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medium_hidden_intermediate_02551 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in SARS-CoV Infections. Transcriptomic data for this gene reports a log2 fold change of 1.141 and an adjusted p-value of 0.03166. Which molecular function is enabled by this gene? | intracellularly calcium-gated chloride channel activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02551","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in SARS-CoV Infections. Tran... | |
medium_hidden_intermediate_02554 | Hepacivirus C upregulates a specific gene that participates in DNA Replication Pre-Initiation. Evidence for this gene reports a log2 fold change of 1.949 and an adjusted p-value of 2.123e-10. Which disease is connected to this gene through genomic alterations? | lymphoma, non-Hodgkin, familial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02554","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a specific gene that participates in DNA Replication Pre-Initiation. Evidence for this gene report... | |
medium_hidden_intermediate_02556 | In a study of Influenza A virus infection, a specific gene is upregulated by the virus and enables identical protein binding. Evidence for this gene reports a log2 fold change of 1.175 and an adjusted p-value of 1.646e-10. Which gene interacts with the entity identified by these statistical values? | TP53 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02556","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is upregulated by the virus and enables identical protein binding... | |
medium_hidden_intermediate_02557 | Rhinovirus A infection leads to the upregulation of specific genes that participate in developmental biology processes. In a study of cytotoxic T-lymphocytes (GSE106475), one such upregulated gene exhibited a log2 fold change of 1.606 and an adjusted p-value of 0.006494. Which protein is encoded by this specific gene? | Nuclear receptor subfamily 6 group A member 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02557","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection leads to the upregulation of specific genes that participate in developmental biology processes. In a... | |
medium_hidden_intermediate_02559 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the tRNA methyltransferase complex. Evidence for one such gene reports a log2 fold change of 1.236 and an adjusted p-value of 0.009975. Which protein is encoded by that gene? | tRNA (guanine(6)-N(2))-methyltransferase THUMP3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02559","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the tRNA methyltransferase compl... | |
medium_hidden_intermediate_02560 | In a study of peripheral blood mononuclear cells (GSE131504), a gene is identified as being downregulated by Pegivirus C and is associated with metal ion binding. This specific gene exhibits a log2 fold change of -2.156 and an adjusted p-value of 0.003161. Which protein is encoded by this gene? | Ribulose-phosphate 3-epimerase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02560","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of peripheral blood mononuclear cells (GSE131504), a gene is identified as being downregulated by Pegivirus C and... | |
medium_hidden_intermediate_02562 | PSMA7 is involved in multiple biological processes that are subtypes of T-helper cell differentiation. One such process is defined as the process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 17 (Th17) cell, characterized by the RORgamma-t-positive phenotype and production o... | T-helper 17 type immune response | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02562","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"PSMA7 is involved in multiple biological processes that are subtypes of T-helper cell differentiation. One such process is d... | |
medium_hidden_intermediate_02563 | SEPT10 interacts with a specific protein that enables protein binding. Evidence indicates that this protein, along with two others, can undergo homotypic or heterotypic assembly. Which cell type is this protein enriched in? | CD8-positive, alpha-beta memory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02563","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"SEPT10 interacts with a specific protein that enables protein binding. Evidence indicates that this protein, along with two ... | |
medium_hidden_intermediate_02564 | In a study of non-small cell lung adenocarcinoma, a gene downregulated by Influenza A virus and enriched in eosinophils showed a log2 fold change of approximately -1.03 and an adjusted p-value of 0.012. Which biological process is this gene involved in? | collagen biosynthetic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02564","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma, a gene downregulated by Influenza A virus and enriched in eosinophils show... | |
medium_hidden_intermediate_02565 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and associated with leukemia showed a log2 fold change of 2.589 and an adjusted p-value of 2.32e-13. Which protein is encoded by this gene? | Oligosaccharyltransferase complex subunit OSTC | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02565","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and associated with leukem... | |
medium_hidden_intermediate_02567 | Zaire ebolavirus infection leads to the downregulation of specific genes that are enriched in classical monocytes. One such gene exhibits a log2 fold change of -1.801 and an adjusted p-value of 2.288e-05 in retinal pigment epithelium cells (study GSE100839). Which protein is encoded by this gene? | Sialic acid-binding Ig-like lectin 9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02567","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus infection leads to the downregulation of specific genes that are enriched in classical monocytes. One such ... | |
medium_hidden_intermediate_02568 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, which in turn interacts with KRAS. This gene exhibited a log2 fold change of approximately 5.18 and an adjusted p-value of 1.83e-06. Which protein is encoded by this upregulated gene? | Equilibrative nucleoside transporter 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02568","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_02569 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the cellular response to insulin stimulus. One of these genes exhibits a log2 fold change of 1.626 and an adjusted p-value of 0.03641 in a specific study. Which molecular function is enabled by this specific gene? | pyrimidine nucleotide transmembrane transporter activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02569","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the cellular response... | |
