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medium_hidden_intermediate_01814 | Human betaherpesvirus 5 is linked to benign neoplasm via a gene that it downregulates and which is associated with the condition. One such gene exhibits a log2 fold change of -3.318 and an adjusted p-value of 0.03848 in foreskin fibroblast cell lines. Which protein is encoded by this specific gene? | Keratin, type II cytoskeletal 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01814","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is linked to benign neoplasm via a gene that it downregulates and which is associated with the condi... | |
medium_hidden_intermediate_01815 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and serves as a biomarker for schizophrenia. Experimental data for this gene reports a log2 fold change of approximately 1.124 and an adjusted p-value of 0.01076. Which protein is encoded by this gene? | Neuronal PAS domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01815","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and serves as a biomarker for schizophrenia. ... | |
medium_hidden_intermediate_01816 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the antimicrobial mechanism of IFN-stimulated genes. Experimental data for this gene reports a log2 fold change of 7.123 and an adjusted p-value of 0.0002039. In which cell type is this gene enriched? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01816","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the antimicrobial mechani... | |
medium_hidden_intermediate_01817 | Zika virus downregulates a gene that participates in SLC-mediated transmembrane transport. In a study of glioma stem cells (GSE114907), one such gene showed a log2 fold change of -2.305 and an adjusted p-value of 0.01461. Which disease is associated with this specific gene? | 5p partial monosomy syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01817","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in SLC-mediated transmembrane transport. In a study of glioma stem cells (... | |
medium_hidden_intermediate_01818 | Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to UBA52 via a binding relationship. One of these genes exhibits a log2 fold change of approximately -1.51 and an adjusted p-value of 0.001489 in macrophages (study GSE108897). Which disease is associated with this... | preeclampsia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01818","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to UBA52 via a bin... | |
medium_hidden_intermediate_01820 | Pegivirus C is reported to downregulate a gene that is located in the midbody. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -2.207 and an adjusted p-value of 0.00759. Which protein is encoded by this specific gene? | Spartin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01820","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is located in the midbody. In a study of peripheral blood mononuclear ce... | |
medium_hidden_intermediate_01821 | Measles morbillivirus upregulates a gene that interacts with HIST1H2BG. Evidence for one such gene reports a log2 fold change of 1.034 and an adjusted p-value of 0.001018. Which disease is associated with that gene? | carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01821","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that interacts with HIST1H2BG. Evidence for one such gene reports a log2 fold chang... | |
medium_hidden_intermediate_01823 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a gene that interacts with SFXN1. One such gene exhibits a log2 fold change of approximately 1.835 and an adjusted p-value of 0.0001239. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01823","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a gene that interacts with SFXN1. On... | |
medium_hidden_intermediate_01825 | A gene associated with Innate lymphoid cells via a marker relationship and linked to identical protein binding via an enables relationship is the subject of the following evidence: 'The protein, which exists as a disulfide-linked homodimer on the cell surface, crystallizes as a symmetrical dimer.' Which disease is conn... | vitiligo | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01825","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene associated with Innate lymphoid cells via a marker relationship and linked to identical protein binding via an enable... | |
medium_hidden_intermediate_01828 | Two genes are downregulated by Human immunodeficiency virus 1 and participate in O-linked glycosylation of mucins. One of these genes exhibits a log2 fold change of -1.726 and an adjusted p-value of 0.003843 in macrophages (study GSE108897). Which disease is associated with genomic alterations in this specific gene? | colorectal carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01828","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Human immunodeficiency virus 1 and participate in O-linked glycosylation of mucins. One of th... | |
medium_hidden_intermediate_01829 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to bone osteosarcoma via a biomarker relationship. One of these genes is associated with a log2 fold change of approximately 2.697 and an adjusted p-value of 0.04321. Which protein is encoded by this speci... | Homeobox protein Hox-A5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01829","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to bone o... | |
medium_hidden_intermediate_01830 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables ATPase activator activity. Transcriptomic data for this gene in choroid plexus epithelium shows a log2 fold change of approximately 1.017 and an adjusted p-value of 0.0006068. Which cellular component is this gene located in? | membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01830","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables ATPase activator activity. Transc... | |
medium_hidden_intermediate_01831 | Human alphaherpesvirus 3 upregulates a gene that is located in the lysosome. Evidence for one such gene reports a log2 fold change of 1.526 and an adjusted p-value of 4.326e-06. Which biological process is this gene involved in? | negative regulation of antigen processing and presentation of peptide antigen via MHC class II | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01831","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 upregulates a gene that is located in the lysosome. Evidence for one such gene reports a log2 fold ... | |
