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medium_hidden_intermediate_03313 | Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to Memory CD8+ T cells via an 'enriched in' relationship. One of these genes is associated with experimental data showing a log2 fold change of approximately -1.184 and an adjusted p-value of 0.005712. Which cellu... | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03313","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to Memory CD8+ T ... | |
medium_hidden_intermediate_03314 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and its product is located in the extracellular space. Evidence for this gene reports a log2 fold change of 1.364 and an adjusted p-value of 0.007566. Which protein is encoded by this gene? | Tumor necrosis factor alpha-induced protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03314","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and i... | |
medium_hidden_intermediate_03315 | Human alphaherpesvirus 1 upregulates a gene that encodes a protein binding to SMC4. In a study of monocytic leukemia cell lines (GSE114966), one such gene showed a log2 fold change of 3.710 and an adjusted p-value of 0.003573. Which protein is encoded by this gene? | Condensin complex subunit 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03315","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that encodes a protein binding to SMC4. In a study of monocytic leukemia cell li... | |
medium_hidden_intermediate_03318 | A gene is upregulated by Measles morbillivirus and enriched in non-classical monocytes. Experimental data for this gene reports a log2 fold change of approximately 1.053 and an adjusted p-value of 0.001022. Which biological process is this gene involved in? | hypoxanthine transport | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03318","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and enriched in non-classical monocytes. Experimental data for this gene repo... | |
medium_hidden_intermediate_03319 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific gene that is involved in protein ubiquitination. This gene exhibited a log2 fold change of approximately -1.036 and an adjusted p-value of 0.02365. Which cellular component is this gene located in? | Cul5-RING ubiquitin ligase complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03319","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific g... | |
medium_hidden_intermediate_03322 | In a study of Influenza A virus infection, a specific gene is downregulated by the virus and is enriched in non-classical monocytes. Evidence for this gene reports a log2 fold change of -2.223 and an adjusted p-value of 1.037e-05. Which protein is encoded by this gene? | Platelet-derived growth factor C | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03322","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is downregulated by the virus and is enriched in non-classical mo... | |
medium_hidden_intermediate_03323 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Phase II - Conjugation of compounds. Experimental evidence for this gene reports a log2 fold change of approximately -1.02 and an adjusted p-value of approximately 0.0089. Which disease is associated with this gene thro... | colorectal carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03323","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Phase II - Conjugation ... | |
medium_hidden_intermediate_03324 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and enable ubiquitin-protein transferase activity. One of these genes exhibits a log2 fold change of approximately -1.14 and an adjusted p-value of 0.004. Which cellular component is the location of this specific gene? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03324","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and enable ubiquitin-protein transferas... | |
medium_hidden_intermediate_03325 | Zika virus upregulates a gene that participates in post-translational protein modification. Evidence for this gene in glioblastoma multiforme cancer stem cells reports a log2 fold change of approximately 1.57 and an adjusted p-value of approximately 0.0098. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03325","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that participates in post-translational protein modification. Evidence for this gene in gliobl... | |
medium_hidden_intermediate_03326 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and both interact with RC3H2. One of these genes exhibits a log2 fold change of 1.733 and an adjusted p-value of 0.04987 in a specific study. Which disease is associated with this specific gene? | leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03326","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and both interact with RC3H2. One of thes... | |
medium_hidden_intermediate_03327 | In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to downregulate a specific gene, which is also associated with schizophrenia. The expression data for this gene shows a log2 fold change of -2.576 and an adjusted p-value of 0.003407. Which protein is en... | Homeobox protein OTX1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03327","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to down... | |
medium_hidden_intermediate_03328 | In a study of choroid plexus epithelium (GSE157852), a gene upregulated by Severe acute respiratory syndrome-related coronavirus and involved in Potassium Channels activity showed a log2 fold change of 1.441 and an adjusted p-value of 4.62e-05. Which cellular component is this gene located in? | voltage-gated potassium channel complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03328","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), a gene upregulated by Severe acute respiratory syndrome-related coronav... | |
medium_hidden_intermediate_03334 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific gene, which in turn participates in post-translational protein modification. This gene exhibited a log2 fold change of approximately -2.26 and an adjusted p-value of 0.0158. Which protein is encode... | Glycoprotein endo-alpha-1,2-mannosidase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03334","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific g... | |
