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medium_hidden_intermediate_02406 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with TMEM43. Evidence for this gene reports a log2 fold change of 1.174 and an adjusted p-value of 0.007155. In which cell type is this gene enriched? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02406","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with TMEM43. Evidence for this ... | |
medium_hidden_intermediate_02407 | A protein interacts with envoplakin (EVPL) and participates in the formation of the cornified envelope. Evidence indicates that this protein's N-terminal domain interacts with the plasma membrane, it heterodimerizes with envoplakin via its rod domain, and its C-terminus interacts with intermediate filaments. Which dise... | Glycogen storage disease, type V | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02407","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A protein interacts with envoplakin (EVPL) and participates in the formation of the cornified envelope. Evidence indicates t... | |
medium_hidden_intermediate_02409 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and known to enable protein phosphatase binding was found to have a log2 fold change of approximately 1.067 and an adjusted p-value of 0.006217. Which cellular component is this gene located in? | chromatin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02409","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and known to enable protei... | |
medium_hidden_intermediate_02410 | Human immunodeficiency virus 1 downregulates a gene that participates in the regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of approximately -1.18 and an adjust... | Serine protease 23 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02410","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in the regulation of Insulin-like Growth Factor (IGF) ... | |
medium_hidden_intermediate_02411 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and involved in Interferon Signaling was found to have a log2 fold change of 1.154 and an adjusted p-value of 2.433e-05. Which protein interacts with this specific gene? | TELO2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02411","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and involved in Interferon... | |
medium_hidden_intermediate_02412 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to melanoma as biomarkers. One of these genes exhibits a log2 fold change of 1.274 and an adjusted p-value of 0.0006224 in a specific study. Which gene interacts with the gene identified by these statistical values? | RPS3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02412","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to melanoma as biomarkers... | |
medium_hidden_intermediate_02413 | Zika virus downregulates a specific gene, which in turn enables transcription corepressor activity. Experimental data from glioma stem cells (study GSE114907) indicates that this gene has a log2 fold change of approximately -1.607 and an adjusted p-value of 0.0433. Which protein is encoded by this gene? | FLYWCH-type zinc finger-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02413","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn enables transcription corepressor activity. Experimental data from g... | |
medium_hidden_intermediate_02414 | In a study of glioma stem cells (GSE114907), Zika virus infection was found to downregulate a specific gene that participates in RNA Polymerase III Chain Elongation. This gene exhibited a log2 fold change of approximately -3.70 and an adjusted p-value of approximately 0.004. Which protein is encoded by this downregulat... | DNA-directed RNA polymerase III subunit RPC9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02414","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), Zika virus infection was found to downregulate a specific gene that participate... | |
medium_hidden_intermediate_02415 | In a study of natural killer cells (GSE125686), Human immunodeficiency virus 1 upregulates a specific gene that subsequently interacts with YWHAG. This gene exhibits a log2 fold change of approximately 1.60 and an adjusted p-value of 0.01575. Which biological process is this gene involved in? | regulation of RNA splicing | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02415","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of natural killer cells (GSE125686), Human immunodeficiency virus 1 upregulates a specific gene that subsequently... | |
medium_hidden_intermediate_02416 | Pegivirus C is reported to downregulate a specific gene, the product of which is located in a protein-containing complex. In a study of peripheral blood mononuclear cells (GSE131504), this gene exhibited a log2 fold change of approximately -1.271 and an adjusted p-value of 0.04764. Which disease is associated with this... | mitochondrial complex IV deficiency, nuclear type 23 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02416","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, the product of which is located in a protein-containing complex. In... | |
medium_hidden_intermediate_02419 | Cardiovirus A downregulates a specific gene, which in turn interacts with TCEB2. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of approximately -2.36 and an adjusted p-value of approximately 0.022. Which cellular component is this gene located in? | Cul5-RING ubiquitin ligase complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02419","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A downregulates a specific gene, which in turn interacts with TCEB2. Experimental data for this gene in a cervic... | |
medium_hidden_intermediate_02420 | Vaccinia virus downregulates a gene that participates in SLC-mediated transmembrane transport. Evidence for this gene in a specific study reports a log2 fold change of -1.132 and an adjusted p-value of 0.003089. Which cell type is this gene enriched in? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02420","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus downregulates a gene that participates in SLC-mediated transmembrane transport. Evidence for this gene in a s... | |
