qa_id stringlengths 24 32 | question stringlengths 156 1.14k | answer stringlengths 3 134 | level stringclasses 1
value | subtype stringclasses 3
values | source_medium_qa_id stringclasses 1
value | record_json stringlengths 13.6k 214k |
|---|---|---|---|---|---|---|
medium_hidden_intermediate_03011 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a specific gene that participates in biological oxidations. This gene exhibited a log2 fold change of 1.343 and an adjusted p-value of 2.21e-08. Which biological process is this gene involved in? | S-adenosylmethionine biosynthetic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03011","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a specific gene tha... | |
medium_hidden_intermediate_03012 | Zika virus downregulates a gene that enables nucleosome binding. In a study of glioma stem cells (GSE114907), one such gene exhibits a log2 fold change of approximately -1.60 and an adjusted p-value of approximately 0.0084. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03012","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that enables nucleosome binding. In a study of glioma stem cells (GSE114907), one such gene ... | |
medium_hidden_intermediate_03013 | A gene serves as a marker for Natural killer cells and is enriched in Memory CD8+ T cells. Evidence for this gene reports a mean expression of 68.28 TPM, a z-score of 1.51, and a fold enrichment of 3.94. Which disease is associated with this gene? | myeloid leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03013","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for Natural killer cells and is enriched in Memory CD8+ T cells. Evidence for this gene reports a ... | |
medium_hidden_intermediate_03014 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with myocardial infarction. One of these genes exhibits a log2 fold change of approximately 1.65 and an adjusted p-value of approximately 0.0089 in cardiomyocyte cell lines. Which cellular component is the location of ... | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03014","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with myocardial infarc... | |
medium_hidden_intermediate_03015 | In a study of vascular endothelial cells (GSE16354), a specific gene was found to be downregulated by Human gammaherpesvirus 8 and associated with lung cancer through genomic alterations. This gene exhibited a log2 fold change of -3.193 and an adjusted p-value of 0.009678. Which protein is encoded by this gene? | Interleukin-1 beta | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03015","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of vascular endothelial cells (GSE16354), a specific gene was found to be downregulated by Human gammaherpesvirus... | |
medium_hidden_intermediate_03019 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Fatty acid metabolism. Experimental data for this gene reports a log2 fold change of 1.368 and an adjusted p-value of 0.04515. Which disease is associated with this gene? | trophoblastic neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03019","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Fatty acid metabolism. Ex... | |
medium_hidden_intermediate_03020 | Human immunodeficiency virus 1 downregulates a gene that is located in the mitochondrial intermembrane space. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of -1.645 and an adjusted p-value of 0.0008599. Which protein is encoded by this gene? | Mitochondrial intermembrane space import and assembly protein 40 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03020","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is located in the mitochondrial intermembrane space. In a study of ... | |
medium_hidden_intermediate_03021 | Zika virus downregulates a gene that enables guanyl-nucleotide exchange factor activity. In a study of glioma stem cells (GSE114907), one such gene exhibits a log2 fold change of approximately -1.50 and an adjusted p-value of 0.034. Which protein is encoded by this specific gene? | Ankyrin repeat domain-containing protein 27 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03021","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that enables guanyl-nucleotide exchange factor activity. In a study of glioma stem cells (GS... | |
medium_hidden_intermediate_03023 | Pegivirus C is reported to downregulate a gene that is involved in the positive regulation of protein localization to the plasma membrane. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -1.217 and an adjusted p-value of 0.006056. Which protein i... | Protein canopy homolog 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03023","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in the positive regulation of protein localization to the pl... | |
medium_hidden_intermediate_03024 | Human immunodeficiency virus 1 upregulates a gene that participates in Developmental Biology. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of approximately 2.43 and an adjusted p-value of approximately 0.0065. Which disease is associated with this gene as a biomarker? | lung adenocarcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03024","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in Developmental Biology. Evidence for this gene in macr... | |
medium_hidden_intermediate_03028 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in Beta-catenin independent WNT signaling. One of these genes exhibits a log2 fold change of approximately -1.043 and an adjusted p-value of 0.04975 in lung tissue. Which biological process is this specific gene involve... | Wnt signaling pathway, planar cell polarity pathway | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03028","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in Beta-catenin indepen... | |
medium_hidden_intermediate_03029 | Hepacivirus C upregulates a gene that participates in Sensory Perception. Evidence for one such gene reports a log2 fold change of 3.442 and an adjusted p-value of 0.0226. Which protein is encoded by that gene? | Epithelial sodium channel subunit delta | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03029","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in Sensory Perception. Evidence for one such gene reports a log2 fold cha... | |
