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medium_hidden_intermediate_01956 | Cardiovirus A is reported to downregulate a gene that is associated with acute lymphoblastic leukemia. In a study of cervical adenocarcinoma cell lines (GSE122967), one such gene exhibits a log2 fold change of approximately -1.08 and an adjusted p-value of 0.017. Which protein is encoded by this specific gene? | Protein lin-9 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01956","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A is reported to downregulate a gene that is associated with acute lymphoblastic leukemia. In a study of cervica... | |
medium_hidden_intermediate_01957 | Two genes are structurally linked to Zika virus via downregulation and to FYN via binding. One of these genes exhibits a log2 fold change of -1.631 and an adjusted p-value of 0.01919 in glioma stem cells. Which disease is associated with this specific gene as a biomarker? | endometrial carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01957","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Zika virus via downregulation and to FYN via binding. One of these genes exhibits a log... | |
medium_hidden_intermediate_01958 | In a study of Influenza A virus infection, a specific gene is upregulated by the virus and participates in Interferon gamma signaling. Evidence for this gene reports a log2 fold change of approximately 1.13 and an adjusted p-value of 0.023. Which protein is encoded by this gene? | Platelet-activating factor receptor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01958","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is upregulated by the virus and participates in Interferon gamma ... | |
medium_hidden_intermediate_01961 | A gene is downregulated by Human betaherpesvirus 5 and participates in Leishmania infection. Experimental data for this gene in foreskin fibroblast cell lines (study GSE111036) reports a log2 fold change of -1.964 and an adjusted p-value of 0.04109. Which protein is encoded by this gene? | cAMP-dependent protein kinase catalytic subunit PRKX | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01961","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Human betaherpesvirus 5 and participates in Leishmania infection. Experimental data for this gene... | |
medium_hidden_intermediate_01966 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and its product is located in the centriole. Evidence for this gene reports a log2 fold change of approximately 1.164 and an adjusted p-value of 0.01042. Which protein is encoded by this gene? | Coiled-coil domain-containing protein 146 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01966","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and its produc... | |
medium_hidden_intermediate_01969 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Carboxyterminal post-translational modifications of tubulin. One of these genes exhibits a log2 fold change of approximately 1.008 and an adjusted p-value of 0.02914 in a specific study. Which biological process is thi... | protein polyglutamylation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01969","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Carboxyterminal post-t... | |
medium_hidden_intermediate_01971 | Human betaherpesvirus 5 is reported to upregulate a gene that participates in post-translational protein modification. In a study using foreskin fibroblast cell lines, one such gene showed a log2 fold change of 2.556 and an adjusted p-value of 0.001566. Which protein is encoded by this specific gene? | CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01971","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to upregulate a gene that participates in post-translational protein modification. In a ... | |
medium_hidden_intermediate_01975 | In studies of Severe acute respiratory syndrome-related coronavirus infection, certain host genes are upregulated and subsequently interact with BACH1. One such gene exhibits a log2 fold change of approximately 2.21 and an adjusted p-value of 0.04688. Which protein is encoded by this specific gene? | F-box only protein 22 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01975","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In studies of Severe acute respiratory syndrome-related coronavirus infection, certain host genes are upregulated and subseq... | |
medium_hidden_intermediate_01976 | Human immunodeficiency virus 1 upregulates a gene that participates in Programmed Cell Death. Evidence for this gene reports a log2 fold change of 1.261 and an adjusted p-value of 0.009405. Which protein is encoded by this gene? | TIR domain-containing adapter molecule 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01976","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in Programmed Cell Death. Evidence for this gene reports... | |
medium_hidden_intermediate_01978 | A gene is upregulated by Human gammaherpesvirus 8 and participates in the Immune System. Experimental data for this gene in umbilical vein endothelial cells (study GSE119608) shows a log2 fold change of approximately 1.185 and an adjusted p-value of approximately 0.0081. Which gene interacts with this identified gene? | ULBP1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01978","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human gammaherpesvirus 8 and participates in the Immune System. Experimental data for this gene in ... | |
medium_hidden_intermediate_01979 | Severe acute respiratory syndrome-related coronavirus is reported to downregulate a gene that enables protein serine/threonine kinase activity. Evidence for one such gene shows a log2 fold change of -1.004 and an adjusted p-value of 0.01584. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01979","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus is reported to downregulate a gene that enables protein serine/threoni... | |
medium_hidden_intermediate_01980 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and both bind to RPS14. One of these genes exhibits a log2 fold change of 1.614 and an adjusted p-value of 0.003875 in a specific study. Which protein is encoded by this gene? | Serine/threonine-protein kinase RIO2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01980","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and both bind to RPS14. One of these gene... | |
