma via an associatio... | |
medium_hidden_intermediate_01747 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in the positive regulation of DNA-templated transcription. Experimental evidence for this gene shows a log2 fold change of approximately -1.50 and an adjusted p-value of approximately 0.032. Which protein interacts with this gen... | NR1D2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01747","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in the positive regulation of DN... | |
medium_hidden_intermediate_01748 | Two genes are structurally linked to Pegivirus C via downregulation and to PEX5 via binding. One of these genes exhibits a log2 fold change of -1.795 and an adjusted p-value of 9.429e-05 in peripheral blood mononuclear cells. Which disease is associated with this specific gene? | rhizomelic chondrodysplasia punctata type 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01748","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Pegivirus C via downregulation and to PEX5 via binding. One of these genes exhibits a l... | |
medium_hidden_intermediate_01750 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables chromatin binding. Evidence for this gene in a specific study reports a log2 fold change of -1.866 and an adjusted p-value of 0.004699. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01750","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables chromatin binding. Evidence for... | |
medium_hidden_intermediate_01753 | A gene is upregulated by Measles morbillivirus and participates in Reproduction. Experimental data for this gene in pleural mesothelioma cells (study GSE117668) reports a log2 fold change of 1.827 and an adjusted p-value of 0.003535. Which cell type is this gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01753","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and participates in Reproduction. Experimental data for this gene in pleural ... | |
medium_hidden_intermediate_01754 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 downregulates a specific gene, which in turn interacts with VASP. Evidence for this gene shows a log2 fold change of approximately -1.33 and an adjusted p-value of 0.0063. Which protein is encoded by this gene? | NHS-like protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01754","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 downregulates a specific gene, which in turn interacts... | |
medium_hidden_intermediate_01756 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and interacts with YWHAE. Evidence for this gene reports a log2 fold change of -1.073 and an adjusted p-value of 0.01829. Which biological process is this gene involved in? | basement membrane organization | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01756","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and interacts with YWHAE. Evidence for this... | |
medium_hidden_intermediate_01757 | Rift Valley fever phlebovirus upregulates a gene that is enriched in neutrophils. One such gene exhibits a log2 fold change of 3.149 and an adjusted p-value of 0.000496 in SAEC cells (study GSE102481). Which biological process is this gene involved in? | positive regulation of transcription by RNA polymerase II | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01757","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rift Valley fever phlebovirus upregulates a gene that is enriched in neutrophils. One such gene exhibits a log2 fold change ... | |
medium_hidden_intermediate_01758 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a gene that enables glycerophospholipase activity. One such gene exhibited a log2 fold change of approximately 1.196 and an adjusted p-value of 0.01661. Which protein is encoded by this specific gene? | Acyl-protein thioesterase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01758","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a gene that enables glycer... | |
medium_hidden_intermediate_01759 | Enterovirus A upregulates a gene that participates in phospholipid metabolism. In a study of rhabdomyosarcoma cells (GSE103308), one such gene showed a log2 fold change of 1.619 and an adjusted p-value of 0.01884. Which disease is associated with genomic alterations in this specific gene? | seminoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01759","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A upregulates a gene that participates in phospholipid metabolism. In a study of rhabdomyosarcoma cells (GSE1033... | |
medium_hidden_intermediate_01761 | In a study of monocytic leukemia cells (GSE114966), Human alphaherpesvirus 1 upregulates a specific gene that participates in RNA Polymerase II transcription. This gene exhibits a log2 fold change of approximately 1.856 and an adjusted p-value of 0.009823. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01761","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of monocytic leukemia cells (GSE114966), Human alphaherpesvirus 1 upregulates a specific gene that participates i... | |
medium_hidden_intermediate_01763 | In a study of Influenza A virus infection, a specific gene is upregulated by the virus and participates in cellular responses to stimuli. Evidence for this gene reports a log2 fold change of approximately 1.31 and an adjusted p-value of approximately 0.0104. Which protein is encoded by this gene? | Glutathione-specific gamma-glutamylcyclotransferase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01763","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is upregulated by the virus and participates in cellular response... | |
medium_hidden_intermediate_01764 | Hydrocortisone and Deflazacort are both known to interact with a specific intermediate drug. Evidence regarding this intermediate drug states: 'Systemic steroids are commonly used to manage immune-related adverse events (irAEs), but it remains unclear whether they may undermine immune checkpoint inhibitor (ICI) therapy... | colorectal cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01764","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hydrocortisone and Deflazacort are both known to interact with a specific intermediate drug. Evidence regarding this interme... | |
