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medium_hidden_intermediate_02704 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 downregulates a specific gene that participates in G alpha (s) signalling events. This gene exhibits a log2 fold change of -1.978 and an adjusted p-value of 0.002431. Which molecular function is enabled by this gene? | 3',5'-cyclic-AMP phosphodiesterase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02704","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 downregulates a specific gene that participates in G a... | |
medium_hidden_intermediate_02705 | Enterovirus A upregulates a gene that is located in the mitochondrial inner membrane. Evidence for one such gene reports a log2 fold change of 1.906 and an adjusted p-value of 0.03617. Which molecular function is enabled by that gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02705","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A upregulates a gene that is located in the mitochondrial inner membrane. Evidence for one such gene reports a l... | |
medium_hidden_intermediate_02707 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and participates in Aerobic respiration and respiratory electron transport. Evidence for this gene reports a log2 fold change of -1.388 and an adjusted p-value of 0.001464. Which gene interacts with the entit... | AASDHPPT | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02707","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and particip... | |
medium_hidden_intermediate_02709 | Two genes are structurally linked to Hepacivirus C via a 'downregulates' relationship and to the biological process 'Response to elevated platelet cytosolic Ca2+' via a 'participates in' relationship. One of these genes has an associated expression profile showing a log2 fold change of -2.358 and an adjusted p-value of... | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02709","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Hepacivirus C via a 'downregulates' relationship and to the biological process 'Respons... | |
medium_hidden_intermediate_02710 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to Diseases of glycosylation via a 'participates in' relationship. One of these genes is associated with experimental data showing a log2 fold change of -1.167 and an adjusted p-value of 1.7... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02710","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_02712 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which in turn participates in the regulation of CDH1 gene transcription. Experimental data for this gene shows a log2 fold change of approximately -1.85 and an adjusted p-value of 0.013.... | M-phase phosphoprotein 8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02712","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_02713 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in SARS-CoV-2 Infection. Evidence for this gene in choroid plexus epithelium (study GSE157852) reports a log2 fold change of -1.124 and an adjusted p-value of 0.002286. Which disease is associated with this gene? | neurodevelopmental disorder with achalasia, polyneuropathy, and alacrima | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02713","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in SARS-CoV-2 Infection. E... | |
medium_hidden_intermediate_02714 | Two genes are linked to Human immunodeficiency virus 1 via a downregulation relationship and to ulcer disease via an association. One of these genes exhibits a log2 fold change of approximately -3.20 and an adjusted p-value of 0.0239 in macrophages. Which cellular component is the location of this specific gene? | extracellular matrix | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02714","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Human immunodeficiency virus 1 via a downregulation relationship and to ulcer disease via an associa... | |
medium_hidden_intermediate_02715 | Cyclosporine and Glyburide are linked via a shared interacting partner. Evidence indicates that cyclosporine A partially inhibits CF cytotoxicity. Which disease is the indication for this shared interacting partner? | Familial type 3 hyperlipoproteinemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02715","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cyclosporine and Glyburide are linked via a shared interacting partner. Evidence indicates that cyclosporine A partially inh... | |
medium_hidden_intermediate_02716 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in turn interacts with PARK2. This gene exhibited a log2 fold change of -1.619 and an adjusted p-value of 0.01174. Which protein is encoded by this gene? | Mitochondrial adenyl nucleotide antiporter SLC25A25 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02716","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in tu... | |
medium_hidden_intermediate_02717 | Zika virus upregulates a gene that is located in the Golgi membrane. Evidence for this gene in glioblastoma multiforme cancer stem cells reports a log2 fold change of 1.156 and an adjusted p-value of 0.01658. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02717","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that is located in the Golgi membrane. Evidence for this gene in glioblastoma multiforme cance... | |
medium_hidden_intermediate_02718 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and participates in tRNA processing. This specific gene exhibits a log2 fold change of approximately 1.292 and an adjusted p-value of 8.452e-05. Which protein is encoded by this gene? | tRNA wybutosine-synthesizing protein 3 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02718","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and participates in tRN... | |
medium_hidden_intermediate_02721 | In a study of Dengue virus infection in hepatoma cells (GSE110512), a specific gene is downregulated by the virus and its product interacts with CUL3. This gene exhibits a log2 fold change of approximately -1.013 and an adjusted p-value of 0.00812. Which protein is encoded by this gene? | BTB/POZ domain-containing protein KCTD18 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02721","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Dengue virus infection in hepatoma cells (GSE110512), a specific gene is downregulated by the virus and its pr... | |