medium_hidden_intermediate_01981 | In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and involved in protein K48-linked deubiquitination. This specific gene exhibits a log2 fold change of -2.674 and an adjusted p-value of 0.003944. Which cellular component is this gene located in? | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01981","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and invo... | |
medium_hidden_intermediate_01983 | Human betaherpesvirus 5 downregulates a gene that is located in the Golgi membrane. Evidence for this gene reports a log2 fold change of -1.458 and an adjusted p-value of 0.002412. Which disease is associated with this gene? | carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01983","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 downregulates a gene that is located in the Golgi membrane. Evidence for this gene reports a log2 fo... | |
medium_hidden_intermediate_01984 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the negative regulation of apoptotic process. One of these genes exhibits a log2 fold change of approximately 2.53 and an adjusted p-value of 0.0134 in lung tissue data. Which cell type is enriched for this specific g... | non-classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01984","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the negative regulati... | |
medium_hidden_intermediate_01985 | In a study of umbilical vein endothelial cells (GSE119608), a gene is downregulated by Human gammaherpesvirus 8 and enables identical protein binding. This specific gene exhibits a log2 fold change of approximately -3.08 and an adjusted p-value of 0.0097. Which cellular component is this gene located in? | NADPH oxidase complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01985","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of umbilical vein endothelial cells (GSE119608), a gene is downregulated by Human gammaherpesvirus 8 and enables ... | |
medium_hidden_intermediate_01986 | In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to downregulate a gene involved in spermatid development. This specific gene exhibited a log2 fold change of -1.301 and an adjusted p-value of 0.005654. Which protein is encoded by this gene? | Nucleoside diphosphate kinase 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01986","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to down... | |
medium_hidden_intermediate_01987 | DYNC1LI1 interacts with a protein that possesses protein binding activity. One such interacting partner is known to inhibit the anaphase-promoting complex/cyclosome (APC/C) by binding to its mitotic activator Cdc20. Which protein is encoded by the gene corresponding to this interacting partner? | Mitotic spindle assembly checkpoint protein MAD2A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01987","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"DYNC1LI1 interacts with a protein that possesses protein binding activity. One such interacting partner is known to inhibit ... | |
medium_hidden_intermediate_01988 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to obesity disorder via an 'associated with' relationship. One of these genes has a reported log2 fold change of -1.425 and an adjusted p-value of 0.01949 in lung tissue data. Which protein ... | Interferon alpha-inducible protein 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01988","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_01989 | In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and is involved in protein localization to the perinuclear region of the cytoplasm. Evidence for this gene reports a log2 fold change of 1.254 and an adjusted p-value of 0.04253. Which protein is encoded by this gene? | FHF complex subunit HOOK-interacting protein 1A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01989","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and is involved in protein locali... | |
medium_hidden_intermediate_01990 | Hepacivirus C upregulates a specific gene, which is in turn enriched in conventional dendritic cells. Experimental data for this gene in hepatocytes (from study GSE132606) reports a log2 fold change of approximately 1.01 and an adjusted p-value of 0.0028. Which protein is encoded by this gene? | Zinc-regulated GTPase metalloprotein activator 1A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01990","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a specific gene, which is in turn enriched in conventional dendritic cells. Experimental data for ... | |
medium_hidden_intermediate_01991 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which is subsequently involved in lysosome organization. This gene exhibits a log2 fold change of approximately -1.193 and an adjusted p-value of 0.01729. Which protein interacts with th... | CTIF | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01991","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_01992 | Enterovirus A downregulates a specific gene that participates in cell junction organization. Transcriptomic data from rhabdomyosarcoma cells (study GSE103308) indicates this gene has a log2 fold change of approximately -1.9 and an adjusted p-value of approximately 0.012. In which cellular component is this gene product... | focal adhesion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01992","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A downregulates a specific gene that participates in cell junction organization. Transcriptomic data from rhabdo... | |
medium_hidden_intermediate_01998 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in Class A/1 (Rhodopsin-like receptors). One such gene exhibits a log2 fold change of approximately 3.98 and an adjusted p-value of approximately 0.0062. Which protein is encoded by this specific gene? | B1 bradykinin receptor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01998","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in Class A/1 (Rho... | |
medium_hidden_intermediate_01999 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes that subsequently interact with the protein YWHAB. One such gene exhibited a log2 fold change of approximately 2.15 and an adjusted p-value of approximately 1.5e-06. Which protein is encoded by th... | Glucocorticoid-induced transcript 1 protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01999","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes ... | |