medium_hidden_intermediate_03337 | Human immunodeficiency virus 1 downregulates a gene that is located in the cytoplasmic vesicle. Evidence for this gene reports a log2 fold change of -1.062 and an adjusted p-value of 0.01604. Which protein is encoded by this gene? | TBC1 domain family member 2A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03337","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is located in the cytoplasmic vesicle. Evidence for this gene repor... | |
medium_hidden_intermediate_03338 | Zika virus downregulates a gene that interacts with YWHAB. In glioma stem cells, one such downregulated gene exhibits a log2 fold change of -2.298 and an adjusted p-value of 0.01368. Which protein is encoded by this specific gene? | Regulator of microtubule dynamics protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03338","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with YWHAB. In glioma stem cells, one such downregulated gene exhibits a log2... | |
medium_hidden_intermediate_03339 | Human betaherpesvirus 5 downregulates a gene that enables sequence-specific double-stranded DNA binding. Evidence for one such gene reports a log2 fold change of -1.020 and an adjusted p-value of 0.04313. Which disease is associated with that gene through genomic alterations? | congenital anomaly of kidney and urinary tract | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03339","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 downregulates a gene that enables sequence-specific double-stranded DNA binding. Evidence for one su... | |
medium_hidden_intermediate_03340 | Interleukin-6 (IL6) is involved in a biological process that is a subtype of positive regulation of cytokine production. Evidence indicates that IL6 plays a critical role in the development of the Th17 response and the inhibition of Treg functions. Which specific biological process, connected to IL6, is positively regu... | interleukin-17 production | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03340","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Interleukin-6 (IL6) is involved in a biological process that is a subtype of positive regulation of cytokine production. Evi... | |
medium_hidden_intermediate_03343 | Two genes are linked to Enterovirus A via downregulation and to acute lymphoblastic leukemia via association. One of these genes exhibits a log2 fold change of -2.698 and an adjusted p-value of 0.004291 in rhabdomyosarcoma cells. Which protein is encoded by this specific gene? | Homeobox protein Hox-A11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03343","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Enterovirus A via downregulation and to acute lymphoblastic leukemia via association. One of these g... | |
medium_hidden_intermediate_03344 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the cytokine-mediated signaling pathway. Evidence for this gene reports a log2 fold change of 1.148 and an adjusted p-value of 4.001e-18. Which protein is encoded by this gene? | Proteolipid protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03344","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the cytokine-mediated signaling... | |
medium_hidden_intermediate_03345 | In a study of macrophages (GSE108897), a gene upregulated by Human immunodeficiency virus 1 and involved in Glycosaminoglycan metabolism showed a log2 fold change of 1.726 and an adjusted p-value of 1.075e-05. Which disease is associated with this specific gene? | mammary neoplasms, animal | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03345","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene upregulated by Human immunodeficiency virus 1 and involved in Glycosaminoglyca... | |
medium_hidden_intermediate_03346 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of certain genes whose protein products are located in the AP-1 adaptor complex. One such gene exhibits a log2 fold change of 1.087 and an adjusted p-value of 0.01836. Which protein is encoded by this specific gene? | Synergin gamma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03346","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of certain genes whose p... | |
medium_hidden_intermediate_03347 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in nervous system development. Evidence for this gene reports a log2 fold change of approximately 1.27 and an adjusted p-value of approximately 0.017. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03347","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in nervous system development... | |
medium_hidden_intermediate_03351 | Human betaherpesvirus 5 upregulates multiple genes that are located in extracellular exosomes. One such gene exhibits a log2 fold change of 1.618 and an adjusted p-value of 3.624e-05. Which molecular function is enabled by this specific gene? | serine-type peptidase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03351","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates multiple genes that are located in extracellular exosomes. One such gene exhibits a log2... | |
medium_hidden_intermediate_03352 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes located in the plasma membrane. One such gene exhibits a log2 fold change of approximately -1.158 and an adjusted p-value of 0.0011. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03352","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes locat... | |
medium_hidden_intermediate_03353 | A gene is identified as a marker for Beta cells (β cells) and is annotated with the function of enabling protein binding. Experimental evidence indicates that this gene encodes a member of the tetraspanin family that interacts with hTHTR-1. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03353","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is identified as a marker for Beta cells (β cells) and is annotated with the function of enabling protein binding. Ex... | |
medium_hidden_intermediate_03357 | Enterovirus A upregulates a gene that interacts with RPA3. In a study of rhabdomyosarcoma cells (GSE103308), one such gene showed a log2 fold change of 1.224 and an adjusted p-value of 0.01827. Which protein is encoded by this gene? | Testis-expressed protein 10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03357","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A upregulates a gene that interacts with RPA3. In a study of rhabdomyosarcoma cells (GSE103308), one such gene s... | |
