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medium_hidden_intermediate_03157 | Hepacivirus C downregulates a specific gene that is involved in the positive regulation of gene expression. Experimental data for this gene in natural killer cells (from study GSE125686) reports a log2 fold change of approximately -1.01 and an adjusted p-value of 0.001266. Which cellular component is this gene located ... | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03157","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a specific gene that is involved in the positive regulation of gene expression. Experimental dat... | |
medium_hidden_intermediate_03159 | Human polyomavirus 1 upregulates a gene that is located in the nucleus. Experimental data from renal epithelial cells (study GSE135833) indicate that this specific gene has a log2 fold change of approximately 1.399 and an adjusted p-value of approximately 0.020. Which protein interacts with this gene product? | BTRC | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03159","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human polyomavirus 1 upregulates a gene that is located in the nucleus. Experimental data from renal epithelial cells (study... | |
medium_hidden_intermediate_03166 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate specific genes that enable DNA-binding transcription activator activity, RNA polymerase II-specific. One such gene exhibited a log2 fold change of -2.154 and an adjusted p-value of 0.03822. Which protein does... | ZBTB2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03166","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate specific gen... | |
medium_hidden_intermediate_03167 | Measles morbillivirus upregulates a gene that participates in rRNA processing. Evidence for one such gene reports a log2 fold change of 1.069 and an adjusted p-value of 0.01594. Which protein is encoded by that gene? | Polynucleotide 5'-hydroxyl-kinase NOL9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03167","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that participates in rRNA processing. Evidence for one such gene reports a log2 fol... | |
medium_hidden_intermediate_03168 | In a study of glioma stem cells (GSE114907), Zika virus infection leads to the downregulation of a specific gene, which in turn interacts with RUVBL1. This gene exhibits a log2 fold change of -2.174 and an adjusted p-value of 0.002827. Which protein is encoded by this gene? | Protein AAR2 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03168","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), Zika virus infection leads to the downregulation of a specific gene, which in t... | |
medium_hidden_intermediate_03170 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a specific gene that participates in Signaling by Rho GTPases. This gene exhibited a log2 fold change of approximately 3.11 and an adjusted p-value of 9.42e-10. Which protein is encoded by this gene? | Serine/threonine-protein kinase N3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03170","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a specific gene tha... | |
medium_hidden_intermediate_03171 | Pegivirus C downregulates a gene that enables cysteine-type peptidase activity. In a study of peripheral blood mononuclear cells (GSE131504), one such gene showed a log2 fold change of approximately -1.26 and an adjusted p-value of 0.038. Which cellular component is this gene located in? | NLRP1 inflammasome complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03171","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that enables cysteine-type peptidase activity. In a study of peripheral blood mononuclear c... | |
medium_hidden_intermediate_03173 | A gene serves as a marker for B cells and is enriched in eosinophils. Expression data for this gene indicates a mean expression of 55.02 TPM, a z-score of 1.87, and a fold enrichment of 3.91. Which disease is associated with this gene as a biomarker? | colon carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03173","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for B cells and is enriched in eosinophils. Expression data for this gene indicates a mean express... | |
medium_hidden_intermediate_03174 | Zika virus infection leads to the downregulation of a specific gene, which is subsequently found to be enriched in naive CD4+ T cells. Transcriptomic data from glioma stem cells (study GSE114907) indicates that this gene has a log2 fold change of -1.460 and an adjusted p-value of 0.02107. Which protein is encoded by th... | Inositol-trisphosphate 3-kinase B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03174","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection leads to the downregulation of a specific gene, which is subsequently found to be enriched in naive CD4... | |
medium_hidden_intermediate_03175 | In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and is associated with melanoma. Evidence for this gene reports a log2 fold change of 1.210 and an adjusted p-value of 0.03531. Which protein is encoded by this gene? | Ribonuclease SLFN12 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03175","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and is associated with melanoma. ... | |
medium_hidden_intermediate_03176 | Hepacivirus C is reported to downregulate a specific gene, which is in turn associated with prostate cancer. Experimental data for this gene in hepatocytes (from study GSE132606) indicate a log2 fold change of approximately -1.56 and an adjusted p-value of 0.029. Which protein is encoded by this gene? | Popeye domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03176","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a specific gene, which is in turn associated with prostate cancer. Experimental da... | |
medium_hidden_intermediate_03179 | A gene is upregulated by Primate bocaparvovirus 1 and participates in SLC-mediated transmembrane transport. Evidence for this gene reports a log2 fold change of 1.410 and an adjusted p-value of 0.02848. Which protein is encoded by this gene? | Neutral amino acid uniporter 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03179","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and participates in SLC-mediated transmembrane transport. Evidence for thi... | |
