qa_id stringlengths 24 32 | question stringlengths 156 1.14k | answer stringlengths 3 134 | level stringclasses 1
value | subtype stringclasses 3
values | source_medium_qa_id stringclasses 1
value | record_json stringlengths 13.6k 214k |
|---|---|---|---|---|---|---|
medium_hidden_intermediate_02854 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and serve as biomarkers for rheumatoid arthritis. One of these genes exhibits a log2 fold change of approximately 1.002 and an adjusted p-value of 0.006407 in a specific study context. Which disease is associated with this specific gene? | amyloidosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02854","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and serve as biomarkers for rheumatoid ar... | |
medium_hidden_intermediate_02855 | Pegivirus C is reported to downregulate a gene that participates in Complex IV assembly. In a study of peripheral blood mononuclear cells (GSE131504), one such gene showed a log2 fold change of approximately -1.445 and an adjusted p-value of 0.01045. Which disease is associated with this specific gene? | intervertebral disk degenerative disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02855","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that participates in Complex IV assembly. In a study of peripheral blood mono... | |
medium_hidden_intermediate_02857 | Zika virus downregulates a specific gene, which in turn interacts with FGFR1. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.48 and an adjusted p-value of 0.0117. Which protein is encoded by this gene? | PDZ domain-containing protein 8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02857","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with FGFR1. Experimental data for this gene in glioma stem... | |
medium_hidden_intermediate_02859 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables protein kinase binding. Experimental data for this gene shows a log2 fold change of approximately 4.75 and an adjusted p-value of 0.0031. Which cellular component is this gene located in? | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02859","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables protein kinase binding. Experimental d... | |
medium_hidden_intermediate_02860 | Hepacivirus C upregulates a gene that participates in the metabolism of amino acids and derivatives. Evidence for one such gene reports a log2 fold change of 4.327 and an adjusted p-value of 0.01991. Which disease is connected to that gene through genomic alterations? | Glutamate formiminotransferase deficiency | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02860","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in the metabolism of amino acids and derivatives. Evidence for one such g... | |
medium_hidden_intermediate_02861 | Two genes are upregulated by Human immunodeficiency virus 1 and interact with SQSTM1. One of these genes exhibits a log2 fold change of 1.656 and an adjusted p-value of 1.197e-05 in a specific study. Which biological process is this gene involved in? | protein folding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02861","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and interact with SQSTM1. One of these genes exhibits a log2 fol... | |
medium_hidden_intermediate_02863 | Two genes are upregulated by Vaccinia virus and associated with schizophrenia. One of these genes exhibits a log2 fold change of 7.135 and an adjusted p-value of 1.23e-08 in cervical adenocarcinoma cell lines. Which cellular component is the location of this specific gene? | perinuclear region of cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02863","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and associated with schizophrenia. One of these genes exhibits a log2 fold chang... | |
medium_hidden_intermediate_02864 | Hepacivirus C upregulates a gene that is involved in the defense response to Gram-positive bacteria. Experimental data for this gene in liver tissue (study GSE12720) shows a log2 fold change of approximately 4.11 and an adjusted p-value of 3.938e-05. Which protein is encoded by this gene? | Neutrophil defensin 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02864","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in the defense response to Gram-positive bacteria. Experimental data for t... | |
medium_hidden_intermediate_02865 | Zika virus downregulates a specific gene that subsequently interacts with HNRNPU. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -2.005 and an adjusted p-value of 0.04324. Which biological process is this gene involved in? | RNA methylation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02865","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that subsequently interacts with HNRNPU. Experimental data for this gene in glioma ... | |
medium_hidden_intermediate_02866 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate genes involved in GDP-fucose biosynthesis. One such gene exhibited a log2 fold change of 1.546 and an adjusted p-value of 3.344e-06. Which protein is encoded by this specific gene? | Fucose-1-phosphate guanylyltransferase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02866","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate genes involved... | |
medium_hidden_intermediate_02868 | Two genes are each upregulated by Severe acute respiratory syndrome-related coronavirus and associated with melanoma. One of these genes was reported in a study (GSE164073) with a log2 fold change of approximately 1.107 and an adjusted p-value of approximately 0.0006. Which protein does this specific gene interact with... | CALM1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02868","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each upregulated by Severe acute respiratory syndrome-related coronavirus and associated with melanoma. One of... | |
medium_hidden_intermediate_02869 | A gene is upregulated by Vaccinia virus and participates in Dengue Virus Infection. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of 8.833 and an adjusted p-value of 0.0001119. Which disease is associated with this gene as a biomarker? | non-small cell lung carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02869","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Vaccinia virus and participates in Dengue Virus Infection. Experimental data for this gene in a cer... | |