medium_hidden_intermediate_02001 | In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and enables galactosyltransferase activity. This specific gene exhibits a log2 fold change of 1.252 and an adjusted p-value of 5.661e-05. Which protein is encoded by this gene? | Beta-1,4-galactosyltransferase 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02001","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and enables galactosyltransfe... | |
medium_hidden_intermediate_02002 | Pegivirus C downregulates a gene that enables GTPase activator activity. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.563 and an adjusted p-value of 0.0004147. Which biological process is this specific gene involved in? | actin filament-based process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02002","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that enables GTPase activator activity. In a study of peripheral blood mononuclear cells (G... | |
medium_hidden_intermediate_02003 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate genes involved in vesicle targeting from the trans-Golgi to the endosome. One such gene exhibited a log2 fold change of approximately 1.62 and an adjusted p-value of approximately 0.000138. Which protein is encoded ... | WD repeat domain phosphoinositide-interacting protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02003","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate genes involved in v... | |
medium_hidden_intermediate_02005 | Human immunodeficiency virus 1 upregulates a gene that interacts with RAD51. Evidence for one such gene in macrophages (study GSE108897) reports a log2 fold change of approximately 1.79 and an adjusted p-value of approximately 0.00063. Which cellular component is this gene located in? | Shu complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02005","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that interacts with RAD51. Evidence for one such gene in macrophages (stud... | |
medium_hidden_intermediate_02006 | Cardiovirus A downregulates a specific gene that participates in the RHOQ GTPase cycle. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of -1.029 and an adjusted p-value of 0.01325. Which cellular component is this gene located in? | Golgi apparatus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02006","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A downregulates a specific gene that participates in the RHOQ GTPase cycle. Experimental data for this gene in a... | |
medium_hidden_intermediate_02007 | BMP4 is involved in a biological process that is part of respiratory system development. One such process is defined as the progression of a trachea over time, from its formation to the mature structure, where the trachea is the portion of the airway that attaches to the bronchi. Which biological process is this entity... | animal organ development | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02007","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"BMP4 is involved in a biological process that is part of respiratory system development. One such process is defined as the ... | |
medium_hidden_intermediate_02009 | Pegivirus C is reported to downregulate a specific gene, which in turn participates in the regulation of the expression and function of Type I Classical Cadherins. Experimental data for this gene in peripheral blood mononuclear cells (from study GSE131504) indicates a log2 fold change of approximately -2.36 and an adju... | M-phase phosphoprotein 8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02009","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn participates in the regulation of the expression and ... | |
medium_hidden_intermediate_02010 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by the virus and is involved in heterochromatin formation. This gene exhibits a log2 fold change of approximately 1.27 and an adjusted p-value of approximately 1.035e-13. Which protein is encoded by th... | Histone H1.0 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02010","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by th... | |
medium_hidden_intermediate_02011 | Hepacivirus C is reported to downregulate a specific gene, which in turn participates in Transcriptional Regulation by TP53. Experimental data for this gene shows a log2 fold change of -1.215 and an adjusted p-value of 0.000851. Which protein is encoded by this gene? | Cytochrome c oxidase subunit 5B, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02011","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a specific gene, which in turn participates in Transcriptional Regulation by TP53.... | |
medium_hidden_intermediate_02017 | In the context of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and participates in Chondroitin sulfate/dermatan sulfate metabolism. Experimental data for this gene in lung tissue reports a log2 fold change of approximately -2.33 and an adjusted p-value of 0.0173. Whi... | Chondroitin sulfate synthase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02017","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In the context of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and part... | |
medium_hidden_intermediate_02020 | Two genes are linked to Human immunodeficiency virus 1 via an upregulation relationship and to mammary neoplasms, animal via a biomarker relationship. One of these genes is associated with a log2 fold change of 1.328 and an adjusted p-value of 0.006179. Which cell type is enriched for this specific gene? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02020","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Human immunodeficiency virus 1 via an upregulation relationship and to mammary neoplasms, animal via... | |
medium_hidden_intermediate_02021 | Measles morbillivirus upregulates a gene that participates in Mitotic Metaphase and Anaphase. In a study of pleural mesothelioma cells (GSE117668), one such gene showed a log2 fold change of approximately 3.42 and an adjusted p-value of 0.0004836. Which protein is encoded by this gene? | F-box only protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02021","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that participates in Mitotic Metaphase and Anaphase. In a study of pleural mesothel... | |