medium_hidden_intermediate_02722 | Two biological processes serve as intermediate categories between 'regulation of juvenile hormone catabolic process' and 'regulation of lipid metabolic process' via 'is a' relationships. One of these intermediate processes is defined by the evidence: 'Any process that modulates the frequency, rate or extent of the chem... | isoprenoid metabolic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02722","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two biological processes serve as intermediate categories between 'regulation of juvenile hormone catabolic process' and 're... | |
medium_hidden_intermediate_02723 | Zika virus downregulates a gene that interacts with IFI16. In glioma stem cells (study GSE114907), one such gene exhibits a log2 fold change of approximately -2.093 and an adjusted p-value of 0.009832. Which protein is encoded by this gene? | Probable ATP-dependent RNA helicase DDX10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02723","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with IFI16. In glioma stem cells (study GSE114907), one such gene exhibits a ... | |
medium_hidden_intermediate_02726 | A gene is upregulated by Measles morbillivirus and enriched in naive B cells. Evidence for this gene reports a log2 fold change of approximately 1.19 and an adjusted p-value of 0.0252. Which molecular function is enabled by this gene? | phosphatidylinositol binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02726","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and enriched in naive B cells. Evidence for this gene reports a log2 fold cha... | |
medium_hidden_intermediate_02728 | Human polyomavirus 1 upregulates a gene that is enriched in plasmacytoid dendritic cells. Evidence for this gene reports a log2 fold change of 3.867 and an adjusted p-value of 0.01543. Which cellular component is this gene located in? | axoneme | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02728","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human polyomavirus 1 upregulates a gene that is enriched in plasmacytoid dendritic cells. Evidence for this gene reports a l... | |
medium_hidden_intermediate_02730 | Zika virus downregulates a specific gene that is involved in the positive regulation of DNA repair. Transcriptomic data from glioma stem cells (study GSE114907) indicates that this gene has a log2 fold change of approximately -1.44 and an adjusted p-value of 0.013. Which disease is associated with this gene? | sarcoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02730","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is involved in the positive regulation of DNA repair. Transcriptomic data from... | |
medium_hidden_intermediate_02731 | In a study of cervical adenocarcinoma cell lines (GSE122967), a gene is downregulated by Cardiovirus A and participates in the Cell Cycle. This specific gene exhibits a log2 fold change of -1.014 and an adjusted p-value of 0.01164. Which protein does this gene bind to? | PPP2R2D | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02731","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), a gene is downregulated by Cardiovirus A and participates in t... | |
medium_hidden_intermediate_02732 | Two genes are downregulated by Human betaherpesvirus 5 and are enriched in conventional dendritic cells. One of these genes exhibits a log2 fold change of -1.125 and an adjusted p-value of 0.004503 in foreskin fibroblast cell lines. Which cellular component is the location of this specific gene? | cytosol | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02732","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Human betaherpesvirus 5 and are enriched in conventional dendritic cells. One of these genes ... | |
medium_hidden_intermediate_02734 | EP300 interacts with a protein that enables protein binding. Evidence indicates that a T507A mutant of this protein exhibits increased binding efficiency to cyclin B1. Which protein is encoded by the gene corresponding to this entity? | M-phase inducer phosphatase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02734","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"EP300 interacts with a protein that enables protein binding. Evidence indicates that a T507A mutant of this protein exhibits... | |
medium_hidden_intermediate_02735 | A gene serves as a marker for Club cells (Clara cells) and is enriched in non-classical monocytes. Evidence for this gene includes a mean expression of 43.00 TPM, a z-score of 2.10, and a fold enrichment of 9.53. Which disease is associated with this gene? | invasive carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02735","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for Club cells (Clara cells) and is enriched in non-classical monocytes. Evidence for this gene in... | |
medium_hidden_intermediate_02736 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to downregulate a specific gene that participates in post-translational protein modification. This gene exhibited a log2 fold change of approximately -1.09 and an adjusted p-value of 0.02165. Which protein is encoded by this gene... | Tubulin monoglycylase TTLL3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02736","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to downregulate a specific gene t... | |
medium_hidden_intermediate_02738 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and localized to the lysosome. This gene exhibits a log2 fold change of 1.416 and an adjusted p-value of 0.0001432. Which biological process is this gene involved in? | regulation of autophagy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02738","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and l... | |
medium_hidden_intermediate_02740 | In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), a specific gene is upregulated by Influenza A virus and associated with colitis. This gene exhibits a log2 fold change of approximately 1.28 and an adjusted p-value of 0.0002757. Which disease is this gene reported to be protective against? | bone resorption disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02740","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), a specific gene is upregulated by Influenza A virus... | |