medium_hidden_intermediate_02570 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by the virus and its protein product interacts with YWHAB. This gene exhibits a log2 fold change of approximately 2.50 and an adjusted p-value of approximately 4.21e-13. Which protein is encoded by thi... | C-myc promoter-binding protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02570","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by th... | |
medium_hidden_intermediate_02571 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Protein-protein interactions at synapses. Transcriptomic data for this gene in sclera cells (study GSE164073) reports a log2 fold change of approximately -1.22 and an adjusted p-value of 0.0064. Which protein is encoded... | SLIT and NTRK-like protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02571","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Protein-protein interac... | |
medium_hidden_intermediate_02572 | A gene serves as a marker for endothelial cells and is enriched in eosinophils. Evidence for one such gene reports a mean expression of 96.02 TPM, a z-score of 1.90, and a fold enrichment of 8.59. Which disease is associated with this gene as a biomarker? | hepatocellular carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02572","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for endothelial cells and is enriched in eosinophils. Evidence for one such gene reports a mean ex... | |
medium_hidden_intermediate_02574 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in nervous system development. One of these genes was reported in a study (GSE155241) with a log2 fold change of approximately 1.246 and an adjusted p-value of 0.03861. Which disease is associated with this specific gene... | Down syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02574","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in nervous system develo... | |
medium_hidden_intermediate_02575 | Human betaherpesvirus 5 is reported to downregulate a gene that is involved in the pattern recognition receptor signaling pathway. In a specific study using foreskin fibroblast cell lines, this gene exhibited a log2 fold change of -1.859 and an adjusted p-value of 0.0346. Which protein is encoded by this gene? | Baculoviral IAP repeat-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02575","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that is involved in the pattern recognition receptor signaling pa... | |
medium_hidden_intermediate_02577 | Two genes are upregulated by Cardiovirus A and are associated with melanoma. One of these genes exhibits a log2 fold change of 3.648 and an adjusted p-value of 0.04924 in cervical adenocarcinoma cell lines. Which cellular component is the location of this specific gene? | extracellular space | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02577","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Cardiovirus A and are associated with melanoma. One of these genes exhibits a log2 fold change ... | |
medium_hidden_intermediate_02578 | In a study of bronchial epithelial cells infected with Influenza A virus, a specific gene is downregulated and involved in the 3'-phosphoadenosine 5'-phosphosulfate metabolic process. Evidence for this gene reports a log2 fold change of -1.229 and an adjusted p-value of 8.553e-05. Which protein is encoded by this gene? | Sulfotransferase 1E1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02578","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of bronchial epithelial cells infected with Influenza A virus, a specific gene is downregulated and involved in t... | |
medium_hidden_intermediate_02579 | Two genes are downregulated by Influenza A virus and participate in epigenetic regulation by WDR5-containing histone modifying complexes. One of these genes exhibits a log2 fold change of -1.047 and an adjusted p-value of 1.489e-06 in non-small cell lung adenocarcinoma cell lines. Which disease is associated with genom... | lipodystrophy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02579","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Influenza A virus and participate in epigenetic regulation by WDR5-containing histone modifyi... | |
medium_hidden_intermediate_02581 | A protein encoded by a gene that interacts with CTNNA1 and is enriched in neutrophils is the subject of a study reporting: 'Here we report that yeast two-hybrid screening of a human fetal brain cDNA library using p100 as bait revealed specific interaction with alpha-catenin, which is known as a regulator of adherens ju... | IQ motif and SEC7 domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02581","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A protein encoded by a gene that interacts with CTNNA1 and is enriched in neutrophils is the subject of a study reporting: '... | |
medium_hidden_intermediate_02582 | Human immunodeficiency virus 1 upregulates a gene that is associated with prostate cancer. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately 2.67 and an adjusted p-value of 0.0073. Which protein is encoded by this gene? | FERM domain-containing protein 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02582","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is associated with prostate cancer. In a study of macrophages (GSE108... | |
medium_hidden_intermediate_02584 | Two genes are structurally linked to Cardiovirus A via a 'downregulates' relationship and to the 'Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors' via a 'participates in' relationship. One of these genes has an associated experimental record showing a log2 fold change of -1.927 and an adj... | positive regulation of DNA-templated transcription | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02584","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Cardiovirus A via a 'downregulates' relationship and to the 'Transcriptional regulation... | |