medium_hidden_intermediate_02422 | Human alphaherpesvirus 1 upregulates a specific gene that participates in infectious disease. Evidence for this gene reports a log2 fold change of 2.215 and an adjusted p-value of 0.007773. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02422","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a specific gene that participates in infectious disease. Evidence for this gene reports... | |
medium_hidden_intermediate_02423 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and both enable phosphatidylserine binding. One of these genes exhibits a log2 fold change of -1.052 and an adjusted p-value of 1.988e-06 in a specific study. Which biological process is this specific gene involved in? | plasma membrane tubulation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02423","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and both enable phosphatidylserine bind... | |
medium_hidden_intermediate_02424 | Human alphaherpesvirus 1 upregulates a gene that interacts with HIST1H3A. In a study of monocytic leukemia cell lines (GSE114966), one such gene exhibits a log2 fold change of 2.083 and an adjusted p-value of 0.008363. Which protein is encoded by this specific gene? | Rac GTPase-activating protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02424","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that interacts with HIST1H3A. In a study of monocytic leukemia cell lines (GSE11... | |
medium_hidden_intermediate_02425 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with CKAP4. One of these genes exhibits a log2 fold change of 1.142 and an adjusted p-value of 0.0002494 in a specific study. Which protein is encoded by this gene? | 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02425","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with CKAP4. One of these gen... | |
medium_hidden_intermediate_02426 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene downregulated by Vaccinia virus and involved in Toll-like Receptor Cascades exhibited a log2 fold change of -2.138 and an adjusted p-value of 0.0002211. Which protein does this specific gene bind to? | VPS45 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02426","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene downregulated by Vaccinia virus and involved in Toll-lik... | |
medium_hidden_intermediate_02433 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and both enable calcium ion binding. One of these genes exhibits a log2 fold change of approximately -1.97 and an adjusted p-value of approximately 5.65e-05 in choroid plexus epithelium. Which disease is associated with this specific g... | prostate cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02433","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and both enable calcium ion binding. On... | |
medium_hidden_intermediate_02434 | In a study of Hepacivirus C infection in hepatocytes (GSE132606), a specific gene is downregulated and serves as a biomarker for schizophrenia. This gene exhibits a log2 fold change of -1.489 and an adjusted p-value of 0.04212. Which protein is encoded by this gene? | Synaptotagmin-11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02434","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Hepacivirus C infection in hepatocytes (GSE132606), a specific gene is downregulated and serves as a biomarker... | |
medium_hidden_intermediate_02435 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in MHC class II antigen presentation. Experimental data for this gene reports a log2 fold change of 1.067 and an adjusted p-value of 0.04857. Which disease is associated with this gene? | brain small vessel disease 6 with leukoencephalopathy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02435","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in MHC class II antigen pres... | |
medium_hidden_intermediate_02436 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes that participate in immune system processes. One such gene exhibits a log2 fold change of -2.305 and an adjusted p-value of 0.001036. Which protein is encoded by this specific gene? | Kinesin-like protein KIF20A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02436","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes that ... | |
medium_hidden_intermediate_02438 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the regulation of the apoptotic process. Experimental evidence for this gene shows a log2 fold change of 3.844 and an adjusted p-value of 0.03405. Which disease is associated with this gene as a biomarker? | adult glioblastoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02438","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the regulation of the apop... | |
medium_hidden_intermediate_02439 | Aprepitant and Elagolix are both known to interact with a specific intermediate drug. Evidence suggests that the combination of aprepitant and this intermediate drug is expected to exert synergistic inhibition of growth-enhancing signaling in glioblastoma. Which disease is this intermediate drug indicated for? | HIV infectious disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02439","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Aprepitant and Elagolix are both known to interact with a specific intermediate drug. Evidence suggests that the combination... | |
medium_hidden_intermediate_02441 | Two genes are linked to Measles morbillivirus via an upregulation relationship and to cholangiocarcinoma via an association relationship. One of these genes has a reported log2 fold change of 2.602 and an adjusted p-value of 0.04408. Which protein is encoded by this specific gene? | Interleukin-32 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02441","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Measles morbillivirus via an upregulation relationship and to cholangiocarcinoma via an association ... | |
medium_hidden_intermediate_02442 | A gene is downregulated by Hepacivirus C and participates in the development of exocrine pancreas cell lineages. Evidence for this gene shows a log2 fold change of -1.029 and an adjusted p-value of 0.005551. Which disease is associated with this gene through genomic alterations? | Steel syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02442","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Hepacivirus C and participates in the development of exocrine pancreas cell lineages. Evidence fo... | |