medium_hidden_intermediate_03180 | Hepacivirus C is reported to upregulate a gene that participates in RNA Polymerase II transcription. Evidence for one such gene indicates a log2 fold change of 1.345 and an adjusted p-value of 0.04543. Which protein is encoded by this gene? | Zinc finger protein 770 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03180","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to upregulate a gene that participates in RNA Polymerase II transcription. Evidence for one such g... | |
medium_hidden_intermediate_03181 | Human betaherpesvirus 5 upregulates a gene that participates in Signaling by Nuclear Receptors. Evidence for this gene in foreskin fibroblast cell lines reports a log2 fold change of approximately 1.434 and an adjusted p-value of approximately 0.0459. Which protein is encoded by this gene? | Nuclear receptor subfamily 5 group A member 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03181","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that participates in Signaling by Nuclear Receptors. Evidence for this gene in fo... | |
medium_hidden_intermediate_03184 | In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upregulate a specific gene, which in turn interacts with STAU1. This gene exhibited a log2 fold change of approximately 1.069 and an adjusted p-value of 0.006421. Which protein is encoded by this gene? | ATP-dependent RNA helicase DDX55 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03184","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upreg... | |
medium_hidden_intermediate_03185 | Zika virus downregulates a gene that participates in COPII-mediated vesicle transport. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of approximately -1.35 and an adjusted p-value of approximately 0.035. Which biological process is this specific gene involved in? | positive regulation of focal adhesion assembly | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03185","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in COPII-mediated vesicle transport. In a study of glioma stem cells (GSE1... | |
medium_hidden_intermediate_03187 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which in turn interacts with RPA1. The expression data for this intermediate gene shows a log2 fold change of approximately -1.512 and an adjusted p-value of 0.01819. Which protein is en... | Ewing's tumor-associated antigen 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03187","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_03188 | Two genes are downregulated by Cardiovirus A and participate in post-translational protein modification. One of these genes exhibits a log2 fold change of -1.812 and an adjusted p-value of 0.0119 in cervical adenocarcinoma cell lines. Which cell type is enriched for the expression of this specific gene? | mucosal-associated invariant T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03188","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Cardiovirus A and participate in post-translational protein modification. One of these genes ... | |
medium_hidden_intermediate_03189 | Two genes are upregulated by Human alphaherpesvirus 1 and are enriched in Natural killer cells. One of these genes has a reported log2 fold change of 1.417 and an adjusted p-value of 0.01557 in a monocytic leukemia cell line study. Which protein does this specific gene interact with? | PPP2CA | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03189","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human alphaherpesvirus 1 and are enriched in Natural killer cells. One of these genes has a rep... | |
medium_hidden_intermediate_03191 | Two genes are upregulated by Vaccinia virus and bind to POLR2K. One of these genes exhibits a log2 fold change of 2.818 and an adjusted p-value of 1.46e-06 in cervical adenocarcinoma cell lines. Which cell type is enriched for this specific gene? | mucosal-associated invariant T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03191","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and bind to POLR2K. One of these genes exhibits a log2 fold change of 2.818 and ... | |
medium_hidden_intermediate_03192 | In a study of macrophages (GSE108897), a gene is identified as being downregulated by Human immunodeficiency virus 1 and serving as a biomarker for schizophrenia. This specific gene exhibits a log2 fold change of approximately -1.059 and an adjusted p-value of 0.01127. Which protein is encoded by this gene? | Delayed-rectifier potassium channel regulatory subunit KCNS3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03192","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified as being downregulated by Human immunodeficiency virus 1 and ser... | |
medium_hidden_intermediate_03194 | Severe acute respiratory syndrome-related coronavirus upregulates multiple genes that are located in the phagocytic vesicle. One such gene exhibits a log2 fold change of 1.099 and an adjusted p-value of 1.244e-05. Which protein is encoded by this specific gene? | Syntaxin-12 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03194","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates multiple genes that are located in the phagocytic vesicle.... | |
medium_hidden_intermediate_03196 | Human immunodeficiency virus 1 downregulates a gene that participates in DNA replication. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of -1.646 and an adjusted p-value of 0.01469. Which protein is encoded by this gene? | DNA replication complex GINS protein PSF3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03196","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in DNA replication. In a study of macrophages (GSE1088... | |
medium_hidden_intermediate_03198 | A gene is downregulated by Human immunodeficiency virus 1 and participates in protein localization. Evidence for this gene reports a log2 fold change of approximately -1.24 and an adjusted p-value of approximately 0.0109. Which cell type is this gene enriched in? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03198","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Human immunodeficiency virus 1 and participates in protein localization. Evidence for this gene r... | |