medium_hidden_intermediate_02870 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with FGFR1. Evidence for one such gene reports a log2 fold change of 1.117 and an adjusted p-value of 0.04706. Which protein is encoded by that gene? | Nucleotidyltransferase MB21D2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02870","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with FGFR1. Evidence for one such ge... | |
medium_hidden_intermediate_02873 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables ATP binding. Experimental data for this gene shows a log2 fold change of approximately 1.129 and an adjusted p-value of 0.01076. Which cellular component is this gene located in? | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02873","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables ATP binding. Experimental data fo... | |
medium_hidden_intermediate_02874 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the epigenetic regulation of gene expression by MLL3 and MLL4 complexes. Evidence for this gene reports a log2 fold change of 2.835 and an adjusted p-value of 0.01542. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02874","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the epigenetic regulation... | |
medium_hidden_intermediate_02875 | In a study of Measles morbillivirus infection, a specific gene is downregulated by the virus and participates in organelle biogenesis and maintenance. Evidence for this gene reports a log2 fold change of -1.169 and an adjusted p-value of 0.01672. Which protein is encoded by this gene? | ATP synthase subunit s, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02875","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is downregulated by the virus and participates in organelle b... | |
medium_hidden_intermediate_02876 | Human immunodeficiency virus 1 upregulates a gene that participates in the metabolism of steroids. Evidence for this gene reports a log2 fold change of 1.020 and an adjusted p-value of 0.000213. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02876","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in the metabolism of steroids. Evidence for this gene re... | |
medium_hidden_intermediate_02878 | Human alphaherpesvirus 3 upregulates a gene that is located in the nucleus. Evidence for this specific gene in a melanoma cell line (study GSE136586) reports a log2 fold change of 1.371 and an adjusted p-value of 3.922e-05. Which disease is associated with genomic alterations in this gene? | diabetes mellitus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02878","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 upregulates a gene that is located in the nucleus. Evidence for this specific gene in a melanoma ce... | |
medium_hidden_intermediate_02879 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in the RHO GTPase cycle. Evidence for this gene reports a log2 fold change of -1.309 and an adjusted p-value of 0.02901. Which gene interacts with this downregulated gene? | AHNAK | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02879","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in the RHO GTPase cycle. Eviden... | |
medium_hidden_intermediate_02880 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the positive regulation of the apoptotic process. Evidence for one such gene reports a log2 fold change of 3.663 and an adjusted p-value of 0.008239. Which protein is encoded by that gene? | Pleckstrin homology domain-containing family N member 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02880","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the positive regulation of the ... | |
medium_hidden_intermediate_02882 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that enables potassium channel activity. Experimental data for this gene in lung cells shows a log2 fold change of -2.195 and an adjusted p-value of 0.0003866. Which protein is encoded by this gene? | Potassium channel subfamily K member 13 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02882","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that enables potassium channel activity. Experime... | |
medium_hidden_intermediate_02886 | Zika virus downregulates a gene that is involved in mitotic cytokinesis. In a study of glioma stem cells (GSE114907), one such gene showed a log2 fold change of -1.791 and an adjusted p-value of 0.02349. Which protein is encoded by this gene? | Exocyst complex component 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02886","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in mitotic cytokinesis. In a study of glioma stem cells (GSE114907), one su... | |
medium_hidden_intermediate_02889 | A genetic variant, NM_015600.4(ABHD12):c.-6898_191+7002delinsCC, is linked to a gene that is part of the voltage-gated calcium channel complex. Experimental evidence indicates that in human embryonic kidney 293 cells, the alpha(2)delta-4 subunit associated with Ca(V)1.2 and beta(3) subunits significantly increased Ca(V... | Voltage-dependent calcium channel subunit alpha-2/delta-4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02889","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A genetic variant, NM_015600.4(ABHD12):c.-6898_191+7002delinsCC, is linked to a gene that is part of the voltage-gated calci... | |
medium_hidden_intermediate_02892 | A gene is downregulated by Cardiovirus A and participates in a disease. Evidence for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of -2.145 and an adjusted p-value of 0.02262. Which disease is connected to this gene through genomic alterations? | melanoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02892","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Cardiovirus A and participates in a disease. Evidence for this gene in a cervical adenocarcinoma ... | |
medium_hidden_intermediate_02894 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that is located in the peroxisome. One such gene exhibits a log2 fold change of 1.020 and an adjusted p-value of 0.000213. Which protein is encoded by this specific gene? | Isopentenyl-diphosphate Delta-isomerase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02894","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that is located in the peroxisome. ... | |