medium_hidden_intermediate_02444 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which in turn interacts with RHOB. This gene exhibits a log2 fold change of approximately -1.49 and an adjusted p-value of 0.0183. Which protein is encoded by this gene? | Protein ECT2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02444","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_02445 | NEDD4 interacts with a specific protein that enables protein binding. Evidence states: 'Here, we demonstrate that the protein through its PY motifs interacts with WW domains of the human NEDD4 protein.' Which protein is encoded by the gene corresponding to this interaction partner? | Protein TMEPAI | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02445","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"NEDD4 interacts with a specific protein that enables protein binding. Evidence states: 'Here, we demonstrate that the protei... | |
medium_hidden_intermediate_02446 | Hepacivirus C upregulates a gene that subsequently interacts with RPS6. In a study of hepatocytes (GSE132606), one such gene exhibits a log2 fold change of approximately 3.24 and an adjusted p-value of approximately 0.0035. Which protein is encoded by this specific gene? | Prostate tumor-overexpressed gene 1 protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02446","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that subsequently interacts with RPS6. In a study of hepatocytes (GSE132606), one such gene... | |
medium_hidden_intermediate_02447 | In a study of non-small cell lung adenocarcinoma (GSE147507), Human respirovirus 3 infection leads to the downregulation of certain genes that enable protein binding. One such gene exhibits a log2 fold change of -2.070 and an adjusted p-value of 0.04216. Which protein is encoded by this specific gene? | Cingulin-like protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02447","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma (GSE147507), Human respirovirus 3 infection leads to the downregulation of ... | |
medium_hidden_intermediate_02448 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and involved in the apoptotic factor-mediated response showed a log2 fold change of 2.738 and an adjusted p-value of 8.76e-10. Which cellular component is this gene located in? | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02448","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and involved in the apopto... | |
medium_hidden_intermediate_02450 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the upregulation of a specific gene, which subsequently binds to TGM1. This gene exhibits a log2 fold change of approximately 2.40 and an adjusted p-value of 0.029. Which cellular component is this gene located in? | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02450","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the upregulation of a specifi... | |
medium_hidden_intermediate_02452 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with GRB2. Evidence for one such gene reports a log2 fold change of 1.063 and an adjusted p-value of 0.025. Which protein is encoded by that gene? | Suppressor of cytokine signaling 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02452","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with GRB2. Evidence for one such gen... | |
medium_hidden_intermediate_02453 | Human immunodeficiency virus 1 upregulates a gene that is associated with cervical squamous cell carcinoma. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of 1.522 and an adjusted p-value of 1.095e-05. Which protein is encoded by this gene? | Transmembrane protein 54 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02453","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is associated with cervical squamous cell carcinoma. In a study of ma... | |
medium_hidden_intermediate_02454 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in EPHA-mediated growth cone collapse. Experimental data for this gene shows a log2 fold change of 1.574 and an adjusted p-value of 0.03188. Which protein is encoded by this gene? | Rho-associated protein kinase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02454","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in EPHA-mediated growth cone coll... | |
medium_hidden_intermediate_02456 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific gene that enables aminopeptidase activity. This gene exhibited a log2 fold change of approximately -1.28 and an adjusted p-value of 0.011. Which protein is encoded by this gene? | Bleomycin hydrolase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02456","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific g... | |
medium_hidden_intermediate_02458 | A gene is downregulated by Zika virus and associated with vitiligo. Experimental data for this gene in glioma stem cells reports a log2 fold change of approximately -2.58 and an adjusted p-value of approximately 0.011. Which cell type is this gene enriched in? | non-classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02458","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Zika virus and associated with vitiligo. Experimental data for this gene in glioma stem cells rep... | |
medium_hidden_intermediate_02459 | Human betaherpesvirus 5 is reported to downregulate a specific gene, which is in turn enriched in Mucosa-associated invariant T (MAIT) cells. In a study of foreskin fibroblast cell lines (GSE111036), this gene exhibited a log2 fold change of approximately -1.25 and an adjusted p-value of 0.0492. Which protein is encode... | Ankyrin repeat and EF-hand domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02459","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a specific gene, which is in turn enriched in Mucosa-associated invarian... | |
medium_hidden_intermediate_02461 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is downregulated by Vaccinia virus and enables endopeptidase activity. This specific gene exhibits a log2 fold change of approximately -1.76 and an adjusted p-value of approximately 0.014. Which protein is encoded by this gene? | Napsin-A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02461","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is downregulated by Vaccinia virus and enables endopepti... | |