medium_hidden_intermediate_03358 | Hepacivirus C is reported to downregulate a gene that is enriched in Mucosa-associated invariant T (MAIT) cells. Evidence for this specific gene shows a log2 fold change of -1.159 and an adjusted p-value of 7.125e-05. Which protein is encoded by this gene? | Thymus-specific serine protease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03358","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that is enriched in Mucosa-associated invariant T (MAIT) cells. Evidence fo... | |
medium_hidden_intermediate_03359 | Zaire ebolavirus upregulates a gene that interacts with RPA2. In a study of retinal pigment epithelium cells (GSE100839), one such gene showed a log2 fold change of 1.098 and an adjusted p-value of 2.088e-06. What molecular function is enabled by this specific gene? | methyltransferase cap1 activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03359","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus upregulates a gene that interacts with RPA2. In a study of retinal pigment epithelium cells (GSE100839), on... | |
medium_hidden_intermediate_03361 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes whose products are located in the plasma membrane. One such gene exhibits a log2 fold change of approximately -1.21 and an adjusted p-value of approximately 0.0028. Which protein is encoded by this spe... | Histamine H1 receptor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03361","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes whose... | |
medium_hidden_intermediate_03363 | A gene is upregulated by Human gammaherpesvirus 8 and enriched in natural killer cells. Evidence for this gene in a non-Hodgkin lymphoma cell line (study GSE119608) reports a log2 fold change of approximately 3.17 and an adjusted p-value of approximately 0.0338. Which cellular component is this gene located in? | cytosol | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03363","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human gammaherpesvirus 8 and enriched in natural killer cells. Evidence for this gene in a non-Hodg... | |
medium_hidden_intermediate_03364 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in the metabolism of water-soluble vitamins and cofactors. One of these genes exhibits a log2 fold change of approximately -2.81 and an adjusted p-value of approximately 0.043. Which cellular component is the protein pr... | extracellular space | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03364","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in the metabolism of wa... | |
medium_hidden_intermediate_03365 | Two genes are upregulated by Measles morbillivirus and serve as biomarkers for breast cancer. One of these genes exhibits a log2 fold change of 1.664 and an adjusted p-value of 0.04641 in study GSE131840. Which disease is associated with this specific gene? | leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03365","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Measles morbillivirus and serve as biomarkers for breast cancer. One of these genes exhibits a ... | |
medium_hidden_intermediate_03366 | Rhinovirus A infection is associated with the downregulation of specific genes that are enriched in Regulatory T (Treg) cells. One such gene exhibits a log2 fold change of -2.163 and an adjusted p-value of 0.001002 in cytotoxic T-lymphocytes (based on study GSE106475). Which protein is encoded by this gene? | Epithelial-stromal interaction protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03366","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection is associated with the downregulation of specific genes that are enriched in Regulatory T (Treg) cell... | |
medium_hidden_intermediate_03367 | Human immunodeficiency virus 1 upregulates a gene that participates in nervous system development. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately 1.20 and an adjusted p-value of approximately 0.00033. Which protein does this gene interact with? | DPYSL2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03367","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in nervous system development. In a study of macrophages... | |
medium_hidden_intermediate_03369 | In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and enables transcription corepressor activity. This specific gene exhibits a log2 fold change of -1.845 and an adjusted p-value of 0.01546. Which protein is encoded by this gene? | E3 ubiquitin-protein ligase TRIM22 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03369","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and enab... | |
medium_hidden_intermediate_03370 | Measles morbillivirus upregulates a gene that is involved in the regulation of transcription by RNA polymerase II. Experimental data for this gene shows a log2 fold change of 3.218 and an adjusted p-value of 0.01966. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03370","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is involved in the regulation of transcription by RNA polymerase II. Experimen... | |
medium_hidden_intermediate_03372 | Zika virus downregulates a gene that participates in SUMOylation. Evidence for this gene in glioma stem cells reports a log2 fold change of -1.358 and an adjusted p-value of 0.01016. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03372","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in SUMOylation. Evidence for this gene in glioma stem cells reports a log2... | |
medium_hidden_intermediate_03373 | Two genes are linked to Human immunodeficiency virus 1 via a downregulation relationship and to breast cancer via a biomarker relationship. One of these genes exhibits a log2 fold change of -1.832 and an adjusted p-value of 0.008704 in a specific study. Which cell type is associated with this gene through an enrichment... | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03373","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Human immunodeficiency virus 1 via a downregulation relationship and to breast cancer via a biomarke... | |