medium_hidden_intermediate_02024 | Human immunodeficiency virus 1 downregulates a gene that participates in RNA metabolism. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately -1.13 and an adjusted p-value of 0.0017. Which protein is encoded by this gene? | tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ALKBH8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02024","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in RNA metabolism. In a study of macrophages (GSE10889... | |
medium_hidden_intermediate_02025 | Human immunodeficiency virus 1 downregulates a specific gene, which in turn interacts with UBC. Experimental data for this gene in macrophages (from study GSE108897) reports a log2 fold change of approximately -1.64 and an adjusted p-value of 5.43e-06. Which disease is associated with this gene as a biomarker? | benign neoplasm of large intestine | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02025","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a specific gene, which in turn interacts with UBC. Experimental data for this g... | |
medium_hidden_intermediate_02026 | Two genes are identified as markers of microglial cells and are both involved in the positive regulation of the JNK cascade. One of these genes is described by evidence stating that 'Expression of the GADD45-like genes induces p38/JNK activation and apoptosis.' Which disease is associated with this specific gene as a b... | lung adenocarcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02026","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are identified as markers of microglial cells and are both involved in the positive regulation of the JNK cascade.... | |
medium_hidden_intermediate_02028 | A gene is upregulated by Primate bocaparvovirus 1 and is enriched in neutrophils. Evidence for this gene reports a log2 fold change of 1.050 and an adjusted p-value of 0.00074. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02028","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and is enriched in neutrophils. Evidence for this gene reports a log2 fold... | |
medium_hidden_intermediate_02029 | Zika virus downregulates a specific gene, which in turn interacts with the protein TCEB1. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -2.275 and an adjusted p-value of 0.004433. Which protein is encoded by this gene? | Nuclear receptor-binding protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02029","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with the protein TCEB1. Experimental data for this gene in... | |
medium_hidden_intermediate_02031 | A specific gene serves as a marker for CD4+ T cells and is associated with lymphoma. Research investigating this gene's potential as a marker for tumor cells in cutaneous lymphoma involved immunohistochemical staining of lesional skin from patch, plaque, and tumor stages. Which biological process is this gene involved ... | natural killer cell differentiation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02031","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A specific gene serves as a marker for CD4+ T cells and is associated with lymphoma. Research investigating this gene's pote... | |
medium_hidden_intermediate_02032 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which in turn interacts with UBE2I. This gene exhibits a log2 fold change of -1.035 and an adjusted p-value of 0.008652. Which protein is encoded by this downregulated gene? | Cyclic AMP-dependent transcription factor ATF-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02032","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_02033 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Triglyceride catabolism. One of these genes was reported in a study (GSE153218) using SAEC cells, showing a log2 fold change of 1.218 and an adjusted p-value of 0.04811. Which gene interacts with the gene identified by... | PNPLA2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02033","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Triglyceride catabolis... | |
medium_hidden_intermediate_02034 | Two genes are structurally linked to Human immunodeficiency virus 1 via an 'upregulates' relationship and to the process of Transcriptional regulation of white adipocyte differentiation via a 'participates in' relationship. One of these genes is reported in a study (GSE108897) involving macrophages, with a log2 fold ch... | esophagitis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02034","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via an 'upregulates' relationship and to the process of ... | |
medium_hidden_intermediate_02039 | Measles morbillivirus upregulates a gene that is involved in the positive regulation of cell migration involved in sprouting angiogenesis. Evidence for one such gene reports a log2 fold change of 1.145 and an adjusted p-value of 0.01104. Which protein is encoded by that gene? | Junctional cadherin 5-associated protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02039","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is involved in the positive regulation of cell migration involved in sprouting... | |
medium_hidden_intermediate_02040 | Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to Amyloid fiber formation via a 'participates in' relationship. One of these genes exhibits a log2 fold change of approximately -1.85 and an adjusted p-value of approximately 0.000815 in a specific study. Which c... | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02040","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to Amyloid fiber ... | |
medium_hidden_intermediate_02041 | A gene is downregulated by Primate bocaparvovirus 1 and participates in vesicle-mediated transport. Experimental evidence for this gene shows a log2 fold change of -2.290 and an adjusted p-value of 0.0003543. In which cell type is this gene enriched? | mucosal-associated invariant T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02041","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and participates in vesicle-mediated transport. Experimental evidence fo... | |
medium_hidden_intermediate_02042 | A gene expressed in epithelial cells (specifically SLC16A7+ cells) enables ubiquitin-like ligase-substrate adaptor activity. Evidence indicates that this gene product forms a complex with Cul5 to act as the E3 ligase targeting BIK for ubiquitination and degradation. Which protein is encoded by this gene? | Ankyrin repeat and SOCS box protein 11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02042","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene expressed in epithelial cells (specifically SLC16A7+ cells) enables ubiquitin-like ligase-substrate adaptor activity.... | |
