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medium_hidden_intermediate_02118 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the downregulation of a specific gene that participates in the regulation of homotypic cell-cell adhesion. This gene exhibits a log2 fold change of -3.396 and an adjusted p-value of 0.006248. Which cellular component is this gene ... | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02118","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the downregulation of a specific g... | |
medium_hidden_intermediate_02121 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of a specific gene, which in turn is associated with Complex III assembly. One such gene exhibits a log2 fold change of approximately 1.393 and an adjusted p-value of 0.01384. Which protein is encoded by this upregulated... | Ubiquinol-cytochrome c reductase complex assembly factor 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02121","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of a specific gene, whic... | |
medium_hidden_intermediate_02122 | A gene is upregulated by Hepacivirus C and participates in Phospholipid metabolism. Evidence for this gene reports a log2 fold change of 1.233 and an adjusted p-value of 0.0001753. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02122","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Hepacivirus C and participates in Phospholipid metabolism. Evidence for this gene reports a log2 fo... | |
medium_hidden_intermediate_02125 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of a specific gene, which in turn interacts with GNAI3. This gene exhibits a log2 fold change of approximately -1.21 and an adjusted p-value of 0.040. What protein is encoded by this gene? | Atypical chemokine receptor 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02125","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of a specific gene, wh... | |
medium_hidden_intermediate_02127 | Human betaherpesvirus 5 upregulates a gene whose product is located in the extracellular space. In a study of foreskin fibroblast cell lines, one such gene showed a log2 fold change of approximately 1.32 and an adjusted p-value of 0.003781. Which protein is encoded by this specific gene? | Corticosteroid-binding globulin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02127","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene whose product is located in the extracellular space. In a study of foreskin fibro... | |
medium_hidden_intermediate_02128 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene that is downregulated by the virus and enables protein kinase activity was found to have a log2 fold change of approximately -1.074 and an adjusted p-value of 0.04332. Which gene interacts with this specific do... | AATK | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02128","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene that is downre... | |
medium_hidden_intermediate_02129 | Human immunodeficiency virus 1 downregulates a gene that is located in the mitochondrial inner membrane. Evidence for this gene reports a log2 fold change of -1.416 and an adjusted p-value of 0.001689. Which protein is encoded by this gene? | Mitochondrial glutathione transporter SLC25A39 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02129","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is located in the mitochondrial inner membrane. Evidence for this g... | |
medium_hidden_intermediate_02130 | A gene is downregulated by Human immunodeficiency virus 1 and participates in Chromatin organization. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of -1.368 and an adjusted p-value of 0.02745. Which disease is connected to this gene through genomic alterations? | male infertility | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02130","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Human immunodeficiency virus 1 and participates in Chromatin organization. Evidence for this gene... | |
medium_hidden_intermediate_02131 | Pegivirus C is associated with the downregulation of a gene that enables phosphatidylcholine transfer activity. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -1.325 and an adjusted p-value of 0.004028. Which protein is encoded by this specific ... | Phosphatidylinositol transfer protein beta isoform | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02131","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is associated with the downregulation of a gene that enables phosphatidylcholine transfer activity. In a study o... | |
medium_hidden_intermediate_02132 | Zika virus upregulates a gene that enables DNA-binding transcription activator activity, RNA polymerase II-specific. Evidence for this gene reports a log2 fold change of 1.137 and an adjusted p-value of 0.002946. Which protein is encoded by this gene? | Zinc finger X-chromosomal protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02132","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that enables DNA-binding transcription activator activity, RNA polymerase II-specific. Evidenc... | |
medium_hidden_intermediate_02134 | Pegivirus C is reported to downregulate multiple genes that enable DNA-binding transcription repressor activity, RNA polymerase II-specific. One such gene exhibits a log2 fold change of -2.789 and an adjusted p-value of 4.662e-05 in peripheral blood mononuclear cells (study GSE131504). Which disease is associated with ... | melanoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02134","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate multiple genes that enable DNA-binding transcription repressor activity, RNA polymer... | |
medium_hidden_intermediate_02136 | RELA interacts with a specific protein that enables protein binding. Structural evidence for this protein describes its complex with a RelA peptide containing the methylation site in the presence of S-adenosyl-L-methionine, revealing a V-like structure and suggesting a model for NF-κB binding. Which protein is encoded ... | N-lysine methyltransferase SETD6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02136","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"RELA interacts with a specific protein that enables protein binding. Structural evidence for this protein describes its comp... | |