medium_hidden_intermediate_03375 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by the virus and participates in the epigenetic regulation of gene expression. Experimental data for this gene reports a log2 fold change of approximately 1.388 and an adjusted p-value of 0.0005631. Wh... | AT-rich interactive domain-containing protein 4B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03375","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by th... | |
medium_hidden_intermediate_03376 | In a study of glioma stem cells (GSE114907), Zika virus infection was found to downregulate a specific gene, which in turn encodes a protein that binds to RFC2. The expression data for this gene shows a log2 fold change of approximately -1.20 and an adjusted p-value of 0.0085. Which protein is encoded by this gene? | Nibrin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03376","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), Zika virus infection was found to downregulate a specific gene, which in turn e... | |
medium_hidden_intermediate_03377 | In a study of monocytic leukemia cells (GSE114966), Human alphaherpesvirus 1 infection leads to the upregulation of specific histone variants that participate in the B-WICH complex-mediated positive regulation of rRNA expression. One such upregulated entity exhibits a log2 fold change of 2.282 and an adjusted p-value o... | Histone H3.1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03377","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of monocytic leukemia cells (GSE114966), Human alphaherpesvirus 1 infection leads to the upregulation of specific... | |
medium_hidden_intermediate_03379 | Lepirudin and Mefenamic acid are both known to interact with a specific third drug. Clinical evidence from the HIT-4 trial discusses the use of Recombinant hirudin (lepirudin) to improve thrombolysis outcomes when combined with this specific drug in patients suffering from acute myocardial infarction. What disease is t... | pulmonary embolism | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03379","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Lepirudin and Mefenamic acid are both known to interact with a specific third drug. Clinical evidence from the HIT-4 trial d... | |
medium_hidden_intermediate_03380 | Hepacivirus C upregulates a gene that is involved in retrograde transport from the endosome to the Golgi. Evidence for one such gene reports a log2 fold change of 1.358 and an adjusted p-value of 0.03238. Which protein is encoded by that gene? | Vacuolar protein sorting-associated protein 26A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03380","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in retrograde transport from the endosome to the Golgi. Evidence for one s... | |
medium_hidden_intermediate_03381 | Hepacivirus C upregulates a gene that enables protease binding. Evidence for one such gene reports a log2 fold change of 1.141 and an adjusted p-value of 0.006088. Which protein is encoded by that gene? | Peroxisomal leader peptide-processing protease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03381","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that enables protease binding. Evidence for one such gene reports a log2 fold change of 1.1... | |
medium_hidden_intermediate_03385 | Pegivirus C is reported to downregulate a specific gene, which in turn participates in cellular responses to stress. Transcriptomic data from peripheral blood mononuclear cells (study GSE131504) indicates that this gene has a log2 fold change of approximately -1.61 and an adjusted p-value of 0.022. Which cellular compo... | nuclear envelope | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03385","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn participates in cellular responses to stress. Transcr... | |
medium_hidden_intermediate_03386 | In a study of umbilical vein endothelial cells (GSE119608), a gene is identified as being downregulated by Human gammaherpesvirus 8 and located in the endoplasmic reticulum. This specific gene exhibits a log2 fold change of approximately -2.32 and an adjusted p-value of approximately 0.035. Which protein is encoded by ... | Peptidyl-prolyl cis-trans isomerase FKBP2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03386","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of umbilical vein endothelial cells (GSE119608), a gene is identified as being downregulated by Human gammaherpes... | |
medium_hidden_intermediate_03387 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Epigenetic regulation of gene expression. Experimental data for this gene in a colonic adenocarcinoma cell line (study GSE148729) reports a log2 fold change of approximately -1.36 and an adjusted p-value of approximatel... | negative regulation of transcription by RNA polymerase II | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03387","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Epigenetic regulation o... | |
medium_hidden_intermediate_03388 | Two genes are structurally linked to Enterovirus A via downregulation and to Post-translational protein modification via participation. One of these genes exhibits a log2 fold change of -1.038 and an adjusted p-value of 0.0259 in rhabdomyosarcoma cells. Which disease is associated with this specific gene as a biomarker... | major depressive disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03388","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Enterovirus A via downregulation and to Post-translational protein modification via par... | |
medium_hidden_intermediate_03389 | Pegivirus C is reported to downregulate a gene that subsequently interacts with RAB5A. In a study of peripheral blood mononuclear cells (GSE131504), one such intermediate gene exhibits a log2 fold change of approximately -1.68 and an adjusted p-value of 0.0032. Which protein is encoded by this specific gene? | Oxysterol-binding protein-related protein 11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03389","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that subsequently interacts with RAB5A. In a study of peripheral blood mononu... | |
medium_hidden_intermediate_03390 | In a study of glioma stem cells (GSE114907), a specific gene is downregulated by Zika virus and interacts with KLHL20. This gene exhibits a log2 fold change of approximately -1.99 and an adjusted p-value of 0.0041. Which protein is encoded by this gene? | Influenza virus NS1A-binding protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03390","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), a specific gene is downregulated by Zika virus and interacts with KLHL20. This ... | |