medium_hidden_intermediate_03030 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is associated with sarcoma. Experimental data for this gene reports a log2 fold change of -1.129 and an adjusted p-value of 0.0009636. In which cell type is this gene enriched? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03030","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is associated with sarcoma. Experimenta... | |
medium_hidden_intermediate_03031 | Goserelin and Pasireotide are both known to interact with a specific drug. Clinical evidence indicates that this drug, either alone or in combination with other oral antidiabetic medications, controlled elevations in glucose levels in most patients treated with Pasireotide. Which disease is this drug indicated for? | type 2 diabetes mellitus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03031","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Goserelin and Pasireotide are both known to interact with a specific drug. Clinical evidence indicates that this drug, eithe... | |
medium_hidden_intermediate_03033 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and its product interacts with UBC. Evidence for this gene reports a log2 fold change of -1.071 and an adjusted p-value of 0.01387. Which protein is encoded by this gene? | Transmembrane protein 160 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03033","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and its prod... | |
medium_hidden_intermediate_03034 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in proteolysis. Experimental data for this gene reports a log2 fold change of approximately -1.07 and an adjusted p-value of approximately 0.0039. Which disease is associated with this gene? | glioma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03034","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in proteolysis. Experimenta... | |
medium_hidden_intermediate_03035 | Two genes are each downregulated by Human betaherpesvirus 5 and associated with adenoviridae infectious disease. One of these genes exhibits a log2 fold change of -1.155 and an adjusted p-value of 0.003601 in foreskin fibroblast cell lines. Which protein does this specific gene interact with? | SSTR5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03035","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each downregulated by Human betaherpesvirus 5 and associated with adenoviridae infectious disease. One of thes... | |
medium_hidden_intermediate_03036 | Zika virus downregulates a gene that interacts with BRCA1. In a study of glioma stem cells (GSE114907), one such gene exhibits a log2 fold change of -1.474 and an adjusted p-value of 0.02685. Which protein is encoded by this gene? | FMR1-interacting protein NUFIP1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03036","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with BRCA1. In a study of glioma stem cells (GSE114907), one such gene exhibi... | |
medium_hidden_intermediate_03037 | Two genes are downregulated by Hepacivirus C and enriched in non-classical monocytes. One of these genes exhibits a log2 fold change of -1.485 and an adjusted p-value of 0.0161 in peripheral blood mononuclear cells. Which molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03037","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Hepacivirus C and enriched in non-classical monocytes. One of these genes exhibits a log2 fol... | |
medium_hidden_intermediate_03039 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by the virus and its product interacts with CDC42. This gene exhibits a log2 fold change of approximately 1.013 and an adjusted p-value of 7.055e-10. Which protein is encoded by this gene? | Band 4.1-like protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03039","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by th... | |
medium_hidden_intermediate_03040 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene that participates in phospholipid metabolism. This gene exhibited a log2 fold change of approximately 6.90 and an adjusted p-value of 2.198e-06. Which biological process is this gene involved in... | N-acylphosphatidylethanolamine metabolic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03040","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_03041 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of certain genes whose protein products are located in the endosome. One such gene exhibits a log2 fold change of 1.411 and an adjusted p-value of 0.004945. Which protein is encoded by this specific gene? | Kinesin-like protein KIF16B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03041","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of certain genes whose p... | |
medium_hidden_intermediate_03043 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus serves as a biomarker for amyloidosis. This specific gene exhibits a log2 fold change of 1.233 and an adjusted p-value of 8.781e-05. Which protein is encoded by this gene? | LIM domain kinase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03043","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus serves as a biomarker for ... | |
medium_hidden_intermediate_03044 | Zika virus downregulates a gene that enables protein phosphatase inhibitor activity. In a study of glioma stem cells (GSE114907), one such gene exhibits a log2 fold change of -1.131 and an adjusted p-value of 0.04956. Which protein is encoded by this gene? | Serine/threonine-protein phosphatase 1 regulatory subunit 10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03044","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that enables protein phosphatase inhibitor activity. In a study of glioma stem cells (GSE114... | |
medium_hidden_intermediate_03046 | Human immunodeficiency virus 1 upregulates a gene that is located in the focal adhesion. Evidence for this gene in macrophages (study GSE108897) reports a log2 fold change of approximately 1.173 and an adjusted p-value of 0.009886. Which biological process is this gene involved in? | epithelial cell differentiation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03046","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is located in the focal adhesion. Evidence for this gene in macrophag... | |
medium_hidden_intermediate_03050 | Pegivirus C is reported to downregulate a specific gene that enables mRNA 3'-UTR binding. Experimental data for this gene in peripheral blood mononuclear cells shows a log2 fold change of approximately -1.68 and an adjusted p-value of approximately 0.0166. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03050","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene that enables mRNA 3'-UTR binding. Experimental data for this gene in... | |