medium_hidden_intermediate_02137 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the ceramide metabolic process. One of these genes exhibits a log2 fold change of approximately 1.19 and an adjusted p-value of approximately 3.22e-05 in a specific study. Which disease is associated with this gene as... | squamous cell carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02137","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the ceramide metaboli... | |
medium_hidden_intermediate_02139 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and to SOS1 via a 'binds' relationship. One of these genes is associated with a log2 fold change of 1.894 and an adjusted p-value of 1.108e-05 in a specific study context. Which disease is connec... | Klinefelter syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02139","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship... | |
medium_hidden_intermediate_02140 | Zika virus downregulates a gene that is located in the mitochondrial matrix. Experimental data from glioma stem cells (study GSE114907) indicates that this specific gene has a log2 fold change of -3.164 and an adjusted p-value of 0.01624. Which protein is encoded by this gene? | Nucleic acid dioxygenase ALKBH1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02140","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in the mitochondrial matrix. Experimental data from glioma stem cells (study... | |
medium_hidden_intermediate_02141 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Rab regulation of trafficking. Evidence for one such gene reports a log2 fold change of 1.281 and an adjusted p-value of 5.385e-06. Which protein is encoded by that gene? | DENN domain-containing protein 5B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02141","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Rab regulation of trafficking.... | |
medium_hidden_intermediate_02143 | In a study of macrophages (GSE108897), a gene is identified as a biomarker for breast carcinoma and is downregulated by Human immunodeficiency virus 1. This specific gene exhibits a log2 fold change of -1.832 and an adjusted p-value of 0.008704. Which protein is encoded by this gene? | Macrophage immunometabolism regulator | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02143","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified as a biomarker for breast carcinoma and is downregulated by Huma... | |
medium_hidden_intermediate_02144 | Rhinovirus A infection is associated with the upregulation of specific genes that participate in cellular responses to stress. One such gene exhibits a log2 fold change of approximately 1.636 and an adjusted p-value of 0.0004572 in cytotoxic T-lymphocytes. Which cell type is this gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02144","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection is associated with the upregulation of specific genes that participate in cellular responses to stres... | |
medium_hidden_intermediate_02148 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Sensory Perception. Experimental data for this gene reports a log2 fold change of 1.002 and an adjusted p-value of 0.04134. Which biological process is this gene involved in? | retinol metabolic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02148","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Sensory Perception. Exper... | |
medium_hidden_intermediate_02149 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and its product is located in the cytoplasmic stress granule. Evidence for this gene reports a log2 fold change of 1.073 and an adjusted p-value of 0.00602. Which protein is encoded by this gene? | Intracellular hyaluronan-binding protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02149","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and its produc... | |
medium_hidden_intermediate_02150 | Hepacivirus C is reported to upregulate a gene that participates in the pathway 'Signaling by Rho GTPases, Miro GTPases and RHOBTB3'. Evidence for this specific gene reports a log2 fold change of 1.035 and an adjusted p-value of 0.0219. Which protein is encoded by this gene? | Rho GDP-dissociation inhibitor 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02150","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to upregulate a gene that participates in the pathway 'Signaling by Rho GTPases, Miro GTPases and ... | |
medium_hidden_intermediate_02151 | A protein entity is connected to GNAI1 via a binding interaction and is associated with the molecular function of protein binding. Evidence regarding this entity states: 'Both regions interact exclusively with G alpha(i1), G alpha(i2), and G alpha(i3) in their GDP-bound forms.' Which cellular component is this entity l... | spindle | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02151","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A protein entity is connected to GNAI1 via a binding interaction and is associated with the molecular function of protein bi... | |
medium_hidden_intermediate_02152 | Pegivirus C is reported to downregulate a gene that enables protein serine/threonine kinase activity. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibits a log2 fold change of approximately -1.636 and an adjusted p-value of 0.04601. Which cellular component is this specific gene located... | ciliary tip | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02152","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that enables protein serine/threonine kinase activity. In a study of peripher... | |
medium_hidden_intermediate_02154 | In a study of Influenza A virus infection, a specific gene is upregulated by the virus and its product binds to GNAI3. Evidence for this gene reports a log2 fold change of 1.266 and an adjusted p-value of 0.0001103. Which protein is encoded by this gene? | Atypical chemokine receptor 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02154","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is upregulated by the virus and its product binds to GNAI3. Evide... | |
medium_hidden_intermediate_02158 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the resolution of D-loop structures through Holliday junction intermediates. Evidence for this gene reports a log2 fold change of 1.557 and an adjusted p-value of 0.02831. Which protein is encoded by this gene? | FIGNL1-interacting regulator of recombination and mitosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02158","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the resolution of D-loop ... | |