medium_hidden_intermediate_02741 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a gene that participates in Mitotic G2-G2/M phases. One such gene exhibits a log2 fold change of 2.464 and an adjusted p-value of 4.261e-05. Which protein is encoded by this specific gene? | Treslin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02741","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a gene that participates in Mitotic ... | |
medium_hidden_intermediate_02744 | In a study of Influenza A virus infection, a specific gene is upregulated by the virus and is involved in cell-cell signaling. Experimental data for this gene reports a log2 fold change of approximately 1.248 and an adjusted p-value of 0.0469. Which protein is encoded by this gene? | Interleukin-18 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02744","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is upregulated by the virus and is involved in cell-cell signalin... | |
medium_hidden_intermediate_02745 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene, which in turn enables ATPase binding. This gene exhibited a log2 fold change of 3.017 and an adjusted p-value of 0.007916. What is the name of the protein encoded by this gene? | Small VCP/p97-interacting protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02745","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene, which in ... | |
medium_hidden_intermediate_02746 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection was found to downregulate certain genes whose products are located in the membrane. One such gene exhibited a log2 fold change of -1.240 and an adjusted p-value of 0.0001378. Which protein is encoded by this specific gene? | Synaptogyrin-3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02746","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection was found to downregulate certain gene... | |
medium_hidden_intermediate_02747 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and participates in the biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and its transfer to a nascent protein. Evidence for this gene reports a log2 fold change of -1.607 a... | classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02747","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and particip... | |
medium_hidden_intermediate_02748 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to colon carcinoma via biomarker association. One of these genes exhibits a log2 fold change of approximately 1.89 and an adjusted p-value of approximately 0.0303 in a specific study. Which cell type is enriched for this ... | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02748","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to colon carcinoma via bi... | |
medium_hidden_intermediate_02749 | Zika virus downregulates a specific gene that subsequently interacts with TRIM27. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -2.46 and an adjusted p-value of 0.0402. Which biological process is this gene involved in? | Rho protein signal transduction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02749","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that subsequently interacts with TRIM27. In a study of glioma stem cells (GSE114907... | |
medium_hidden_intermediate_02750 | In a study of glioma stem cells (GSE114907), a gene downregulated by Zika virus and known to interact with RNF185 exhibits a log2 fold change of -1.365 and an adjusted p-value of 0.01078. Which protein is encoded by this gene? | Membralin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02750","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), a gene downregulated by Zika virus and known to interact with RNF185 exhibits a... | |
medium_hidden_intermediate_02753 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and its expression is enriched in non-classical monocytes. This gene exhibits a log2 fold change of 1.054 and an adjusted p-value of 0.02595. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02753","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and i... | |
medium_hidden_intermediate_02754 | Rhinovirus A infection is associated with the upregulation of specific genes that are enriched in Mucosa-associated invariant T (MAIT) cells. One such gene exhibits a log2 fold change of approximately 2.03 and an adjusted p-value of 0.001783 in cytotoxic T-lymphocytes. Which protein is encoded by this gene? | Protein sprouty homolog 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02754","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection is associated with the upregulation of specific genes that are enriched in Mucosa-associated invarian... | |
medium_hidden_intermediate_02755 | Rhinovirus A infection upregulates certain genes that participate in the regulation of endogenous retroelements by KRAB-ZFP proteins. One such gene exhibits a log2 fold change of 1.968 and an adjusted p-value of 0.02835 in cytotoxic T-lymphocytes. Which protein is encoded by this specific gene? | Zinc finger protein 425 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02755","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection upregulates certain genes that participate in the regulation of endogenous retroelements by KRAB-ZFP ... | |
medium_hidden_intermediate_02757 | Enterovirus A is reported to downregulate a specific gene, which is located in the cytoplasm. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) indicate a log2 fold change of -1.313 and an adjusted p-value of 0.01855. Which disease is associated with this gene as a biomarker? | schizophrenia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02757","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is reported to downregulate a specific gene, which is located in the cytoplasm. Experimental data for this gen... | |
medium_hidden_intermediate_02759 | Cardiovirus A is reported to downregulate a gene that is located in the mitochondrial matrix. In a study of cervical adenocarcinoma cell lines (GSE122967), one such gene exhibited a log2 fold change of -1.049 and an adjusted p-value of 0.01904. Which protein does this specific gene product bind to? | HSD17B8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02759","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A is reported to downregulate a gene that is located in the mitochondrial matrix. In a study of cervical adenoca... | |