medium_hidden_intermediate_03391 | Human polyomavirus 1 upregulates a gene that is involved in the positive regulation of D-glucose transmembrane transport. Experimental data from study GSE135833 in renal epithelial cells reports a log2 fold change of 2.166 and an adjusted p-value of 0.007037 for this gene. Which protein is encoded by this gene? | Palmitoyltransferase ZDHHC7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03391","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human polyomavirus 1 upregulates a gene that is involved in the positive regulation of D-glucose transmembrane transport. Ex... | |
medium_hidden_intermediate_03392 | Human respirovirus 3 upregulates a gene that is located in the plasma membrane. Evidence for this gene in non-small cell lung adenocarcinoma cell lines (study GSE147507) reports a log2 fold change of 3.456 and an adjusted p-value of 0.04933. Which protein is encoded by this gene? | Lysosome-associated membrane glycoprotein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03392","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human respirovirus 3 upregulates a gene that is located in the plasma membrane. Evidence for this gene in non-small cell lun... | |
medium_hidden_intermediate_03393 | A gene is downregulated by Human gammaherpesvirus 8 and its expression is enriched in non-classical monocytes. Experimental data for this gene reports a log2 fold change of approximately -2.57 and an adjusted p-value of approximately 0.0052. Which protein is encoded by this gene? | CD83 antigen | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03393","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Human gammaherpesvirus 8 and its expression is enriched in non-classical monocytes. Experimental ... | |
medium_hidden_intermediate_03395 | A gene is downregulated by Primate bocaparvovirus 1 and participates in nervous system development. Experimental evidence for this gene reports a log2 fold change of -1.075 and an adjusted p-value of 0.009963. Which protein is encoded by this gene? | Protein kinase C-binding protein NELL2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03395","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and participates in nervous system development. Experimental evidence fo... | |
medium_hidden_intermediate_03399 | In a study of Measles morbillivirus infection, two genes are known to be upregulated by the virus and to interact with RAB11A. One of these genes exhibits a log2 fold change of approximately 1.75 and an adjusted p-value of approximately 0.0499. What is the protein encoded by this specific gene? | Amyloid beta precursor protein binding family B member 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03399","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, two genes are known to be upregulated by the virus and to interact with RAB11... | |
medium_hidden_intermediate_03401 | A gene is downregulated by Human immunodeficiency virus 1 and is involved in chemical synaptic transmission. Transcriptomic data for this gene in macrophages (from study GSE108897) reports a log2 fold change of -4.624 and an adjusted p-value of 0.01779. Which disease is associated with this gene as a biomarker? | substance dependence | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03401","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Human immunodeficiency virus 1 and is involved in chemical synaptic transmission. Transcriptomic ... | |
medium_hidden_intermediate_03402 | In the context of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and involved in the apoptotic process. Experimental data for this gene in choroid plexus epithelium cells (from study GSE157852) reports a log2 fold change of approximately 4.316 and an adjusted p-value of ... | Bcl-2-like protein 10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03402","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In the context of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and involv... | |
medium_hidden_intermediate_03403 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in immunoregulatory interactions between a lymphoid and a non-lymphoid cell. Evidence for one such gene reports a log2 fold change of -1.212 and an adjusted p-value of 2.369e-06. Which protein does this gene product bind to? | SLAMF6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03403","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in immunoregulatory interaction... | |
medium_hidden_intermediate_03404 | Zaire ebolavirus upregulates a gene that is enriched in neutrophils. Evidence for this gene reports a log2 fold change of 1.193 and an adjusted p-value of 0.0178. Which biological process is this gene involved in? | positive regulation of inflammatory response | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03404","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus upregulates a gene that is enriched in neutrophils. Evidence for this gene reports a log2 fold change of 1.... | |
medium_hidden_intermediate_03406 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the retinoic acid metabolic process. Experimental evidence for this gene reports a log2 fold change of approximately 1.94 and an adjusted p-value of approximately 0.0044. Which cellular component is this gene located in? | mitochondrion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03406","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the retinoic acid metaboli... | |
medium_hidden_intermediate_03408 | In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and participates in Signaling by NTRKs. Experimental data for this gene shows a log2 fold change of 1.886 and an adjusted p-value of 0.02647. Which protein is encoded by this gene? | Cyclic AMP-dependent transcription factor ATF-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03408","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and participates in Signaling by ... | |