medium_hidden_intermediate_01832 | Pegivirus C is reported to downregulate a gene that is involved in protein dephosphorylation. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.335 and an adjusted p-value of 0.0002127. Which protein is encoded by this specific gene? | Tyrosine-protein phosphatase non-receptor type 18 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01832","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in protein dephosphorylation. In a study of peripheral blood... | |
medium_hidden_intermediate_01837 | Zika virus downregulates a specific gene that is enriched in naive CD4+ T cells. Transcriptomic data from glioma stem cells (study GSE114907) indicates this gene has a log2 fold change of -2.334 and an adjusted p-value of 0.003481. What molecular function is enabled by this gene? | 3',5'-cyclic-AMP phosphodiesterase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01837","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is enriched in naive CD4+ T cells. Transcriptomic data from glioma stem cells ... | |
medium_hidden_intermediate_01838 | Pegivirus C is reported to downregulate a gene that participates in iron uptake and transport. Evidence for one such gene shows a log2 fold change of -1.783 and an adjusted p-value of 0.01062. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01838","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that participates in iron uptake and transport. Evidence for one such gene sh... | |
medium_hidden_intermediate_01840 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables ubiquitin-modified protein reader activity. Experimental data for this gene reports a log2 fold change of -1.624 and an adjusted p-value of 0.03115. Which protein is encoded by this gene? | Ankyrin repeat domain-containing protein 13A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01840","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables ubiquitin-modified protein read... | |
medium_hidden_intermediate_01841 | In a study of glioma stem cells (GSE114907), Zika virus infection was found to downregulate a specific gene, which is associated with amenorrhea. This gene exhibited a log2 fold change of -1.972 and an adjusted p-value of 0.0086. Which protein is encoded by this gene? | 5-hydroxytryptamine receptor 1D | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01841","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), Zika virus infection was found to downregulate a specific gene, which is associ... | |
medium_hidden_intermediate_01842 | In a study of choroid plexus epithelium (GSE157852), a gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with DDX39B. This gene exhibits a log2 fold change of 4.099 and an adjusted p-value of 0.007046. Which protein is encoded by this gene? | Mitotic interactor and substrate of PLK1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01842","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), a gene is upregulated by Severe acute respiratory syndrome-related coro... | |
medium_hidden_intermediate_01843 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in nervous system development. Evidence for this gene reports a log2 fold change of -1.016 and an adjusted p-value of 0.0411. Which disease is associated with this gene as a biomarker? | Alzheimer disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01843","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in nervous system developme... | |
medium_hidden_intermediate_01844 | In a study of Influenza A virus infection, a specific gene is downregulated and serves as a biomarker for gastric cancer. Evidence for this gene reports a log2 fold change of -1.026 and an adjusted p-value of 0.0005101. Which protein is encoded by this gene? | Discoidin, CUB and LCCL domain-containing protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01844","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is downregulated and serves as a biomarker for gastric cancer. Ev... | |
medium_hidden_intermediate_01846 | Two genes serve as markers for Oocytes and are also enriched in Naive CD8+ T cells. One of these genes exhibits a mean expression of 14.14 TPM, a z-score of 1.78, and a fold enrichment of 3.37 in immune cell RNA-seq data. Which biological process is associated with this specific gene? | collagen biosynthetic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01846","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes serve as markers for Oocytes and are also enriched in Naive CD8+ T cells. One of these genes exhibits a mean expre... | |
medium_hidden_intermediate_01847 | Zika virus upregulates a gene that participates in the transport of small molecules. Experimental data for this gene reports a log2 fold change of 2.123 and an adjusted p-value of 0.008868. In which cell type is this gene enriched? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01847","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that participates in the transport of small molecules. Experimental data for this gene reports... | |
medium_hidden_intermediate_01848 | In a study of cardiomyocyte cell lines, a gene upregulated by Severe acute respiratory syndrome-related coronavirus and located in the GABA-A receptor complex showed a log2 fold change of approximately 2.39 and an adjusted p-value of 0.0064. Which protein is encoded by this gene? | Gamma-aminobutyric acid receptor subunit epsilon | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01848","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cardiomyocyte cell lines, a gene upregulated by Severe acute respiratory syndrome-related coronavirus and loca... | |
medium_hidden_intermediate_01849 | In a study of Measles morbillivirus infection, a specific gene is downregulated by the virus and its product binds to MT-ATP8. Evidence for this gene reports a log2 fold change of -1.082 and an adjusted p-value of 0.0006792. Which protein is encoded by this gene? | ATP synthase F(0) complex subunit C1, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01849","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is downregulated by the virus and its product binds to MT-ATP... | |