medium_hidden_intermediate_02762 | In a study of Measles morbillivirus infection, two genes are identified as being downregulated by the virus and involved in muscle contraction. One of these genes exhibits a log2 fold change of approximately -2.14 and an adjusted p-value of 0.0042. Which protein is encoded by this specific gene? | A-type potassium channel modulatory protein KCNIP2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02762","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, two genes are identified as being downregulated by the virus and involved in ... | |
medium_hidden_intermediate_02763 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene is downregulated and associated with hyperplasia. Evidence for this gene reports a log2 fold change of -1.282 and an adjusted p-value of 0.000489. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02763","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene is downregulat... | |
medium_hidden_intermediate_02764 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by the virus and interacts with YWHAZ. This gene exhibits a log2 fold change of approximately 2.50 and an adjusted p-value of approximately 4.21e-13. Which biological process is this gene involved in? | regulation of DNA-templated transcription | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02764","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by th... | |
medium_hidden_intermediate_02765 | Zika virus downregulates a specific gene that participates in cellular responses to stimuli. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -2.07 and an adjusted p-value of approximately 0.009. Which disease is associated with this gene as a biomarker? | cerebral infarction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02765","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in cellular responses to stimuli. Experimental data for this gene... | |
medium_hidden_intermediate_02766 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and to RPS5 via a 'binds' relationship. One of these genes is associated with experimental data showing a log2 fold change of approximately 1.333 and an adjusted p-value of 0.02196. Which protein... | Eukaryotic translation initiation factor 5B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02766","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship... | |
medium_hidden_intermediate_02767 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by the virus and its protein product interacts with UBC. This gene exhibits a log2 fold change of approximately 1.317 and an adjusted p-value of 4.932e-08. Which protein is encoded by this gene? | Zinc finger-containing ubiquitin peptidase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02767","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by th... | |
medium_hidden_intermediate_02768 | Human betaherpesvirus 5 is reported to downregulate a specific gene that participates in developmental biology. Experimental data for this gene in foreskin fibroblast cell lines indicates a log2 fold change of approximately -2.49 and an adjusted p-value of approximately 3.30e-06. Which disease is associated with this g... | benign neoplasm of large intestine | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02768","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a specific gene that participates in developmental biology. Experimental... | |
medium_hidden_intermediate_02769 | GPR37 interacts with a specific protein that enables protein binding. Evidence indicates this protein is involved in ER-to-Golgi trafficking and interacts with the TMD0 of TAPL via its transmembrane domain, an interaction that strongly depends on a newly identified salt bridge within TMD0. Which cell type is this prote... | conventional dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02769","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"GPR37 interacts with a specific protein that enables protein binding. Evidence indicates this protein is involved in ER-to-G... | |
medium_hidden_intermediate_02770 | In a study of glioma stem cells (GSE114907), a gene downregulated by Zika virus and involved in cellular responses to stimuli was found to have a log2 fold change of -1.145 and an adjusted p-value of 0.03907. Which gene binds to this specific entity? | WDR59 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02770","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), a gene downregulated by Zika virus and involved in cellular responses to stimul... | |
medium_hidden_intermediate_02771 | In a study of Measles morbillivirus infection, two genes are identified as being upregulated by the virus and participating in 'Signaling by Rho GTPases, Miro GTPases and RHOBTB3'. One of these genes exhibits a log2 fold change of approximately 1.166 and an adjusted p-value of 0.02703. Which protein is encoded by this ... | Oxysterol-binding protein-related protein 11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02771","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, two genes are identified as being upregulated by the virus and participating ... | |
medium_hidden_intermediate_02772 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by the virus and enables RNA binding. This gene exhibits a log2 fold change of 1.838 and an adjusted p-value of 2.546e-07. Which gene interacts with this upregulated entity? | SRPK2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02772","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by th... | |
medium_hidden_intermediate_02773 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in chromatin. Evidence for this gene reports a log2 fold change of 1.027 and an adjusted p-value of 0.0004188. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02773","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in chromatin. Evidence for this gen... | |