medium_hidden_intermediate_02585 | Severe acute respiratory syndrome-related coronavirus is reported to downregulate a gene that participates in Potassium Channels. Evidence for one such gene indicates a log2 fold change of -2.017 and an adjusted p-value of 0.0401. Which protein is encoded by that gene? | Calcium-activated potassium channel subunit beta-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02585","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus is reported to downregulate a gene that participates in Potassium Chan... | |
medium_hidden_intermediate_02586 | A gene serves as a marker for Natural killer T (NKT) cells and is involved in the regulation of gene expression. Experimental evidence indicates that knockdown of this gene inhibits the migration of breast cancer cells in vitro and limits the expression of estrogen receptor (ER) target genes. Which gene interacts with ... | ENY2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02586","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for Natural killer T (NKT) cells and is involved in the regulation of gene expression. Experimenta... | |
medium_hidden_intermediate_02587 | Hepacivirus C downregulates a gene that participates in Signaling by Rho GTPases. In a study of peripheral blood mononuclear cells (GSE119117), one such gene exhibits a log2 fold change of approximately -1.27 and an adjusted p-value of approximately 0.027. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02587","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a gene that participates in Signaling by Rho GTPases. In a study of peripheral blood mononuclear... | |
medium_hidden_intermediate_02588 | A genetic variant, NM_015600.4(ABHD12):c.-6898_191+7002delinsCC, is associated with a gene product that is localized to the endosome. Evidence indicates that double-labeling studies demonstrated the localization of this specific entity to transferrin receptor-positive endosomes. Which protein is encoded by this entity? | Anion exchange transporter | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02588","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A genetic variant, NM_015600.4(ABHD12):c.-6898_191+7002delinsCC, is associated with a gene product that is localized to the ... | |
medium_hidden_intermediate_02589 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and enables GDP binding. Evidence for this gene reports a log2 fold change of 1.427 and an adjusted p-value of 0.03835. Which protein is encoded by this gene? | Ras and EF-hand domain-containing protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02589","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and enables GD... | |
medium_hidden_intermediate_02590 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the detoxification of reactive oxygen species. Experimental data for this gene reports a log2 fold change of 4.583 and an adjusted p-value of 0.0329. Which protein is encoded by this gene? | Glutathione peroxidase 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02590","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the detoxification of reactive... | |
medium_hidden_intermediate_02591 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with NTRK1. One of these genes exhibits a log2 fold change of -1.061 and an adjusted p-value of 0.0001131 in a specific study. Which biological process is the gene matching these statistical values involved in? | fatty acid alpha-oxidation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02591","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with NTRK1. One of these g... | |
medium_hidden_intermediate_02592 | Pegivirus C is reported to downregulate a gene that enables DNA-binding transcription factor activity. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -1.16 and an adjusted p-value of 0.0057. Which protein is encoded by this specific gene? | Zinc finger protein 410 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02592","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that enables DNA-binding transcription factor activity. In a study of periphe... | |
medium_hidden_intermediate_02594 | Hepacivirus C is associated with the upregulation of a specific gene, which is in turn enriched in Mucosa-associated invariant T (MAIT) cells. Experimental data for this gene reports a log2 fold change of approximately 1.004 and an adjusted p-value of 0.01478. Which protein is encoded by this gene? | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02594","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is associated with the upregulation of a specific gene, which is in turn enriched in Mucosa-associated invaria... | |
medium_hidden_intermediate_02595 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the downregulation of certain genes involved in the negative regulation of cell population proliferation. One such gene exhibits a log2 fold change of -3.124 and an adjusted p-value of 0.01421. Which protein is encoded by thi... | RNA-binding protein 38 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02595","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the downregulation of certain... | |
medium_hidden_intermediate_02596 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to stroke disorder via a 'biomarker' relationship. One of these genes is associated with a log2 fold change of -2.775 and an adjusted p-value of 0.01213 in a specific study context. Which mo... | polyamine oxidase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02596","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_02598 | Human respirovirus 3 upregulates a gene that enables protein binding. Evidence for this gene in non-small cell lung adenocarcinoma cell lines (study GSE147507) reports a log2 fold change of approximately 3.43 and an adjusted p-value of 0.0366. Which disease is associated with this gene? | retinal degeneration | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02598","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human respirovirus 3 upregulates a gene that enables protein binding. Evidence for this gene in non-small cell lung adenocar... | |
medium_hidden_intermediate_02600 | Human immunodeficiency virus 1 upregulates a gene that is involved in the regulation of cell population proliferation. Evidence for this gene reports a log2 fold change of 1.011 and an adjusted p-value of 0.001087. Which protein is encoded by this gene? | Trafficking protein particle complex subunit 14 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02600","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is involved in the regulation of cell population proliferation. Evide... | |