medium_hidden_intermediate_02897 | Two genes are upregulated by Measles morbillivirus and enriched in non-classical monocytes. One of these genes has a reported log2 fold change of 1.664 and an adjusted p-value of 0.04641. Which disease is associated with this specific gene as a biomarker? | breast cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02897","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Measles morbillivirus and enriched in non-classical monocytes. One of these genes has a reporte... | |
medium_hidden_intermediate_02900 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with HIST1H4A. One of these genes shows a log2 fold change of 1.229 and an adjusted p-value of 0.04776 in a specific study. Which disease is associated with this gene? | acute myeloid leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02900","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with HIST1H4A. One of these ... | |
medium_hidden_intermediate_02901 | Hepacivirus C upregulates a gene that is involved in the negative regulation of DNA-templated transcription. Evidence for this gene in a specific study reports a log2 fold change of approximately 1.39 and an adjusted p-value of 0.00065. In which cell type is this gene enriched? | conventional dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02901","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in the negative regulation of DNA-templated transcription. Evidence for th... | |
medium_hidden_intermediate_02902 | Hepacivirus C is reported to downregulate a gene that is involved in microtubule cytoskeleton organization. Experimental data for this gene show a log2 fold change of -1.256 and an adjusted p-value of 0.01491. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02902","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that is involved in microtubule cytoskeleton organization. Experimental dat... | |
medium_hidden_intermediate_02903 | Human alphaherpesvirus 1 is known to downregulate certain genes that are involved in the positive regulation of tyrosine phosphorylation of STAT protein. One such gene exhibits a log2 fold change of -2.262 and an adjusted p-value of 0.02394 in a monocytic leukemia cell line (study GSE114966). Which protein is encoded b... | Tumor necrosis factor ligand superfamily member 18 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02903","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 is known to downregulate certain genes that are involved in the positive regulation of tyrosine pho... | |
medium_hidden_intermediate_02904 | A gene is downregulated by Primate bocaparvovirus 1 and is involved in the negative regulation of the apoptotic process. Experimental evidence for this gene reports a log2 fold change of -1.722 and an adjusted p-value of 0.002869. Which protein is encoded by this gene? | Serine/threonine-protein kinase PLK3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02904","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and is involved in the negative regulation of the apoptotic process. Exp... | |
medium_hidden_intermediate_02907 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, which in turn interacts with PLEKHA5. This gene exhibited a log2 fold change of 2.593 and an adjusted p-value of 2.753e-05. Which protein is encoded by this upregulated gene? | PDZ domain-containing protein 11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02907","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_02909 | Zika virus infection has been shown to downregulate multiple genes involved in the S-adenosylmethionine biosynthetic process. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -1.587 and an adjusted p-value of 0.002914. Which protein is encoded by this specific gene? | S-adenosylmethionine synthase isoform type-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02909","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection has been shown to downregulate multiple genes involved in the S-adenosylmethionine biosynthetic process... | |
medium_hidden_intermediate_02910 | Cholecystokinin (CCK) binds to a specific receptor that participates in the function of peptide ligand-binding receptors. Experimental evidence indicates that probes bound to type B CCK receptors in a saturable and specific manner, acting as full agonists. Which protein is encoded by the gene corresponding to this rece... | Gastrin/cholecystokinin type B receptor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02910","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cholecystokinin (CCK) binds to a specific receptor that participates in the function of peptide ligand-binding receptors. Ex... | |
medium_hidden_intermediate_02911 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the Mitotic Cell Cycle. Experimental evidence for this gene reports a log2 fold change of 1.015 and an adjusted p-value of 0.009804. Which protein is encoded by this gene? | Nuclear envelope phosphatase-regulatory subunit 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02911","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the Mitotic Cell Cycle. E... | |
medium_hidden_intermediate_02912 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is associated with schizophrenia. Evidence for this gene reports a log2 fold change of -1.159 and an adjusted p-value of 0.001277. Which protein is encoded by this gene? | Peroxisomal N(1)-acetyl-spermine/spermidine oxidase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02912","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is associated with schizophrenia. Evide... | |
medium_hidden_intermediate_02914 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which in turn encodes a protein that binds to GOSR1. The downregulated gene exhibits a log2 fold change of approximately -1.83 and an adjusted p-value of 0.016. Which protein is encoded ... | Golgi integral membrane protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02914","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_02915 | Pegivirus C downregulates a gene that participates in macroautophagy. In a study of peripheral blood mononuclear cells (GSE131504), this gene exhibited a log2 fold change of approximately -1.102 and an adjusted p-value of 0.02943. Which protein does this gene interact with? | MAP1LC3B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02915","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that participates in macroautophagy. In a study of peripheral blood mononuclear cells (GSE1... | |