medium_hidden_intermediate_01765 | Hepacivirus C upregulates a gene that is involved in the negative regulation of transcription by RNA polymerase II. Experimental data from a study on hepatocytes (GSE132606) indicates that this gene has a log2 fold change of approximately 1.75 and an adjusted p-value of approximately 0.011. Which protein is encoded by ... | THAP domain-containing protein 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01765","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in the negative regulation of transcription by RNA polymerase II. Experime... | |
medium_hidden_intermediate_01767 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that enables signaling receptor binding. Experimental data for this gene in choroid plexus epithelium shows a log2 fold change of approximately -1.15 and an adjusted p-value of approximately 1.34e-05. Which protein is encoded by this gene? | Leptin receptor gene-related protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01767","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that enables signaling receptor binding. Experime... | |
medium_hidden_intermediate_01769 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables DNA-binding transcription activator activity, RNA polymerase II-specific. Evidence for this gene reports a log2 fold change of 2.786 and an adjusted p-value of 0.0188. Which disease is associated with this gene? | lip and oral cavity carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01769","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables DNA-binding transcription activat... | |
medium_hidden_intermediate_01770 | Pegivirus C is reported to downregulate a specific gene, which is subsequently involved in the maturation of SSU-rRNA. Experimental data from a study on peripheral blood mononuclear cells (GSE131504) indicates that this gene exhibits a log2 fold change of approximately -1.35 and an adjusted p-value of 0.00177. Which pr... | DDB1- and CUL4-associated factor 13 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01770","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which is subsequently involved in the maturation of SSU-rRNA. Exper... | |
medium_hidden_intermediate_01771 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with CEP290. Experimental data for this gene reports a log2 fold change of 2.233 and an adjusted p-value of 0.03556. Which protein is encoded by this gene? | Paraneoplastic antigen Ma2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01771","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with CEP290. Experimental data ... | |
medium_hidden_intermediate_01772 | Enterovirus A is reported to downregulate a specific gene, which is subsequently involved in plasma membrane phospholipid scrambling. In a study of rhabdomyosarcoma cells (GSE103308), this gene exhibited a log2 fold change of approximately -2.006 and an adjusted p-value of 0.01276. Which disease is associated with this... | schizophrenia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01772","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is reported to downregulate a specific gene, which is subsequently involved in plasma membrane phospholipid sc... | |
medium_hidden_intermediate_01776 | In a study of monocytic leukemia cells infected with Human alphaherpesvirus 1, a specific gene is upregulated by the virus and participates in metabolism. This gene exhibits a log2 fold change of approximately 1.90 and an adjusted p-value of 0.0186. What molecular function is enabled by this gene? | arsenite methyltransferase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01776","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of monocytic leukemia cells infected with Human alphaherpesvirus 1, a specific gene is upregulated by the virus a... | |
medium_hidden_intermediate_01777 | Measles morbillivirus upregulates a gene that interacts with SFXN1. Evidence for one such gene reports a log2 fold change of 4.480 and an adjusted p-value of 0.04104. Which protein is encoded by that gene? | Mitochondrial adenyl nucleotide antiporter SLC25A25 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01777","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that interacts with SFXN1. Evidence for one such gene reports a log2 fold change of... | |
medium_hidden_intermediate_01778 | In a study of peripheral blood mononuclear cells (GSE131504), a gene is identified as being downregulated by Pegivirus C and interacting with CDC42. This specific gene exhibits a log2 fold change of -1.169 and an adjusted p-value of 0.007122. Which protein is encoded by this gene? | CDC42 small effector protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01778","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of peripheral blood mononuclear cells (GSE131504), a gene is identified as being downregulated by Pegivirus C and... | |
medium_hidden_intermediate_01779 | Human betaherpesvirus 5 is known to downregulate certain genes whose products are located in the mitochondrial membrane. One such gene exhibits a log2 fold change of -1.239 and an adjusted p-value of 0.003381 in a specific study. Which protein is encoded by this gene? | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01779","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is known to downregulate certain genes whose products are located in the mitochondrial membrane. One... | |
medium_hidden_intermediate_01780 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in chromosome segregation. Experimental data for this gene reports a log2 fold change of -1.130 and an adjusted p-value of 0.04022. Which protein is encoded by this gene? | Cilia- and flagella-associated protein 100 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01780","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in chromosome segregation. ... | |
medium_hidden_intermediate_01782 | Measles morbillivirus upregulates a gene that interacts with RAB11A. In study GSE131840, one such gene exhibits a log2 fold change of 1.674 and an adjusted p-value of 0.01838. Which disease is associated with this specific gene? | colitis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01782","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that interacts with RAB11A. In study GSE131840, one such gene exhibits a log2 fold ... | |