medium_hidden_intermediate_02159 | Two genes are downregulated by Human immunodeficiency virus 1 and interact with TP53. One of these genes exhibits a log2 fold change of -2.044 and an adjusted p-value of 0.0007951 in macrophages (study GSE108897). Which disease is associated with this specific gene? | carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02159","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Human immunodeficiency virus 1 and interact with TP53. One of these genes exhibits a log2 fol... | |
medium_hidden_intermediate_02160 | Two genes are structurally linked to Influenza A virus via a downregulation relationship and to Naive B cells via an enrichment relationship. One of these genes is reported in study GSE147507 with a log2 fold change of -1.166 and an adjusted p-value of 0.000121. Which disease is associated with this specific gene as a ... | lung cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02160","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Influenza A virus via a downregulation relationship and to Naive B cells via an enrichm... | |
medium_hidden_intermediate_02161 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in intracellular protein localization. Evidence for this gene reports a log2 fold change of approximately -2.007 and an adjusted p-value of 0.04371. Which protein is encoded by this gene? | Coiled-coil domain-containing protein 68 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02161","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in intracellular protein localiz... | |
medium_hidden_intermediate_02164 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and located in the endoplasmic reticulum lumen. Experimental data for this gene reports a log2 fold change of approximately 1.064 and an adjusted p-value of 0.002298. Which biological process is this gene involved in? | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02164","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and located in the endoplasmic reticulum lume... | |
medium_hidden_intermediate_02166 | Zika virus downregulates a specific gene that subsequently interacts with CEP63. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.104 and an adjusted p-value of 0.03278. Which biological process is this gene involved in? | regulation of cilium assembly | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02166","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that subsequently interacts with CEP63. Experimental data for this gene in glioma s... | |
medium_hidden_intermediate_02167 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Class A/1 (Rhodopsin-like receptors). Evidence for this gene reports a log2 fold change of -1.941 and an adjusted p-value of 0.02165. Which cellular component is this gene located in? | extracellular region | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02167","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Class A/1 (Rhodopsin-li... | |
medium_hidden_intermediate_02168 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE148697), two genes are downregulated by the virus and interact with UBC. One of these genes exhibits a log2 fold change of -1.073 and an adjusted p-value of 7.346e-05. Which biological process is associated with this specif... | translational elongation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02168","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE148697), two genes are down... | |
medium_hidden_intermediate_02171 | Zika virus downregulates a gene that participates in the TBC/RABGAPs protein family. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -2.298 and an adjusted p-value of 0.02392. Which biological process is this gene involved in? | regulation of cilium assembly | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02171","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in the TBC/RABGAPs protein family. In a study of glioma stem cells (GSE114... | |
medium_hidden_intermediate_02172 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in Cell-Cell communication. This specific gene exhibits a log2 fold change of 3.835 and an adjusted p-value of 0.004483. Which biological process is this gene involved in? | tight junction assembly | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02172","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in Cell-Cell comm... | |
medium_hidden_intermediate_02174 | In a study of Primate bocaparvovirus 1 infection, a specific gene is upregulated and participates in Rab regulation of trafficking. Evidence for this gene reports a log2 fold change of 1.001 and an adjusted p-value of 0.03936. Which protein is encoded by this gene? | TBC1 domain family member 16 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02174","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Primate bocaparvovirus 1 infection, a specific gene is upregulated and participates in Rab regulation of traff... | |
medium_hidden_intermediate_02176 | Zika virus downregulates a gene that is involved in the positive regulation of canonical NF-kappaB signal transduction. Experimental data from glioma stem cells (study GSE114907) indicates that this specific gene has a log2 fold change of approximately -2.09 and an adjusted p-value of 0.0343. Which protein is encoded b... | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02176","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the positive regulation of canonical NF-kappaB signal transduction. Expe... | |
medium_hidden_intermediate_02177 | A gene serves as a marker for Paneth cells and is also enriched in classical monocytes. Evidence for this gene includes a mean expression of 97.99 TPM, a z-score of 1.60, and a fold enrichment of 4.14. Which disease is associated with this gene? | gastric cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02177","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for Paneth cells and is also enriched in classical monocytes. Evidence for this gene includes a me... | |
medium_hidden_intermediate_02179 | Triamcinolone and Epoprostenol are both known to interact with a specific non-steroidal anti-inflammatory drug (NSAID). Research indicates that among several NSAIDs, this specific entity (ranked after indomethacin, SC-560, and celecoxib in potency) evoked significantly greater constriction of vasa recta capillaries at ... | osteoarthritis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02179","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Triamcinolone and Epoprostenol are both known to interact with a specific non-steroidal anti-inflammatory drug (NSAID). Rese... | |