medium_hidden_intermediate_03199 | Two genes are structurally linked to Human betaherpesvirus 5 via a 'downregulates' relationship and to RHOA via a 'binds' relationship. One of these genes has an associated expression profile showing a log2 fold change of approximately -1.70 and an adjusted p-value of approximately 0.041. Which cell type is this specif... | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03199","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human betaherpesvirus 5 via a 'downregulates' relationship and to RHOA via a 'binds' re... | |
medium_hidden_intermediate_03201 | A gene is downregulated by Vaccinia virus and located in the extracellular space. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately -1.76 and an adjusted p-value of approximately 0.014. Which disease is associated with this gene? | ovarian neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03201","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Vaccinia virus and located in the extracellular space. Experimental data for this gene in a cervi... | |
medium_hidden_intermediate_03205 | A gene is downregulated by Primate bocaparvovirus 1 and is involved in the regulation of the cell cycle. Experimental evidence for this gene reports a log2 fold change of -2.428 and an adjusted p-value of 0.03974. Which protein is encoded by this gene? | Cyclin-dependent kinase inhibitor 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03205","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and is involved in the regulation of the cell cycle. Experimental eviden... | |
medium_hidden_intermediate_03206 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to schizophrenia via biomarker association. One of these genes exhibits a log2 fold change of 1.040 and an adjusted p-value of 0.03944 in sclera tissue (study GSE164073). What molecular function is enabled by this specifi... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03206","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to schizophrenia via biom... | |
medium_hidden_intermediate_03207 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate multiple genes involved in aerobic respiration and respiratory electron transport. One such gene exhibited a log2 fold change of 2.796 and an adjusted p-value of 1.425e-12. Which protein is encoded by this specific ... | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03207","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate multiple genes invo... | |
medium_hidden_intermediate_03208 | ESR1 interacts with a nuclear-localized protein. Evidence indicates that XBP-1S and XBP-1U bind to ERalpha both in vitro and in vivo in a ligand-independent manner. Which disease is associated with genomic alterations in this specific protein? | metabolic dysfunction-associated steatotic liver disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03208","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"ESR1 interacts with a nuclear-localized protein. Evidence indicates that XBP-1S and XBP-1U bind to ERalpha both in vitro and... | |
medium_hidden_intermediate_03209 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A downregulates a specific gene, which in turn enables identical protein binding. This gene exhibits a log2 fold change of approximately -1.12 and an adjusted p-value of 0.0093. Which protein does this gene bind to? | SOX10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03209","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A downregulates a specific gene, which in turn ena... | |
medium_hidden_intermediate_03211 | Zika virus downregulates a gene that binds to RPA3. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.255 and an adjusted p-value of approximately 0.018. Which cell type is this gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03211","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that binds to RPA3. Experimental data for this gene in glioma stem cells (study GSE114907) r... | |
medium_hidden_intermediate_03213 | Hepacivirus C upregulates a gene that participates in the biological process 'Antigen processing: Ubiquitination & Proteasome degradation'. Evidence for one such gene reports a log2 fold change of 1.646 and an adjusted p-value of 0.0001105. Which protein is encoded by that gene? | Ankyrin repeat and SOCS box protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03213","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in the biological process 'Antigen processing: Ubiquitination & Proteasom... | |
medium_hidden_intermediate_03216 | Zika virus upregulates a gene that interacts with RAC1. Experimental data for one such gene reports a log2 fold change of approximately 1.14 and an adjusted p-value of approximately 0.048. Which protein is encoded by this gene? | E3 ubiquitin-protein ligase SH3RF3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03216","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that interacts with RAC1. Experimental data for one such gene reports a log2 fold change of ap... | |
medium_hidden_intermediate_03217 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are located in lipid droplets. One of these genes was reported in a study (GSE153218) using SAEC cells, showing a log2 fold change of approximately 1.044 and an adjusted p-value of 0.01994. Which disease is associated with this speci... | glycosylphosphatidylinositol biosynthesis defect 25 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03217","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are located in lipid droplets. One of... | |
medium_hidden_intermediate_03218 | A gene is downregulated by Measles morbillivirus and is enriched in Naive CD8+ T cells. Experimental data for this gene reports a log2 fold change of -1.109 and an adjusted p-value of 0.01733. Which protein is encoded by this gene? | Mesoderm-specific transcript homolog protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03218","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Measles morbillivirus and is enriched in Naive CD8+ T cells. Experimental data for this gene repo... | |
medium_hidden_intermediate_03219 | Two genes are known to interact with KRAS and are both enriched in natural killer cells. One of these genes exhibits a mean expression of 30.15 TPM, a z-score of 2.15, and a fold enrichment of 2.80 in immune cell RNA-seq data. Which disease is associated with this specific gene? | urinary bladder carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03219","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are known to interact with KRAS and are both enriched in natural killer cells. One of these genes exhibits a mean ... | |
