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medium_hidden_intermediate_02270 | In a study of bronchial epithelial cells (GSE150819), Severe acute respiratory syndrome-related coronavirus was found to upregulate a gene that participates in the Pentose phosphate pathway. One such gene exhibited a log2 fold change of approximately 1.307 and an adjusted p-value of 0.02458. Which biological process is... | nucleobase-containing compound metabolic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02270","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of bronchial epithelial cells (GSE150819), Severe acute respiratory syndrome-related coronavirus was found to upr... | |
medium_hidden_intermediate_02271 | Hepacivirus C is reported to downregulate a gene that subsequently binds to GNG2. Among the genes fitting this structural description, one exhibits a log2 fold change of approximately -1.344 and an adjusted p-value of 4.883e-05 in natural killer cells. Which cell type is this specific gene enriched in? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02271","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that subsequently binds to GNG2. Among the genes fitting this structural de... | |
medium_hidden_intermediate_02272 | A specific genetic variant, NM_015600.4(ABHD12):c.-6898_191+7002delinsCC, is associated with a gene that interacts with STK4. Evidence indicates that the protein product of this gene binds MST1 through its carboxyl-terminal segment. Which protein is encoded by this gene? | 52 kDa repressor of the inhibitor of the protein kinase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02272","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A specific genetic variant, NM_015600.4(ABHD12):c.-6898_191+7002delinsCC, is associated with a gene that interacts with STK4... | |
medium_hidden_intermediate_02275 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of specific genes involved in the negative regulation of transcription by RNA polymerase II. One such gene exhibits a log2 fold change of approximately -1.54 and an adjusted p-value of 0.0183. Which protein... | Interleukin-33 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02275","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of specifi... | |
medium_hidden_intermediate_02277 | A gene is downregulated by Hepacivirus C and enriched in classical monocytes. Evidence for this gene reports a log2 fold change of approximately -1.27 and an adjusted p-value of approximately 0.027. Which disease is associated with this gene as a biomarker? | ovarian adenocarcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02277","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Hepacivirus C and enriched in classical monocytes. Evidence for this gene reports a log2 fold cha... | |
medium_hidden_intermediate_02278 | In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to downregulate a gene that is associated with leukemia. One such gene exhibited a log2 fold change of -1.442 and an adjusted p-value of 0.005651. Which protein is encoded by this specific gene? | Cyclin-dependent kinase inhibitor 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02278","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to down... | |
medium_hidden_intermediate_02279 | Two genes are structurally linked to IL20 via a 'binds' interaction and subsequently linked to the molecular function 'protein binding' via an 'enables' relationship. One of these genes is characterized by a signaling mechanism involving the sequential binding of IL-22 to interleukin-22 receptor 1 (IL-22R1), followed b... | mammary neoplasms, animal | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02279","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to IL20 via a 'binds' interaction and subsequently linked to the molecular function 'prote... | |
medium_hidden_intermediate_02281 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and subsequently interacts with NRAS. Experimental data for this gene reports a log2 fold change of approximately 1.553 and an adjusted p-value of 0.01916. Which protein is encoded by this gene? | Cdc42 effector protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02281","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and subsequent... | |
medium_hidden_intermediate_02282 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and binds to GNA14. Experimental data for this gene reports a log2 fold change of 1.444 and an adjusted p-value of 0.005759. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02282","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and binds to GNA14. Experimental data for thi... | |
medium_hidden_intermediate_02284 | A gene is upregulated by Vaccinia virus and participates in a disease process. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately 1.251 and an adjusted p-value of approximately 1.452e-07. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02284","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Vaccinia virus and participates in a disease process. Experimental data for this gene in a cervical... | |
medium_hidden_intermediate_02285 | In a study of cervical adenocarcinoma cells (GSE11238), a gene downregulated by Vaccinia virus and known to enable identical protein binding exhibits a log2 fold change of approximately -1.19 and an adjusted p-value of 0.0006. Which biological process is this gene involved in? | regulation of transcription by RNA polymerase II | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02285","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), a gene downregulated by Vaccinia virus and known to enable identical... | |
medium_hidden_intermediate_02287 | Pegivirus C downregulates a specific gene, which is enriched in gamma-delta (γδ) T cells. Evidence for this gene in peripheral blood mononuclear cells reports a log2 fold change of approximately -1.32 and an adjusted p-value of approximately 0.024. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02287","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a specific gene, which is enriched in gamma-delta (γδ) T cells. Evidence for this gene in peripher... | |