medium_hidden_intermediate_02463 | Two genes are structurally linked to Cardiovirus A via an upregulation relationship and to infectious mononucleosis via an association relationship. One of these genes is reported in study GSE122967 (cervical adenocarcinoma cell line) with a log2 fold change of approximately 1.413 and an adjusted p-value of 0.01654. Wh... | Melanoma-derived growth regulatory protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02463","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Cardiovirus A via an upregulation relationship and to infectious mononucleosis via an a... | |
medium_hidden_intermediate_02466 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Dengue Virus Infection. Experimental data for this gene reports a log2 fold change of 1.340 and an adjusted p-value of 0.01768. Which protein is encoded by this gene? | Protein PML | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02466","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Dengue Virus Infection. E... | |
medium_hidden_intermediate_02467 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to the negative regulation of the ERK1 and ERK2 cascade via an 'involved in' relationship. One of these genes is associated with a log2 fold change of -1.557 and an adjusted p-value of 2.786... | intrahepatic cholangiocarcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02467","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_02468 | Zika virus downregulates a gene that is involved in the regulation of DNA replication. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -2.145 and an adjusted p-value of 0.00257. Which protein is encoded by this gene? | Ankyrin repeat domain-containing protein 17 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02468","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the regulation of DNA replication. Experimental data for this gene in gl... | |
medium_hidden_intermediate_02469 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the voltage-gated potassium channel complex. Evidence for this specific gene reports a log2 fold change of 1.066 and an adjusted p-value of 0.04797. Which molecular function is enabled by this gene? | potassium channel regulator activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02469","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the voltage-gated potassium chan... | |
medium_hidden_intermediate_02470 | In bronchial epithelial cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene is upregulated and its product is located in the mitochondrial outer membrane. Evidence for this gene reports a log2 fold change of 2.020 and an adjusted p-value of 0.007883. Which protein is encoded by th... | Metaxin-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02470","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In bronchial epithelial cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene is upregu... | |
medium_hidden_intermediate_02472 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to amyloid fibril formation via an involvement relationship. One of these genes is associated with a log2 fold change of 2.106 and an adjusted p-value of 4.711e-07. Which protein is encoded by the gene mat... | Cathelicidin antimicrobial peptide | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02472","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to amyloi... | |
medium_hidden_intermediate_02474 | In a study of Hepacivirus C infection, a specific gene is downregulated and subsequently interacts with MAPRE1. Experimental data for this gene in peripheral blood mononuclear cells (from study GSE119117) reports a log2 fold change of -1.599 and an adjusted p-value of 0.005697. Which protein is encoded by this gene? | Kinesin-like protein KIF18B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02474","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Hepacivirus C infection, a specific gene is downregulated and subsequently interacts with MAPRE1. Experimental... | |
medium_hidden_intermediate_02476 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the upregulation of a specific gene, which in turn encodes a protein that binds to POU2F1. One such gene exhibits a log2 fold change of 3.101 and an adjusted p-value of 7.962e-08. Which protein is encoded by this gene? | DNA-directed RNA polymerase III subunit RPC10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02476","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the upregulation of a specifi... | |
medium_hidden_intermediate_02478 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in protein import into the nucleus. Transcriptomic data for this gene in a cardiomyocyte cell line (study GSE151879) reports a log2 fold change of approximately 1.45 and an adjusted p-value of 0.0067. Which protein is encoded by t... | GPN-loop GTPase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02478","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in protein import into the nucleus... | |
medium_hidden_intermediate_02479 | Cardiovirus A downregulates a specific gene, which is located in a protein-containing complex. Evidence for this gene reports a log2 fold change of -1.138 and an adjusted p-value of 0.03785. Which cell type is this gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02479","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A downregulates a specific gene, which is located in a protein-containing complex. Evidence for this gene report... | |
medium_hidden_intermediate_02480 | Pegivirus C is reported to downregulate a gene that encodes a protein located on the cell surface. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.054 and an adjusted p-value of 0.005983. Which protein is encoded by this specific gene? | Leukosialin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02480","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that encodes a protein located on the cell surface. In a study of peripheral ... | |
medium_hidden_intermediate_02481 | Human betaherpesvirus 5 upregulates a gene that participates in Signal Transduction. In a study of foreskin fibroblast cell lines (GSE132081), this gene exhibited a log2 fold change of approximately 1.099 and an adjusted p-value of 0.0058. Which protein is encoded by this gene? | C-X-C motif chemokine 16 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02481","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that participates in Signal Transduction. In a study of foreskin fibroblast cell ... | |