medium_hidden_intermediate_03221 | Two genes are upregulated by Influenza A virus and enriched in classical monocytes. One of these genes was reported in a study (GSE147507) with a log2 fold change of 1.085 and an adjusted p-value of 1.954e-05. Which disease is associated with this specific gene as a biomarker? | psoriasis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03221","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Influenza A virus and enriched in classical monocytes. One of these genes was reported in a stu... | |
medium_hidden_intermediate_03222 | Human immunodeficiency virus 1 upregulates a gene that is associated with carcinoma. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately 5.85 and an adjusted p-value of approximately 0.000586. Which protein is encoded by this gene? | Tumor necrosis factor ligand superfamily member 9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03222","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is associated with carcinoma. In a study of macrophages (GSE108897), ... | |
medium_hidden_intermediate_03223 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is associated with colon carcinoma. Experimental data for this gene reports a log2 fold change of -1.500 and an adjusted p-value of 0.04328. Which protein is encoded by this gene? | DEP domain-containing protein 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03223","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is associated with colon carcinoma. Exp... | |
medium_hidden_intermediate_03225 | Hepacivirus C downregulates a gene that enables ATP binding. Experimental data for this gene shows a log2 fold change of approximately -1.095 and an adjusted p-value of 1.915e-05. Which cellular component is this gene located in? | mitochondrion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03225","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a gene that enables ATP binding. Experimental data for this gene shows a log2 fold change of app... | |
medium_hidden_intermediate_03228 | Hepacivirus C upregulates a gene that is involved in the response to zinc ion. Evidence for one such gene reports a log2 fold change of 3.261 and an adjusted p-value of 2.005e-06. Which protein is encoded by that gene? | Ligand-gated cation channel ZACN | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03228","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in the response to zinc ion. Evidence for one such gene reports a log2 fol... | |
medium_hidden_intermediate_03229 | Human polyomavirus 1 upregulates a gene that enables protein binding. In a study of renal epithelial cells (GSE135833), this gene showed a log2 fold change of approximately 2.83 and an adjusted p-value of 0.00258. Which protein is encoded by this gene? | Platelet-activating factor acetylhydrolase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03229","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human polyomavirus 1 upregulates a gene that enables protein binding. In a study of renal epithelial cells (GSE135833), this... | |
medium_hidden_intermediate_03230 | Human betaherpesvirus 5 is reported to downregulate a specific gene, which is in turn enriched in natural killer cells. Experimental data for this gene in foreskin fibroblast cell lines indicates a log2 fold change of approximately -1.087 and an adjusted p-value of 0.047. Which protein is encoded by this gene? | COX assembly mitochondrial protein homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03230","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a specific gene, which is in turn enriched in natural killer cells. Expe... | |
medium_hidden_intermediate_03231 | Pegivirus C is reported to downregulate a specific gene, which in turn interacts with VPS35. Transcriptomic data for this intermediate gene in peripheral blood mononuclear cells (study GSE131504) shows a log2 fold change of -1.788 and an adjusted p-value of 0.0001853. Which cellular component is this intermediate gene ... | lysosomal membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03231","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn interacts with VPS35. Transcriptomic data for this in... | |
medium_hidden_intermediate_03235 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in the positive regulation of the canonical Wnt signaling pathway. Evidence for one such gene reports a log2 fold change of -2.215 and an adjusted p-value of 0.04567. Which protein is encoded by that gene? | Dapper homolog 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03235","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in the positive regulation of th... | |
medium_hidden_intermediate_03236 | In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and located in the lysosomal membrane. This specific gene exhibits a log2 fold change of approximately -1.724 and an adjusted p-value of 0.02396. Which biological process is this gene involved in? | vacuolar transmembrane transport | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03236","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and loca... | |
medium_hidden_intermediate_03237 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the upregulation of certain host genes that subsequently bind to UTP6. One such gene exhibits a log2 fold change of approximately 1.03 and an adjusted p-value of 6.46e-05. In which cellular component is this specific gene product ... | nucleoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03237","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the upregulation of certain host g... | |
medium_hidden_intermediate_03238 | Hepacivirus C upregulates a gene that is involved in the positive regulation of transcription by RNA polymerase II. Experimental data from hepatocytes (study GSE132606) indicates that one such gene exhibits a log2 fold change of 1.622 and an adjusted p-value of 0.002346. Which protein is encoded by this specific gene? | NF-kappa-B-repressing factor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03238","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in the positive regulation of transcription by RNA polymerase II. Experime... | |
medium_hidden_intermediate_03240 | Hepacivirus C upregulates a gene that is involved in the cell surface receptor signaling pathway. Evidence for this gene in natural killer cells (study GSE125686) reports a log2 fold change of approximately 2.27 and an adjusted p-value of 0.0118. Which protein is encoded by this gene? | Platelet glycoprotein Ib beta chain | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03240","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in the cell surface receptor signaling pathway. Evidence for this gene in ... | |