medium_hidden_intermediate_02289 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and subsequently to 'positive regulation of canonical NF-kappaB signal transduction' via an 'involved in' relationship. One of these genes is associated with experimental evidence showing a log2... | SYT1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02289","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_02290 | Zika virus infection has been linked to the upregulation of specific genes, which are in turn associated with pituitary gland adenoma. One such gene exhibits a log2 fold change of 3.075 and an adjusted p-value of 0.006947 in neural stem cells. Which protein is encoded by this gene? | Ciliary neurotrophic factor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02290","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection has been linked to the upregulation of specific genes, which are in turn associated with pituitary glan... | |
medium_hidden_intermediate_02291 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with RPN1. Transcriptomic data for this gene shows a log2 fold change of approximately 1.069 and an adjusted p-value of 0.006421. In which cell type is this gene enriched? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02291","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with RPN1. Transcriptomic data ... | |
medium_hidden_intermediate_02292 | Two genes are upregulated by Vaccinia virus and are associated with childhood acute lymphoblastic leukemia via genomic alterations. One of these genes exhibits a log2 fold change of approximately 1.806 and an adjusted p-value of 7.424e-06 in cervical adenocarcinoma cell lines (study GSE11238). Which protein interacts w... | CLPP | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02292","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and are associated with childhood acute lymphoblastic leukemia via genomic alter... | |
medium_hidden_intermediate_02294 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and both enable protein-lysine N-methyltransferase activity. One of these genes shows a log2 fold change of 1.100 and an adjusted p-value of 0.000446 in a specific study. Which disease is associated with this specific gene as a biomarker... | breast carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02294","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and both enable protein-lysine N-methyltr... | |
medium_hidden_intermediate_02295 | Hepacivirus C upregulates a gene that is involved in the negative regulation of DNA-templated transcription. Experimental data for one such gene reports a log2 fold change of 1.162 and an adjusted p-value of 0.007041. Which gene interacts with this specific upregulated gene? | ZBTB2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02295","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in the negative regulation of DNA-templated transcription. Experimental da... | |
medium_hidden_intermediate_02297 | Zika virus downregulates a gene that is associated with colitis. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.37 and an adjusted p-value of 0.00678. Which protein is encoded by this gene? | Developmentally-regulated GTP-binding protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02297","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is associated with colitis. Experimental data for this gene in glioma stem cells (study... | |
medium_hidden_intermediate_02298 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and to fetal alcohol syndrome via an 'associated with' relationship. One of these genes is reported in a study (GSE153218) involving bronchial epithelial cell lines, with a log2 fold change of ap... | extracellular space | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02298","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship... | |
medium_hidden_intermediate_02299 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in cell adhesion. Evidence for one such gene reports a log2 fold change of 1.666 and an adjusted p-value of 0.02833. Which protein does this gene interact with? | CHMP3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02299","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in cell adhesion. Evidence for one... | |
medium_hidden_intermediate_02300 | Human alphaherpesvirus 1 upregulates a gene that is located in the cytoplasm. Evidence for one such gene reports a log2 fold change of 1.029 and an adjusted p-value of 0.02292. Which disease is associated with this gene as a biomarker? | thyroid gland carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02300","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that is located in the cytoplasm. Evidence for one such gene reports a log2 fold... | |
medium_hidden_intermediate_02302 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that enables zinc ion binding. Evidence for this gene reports a log2 fold change of -1.884 and an adjusted p-value of 0.02455. Which biological process is this gene involved in? | negative regulation of metallopeptidase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02302","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that enables zinc ion binding. Evidence for this ... | |
medium_hidden_intermediate_02304 | Two genes are downregulated by Pegivirus C and interact with YWHAB. One of these genes exhibits a log2 fold change of approximately -1.223 and an adjusted p-value of 0.01669 in peripheral blood mononuclear cells. Which disease is associated with genomic alterations in this specific gene? | depressive disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02304","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and interact with YWHAB. One of these genes exhibits a log2 fold change of approx... | |
medium_hidden_intermediate_02305 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to downregulate a specific gene, which in turn enables protein kinase binding. This gene exhibited a log2 fold change of approximately -1.248 and an adjusted p-value of 0.04295. Which protein is encoded by this gene? | Mitogen-activated protein kinase kinase kinase 12 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02305","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to downregulate a specific gene, which i... | |
medium_hidden_intermediate_02306 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 downregulates a gene that is involved in the response to endoplasmic reticulum stress. This specific gene exhibits a log2 fold change of -2.798 and an adjusted p-value of 0.001842. Which protein is encoded by this gene? | Secretory carrier-associated membrane protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02306","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 downregulates a gene that is involved in the response ... | |