medium_hidden_intermediate_02918 | Human immunodeficiency virus 1 upregulates a gene that enables protein homodimerization activity. In a study of macrophages (GSE108897), one such gene showed a log2 fold change of 2.392 and an adjusted p-value of 3.946e-05. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02918","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that enables protein homodimerization activity. In a study of macrophages ... | |
medium_hidden_intermediate_02919 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are enriched in CD4-positive, alpha-beta memory T cells. One of these genes exhibits a log2 fold change of 3.839 and an adjusted p-value of 0.004356 in lung tissue. Which disease is associated with this specific gene? | cerebral infarction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02919","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are enriched in CD4-positive, alpha-b... | |
medium_hidden_intermediate_02920 | In a study of rhabdomyosarcoma cells, a gene is upregulated by Enterovirus A and interacts with YWHAB. Evidence for this gene reports a log2 fold change of 1.611 and an adjusted p-value of 0.0428. Which protein is encoded by this gene? | Protein Smaug homolog 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02920","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells, a gene is upregulated by Enterovirus A and interacts with YWHAB. Evidence for this gen... | |
medium_hidden_intermediate_02921 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and interacts with SRC. Experimental data for this gene in choroid plexus epithelium shows a log2 fold change of approximately -3.08 and an adjusted p-value of 0.000865. Which biological process is this gene involved in? | intracellular signal transduction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02921","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and interacts with SRC. Experimental data f... | |
medium_hidden_intermediate_02924 | Human betaherpesvirus 5 upregulates a gene that participates in the metabolism of carbohydrates and carbohydrate derivatives. Experimental data for this gene in foreskin fibroblast cell lines (study GSE130665) reports a log2 fold change of approximately 1.28 and an adjusted p-value of 1.38e-05. Which protein is encoded... | Glucosamine-6-phosphate deaminase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02924","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that participates in the metabolism of carbohydrates and carbohydrate derivatives... | |
medium_hidden_intermediate_02925 | In a study of peripheral blood mononuclear cells (GSE119117), Hepacivirus C infection was found to downregulate a specific gene involved in the doxorubicin metabolic process. This gene exhibited a log2 fold change of approximately -1.143 and an adjusted p-value of 0.0002513. Which protein is encoded by this gene? | Aldo-keto reductase family 1 member B10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02925","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of peripheral blood mononuclear cells (GSE119117), Hepacivirus C infection was found to downregulate a specific g... | |
medium_hidden_intermediate_02926 | In a study of vascular endothelial cells (GSE16354), a gene is upregulated by Human gammaherpesvirus 8 and participates in fatty acid metabolism. This gene exhibits a log2 fold change of approximately 1.53 and an adjusted p-value of approximately 0.0066. Which protein is encoded by this gene? | 3-ketoacyl-CoA thiolase, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02926","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of vascular endothelial cells (GSE16354), a gene is upregulated by Human gammaherpesvirus 8 and participates in f... | |
medium_hidden_intermediate_02927 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables phospholipid scramblase activity. Evidence for one such gene reports a log2 fold change of 1.294 and an adjusted p-value of 3.312e-14. Which protein is encoded by that gene? | Phospholipid scramblase 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02927","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables phospholipid scramblase activity. Evid... | |
medium_hidden_intermediate_02929 | In a study of Hepacivirus C infection in hepatocytes (GSE132606), a specific gene is upregulated by the virus and is involved in protein maturation. This gene exhibits a log2 fold change of approximately 1.159 and an adjusted p-value of 0.03386. Which protein is encoded by this gene? | Cytosolic iron-sulfur assembly component 2B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02929","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Hepacivirus C infection in hepatocytes (GSE132606), a specific gene is upregulated by the virus and is involve... | |
medium_hidden_intermediate_02930 | Two genes are upregulated by Human immunodeficiency virus 1 and enriched in intermediate monocytes. One of these genes exhibits a log2 fold change of approximately 1.306 and an adjusted p-value of 8.957e-05 in macrophages. Which biological process is this specific gene involved in? | hypoxanthine transport | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02930","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and enriched in intermediate monocytes. One of these genes exhib... | |
medium_hidden_intermediate_02931 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in protein O-linked glycosylation via mannose. Evidence for one such gene reports a log2 fold change of 2.423 and an adjusted p-value of 9.721e-11. Which protein is encoded by that gene? | Protein O-mannosyl-transferase TMTC1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02931","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in protein O-linked glycosylation ... | |