medium_hidden_intermediate_03241 | Zika virus upregulates a specific gene that is involved in the response to endoplasmic reticulum stress. Experimental data for this gene shows a log2 fold change of approximately 1.44 and an adjusted p-value of 0.029. Which disease is associated with this gene? | leukodystrophy, hypomyelinating, 14 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03241","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a specific gene that is involved in the response to endoplasmic reticulum stress. Experimental data f... | |
medium_hidden_intermediate_03242 | Pegivirus C is reported to downregulate a gene that is involved in mitotic spindle assembly. In a study of peripheral blood mononuclear cells (GSE131504), one such gene showed a log2 fold change of approximately -1.175 and an adjusted p-value of 0.003453. Which protein is encoded by this specific gene? | Centrosomal protein CCDC61 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03242","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in mitotic spindle assembly. In a study of peripheral blood ... | |
medium_hidden_intermediate_03244 | A gene is upregulated by Primate bocaparvovirus 1 and participates in the Generic Transcription Pathway. Experimental evidence for this gene reports a log2 fold change of approximately 1.066 and an adjusted p-value of 0.004944. Which protein is encoded by this gene? | Zinc finger protein 706 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03244","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and participates in the Generic Transcription Pathway. Experimental eviden... | |
medium_hidden_intermediate_03245 | Two genes are structurally linked to Vaccinia virus via a downregulation relationship and to squamous cell carcinoma via an association relationship. One of these genes exhibits a log2 fold change of -1.539 and an adjusted p-value of 2.775e-08 in a specific study. Which protein is encoded by the gene matching these sta... | Forkhead box protein N3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03245","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Vaccinia virus via a downregulation relationship and to squamous cell carcinoma via an ... | |
medium_hidden_intermediate_03247 | In a study of Measles morbillivirus infection, two genes are identified as being upregulated by the virus and interacting with the PARK2 protein. One of these genes exhibits a log2 fold change of approximately 1.695 and an adjusted p-value of 0.0008589. Which protein is encoded by this specific gene? | AP-1 complex subunit gamma-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03247","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, two genes are identified as being upregulated by the virus and interacting wi... | |
medium_hidden_intermediate_03248 | In a study of natural killer cells (GSE125686), Human immunodeficiency virus 1 upregulates a gene that subsequently binds to POLR2L. One such gene exhibits a log2 fold change of 1.630 and an adjusted p-value of 0.0417. Which protein is encoded by this specific gene? | Integrator complex subunit 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03248","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of natural killer cells (GSE125686), Human immunodeficiency virus 1 upregulates a gene that subsequently binds to... | |
medium_hidden_intermediate_03250 | Human betaherpesvirus 5 is reported to downregulate a gene that subsequently binds to COX7C. In a study of foreskin fibroblast cell lines (GSE111036), one such intermediate gene exhibits a log2 fold change of approximately -1.105 and an adjusted p-value of 0.04666. Which protein is encoded by this specific gene? | Cytochrome c oxidase assembly factor 1 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03250","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that subsequently binds to COX7C. In a study of foreskin fibrobla... | |
medium_hidden_intermediate_03251 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated by the virus and its product enables signaling receptor binding. Evidence for this gene reports a log2 fold change of -2.151 and an adjusted p-value of 0.00162. Which protein is encoded by this gene? | Fractalkine | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03251","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated by the virus... | |
medium_hidden_intermediate_03252 | Enterovirus A upregulates a gene that participates in the Adaptive Immune System. In a study of rhabdomyosarcoma cells (GSE103308), one such gene showed a log2 fold change of 1.677 and an adjusted p-value of 0.009343. Which protein is encoded by this gene? | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03252","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A upregulates a gene that participates in the Adaptive Immune System. In a study of rhabdomyosarcoma cells (GSE1... | |
medium_hidden_intermediate_03253 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a downregulation relationship and to lung cancer via a biomarker relationship. One of these genes is reported in a study (GSE151803) using a pancreatic cell line, with a log2 fold change of -1.722 and an adjusted p-value of 0... | hydrocephalus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03253","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a downregulation relationship... | |
medium_hidden_intermediate_03254 | Human betaherpesvirus 5 is known to downregulate certain genes that enable heparin binding. One such gene exhibits a log2 fold change of -2.691 and an adjusted p-value of 2.029e-06 in experimental data. Which cell type is this specific gene enriched in? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03254","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is known to downregulate certain genes that enable heparin binding. One such gene exhibits a log2 fo... | |
medium_hidden_intermediate_03255 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of certain genes located in the nuclear envelope. One such gene exhibits a log2 fold change of -1.658 and an adjusted p-value of 0.01491. Which protein is encoded by this specific gene? | 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03255","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of certain... | |