medium_hidden_intermediate_01850 | Human immunodeficiency virus 1 upregulates a gene that is associated with lung carcinoma. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of 2.028 and an adjusted p-value of 0.0009264. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01850","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is associated with lung carcinoma. Evidence for this gene in macropha... | |
medium_hidden_intermediate_01851 | Human alphaherpesvirus 3 is reported to upregulate a gene that is enriched in Mucosa-associated invariant T (MAIT) cells. Evidence for this specific gene in a melanoma cell line (study GSE136586) shows a log2 fold change of approximately 1.88 and an adjusted p-value of 4.928e-07. Which protein is encoded by this gene? | GTPase RhebL1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01851","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 is reported to upregulate a gene that is enriched in Mucosa-associated invariant T (MAIT) cells. Ev... | |
medium_hidden_intermediate_01853 | Two genes are structurally linked to gastritis via an 'associated with' relationship, originating from different cell types: one from Oogenesis phase fetal germ cells and the other from Oligodendrocyte progenitor cells. Evidence indicates that in non-neoplastic inflammation, such as gastritis, the protein product of on... | thyroid tumor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01853","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to gastritis via an 'associated with' relationship, originating from different cell types:... | |
medium_hidden_intermediate_01854 | Human betaherpesvirus 5 upregulates a gene that binds to UBC. Experimental data for this gene in a retinal pigment epithelium cell line (study GSE120891) reports a log2 fold change of 1.771 and an adjusted p-value of 0.007209. Which gene interacts with the entity identified by these statistics? | USP3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01854","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that binds to UBC. Experimental data for this gene in a retinal pigment epitheliu... | |
medium_hidden_intermediate_01855 | A gene is upregulated by Primate bocaparvovirus 1 and located in the extracellular space. Evidence for this gene reports a log2 fold change of 2.638 and an adjusted p-value of 0.03615. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01855","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and located in the extracellular space. Evidence for this gene reports a l... | |
medium_hidden_intermediate_01856 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the synthesis of PA. Evidence for this gene reports a log2 fold change of 1.096 and an adjusted p-value of 0.01148. Which protein is encoded by this gene? | Mitoguardin 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01856","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the synthesis of PA. Evidence ... | |
medium_hidden_intermediate_01857 | Zika virus downregulates a specific gene, which in turn binds to TFDP1. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -1.792 and an adjusted p-value of 0.02284. Which protein is encoded by this gene? | Protein lin-9 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01857","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn binds to TFDP1. Experimental data for this gene in glioma stem cells... | |
medium_hidden_intermediate_01858 | In a study of lung cells (GSE148697), a gene is identified as being downregulated by Severe acute respiratory syndrome-related coronavirus and interacting with ACE2. This specific gene exhibits a log2 fold change of approximately -4.02 and an adjusted p-value of approximately 0.00043. Which disease is associated with t... | gastric cardia adenocarcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01858","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells (GSE148697), a gene is identified as being downregulated by Severe acute respiratory syndrome-relat... | |
medium_hidden_intermediate_01859 | A gene is upregulated by Primate bocaparvovirus 1 and is located in the plasma membrane. Experimental evidence for this gene reports a log2 fold change of 1.143 and an adjusted p-value of 0.04941. Which cell type is this gene enriched in? | mucosal-associated invariant T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01859","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and is located in the plasma membrane. Experimental evidence for this gene... | |
medium_hidden_intermediate_01860 | Two genes are upregulated by Vaccinia virus and interact with DYNLL1. One of these genes exhibits a log2 fold change of 2.574 and an adjusted p-value of 1.003e-08 in cervical adenocarcinoma cell lines. Which cell type is enriched for this specific gene? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01860","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and interact with DYNLL1. One of these genes exhibits a log2 fold change of 2.57... | |
medium_hidden_intermediate_01861 | Zika virus downregulates a gene that participates in the CDC42 GTPase cycle. In glioma stem cells, one such gene exhibits a log2 fold change of -4.453 and an adjusted p-value of 0.02783. Which molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01861","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in the CDC42 GTPase cycle. In glioma stem cells, one such gene exhibits a ... | |
medium_hidden_intermediate_01862 | Zika virus upregulates a gene that is involved in the inflammatory response. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of approximately 5.81 and an adjusted p-value of 0.0076. Which protein is encoded by this specific gene? | Interleukin-13 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01862","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that is involved in the inflammatory response. In a study of glioma stem cells (GSE114907), on... | |
medium_hidden_intermediate_01864 | A gene is downregulated by Zika virus and enables protein heterodimerization activity. Transcriptomic data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -2.701 and an adjusted p-value of 0.01552. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01864","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Zika virus and enables protein heterodimerization activity. Transcriptomic data for this gene in ... | |