medium_hidden_intermediate_02932 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with NFIX. Experimental data for this gene reports a log2 fold change of approximately 1.002 and an adjusted p-value of 0.01899. Which biological process is this gene involved in? | negative regulation of DNA-templated transcription | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02932","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with NFIX. Experimental data fo... | |
medium_hidden_intermediate_02934 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with neuroblastoma. One of these genes exhibits a log2 fold change of -2.576 and an adjusted p-value of 0.02349 in a specific study. Which cell type is enriched for this specific gene? | mucosal-associated invariant T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02934","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with neuroblastoma. ... | |
medium_hidden_intermediate_02935 | Zika virus downregulates a specific gene, which in turn interacts with YWHAH. Transcriptomic data from glioma stem cells (study GSE114907) indicates that this gene has a log2 fold change of approximately -4.85 and an adjusted p-value of 0.016. What molecular function is enabled by this gene? | actin binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02935","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with YWHAH. Transcriptomic data from glioma stem cells (st... | |
medium_hidden_intermediate_02936 | In a study of vascular endothelial cells (GSE16354), a gene is downregulated by Human gammaherpesvirus 8 and participates in Class A/1 (Rhodopsin-like receptors). Evidence for this gene shows a log2 fold change of approximately -4.14 and an adjusted p-value of 0.0022. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02936","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of vascular endothelial cells (GSE16354), a gene is downregulated by Human gammaherpesvirus 8 and participates in... | |
medium_hidden_intermediate_02939 | Two genes are downregulated by Pegivirus C and are enriched in naive CD8+ T cells. One of these genes exhibits a log2 fold change of -1.275 and an adjusted p-value of 0.01101 in peripheral blood mononuclear cells (study GSE131504). Which protein interacts with this specific gene product? | SLC39A7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02939","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and are enriched in naive CD8+ T cells. One of these genes exhibits a log2 fold c... | |
medium_hidden_intermediate_02941 | Zika virus downregulates a specific gene, which in turn interacts with CCT6A. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.63 and an adjusted p-value of approximately 0.0042. Which disease is associated with this gene as a biomarker? | prostate carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02941","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with CCT6A. Experimental data for this gene in glioma stem... | |
medium_hidden_intermediate_02942 | A gene is upregulated by Primate bocaparvovirus 1 and enables fatty acyl-CoA hydrolase activity. Evidence for this gene reports a log2 fold change of 1.200 and an adjusted p-value of 0.03332. Which cellular component is this gene located in? | peroxisome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02942","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and enables fatty acyl-CoA hydrolase activity. Evidence for this gene repo... | |
medium_hidden_intermediate_02943 | A gene serves as a marker for microglial cells and is enriched in plasmacytoid dendritic cells. Evidence for this gene includes a mean expression of 2113.89 TPM, a z-score of 3.15, and a fold enrichment of 5.13. Which disease is associated with this gene as a biomarker? | alcohol abuse | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02943","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for microglial cells and is enriched in plasmacytoid dendritic cells. Evidence for this gene inclu... | |
medium_hidden_intermediate_02944 | In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and enriched in basophils. This specific gene exhibits a log2 fold change of 1.536 and an adjusted p-value of 0.03369. Which molecular function is enabled by this gene? | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02944","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and enriched in... | |
medium_hidden_intermediate_02945 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the response to elevated platelet cytosolic Ca2+. One of these genes exhibits a log2 fold change of approximately 3.80 and an adjusted p-value of 6.954e-05 in lung tissue. Which protein interacts with this specific gen... | TMPRSS2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02945","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the response to elevat... | |
medium_hidden_intermediate_02947 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in Cytokine Signaling in the Immune system. Evidence for this gene reports a log2 fold change of -1.583 and an adjusted p-value of 0.01782. Which protein is encoded by this gene? | Pro-interleukin-16 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02947","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in Cytokine Signaling in the Im... | |
medium_hidden_intermediate_02948 | Pegivirus C is reported to downregulate a gene that enables phosphatidylinositol-4-phosphate binding. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -1.505 and an adjusted p-value of 0.01478. Which protein is encoded by this specific gene? | Oxysterol-binding protein-related protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02948","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that enables phosphatidylinositol-4-phosphate binding. In a study of peripher... | |
medium_hidden_intermediate_02951 | Zika virus downregulates a gene that is involved in the negative regulation of retrograde protein transport from the ER to the cytosol. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -1.737 and an adjusted p-value of 0.00512. Which protein is encoded by this specific gene? | Ubiquitin-conjugating enzyme E2 J1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02951","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the negative regulation of retrograde protein transport from the ER to t... | |