medium_hidden_intermediate_02602 | In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and participates in Vesicle-mediated transport. This gene exhibits a log2 fold change of approximately 2.35 and an adjusted p-value of approximately 0.0009. Which protein is encoded by this gene? | Tumor protein D53 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02602","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and participates in Vesicle-m... | |
medium_hidden_intermediate_02604 | Zika virus downregulates a gene that participates in O-linked glycosylation. Evidence for this gene reports a log2 fold change of -1.213 and an adjusted p-value of 0.0203. Which cell type is this gene enriched in? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02604","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in O-linked glycosylation. Evidence for this gene reports a log2 fold chan... | |
medium_hidden_intermediate_02605 | Human betaherpesvirus 5 is linked to Plasmacytoid dendritic cells (pDCs) via an intermediate gene that is upregulated by the virus and enriched in these cells. One such intermediate gene exhibits a log2 fold change of 2.391 and an adjusted p-value of 0.03246 in a specific study. Which protein is encoded by this interme... | Heparan sulfate glucosamine 3-O-sulfotransferase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02605","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is linked to Plasmacytoid dendritic cells (pDCs) via an intermediate gene that is upregulated by the... | |
medium_hidden_intermediate_02606 | Human immunodeficiency virus 1 downregulates a gene that participates in the S Phase. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of -2.836 and an adjusted p-value of 0.0006665. Which protein is encoded by this gene? | Transcription factor E2F1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02606","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in the S Phase. In a study of macrophages (GSE108897),... | |
medium_hidden_intermediate_02608 | A protein interacts with GNAQ and is involved in protein binding. Experimental evidence indicates that immunoprecipitation of the full-length protein or pull-down of a GST-fused fragment (residues 45-178) of this protein resulted in the detection of G alpha(q), but not G alpha(16), in an activation-dependent manner. Wh... | Beta-adrenergic receptor kinase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02608","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A protein interacts with GNAQ and is involved in protein binding. Experimental evidence indicates that immunoprecipitation o... | |
medium_hidden_intermediate_02609 | A gene is linked to Epithelial cell via the 'has marker' relationship and to gastric adenocarcinoma via the 'associated with' relationship. Evidence regarding one such gene states: 'Patients (209) with primary gastric adenocarcinoma were evaluated for the expression of this gene by immunohistochemistry.' Which cell typ... | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02609","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is linked to Epithelial cell via the 'has marker' relationship and to gastric adenocarcinoma via the 'associated with... | |
medium_hidden_intermediate_02610 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene located in the endoplasmic reticulum was found to be upregulated by the virus. This gene exhibited a log2 fold change of approximately 1.76 and an adjusted p-value of approximately 1.99e-08. Which protein does this g... | BAG2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02610","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene located in the endop... | |
medium_hidden_intermediate_02611 | Identify the protein encoded by the gene that interacts with HRAS and is located in the cytoplasm, given that evidence indicates this entity interacts with Ras and Raf to form a ternary complex. | Leucine-rich repeat protein SHOC-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02611","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Identify the protein encoded by the gene that interacts with HRAS and is located in the cytoplasm, given that evidence indic... | |
medium_hidden_intermediate_02613 | Zika virus downregulates a gene that participates in peptide hormone metabolism. In glioma stem cells, this gene exhibits a log2 fold change of -1.769 and an adjusted p-value of 0.01609. Which protein is encoded by this gene? | Exocyst complex component 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02613","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in peptide hormone metabolism. In glioma stem cells, this gene exhibits a ... | |
medium_hidden_intermediate_02616 | Severe acute respiratory syndrome-related coronavirus downregulates a specific gene, the product of which is located in a protein-containing complex. Transcriptomic data for this gene in choroid plexus epithelium shows a log2 fold change of -1.417 and an adjusted p-value of 9.456e-05. Which molecular function is enable... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02616","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a specific gene, the product of which is located in a pr... | |
medium_hidden_intermediate_02617 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the transport of vitamins, nucleosides, and related molecules. One of these genes exhibits a log2 fold change of approximately 1.119 and an adjusted p-value of 0.03711 in a specific study. What molecular function is en... | 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02617","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the transport of vitam... | |
medium_hidden_intermediate_02619 | Two genes are downregulated by Pegivirus C and are both associated with adenoviridae infectious disease. One of these genes exhibits a log2 fold change of -1.809 and an adjusted p-value of 0.001036 in peripheral blood mononuclear cells (study GSE131504). Which disease is genetically associated with this specific gene? | cervical cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02619","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and are both associated with adenoviridae infectious disease. One of these genes ... | |