medium_hidden_intermediate_02775 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are located in lipid droplets. One of these genes shows a log2 fold change of 1.289 and an adjusted p-value of 5.05e-07 in lung cells. Which disease is associated with this specific gene? | congenital disorder of glycosylation, type 1DD | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02775","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are located in lipid droplets. One of... | |
medium_hidden_intermediate_02776 | Hepacivirus C downregulates a gene that enables transcription cis-regulatory region binding. Evidence for one such gene reports a log2 fold change of approximately -1.000 and an adjusted p-value of 0.02381. Which protein is encoded by that gene? | Zinc finger and BTB domain-containing protein 8A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02776","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a gene that enables transcription cis-regulatory region binding. Evidence for one such gene repo... | |
medium_hidden_intermediate_02777 | Zika virus downregulates a gene that participates in the MyD88-independent TLR4 cascade. Experimental data from glioma stem cells (study GSE114907) indicates that one such gene has a log2 fold change of approximately -1.976 and an adjusted p-value of 0.007326. Which protein is encoded by this specific gene? | NEDD4-binding protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02777","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in the MyD88-independent TLR4 cascade. Experimental data from glioma stem ... | |
medium_hidden_intermediate_02779 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes that subsequently interact with SRPK2. One such gene exhibited a log2 fold change of 1.428 and an adjusted p-value of 2.448e-07. Which protein is encoded by this specific gene? | Nucleolar GTP-binding protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02779","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes ... | |
medium_hidden_intermediate_02781 | Zika virus downregulates a gene that enables RNA polymerase II cis-regulatory region sequence-specific DNA binding. In a study of glioma stem cells (GSE114907), one such gene exhibits a log2 fold change of approximately -2.12 and an adjusted p-value of 0.01916. Which protein is encoded by this specific gene? | Zinc finger and SCAN domain-containing protein 21 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02781","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that enables RNA polymerase II cis-regulatory region sequence-specific DNA binding. In a stu... | |
medium_hidden_intermediate_02782 | In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus upregulates a specific gene that subsequently interacts with SMURF1. This gene exhibits a log2 fold change of approximately 1.106 and an adjusted p-value of 7.757e-08. Which disease is causally linked to this gene? | retinal degeneration | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02782","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus upregulates a specific gene that ... | |
medium_hidden_intermediate_02783 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the regulation of DNA-templated transcription. Experimental data for this gene reports a log2 fold change of -2.115 and an adjusted p-value of 0.03541. Which disease is associated with this gene as a biomarker? | hepatocellular carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02783","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the regulation of DNA-te... | |
medium_hidden_intermediate_02785 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene is upregulated by the virus and its product binds to TRAF2. This gene exhibits a log2 fold change of 1.433 and an adjusted p-value of 0.04217. Which protein is encoded by this gene? | Mitogen-activated protein kinase kinase kinase 14 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02785","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene is upregulated... | |
medium_hidden_intermediate_02786 | Human immunodeficiency virus 1 upregulates a gene that is enriched in Mucosa-associated invariant T (MAIT) cells. Evidence for this gene reports a log2 fold change of 1.397 and an adjusted p-value of 0.007093. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02786","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is enriched in Mucosa-associated invariant T (MAIT) cells. Evidence f... | |
medium_hidden_intermediate_02788 | Hepacivirus C upregulates a gene that is located in a protein-containing complex. Evidence for one such gene reports a log2 fold change of 1.463 and an adjusted p-value of 0.0002203. Which disease is associated with that gene? | gastric cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02788","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is located in a protein-containing complex. Evidence for one such gene reports a log2 ... | |
medium_hidden_intermediate_02789 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that subsequently binds to PDGFRA. Experimental data for one such gene reports a log2 fold change of -2.711 and an adjusted p-value of 0.0001258. Which protein is encoded by this gene? | Platelet-derived growth factor D | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02789","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that subsequently binds to PDGFRA. Experimental d... | |
medium_hidden_intermediate_02790 | FGFR1 interacts with a protein that enables protein binding. Evidence indicates that the SH2 domain of this specific protein binds to in vitro phosphorylated fibroblast growth factor receptor-1 (FGFR-1) mainly through position Y776. Which disease is associated with this protein as a biomarker? | melanoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02790","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"FGFR1 interacts with a protein that enables protein binding. Evidence indicates that the SH2 domain of this specific protein... | |
medium_hidden_intermediate_02791 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the RAF/MAP kinase cascade. One of these genes was reported in a study (GSE164073) on sclera cells with a log2 fold change of approximately 1.05 and an adjusted p-value of 0.0314. Which protein is encoded by this speci... | CAAX prenyl protease 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02791","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the RAF/MAP kinase cas... | |