medium_hidden_intermediate_02307 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that interacts with CLPP. Evidence for one such gene reports a log2 fold change of -1.108 and an adjusted p-value of 0.0003262. Which protein is encoded by that gene? | Oxidized purine nucleoside triphosphate hydrolase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02307","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that interacts with CLPP. Evidence for one such g... | |
medium_hidden_intermediate_02308 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate genes involved in the positive regulation of mitochondrial fission. One such gene exhibited a log2 fold change of approximately 1.22 and an adjusted p-value of approximately 0.0043. Which protein is encoded by ... | Mitochondrial dynamics protein MIEF1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02308","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate genes involved... | |
medium_hidden_intermediate_02309 | Hepacivirus C is reported to downregulate a gene that participates in triglyceride biosynthesis. Experimental data for one such gene shows a log2 fold change of approximately -1.37 and an adjusted p-value of 0.0062. Which protein is encoded by this specific gene? | Phosphatidate phosphatase LPIN3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02309","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that participates in triglyceride biosynthesis. Experimental data for one s... | |
medium_hidden_intermediate_02310 | Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to 'positive regulation of transcription by RNA polymerase II' via an 'involved in' relationship. One of these genes exhibits a log2 fold change of -1.144 and an adjusted p-value of 0.01271 in a specific study. Wh... | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02310","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to 'positive regu... | |
medium_hidden_intermediate_02312 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Ub-specific processing proteases activity. Experimental data for this gene in lung cells shows a log2 fold change of approximately 1.093 and an adjusted p-value of 0.00154. Which disease is associated with this gene? | carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02312","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Ub-specific processing pr... | |
medium_hidden_intermediate_02313 | Pegivirus C is reported to downregulate a gene that is involved in the endoplasmic reticulum unfolded protein response. Evidence for this specific gene shows a log2 fold change of approximately -1.68 and an adjusted p-value of 0.0016. Which cell type is this gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02313","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in the endoplasmic reticulum unfolded protein response. Evid... | |
medium_hidden_intermediate_02315 | Two genes are structurally linked to Hepacivirus C via a 'downregulates' relationship and to sequence-specific double-stranded DNA binding via an 'enables' relationship. One of these genes has a reported log2 fold change of -1.754 and an adjusted p-value of 0.01857 in peripheral blood mononuclear cells. Which disease i... | colon carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02315","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Hepacivirus C via a 'downregulates' relationship and to sequence-specific double-strand... | |
medium_hidden_intermediate_02316 | In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to downregulate a gene involved in central nervous system development. One such gene exhibited a log2 fold change of -1.164 and an adjusted p-value of 0.0289. Which protein is encoded by this specific ge... | POU domain, class 6, transcription factor 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02316","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to down... | |
medium_hidden_intermediate_02318 | Human betaherpesvirus 5 upregulates a gene that participates in the metabolism of lipids. Evidence for one such gene reports a log2 fold change of 1.132 and an adjusted p-value of 0.0001445. Which disease is associated with this gene as a biomarker? | prostate carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02318","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that participates in the metabolism of lipids. Evidence for one such gene reports... | |
medium_hidden_intermediate_02319 | Two genes are structurally linked to Pegivirus C via downregulation and to G alpha (q) signalling events via participation. One of these genes exhibits a log2 fold change of -1.449 and an adjusted p-value of 0.003727 in peripheral blood mononuclear cells. Which cell type is enriched for this specific gene? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02319","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Pegivirus C via downregulation and to G alpha (q) signalling events via participation. ... | |
medium_hidden_intermediate_02320 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables triacylglycerol lipase activity. Evidence for this gene reports a log2 fold change of 1.518 and an adjusted p-value of 0.006733. Which protein is encoded by this gene? | Diacylglycerol lipase-beta | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02320","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables triacylglycerol lipase activity. ... | |
medium_hidden_intermediate_02321 | Zika virus downregulates a specific gene, which in turn interacts with RB1CC1. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -2.24 and an adjusted p-value of approximately 0.0026. Which cellular component is this gene located in? | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02321","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with RB1CC1. Experimental data for this gene in glioma ste... | |
medium_hidden_intermediate_02322 | Enterovirus A upregulates a specific gene that participates in the epigenetic regulation of gene expression. In a study of rhabdomyosarcoma cells (GSE103308), this gene exhibited a log2 fold change of 1.843 and an adjusted p-value of 0.01422. Which protein is encoded by this gene? | Zinc finger protein 382 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02322","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A upregulates a specific gene that participates in the epigenetic regulation of gene expression. In a study of r... | |