medium_hidden_intermediate_02045 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, which in turn interacts with RNF5. This gene exhibited a log2 fold change of 2.850 and an adjusted p-value of 1.937e-11. Which protein is encoded by this gene? | BRI3-binding protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02045","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_02047 | Hepacivirus C is reported to downregulate a gene whose product is located in the cytosol. Experimental data for one such gene shows a log2 fold change of approximately -1.045 and an adjusted p-value of 0.04664. Which protein is encoded by this specific gene? | PR domain-containing protein 11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02047","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene whose product is located in the cytosol. Experimental data for one such gen... | |
medium_hidden_intermediate_02048 | A gene is upregulated by Vaccinia virus and serves as a biomarker for breast carcinoma. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of 2.172 and an adjusted p-value of 6.309e-05. Which protein is encoded by this gene? | Adenylate kinase isoenzyme 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02048","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Vaccinia virus and serves as a biomarker for breast carcinoma. Experimental data for this gene in a... | |
medium_hidden_intermediate_02052 | A protein interacts with GRB2 and is located in the plasma membrane. Evidence indicates that this protein, like c-cbl, is phosphorylated and recruited to the EGFR upon EGF stimulation, and it can bind to the Grb2 adaptor protein. Which protein is encoded by the gene corresponding to this entity? | E3 ubiquitin-protein ligase CBL-B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02052","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A protein interacts with GRB2 and is located in the plasma membrane. Evidence indicates that this protein, like c-cbl, is ph... | |
medium_hidden_intermediate_02053 | In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and involved in the B cell receptor signaling pathway. This specific gene exhibits a log2 fold change of approximately -1.348 and an adjusted p-value of 0.01849. Which protein is encoded by this gene? | Tyrosine-protein kinase Tec | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02053","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and invo... | |
medium_hidden_intermediate_02054 | Measles morbillivirus downregulates multiple genes that are involved in signal transduction. One such gene exhibits a log2 fold change of approximately -1.003 and an adjusted p-value of 3.136e-06 in pleural mesothelioma cells. Which protein interacts with this specific gene product? | RAF1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02054","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus downregulates multiple genes that are involved in signal transduction. One such gene exhibits a log2 f... | |
medium_hidden_intermediate_02056 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the inflammatory response. Experimental data for this gene shows a log2 fold change of approximately 1.55 and an adjusted p-value of approximately 0.037. In which cellular component is this gene product located? | cytosol | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02056","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the inflammatory response.... | |
medium_hidden_intermediate_02057 | Human immunodeficiency virus 1 upregulates a gene that enables sequence-specific DNA binding. Evidence for this gene reports a log2 fold change of 2.511 and an adjusted p-value of 0.0009569. Which cell type is this gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02057","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that enables sequence-specific DNA binding. Evidence for this gene reports... | |
medium_hidden_intermediate_02059 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a gene that subsequently binds to MCM2. One such gene exhibits a log2 fold change of 1.461 and an adjusted p-value of 0.0005737. Which protein is encoded by this specific gene? | Protein DBF4 homolog A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02059","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a gene that subsequently binds to MC... | |
medium_hidden_intermediate_02061 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in MAPK6/MAPK4 signaling. Experimental evidence for this gene shows a log2 fold change of approximately -1.28 and an adjusted p-value of 0.0078. Which disease is associated with this gene as a biomarker? | desmoplastic small round cell tumor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02061","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in MAPK6/MAPK4 signaling. ... | |
medium_hidden_intermediate_02062 | Two genes are upregulated by Human immunodeficiency virus 1 and are involved in the negative regulation of the canonical Wnt signaling pathway. One of these genes exhibits a log2 fold change of 1.186 and an adjusted p-value of 0.001132 in a specific study. Which disease is associated with this specific gene? | carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02062","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and are involved in the negative regulation of the canonical Wnt... | |
medium_hidden_intermediate_02063 | In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to downregulate a gene involved in cartilage development. This specific gene exhibited a log2 fold change of -2.885 and an adjusted p-value of 1.89e-05. Which protein is encoded by this gene? | Transcription factor HES-5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02063","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to down... | |
medium_hidden_intermediate_02065 | In a study of cytotoxic T-lymphocytes (GSE106475), Rhinovirus A infection leads to the downregulation of certain genes that participate in infectious disease processes. One such gene exhibits a log2 fold change of approximately -2.86 and an adjusted p-value of 0.024. Which protein is encoded by this specific gene? | Histone H3.1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02065","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cytotoxic T-lymphocytes (GSE106475), Rhinovirus A infection leads to the downregulation of certain genes that ... | |