medium_hidden_intermediate_02794 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in p75 NTR receptor-mediated signalling. One of these genes exhibits a log2 fold change of -1.009 and an adjusted p-value of 6.654e-05. Which protein interacts with this specific gene? | ARNT2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02794","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in p75 NTR receptor-med... | |
medium_hidden_intermediate_02795 | Zika virus downregulates a specific gene that subsequently interacts with ARHGEF2. Transcriptomic data for this gene in glioma stem cells (from study GSE114907) indicates a log2 fold change of -1.656 and an adjusted p-value of 0.0218. In which cell type is this gene reported to be enriched? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02795","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that subsequently interacts with ARHGEF2. Transcriptomic data for this gene in glio... | |
medium_hidden_intermediate_02797 | Zika virus downregulates a gene that participates in Golgi Associated Vesicle Biogenesis. Evidence for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -1.720 and an adjusted p-value of 0.01331. Which molecular function is enabled by this gene? | serine-type carboxypeptidase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02797","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in Golgi Associated Vesicle Biogenesis. Evidence for this gene in glioma s... | |
medium_hidden_intermediate_02800 | Hepacivirus C is linked to hypersensitivity reaction disease via a gene that is downregulated by the virus and associated with the disease. One such gene exhibits a log2 fold change of approximately -1.51 and an adjusted p-value of 0.0077 in peripheral blood mononuclear cells. Which protein is encoded by this gene? | 3-mercaptopyruvate sulfurtransferase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02800","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is linked to hypersensitivity reaction disease via a gene that is downregulated by the virus and associated wi... | |
medium_hidden_intermediate_02802 | Two genes are downregulated by Hepacivirus C and are involved in substantia nigra development. One of these genes exhibits a log2 fold change of approximately -1.23 and an adjusted p-value of 0.0179 in peripheral blood mononuclear cells from study GSE119117. What molecular function is enabled by this specific gene? | cytochrome-c oxidase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02802","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Hepacivirus C and are involved in substantia nigra development. One of these genes exhibits a... | |
medium_hidden_intermediate_02803 | Zika virus downregulates a specific gene, which in turn participates in cellular responses to stimuli. Transcriptomic data from glioma stem cells (study GSE114907) indicates that this gene has a log2 fold change of approximately -1.33 and an adjusted p-value of 0.0165. Which protein is encoded by this gene? | Signal peptide peptidase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02803","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn participates in cellular responses to stimuli. Transcriptomic data f... | |
medium_hidden_intermediate_02804 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes involved in the regulation of DNA replication. One such gene exhibited a log2 fold change of approximately 1.37 and an adjusted p-value of approximately 4.33e-07. Which protein is encoded by this ... | Actin-related protein 8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02804","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes ... | |
medium_hidden_intermediate_02806 | Human immunodeficiency virus 1 upregulates a gene that enables NAD+ nucleosidase activity, cyclic ADP-ribose generating. Evidence for one such gene reports a log2 fold change of 1.127 and an adjusted p-value of 0.004789. Which protein is encoded by that gene? | NAD(+) hydrolase SARM1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02806","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that enables NAD+ nucleosidase activity, cyclic ADP-ribose generating. Evi... | |
medium_hidden_intermediate_02807 | Pegivirus C is reported to downregulate a gene that enables sequence-specific double-stranded DNA binding. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.807 and an adjusted p-value of 0.000217. Which protein is encoded by this specific gene? | Cyclic AMP-responsive element-binding protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02807","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that enables sequence-specific double-stranded DNA binding. In a study of per... | |
medium_hidden_intermediate_02810 | Pegivirus C is reported to downregulate a specific gene, the product of which interacts with HSPA8. In a study of peripheral blood mononuclear cells (GSE131504), this gene exhibited a log2 fold change of -1.118 and an adjusted p-value of 0.03421. Which protein is encoded by this gene? | Myoferlin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02810","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, the product of which interacts with HSPA8. In a study of peripheral... | |
medium_hidden_intermediate_02813 | Zika virus upregulates a gene that is located in the extracellular exosome. Evidence for this gene in neural stem cells (study GSE129180) reports a log2 fold change of 1.219 and an adjusted p-value of 0.01749. Which disease is associated with this gene? | lung carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02813","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that is located in the extracellular exosome. Evidence for this gene in neural stem cells (stu... | |
medium_hidden_intermediate_02814 | PSMB9 is involved in a biological process that is a subtype of alpha-beta T cell activation involved in immune response. Evidence for one such process describes it as the process in which a relatively unspecialized T cell acquires the specialized features of a specific CD4-positive, alpha-beta T cell with the phenotype... | T-helper 17 cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02814","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"PSMB9 is involved in a biological process that is a subtype of alpha-beta T cell activation involved in immune response. Evi... | |