medium_hidden_intermediate_02623 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 downregulates a gene that subsequently interacts with RHOB. One such gene exhibits a log2 fold change of -1.457 and an adjusted p-value of 3.173e-05. Which protein is encoded by this specific gene? | SH3 domain-binding protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02623","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 downregulates a gene that subsequently interacts with ... | |
medium_hidden_intermediate_02625 | In a study of umbilical vein endothelial cells (GSE119608), a gene is identified as being downregulated by Human gammaherpesvirus 8 and is associated with alpha-tubulin binding. This specific gene exhibits a log2 fold change of approximately -1.196 and an adjusted p-value of 0.007457. Which protein is encoded by this g... | Trafficking protein particle complex subunit 14 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02625","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of umbilical vein endothelial cells (GSE119608), a gene is identified as being downregulated by Human gammaherpes... | |
medium_hidden_intermediate_02626 | In a study of Rift Valley fever phlebovirus infection in SAEC cells (GSE102481), a specific gene is upregulated by the virus and its expression is enriched in natural killer cells. Evidence for this gene reports a log2 fold change of 1.527 and an adjusted p-value of 0.0009826. Which protein is encoded by this gene? | Bone marrow stromal antigen 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02626","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Rift Valley fever phlebovirus infection in SAEC cells (GSE102481), a specific gene is upregulated by the virus... | |
medium_hidden_intermediate_02628 | Two genes are structurally linked to Influenza A virus via a downregulation relationship and to conventional dendritic cells via an enrichment relationship. One of these genes exhibits a log2 fold change of approximately -1.009 and an adjusted p-value of 1.811e-10 in the specified context. Which disease is associated w... | neurodevelopmental disorder with early-onset parkinsonism and behavioral abnormalities | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02628","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Influenza A virus via a downregulation relationship and to conventional dendritic cells... | |
medium_hidden_intermediate_02629 | Vaccinia virus upregulates a gene that is involved in the positive regulation of angiogenesis. Evidence for this gene reports a log2 fold change of 2.264 and an adjusted p-value of 2.749e-07. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02629","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a gene that is involved in the positive regulation of angiogenesis. Evidence for this gene report... | |
medium_hidden_intermediate_02631 | Zika virus downregulates a gene that interacts with ANLN. Experimental data for this gene in glioma stem cells (study GSE114907) shows a log2 fold change of -1.343 and an adjusted p-value of 0.02319. Which protein is encoded by this gene? | Septin-10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02631","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with ANLN. Experimental data for this gene in glioma stem cells (study GSE114... | |
medium_hidden_intermediate_02632 | A gene is downregulated by Zika virus and serves as a biomarker for breast cancer. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -1.178 and an adjusted p-value of 0.01355. Which cellular component is this gene located in? | cytosol | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02632","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Zika virus and serves as a biomarker for breast cancer. Experimental data for this gene in glioma... | |
medium_hidden_intermediate_02634 | Vaginal Neoplasms are localized to an anatomical structure that is a mesoderm-derived structure. One such structure is described as a fibromuscular tubular tract leading from the uterus to the exterior of the body in female placental mammals and marsupials, or to the cloaca in female birds, monotremes, and some reptile... | internal female genitalia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02634","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaginal Neoplasms are localized to an anatomical structure that is a mesoderm-derived structure. One such structure is descr... | |
medium_hidden_intermediate_02635 | In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and participates in chromatin modifying enzyme activity. Evidence for this gene reports a log2 fold change of 1.466 and an adjusted p-value of 0.00145. Which protein is encoded by this gene? | ZZ-type zinc finger-containing protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02635","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and participates in chromatin mod... | |
medium_hidden_intermediate_02636 | In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and participates in Neutrophil degranulation. This specific gene exhibits a log2 fold change of 1.115 and an adjusted p-value of 0.000292. Which protein is encoded by this gene? | Protein yippee-like 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02636","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and participates in Neutrophi... | |
medium_hidden_intermediate_02637 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in the Cell Cycle. Experimental data for this gene in the VExD dataset (study GSE157852) reports a log2 fold change of approximately -1.35 and an adjusted p-value of approximately 0.0039. In which cell type is this gene en... | gamma-delta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02637","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in the Cell Cycle. Experim... | |
medium_hidden_intermediate_02638 | Human immunodeficiency virus 1 downregulates a gene that is involved in intracellular zinc ion homeostasis. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of -4.031 and an adjusted p-value of 0.0008136. Which disease is associated with this gene? | SLC39A8-CDG | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02638","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is involved in intracellular zinc ion homeostasis. Evidence for thi... | |