medium_hidden_intermediate_02483 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene downregulated by Vaccinia virus and associated with ubiquitin protein ligase activity exhibits a log2 fold change of -1.752 and an adjusted p-value of 0.03812. Which cellular component is this gene located in? | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02483","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene downregulated by Vaccinia virus and associated with ubiq... | |
medium_hidden_intermediate_02484 | A gene is downregulated by Zika virus and serves as a biomarker for autism spectrum disorder. Evidence for this gene reports a log2 fold change of -1.042 and an adjusted p-value of 0.02529. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02484","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Zika virus and serves as a biomarker for autism spectrum disorder. Evidence for this gene reports... | |
medium_hidden_intermediate_02486 | In a study of Measles morbillivirus infection, multiple genes are upregulated and subsequently enable RNA polymerase II cis-regulatory region sequence-specific DNA binding. One such gene exhibits a log2 fold change of 1.233 and an adjusted p-value of 0.02397. Which protein is encoded by this specific gene? | Homeobox protein Hox-B7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02486","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, multiple genes are upregulated and subsequently enable RNA polymerase II cis-... | |
medium_hidden_intermediate_02487 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is located in the extracellular matrix. Evidence for one such gene reports a log2 fold change of -2.302 and an adjusted p-value of 0.002286. Which protein is encoded by that gene? | Plasma protease C1 inhibitor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02487","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is located in the extracellular matrix. Evid... | |
medium_hidden_intermediate_02488 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate certain genes that participate in the adaptive immune system. One such gene exhibited a log2 fold change of 1.787 and an adjusted p-value of 0.01169. Which protein is encoded by this specific gene? | E3 ubiquitin-protein ligase RNF144B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02488","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate certain genes that partici... | |
medium_hidden_intermediate_02489 | Zika virus downregulates a gene that participates in respiratory electron transport. In a study of glioma stem cells (GSE114907), one such gene showed a log2 fold change of -1.074 and an adjusted p-value of 0.01702. Which disease is associated with this specific gene? | parkinsonism with polyneuropathy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02489","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in respiratory electron transport. In a study of glioma stem cells (GSE114... | |
medium_hidden_intermediate_02490 | Zaire ebolavirus downregulates multiple genes that are enriched in eosinophils. One such gene exhibits a log2 fold change of -1.732 and an adjusted p-value of 3.688e-05 in retinal pigment epithelium cells. Which molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02490","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus downregulates multiple genes that are enriched in eosinophils. One such gene exhibits a log2 fold change of... | |
medium_hidden_intermediate_02491 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that interacts with NEDD4. Evidence for one such gene reports a log2 fold change of -1.176 and an adjusted p-value of 0.009513. Which protein is encoded by that gene? | Annexin A13 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02491","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that interacts with NEDD4. Evidence for one such ... | |
medium_hidden_intermediate_02492 | Vaccinia virus infection upregulates multiple genes involved in signal transduction. One such gene exhibits a log2 fold change of approximately 3.02 and an adjusted p-value of 1.15e-13 in cervical adenocarcinoma cells. In which cell type is this specific gene enriched? | non-classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02492","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus infection upregulates multiple genes involved in signal transduction. One such gene exhibits a log2 fold chan... | |
medium_hidden_intermediate_02494 | Zika virus downregulates multiple genes that participate in the biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and its transfer to a nascent protein. One such gene exhibits a log2 fold change of -1.166 and an adjusted p-value of 0.02435 in a specific study. Which cell type is enrich... | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02494","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates multiple genes that participate in the biosynthesis of the N-glycan precursor (dolichol lipid-linke... | |
medium_hidden_intermediate_02495 | Hepacivirus C upregulates a gene that subsequently interacts with CUL3. In a study of hepatocytes (GSE132606), one such gene exhibits a log2 fold change of approximately 2.26 and an adjusted p-value of 0.0142. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02495","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that subsequently interacts with CUL3. In a study of hepatocytes (GSE132606), one such gene... | |
medium_hidden_intermediate_02496 | Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to Neutrophil degranulation via a 'participates in' relationship. One of these genes is associated with experimental data showing a log2 fold change of approximately -4.19 and an adjusted p-value of approximately ... | ANKH | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02496","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to Neutrophil deg... | |
medium_hidden_intermediate_02498 | Zaire ebolavirus downregulates a gene that is involved in leukocyte chemotaxis. In a study of retinal pigment epithelium cells (GSE100839), one such gene exhibited a log2 fold change of approximately -1.606 and an adjusted p-value of 0.0195. Which protein is encoded by this specific gene? | G-protein coupled receptor 183 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02498","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus downregulates a gene that is involved in leukocyte chemotaxis. In a study of retinal pigment epithelium cel... | |