medium_hidden_intermediate_03052 | Hepacivirus C is reported to downregulate multiple genes that are involved in signal transduction. One such gene exhibits a log2 fold change of -1.528 and an adjusted p-value of 5.885e-05 in natural killer cells. Which disease is associated with this specific gene? | cluster headache syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03052","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate multiple genes that are involved in signal transduction. One such gene exhibits a ... | |
medium_hidden_intermediate_03053 | Zika virus downregulates a gene that participates in chromatin organization. Evidence for one such gene reports a log2 fold change of -1.117 and an adjusted p-value of 0.0176. Which disease is associated with this gene as a biomarker? | lung cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03053","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in chromatin organization. Evidence for one such gene reports a log2 fold ... | |
medium_hidden_intermediate_03054 | In a study of Influenza A virus infection, a specific gene is upregulated by the virus and enables sequence-specific DNA binding. Evidence for this gene reports a log2 fold change of 1.317 and an adjusted p-value of 1.029e-06. Which biological process is this gene involved in? | positive regulation of transcription by RNA polymerase II | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03054","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is upregulated by the virus and enables sequence-specific DNA bin... | |
medium_hidden_intermediate_03056 | Human alphaherpesvirus 1 upregulates a gene that enables histone binding. In a study of monocytic leukemia cell lines (GSE114966), one such gene showed a log2 fold change of approximately 1.33 and an adjusted p-value of 0.0037. Which protein is encoded by this gene? | Protein DEK | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03056","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that enables histone binding. In a study of monocytic leukemia cell lines (GSE11... | |
medium_hidden_intermediate_03057 | A gene is upregulated by Measles morbillivirus and is involved in the positive regulation of DNA-templated transcription. Evidence for this gene reports a log2 fold change of approximately 1.37 and an adjusted p-value of 0.011. Which disease is associated with this gene as a biomarker? | prostate carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03057","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and is involved in the positive regulation of DNA-templated transcription. Ev... | |
medium_hidden_intermediate_03058 | A gene serves as a marker for secretory cells and is enriched in neutrophils. Evidence for this gene includes a mean expression of 29.72 TPM, a z-score of 2.26, and a fold enrichment of 6.85. Which disease is associated with this gene? | metastatic melanoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03058","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for secretory cells and is enriched in neutrophils. Evidence for this gene includes a mean express... | |
medium_hidden_intermediate_03060 | GNA15 interacts with a specific protein that serves as a biomarker for depressive disorder. Research indicates that signaling through this protein and its counterpart differentially regulates depression-like behaviors. Which disease is associated with this protein via genomic alterations? | major depressive disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03060","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"GNA15 interacts with a specific protein that serves as a biomarker for depressive disorder. Research indicates that signalin... | |
medium_hidden_intermediate_03061 | A gene is upregulated by Measles morbillivirus and serves as a biomarker for ulcerative colitis. Experimental data for this gene reports a log2 fold change of approximately 1.02 and an adjusted p-value of approximately 0.004. Which protein is encoded by this gene? | N-terminal kinase-like protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03061","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and serves as a biomarker for ulcerative colitis. Experimental data for this ... | |
medium_hidden_intermediate_03063 | In a study of rhabdomyosarcoma cells infected with Enterovirus A, a specific gene is upregulated and involved in the immune response. This gene exhibits a log2 fold change of approximately 1.373 and an adjusted p-value of 0.04791. Which protein is encoded by this gene? | Interferon-induced transmembrane protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03063","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells infected with Enterovirus A, a specific gene is upregulated and involved in the immune ... | |
medium_hidden_intermediate_03066 | Zika virus downregulates a specific gene that is located in the lamellipodium. Transcriptomic data for this gene shows a log2 fold change of approximately -2.03 and an adjusted p-value of 0.0113. Which biological process is this gene involved in? | positive regulation of platelet activation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03066","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is located in the lamellipodium. Transcriptomic data for this gene shows a log... | |
medium_hidden_intermediate_03067 | Pegivirus C is reported to downregulate a gene that is associated with bone resorption disease. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibits a log2 fold change of approximately -1.144 and an adjusted p-value of 0.005531. Which protein is encoded by this specific gene? | Zinc finger protein 384 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03067","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is associated with bone resorption disease. In a study of peripheral blo... | |
medium_hidden_intermediate_03068 | Pegivirus C is reported to downregulate a specific gene, which is subsequently found to be enriched in Gamma delta (γδ) T cells. Experimental data for this gene in peripheral blood mononuclear cells (from study GSE131504) indicates a log2 fold change of approximately -1.001 and an adjusted p-value of 0.01868. Which pro... | Zinc finger protein 276 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03068","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which is subsequently found to be enriched in Gamma delta (γδ) T ce... | |