medium_hidden_intermediate_02180 | In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and is involved in central nervous system development. This specific gene exhibits a log2 fold change of approximately 2.406 and an adjusted p-value of 1.4e-07. Which protein is encoded by this gene? | Aldehyde dehydrogenase family 3 member A2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02180","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and is involved in central ne... | |
medium_hidden_intermediate_02182 | Two genes are structurally linked to Human betaherpesvirus 5 via a 'downregulates' relationship and to Plasmacytoid dendritic cells (pDCs) via an 'enriched in' relationship. One of these genes has been reported in a study with a log2 fold change of approximately -1.139 and an adjusted p-value of 0.0005909. Which diseas... | Malignant tumor of urinary bladder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02182","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human betaherpesvirus 5 via a 'downregulates' relationship and to Plasmacytoid dendriti... | |
medium_hidden_intermediate_02186 | In a study of Influenza A virus infection, a specific gene is upregulated and is involved in the negative regulation of endothelial cell proliferation. Evidence for this gene reports a log2 fold change of approximately 1.14 and an adjusted p-value of 9.86e-06. Which disease is associated with this gene as a biomarker? | breast cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02186","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is upregulated and is involved in the negative regulation of endo... | |
medium_hidden_intermediate_02187 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Phospholipid metabolism. Experimental evidence for this gene reports a log2 fold change of -1.338 and an adjusted p-value of 0.01452. Which protein is encoded by this gene? | Choline-phosphate cytidylyltransferase B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02187","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Phospholipid metabolism... | |
medium_hidden_intermediate_02188 | Hepacivirus C is reported to downregulate a gene that participates in nucleotide metabolism. In a study of peripheral blood mononuclear cells (GSE119117), one such gene exhibited a log2 fold change of approximately -1.08 and an adjusted p-value of 0.0053. Which protein is encoded by this specific gene? | Adenylate kinase 4, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02188","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that participates in nucleotide metabolism. In a study of peripheral blood ... | |
medium_hidden_intermediate_02190 | Human alphaherpesvirus 1 upregulates a specific gene that participates in HCMV Late Events. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately 1.90 and an adjusted p-value of approximately 0.022. Which protein is encoded by this gene? | Histone H2A type 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02190","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a specific gene that participates in HCMV Late Events. Experimental data for this gene ... | |
medium_hidden_intermediate_02191 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that interacts with NCOR1. Evidence for one such gene reports a log2 fold change of -1.524 and an adjusted p-value of 0.0002888. Which protein is encoded by that gene? | Bromodomain adjacent to zinc finger domain protein 1A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02191","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that interacts with NCOR1. Evidence for one such ... | |
medium_hidden_intermediate_02192 | Zika virus upregulates a gene that participates in the metabolism of amino acids and derivatives. Evidence for this specific gene reports a log2 fold change of 1.275 and an adjusted p-value of 0.03906. Which molecular function is enabled by this gene? | polyamine oxidase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02192","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that participates in the metabolism of amino acids and derivatives. Evidence for this specific... | |
medium_hidden_intermediate_02194 | In a study of Measles morbillivirus infection, the virus upregulates certain genes that subsequently interact with SRPK2. One such gene exhibits a log2 fold change of approximately 1.38 and an adjusted p-value of 0.003886. Which protein is encoded by this specific gene? | Dual specificity protein kinase CLK3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02194","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, the virus upregulates certain genes that subsequently interact with SRPK2. On... | |
medium_hidden_intermediate_02196 | Measles morbillivirus upregulates a gene that interacts with DYRK1B. One such gene exhibits a log2 fold change of 2.978 and an adjusted p-value of 5.959e-05 in pleural mesothelioma cells. Which cell type is this gene enriched in? | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02196","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that interacts with DYRK1B. One such gene exhibits a log2 fold change of 2.978 and ... | |
medium_hidden_intermediate_02197 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in 3'-UTR-mediated mRNA destabilization. Evidence for this gene reports a log2 fold change of 3.663 and an adjusted p-value of 0.008239. Which protein is encoded by this gene? | Pleckstrin homology domain-containing family N member 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02197","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in 3'-UTR-mediated mRNA destabiliz... | |
medium_hidden_intermediate_02201 | IL23A is involved in a biological process that is a subtype of positive regulation of cytokine production. Evidence regarding one such process states: 'while comparing IFN-gamma and IL-10 production in response to IL-23 and IL-12, we found IL-23 to be a more potent IL-10 inducer.' Which biological process is positively... | interleukin-10 production | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02201","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"IL23A is involved in a biological process that is a subtype of positive regulation of cytokine production. Evidence regardin... | |
medium_hidden_intermediate_02202 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and interacting with ACE2 was found to have a log2 fold change of 2.191 and an adjusted p-value of 1.651e-05. Which disease is associated with this gene as a biomarker? | Mesothelioma, malignant | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02202","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and interacting with ACE2 ... | |