medium_hidden_intermediate_03256 | In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and is involved in the apoptotic process. This gene exhibits a log2 fold change of approximately 1.367 and an adjusted p-value of 0.04798. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03256","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and is involved in the apoptotic ... | |
medium_hidden_intermediate_03257 | A gene is upregulated by Measles morbillivirus and serves as a biomarker for endometrial cancer. Evidence for this gene reports a log2 fold change of approximately 1.154 and an adjusted p-value of 0.03992. Which protein is encoded by this gene? | Eukaryotic translation initiation factor 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03257","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and serves as a biomarker for endometrial cancer. Evidence for this gene repo... | |
medium_hidden_intermediate_03258 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Glycosaminoglycan metabolism. Experimental data for this gene reports a log2 fold change of 1.438 and an adjusted p-value of 0.03826. Which cell type is this gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03258","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Glycosaminoglycan metabol... | |
medium_hidden_intermediate_03259 | Enterovirus A upregulates a gene that participates in the epigenetic regulation of gene expression. Evidence for this gene reports a log2 fold change of 1.472 and an adjusted p-value of 0.007341. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03259","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A upregulates a gene that participates in the epigenetic regulation of gene expression. Evidence for this gene r... | |
medium_hidden_intermediate_03261 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with SNCA. One of these genes exhibits a log2 fold change of approximately -1.506 and an adjusted p-value of 3.828e-07 in a specific study. Which cellular component is the gene associated with this expression profile locat... | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03261","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with SNCA. One of these ge... | |
medium_hidden_intermediate_03262 | Zika virus downregulates a gene that is involved in the negative regulation of translational initiation. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -2.243 and an adjusted p-value of 0.007016. Which protein is encoded by this specific gene? | RNA-binding protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03262","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the negative regulation of translational initiation. In a study of gliom... | |
medium_hidden_intermediate_03264 | Two genes are structurally linked to Enterovirus A via a 'downregulates' relationship and to plasmacytoid dendritic cells (pDCs) via an 'enriched in' relationship. One of these genes has been reported in a study (GSE103308) with a log2 fold change of approximately -1.272 and an adjusted p-value of 0.01152. Which gene i... | UTS2R | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03264","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Enterovirus A via a 'downregulates' relationship and to plasmacytoid dendritic cells (p... | |
medium_hidden_intermediate_03265 | Hepacivirus C infection is associated with the upregulation of certain genes whose protein products are located in the extracellular region. One such gene exhibits a log2 fold change of 1.172 and an adjusted p-value of 0.01714 in liver cells. Which protein is encoded by this specific gene? | Cysteine-rich secretory protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03265","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C infection is associated with the upregulation of certain genes whose protein products are located in the extra... | |
medium_hidden_intermediate_03266 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in the regulation of cell shape. Evidence for this gene reports a log2 fold change of -1.272 and an adjusted p-value of 0.03558. Which cellular component is this gene located in? | extracellular space | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03266","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in the regulation of cell shape.... | |
medium_hidden_intermediate_03267 | A gene is upregulated by Primate bocaparvovirus 1 and is enriched in Naive CD8+ T cells. Evidence for this gene reports a log2 fold change of 1.292 and an adjusted p-value of 0.04306. Which protein is encoded by this gene? | Fc receptor-like protein 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03267","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and is enriched in Naive CD8+ T cells. Evidence for this gene reports a lo... | |
medium_hidden_intermediate_03268 | Measles morbillivirus downregulates a gene that participates in post-translational protein modification. Experimental data for this gene shows a log2 fold change of -1.664 and an adjusted p-value of 0.00497. Which gene interacts with this downregulated gene? | EXT2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03268","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus downregulates a gene that participates in post-translational protein modification. Experimental data f... | |
medium_hidden_intermediate_03269 | In a study of macrophages (GSE108897), a gene is identified as being downregulated by Human immunodeficiency virus 1 and serving as a biomarker for schizophrenia. This specific gene exhibits a log2 fold change of approximately -3.63 and an adjusted p-value of approximately 0.0303. Which protein is encoded by this gene? | Sodium- and chloride-dependent betaine transporter | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03269","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified as being downregulated by Human immunodeficiency virus 1 and ser... | |
medium_hidden_intermediate_03270 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Neddylation. One of these genes exhibits a log2 fold change of 1.022 and an adjusted p-value of 0.001134 in lung tissue. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03270","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Neddylation. One of th... | |