medium_hidden_intermediate_03069 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to downregulate a specific gene that participates in platelet activation, signaling, and aggregation. This gene exhibited a log2 fold change of -1.769 and an adjusted p-value of 0.02093. Which cellular component is this gene loca... | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03069","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to downregulate a specific gene t... | |
medium_hidden_intermediate_03070 | Measles morbillivirus upregulates a gene that interacts with YWHAZ. One such gene exhibits a log2 fold change of 1.133 and an adjusted p-value of 0.02885 in study GSE131840. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03070","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that interacts with YWHAZ. One such gene exhibits a log2 fold change of 1.133 and a... | |
medium_hidden_intermediate_03071 | Zaire ebolavirus upregulates a gene that binds to SOCS1. In a study of retinal pigment epithelium cells (GSE100839), one such gene showed a log2 fold change of approximately 1.94 and an adjusted p-value of approximately 0.04. Which protein is encoded by this specific gene? | Interferon alpha-10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03071","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus upregulates a gene that binds to SOCS1. In a study of retinal pigment epithelium cells (GSE100839), one suc... | |
medium_hidden_intermediate_03072 | Two genes are linked to Human immunodeficiency virus 1 via downregulation and to schizophrenia via biomarker association. One of these genes exhibits a log2 fold change of -2.114 and an adjusted p-value of 4.392e-05 in macrophages (study GSE108897). Which gene is connected to this specific entity through a binds intera... | RHOQ | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03072","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Human immunodeficiency virus 1 via downregulation and to schizophrenia via biomarker association. On... | |
medium_hidden_intermediate_03074 | Cardiovirus A downregulates a gene that enables signaling receptor activity. Evidence for this gene reports a log2 fold change of -1.702 and an adjusted p-value of 0.01801. Which cell type is this gene enriched in? | naive B cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03074","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A downregulates a gene that enables signaling receptor activity. Evidence for this gene reports a log2 fold chan... | |
medium_hidden_intermediate_03075 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Signaling by Receptor Tyrosine Kinases. Evidence for this gene reports a log2 fold change of 1.058 and an adjusted p-value of 0.0006209. Which protein is encoded by this gene? | Ras-related protein Ral-A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03075","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Signaling by Receptor Tyrosine... | |
medium_hidden_intermediate_03076 | Two genes are structurally linked to Measles morbillivirus via an upregulation relationship and to Natural killer cells via an enrichment relationship. One of these genes is associated with a study reporting a log2 fold change of approximately 1.728 and an adjusted p-value of approximately 0.032. Which protein is encod... | THAP domain-containing protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03076","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Measles morbillivirus via an upregulation relationship and to Natural killer cells via ... | |
medium_hidden_intermediate_03077 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in the regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). One of these genes exhibits a log2 fold change of approximately -3.30 and an adjusted p... | insulin-like growth factor binary complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03077","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in the regulation of In... | |
medium_hidden_intermediate_03078 | Two genes are linked to Human mastadenovirus C via upregulation and to hepatocellular carcinoma via biomarker association. One of these genes exhibits a log2 fold change of approximately 1.195 and an adjusted p-value of 0.04322 in lung fibroblast cell lines (study GSE120891). Which gene interacts with the gene identifi... | CBR3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03078","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Human mastadenovirus C via upregulation and to hepatocellular carcinoma via biomarker association. O... | |
medium_hidden_intermediate_03080 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in the Toll Like Receptor 10 (TLR10) Cascade. One such gene exhibits a log2 fold change of approximately 1.89 and an adjusted p-value of approximately 0.0011. Which protein is encoded by this specific gene? | Ribosomal protein S6 kinase alpha-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03080","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in the Toll Like ... | |
medium_hidden_intermediate_03081 | Hepacivirus C is associated with the downregulation of a gene that enables G protein-coupled receptor binding. In a study of peripheral blood mononuclear cells, this gene exhibited a log2 fold change of approximately -1.60 and an adjusted p-value of 0.017. Which protein is encoded by this gene? | Chemokine-like protein TAFA-5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03081","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is associated with the downregulation of a gene that enables G protein-coupled receptor binding. In a study of... | |
medium_hidden_intermediate_03082 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and subsequently linked to the molecular function 'phosphotyrosine residue binding' via an 'enables' relationship. One of these genes is associated with experimental data reporting a log2 fold c... | Breast cancer anti-estrogen resistance protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03082","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_03083 | Zika virus downregulates a gene that participates in rRNA processing. Evidence for one such gene reports a log2 fold change of -1.527 and an adjusted p-value of 0.003916. Which disease is associated with that gene? | mitochondrial DNA depletion syndrome 17 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03083","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in rRNA processing. Evidence for one such gene reports a log2 fold change ... | |