medium_hidden_intermediate_01783 | A gene is upregulated by Human gammaherpesvirus 8 and enriched in non-classical monocytes. Evidence for this gene in a non-Hodgkin lymphoma cell line (study GSE119608) reports a log2 fold change of 1.115 and an adjusted p-value of 0.03884. Which biological process is this gene involved in? | regulation of autophagy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01783","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human gammaherpesvirus 8 and enriched in non-classical monocytes. Evidence for this gene in a non-H... | |
medium_hidden_intermediate_01784 | Zika virus downregulates a gene that is involved in the carbohydrate metabolic process. Evidence for this specific gene reports a log2 fold change of -1.213 and an adjusted p-value of 0.0203. Which protein is encoded by this gene? | N-acetylgalactosaminyltransferase 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01784","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the carbohydrate metabolic process. Evidence for this specific gene repo... | |
medium_hidden_intermediate_01786 | In a study of lung cells, a gene upregulated by Severe acute respiratory syndrome-related coronavirus and located in the ciliary basal body showed a log2 fold change of approximately 1.266 and an adjusted p-value of 0.007286. Which protein is encoded by this gene? | Afadin- and alpha-actinin-binding protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01786","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells, a gene upregulated by Severe acute respiratory syndrome-related coronavirus and located in the cil... | |
medium_hidden_intermediate_01787 | Hepacivirus C is known to downregulate a specific gene, which in turn participates in a disease process. Experimental data for this gene reports a log2 fold change of -2.244 and an adjusted p-value of 0.002325. Which disease is associated with this gene as a biomarker? | alcohol abuse | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01787","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is known to downregulate a specific gene, which in turn participates in a disease process. Experimental data f... | |
medium_hidden_intermediate_01788 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and to UBE2M via a 'binds' relationship. One of these genes is associated with experimental data showing a log2 fold change of 1.335 and an adjusted p-value of 0.02302. Which protein is encoded b... | Kelch-like protein 21 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01788","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship... | |
medium_hidden_intermediate_01790 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is downregulated by Vaccinia virus and participates in the RHO GTPase cycle. Evidence for this specific gene reports a log2 fold change of approximately -1.33 and an adjusted p-value of 0.0083. Which protein is encoded by this gene? | Protein FAM91A1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01790","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is downregulated by Vaccinia virus and participates in t... | |
medium_hidden_intermediate_01791 | Two genes are downregulated by Human immunodeficiency virus 1 and are associated with adenoviridae infectious disease. One of these genes exhibits a log2 fold change of -1.850 and an adjusted p-value of 0.01566 in macrophages (study GSE108897). Which disease is protected against by this specific gene? | retinal degeneration | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01791","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Human immunodeficiency virus 1 and are associated with adenoviridae infectious disease. One o... | |
medium_hidden_intermediate_01792 | Hepacivirus C upregulates a gene that is involved in the regulation of blood pressure. Evidence for one such gene reports a log2 fold change of 3.442 and an adjusted p-value of 0.0226. Which protein is encoded by that gene? | Epithelial sodium channel subunit delta | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01792","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in the regulation of blood pressure. Evidence for one such gene reports a ... | |
medium_hidden_intermediate_01793 | Zika virus downregulates a specific gene, which in turn interacts with GABARAPL1. Experimental data for this gene reports a log2 fold change of -1.011 and an adjusted p-value of 0.01136. Which protein is encoded by this gene? | Rab GTPase-activating protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01793","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with GABARAPL1. Experimental data for this gene reports a ... | |
medium_hidden_intermediate_01795 | Pegivirus C is reported to downregulate a specific gene that participates in cellular responses to stress. Transcriptomic data for this gene indicates a log2 fold change of -1.142 and an adjusted p-value of 0.004405. In which cell type is this gene enriched? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01795","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene that participates in cellular responses to stress. Transcriptomic da... | |
medium_hidden_intermediate_01796 | In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and is involved in angiogenesis. This gene exhibits a log2 fold change of 1.507 and an adjusted p-value of 0.008117. Which protein is encoded by this gene? | Homeobox protein Hox-B3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01796","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and is involved in angiogenesis. ... | |
medium_hidden_intermediate_01797 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene involved in Rab regulation of trafficking. This gene exhibited a log2 fold change of approximately 5.375 and an adjusted p-value of 2.18e-05. Which protein is encoded by this gene? | Ras-related protein Rab-38 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01797","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_01799 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with endometrial carcinoma. One of these genes exhibits a log2 fold change of 1.857 and an adjusted p-value of 7.536e-06 in monocytes (study GSE160351). Which disease is linked to this specific gene through genomic alt... | pituitary gigantism | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01799","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with endometrial carci... | |