medium_hidden_intermediate_02204 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a specific gene product that is localized to the perinuclear endoplasmic reticulum. This entity exhibited a log2 fold change of approximately 1.605 and an adjusted p-value of 4.453e-10. Which protein is encoded by t... | CDGSH iron-sulfur domain-containing protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02204","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a specific gene pro... | |
medium_hidden_intermediate_02206 | Two genes are upregulated by Vaccinia virus and are located in the spindle microtubule. One of these genes exhibits a log2 fold change of 1.107 and an adjusted p-value of 0.0413 in cervical adenocarcinoma cell lines. Which disease is associated with genomic alterations in this specific gene? | juvenile myoclonic epilepsy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02206","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and are located in the spindle microtubule. One of these genes exhibits a log2 f... | |
medium_hidden_intermediate_02207 | In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to downregulate a specific gene, which in turn interacts with MYC. This gene exhibited a log2 fold change of approximately -2.05 and an adjusted p-value of 0.0013. Which protein is encoded by this gene? | DNA-binding protein inhibitor ID-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02207","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to down... | |
medium_hidden_intermediate_02208 | Zaire ebolavirus upregulates a gene that is associated with cervical cancer. Evidence for this gene in retinal pigment epithelium cells (study GSE100839) reports a log2 fold change of approximately 1.578 and an adjusted p-value of 0.01083. Which protein is encoded by this gene? | Interleukin-15 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02208","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus upregulates a gene that is associated with cervical cancer. Evidence for this gene in retinal pigment epith... | |
medium_hidden_intermediate_02214 | Two genes are downregulated by Pegivirus C and are involved in chromatin looping. One of these genes exhibits a log2 fold change of approximately -1.665 and an adjusted p-value of 0.0001273 in peripheral blood mononuclear cells. Which protein interacts with this specific gene product? | PJA1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02214","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and are involved in chromatin looping. One of these genes exhibits a log2 fold ch... | |
medium_hidden_intermediate_02216 | Two genes are upregulated by Vaccinia virus and enriched in peripheral blood mononuclear cells. One of these genes has a reported log2 fold change of 2.876 and an adjusted p-value of 1.368e-06 in cervical adenocarcinoma cell lines. Which protein is encoded by this specific gene? | Neurogranin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02216","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and enriched in peripheral blood mononuclear cells. One of these genes has a rep... | |
medium_hidden_intermediate_02217 | Zika virus downregulates a specific gene that is involved in the positive regulation of the MAPK cascade. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -1.30 and an adjusted p-value of approximately 0.045. Which disease is associated with this gene as a biomarker? | lung cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02217","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is involved in the positive regulation of the MAPK cascade. In a study of glio... | |
medium_hidden_intermediate_02218 | Rhinovirus A infection leads to the downregulation of certain membrane-associated genes. One such gene, identified in cytotoxic T-lymphocytes from study GSE106475, exhibits a log2 fold change of approximately -1.19 and an adjusted p-value of approximately 0.0027. What molecular function is enabled by this specific gene... | signaling receptor binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02218","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection leads to the downregulation of certain membrane-associated genes. One such gene, identified in cytoto... | |
medium_hidden_intermediate_02219 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in phosphatidylserine acyl-chain remodeling. Evidence for one such gene reports a log2 fold change of 1.874 and an adjusted p-value of 0.04109. Which protein is encoded by that gene? | Membrane-bound glycerophospholipid O-acyltransferase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02219","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in phosphatidylserine acyl-chain r... | |
medium_hidden_intermediate_02220 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Class I MHC mediated antigen processing & presentation. Experimental data for this gene reports a log2 fold change of 1.138 and an adjusted p-value of 0.04188. Which cellular component is this gene located in? | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02220","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Class I MHC mediated anti... | |
medium_hidden_intermediate_02221 | A gene serves as a marker for microglial cells and is also enriched in eosinophils. Evidence for one such gene reports a mean expression of 171.85 TPM, a z-score of 2.06, and a fold enrichment of 4.73. Which disease is associated with that specific gene? | myeloid leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02221","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for microglial cells and is also enriched in eosinophils. Evidence for one such gene reports a mea... | |
medium_hidden_intermediate_02222 | Pegivirus C is reported to downregulate a gene that enables GTPase activator activity. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.825 and an adjusted p-value of 0.0002679. Which protein is encoded by this specific gene? | Ras GTPase-activating-like protein IQGAP1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02222","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that enables GTPase activator activity. In a study of peripheral blood mononu... | |