medium_hidden_intermediate_02639 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in small GTPase-mediated signal transduction. Evidence for this gene reports a log2 fold change of approximately -1.082 and an adjusted p-value of approximately 0.0032. Which cell type is this gene enriched in? | non-classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02639","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in small GTPase-mediated si... | |
medium_hidden_intermediate_02640 | A gene is downregulated by Vaccinia virus and enables RNA binding. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately -2.29 and an adjusted p-value of 0.0017. Which disease is associated with this gene? | hereditary chronic pancreatitis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02640","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Vaccinia virus and enables RNA binding. Experimental data for this gene in a cervical adenocarcin... | |
medium_hidden_intermediate_02642 | In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upregulate a gene that participates in the recognition and association of DNA glycosylase with a site containing an affected pyrimidine. One such gene exhibited a log2 fold change of 1.092 and an adjus... | Endonuclease 8-like 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02642","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upreg... | |
medium_hidden_intermediate_02643 | Zika virus downregulates a specific gene, which in turn interacts with TPTE. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -1.342 and an adjusted p-value of 0.0142. Which biological process is this gene involved in? | tRNA export from nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02643","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with TPTE. Experimental data for this gene in glioma stem ... | |
medium_hidden_intermediate_02644 | Influenza A virus upregulates a gene that participates in GPCR ligand binding. Evidence for one such gene reports a log2 fold change of 1.723 and an adjusted p-value of 0.04774. Which cell type is this gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02644","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Influenza A virus upregulates a gene that participates in GPCR ligand binding. Evidence for one such gene reports a log2 fol... | |
medium_hidden_intermediate_02645 | Zika virus downregulates a gene that interacts with MATR3. In glioma stem cells, one such downregulated gene exhibits a log2 fold change of approximately -2.08 and an adjusted p-value of approximately 0.0039. Which protein is encoded by this specific gene? | Heterogeneous nuclear ribonucleoprotein U-like protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02645","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with MATR3. In glioma stem cells, one such downregulated gene exhibits a log2... | |
medium_hidden_intermediate_02646 | In a study of lung cells (GSE148697), Severe acute respiratory syndrome-related coronavirus was found to downregulate a specific gene, which serves as a biomarker for Alzheimer disease. This gene exhibited a log2 fold change of -2.667 and an adjusted p-value of 0.003981. Which protein is encoded by this gene? | Glutaminyl-peptide cyclotransferase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02646","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells (GSE148697), Severe acute respiratory syndrome-related coronavirus was found to downregulate a spec... | |
medium_hidden_intermediate_02647 | Severe acute respiratory syndrome-related coronavirus upregulates a specific gene product, which in turn participates in the regulation of CDH1 expression and function. Experimental data for this intermediate entity reports a log2 fold change of 2.721 and an adjusted p-value of 0.04948. Which protein is encoded by this... | Histone H3.1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02647","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a specific gene product, which in turn participates in the... | |
medium_hidden_intermediate_02649 | Human betaherpesvirus 5 is reported to downregulate a gene that participates in diseases of glycosylation. Evidence for one such gene indicates a log2 fold change of -1.037 and an adjusted p-value of 0.04102. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02649","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that participates in diseases of glycosylation. Evidence for one ... | |
medium_hidden_intermediate_02650 | Two genes are structurally linked to Enterovirus A via downregulation and to eosinophils via enrichment. One of these genes exhibits a log2 fold change of -1.372 and an adjusted p-value of 0.007817 in rhabdomyosarcoma cells. Which biological process is associated with this specific gene through involvement? | response to X-ray | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02650","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Enterovirus A via downregulation and to eosinophils via enrichment. One of these genes ... | |
medium_hidden_intermediate_02651 | Two genes are upregulated by Vaccinia virus and are involved in the positive regulation of type II interferon production. One of these genes exhibits a log2 fold change of approximately 1.42 and an adjusted p-value of 0.0011 in cervical adenocarcinoma cell lines. Which disease is associated with this specific gene? | leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02651","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and are involved in the positive regulation of type II interferon production. On... | |
medium_hidden_intermediate_02652 | In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and participates in FGFR1 signaling. This gene exhibits a log2 fold change of approximately 2.04 and an adjusted p-value of approximately 0.0049. Which protein is encoded by this gene? | Sprouty-related, EVH1 domain-containing protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02652","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and participates in FGFR1 signali... | |
medium_hidden_intermediate_02653 | Measles morbillivirus upregulates a gene that enables transcription corepressor activity. In study GSE131840, one such gene exhibits a log2 fold change of approximately 2.076 and an adjusted p-value of 0.00427. Which protein is encoded by this specific gene? | Cbp/p300-interacting transactivator 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02653","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that enables transcription corepressor activity. In study GSE131840, one such gene ... | |