medium_hidden_intermediate_02499 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate genes involved in the positive regulation of type II interferon production. One such gene exhibited a log2 fold change of approximately 1.422 and an adjusted p-value of 0.001117. Which protein is encoded by thi... | Minor histocompatibility protein HMSD variant form | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02499","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate genes involved... | |
medium_hidden_intermediate_02500 | MIR34A is involved in a biological process that is a subclass of negative regulation of smooth muscle cell migration. Evidence indicates that miR-34a over-expression in serum-starved vascular smooth muscle cells (VSMCs) significantly inhibited VSMC proliferation and migration. Which biological process, connected to the... | vascular associated smooth muscle cell migration | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02500","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"MIR34A is involved in a biological process that is a subclass of negative regulation of smooth muscle cell migration. Eviden... | |
medium_hidden_intermediate_02502 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 downregulates a gene that participates in the RAF/MAP kinase cascade. One such gene exhibits a log2 fold change of -2.946 and an adjusted p-value of 0.01112. Which protein is encoded by this specific gene? | Proheparin-binding EGF-like growth factor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02502","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 downregulates a gene that participates in the RAF/MAP ... | |
medium_hidden_intermediate_02503 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and enriched in regulatory T cells exhibits a log2 fold change of 1.425 and an adjusted p-value of 4.156e-06. Which cellular component is this gene located in? | exon-exon junction complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02503","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and enriched in regulatory... | |
medium_hidden_intermediate_02504 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in intracellular signal transduction. Evidence for this specific gene reports a log2 fold change of -1.693 and an adjusted p-value of 1.606e-05. Which protein is encoded by this gene? | Calcium-regulated heat-stable protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02504","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in intracellular signal transduc... | |
medium_hidden_intermediate_02505 | Zika virus downregulates a specific gene that participates in MAPK1/MAPK3 signaling. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -1.980 and an adjusted p-value of 0.00226. Which disease is associated with this gene as a biomarker? | breast cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02505","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in MAPK1/MAPK3 signaling. In a study of glioma stem cells (GSE114... | |
medium_hidden_intermediate_02506 | A gene is upregulated by Primate bocaparvovirus 1 and participates in Gene expression (Transcription). Evidence for this gene reports a log2 fold change of 1.851 and an adjusted p-value of 0.02831. Which disease is connected to that gene through the relation 'biomarker'? | pediatric lymphoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02506","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and participates in Gene expression (Transcription). Evidence for this gen... | |
medium_hidden_intermediate_02507 | In a study of peripheral blood mononuclear cells (GSE131504), a gene is identified that is downregulated by Pegivirus C and participates in Peptide ligand-binding receptors. This specific gene exhibits a log2 fold change of -2.714 and an adjusted p-value of 0.0008756. Which protein is encoded by this gene? | Relaxin-3 receptor 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02507","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of peripheral blood mononuclear cells (GSE131504), a gene is identified that is downregulated by Pegivirus C and ... | |
medium_hidden_intermediate_02509 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is enriched in Memory CD4+ T cells. Evidence for this gene reports a log2 fold change of 3.839 and an adjusted p-value of 0.004356. Which disease is connected to this gene through genomic alterations? | combined immunodeficiency due to OX40 deficiency | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02509","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is enriched in Memory CD4+ T cells. Evide... | |
medium_hidden_intermediate_02512 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Phospholipid metabolism. Evidence for this gene reports a log2 fold change of -1.225 and an adjusted p-value of 0.008277. Which disease is connected to this gene through genomic alterations? | lipodystrophy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02512","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Phospholipid metabolism... | |
medium_hidden_intermediate_02515 | Human immunodeficiency virus 1 upregulates a gene that is enriched in Mucosa-associated invariant T (MAIT) cells. Evidence for this gene reports a log2 fold change of 1.655 and an adjusted p-value of 0.003058. Which protein is encoded by this gene? | Activating transcription factor 7-interacting protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02515","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is enriched in Mucosa-associated invariant T (MAIT) cells. Evidence f... | |
medium_hidden_intermediate_02516 | Human alphaherpesvirus 1 upregulates a gene that is located in the membrane. In a study of monocytic leukemia cell lines (GSE114966), one such gene showed a log2 fold change of 3.959 and an adjusted p-value of 0.006164. Which protein is encoded by this gene? | Condensin complex subunit 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02516","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that is located in the membrane. In a study of monocytic leukemia cell lines (GS... | |