medium_hidden_intermediate_02224 | Zaire ebolavirus upregulates a gene that is involved in the innate immune response. Evidence for this gene in retinal pigment epithelium cells (study GSE100839) shows a log2 fold change of 5.077 and an adjusted p-value of 1.351e-05. Which disease is associated with this gene as a biomarker? | gastric carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02224","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus upregulates a gene that is involved in the innate immune response. Evidence for this gene in retinal pigmen... | |
medium_hidden_intermediate_02226 | Zika virus downregulates a gene that interacts with CDC42. In a study of glioma stem cells (GSE114907), one such gene exhibits a log2 fold change of -1.338 and an adjusted p-value of 0.004134. Which protein is encoded by this gene? | Golgi resident protein GCP60 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02226","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with CDC42. In a study of glioma stem cells (GSE114907), one such gene exhibi... | |
medium_hidden_intermediate_02227 | Zika virus downregulates a gene that subsequently binds to UBE2M. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of approximately -1.26 and an adjusted p-value of approximately 0.047. Which protein is encoded by this specific gene? | F-box/LRR-repeat protein 12 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02227","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that subsequently binds to UBE2M. In a study of glioma stem cells (GSE114907), one such gene... | |
medium_hidden_intermediate_02228 | Hepacivirus C infection is associated with the upregulation of specific genes whose products are located in the cytosol. One such gene exhibits a log2 fold change of 1.610 and an adjusted p-value of 0.02352 in peripheral blood mononuclear cells. Which protein is encoded by this gene? | Caspase-4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02228","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C infection is associated with the upregulation of specific genes whose products are located in the cytosol. One... | |
medium_hidden_intermediate_02229 | Influenza A virus upregulates a specific gene that participates in MAPK family signaling cascades. Experimental data for this gene indicates a log2 fold change of approximately 1.058 and an adjusted p-value of 0.0009554. Which cell type is this gene enriched in? | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02229","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Influenza A virus upregulates a specific gene that participates in MAPK family signaling cascades. Experimental data for thi... | |
medium_hidden_intermediate_02230 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and binds to MRPS21. This specific gene exhibits a log2 fold change of 2.697 and an adjusted p-value of 4.709e-11. Which protein is encoded by this gene? | Large ribosomal subunit protein bL36m | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02230","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and binds to MRPS21. Th... | |
medium_hidden_intermediate_02231 | Two distinct drugs are known to interact with both Calcitriol (topical) and Lapatinib. One of these drugs is an androgen, and evidence suggests that administering it concurrently with Vitamin D at physiologic levels may offer a superior alternative for arresting castration-resistant prostate cancer (CRPC). What disease... | hypogonadotropic hypogonadism | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02231","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct drugs are known to interact with both Calcitriol (topical) and Lapatinib. One of these drugs is an androgen, an... | |
medium_hidden_intermediate_02232 | Hepacivirus C is reported to upregulate a gene that is located in the lysosomal membrane. Evidence for one such gene reports a log2 fold change of 1.344 and an adjusted p-value of 0.04701. Which protein is encoded by that gene? | Solute carrier family 2, facilitated glucose transporter member 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02232","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to upregulate a gene that is located in the lysosomal membrane. Evidence for one such gene reports... | |
medium_hidden_intermediate_02234 | Two genes are structurally linked from Hepacivirus C via a downregulation relationship and subsequently to non-classical monocytes via an enrichment relationship. One of these genes is reported in study GSE119117 with a log2 fold change of -2.276 and an adjusted p-value of 0.01903. Which biological process is this spec... | endothelial cell migration | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02234","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Hepacivirus C via a downregulation relationship and subsequently to non-classical mon... | |
medium_hidden_intermediate_02235 | In a study of Measles morbillivirus infection, multiple genes are downregulated and subsequently linked to the function of transmembrane transporter binding. One such gene exhibits a log2 fold change of -2.136 and an adjusted p-value of 0.004195. Which protein is encoded by this specific gene? | A-type potassium channel modulatory protein KCNIP2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02235","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, multiple genes are downregulated and subsequently linked to the function of t... | |
medium_hidden_intermediate_02237 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with RPAP3. One of these genes exhibits a log2 fold change of approximately 1.95 and an adjusted p-value of 0.01028 in a specific study. Which protein is encoded by this gene? | PH domain leucine-rich repeat-containing protein phosphatase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02237","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with RPAP3. One of these gen... | |
medium_hidden_intermediate_02238 | Two genes are upregulated by Human immunodeficiency virus 1 and bind to PEX5. One of these genes exhibits a log2 fold change of 1.821 and an adjusted p-value of 0.01083 in macrophages. Which disease is associated with this specific gene as a biomarker? | hypertensive disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02238","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and bind to PEX5. One of these genes exhibits a log2 fold change... | |
medium_hidden_intermediate_02239 | Human immunodeficiency virus 1 downregulates a gene that interacts with MAPK1. Evidence for this gene in a specific study (GSE108897) reports a log2 fold change of approximately -1.03 and an adjusted p-value of approximately 0.0096. In which cell type is this gene enriched? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02239","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that interacts with MAPK1. Evidence for this gene in a specific study (G... | |