medium_hidden_intermediate_02323 | In a study of macrophages (GSE108897), a gene is downregulated by Human immunodeficiency virus 1 and binds to XIAP. This gene exhibits a log2 fold change of -3.111 and an adjusted p-value of 0.02632. Which protein is encoded by this gene? | Repulsive guidance molecule B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02323","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is downregulated by Human immunodeficiency virus 1 and binds to XIAP. This gen... | |
medium_hidden_intermediate_02325 | NEUROG1 is involved in a biological process that is part of inner ear development. One such process is defined as the generation and organization of the anatomical structures of the inner ear, which includes the membranous labyrinth, bony labyrinth, sacculus, utriculus, cochlea, and semicircular canals. Which biologica... | embryonic morphogenesis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02325","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"NEUROG1 is involved in a biological process that is part of inner ear development. One such process is defined as the genera... | |
medium_hidden_intermediate_02326 | Human immunodeficiency virus 1 downregulates a gene that is associated with carcinoma. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately -1.23 and an adjusted p-value of approximately 0.0034. Which biological process is this gene involved in? | L-methionine salvage from methylthioadenosine | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02326","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is associated with carcinoma. In a study of macrophages (GSE108897)... | |
medium_hidden_intermediate_02327 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are located in extracellular vesicles. One of these genes exhibits a log2 fold change of approximately 4.04 and an adjusted p-value of approximately 0.0071 in a specific study. Which protein interacts with this specific gene? | PRNP | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02327","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are located in extracellular vesicles... | |
medium_hidden_intermediate_02328 | In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and is involved in protein dephosphorylation. This specific gene exhibits a log2 fold change of approximately 1.01 and an adjusted p-value of 0.031. Which protein does this gene interact with? | TK1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02328","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and is involved... | |
medium_hidden_intermediate_02329 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to head and neck squamous cell carcinoma via a biomarker relationship. One of these genes is associated with a log2 fold change of 2.214 and an adjusted p-value of 0.01964. Which protein is encoded by this... | F-box only protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02329","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to head a... | |
medium_hidden_intermediate_02330 | Human alphaherpesvirus 1 upregulates a gene that is located in the extracellular matrix. Evidence for this specific gene reports a log2 fold change of 1.142 and an adjusted p-value of 0.02168. Which protein is encoded by this gene? | Tetraspanin-9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02330","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that is located in the extracellular matrix. Evidence for this specific gene rep... | |
medium_hidden_intermediate_02331 | Hepacivirus C upregulates a gene that enables alpha-tubulin binding. Evidence for one such gene reports a log2 fold change of 1.925 and an adjusted p-value of 0.03634. Which protein is encoded by that gene? | ADP-ribosylation factor-like protein 8A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02331","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that enables alpha-tubulin binding. Evidence for one such gene reports a log2 fold change o... | |
medium_hidden_intermediate_02332 | Hepacivirus C upregulates a gene that participates in the Generic Transcription Pathway. Experimental data for this gene shows a log2 fold change of approximately 1.28 and an adjusted p-value of approximately 6.07e-05. In which cellular component is this gene product located? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02332","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in the Generic Transcription Pathway. Experimental data for this gene sho... | |
medium_hidden_intermediate_02333 | Two biological processes are hierarchically situated between 'metanephric nephron tubule development' and 'metanephric epithelium development' via 'is a' relationships. One of these intermediate processes is described by the evidence: 'The progression of a metanephric nephron tubule over time, from its initial formatio... | metanephric tubule | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02333","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two biological processes are hierarchically situated between 'metanephric nephron tubule development' and 'metanephric epith... | |
medium_hidden_intermediate_02334 | Human immunodeficiency virus 1 upregulates a gene that participates in O-linked glycosylation. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately 1.214 and an adjusted p-value of 0.0002396. Which disease is associated with this gene? | pulmonary hypertension | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02334","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in O-linked glycosylation. In a study of macrophages (GS... | |
medium_hidden_intermediate_02335 | Two genes are structurally linked from Severe acute respiratory syndrome-related coronavirus via a downregulation relationship and onward to hypogonadotropic hypogonadism 7 with or without anosmia via an association relationship. One of these genes has reported expression data showing a log2 fold change of -1.104 and a... | NMDA receptor synaptonuclear signaling and neuronal migration factor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02335","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Severe acute respiratory syndrome-related coronavirus via a downregulation relationsh... | |