medium_hidden_intermediate_03410 | In a study of cervical adenocarcinoma cell lines (GSE11238), a specific gene is downregulated by Vaccinia virus and participates in Gastrulation. This gene exhibits a log2 fold change of approximately -1.10 and an adjusted p-value of 0.007. Which protein is encoded by this gene? | Transcription factor 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03410","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a specific gene is downregulated by Vaccinia virus and particip... | |
medium_hidden_intermediate_03413 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate specific host genes involved in poly(A)-specific ribonuclease activity. One such gene exhibited a log2 fold change of -1.298 and an adjusted p-value of 0.007714. Which protein is encoded by this specific gene... | PAN2-PAN3 deadenylation complex subunit PAN3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03413","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate specific hos... | |
medium_hidden_intermediate_03414 | Human betaherpesvirus 5 upregulates a gene that interacts with USP15. Experimental data for this gene in foreskin fibroblast cell lines reports a log2 fold change of 3.664 and an adjusted p-value of 0.02313. Which protein is encoded by this gene? | Serpin B4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03414","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that interacts with USP15. Experimental data for this gene in foreskin fibroblast... | |
medium_hidden_intermediate_03415 | Two genes are structurally linked to TOPBP1 via an 'interacts with' relationship and to protein homodimerization activity via an 'enables' relationship. One of these genes is supported by evidence stating: 'A direct interaction between this gene product and a DNA repair scaffold protein TopBP1 was identified.' Which pr... | Protein CIP2A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03415","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to TOPBP1 via an 'interacts with' relationship and to protein homodimerization activity vi... | |
medium_hidden_intermediate_03416 | Human alphaherpesvirus 3 is known to upregulate certain genes that are subsequently found within extracellular exosomes. One such gene exhibits a log2 fold change of 1.423 and an adjusted p-value of 2.894e-12 in a specific study. Which cell type is this gene enriched in? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03416","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 is known to upregulate certain genes that are subsequently found within extracellular exosomes. One... | |
medium_hidden_intermediate_03418 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is downregulated by the virus and is known to enable signaling receptor binding. This gene exhibits a log2 fold change of approximately -1.197 and an adjusted p-value of 5.916e-05. Which cellular component is this ge... | insulin-like growth factor binary complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03418","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is downregulated by ... | |
medium_hidden_intermediate_03420 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific gene that participates in the RHO GTPase cycle. This gene exhibited a log2 fold change of -1.485 and an adjusted p-value of 0.0006996. Which protein is encoded by this gene? | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03420","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific g... | |
medium_hidden_intermediate_03425 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene located in the cytoplasm was found to be downregulated. This gene exhibited a log2 fold change of approximately -1.018 and an adjusted p-value of 3.07e-06. Which biological process is this gene involved in? | regulation of epithelial to mesenchymal transition | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03425","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene located in the cytop... | |
medium_hidden_intermediate_03426 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and its product is located in the mitotic spindle. Evidence for this gene reports a log2 fold change of -1.233 and an adjusted p-value of 0.005157. Which protein is encoded by this gene? | Transcriptional adapter 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03426","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and its product is located in the mitotic s... | |
medium_hidden_intermediate_03427 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with JUN. One of these genes exhibits a log2 fold change of -1.709 and an adjusted p-value of 0.01671 in a specific study. Which cell type is this gene enriched in? | non-classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03427","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with JUN. One of these gen... | |
medium_hidden_intermediate_03428 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes that participate in G alpha (s) signalling events. One such gene exhibited a log2 fold change of approximately 2.39 and an adjusted p-value of approximately 1.72e-07. Which protein is encoded by t... | 3',5'-cyclic-AMP phosphodiesterase 4A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03428","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes ... | |
medium_hidden_intermediate_03429 | In a study of Hepacivirus C infection in hepatocytes (GSE132606), two genes are upregulated by the virus and interact with RAB7A. One of these genes exhibits a log2 fold change of approximately 1.53 and an adjusted p-value of 0.0148. Which protein is encoded by this specific gene? | Prenylated Rab acceptor protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03429","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Hepacivirus C infection in hepatocytes (GSE132606), two genes are upregulated by the virus and interact with R... | |
medium_hidden_intermediate_03430 | In a study of macrophages (GSE108897), a gene upregulated by Human immunodeficiency virus 1 and participating in Vesicle-mediated transport was found to have a log2 fold change of 1.990 and an adjusted p-value of 0.002621. Which biological process is this gene involved in? | regulation of endocytosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03430","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene upregulated by Human immunodeficiency virus 1 and participating in Vesicle-med... | |