medium_hidden_intermediate_03084 | Human immunodeficiency virus 1 downregulates a gene that is part of the MCM complex. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of -2.277 and an adjusted p-value of 0.006537. Which protein is encoded by this specific gene? | DNA replication licensing factor MCM5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03084","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is part of the MCM complex. In a study of macrophages (GSE108897), ... | |
medium_hidden_intermediate_03086 | Hepacivirus C is associated with the downregulation of a gene involved in chemical synaptic transmission. Experimental data for this gene reports a log2 fold change of -1.153 and an adjusted p-value of 0.04912. Which protein is encoded by this gene? | Calcium-activated potassium channel subunit beta-4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03086","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is associated with the downregulation of a gene involved in chemical synaptic transmission. Experimental data ... | |
medium_hidden_intermediate_03087 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to MAPK6/MAPK4 signaling via a 'participates in' relationship. One of these genes has been reported in a study with a log2 fold change of approximately -1.899 and an adjusted p-value of 0.03... | RHOQ | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03087","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_03088 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the defense response to Gram-negative bacterium. Evidence for this gene reports a log2 fold change of 1.707 and an adjusted p-value of 0.003316. Which disease is associated with this gene as a biomarker? | systemic lupus erythematosus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03088","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the defense response to Gr... | |
medium_hidden_intermediate_03089 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the upregulation of certain host genes that subsequently interact with CUL3. One such gene exhibits a log2 fold change of approximately 2.55 and an adjusted p-value of 9.13e-09. What molecular function is enabled by this specific ... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03089","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the upregulation of certain host g... | |
medium_hidden_intermediate_03090 | In a study of glioma stem cells (GSE114907), a gene is downregulated by Zika virus and is associated with heat shock protein binding. This specific gene exhibits a log2 fold change of approximately -1.292 and an adjusted p-value of 0.03229. Which protein is encoded by this gene? | Protein N-lysine methyltransferase METTL21A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03090","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), a gene is downregulated by Zika virus and is associated with heat shock protein... | |
medium_hidden_intermediate_03092 | A gene is downregulated by Measles morbillivirus and is enriched in basophils. Experimental data for this gene reports a log2 fold change of -1.349 and an adjusted p-value of 0.00329. Which protein is encoded by this gene? | Protein NipSnap homolog 3B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03092","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Measles morbillivirus and is enriched in basophils. Experimental data for this gene reports a log... | |
medium_hidden_intermediate_03093 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with lung carcinoma. One of these genes exhibits a log2 fold change of 2.450 and an adjusted p-value of 0.009703 in a specific study. What molecular function is enabled by this gene? | serine-type endopeptidase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03093","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with lung carcinoma. O... | |
medium_hidden_intermediate_03094 | SNRNP70 interacts with a specific protein that enables protein binding. Evidence for this protein indicates that Co-immunoprecipitation, immunolocalization, and in vitro binding experiments demonstrate it is a component of the SMN complex, localizes to gems, and interacts with several Sm proteins of the spliceosomal sn... | Gem-associated protein 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03094","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"SNRNP70 interacts with a specific protein that enables protein binding. Evidence for this protein indicates that Co-immunopr... | |
medium_hidden_intermediate_03095 | Pegivirus C downregulates a gene that participates in transport to the Golgi and subsequent modification. Evidence for this gene in peripheral blood mononuclear cells (study GSE131504) reports a log2 fold change of approximately -1.598 and an adjusted p-value of 0.03447. Which cellular component is this gene located in... | endoplasmic reticulum membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03095","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that participates in transport to the Golgi and subsequent modification. Evidence for this ... | |
medium_hidden_intermediate_03096 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables signaling receptor binding. Evidence for this gene shows a log2 fold change of 2.900 and an adjusted p-value of 5.224e-16. Which protein does this gene product bind to? | TNFRSF18 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03096","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables signaling receptor binding. Evidence f... | |
medium_hidden_intermediate_03097 | Two genes are structurally linked to Measles morbillivirus via an upregulation relationship and to KIAA0753 via an interaction relationship. One of these genes is reported in a study (GSE117668) with a log2 fold change of approximately 2.203 and an adjusted p-value of 0.000223. Which cell type is this specific gene enr... | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03097","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Measles morbillivirus via an upregulation relationship and to KIAA0753 via an interacti... | |