medium_hidden_intermediate_02067 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the upregulation of a specific gene, which in turn encodes a protein that binds to HCST. The expression data for this gene shows a log2 fold change of 1.136 and an adjusted p-value of 0.01485. Which protein is encoded by this... | UL16-binding protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02067","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the upregulation of a specifi... | |
medium_hidden_intermediate_02069 | Zika virus downregulates a specific gene that is involved in anatomical structure morphogenesis. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -1.744 and an adjusted p-value of 0.02348. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02069","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is involved in anatomical structure morphogenesis. In a study of glioma stem c... | |
medium_hidden_intermediate_02072 | Severe acute respiratory syndrome-related coronavirus is reported to downregulate a gene that is involved in the endothelin receptor signaling pathway. Evidence for one such gene indicates a log2 fold change of -2.321 and an adjusted p-value of 0.04538. Which protein is encoded by this gene? | Endothelin-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02072","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus is reported to downregulate a gene that is involved in the endothelin ... | |
medium_hidden_intermediate_02073 | Two genes are upregulated by Vaccinia virus and participate in Complex I biogenesis. One of these genes exhibits a log2 fold change of 1.531 and an adjusted p-value of 8.97e-08 in cervical adenocarcinoma cell lines. Which disease is associated with this specific gene? | mitochondrial complex I deficiency, nuclear type 39 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02073","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and participate in Complex I biogenesis. One of these genes exhibits a log2 fold... | |
medium_hidden_intermediate_02074 | Pegivirus C is reported to downregulate a specific gene, which is subsequently involved in the negative regulation of cytoplasmic translation. Experimental data for this gene in peripheral blood mononuclear cells (from study GSE131504) indicate a log2 fold change of approximately -1.08 and an adjusted p-value of 0.0097... | Cytoplasmic polyadenylation element-binding protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02074","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which is subsequently involved in the negative regulation of cytopl... | |
medium_hidden_intermediate_02075 | Two genes are upregulated by Human immunodeficiency virus 1 and are associated with breast carcinoma. One of these genes exhibits a log2 fold change of 4.148 and an adjusted p-value of 0.002708 in macrophages (study GSE108897). Which disease is linked to this specific gene as a therapeutic target? | hepatocellular carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02075","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and are associated with breast carcinoma. One of these genes exh... | |
medium_hidden_intermediate_02076 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Rab regulation of trafficking. Evidence for one such gene reports a log2 fold change of 1.227 and an adjusted p-value of 0.001001. Which cell type is that gene enriched in? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02076","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Rab regulation of trafficking.... | |
medium_hidden_intermediate_02077 | A gene is upregulated by Vaccinia virus and participates in Viral Infection Pathways. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of 2.368 and an adjusted p-value of 1.233e-09. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02077","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Vaccinia virus and participates in Viral Infection Pathways. Experimental data for this gene in a c... | |
medium_hidden_intermediate_02078 | A gene is upregulated by Measles morbillivirus and participates in infectious disease. Experimental data for this gene reports a log2 fold change of 1.680 and an adjusted p-value of 0.01627. Which disease is associated with this gene as a biomarker? | colorectal carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02078","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and participates in infectious disease. Experimental data for this gene repor... | |
medium_hidden_intermediate_02079 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene that enables transcription cis-regulatory region binding. This gene exhibited a log2 fold change of approximately -2.21 and an adjusted p-value of 0.0353. Which protein is encoded by this gene? | AT-rich interactive domain-containing protein 5B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02079","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene that enables... | |
medium_hidden_intermediate_02080 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection leads to the downregulation of certain genes that are subsequently found in extracellular exosomes. One such gene exhibits a log2 fold change of -1.197 and an adjusted p-value of 0.001581. What molecular function is enabled by this sp... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02080","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection leads to the downregulation of certain... | |
medium_hidden_intermediate_02081 | CDKN1A interacts with a protein that is located in the cytoplasm. Evidence indicates that a specific kinase specifically interacted with cyclin D3 (CCND3) and formed a ternary complex with the cell cycle inhibitor p21(Cip1) in mammalian cells. Which disease is associated with the entity described by this evidence? | squamous cell carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02081","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"CDKN1A interacts with a protein that is located in the cytoplasm. Evidence indicates that a specific kinase specifically int... | |