medium_hidden_intermediate_01801 | Hepacivirus C is linked to CCNA1 via an intermediate gene through a downregulation followed by a protein-protein interaction. One such intermediate gene exhibits a log2 fold change of -1.378 and an adjusted p-value of 0.005131 in peripheral blood mononuclear cells. Which biological process is this intermediate gene inv... | negative regulation of cyclin-dependent protein serine/threonine kinase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01801","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is linked to CCNA1 via an intermediate gene through a downregulation followed by a protein-protein interaction... | |
medium_hidden_intermediate_01802 | Zika virus upregulates a gene that enables protein kinase activity. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of 5.185 and an adjusted p-value of 0.03921. Which protein is encoded by this gene? | Ribosomal protein S6 kinase-like 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01802","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that enables protein kinase activity. Experimental data for this gene in glioma stem cells (st... | |
medium_hidden_intermediate_01803 | Human betaherpesvirus 5 downregulates a gene that is involved in the positive regulation of transcription by RNA polymerase II. Evidence for this gene shows a log2 fold change of approximately -1.235 and an adjusted p-value of 0.002012. Which cellular component is this gene located in? | transcription regulator complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01803","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 downregulates a gene that is involved in the positive regulation of transcription by RNA polymerase ... | |
medium_hidden_intermediate_01805 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the inflammatory response. Evidence for one such gene reports a log2 fold change of 1.250 and an adjusted p-value of 0.0002166. Which molecular function is enabled by that gene? | carbohydrate binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01805","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the inflammatory response. Evid... | |
medium_hidden_intermediate_01806 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is located in the lysosomal membrane. Evidence for this gene reports a log2 fold change of 3.162 and an adjusted p-value of 0.01021. Which disease is associated with this gene? | amyloidosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01806","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is located in the lysosomal membrane. Evi... | |
medium_hidden_intermediate_01807 | A specific genetic variant, NM_015600.4(ABHD12):c.-6898_191+7002delinsCC, is linked to a gene that interacts with SQSTM1. Experimental evidence indicates that the protein product of this gene directly interacts with p62, as demonstrated by in vitro pulldown assays. Which protein is encoded by this gene? | Apoptosis regulator Bcl-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01807","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A specific genetic variant, NM_015600.4(ABHD12):c.-6898_191+7002delinsCC, is linked to a gene that interacts with SQSTM1. Ex... | |
medium_hidden_intermediate_01808 | A gene is upregulated by Vaccinia virus and serves as a biomarker for breast carcinoma. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of 1.562 and an adjusted p-value of 0.02943. Which protein is encoded by this gene? | Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01808","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Vaccinia virus and serves as a biomarker for breast carcinoma. Experimental data for this gene in a... | |
medium_hidden_intermediate_01809 | Zika virus downregulates a specific gene that participates in the Toll Like Receptor 5 (TLR5) Cascade. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -1.18 and an adjusted p-value of 0.024. Which biological process is this gene involved in? | response to X-ray | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01809","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in the Toll Like Receptor 5 (TLR5) Cascade. In a study of glioma ... | |
medium_hidden_intermediate_01810 | In a study of lung cells (GSE148697), Severe acute respiratory syndrome-related coronavirus was found to downregulate a specific gene, which in turn encodes a protein that binds to Talin-1 (TLN1). One such gene exhibited a log2 fold change of approximately -1.40 and an adjusted p-value of 0.008. Which protein is encode... | Amyloid beta A4 precursor protein-binding family B member 1-interacting protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01810","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells (GSE148697), Severe acute respiratory syndrome-related coronavirus was found to downregulate a spec... | |
medium_hidden_intermediate_01811 | Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to cognition via an 'involved in' relationship. One of these genes is associated with a log2 fold change of -1.326 and an adjusted p-value of 0.03019 in a specific study context. Which cell type is enriched in the... | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01811","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to cognition via ... | |
medium_hidden_intermediate_01812 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes involved in the proteasome-mediated ubiquitin-dependent protein catabolic process. One such gene exhibited a log2 fold change of approximately 1.029 and an adjusted p-value of 0.002562. Which prot... | Adapter SH3BGRL | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01812","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes ... | |
medium_hidden_intermediate_01813 | Cardiovirus A downregulates a gene that interacts with MATR3. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of approximately -1.56 and an adjusted p-value of 0.043. Which protein is encoded by this gene? | Polypyrimidine tract-binding protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01813","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A downregulates a gene that interacts with MATR3. Experimental data for this gene in a cervical adenocarcinoma c... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.