medium_hidden_intermediate_03271 | Two genes are structurally linked to Influenza A virus via a downregulation relationship and to eosinophils via an enrichment relationship. One of these genes has been reported in a study (GSE147507) with a log2 fold change of -1.197 and an adjusted p-value of 5.916e-05. Which disease is associated with this specific g... | lung cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03271","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Influenza A virus via a downregulation relationship and to eosinophils via an enrichmen... | |
medium_hidden_intermediate_03272 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Signaling by Receptor Tyrosine Kinases. One of these genes shows a log2 fold change of 1.980 and an adjusted p-value of 0.0269 in bronchial epithelial cells. Which disease is associated with this specific gene as a bio... | familial glucocorticoid deficiency | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03272","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Signaling by Receptor ... | |
medium_hidden_intermediate_03273 | A protein entity is linked to PIK3CG via a binding interaction and is involved in Co-stimulation by CD28. Evidence regarding this entity states: 'Using GFP-tagged PI3K gamma subunits expressed in HEK cells, we show that G beta gamma recruits the enzyme from the cytosol to the membrane by interaction with its regulatory... | Phosphoinositide 3-kinase regulatory subunit 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03273","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A protein entity is linked to PIK3CG via a binding interaction and is involved in Co-stimulation by CD28. Evidence regarding... | |
medium_hidden_intermediate_03275 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which in turn encodes a protein that binds to NCBP1. The expression data for this gene shows a log2 fold change of approximately -1.36 and an adjusted p-value of 0.0134. Which protein is... | Little elongation complex subunit 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03275","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_03277 | Human immunodeficiency virus 1 upregulates a gene that participates in the metabolism of amino acids and derivatives. Evidence for this gene reports a log2 fold change of 1.520 and an adjusted p-value of 4.112e-05. Which disease is connected to this gene through genomic alterations? | renal hypomagnesemia 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03277","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in the metabolism of amino acids and derivatives. Eviden... | |
medium_hidden_intermediate_03278 | Zika virus downregulates a specific gene, the product of which interacts with USP7. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -1.751 and an adjusted p-value of 0.004702. Which protein is encoded by this gene? | OTU domain-containing protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03278","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, the product of which interacts with USP7. In a study of glioma stem cells (GSE1149... | |
medium_hidden_intermediate_03279 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in the cellular response to heat stress. Experimental data for this gene reports a log2 fold change of -1.131 and an adjusted p-value of 0.02607. Which protein is encoded by this gene? | Heat shock 70 kDa protein 4L | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03279","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in the cellular response t... | |
medium_hidden_intermediate_03282 | Human immunodeficiency virus 1 upregulates a gene that is involved in the positive regulation of the BMP signaling pathway. Experimental data from a study on macrophages (GSE108897) indicates that this gene has a log2 fold change of approximately 1.671 and an adjusted p-value of 7.126e-05. Which protein is encoded by t... | F-box/LRR-repeat protein 15 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03282","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is involved in the positive regulation of the BMP signaling pathway. ... | |
medium_hidden_intermediate_03283 | Identify the gene that is upregulated by Human immunodeficiency virus 1 and located in the endoplasmic reticulum, for which experimental data reports a log2 fold change of 1.895 and an adjusted p-value of 0.01647. Which cell type is this gene enriched in? | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03283","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Identify the gene that is upregulated by Human immunodeficiency virus 1 and located in the endoplasmic reticulum, for which ... | |
medium_hidden_intermediate_03285 | Zika virus downregulates a specific gene that participates in G2/M Checkpoints. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -1.457 and an adjusted p-value of 0.009657. Which disease is associated with this gene? | leiomyoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03285","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in G2/M Checkpoints. In a study of glioma stem cells (GSE114907),... | |
medium_hidden_intermediate_03288 | Human immunodeficiency virus 1 downregulates a gene that participates in gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of -1.558 and an adjusted p-value of 0.004549. Which protein is encoded by this gen... | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03288","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in gamma carboxylation, hypusinylation, hydroxylation,... | |
medium_hidden_intermediate_03289 | Pegivirus C is linked to gastric cancer via a downregulation relationship with an intermediate gene, which serves as a biomarker for the disease. One such intermediate gene exhibits a log2 fold change of -1.386 and an adjusted p-value of 0.02067 in peripheral blood mononuclear cells (study GSE131504). Which protein is ... | Transcription factor AP-4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03289","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is linked to gastric cancer via a downregulation relationship with an intermediate gene, which serves as a bioma... | |
medium_hidden_intermediate_03290 | Pegivirus C is reported to downregulate a specific gene, the product of which interacts with RBX1. In a study of peripheral blood mononuclear cells (GSE131504), this gene exhibited a log2 fold change of -1.614 and an adjusted p-value of 0.003204. Which protein is encoded by this gene? | F-box DNA helicase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03290","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, the product of which interacts with RBX1. In a study of peripheral ... | |