medium_hidden_intermediate_01865 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the downregulation of a specific gene, which in turn binds to the YY1 protein. This gene exhibits a log2 fold change of approximately -1.93 and an adjusted p-value of 8.875e-05. Which protein is encoded by this gene? | INO80 complex subunit D | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01865","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_01867 | Human alphaherpesvirus 1 upregulates a gene that encodes a protein binding to SMC4. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of 2.106 and an adjusted p-value of 0.01216. Which protein is encoded by this gene? | Condensin-2 complex subunit D3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01867","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that encodes a protein binding to SMC4. Experimental data for this gene in a mon... | |
medium_hidden_intermediate_01869 | Influenza A virus upregulates a gene that participates in the RAC1 GTPase cycle. Evidence for this gene reports a log2 fold change of 1.411 and an adjusted p-value of 3.032e-09. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01869","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Influenza A virus upregulates a gene that participates in the RAC1 GTPase cycle. Evidence for this gene reports a log2 fold ... | |
medium_hidden_intermediate_01871 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to SYVN1 via an 'interacts with' relationship. One of these genes has been reported in a study (GSE164073) with a log2 fold change of approximately -1.583 and an adjusted p-value of 0.001346... | plasma cell myeloma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01871","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_01872 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Diseases of metabolism. Evidence for this gene reports a log2 fold change of 1.045 and an adjusted p-value of 0.001447. Which protein is encoded by this gene? | L-xylulose reductase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01872","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Diseases of metabolism. E... | |
medium_hidden_intermediate_01873 | Omeprazole interacts with a specific drug, which in turn interacts with Magaldrate. Clinical evidence indicates that the plasma concentration of this intermediate drug increases when coadministered with omeprazole in healthy subjects, a phenomenon likely driven by increased bioavailability due to elevated gastric pH. W... | HIV infectious disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01873","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Omeprazole interacts with a specific drug, which in turn interacts with Magaldrate. Clinical evidence indicates that the pla... | |
medium_hidden_intermediate_01874 | Human immunodeficiency virus 1 downregulates a gene that is involved in the negative regulation of canonical NF-kappaB signal transduction. Evidence for this gene reports a log2 fold change of -1.273 and an adjusted p-value of 0.02467. Which protein is encoded by this gene? | Tripartite motif-containing protein 59 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01874","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is involved in the negative regulation of canonical NF-kappaB signa... | |
medium_hidden_intermediate_01875 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of certain genes involved in the positive regulation of the MAPK cascade. One such gene exhibits a log2 fold change of approximately 2.156 and an adjusted p-value of 0.0127. Which protein is encoded by this specific gene... | Interleukin-11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01875","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of certain genes involve... | |
medium_hidden_intermediate_01876 | Enterovirus A upregulates a gene that is involved in spermatogenesis. In a study of rhabdomyosarcoma cells (GSE103308), one such gene showed a log2 fold change of 2.657 and an adjusted p-value of 0.01268. Which protein is encoded by this gene? | Testis development-related protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01876","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A upregulates a gene that is involved in spermatogenesis. In a study of rhabdomyosarcoma cells (GSE103308), one ... | |
medium_hidden_intermediate_01877 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Interferon gamma signaling. Evidence for this gene reports a log2 fold change of -1.223 and an adjusted p-value of 0.02865. Which protein is encoded by this gene? | E3 ubiquitin-protein ligase TRIM34 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01877","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Interferon gamma signal... | |
medium_hidden_intermediate_01878 | In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and is involved in the immune response. This specific gene exhibits a log2 fold change of approximately 1.088 and an adjusted p-value of 0.03791. Which protein is encoded by this gene? | Interferon alpha-inducible protein 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01878","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and is involved... | |
medium_hidden_intermediate_01879 | Zika virus downregulates a gene that is associated with aneuploidy. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of approximately -1.41 and an adjusted p-value of 0.0193. Which protein is encoded by this specific gene? | Ras association domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01879","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is associated with aneuploidy. In a study of glioma stem cells (GSE114907), one such ge... | |
medium_hidden_intermediate_01880 | Human alphaherpesvirus 3 is known to downregulate a specific gene that enables protein binding. In a study (GSE136586) involving melanoma cell lines, this gene exhibited a log2 fold change of -1.367 and an adjusted p-value of 0.0002459. Which cell type is this gene enriched in? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01880","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 is known to downregulate a specific gene that enables protein binding. In a study (GSE136586) invol... | |