medium_hidden_intermediate_02083 | Two distinct proteins form a binding bridge between envoplakin (EVPL) and SPRR1B. One of these intermediate proteins is characterized by an N-terminal domain that interacts with the plasma membrane, a rod domain that mediates heterodimerization with envoplakin, and a C-terminus that interacts with intermediate filament... | Periplakin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02083","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct proteins form a binding bridge between envoplakin (EVPL) and SPRR1B. One of these intermediate proteins is char... | |
medium_hidden_intermediate_02084 | Zika virus upregulates a gene that participates in cellular responses to stress. Evidence for one such gene reports a log2 fold change of 2.605 and an adjusted p-value of 0.02977. Which disease is associated with that gene as a biomarker? | mycosis fungoides | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02084","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that participates in cellular responses to stress. Evidence for one such gene reports a log2 f... | |
medium_hidden_intermediate_02085 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are located in the cytoplasmic vesicle. One of these genes exhibits a log2 fold change of approximately -1.57 and an adjusted p-value of approximately 0.012 in a specific study. Which cell type is enriched for this specific gene? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02085","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are located in the cytoplasmic vesi... | |
medium_hidden_intermediate_02088 | Human alphaherpesvirus 1 upregulates a gene that interacts with SKP1. In a study of monocytic leukemia cell lines (GSE114966), one such gene exhibits a log2 fold change of approximately 3.04 and an adjusted p-value of approximately 0.015. Which protein is encoded by this gene? | F-box only protein 43 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02088","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that interacts with SKP1. In a study of monocytic leukemia cell lines (GSE114966... | |
medium_hidden_intermediate_02089 | HSPA1A interacts with a gene product that enables protein binding. Evidence regarding this entity states: 'It is demonstrated that the N-terminal regulates the activity of the complex and it is shown that complex formation takes place surprisingly via the C-terminal of MATβV2 that buries itself in a tunnel created at t... | MAT2B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02089","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"HSPA1A interacts with a gene product that enables protein binding. Evidence regarding this entity states: 'It is demonstrate... | |
medium_hidden_intermediate_02092 | In a study of non-small cell lung adenocarcinoma cell lines (GSE106279), a gene upregulated by Influenza A virus and enabling cysteine-type endopeptidase activity showed a log2 fold change of 1.839 and an adjusted p-value of 0.008354. Which disease is associated with genomic alterations in this specific gene? | lymphoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02092","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE106279), a gene upregulated by Influenza A virus and enablin... | |
medium_hidden_intermediate_02093 | Zika virus downregulates a specific gene that participates in rRNA processing. In glioma stem cells, this gene exhibits a log2 fold change of -2.536 and an adjusted p-value of 0.006108. Which biological process is this gene involved in? | mitochondrial tRNA 5'-end processing | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02093","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in rRNA processing. In glioma stem cells, this gene exhibits a lo... | |
medium_hidden_intermediate_02094 | Pegivirus C is reported to downregulate a gene that participates in retinoid metabolism and transport. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.163 and an adjusted p-value of 0.02855. Which protein is encoded by this specific gene? | Carotenoid-cleaving dioxygenase, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02094","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that participates in retinoid metabolism and transport. In a study of periphe... | |
medium_hidden_intermediate_02095 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate certain genes that participate in translation. One such gene exhibited a log2 fold change of 1.771 and an adjusted p-value of 1.366e-05. Which biological process is this specific gene involved in? | mitochondrial translational elongation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02095","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate certain genes that ... | |
medium_hidden_intermediate_02097 | Pegivirus C is reported to downregulate a gene that is located in the ribonucleoprotein complex. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.393 and an adjusted p-value of 0.01095. Which disease is associated with this specific gene? | combined oxidative phosphorylation deficiency 58 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02097","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is located in the ribonucleoprotein complex. In a study of peripheral bl... | |
medium_hidden_intermediate_02098 | In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upregulate a gene that participates in the Circadian clock. One such gene exhibited a log2 fold change of approximately 1.18 and an adjusted p-value of 0.0099. Which protein does this specific gene int... | DDIT3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02098","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upreg... | |
medium_hidden_intermediate_02099 | Two genes are upregulated by Human alphaherpesvirus 1 and are enriched in eosinophils. One of these genes exhibits a log2 fold change of 1.039 and an adjusted p-value of 0.008518 in a monocytic leukemia cell line study (GSE114966). Which biological process is the gene matching these statistics involved in? | positive regulation of ferroptosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02099","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human alphaherpesvirus 1 and are enriched in eosinophils. One of these genes exhibits a log2 fo... | |
medium_hidden_intermediate_02100 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in the metabolism of nucleotides. Experimental data for this gene in lung cells (study GSE148697) show a log2 fold change of -2.832 and an adjusted p-value of 0.0002383. Which disease is associated with genomic alterations... | malignant pancreatic neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02100","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in the metabolism of nucle... | |