medium_hidden_intermediate_02655 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to ADP-ribose diphosphatase activity via an enables relationship. One of these genes is associated with a log2 fold change of approximately 1.14 and an adjusted p-value of approximately 0.0002... | ADP-ribose pyrophosphatase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02655","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship ... | |
medium_hidden_intermediate_02656 | Two genes are upregulated by Human alphaherpesvirus 1 and enriched in non-classical monocytes. One of these genes exhibits a log2 fold change of 1.817 and an adjusted p-value of 0.004662 in a monocytic leukemia cell line. Which cellular component is the location of this specific gene? | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02656","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human alphaherpesvirus 1 and enriched in non-classical monocytes. One of these genes exhibits a... | |
medium_hidden_intermediate_02659 | A gene is downregulated by Cardiovirus A and participates in Hemostasis. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of -1.514 and an adjusted p-value of 0.01358. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02659","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Cardiovirus A and participates in Hemostasis. Experimental data for this gene in a cervical adeno... | |
medium_hidden_intermediate_02661 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to the process 'Synthesis of IP2, IP, and Ins in the cytosol' via a 'participates in' relationship. One of these genes is associated with experimental data showing a log2 fold change of appr... | Inositol monophosphatase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02661","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_02664 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with HIST1H2BG. One of these genes exhibits a log2 fold change of -1.537 and an adjusted p-value of 1.009e-06 in lung tissue. What molecular function is enabled by this specific gene? | RNA binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02664","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with HIST1H2BG. One of the... | |
medium_hidden_intermediate_02666 | Pegivirus C is reported to downregulate a gene that enables calcium ion binding. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.268 and an adjusted p-value of 0.008977. Which protein is encoded by this specific gene? | EF-hand calcium-binding domain-containing protein 4B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02666","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that enables calcium ion binding. In a study of peripheral blood mononuclear ... | |
medium_hidden_intermediate_02667 | Pegivirus C downregulates a gene that enables the function of a structural constituent of the cytoskeleton. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -1.04 and an adjusted p-value of 0.0237. Which protein is encoded by this gene? | Vinexin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02667","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that enables the function of a structural constituent of the cytoskeleton. In a study of pe... | |
medium_hidden_intermediate_02670 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a gene that is located in the nucleolus. One such gene exhibited a log2 fold change of 1.754 and an adjusted p-value of 0.0002756. Which protein is encoded by this specific gene? | Coiled-coil domain-containing protein 86 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02670","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a gene that is loca... | |
medium_hidden_intermediate_02676 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the downregulation of certain genes located in the lysosome. One such gene exhibits a log2 fold change of approximately -1.19 and an adjusted p-value of 0.039. Which protein is encoded by this specific gene? | Immunity-related GTPase family Q protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02676","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the downregulation of certain gene... | |
medium_hidden_intermediate_02677 | Zaire ebolavirus downregulates a gene that is enriched in neutrophils. Evidence for this gene in a retinal pigment epithelium cell line (study GSE100839) reports a log2 fold change of -1.028 and an adjusted p-value of 0.0009482. Which protein is encoded by this gene? | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02677","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus downregulates a gene that is enriched in neutrophils. Evidence for this gene in a retinal pigment epitheliu... | |
medium_hidden_intermediate_02679 | Human betaherpesvirus 5 upregulates a gene that is located in the extracellular space. Evidence for this gene reports a log2 fold change of 1.247 and an adjusted p-value of 0.01639. Which cell type is this gene enriched in? | peripheral blood mononuclear cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02679","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that is located in the extracellular space. Evidence for this gene reports a log2... | |
medium_hidden_intermediate_02683 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables kinase binding. Experimental data for this gene shows a log2 fold change of -1.022 and an adjusted p-value of 0.0003576. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02683","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables kinase binding. Experimental da... | |
medium_hidden_intermediate_02684 | NCOA2 interacts with a nuclear receptor that participates in the process where SUMO E3 ligases SUMOylate target proteins. Experimental evidence indicates that the compound ZK159222 failed to promote a ligand-dependent interaction between this specific receptor and the coactivator proteins SRC-1, TIF2, and RAC3, neither... | Vitamin D3 receptor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02684","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"NCOA2 interacts with a nuclear receptor that participates in the process where SUMO E3 ligases SUMOylate target proteins. Ex... | |
medium_hidden_intermediate_02685 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated by the virus and is involved in RNA processing. Evidence for this gene reports a log2 fold change of -1.460 and an adjusted p-value of 0.0004849. Which protein is encoded by this gene? | Ribonuclease P/MRP protein subunit POP5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02685","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated by the virus... | |