medium_hidden_intermediate_03098 | A gene is downregulated by Pegivirus C and participates in aerobic respiration and respiratory electron transport. Experimental data for this gene in peripheral blood mononuclear cells (study GSE131504) show a log2 fold change of -1.092 and an adjusted p-value of 0.02751. Which disease is associated with this gene as a... | renal cell carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03098","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Pegivirus C and participates in aerobic respiration and respiratory electron transport. Experimen... | |
medium_hidden_intermediate_03099 | Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to lung carcinoma via an 'associated with' relationship. One of these genes exhibits a log2 fold change of approximately -2.41 and an adjusted p-value of approximately 0.029 in a specific study context. Which cell... | CD4-positive, alpha-beta memory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03099","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to lung carcinoma... | |
medium_hidden_intermediate_03101 | Human betaherpesvirus 5 upregulates a gene that binds to NCOA3. One such gene exhibits a log2 fold change of 1.043 and an adjusted p-value of 0.02647 in dendritic cells. Which disease is associated with this specific gene? | allergic asthma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03101","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that binds to NCOA3. One such gene exhibits a log2 fold change of 1.043 and an ad... | |
medium_hidden_intermediate_03103 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, the product of which is located in the midbody. This gene exhibited a log2 fold change of approximately -1.64 and an adjusted p-value of 0.00213. Which protein is encoded by this gene? | Septin-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03103","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, the product... | |
medium_hidden_intermediate_03104 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is located in the extracellular matrix. Evidence for this gene reports a log2 fold change of 3.103 and an adjusted p-value of 0.01442. Which disease is associated with this gene? | leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03104","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is located in the extracellular matrix. E... | |
medium_hidden_intermediate_03105 | Two genes are upregulated by Vaccinia virus and interact with KIAA0753. One of these genes exhibits a log2 fold change of 1.528 and an adjusted p-value of 7.372e-05 in cervical adenocarcinoma cell lines. Which disease is associated with this specific gene as a biomarker? | chorioamnionitis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03105","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and interact with KIAA0753. One of these genes exhibits a log2 fold change of 1.... | |
medium_hidden_intermediate_03106 | Two genes are structurally linked from Measles morbillivirus to glioma via upregulation and biomarker associations. One of these genes has an associated study reporting a log2 fold change of approximately 1.118 and an adjusted p-value of 0.0006251. Which protein is encoded by the gene matching these statistical values? | Leucine-rich repeats and immunoglobulin-like domains protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03106","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Measles morbillivirus to glioma via upregulation and biomarker associations. One of t... | |
medium_hidden_intermediate_03107 | Zika virus downregulates a gene that is located in the trans-Golgi network. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -1.875 and an adjusted p-value of 0.002997. Which cell type is this gene enriched in? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03107","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in the trans-Golgi network. Experimental data for this gene in glioma stem c... | |
medium_hidden_intermediate_03108 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is located in the recycling endosome membrane. Evidence for this gene reports a log2 fold change of -1.228 and an adjusted p-value of 0.0304. Which protein is encoded by this gene? | CAP-Gly domain-containing linker protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03108","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is located in the recycling endosome membran... | |
medium_hidden_intermediate_03109 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and its product is located in the Golgi membrane. Experimental data for this gene reports a log2 fold change of approximately 1.12 and an adjusted p-value of 0.037. Which protein is encoded by this gene? | Adenosine 3'-phospho 5'-phosphosulfate transporter 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03109","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and its product is located in the Golgi membr... | |
medium_hidden_intermediate_03110 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in turn binds to RPL37. This gene exhibited a log2 fold change of -1.318 and an adjusted p-value of 0.002221. Which protein is encoded by this gene? | Eukaryotic peptide chain release factor subunit 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03110","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in tu... | |
medium_hidden_intermediate_03111 | Measles morbillivirus upregulates a gene that is located in the cytosol. Evidence for one such gene reports a log2 fold change of 1.674 and an adjusted p-value of 0.01838. Which disease is associated with that gene? | colitis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03111","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is located in the cytosol. Evidence for one such gene reports a log2 fold chan... | |
medium_hidden_intermediate_03112 | Head and Neck Neoplasms are localized to a specific anatomical structure that is classified as a tube. Evidence describes this structure as 'The paired channels leading from the lacrimal sacs to the inferior meatus of the nose, through which tears are conducted through the nasal cavity.' Which anatomical system is this... | lacrimal drainage system | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03112","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Head and Neck Neoplasms are localized to a specific anatomical structure that is classified as a tube. Evidence describes th... | |