medium_hidden_intermediate_02102 | Human alphaherpesvirus 1 upregulates a gene that enables protein phosphatase inhibitor activity. In a study of monocytic leukemia cell lines (GSE114966), one such gene showed a log2 fold change of 2.021 and an adjusted p-value of 0.002671. Which protein is encoded by this gene? | Pleiotrophin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02102","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that enables protein phosphatase inhibitor activity. In a study of monocytic leu... | |
medium_hidden_intermediate_02103 | The protein ANK3 is involved in a biological process that is a subtype of membrane organization. Evidence for one such process describes it as 'The aggregation, arrangement and bonding together of a set of components to form a membrane.' Which biological process is this specific entity a part of? | membrane biogenesis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02103","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"The protein ANK3 is involved in a biological process that is a subtype of membrane organization. Evidence for one such proce... | |
medium_hidden_intermediate_02106 | COL1A2 is involved in a biological process that is a subtype of animal organ morphogenesis. Evidence for one such process describes it as the generation and organization of the anatomical structures of the skin, which serves as the external membranous integument of an animal and typically consists of an outer epidermis... | skin of body | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02106","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"COL1A2 is involved in a biological process that is a subtype of animal organ morphogenesis. Evidence for one such process de... | |
medium_hidden_intermediate_02107 | Zika virus upregulates a gene that participates in the response of EIF2AK4 (GCN2) to amino acid deficiency. Evidence for this gene in glioblastoma multiforme cancer stem cells (study GSE102924) reports a log2 fold change of 1.212 and an adjusted p-value of 0.01901. Which disease is associated with this gene? | lung neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02107","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that participates in the response of EIF2AK4 (GCN2) to amino acid deficiency. Evidence for thi... | |
medium_hidden_intermediate_02108 | Zika virus downregulates a specific gene that is involved in the negative regulation of the apoptotic process. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.20 and an adjusted p-value of 0.0382. Which disease is associated with this gene as a bioma... | intrahepatic cholangiocarcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02108","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is involved in the negative regulation of the apoptotic process. Experimental ... | |
medium_hidden_intermediate_02110 | Two genes are identified as markers in fetal germ cells and both enable GTP binding. One of these genes, a glutamate dehydrogenase, is reported to be markedly inhibited by GTP (IC50 = 0.20 microM) in its nonactivated state. Which disease is associated with genomic alterations in this specific gene? | hyperinsulinism-hyperammonemia syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02110","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are identified as markers in fetal germ cells and both enable GTP binding. One of these genes, a glutamate dehydro... | |
medium_hidden_intermediate_02111 | Zika virus downregulates a specific gene that is associated with leukemia. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -1.274 and an adjusted p-value of 0.02871. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02111","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is associated with leukemia. In a study of glioma stem cells (GSE114907), this... | |
medium_hidden_intermediate_02112 | Hepacivirus C is reported to upregulate a gene that subsequently binds to UBE2M. Experimental data for one such intermediate gene shows a log2 fold change of approximately 1.246 and an adjusted p-value of 0.004057. Which protein is encoded by this specific gene? | Protein fem-1 homolog C | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02112","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to upregulate a gene that subsequently binds to UBE2M. Experimental data for one such intermediate... | |
medium_hidden_intermediate_02113 | A gene is downregulated by Primate bocaparvovirus 1 and is involved in the positive regulation of GTPase activity. Experimental evidence for this gene reports a log2 fold change of -1.974 and an adjusted p-value of 0.03962. Which protein is encoded by this gene? | TBC1 domain family member 2A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02113","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and is involved in the positive regulation of GTPase activity. Experimen... | |
medium_hidden_intermediate_02115 | Two distinct proteins are known to bind CDC42 and participate in the 'Signaling by Rho GTPases' pathway. Experimental evidence specifically verifies that CEP2 and a second protein bind Cdc42. Which molecular function is enabled by the protein identified in this experimental evidence? | small GTPase binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02115","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct proteins are known to bind CDC42 and participate in the 'Signaling by Rho GTPases' pathway. Experimental eviden... | |
medium_hidden_intermediate_02116 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to DLG4 via a 'binds' relationship. One of these genes is associated with experimental data showing a log2 fold change of approximately -2.98 and an adjusted p-value of approximately 0.047. ... | Voltage-dependent calcium channel gamma-4 subunit | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02116","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_02117 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes that enable cerebroside transfer activity. One such gene exhibited a log2 fold change of 1.403 and an adjusted p-value of 8.178e-06. Which protein is encoded by this specific gene? | Pleckstrin homology domain-containing family A member 8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02117","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes... |
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