medium_hidden_intermediate_02336 | Zika virus infection leads to the downregulation of certain genes involved in microtubule cytoskeleton organization. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -2.531 and an adjusted p-value of 0.005615. Which protein is encoded by this specific gene? | Cilia- and flagella-associated protein 44 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02336","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection leads to the downregulation of certain genes involved in microtubule cytoskeleton organization. In a st... | |
medium_hidden_intermediate_02337 | Zaire ebolavirus upregulates multiple genes that are located in the extracellular region. One such gene exhibits a log2 fold change of 1.416 and an adjusted p-value of 1.236e-05 in retinal pigment epithelium cells (study GSE100839). Which disease is associated with this specific gene? | lupus vulgaris | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02337","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus upregulates multiple genes that are located in the extracellular region. One such gene exhibits a log2 fold... | |
medium_hidden_intermediate_02338 | Two genes are structurally linked to Cardiovirus A via downregulation and to STK4 via interaction. One of these genes has a reported log2 fold change of -1.429 and an adjusted p-value of 0.02354. Which cell type is this specific gene enriched in? | memory B cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02338","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Cardiovirus A via downregulation and to STK4 via interaction. One of these genes has a ... | |
medium_hidden_intermediate_02341 | Human alphaherpesvirus 3 is reported to downregulate a gene that is located in the lysosomal membrane. In a study of melanoma cell lines (GSE136586), one such gene exhibits a log2 fold change of approximately -1.149 and an adjusted p-value of 0.004707. Which protein is encoded by this specific gene? | Free fatty acid receptor 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02341","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 is reported to downregulate a gene that is located in the lysosomal membrane. In a study of melanom... | |
medium_hidden_intermediate_02342 | Zika virus downregulates a gene that interacts with NFE2L2. Experimental data for one such gene reports a log2 fold change of approximately -1.27 and an adjusted p-value of approximately 0.019. Which protein is encoded by this gene? | Progestin and adipoQ receptor family member 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02342","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with NFE2L2. Experimental data for one such gene reports a log2 fold change o... | |
medium_hidden_intermediate_02343 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate genes involved in the positive regulation of the stress-activated MAPK cascade. One such gene exhibited a log2 fold change of approximately 2.056 and an adjusted p-value of 0.0003081. Which protein is encoded b... | Semaphorin-4C | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02343","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate genes involved... | |
medium_hidden_intermediate_02344 | Zika virus downregulates a gene that interacts with TMPRSS4. In glioma stem cells, one such gene exhibits a log2 fold change of approximately -2.14 and an adjusted p-value of approximately 0.007. Which protein is encoded by this gene? | Chondroitin sulfate glucuronyltransferase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02344","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with TMPRSS4. In glioma stem cells, one such gene exhibits a log2 fold change... | |
medium_hidden_intermediate_02345 | Pegivirus C is reported to downregulate a gene that is involved in the positive regulation of DNA-templated transcription. Experimental data from a study on peripheral blood mononuclear cells (GSE131504) indicates that this specific gene has a log2 fold change of approximately -1.905 and an adjusted p-value of 0.04132.... | TRAF2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02345","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in the positive regulation of DNA-templated transcription. E... | |
medium_hidden_intermediate_02346 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which in turn interacts with CEP135. The expression data for this intermediate gene shows a log2 fold change of approximately -1.284 and an adjusted p-value of 0.01232. Which protein is ... | Centrosomal protein of 95 kDa | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02346","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_02347 | Rhinovirus A infection is linked to the downregulation of specific genes, which are in turn associated with hepatocellular carcinoma. One such gene exhibits a log2 fold change of -1.218 and an adjusted p-value of 2.444e-05 in cytotoxic T-lymphocytes (study GSE106475). Which protein is encoded by this gene? | Epithelial membrane protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02347","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection is linked to the downregulation of specific genes, which are in turn associated with hepatocellular c... | |
medium_hidden_intermediate_02349 | A gene is upregulated by Primate bocaparvovirus 1 and is enriched in basophils. Experimental data for this gene reports a log2 fold change of approximately 1.75 and an adjusted p-value of 0.042. Which protein is encoded by this gene? | Suppressor of cytokine signaling 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02349","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and is enriched in basophils. Experimental data for this gene reports a lo... | |
medium_hidden_intermediate_02350 | Two genes are upregulated by Human immunodeficiency virus 1 and participate in Platelet degranulation. One of these genes exhibits a log2 fold change of approximately 1.62 and an adjusted p-value of approximately 7.12e-05 in a specific study. Which cell type is enriched for this specific gene? | conventional dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02350","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and participate in Platelet degranulation. One of these genes ex... | |