medium_hidden_intermediate_01884 | A gene is downregulated by Zika virus and is involved in mRNA splicing via the spliceosome. Evidence for this gene in glioma stem cells reports a log2 fold change of -1.551 and an adjusted p-value of 0.01373. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01884","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Zika virus and is involved in mRNA splicing via the spliceosome. Evidence for this gene in glioma... | |
medium_hidden_intermediate_01886 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of specific genes that participate in 'Signaling by Rho GTPases, Miro GTPases and RHOBTB3'. One such gene exhibits a log2 fold change of approximately -1.84 and an adjusted p-value of approximately 0.0139. ... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01886","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of specifi... | |
medium_hidden_intermediate_01887 | CUL2 interacts with a protein that participates in the proteasome-mediated ubiquitin-dependent protein catabolic process. Evidence indicates that the VHL-Elongin BC complex interacts with a module composed of Cullin family member Cul2 and RING-H2 finger protein Rbx1 to reconstitute a novel E3 ubiquitin ligase. Which pr... | Elongin-B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01887","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"CUL2 interacts with a protein that participates in the proteasome-mediated ubiquitin-dependent protein catabolic process. Ev... | |
medium_hidden_intermediate_01888 | Enterovirus A is reported to downregulate a gene that is located in cell-cell junctions. In a study of rhabdomyosarcoma cells (GSE103308), one such gene exhibited a log2 fold change of approximately -1.069 and an adjusted p-value of 0.02996. Which protein is encoded by this specific gene? | Protocadherin Fat 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01888","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is reported to downregulate a gene that is located in cell-cell junctions. In a study of rhabdomyosarcoma cell... | |
medium_hidden_intermediate_01889 | Human betaherpesvirus 5 is reported to upregulate a gene that is involved in the positive regulation of the ERK1 and ERK2 cascade. Experimental data from a study on foreskin fibroblast cell lines (GSE132081) indicates that this specific gene exhibits a log2 fold change of approximately 6.606 and an adjusted p-value of ... | Interleukin-13 receptor subunit alpha-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01889","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to upregulate a gene that is involved in the positive regulation of the ERK1 and ERK2 ca... | |
medium_hidden_intermediate_01890 | Enterovirus A is reported to upregulate a gene that participates in G alpha (i) signalling events. In a specific study involving rhabdomyosarcoma cells, this gene exhibited a log2 fold change of 1.063 and an adjusted p-value of 0.04486. Which protein is encoded by this gene? | Somatostatin receptor type 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01890","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is reported to upregulate a gene that participates in G alpha (i) signalling events. In a specific study invol... | |
medium_hidden_intermediate_01894 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and associated with hypertensive disorder through genomic alterations. Experimental data for this gene in lung cells (study GSE155241) shows a log2 fold change of 3.322 and an adjusted p-value of 0.03112. Which disease is linked to this gene... | hyperlipidemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01894","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and associated with hypertensive disorder thr... | |
medium_hidden_intermediate_01896 | In a study of Measles morbillivirus infection, two genes are identified as being upregulated by the virus and interacting with STAU1. One of these genes exhibits a log2 fold change of approximately 1.296 and an adjusted p-value of 0.01556. Which protein is encoded by this specific gene? | Ankyrin repeat and KH domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01896","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, two genes are identified as being upregulated by the virus and interacting wi... | |
medium_hidden_intermediate_01897 | Two genes are upregulated by Vaccinia virus and interact with RHOB. One of these genes shows a log2 fold change of 1.462 and an adjusted p-value of 7.001e-07 in cervical adenocarcinoma cell lines. Which disease is associated with this specific gene? | B-cell chronic lymphocytic leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01897","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and interact with RHOB. One of these genes shows a log2 fold change of 1.462 and... | |
medium_hidden_intermediate_01898 | In a study of Measles morbillivirus infection, two genes are known to be upregulated by the virus and to interact with SOX2. One of these genes exhibits a log2 fold change of approximately 1.61 and an adjusted p-value of 0.0047. Which protein is encoded by this specific gene? | Pogo transposable element with ZNF domain | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01898","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, two genes are known to be upregulated by the virus and to interact with SOX2.... | |
medium_hidden_intermediate_01900 | Zika virus downregulates a specific gene, which in turn interacts with RNGTT. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -1.246 and an adjusted p-value of 0.00257. Which protein is encoded by this gene? | Serine/threonine-protein phosphatase 4 regulatory subunit 3B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01900","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with RNGTT. Experimental data for this gene in glioma stem... | |
medium_hidden_intermediate_01901 | Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to the process 'Synthesis of PIPs at the early endosome membrane' via a 'participates in' relationship. One of these genes has an associated expression profile showing a log2 fold change of approximately -1.233 an... | naive B cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01901","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to the process 'S... | |