medium_hidden_intermediate_03113 | In a study of pleural mesothelioma cells (GSE117668), a gene is identified that is upregulated by Measles morbillivirus and participates in Aspirin ADME. This specific gene exhibits a log2 fold change of 1.339 and an adjusted p-value of 0.002113. What molecular function is enabled by this gene? | glutamine N-acyltransferase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03113","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), a gene is identified that is upregulated by Measles morbillivirus and ... | |
medium_hidden_intermediate_03114 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and its product interacts with CDC42. Evidence for this gene reports a log2 fold change of 1.172 and an adjusted p-value of 0.01021. Which protein is encoded by this gene? | SH3 domain-containing protein 19 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03114","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and its produc... | |
medium_hidden_intermediate_03115 | In a study of peripheral blood mononuclear cells (GSE131504), a gene is downregulated by Pegivirus C and interacts with TP53. This gene exhibits a log2 fold change of -1.665 and an adjusted p-value of 0.01232. Which protein is encoded by this gene? | Homeodomain-interacting protein kinase 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03115","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of peripheral blood mononuclear cells (GSE131504), a gene is downregulated by Pegivirus C and interacts with TP53... | |
medium_hidden_intermediate_03118 | Human immunodeficiency virus 1 upregulates a gene that is located in the centrosome. Evidence for this specific gene in macrophages (from study GSE108897) reports a log2 fold change of 1.163 and an adjusted p-value of 0.01502. Which biological process is this gene involved in? | regulation of cilium assembly | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03118","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is located in the centrosome. Evidence for this specific gene in macr... | |
medium_hidden_intermediate_03119 | Two genes are upregulated by Vaccinia virus and participate in chromatin modifying enzyme activity. One of these genes exhibits a log2 fold change of approximately 1.537 and an adjusted p-value of 2.644e-06 in a cervical adenocarcinoma cell line study. Which disease is associated with this specific gene? | non-small cell lung carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03119","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and participate in chromatin modifying enzyme activity. One of these genes exhib... | |
medium_hidden_intermediate_03123 | Two genes are structurally linked from Severe acute respiratory syndrome-related coronavirus to endometriosis via a path involving downregulation by the virus and association with the disease. One of these genes is reported in a study (GSE153218) using SAEC cells, showing a log2 fold change of approximately -1.378 and ... | Sphingosine-1-phosphate lyase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03123","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Severe acute respiratory syndrome-related coronavirus to endometriosis via a path inv... | |
medium_hidden_intermediate_03125 | Human immunodeficiency virus 1 upregulates a gene that is involved in protein ubiquitination. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately 4.49 and an adjusted p-value of 3.35e-05. Which protein is encoded by this gene? | E3 ISG15--protein ligase HERC5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03125","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is involved in protein ubiquitination. In a study of macrophages (GSE... | |
medium_hidden_intermediate_03126 | A gene is downregulated by Human gammaherpesvirus 8 and participates in GPCR downstream signalling. Experimental data for this gene in vascular endothelial cells (study GSE16354) reports a log2 fold change of -3.271 and an adjusted p-value of 0.0004332. Which cell type is this gene enriched in? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03126","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Human gammaherpesvirus 8 and participates in GPCR downstream signalling. Experimental data for th... | |
medium_hidden_intermediate_03129 | Two genes are downregulated by Human immunodeficiency virus 1 and participate in the RHOA GTPase cycle. One of these genes exhibits a log2 fold change of -1.088 and an adjusted p-value of 4.093e-05 in a specific study. Which cell type is enriched for this specific gene? | non-classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03129","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Human immunodeficiency virus 1 and participate in the RHOA GTPase cycle. One of these genes e... | |
medium_hidden_intermediate_03130 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by the virus and participates in the immune system. This gene exhibits a log2 fold change of 2.739 and an adjusted p-value of 0.02872. Which protein is encoded by this gene? | Interstitial collagenase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03130","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by th... | |
medium_hidden_intermediate_03133 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in infectious disease. Evidence for one such gene reports a log2 fold change of -1.654 and an adjusted p-value of 0.03107. Which protein is encoded by that gene? | Palmitoyltransferase ZDHHC2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03133","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in infectious disease. Evidence... | |
medium_hidden_intermediate_03136 | Two distinct genes form a binding bridge between EVPL and SPRR1A. One of these intermediate genes is characterized by an N-terminal domain that interacts with the plasma membrane, heterodimerization with envoplakin via its rod domain, and a C-terminus that interacts with intermediate filaments. Which disease is associa... | Glycogen storage disease, type V | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03136","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct genes form a binding bridge between EVPL and SPRR1A. One of these intermediate genes is characterized by an N-t... | |