medium_hidden_intermediate_02953 | Two genes are upregulated by Enterovirus A and participate in phospholipid metabolism. One of these genes shows a log2 fold change of approximately 1.13 and an adjusted p-value of approximately 0.00069 in rhabdomyosarcoma cells. Which cell type is enriched for the expression of this specific gene? | naive thymus-derived CD8-positive, alpha-beta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02953","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Enterovirus A and participate in phospholipid metabolism. One of these genes shows a log2 fold ... | |
medium_hidden_intermediate_02954 | Rhinovirus A infection leads to the downregulation of certain genes involved in the defense response to Gram-negative bacteria. One such gene exhibits a log2 fold change of approximately -1.58 and an adjusted p-value of 0.0026 in cytotoxic T-lymphocytes. Which protein is encoded by this specific gene? | Ribonuclease K6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02954","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection leads to the downregulation of certain genes involved in the defense response to Gram-negative bacter... | |
medium_hidden_intermediate_02955 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with ANLN. One of these genes exhibits a log2 fold change of -1.769 and an adjusted p-value of 0.001751 in a specific study. What molecular function is enabled by this specific gene? | actin binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02955","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with ANLN. One of these ge... | |
medium_hidden_intermediate_02956 | Two genes are downregulated by Pegivirus C and participate in Sphingolipid metabolism. One of these genes exhibits a log2 fold change of -1.179 and an adjusted p-value of 0.00094 in peripheral blood mononuclear cells. Which cell type is enriched for this specific gene? | classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02956","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and participate in Sphingolipid metabolism. One of these genes exhibits a log2 fo... | |
medium_hidden_intermediate_02957 | Two genes are linked to Vaccinia virus via upregulation and to juvenile myoclonic epilepsy via genomic alterations. One of these genes exhibits a log2 fold change of approximately 2.275 and an adjusted p-value of 8.708e-07 in cervical adenocarcinoma cell lines. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02957","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Vaccinia virus via upregulation and to juvenile myoclonic epilepsy via genomic alterations. One of t... | |
medium_hidden_intermediate_02958 | Zaire ebolavirus upregulates a gene that is located in the nucleus. In a study of retinal pigment epithelium cells (GSE100839), this gene exhibited a log2 fold change of 5.077 and an adjusted p-value of 1.351e-05. Which disease is associated with genomic alterations in this specific gene? | prostate carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02958","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus upregulates a gene that is located in the nucleus. In a study of retinal pigment epithelium cells (GSE10083... | |
medium_hidden_intermediate_02959 | Measles morbillivirus upregulates a gene that participates in Signaling by Rho GTPases. Evidence for this gene reports a log2 fold change of approximately 3.04 and an adjusted p-value of approximately 0.015. Which cellular component is this gene located in? | focal adhesion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02959","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that participates in Signaling by Rho GTPases. Evidence for this gene reports a log... | |
medium_hidden_intermediate_02960 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, which in turn interacts with HRAS. This gene exhibited a log2 fold change of approximately 4.31 and an adjusted p-value of 6.87e-11. Which protein is encoded by this upregulated gene? | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02960","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_02961 | A gene is upregulated by Enterovirus A and enriched in memory B cells. Evidence for this gene in rhabdomyosarcoma cells (study GSE103308) reports a log2 fold change of approximately 1.73 and an adjusted p-value of 0.0175. Which protein is encoded by this gene? | Protein sel-1 homolog 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02961","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Enterovirus A and enriched in memory B cells. Evidence for this gene in rhabdomyosarcoma cells (stu... | |
medium_hidden_intermediate_02963 | Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to RAC1 via an 'interacts with' relationship. One of these genes exhibits a log2 fold change of approximately -5.16 and an adjusted p-value of approximately 0.0087 in a specific study. Which cell type is this gene... | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02963","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to RAC1 via an 'i... | |
medium_hidden_intermediate_02964 | A gene serves as a marker for Follicular B cells and is enriched in memory B cells. Evidence for this gene includes a mean expression of 15.62 TPM, a z-score of 2.86, and a fold enrichment of 16.90. Which disease is associated with this gene through genomic alterations? | coronary artery disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02964","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for Follicular B cells and is enriched in memory B cells. Evidence for this gene includes a mean e... | |
medium_hidden_intermediate_02967 | Hepacivirus C is linked to colitis via a gene that it downregulates and which is associated with the disease. One such gene exhibits a log2 fold change of -1.203 and an adjusted p-value of 0.04307. Which cell type is this gene enriched in? | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02967","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is linked to colitis via a gene that it downregulates and which is associated with the disease. One such gene ... | |