medium_hidden_intermediate_01902 | Hepacivirus C is reported to upregulate a gene that is associated with obesity disorder. In a specific study, this gene exhibited a log2 fold change of 1.468 and an adjusted p-value of 0.01367. Which protein is encoded by this gene? | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01902","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to upregulate a gene that is associated with obesity disorder. In a specific study, this gene exhi... | |
medium_hidden_intermediate_01903 | In a study of Primate bocaparvovirus 1 infection, a specific gene is upregulated and its product is enriched in intermediate monocytes. Evidence for this gene reports a log2 fold change of 1.656 and an adjusted p-value of 0.03055. Which protein is encoded by this gene? | Cytosol aminopeptidase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01903","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Primate bocaparvovirus 1 infection, a specific gene is upregulated and its product is enriched in intermediate... | |
medium_hidden_intermediate_01904 | Pegivirus C downregulates a specific gene that enables GTP binding. In a study of peripheral blood mononuclear cells (GSE131504), this gene exhibited a log2 fold change of -3.971 and an adjusted p-value of 0.0315. Which biological process is this gene involved in? | GTP metabolic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01904","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a specific gene that enables GTP binding. In a study of peripheral blood mononuclear cells (GSE131... | |
medium_hidden_intermediate_01906 | In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and is associated with lymphoma. Transcriptomic data for this gene shows a log2 fold change of approximately 1.39 and an adjusted p-value of 0.014. Which protein is encoded by this gene? | Ecotropic viral integration site 5 protein homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01906","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and is associated with lymphoma. ... | |
medium_hidden_intermediate_01907 | Zika virus infection leads to the downregulation of genes involved in microtubule cytoskeleton organization. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -2.603 and an adjusted p-value of 0.009537. Which protein is encoded by this specific gene? | GAS2-like protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01907","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection leads to the downregulation of genes involved in microtubule cytoskeleton organization. In a study of g... | |
medium_hidden_intermediate_01908 | Vaccinia virus upregulates a gene that participates in zinc influx into cells via the SLC39 gene family. In a study of cervical adenocarcinoma cell lines (GSE11238), one such gene showed a log2 fold change of 1.042 and an adjusted p-value of 0.007844. Which protein is encoded by this gene? | Zinc transporter ZIP3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01908","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a gene that participates in zinc influx into cells via the SLC39 gene family. In a study of cervi... | |
medium_hidden_intermediate_01909 | Human alphaherpesvirus 3 is reported to downregulate a specific gene, which is in turn enriched in naive B cells. Experimental data for this gene in a melanoma cell line (study GSE136586) shows a log2 fold change of -1.204 and an adjusted p-value of 3.472e-08. Which protein is encoded by this gene? | CD180 antigen | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01909","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 is reported to downregulate a specific gene, which is in turn enriched in naive B cells. Experiment... | |
medium_hidden_intermediate_01910 | Zika virus downregulates a specific gene, which in turn interacts with HSPA8. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.292 and an adjusted p-value of 0.03229. Which protein is encoded by this gene? | Protein N-lysine methyltransferase METTL21A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01910","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with HSPA8. Experimental data for this gene in glioma stem... | |
medium_hidden_intermediate_01912 | Human betaherpesvirus 5 is reported to downregulate a gene that is involved in the positive regulation of cell population proliferation. Experimental data from a study on foreskin fibroblast cell lines (GSE111036) indicates that one such gene exhibits a log2 fold change of -1.742 and an adjusted p-value of 0.03653. Whi... | Cell cycle progression protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01912","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that is involved in the positive regulation of cell population pr... | |
medium_hidden_intermediate_01913 | Pegivirus C is reported to downregulate a gene that is located in the mitochondrial inner membrane. Evidence for one such gene indicates a log2 fold change of -1.459 and an adjusted p-value of 0.002132. Which disease is associated with this specific gene? | polydactyly, postaxial, type A9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01913","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is located in the mitochondrial inner membrane. Evidence for one such ge... | |
medium_hidden_intermediate_01915 | In a study of glioma stem cells (GSE114907), Zika virus infection leads to the downregulation of a specific gene, which in turn interacts with the protein YWHAE. This gene exhibits a log2 fold change of approximately -1.004 and an adjusted p-value of 0.01235. Which protein is encoded by this gene? | Phosphatidylinositide 4-phosphatase SAC2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01915","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), Zika virus infection leads to the downregulation of a specific gene, which in t... | |
medium_hidden_intermediate_01916 | Zika virus downregulates a gene that is involved in the endoplasmic reticulum unfolded protein response. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -1.144 and an adjusted p-value of 0.03152. Which protein is encoded by this gene? | Derlin-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01916","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the endoplasmic reticulum unfolded protein response. In a study of gliom... | |