medium_hidden_intermediate_02817 | In a study of hepatoma cells infected with Dengue virus (GSE110512), a specific gene is upregulated and enables RNA binding. This gene exhibits a log2 fold change of approximately 1.597 and an adjusted p-value of 0.003128. Which protein is encoded by this gene? | Interferon-stimulated 20 kDa exonuclease-like 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02817","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of hepatoma cells infected with Dengue virus (GSE110512), a specific gene is upregulated and enables RNA binding.... | |
medium_hidden_intermediate_02818 | Pegivirus C is reported to downregulate a gene that is located in the nucleolus. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.549 and an adjusted p-value of 0.03987. Which protein does this specific gene product bind to? | MYF5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02818","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is located in the nucleolus. In a study of peripheral blood mononuclear ... | |
medium_hidden_intermediate_02820 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with EHD3. One of these genes has a reported log2 fold change of 1.349 and an adjusted p-value of 0.01047. Which protein is encoded by this specific gene? | Rab11 family-interacting protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02820","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with EHD3. One of these gene... | |
medium_hidden_intermediate_02821 | Human immunodeficiency virus 1 upregulates a gene that is involved in the ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Evidence for this gene in macrophages (study GSE108897) reports a log2 fold change of approximately 1.22 and an adjusted p-value of approximately 0.0035. W... | E3 ubiquitin-protein ligase RNF115 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02821","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is involved in the ubiquitin-dependent protein catabolic process via ... | |
medium_hidden_intermediate_02822 | Measles morbillivirus downregulates a gene that participates in lipid metabolism. Evidence for one such gene reports a log2 fold change of -1.209 and an adjusted p-value of 0.00405. Which protein is encoded by that gene? | Fatty acid-binding protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02822","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus downregulates a gene that participates in lipid metabolism. Evidence for one such gene reports a log2 ... | |
medium_hidden_intermediate_02823 | Hepacivirus C upregulates a gene that participates in Gastrulation. Evidence for one such gene reports a log2 fold change of 2.071 and an adjusted p-value of 2.71e-05. Which biological process is this gene involved in? | nervous system development | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02823","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in Gastrulation. Evidence for one such gene reports a log2 fold change of... | |
medium_hidden_intermediate_02824 | Zika virus downregulates a gene that is involved in the positive regulation of cell population proliferation. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -1.18 and an adjusted p-value of 0.014. Which protein is encoded by this gene? | tRNA-splicing ligase complex subunit FAM98B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02824","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the positive regulation of cell population proliferation. In a study of ... | |
medium_hidden_intermediate_02825 | Measles morbillivirus upregulates a gene that is located in the endoplasmic reticulum. Evidence for one such gene reports a log2 fold change of 1.426 and an adjusted p-value of 0.001582. Which protein is encoded by that gene? | Dermatan-sulfate epimerase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02825","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is located in the endoplasmic reticulum. Evidence for one such gene reports a ... | |
medium_hidden_intermediate_02826 | TRIM28 interacts with a nuclear protein that is associated with a specific disease. Evidence indicates that TRIM28 physically interacts with this protein, protecting it from proteasome-mediated degradation to suppress colorectal cancer (CRC) metastasis. Which disease is associated with this protein? | melanoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02826","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"TRIM28 interacts with a nuclear protein that is associated with a specific disease. Evidence indicates that TRIM28 physicall... | |
medium_hidden_intermediate_02828 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the regulation of the cell cycle. Evidence for this specific gene reports a log2 fold change of 1.146 and an adjusted p-value of 0.0001219. Which protein is encoded by this gene? | Zinc finger protein 703 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02828","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the regulation of the cell cycl... | |
medium_hidden_intermediate_02829 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to UBE2M via a binding relationship. One of these genes is associated with experimental data showing a log2 fold change of approximately 1.36 and an adjusted p-value of approximately 0.0038. W... | F-box/LRR-repeat protein 15 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02829","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship ... | |
medium_hidden_intermediate_02830 | Hepacivirus C is associated with the downregulation of a gene product that is located in the extracellular space. Transcriptomic data for one such entity indicates a log2 fold change of -2.269 and an adjusted p-value of 0.02235. Which protein is encoded by this specific gene? | Hepatocyte growth factor-like protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02830","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is associated with the downregulation of a gene product that is located in the extracellular space. Transcript... | |