medium_hidden_intermediate_02969 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by the virus and is involved in DNA repair. This gene exhibits a log2 fold change of approximately 1.182 and an adjusted p-value of 1.108e-09. Which protein is encoded by this gene? | Zinc finger and BTB domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02969","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by th... | |
medium_hidden_intermediate_02971 | ZNF24 interacts with a protein that enables RNA polymerase II cis-regulatory region sequence-specific DNA binding. Evidence indicates that ZNF24 was identified as a novel heterodimeric partner of this protein, which also associates with PML-NBs in a unique ring-type pattern. Which protein is encoded by the gene corresp... | Myeloid zinc finger 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02971","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"ZNF24 interacts with a protein that enables RNA polymerase II cis-regulatory region sequence-specific DNA binding. Evidence ... | |
medium_hidden_intermediate_02972 | Human alphaherpesvirus 3 upregulates a gene that participates in the metabolism of lipids. In a study of melanoma cell lines (GSE136586), one such gene exhibited a log2 fold change of approximately 1.82 and an adjusted p-value of approximately 1.97e-05. Which biological process is this specific gene involved in? | sphingosine metabolic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02972","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 upregulates a gene that participates in the metabolism of lipids. In a study of melanoma cell lines... | |
medium_hidden_intermediate_02974 | A gene is downregulated by Primate bocaparvovirus 1 and participates in the metabolism of water-soluble vitamins and cofactors. Experimental evidence for this gene reports a log2 fold change of -2.291 and an adjusted p-value of 0.03604. Which disease is associated with this gene through genomic alterations? | metabolic dysfunction-associated steatohepatitis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02974","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and participates in the metabolism of water-soluble vitamins and cofacto... | |
medium_hidden_intermediate_02975 | In a study of macrophages (GSE108897), a gene is identified as being upregulated by Human immunodeficiency virus 1 and serving as a biomarker for schizophrenia. This specific gene exhibits a log2 fold change of approximately 1.158 and an adjusted p-value of 0.01115. Which protein is encoded by this gene? | Thymosin beta-10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02975","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified as being upregulated by Human immunodeficiency virus 1 and servi... | |
medium_hidden_intermediate_02979 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and to MCM4 via a 'binds' relationship. One of these genes has been reported in a study (GSE148729) with a log2 fold change of approximately 2.152 and an adjusted p-value of 0.01545. Which cell t... | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02979","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship... | |
medium_hidden_intermediate_02980 | PARP1 interacts with a specific protein, which in turn interacts with RELA. Experimental evidence indicates that while Parp2 interacts significantly with this protein (identified as a transition chaperone) and the transition protein TP2, Parp1 binds to it only weakly. Which disease is associated with this protein? | oligospermia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02980","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"PARP1 interacts with a specific protein, which in turn interacts with RELA. Experimental evidence indicates that while Parp2... | |
medium_hidden_intermediate_02981 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, which is subsequently involved in the regulation of cilium assembly. This gene exhibited a log2 fold change of approximately 1.06 and an adjusted p-value of 1.801e-07. Which protein is encoded ... | Dynein light chain Tctex-type protein 2B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02981","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_02983 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in neutrophil chemotaxis. One of these genes exhibits a log2 fold change of 3.116 and an adjusted p-value of 0.00276 in lung tissue. Which cell type is enriched for this specific gene? | gamma-delta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02983","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in neutrophil chemotaxis... | |
medium_hidden_intermediate_02984 | A specific gene product is identified as a marker for Central memory T cells and is known to enable protein binding. Experimental evidence indicates that this entity specifically interacts with the armadillo repeats of importin α in a Ca(2+)-dependent manner, as demonstrated by GST pull-down, gel-shift, and co-immunopr... | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02984","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A specific gene product is identified as a marker for Central memory T cells and is known to enable protein binding. Experim... | |
medium_hidden_intermediate_02985 | In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated and its product is located in the lysosomal membrane. This gene exhibits a log2 fold change of 3.171 and an adjusted p-value of 4.58e-11. Which protein is encoded by this gene? | Scavenger receptor class B member 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02985","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated and its product is ... | |
medium_hidden_intermediate_02986 | Human immunodeficiency virus 1 is reported to downregulate a gene that is involved in cognition. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of approximately -1.23 and an adjusted p-value of approximately 0.015. Which protein is encoded by this specific gene? | Neuronal acetylcholine receptor subunit alpha-7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02986","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 is reported to downregulate a gene that is involved in cognition. In a study of macrophages (... | |