medium_hidden_intermediate_01918 | Human betaherpesvirus 5 upregulates a gene that is involved in the negative regulation of cell migration. Evidence for this gene in foreskin fibroblast cell lines reports a log2 fold change of 3.582 and an adjusted p-value of 0.0004512. Which disease is associated with this gene? | retinal degeneration | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01918","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that is involved in the negative regulation of cell migration. Evidence for this ... | |
medium_hidden_intermediate_01920 | In a study of natural killer cells (GSE125686), Hepacivirus C infection leads to the upregulation of specific histone variants, which subsequently participate in the process where activated PKN1 stimulates the transcription of androgen receptor-regulated genes KLK2 and KLK3. One such intermediate entity was reported wi... | Histone H3.1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01920","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of natural killer cells (GSE125686), Hepacivirus C infection leads to the upregulation of specific histone varian... | |
medium_hidden_intermediate_01921 | Pegivirus C is reported to downregulate a specific gene product that is located in the extracellular region. Transcriptomic data from study GSE131504 indicates that this entity exhibits a log2 fold change of approximately -2.94 and an adjusted p-value of 0.00012. Which cell type is this entity enriched in? | naive thymus-derived CD8-positive, alpha-beta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01921","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene product that is located in the extracellular region. Transcriptomic ... | |
medium_hidden_intermediate_01922 | Pegivirus C is reported to downregulate a gene that is involved in lysosome organization. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -2.178 and an adjusted p-value of 0.0245. Which disease is associated with this specific gene? | leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01922","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in lysosome organization. In a study of peripheral blood mon... | |
medium_hidden_intermediate_01923 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by the virus and participates in phospholipid metabolism. This gene exhibits a log2 fold change of approximately 1.23 and an adjusted p-value of approximately 2.42e-10. Which protein does this gene pro... | MTMR7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01923","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by th... | |
medium_hidden_intermediate_01924 | Human immunodeficiency virus 1 downregulates a gene that participates in the metabolism of vitamins and cofactors. Evidence for this gene in macrophages (study GSE108897) reports a log2 fold change of approximately -1.03 and an adjusted p-value of 0.0087. Which cellular component is this gene located in? | cytosol | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01924","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in the metabolism of vitamins and cofactors. Evidence ... | |
medium_hidden_intermediate_01925 | Two genes are upregulated by Human immunodeficiency virus 1 and participate in CS-GAG biosynthesis. One of these genes exhibits a log2 fold change of 5.107 and an adjusted p-value of 0.001897 in macrophages. Which disease is associated with genomic alterations in this specific gene? | vitreoretinal degeneration | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01925","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and participate in CS-GAG biosynthesis. One of these genes exhib... | |
medium_hidden_intermediate_01926 | In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated by the virus and is involved in the killing of cells of another organism. This gene exhibits a log2 fold change of 8.719 and an adjusted p-value of 0.01104. Which protein is encoded by this gene? | C-C motif chemokine 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01926","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated by the virus and is... | |
medium_hidden_intermediate_01928 | A gene is downregulated by Human immunodeficiency virus 1 and participates in Viral Infection Pathways. Experimental data for this gene in macrophages (study GSE108897) reports a log2 fold change of -1.551 and an adjusted p-value of 0.007712. Which biological process is this gene involved in? | spermatogenesis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01928","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Human immunodeficiency virus 1 and participates in Viral Infection Pathways. Experimental data fo... | |
medium_hidden_intermediate_01930 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Dengue Virus Genome Translation and Replication. Evidence for this gene reports a log2 fold change of 1.370 and an adjusted p-value of 0.01414. Which protein is encoded by this gene? | Prolyl 4-hydroxylase subunit alpha-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01930","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Dengue Virus Genome Trans... | |
medium_hidden_intermediate_01933 | In a study of cardiomyocyte cell lines (GSE151879), a gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in UCH proteinases. This specific gene exhibits a log2 fold change of approximately 1.274 and an adjusted p-value of approximately 0.008. Which protein is encoded by this g... | Methyl-CpG-binding domain protein 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01933","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cardiomyocyte cell lines (GSE151879), a gene is upregulated by Severe acute respiratory syndrome-related coron... | |
medium_hidden_intermediate_01935 | A gene is downregulated by Human gammaherpesvirus 8 and participates in G alpha (q) signalling events. Experimental data for this gene in vascular endothelial cells shows a log2 fold change of -1.007 and an adjusted p-value of 0.01784. Which protein is encoded by this gene? | Lymphotactin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01935","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Human gammaherpesvirus 8 and participates in G alpha (q) signalling events. Experimental data for... | |