medium_hidden_intermediate_02831 | Zika virus downregulates a specific gene, which is involved in endosomal transport. Experimental data from glioma stem cells (study GSE114907) indicates that this gene has a log2 fold change of -4.574 and an adjusted p-value of 0.02712. Which protein is encoded by this gene? | Sorting nexin-33 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02831","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which is involved in endosomal transport. Experimental data from glioma stem cells... | |
medium_hidden_intermediate_02832 | Hepacivirus C is linked to breast cancer via a gene that acts as a biomarker and is upregulated by the virus. One such gene exhibits a log2 fold change of 1.019 and an adjusted p-value of 0.01841 in hepatocytes. Which disease is associated with this specific gene? | peeling skin syndrome 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02832","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is linked to breast cancer via a gene that acts as a biomarker and is upregulated by the virus. One such gene ... | |
medium_hidden_intermediate_02834 | Pegivirus C is linked to the negative regulation of apoptotic process via two distinct intermediate genes, both of which are downregulated by the virus and involved in this biological process. One of these intermediate genes exhibits a log2 fold change of -1.601 and an adjusted p-value of 0.0002207 in peripheral blood ... | LATS1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02834","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is linked to the negative regulation of apoptotic process via two distinct intermediate genes, both of which are... | |
medium_hidden_intermediate_02837 | Pegivirus C is reported to downregulate a gene that participates in cGMP effects. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -2.39 and an adjusted p-value of approximately 0.034. Which protein does this specific gene product bind to? | ITPR1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02837","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that participates in cGMP effects. In a study of peripheral blood mononuclear... | |
medium_hidden_intermediate_02839 | A gene is upregulated by Primate bocaparvovirus 1 and participates in the Toll Like Receptor 7/8 (TLR7/8) Cascade. Experimental data for this gene in a non-Hodgkin lymphoma cell line (study GSE119608) reports a log2 fold change of 1.671 and an adjusted p-value of 0.02869. In which cell type is this gene enriched? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02839","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and participates in the Toll Like Receptor 7/8 (TLR7/8) Cascade. Experimen... | |
medium_hidden_intermediate_02840 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the synthesis of substrates in N-glycan biosynthesis. Evidence for this gene reports a log2 fold change of 1.427 and an adjusted p-value of 0.03696. Which biological process is this gene involved in? | CMP-N-acetylneuraminate biosynthetic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02840","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the synthesis of substrates in... | |
medium_hidden_intermediate_02843 | Human immunodeficiency virus 1 downregulates a gene that is involved in signal transduction. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of -2.298 and an adjusted p-value of 0.03336. Which cellular component is this gene located in? | extracellular space | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02843","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is involved in signal transduction. In a study of macrophages (GSE1... | |
medium_hidden_intermediate_02844 | Measles morbillivirus upregulates a gene that interacts with USP14. In study GSE131840, one such gene exhibits a log2 fold change of 1.148 and an adjusted p-value of 0.0004099. Which protein is encoded by this gene? | E3 ubiquitin-protein ligase TRIM11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02844","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that interacts with USP14. In study GSE131840, one such gene exhibits a log2 fold c... | |
medium_hidden_intermediate_02845 | Pegivirus C is reported to downregulate a specific gene, which is in turn associated with carcinoma. Experimental data for this gene in peripheral blood mononuclear cells (from study GSE131504) show a log2 fold change of -2.140 and an adjusted p-value of 0.0003104. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02845","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which is in turn associated with carcinoma. Experimental data for t... | |
medium_hidden_intermediate_02846 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which in turn interacts with MYC. The expression data for this intermediate gene shows a log2 fold change of approximately -1.25 and an adjusted p-value of 0.02443. Which protein is enco... | Protein lin-54 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02846","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_02847 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a gene that enables histone H3K36 demethylase activity. One such gene exhibited a log2 fold change of 1.184 and an adjusted p-value of 0.0002551. Which protein is encoded by this specific gene? | Lysine-specific demethylase 2B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02847","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a gene that enables histon... | |
medium_hidden_intermediate_02849 | In a study of Influenza A virus infection, a specific gene is downregulated and participates in the biological process 'Phase II - Conjugation of compounds'. Experimental data for this gene reports a log2 fold change of -2.875 and an adjusted p-value of 5.207e-06. Which cellular component is this gene located in? | cytosol | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02849","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is downregulated and participates in the biological process 'Phas... | |
medium_hidden_intermediate_02853 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with glioma. One of these genes exhibits a log2 fold change of 3.872 and an adjusted p-value of 0.01152 in a specific study. Which biological process is this gene involved in? | small GTPase-mediated signal transduction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02853","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with glioma. One of th... |
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