medium_hidden_intermediate_02988 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with melanoma. One of these genes exhibits a log2 fold change of 2.484 and an adjusted p-value of 7.354e-06 in lung tissue data from study GSE148697. Which cell type is enriched for this specific gene? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02988","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with melanoma. One of ... | |
medium_hidden_intermediate_02992 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that enables zinc ion binding. One such gene exhibits a log2 fold change of approximately 1.406 and an adjusted p-value of 0.00689. Which protein is encoded by this specific gene? | Methionine-R-sulfoxide reductase B2, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02992","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that enables zinc ion binding. One ... | |
medium_hidden_intermediate_02993 | Measles morbillivirus downregulates a gene that is enriched in conventional dendritic cells. Evidence for one such gene reports a log2 fold change of -1.164 and an adjusted p-value of 0.001061. Which protein is encoded by that gene? | Nudix hydrolase 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02993","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus downregulates a gene that is enriched in conventional dendritic cells. Evidence for one such gene repo... | |
medium_hidden_intermediate_02994 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to CCNF via an 'interacts with' relationship. One of these genes has been reported in a study (GSE157852) involving choroid plexus epithelium, with a log2 fold change of approximately -1.01 ... | nodular goiter | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02994","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_02995 | In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upregulate certain genes involved in proteolysis. One such gene exhibited a log2 fold change of 1.384 and an adjusted p-value of 0.009859. Which protein is encoded by this specific gene? | Dipeptidyl peptidase 8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02995","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upreg... | |
medium_hidden_intermediate_02996 | Zika virus downregulates a gene that participates in the Unfolded Protein Response (UPR). Experimental data for this gene reports a log2 fold change of -1.228 and an adjusted p-value of 0.02683. Which protein is encoded by this gene? | Exostosin-like 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02996","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in the Unfolded Protein Response (UPR). Experimental data for this gene re... | |
medium_hidden_intermediate_02997 | In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection was found to upregulate a specific gene that is involved in the regulation of DNA-templated transcription. This gene exhibited a log2 fold change of 2.735 and an adjusted p-value of 5.883e-07. Which disease is associate... | thyroid tumor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_02997","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection was found to upregulate... | |
medium_hidden_intermediate_03001 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to depressive disorder via a biomarker relationship. One of these genes is associated with a study reporting a log2 fold change of approximately 1.498 and an adjusted p-value of 0.008547. Which protein doe... | IL6R | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03001","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to depres... | |
medium_hidden_intermediate_03003 | A gene is downregulated by Primate bocaparvovirus 1 and participates in Neutrophil degranulation. Experimental evidence for this gene reports a log2 fold change of -1.567 and an adjusted p-value of 0.001028. Which protein is encoded by this gene? | Bridging integrator 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03003","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and participates in Neutrophil degranulation. Experimental evidence for ... | |
medium_hidden_intermediate_03005 | Rhinovirus A upregulates a specific gene that participates in the Generic Transcription Pathway. Evidence for this gene reports a log2 fold change of approximately 1.098 and an adjusted p-value of 0.01052. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03005","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A upregulates a specific gene that participates in the Generic Transcription Pathway. Evidence for this gene repo... | |
medium_hidden_intermediate_03007 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which is subsequently found to be enriched in natural killer cells. This gene exhibits a log2 fold change of -1.355 and an adjusted p-value of 0.01264. Which biological process is this g... | cellular response to calcium ion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03007","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_03008 | Two genes are each downregulated by Vaccinia virus and associated with breast carcinoma. One of these genes exhibits a log2 fold change of approximately -1.106 and an adjusted p-value of 0.04463 in a cervical adenocarcinoma cell line study (GSE11238). Which protein interacts with this specific gene? | DCAF1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03008","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each downregulated by Vaccinia virus and associated with breast carcinoma. One of these genes exhibits a log2 ... | |
medium_hidden_intermediate_03009 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of a gene that enables growth factor activity. One such gene exhibits a log2 fold change of -1.062 and an adjusted p-value of 0.0268. Which protein is encoded by this specific gene? | Pleiotrophin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03009","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of a gene that enables... | |
medium_hidden_intermediate_03010 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes that subsequently bind to STX16. One such gene exhibited a log2 fold change of approximately 1.99 and an adjusted p-value of 4.765e-07. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03010","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes ... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.