medium_hidden_intermediate_02517 | A gene is upregulated by Primate bocaparvovirus 1 and associated with gastric adenocarcinoma. Experimental data for this gene in a non-Hodgkin lymphoma cell line (study GSE119608) reports a log2 fold change of 1.024 and an adjusted p-value of 0.03562. Which gene interacts with this specific gene? | TP53 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02517","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and associated with gastric adenocarcinoma. Experimental data for this gen... | |
medium_hidden_intermediate_02518 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that participates in the interconversion of nucleotide di- and triphosphates. One such gene exhibited a log2 fold change of -1.391 and an adjusted p-value of 0.01659. Which protein is encoded by this specific gene? | Thymidylate synthase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02518","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that participates in ... | |
medium_hidden_intermediate_02521 | Two genes are upregulated by Vaccinia virus and participate in the process 'TP53 Regulates Metabolic Genes'. One of these genes shows a log2 fold change of approximately 1.394 and an adjusted p-value of 2.395e-08 in cervical adenocarcinoma cell lines (study GSE11238). Which disease is associated with this specific gene... | Charcot-Marie-Tooth disease recessive intermediate D | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02521","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and participate in the process 'TP53 Regulates Metabolic Genes'. One of these ge... | |
medium_hidden_intermediate_02522 | In a study of peripheral blood mononuclear cells (GSE131504), Pegivirus C infection was found to downregulate genes encoding proteins with oxidoreductase activity acting on NAD(P)H with a heme protein as acceptor. One such gene exhibited a log2 fold change of -1.127 and an adjusted p-value of 0.004602. Which protein is... | Cytochrome b5 reductase 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02522","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of peripheral blood mononuclear cells (GSE131504), Pegivirus C infection was found to downregulate genes encoding... | |
medium_hidden_intermediate_02523 | Human betaherpesvirus 5 upregulates a gene that is involved in the apoptotic process. In a study of retinal pigment epithelium cells (GSE120891), one such gene showed a log2 fold change of approximately 1.855 and an adjusted p-value of 0.000165. Which protein is encoded by this specific gene? | Cysteine/serine-rich nuclear protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02523","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that is involved in the apoptotic process. In a study of retinal pigment epitheli... | |
medium_hidden_intermediate_02525 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with lung carcinoma. One of these genes has a reported log2 fold change of 1.149 and an adjusted p-value of 0.02793. Which protein is encoded by this specific gene? | Kallikrein-10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02525","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with lung carcinoma. O... | |
medium_hidden_intermediate_02526 | Enterovirus A is reported to downregulate a specific gene, which in turn participates in disease processes. Transcriptomic data from study GSE103308 indicates that this gene has a log2 fold change of -1.986 and an adjusted p-value of 0.0001357 in rhabdomyosarcoma cells. Which cell type is this gene enriched in? | non-classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02526","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is reported to downregulate a specific gene, which in turn participates in disease processes. Transcriptomic d... | |
medium_hidden_intermediate_02528 | A gene is downregulated by Human gammaherpesvirus 8 and enriched in memory B cells. Evidence for this gene reports a log2 fold change of -1.442 and an adjusted p-value of 0.009051. Which protein is encoded by this gene? | Chloride intracellular channel protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02528","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Human gammaherpesvirus 8 and enriched in memory B cells. Evidence for this gene reports a log2 fo... | |
medium_hidden_intermediate_02529 | Pegivirus C is reported to downregulate a specific gene, which in turn interacts with VPS29. In a study of peripheral blood mononuclear cells (GSE131504), this intermediate gene exhibited a log2 fold change of approximately -1.122 and an adjusted p-value of 0.02043. Which protein is encoded by this intermediate gene? | COMM domain-containing protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02529","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn interacts with VPS29. In a study of peripheral blood ... | |
medium_hidden_intermediate_02530 | Two genes are structurally linked from Pegivirus C to breast carcinoma via a downregulation relationship followed by a biomarker association. One of these genes is reported in study GSE131504 (VExD dataset, peripheral blood mononuclear cells) with a log2 fold change of approximately -1.260 and an adjusted p-value of 0.... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02530","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Pegivirus C to breast carcinoma via a downregulation relationship followed by a bioma... | |
medium_hidden_intermediate_02531 | FBXW11 interacts with a specific protein that enables protein binding. Evidence indicates that PRL promotes the interaction between this protein and the F-box protein beta-TrCP2, which serves as a substrate recognition subunit of the SCF(beta-TrCP) E3 ubiquitin ligase. Which cellular component is this protein located i... | cell surface | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02531","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"FBXW11 interacts with a specific protein that enables protein binding. Evidence indicates that PRL promotes the interaction ... | |
medium_hidden_intermediate_02532 | Human betaherpesvirus 5 downregulates a specific gene that participates in the process 'PPARA activates gene expression'. Experimental data for this gene in foreskin fibroblast cell lines (study GSE132081) reports a log2 fold change of approximately -2.66 and an adjusted p-value of approximately 0.02. Which protein int... | SMARCA4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02532","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 downregulates a specific gene that participates in the process 'PPARA activates gene expression'. Ex... | |