medium_hidden_intermediate_03432 | Zika virus downregulates a specific gene that is involved in the negative regulation of cell migration. Experimental data for this gene in glioma stem cells (from study GSE114907) reports a log2 fold change of approximately -3.07 and an adjusted p-value of approximately 0.042. In which cell type is this gene enriched? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03432","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is involved in the negative regulation of cell migration. Experimental data fo... | |
medium_hidden_intermediate_03433 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the post-translational modification: synthesis of GPI-anchored proteins. Evidence for this gene reports a log2 fold change of 2.046 and an adjusted p-value of 0.04403. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03433","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the post-translational modific... | |
medium_hidden_intermediate_03435 | A gene is downregulated by Human gammaherpesvirus 8 and participates in Hemostasis. Experimental data for this gene in umbilical vein endothelial cells shows a log2 fold change of approximately -1.52 and an adjusted p-value of 0.0054. Which protein does this gene product interact with? | RHOA | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03435","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Human gammaherpesvirus 8 and participates in Hemostasis. Experimental data for this gene in umbil... | |
medium_hidden_intermediate_03436 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with SLC39A4. One of these genes was reported in a study (GSE155241) on lung cells with a log2 fold change of 1.130 and an adjusted p-value of 0.003956. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03436","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with SLC39A4. One of these g... | |
medium_hidden_intermediate_03437 | Zika virus downregulates a gene that participates in the mitotic cell cycle. Evidence for this gene in glioma stem cells reports a log2 fold change of -1.777 and an adjusted p-value of 0.006234. Which cell type is this gene enriched in? | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03437","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in the mitotic cell cycle. Evidence for this gene in glioma stem cells rep... | |
medium_hidden_intermediate_03439 | Pegivirus C is reported to downregulate a specific gene that participates in GPCR downstream signalling. In a study of peripheral blood mononuclear cells (GSE131504), this gene exhibited a log2 fold change of -1.486 and an adjusted p-value of 0.008868. What molecular function is enabled by this gene? | leukotriene receptor activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03439","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene that participates in GPCR downstream signalling. In a study of perip... | |
medium_hidden_intermediate_03440 | Human alphaherpesvirus 3 upregulates a gene that is involved in the response to virus. Evidence for one such gene reports a log2 fold change of 3.054 and an adjusted p-value of 4.123e-11. Which disease is associated with that gene as a biomarker? | hypersensitivity pneumonitis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03440","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 upregulates a gene that is involved in the response to virus. Evidence for one such gene reports a ... | |
medium_hidden_intermediate_03442 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene that is located in the nucleoplasm. This gene exhibited a log2 fold change of approximately 1.129 and an adjusted p-value of 0.0007972. What molecular function is enabled by this gene? | AMP kinase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03442","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene that is lo... | |
medium_hidden_intermediate_03443 | Pegivirus C is reported to downregulate a specific gene, which is subsequently involved in the positive regulation of transcription by RNA polymerase II. Experimental data for this gene indicates a log2 fold change of approximately -1.585 and an adjusted p-value of 0.001832. In which cell type is this gene enriched? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03443","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which is subsequently involved in the positive regulation of transc... | |
medium_hidden_intermediate_03444 | In the context of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and participates in Pyruvate metabolism. Experimental data for this gene in lung tissue shows a log2 fold change of approximately 1.042 and an adjusted p-value of 0.003368. Which protein does this gene prod... | WDR26 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03444","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In the context of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and partic... | |
medium_hidden_intermediate_03445 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in the regulation of DNA-templated transcription. Evidence for this specific gene reports a log2 fold change of -2.115 and an adjusted p-value of 0.03541. Which protein is encoded by this gene? | Estrogen-related receptor gamma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03445","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in the regulation of DNA-templat... | |
medium_hidden_intermediate_03446 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the basolateral plasma membrane. Evidence for one such gene reports a log2 fold change of 1.465 and an adjusted p-value of 0.01058. Which gene interacts with this upregulated gene? | TRPC5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03446","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the basolateral plasma membrane.... | |
medium_hidden_intermediate_03450 | In a study of non-small cell lung adenocarcinoma, Influenza A virus infection was found to upregulate a specific gene, which is involved in the positive regulation of cold-induced thermogenesis. This gene exhibited a log2 fold change of 1.624 and an adjusted p-value of 0.004653. Which protein is encoded by this gene? | Long-chain specific acyl-CoA dehydrogenase, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03450","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma, Influenza A virus infection was found to upregulate a specific gene, which... | |