medium_hidden_intermediate_01936 | In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to upregulate a specific gene, which in turn interacts with VIM. This gene exhibited a log2 fold change of 3.828 and an adjusted p-value of 0.004368. Which protein is encoded by this gene? | Uridine phosphorylase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01936","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to upre... | |
medium_hidden_intermediate_01937 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which is involved in the cell surface receptor signaling pathway. This gene exhibits a log2 fold change of approximately -1.999 and an adjusted p-value of 0.02887. Which protein is encod... | Endothelin-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01937","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_01939 | Pegivirus C is reported to downregulate a specific gene, which in turn interacts with CUL4B. Experimental data for this intermediate gene in peripheral blood mononuclear cells (from study GSE131504) shows a log2 fold change of approximately -1.224 and an adjusted p-value of 0.002092. Which protein is encoded by this ge... | DNA (cytosine-5)-methyltransferase 3A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01939","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn interacts with CUL4B. Experimental data for this inte... | |
medium_hidden_intermediate_01941 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection leads to the downregulation of a gene that enables sequence-specific double-stranded DNA binding. One such gene exhibits a log2 fold change of -1.006 and an adjusted p-value of 0.03057. Which biological process is this specific gene i... | transcription by RNA polymerase II | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01941","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection leads to the downregulation of a gene ... | |
medium_hidden_intermediate_01942 | Measles morbillivirus upregulates a gene that is located in the early endosome. Experimental data for this gene reports a log2 fold change of 1.022 and an adjusted p-value of 0.001177. Which protein is encoded by this gene? | Sorting nexin-16 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01942","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is located in the early endosome. Experimental data for this gene reports a lo... | |
medium_hidden_intermediate_01946 | Pegivirus C is reported to downregulate a gene that participates in mitochondrial translation. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.282 and an adjusted p-value of 0.0006781. Which protein is encoded by this specific gene? | NADH-ubiquinone oxidoreductase chain 4L | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01946","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that participates in mitochondrial translation. In a study of peripheral bloo... | |
medium_hidden_intermediate_01947 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with hepatocellular carcinoma through genomic alterations. One of these genes exhibits a log2 fold change of approximately -4.09 and an adjusted p-value of approximately 0.0305 in bronchial epithelial cells. Which di... | non-small cell lung carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01947","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with hepatocellular ... | |
medium_hidden_intermediate_01948 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and its product interacts with RAC1. This gene exhibits a log2 fold change of approximately 1.273 and an adjusted p-value of 0.008516. Which protein is encoded by this gene? | Syntaxin-binding protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01948","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and its produc... | |
medium_hidden_intermediate_01949 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables protein kinase binding. Experimental data for this gene in choroid plexus epithelium shows a log2 fold change of approximately -1.018 and an adjusted p-value of 0.00431. Which protein does this gene interact with? | CDC7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01949","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables protein kinase binding. Experim... | |
medium_hidden_intermediate_01950 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate certain genes involved in protein metabolism. One such gene exhibited a log2 fold change of approximately -3.15 and an adjusted p-value of 0.0232. Which protein is encoded by this specific gene? | Protein cornichon homolog 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01950","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate certain gene... | |
medium_hidden_intermediate_01952 | Pegivirus C is reported to downregulate a specific gene, which in turn participates in neutrophil degranulation. In a study of peripheral blood mononuclear cells (GSE131504), this gene exhibited a log2 fold change of -1.546 and an adjusted p-value of 0.03924. Which protein is encoded by this gene? | Fibroleukin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01952","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn participates in neutrophil degranulation. In a study ... | |
medium_hidden_intermediate_01953 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of a specific gene, which subsequently interacts with BAG2. This gene exhibits a log2 fold change of approximately 4.92 and an adjusted p-value of 0.0027. To which cellular component is this upregulated gene localized? | protein phosphatase type 2A complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01953","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of a specific gene, whic... | |
medium_hidden_intermediate_01955 | Human alphaherpesvirus 1 upregulates a gene that participates in Metabolism. Evidence for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately 1.135 and an adjusted p-value of 0.002916. Which biological process is this gene involved in? | cognition | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01955","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that participates in Metabolism. Evidence for this gene in a monocytic leukemia ... |
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