medium_hidden_intermediate_03138 | Human betaherpesvirus 5 upregulates a gene that participates in the Adaptive Immune System. Evidence for this gene reports a log2 fold change of 2.364 and an adjusted p-value of 0.003384. Which cell type is this gene enriched in? | mucosal-associated invariant T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03138","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that participates in the Adaptive Immune System. Evidence for this gene reports a... | |
medium_hidden_intermediate_03140 | Human alphaherpesvirus 3 is known to upregulate a specific gene that enables identical protein binding. In a study of melanoma cell lines (GSE136586), this gene exhibited a log2 fold change of approximately 1.397 and an adjusted p-value of 6.18e-10. Which disease is associated with genomic alterations in this gene? | ovarian cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03140","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 is known to upregulate a specific gene that enables identical protein binding. In a study of melano... | |
medium_hidden_intermediate_03141 | Human immunodeficiency virus 1 upregulates a gene that is enriched in memory B cells. Evidence for this gene in natural killer cells from study GSE125686 reports a log2 fold change of approximately 1.337 and an adjusted p-value of approximately 0.0237. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03141","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is enriched in memory B cells. Evidence for this gene in natural kill... | |
medium_hidden_intermediate_03142 | Two genes are upregulated by Human alphaherpesvirus 3 and are enriched in neutrophils. One of these genes exhibits a log2 fold change of 1.028 and an adjusted p-value of 9.119e-07 in a melanoma cell line study (GSE136586). Which biological process is this specific gene involved in? | negative regulation of transcription by RNA polymerase II | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03142","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human alphaherpesvirus 3 and are enriched in neutrophils. One of these genes exhibits a log2 fo... | |
medium_hidden_intermediate_03145 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, two genes are upregulated and involved in the defense response to virus. One of these genes exhibits a log2 fold change of approximately 1.467 and an adjusted p-value of 0.02378. What molecular function is enabled by this spec... | RNA nuclease activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03145","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, two genes are upregulated and ... | |
medium_hidden_intermediate_03146 | Hepacivirus C is associated with the upregulation of a specific gene, which is subsequently found to be enriched in peripheral blood mononuclear cells (PBMCs). Experimental data for this gene indicates a log2 fold change of approximately 2.58 and an adjusted p-value of 2.75e-05. In which cellular component is this gene... | azurophil granule | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03146","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is associated with the upregulation of a specific gene, which is subsequently found to be enriched in peripher... | |
medium_hidden_intermediate_03148 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene that participates in antigen processing via ubiquitination and proteasome degradation. This specific gene exhibited a log2 fold change of approximately 1.196 and an adjusted p-value of 0.0005702. Which c... | anaphase-promoting complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03148","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene that pa... | |
medium_hidden_intermediate_03149 | Pegivirus C is reported to downregulate a specific gene, which in turn interacts with TP53. Experimental data for this intermediate gene in peripheral blood mononuclear cells (from study GSE131504) shows a log2 fold change of approximately -1.14 and an adjusted p-value of 0.0021. Which disease is therapeutically linked... | leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03149","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn interacts with TP53. Experimental data for this inter... | |
medium_hidden_intermediate_03151 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 is reported to downregulate a specific gene, which is involved in the negative regulation of transcription by RNA polymerase II. This gene exhibits a log2 fold change of approximately -1.21 and an adjusted p-value of approximately 0.0045. Which prote... | Max-like protein X | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03151","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 is reported to downregulate a specific gene, which is ... | |
medium_hidden_intermediate_03152 | PRKN is linked to a protein that enables calcium ion binding. Evidence indicates that Parkin interacts with a mitochondrial Rho GTPase prior to mitochondrial damage. Which protein is encoded by the gene corresponding to this interacting partner? | Mitochondrial Rho GTPase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03152","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"PRKN is linked to a protein that enables calcium ion binding. Evidence indicates that Parkin interacts with a mitochondrial ... | |
medium_hidden_intermediate_03154 | YBX1 interacts with a protein that enables ubiquitin protein ligase activity. Evidence indicates that this protein mechanistically targets Keap1 by ubiquitination and degradation. Which protein is encoded by the gene corresponding to this entity? | E3 ubiquitin/ISG15 ligase TRIM25 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03154","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"YBX1 interacts with a protein that enables ubiquitin protein ligase activity. Evidence indicates that this protein mechanist... | |
medium_hidden_intermediate_03155 | In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene upregulated by Human gammaherpesvirus 8 and participating in Metabolism was found to have a log2 fold change of approximately 1.099 and an adjusted p-value of 0.03999. Which biological process is this specific gene involved in? | N-acylethanolamine metabolic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03155","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene upregulated by Human gammaherpesvirus 8 and participating ... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.