medium_hidden_intermediate_03451 | Zika virus downregulates a specific gene that participates in diseases of glycosylation. Experimental data from glioma stem cells (study GSE114907) indicates this gene has a log2 fold change of -1.017 and an adjusted p-value of 0.03684. Which disease is associated with this gene? | proteinuria | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03451","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in diseases of glycosylation. Experimental data from glioma stem ... | |
medium_hidden_intermediate_03452 | Pegivirus C is reported to downregulate a gene that participates in the transcriptional activation of mitochondrial biogenesis. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -1.147 and an adjusted p-value of 0.001599. Which protein is encoded b... | Acetyl-coenzyme A synthetase, cytoplasmic | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03452","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that participates in the transcriptional activation of mitochondrial biogenes... | |
medium_hidden_intermediate_03454 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to upregulate a specific gene that participates in collagen formation. This gene exhibited a log2 fold change of approximately 1.19 and an adjusted p-value of approximately 0.0102. Which protein is encoded by this gene? | Lysyl oxidase homolog 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03454","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_03455 | Zika virus downregulates a specific gene that is involved in the positive regulation of canonical NF-kappaB signal transduction. Experimental data for this gene indicates a log2 fold change of approximately -3.51 and an adjusted p-value of 0.0043. In which cell type is this gene enriched? | naive B cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03455","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is involved in the positive regulation of canonical NF-kappaB signal transduct... | |
medium_hidden_intermediate_03456 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with HIST1H1C. One of these genes shows a log2 fold change of approximately 1.27 and an adjusted p-value of 7.129e-07 in a specific study. Which protein is encoded by this gene? | Kanadaptin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03456","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with HIST1H1C. One of these ... | |
medium_hidden_intermediate_03457 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which in turn participates in RNA Polymerase II transcription. This gene exhibits a log2 fold change of -1.759 and an adjusted p-value of 0.01654. Which biological process is this gene i... | regulation of DNA-templated transcription | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03457","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_03460 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the positive regulation of actin filament polymerization. Evidence for this gene reports a log2 fold change of 2.585 and an adjusted p-value of 0.009655. Which protein is encoded by this gene? | C-C motif chemokine 26 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03460","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the positive regulation of acti... | |
medium_hidden_intermediate_03462 | Zaire ebolavirus downregulates a gene that serves as a biomarker for obesity disorder. In a study of retinal pigment epithelium cells (GSE100839), one such gene exhibited a log2 fold change of -1.395 and an adjusted p-value of 4.424e-06. Which protein is encoded by this specific gene? | Transient receptor potential cation channel subfamily V member 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03462","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus downregulates a gene that serves as a biomarker for obesity disorder. In a study of retinal pigment epithel... | |
medium_hidden_intermediate_03463 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which in turn enables DNA binding. This gene exhibits a log2 fold change of approximately -2.17 and an adjusted p-value of 0.018. Which biological process is this gene involved in? | positive regulation of transcription by RNA polymerase II | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03463","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_03464 | In a study of glioma stem cells (GSE114907), a gene is downregulated by Zika virus and interacts with TP53. This specific gene exhibits a log2 fold change of -1.986 and an adjusted p-value of 0.006285. Which disease is associated with this gene? | carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03464","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), a gene is downregulated by Zika virus and interacts with TP53. This specific ge... | |
medium_hidden_intermediate_03465 | A gene is downregulated by Cardiovirus A and is enriched in plasmacytoid dendritic cells. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of approximately -1.267 and an adjusted p-value of 0.03558. Which cellular component is this gene located in? | endoplasmic reticulum | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03465","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Cardiovirus A and is enriched in plasmacytoid dendritic cells. Experimental data for this gene in... | |
medium_hidden_intermediate_03466 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and known to interact with BAG3 exhibits a log2 fold change of approximately 2.06 and an adjusted p-value of 3.545e-08. Which protein is encoded by this specific gene? | Galactokinase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03466","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and known to interact with... | |
medium_hidden_intermediate_03467 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and both bind to CTNNA2. One of these genes exhibits a log2 fold change of -2.633 and an adjusted p-value of 0.003446 in sclera tissue (study GSE164073). Which disease is associated with this specific gene as a biomarker? | alcohol abuse | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03467","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and both bind to CTNNA2. One of these g... |
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