medium_hidden_intermediate_02533 | Hepacivirus C is reported to upregulate a gene that is involved in the defense response to fungus. Experimental data for one such gene indicates a log2 fold change of 1.943 and an adjusted p-value of 0.01658. Which protein is encoded by this specific gene? | Protein S100-A12 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02533","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to upregulate a gene that is involved in the defense response to fungus. Experimental data for one... | |
medium_hidden_intermediate_02534 | Two genes are structurally linked from Severe acute respiratory syndrome-related coronavirus via a downregulation relationship and to polyarticular arthritis via an association relationship. One of these genes is reported in a study (GSE150819) involving bronchial epithelial cells, with a log2 fold change of approximat... | Protein LBH | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02534","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Severe acute respiratory syndrome-related coronavirus via a downregulation relationsh... | |
medium_hidden_intermediate_02535 | In a study of Severe acute respiratory syndrome-related coronavirus infection in sclera cells (GSE164073), a specific gene is upregulated by the virus and interacts with LIN7B. This gene exhibits a log2 fold change of approximately 1.47 and an adjusted p-value of approximately 0.047. Which protein is encoded by this ge... | MAGUK p55 subfamily member 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02535","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection in sclera cells (GSE164073), a specific gene i... | |
medium_hidden_intermediate_02536 | A gene is downregulated by Primate bocaparvovirus 1 and is enriched in basophils. Experimental evidence for this gene reports a log2 fold change of approximately -1.26 and an adjusted p-value of 0.0238. Which disease is associated with this gene? | diabetes, deafness, developmental delay, and short stature syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02536","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and is enriched in basophils. Experimental evidence for this gene report... | |
medium_hidden_intermediate_02537 | Zika virus downregulates a specific gene, which in turn interacts with CANX. Transcriptomic data from glioma stem cells (study GSE114907) indicates that this gene has a log2 fold change of approximately -2.025 and an adjusted p-value of 0.02783. Which disease is associated with this gene? | mucopolysaccharidosis, type 10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02537","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with CANX. Transcriptomic data from glioma stem cells (stu... | |
medium_hidden_intermediate_02538 | Zika virus downregulates a specific gene that enables protein heterodimerization activity. Transcriptomic data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -1.729 and an adjusted p-value of 0.04747. Which cell type is this gene enriched in? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02538","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that enables protein heterodimerization activity. Transcriptomic data for this gene... | |
medium_hidden_intermediate_02539 | Human immunodeficiency virus 1 upregulates a gene that is involved in the positive regulation of inflammatory response. Evidence for this gene in macrophages (study GSE108897) reports a log2 fold change of approximately 1.67 and an adjusted p-value of 0.0038. Which cellular component is this gene located in? | extracellular matrix | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02539","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is involved in the positive regulation of inflammatory response. Evid... | |
medium_hidden_intermediate_02542 | Two genes are structurally linked to Human betaherpesvirus 5 via a 'downregulates' relationship and to the process 'Regulation of lipid metabolism by PPARalpha' via a 'participates in' relationship. One of these genes was reported in a study (GSE111036) on foreskin fibroblast cell lines with a log2 fold change of appro... | long-chain fatty acid-CoA ligase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02542","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human betaherpesvirus 5 via a 'downregulates' relationship and to the process 'Regulati... | |
medium_hidden_intermediate_02543 | Two genes are structurally linked to Enterovirus A via a 'downregulates' relationship and to Naive B cells via an 'enriched in' relationship. One of these genes is associated with experimental data showing a log2 fold change of approximately -2.167 and an adjusted p-value of 0.009576. Which gene is connected to this sp... | PARVA | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02543","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Enterovirus A via a 'downregulates' relationship and to Naive B cells via an 'enriched ... | |
medium_hidden_intermediate_02545 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Nucleotide salvage. Experimental data for this gene in lung cells (study GSE148697) show a log2 fold change of -2.832 and an adjusted p-value of 0.0002383. Which disease is associated with this gene through genomic alte... | malignant pancreatic neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02545","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Nucleotide salvage. Exp... | |
medium_hidden_intermediate_02546 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes involved in the transport of small molecules. One such gene exhibits a log2 fold change of -1.270 and an adjusted p-value of 0.01463. Which protein is encoded by this specific gene? | Ferritin heavy chain | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02546","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes invol... | |
medium_hidden_intermediate_02548 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in cell differentiation. Evidence for this gene reports a log2 fold change of 2.506 and an adjusted p-value of 0.03473. Which protein is encoded by this gene? | Chloride intracellular channel protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02548","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in cell differentiation. Evidence ... |
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