medium_hidden_intermediate_02351 | The protein RYR2 is involved in a biological process that is a subtype of the regulation of cardiac muscle cell action potential. Evidence for one such specific process describes it as any process that modulates the frequency, rate, or extent of action potential creation, propagation, or termination in an SA node cardi... | SA node cell action potential | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02351","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"The protein RYR2 is involved in a biological process that is a subtype of the regulation of cardiac muscle cell action poten... | |
medium_hidden_intermediate_02352 | Human immunodeficiency virus 1 downregulates a gene that participates in Mitotic G2-G2/M phases. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of -1.494 and an adjusted p-value of 0.04482. Which cellular component is this gene located in? | extracellular region | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02352","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in Mitotic G2-G2/M phases. In a study of macrophages (... | |
medium_hidden_intermediate_02353 | A gene serves as a marker for Exhausted CD4+ T cells and is enriched in Regulatory T (Treg) cells. Evidence for this gene includes a mean expression of 7.16 TPM, a z-score of 2.57, and a fold enrichment of 8.99. Which disease is associated with this gene? | uniparental disomy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02353","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for Exhausted CD4+ T cells and is enriched in Regulatory T (Treg) cells. Evidence for this gene in... | |
medium_hidden_intermediate_02354 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the endoplasmic reticulum lumen. Evidence for this specific gene reports a log2 fold change of 1.631 and an adjusted p-value of 3.368e-05. Which protein is encoded by this gene? | Endoplasmic reticulum resident protein 29 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02354","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the endoplasmic reticulum lumen.... | |
medium_hidden_intermediate_02355 | A gene serves as a marker for Exhausted CD8+ T cells and is localized to the plasma membrane. Evidence indicates that this gene product is associated with the plasma membrane as well as intracellular perinuclear and peripheral vesicular structures of myotubes, as revealed by indirect immunofluorescence microscopy and i... | muscle organ development | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02355","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for Exhausted CD8+ T cells and is localized to the plasma membrane. Evidence indicates that this g... | |
medium_hidden_intermediate_02357 | Rhinovirus A infection upregulates a specific gene that participates in the MyD88-independent TLR4 cascade. In cytotoxic T-lymphocytes, this gene exhibits a log2 fold change of approximately 1.228 and an adjusted p-value of 0.0002379. Which cellular component is this gene located in? | cytosol | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02357","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection upregulates a specific gene that participates in the MyD88-independent TLR4 cascade. In cytotoxic T-l... | |
medium_hidden_intermediate_02359 | A gene is downregulated by Measles morbillivirus and participates in Glycerophospholipid biosynthesis. Evidence for this gene reports a log2 fold change of -1.614 and an adjusted p-value of 0.003353. Which disease is connected to this gene through genomic alterations? | intellectual disability | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02359","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Measles morbillivirus and participates in Glycerophospholipid biosynthesis. Evidence for this gen... | |
medium_hidden_intermediate_02362 | Pegivirus C is reported to downregulate a gene that is enriched in conventional dendritic cells. Evidence for one such gene indicates a log2 fold change of -1.665 and an adjusted p-value of 0.01232. Which protein is encoded by this gene? | Homeodomain-interacting protein kinase 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02362","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is enriched in conventional dendritic cells. Evidence for one such gene ... | |
medium_hidden_intermediate_02363 | CIAO1 interacts with a partner protein that is involved in iron-sulfur cluster assembly. Evidence indicates that the CIA1 subunit associates with either CIA2A or a specific partner, as well as the CIA-targeting factor MMS19. Based on this association pattern, which protein is encoded by the gene corresponding to the pa... | Cytosolic iron-sulfur assembly component 2B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02363","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"CIAO1 interacts with a partner protein that is involved in iron-sulfur cluster assembly. Evidence indicates that the CIA1 su... | |
medium_hidden_intermediate_02364 | Human alphaherpesvirus 1 upregulates a gene that participates in RNA Polymerase II Transcription. Evidence for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately 1.216 and an adjusted p-value of 0.03621. Which protein is encoded by this gene? | Zinc finger protein 670 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02364","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that participates in RNA Polymerase II Transcription. Evidence for this gene in ... | |
medium_hidden_intermediate_02365 | Two genes are linked to Vaccinia virus via upregulation and to neuroblastoma as biomarkers. One of these genes exhibits a log2 fold change of 1.071 and an adjusted p-value of 0.001647 in cervical adenocarcinoma cell lines (study GSE11238). Which protein is encoded by this specific gene? | Very-long-chain enoyl-CoA reductase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02365","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Vaccinia virus via upregulation and to neuroblastoma as biomarkers. One of these genes exhibits a lo... | |