medium_hidden_intermediate_03291 | Hepacivirus C upregulates a gene that participates in PIP3 activates AKT signaling. Evidence for one such gene reports a log2 fold change of 1.806 and an adjusted p-value of 0.01037. Which protein is encoded by that gene? | Ragulator complex protein LAMTOR4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03291","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in PIP3 activates AKT signaling. Evidence for one such gene reports a log... | |
medium_hidden_intermediate_03292 | Human immunodeficiency virus 1 upregulates a gene that participates in cell junction organization. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of 1.223 and an adjusted p-value of 0.006015. Which protein is encoded by this specific gene? | Alpha-parvin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03292","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in cell junction organization. In a study of macrophages... | |
medium_hidden_intermediate_03295 | Zika virus downregulates a specific gene, the product of which binds to INO80E. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -2.836 and an adjusted p-value of 0.002914. Which protein is encoded by this gene? | Actin-related protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03295","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, the product of which binds to INO80E. In a study of glioma stem cells (GSE114907),... | |
medium_hidden_intermediate_03296 | A gene is upregulated by Measles morbillivirus and located in the centriole. Evidence for this gene in pleural mesothelioma cells (study GSE117668) reports a log2 fold change of approximately 1.64 and an adjusted p-value of approximately 0.00028. Which disease is associated with this gene through genomic alterations? | Alzheimer disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03296","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and located in the centriole. Evidence for this gene in pleural mesothelioma ... | |
medium_hidden_intermediate_03299 | Hepacivirus C upregulates a gene that is involved in the UDP-N-acetylglucosamine biosynthetic process. Evidence for one such gene reports a log2 fold change of approximately 1.004 and an adjusted p-value of 0.01478. Which cell type is this gene enriched in? | mucosal-associated invariant T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03299","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in the UDP-N-acetylglucosamine biosynthetic process. Evidence for one such... | |
medium_hidden_intermediate_03300 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the Pentose phosphate pathway. One of these genes exhibits a log2 fold change of 1.515 and an adjusted p-value of 0.0424 in a specific study. Which protein is encoded by this gene? | Phosphopentomutase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03300","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the Pentose phosphate ... | |
medium_hidden_intermediate_03301 | A gene is upregulated by Human immunodeficiency virus 1 and is involved in the inflammatory response. Evidence for this gene reports a log2 fold change of 1.614 and an adjusted p-value of 0.007974. Which disease is associated with this gene as a biomarker? | Endometrial carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03301","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human immunodeficiency virus 1 and is involved in the inflammatory response. Evidence for this gene... | |
medium_hidden_intermediate_03304 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A was found to upregulate a specific gene that enables protein homodimerization activity. This gene exhibited a log2 fold change of approximately 2.008 and an adjusted p-value of 0.0041. Which gene interacts with this upregulated gene? | GRHL3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03304","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A was found to upregulate a specific gene that enables protein... | |
medium_hidden_intermediate_03308 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and enriched in mucosa-associated invariant T (MAIT) cells. This gene exhibits a log2 fold change of approximately 1.456 and an adjusted p-value of 2.557e-06. Which biological process is this gene invo... | positive regulation of protein neddylation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03308","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and e... | |
medium_hidden_intermediate_03309 | Two genes are structurally linked to germ cells via a 'has marker' relationship and to intracellular protein transport via an 'involved in' relationship. One of these genes is described in literature as colocalizing with early endosome antigen 1 (EEA1) and retromer components, suggesting endosomal localization and invo... | naive B cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03309","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to germ cells via a 'has marker' relationship and to intracellular protein transport via a... | |
medium_hidden_intermediate_03310 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to head and neck squamous cell carcinoma via biomarker association. One of these genes is reported in a study with a log2 fold change of approximately 1.193 and an adjusted p-value of 0.01055. Which protein is encoded by ... | Zinc finger protein 195 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03310","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to head and neck squamous... | |
medium_hidden_intermediate_03312 | In a study of monocytic leukemia cell lines (GSE114966), Human alphaherpesvirus 1 upregulates a specific gene, which in turn interacts with ESR1. This gene exhibits a log2 fold change of approximately 1.538 and an adjusted p-value of 0.00491. Which protein is encoded by this gene? | Swi5-dependent recombination DNA repair protein 1 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03312","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of monocytic leukemia cell lines (GSE114966), Human alphaherpesvirus 1 upregulates a specific gene, which in turn... |
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