medium_hidden_intermediate_02240 | Hepacivirus C is reported to upregulate a gene that subsequently interacts with DYNLL1. One such gene exhibits a log2 fold change of 1.094 and an adjusted p-value of 0.004307 in liver cells. Which protein is encoded by this specific gene? | Zinc finger protein 608 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02240","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to upregulate a gene that subsequently interacts with DYNLL1. One such gene exhibits a log2 fold c... | |
medium_hidden_intermediate_02242 | In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to downregulate a gene that participates in Glycosphingolipid catabolism. One such gene exhibited a log2 fold change of -1.957 and an adjusted p-value of 0.0009837. Which protein is encoded by this speci... | Beta-galactosidase-1-like protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02242","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to down... | |
medium_hidden_intermediate_02243 | Floor plate morphogenesis is a subtype of a specific biological process, which is itself a subtype of anatomical structure morphogenesis. Evidence for this intermediate process states: 'The process in which the anatomical structure of the floor plate is generated and organized.' Which biological process is this interme... | embryo development | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02243","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Floor plate morphogenesis is a subtype of a specific biological process, which is itself a subtype of anatomical structure m... | |
medium_hidden_intermediate_02244 | Two genes are downregulated by Human immunodeficiency virus 1 and associated with lung carcinoma. One of these genes exhibits a log2 fold change of approximately -1.205 and an adjusted p-value of 0.008818 in macrophages (study GSE108897). Which disease is linked to this specific gene through genomic alterations? | clear cell renal carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02244","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Human immunodeficiency virus 1 and associated with lung carcinoma. One of these genes exhibit... | |
medium_hidden_intermediate_02247 | Zika virus downregulates a specific gene, which in turn binds to RPS28. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -1.187 and an adjusted p-value of 0.02901. Which protein is encoded by this gene? | Eukaryotic translation initiation factor 3 subunit D | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02247","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn binds to RPS28. Experimental data for this gene in glioma stem cells... | |
medium_hidden_intermediate_02248 | Two genes are each downregulated by Human immunodeficiency virus 1 and associated with neuroblastoma. One of these genes exhibits a log2 fold change of -1.056 and an adjusted p-value of 0.02949 in macrophages (study GSE108897). Which gene interacts with the gene identified by these expression statistics? | NPTX2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02248","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each downregulated by Human immunodeficiency virus 1 and associated with neuroblastoma. One of these genes exh... | |
medium_hidden_intermediate_02249 | A gene is upregulated by Primate bocaparvovirus 1 and serves as a biomarker for stroke disorder. Evidence for this gene reports a log2 fold change of approximately 1.20 and an adjusted p-value of approximately 0.033. Which cellular component is this gene located in? | peroxisome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02249","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and serves as a biomarker for stroke disorder. Evidence for this gene repo... | |
medium_hidden_intermediate_02250 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is located in the immunological synapse. Experimental evidence for this gene reports a log2 fold change of 1.980 and an adjusted p-value of 0.0269. Which disease is associated with this gene as a biomarker? | familial glucocorticoid deficiency | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02250","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is located in the immunological synapse. ... | |
medium_hidden_intermediate_02252 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with HOOK3. One such gene exhibits a log2 fold change of approximately 4.199 and an adjusted p-value of 4.868e-05 in lung tissue. Which molecular function is enabled by this specific gene? | signaling receptor binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02252","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with HOOK3. One such gene exhibits a... | |
medium_hidden_intermediate_02253 | Pegivirus C is reported to downregulate a specific gene, which in turn interacts with PLK1. Experimental data for this intermediate gene in peripheral blood mononuclear cells (from study GSE131504) shows a log2 fold change of approximately -1.101 and an adjusted p-value of 0.03571. What protein is encoded by this gene? | Myosin phosphatase Rho-interacting protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02253","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn interacts with PLK1. Experimental data for this inter... | |
medium_hidden_intermediate_02254 | Hepacivirus C is linked to gallbladder carcinoma via the upregulation of a specific gene. Experimental data for this gene reports a log2 fold change of 1.471 and an adjusted p-value of 0.004576. Which protein is encoded by this gene? | Tissue factor pathway inhibitor 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02254","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is linked to gallbladder carcinoma via the upregulation of a specific gene. Experimental data for this gene re... | |
medium_hidden_intermediate_02256 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is located in the apical plasma membrane. Transcriptomic data for this gene reports a log2 fold change of 4.893 and an adjusted p-value of 0.01303. Which molecular function is enabled by this gene? | sodium:bicarbonate symporter activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02256","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is located in the apical plasma membrane.... | |