medium_hidden_intermediate_02366 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the downregulation of a specific gene, which subsequently interacts with NFIB. This gene exhibits a log2 fold change of approximately -1.73 and an adjusted p-value of 0.0489. What molecular function is enabled by this gene? | sequence-specific double-stranded DNA binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02366","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_02369 | Severe acute respiratory syndrome-related coronavirus upregulates multiple genes that are involved in the positive regulation of viral genome replication. One such gene exhibits a log2 fold change of approximately 1.01 and an adjusted p-value of 8.66e-09. Which protein is encoded by this specific gene? | Guanylate-binding protein 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02369","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates multiple genes that are involved in the positive regulatio... | |
medium_hidden_intermediate_02370 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and subsequently interacts with SFXN1. Evidence for this gene reports a log2 fold change of 1.479 and an adjusted p-value of 0.04833. Which protein is encoded by this gene? | Mitochondrial import inner membrane translocase subunit Tim13 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02370","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and subsequent... | |
medium_hidden_intermediate_02371 | Vaccinia virus downregulates a gene that participates in lipid metabolism. In a study of cervical adenocarcinoma cells (GSE11238), this gene exhibited a log2 fold change of approximately -2.73 and an adjusted p-value of 0.0318. Which biological process is this gene involved in? | positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02371","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus downregulates a gene that participates in lipid metabolism. In a study of cervical adenocarcinoma cells (GSE1... | |
medium_hidden_intermediate_02372 | Pegivirus C is reported to downregulate a gene that participates in mitochondrial protein degradation. In a study of peripheral blood mononuclear cells (GSE131504), one such gene showed a log2 fold change of approximately -1.20 and an adjusted p-value of 0.025. Which protein is encoded by this specific gene? | 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02372","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that participates in mitochondrial protein degradation. In a study of periphe... | |
medium_hidden_intermediate_02373 | Zika virus downregulates a gene that enables sphingosine-1-phosphate phosphatase activity. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -2.604 and an adjusted p-value of 0.004134. Which gene interacts with the gene identified by these expression statistics? | PLPP3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02373","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that enables sphingosine-1-phosphate phosphatase activity. In a study of glioma stem cells (... | |
medium_hidden_intermediate_02375 | Zika virus downregulates a gene that interacts with RHOA. In glioma stem cells, one such gene exhibits a log2 fold change of -2.261 and an adjusted p-value of 0.04121. Which protein is encoded by this gene? | Protein RRP5 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02375","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with RHOA. In glioma stem cells, one such gene exhibits a log2 fold change of... | |
medium_hidden_intermediate_02376 | Zika virus downregulates a gene that interacts with BRD3. In glioma stem cells (study GSE114907), one such gene exhibits a log2 fold change of -1.209 and an adjusted p-value of 0.003558. Which protein is encoded by this gene? | DNA topoisomerase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02376","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with BRD3. In glioma stem cells (study GSE114907), one such gene exhibits a l... | |
medium_hidden_intermediate_02377 | Zika virus downregulates a gene that interacts with USP7. In glioma stem cells, one such gene exhibits a log2 fold change of approximately -2.02 and an adjusted p-value of 0.0116. Which protein is encoded by this gene? | E3 ubiquitin-protein ligase MARCHF7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02377","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with USP7. In glioma stem cells, one such gene exhibits a log2 fold change of... | |
medium_hidden_intermediate_02379 | The pontine raphe nucleus is classified as a specific type of nucleus, which is itself a type of nucleus of the brain. Evidence states: 'The pontine raphe nucleus is one of the raphe nuclei. It is located in the pontine tegmentum.' Based on this evidence, which anatomical structure is the pontine raphe nucleus a part o... | brainstem | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02379","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"The pontine raphe nucleus is classified as a specific type of nucleus, which is itself a type of nucleus of the brain. Evide... | |
medium_hidden_intermediate_02380 | Zika virus downregulates a gene that participates in autophagy. Evidence for this gene shows a log2 fold change of -1.295 and an adjusted p-value of 0.01251. In which cell type is this gene enriched? | conventional dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02380","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in autophagy. Evidence for this gene shows a log2 fold change of -1.295 an... | |
medium_hidden_intermediate_02382 | Zika virus downregulates a specific gene, which in turn binds to PPARGC1A. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.885 and an adjusted p-value of 0.02865. Which protein is encoded by this gene? | Mediator of RNA polymerase II transcription subunit 24 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02382","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn binds to PPARGC1A. Experimental data for this gene in glioma stem ce... | |
medium_hidden_intermediate_02383 | Hepacivirus C upregulates a gene that is involved in the negative regulation of DNA-templated transcription. Experimental data for this gene reports a log2 fold change of approximately 2.07 and an adjusted p-value of approximately 0.0029. Which protein is encoded by this gene? | Protein HEXIM2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02383","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in the negative regulation of DNA-templated transcription. Experimental da... | |