medium_hidden_intermediate_02688 | Human immunodeficiency virus 1 upregulates a gene that is located on the cell surface. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of 5.956 and an adjusted p-value of 0.01135. Which disease is associated with this gene as a biomarker? | esophageal atresia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02688","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is located on the cell surface. Evidence for this gene in macrophages... | |
medium_hidden_intermediate_02690 | Zika virus upregulates a specific gene, which is subsequently associated with a disease. Experimental data for this gene in neural stem cells (study GSE129180) reports a log2 fold change of approximately 1.27 and an adjusted p-value of 0.03676. Which disease is linked to this gene via genomic alterations? | gallbladder carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02690","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a specific gene, which is subsequently associated with a disease. Experimental data for this gene in ... | |
medium_hidden_intermediate_02692 | Two genes are upregulated by Influenza A virus and enriched in intermediate monocytes. One of these genes exhibits a log2 fold change of 1.296 and an adjusted p-value of 4.059e-11 in non-small cell lung adenocarcinoma cell lines. Which disease is associated with genomic alterations in this specific gene? | inborn error of immunity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02692","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Influenza A virus and enriched in intermediate monocytes. One of these genes exhibits a log2 fo... | |
medium_hidden_intermediate_02694 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes involved in transcription initiation-coupled chromatin remodeling. One such gene exhibited a log2 fold change of 1.630 and an adjusted p-value of 2.163e-07. Which protein is encoded by this specif... | Sphingosine kinase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02694","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes ... | |
medium_hidden_intermediate_02695 | A gene is upregulated by Human immunodeficiency virus 1 and participates in the response of endothelial cells to shear stress. Experimental data for this gene in natural killer cells shows a log2 fold change of approximately 2.536 and an adjusted p-value of 0.000552. Which protein is encoded by this gene? | Pro-adrenomedullin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02695","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human immunodeficiency virus 1 and participates in the response of endothelial cells to shear stres... | |
medium_hidden_intermediate_02696 | Hepacivirus C downregulates a gene that participates in Pre-NOTCH Expression and Processing. In a study of peripheral blood mononuclear cells (GSE119117), one such gene showed a log2 fold change of -1.123 and an adjusted p-value of 0.005513. Which protein is encoded by this specific gene? | Beta-1,3-N-acetylglucosaminyltransferase radical fringe | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02696","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a gene that participates in Pre-NOTCH Expression and Processing. In a study of peripheral blood ... | |
medium_hidden_intermediate_02697 | Two distinct genes are upregulated by Severe acute respiratory syndrome-related coronavirus and subsequently bind to SOCS1. One of these genes exhibits a log2 fold change of 9.327 and an adjusted p-value of 0.02494 in lung cells. Which disease is associated with this specific gene as a biomarker? | hepatocellular carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02697","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct genes are upregulated by Severe acute respiratory syndrome-related coronavirus and subsequently bind to SOCS1. ... | |
medium_hidden_intermediate_02698 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables protein serine/threonine kinase activity. Experimental data for this gene reports a log2 fold change of -2.754 and an adjusted p-value of 0.01842. Which cellular component is this gene located in? | microtubule organizing center | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02698","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables protein serine/threonine kinase... | |
medium_hidden_intermediate_02699 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the response to acetylcholine. Experimental evidence for this gene reports a log2 fold change of 1.765 and an adjusted p-value of 0.001669. Which protein is encoded by this gene? | Neuronal acetylcholine receptor subunit alpha-6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02699","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the response to acetylchol... | |
medium_hidden_intermediate_02701 | Two genes are downregulated by Pegivirus C and participate in Sensory Perception. One of these genes exhibits a log2 fold change of -1.473 and an adjusted p-value of 0.002813 in peripheral blood mononuclear cells (study GSE131504). Which disease is associated with genomic alterations in this specific gene? | breast carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02701","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and participate in Sensory Perception. One of these genes exhibits a log2 fold ch... | |
medium_hidden_intermediate_02702 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in the regulation of cholesterol biosynthesis by SREBP (SREBF). One of these genes exhibits a log2 fold change of approximately -1.22 and an adjusted p-value of approximately 0.0032 in lung adenocarcinoma cells. Which d... | adenoviridae infectious disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02702","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in the regulation of ch... | |
medium_hidden_intermediate_02703 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables histone H3K4me3 reader activity. Evidence for one such gene reports a log2 fold change of 1.015 and an adjusted p-value of 0.0255. Which protein is encoded by that gene? | Inhibitor of growth protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02703","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables histone H3K4me3 reader activity. Evide... |
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