medium_hidden_intermediate_02258 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with melanoma. One of these genes has a reported log2 fold change of approximately 1.27 and an adjusted p-value of approximately 0.017. Which cell type is this specific gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02258","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with melanoma. One of ... | |
medium_hidden_intermediate_02259 | Human betaherpesvirus 5 upregulates a gene that participates in phospholipid metabolism. Evidence for one such gene reports a log2 fold change of 1.125 and an adjusted p-value of 0.002221. Which disease is associated with that gene? | mitochondrial myopathy-lactic acidosis-deafness syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02259","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that participates in phospholipid metabolism. Evidence for one such gene reports ... | |
medium_hidden_intermediate_02260 | Two distinct drugs are known to interact with both Phenytoin and Rucaparib. One of these drugs is associated with evidence stating: 'Clinically significant drug interactions have been reported to occur when paclitaxel is administered with doxorubicin, cisplatin, or anticonvulsants (phenytoin, carbamazepine, and phenoba... | head and neck cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02260","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct drugs are known to interact with both Phenytoin and Rucaparib. One of these drugs is associated with evidence s... | |
medium_hidden_intermediate_02261 | In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and participates in developmental biology processes. Transcriptomic data for this gene shows a log2 fold change of approximately 2.98 and an adjusted p-value of approximately 0.0315. Which protein is encoded by this gene? | Docking protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02261","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and participates in developmental... | |
medium_hidden_intermediate_02262 | Two distinct genes, both interacting with SIN3A and COPS2, are potential intermediates in this pathway. One of these gene products is described as a native subunit of a repressive mSin3a-HDAC1 histone deacetylase complex that binds with high affinity to trimethylated species. Which protein is encoded by the gene corres... | Inhibitor of growth protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02262","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct genes, both interacting with SIN3A and COPS2, are potential intermediates in this pathway. One of these gene pr... | |
medium_hidden_intermediate_02263 | In a study of peripheral blood mononuclear cells (GSE131504), a gene is identified that is downregulated by Pegivirus C and participates in Sensory Perception. This specific gene exhibits a log2 fold change of -1.163 and an adjusted p-value of 0.02855. Which protein is encoded by this gene? | Carotenoid-cleaving dioxygenase, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02263","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of peripheral blood mononuclear cells (GSE131504), a gene is identified that is downregulated by Pegivirus C and ... | |
medium_hidden_intermediate_02264 | Two genes are upregulated by Human immunodeficiency virus 1 and are enriched in Regulatory T (Treg) cells. One of these genes exhibits a log2 fold change of 1.122 and an adjusted p-value of 0.005739 in macrophages (study GSE108897). Which molecular function is enabled by this specific gene? | [heparan sulfate]-glucosamine 3-sulfotransferase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02264","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and are enriched in Regulatory T (Treg) cells. One of these gene... | |
medium_hidden_intermediate_02265 | Measles morbillivirus upregulates a gene that participates in infectious disease. Experimental data for this gene shows a log2 fold change of approximately 1.25 and an adjusted p-value of approximately 7.12e-05. Which protein is encoded by this gene? | Nucleoporin NDC1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02265","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that participates in infectious disease. Experimental data for this gene shows a lo... | |
medium_hidden_intermediate_02266 | Human alphaherpesvirus 1 downregulates a gene that is involved in cell adhesion. Evidence for one such gene reports a log2 fold change of -1.609 and an adjusted p-value of 0.00185. Which disease is associated with this gene as a biomarker? | thyroid tumor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02266","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 downregulates a gene that is involved in cell adhesion. Evidence for one such gene reports a log2 f... | |
medium_hidden_intermediate_02267 | An anatomical entity is defined as a pedal digit metatarsal endochondral element, which is a type of limb endochondral element. Evidence for this entity describes it as 'A pedal digit metatarsal bone or its cartilage or pre-cartilage precursor.' Which anatomical structure is this entity a part of? | autopodial skeleton | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02267","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"An anatomical entity is defined as a pedal digit metatarsal endochondral element, which is a type of limb endochondral eleme... | |
medium_hidden_intermediate_02268 | Pegivirus C is reported to downregulate a gene that is involved in intracellular iron ion homeostasis. Evidence for this specific gene in peripheral blood mononuclear cells (from study GSE131504) shows a log2 fold change of -1.092 and an adjusted p-value of 0.005934. Which protein is encoded by this gene? | Cytosolic Fe-S cluster assembly factor NUBP1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02268","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in intracellular iron ion homeostasis. Evidence for this spe... | |
medium_hidden_intermediate_02269 | In a study of glioma stem cells (GSE114907), a gene downregulated by Zika virus that enables zinc ion binding was found to have a log2 fold change of approximately -1.35 and an adjusted p-value of 0.0143. Which protein does this specific gene interact with? | ALDH4A1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02269","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), a gene downregulated by Zika virus that enables zinc ion binding was found to h... |
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