medium_hidden_intermediate_02385 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables protein kinase activity. Experimental data for this gene reports a log2 fold change of approximately -1.795 and an adjusted p-value of 0.04212. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02385","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables protein kinase activity. Experi... | |
medium_hidden_intermediate_02387 | In a study of bronchial epithelial cells (GSE147507), Influenza A virus infection was found to downregulate a specific gene, which is also associated with breast carcinoma. This gene exhibited a log2 fold change of -1.160 and an adjusted p-value of 4.895e-09. Which cellular component is this gene located in? | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02387","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of bronchial epithelial cells (GSE147507), Influenza A virus infection was found to downregulate a specific gene,... | |
medium_hidden_intermediate_02388 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to acute lymphoblastic leukemia via genomic alterations. One of these genes has an associated study reporting a log2 fold change of approximately 1.464 and an adjusted p-value of 0.03412. Which protein is encoded by this ... | CapZ-interacting protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02388","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to acute lymphoblastic le... | |
medium_hidden_intermediate_02389 | A gene is identified as a marker for Natural killer T (NKT) cells and is associated with obesity disorder. Evidence indicates that genetic mappings have uncovered numerous shared genes among substance use, stress response, obesity, and hemodynamic traits, specifically listing CNTN4, DLG2, FHIT, GRID2, ITPR2, NOVA1, PRK... | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02389","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is identified as a marker for Natural killer T (NKT) cells and is associated with obesity disorder. Evidence indicate... | |
medium_hidden_intermediate_02390 | Two genes are structurally linked to Human immunodeficiency virus 1 via an upregulation relationship and to GRB2 via a binding relationship. One of these genes is reported in a study (GSE125686) involving natural killer cells, with a log2 fold change of approximately 2.105 and an adjusted p-value of 0.02312. Which dise... | Chagas disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02390","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via an upregulation relationship and to GRB2 via a bindi... | |
medium_hidden_intermediate_02391 | Enterovirus A is reported to downregulate a specific gene that is located in the nucleus. In a study of rhabdomyosarcoma cells (GSE103308), this gene exhibited a log2 fold change of approximately -1.164 and an adjusted p-value of 0.001615. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02391","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is reported to downregulate a specific gene that is located in the nucleus. In a study of rhabdomyosarcoma cel... | |
medium_hidden_intermediate_02393 | Enterovirus A upregulates a gene that participates in immunoregulatory interactions between a lymphoid and a non-lymphoid cell. Evidence for one such gene reports a log2 fold change of 2.299 and an adjusted p-value of 0.00879. Which cellular component is that gene located in? | membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02393","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A upregulates a gene that participates in immunoregulatory interactions between a lymphoid and a non-lymphoid ce... | |
medium_hidden_intermediate_02394 | Two distinct drugs serve as intermediates in a two-step interaction pathway connecting Morphine to Thalidomide. One of these intermediates is associated with evidence stating that 'Interactions between the ventilatory-depressant effects of agonists from the two classes were less than additive.' Identify the disease for... | insomnia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02394","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct drugs serve as intermediates in a two-step interaction pathway connecting Morphine to Thalidomide. One of these... | |
medium_hidden_intermediate_02395 | Two distinct genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells). One of these genes exhibits a log2 fold change of 2.284 and an adjusted p-value of 0.03385 in a specific study. Which cell type is enr... | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02395","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the different... | |
medium_hidden_intermediate_02397 | In a study of Hepacivirus C infection in hepatocytes (GSE132606), a gene is upregulated by the virus and participates in sensory perception. This specific gene exhibits a log2 fold change of 1.539 and an adjusted p-value of 0.0164. Which protein is encoded by this gene? | 17-beta-hydroxysteroid dehydrogenase type 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02397","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Hepacivirus C infection in hepatocytes (GSE132606), a gene is upregulated by the virus and participates in sen... | |
medium_hidden_intermediate_02399 | Zika virus downregulates a specific gene, which in turn interacts with NRAS. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.02 and an adjusted p-value of 0.0107. What molecular function is enabled by this gene? | cadherin binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02399","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with NRAS. Experimental data for this gene in glioma stem ... | |
medium_hidden_intermediate_02400 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with CASK. One of these genes has a reported log2 fold change of 1.937 and an adjusted p-value of 0.002591. Which protein is encoded by this specific gene? | SH2 domain-containing protein 4A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02400","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with CASK. One of these gene... | |
medium_hidden_intermediate_02401 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enriched in peripheral blood mononuclear cells. Evidence for this gene reports a log2 fold change of 1.092 and an adjusted p-value of 0.002472. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02401","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enriched in peripheral blood mononuclear ... |
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