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medium_hidden_intermediate_03469 | In studies of Severe acute respiratory syndrome-related coronavirus infection, certain genes are downregulated and their products interact with FGFR1. One such gene exhibits a log2 fold change of -1.392 and an adjusted p-value of 0.02607. Which protein is encoded by this specific gene? | Aldehyde dehydrogenase family 3 member A2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03469","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In studies of Severe acute respiratory syndrome-related coronavirus infection, certain genes are downregulated and their pro... | |
medium_hidden_intermediate_03471 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to tuberculosis via an association relationship. One of these genes was reported in a study (GSE164073) involving sclera cells, with a log2 fold change of approximately 1.319 and an adjusted p-value of app... | Membrane-associated phosphatidylinositol transfer protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03471","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to tuberc... | |
medium_hidden_intermediate_03472 | Pegivirus C is reported to downregulate a specific gene, which is located in a protein-containing complex. Experimental data for this gene in peripheral blood mononuclear cells (from study GSE131504) shows a log2 fold change of -2.313 and an adjusted p-value of 0.001404. Which disease is associated with this gene as a ... | urinary bladder neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03472","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which is located in a protein-containing complex. Experimental data... | |
medium_hidden_intermediate_03474 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in actin cytoskeleton organization. One of these genes shows a log2 fold change of approximately 1.85 and an adjusted p-value of approximately 0.022 in bronchial epithelial cells. Which disease is associated with this sp... | breast cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03474","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in actin cytoskeleton or... | |
medium_hidden_intermediate_03475 | DNMT3A interacts with a specific protein that enables protein binding. Evidence indicates that this protein is an H3-K9 histone methyltransferase that binds Dnmt3a via its PHD-like motif, interacting both in vitro and in vivo. Which cell type is this protein enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03475","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"DNMT3A interacts with a specific protein that enables protein binding. Evidence indicates that this protein is an H3-K9 hist... | |
medium_hidden_intermediate_03476 | Rhinovirus A upregulates a gene that enables sequence-specific double-stranded DNA binding. Evidence for this gene reports a log2 fold change of 1.106 and an adjusted p-value of 0.0002402. Which cell type is this gene enriched in? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03476","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A upregulates a gene that enables sequence-specific double-stranded DNA binding. Evidence for this gene reports a... | |
medium_hidden_intermediate_03477 | Two genes are structurally linked to Cardiovirus A via an 'upregulates' relationship and to Naive B cells via an 'enriched in' relationship. One of these genes has a reported log2 fold change of 1.722 and an adjusted p-value of 0.03486 in a specific study. Which protein is encoded by the gene matching these statistical... | Protein TMEPAI | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03477","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Cardiovirus A via an 'upregulates' relationship and to Naive B cells via an 'enriched i... | |
medium_hidden_intermediate_03478 | A gene serves as a marker for mitotic fetal germ cells and is associated with autism spectrum disorder. Evidence indicates that globally, 5-hydroxymethylcytosine (5-hmC) was significantly increased in the autism cerebellum, accompanied by increases in the expression of de novo methyltransferases DNMT3A and DNMT3B, as w... | atherosclerosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03478","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for mitotic fetal germ cells and is associated with autism spectrum disorder. Evidence indicates t... | |
medium_hidden_intermediate_03481 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene that participates in lipid metabolism. This gene exhibited a log2 fold change of approximately 1.32 and an adjusted p-value of approximately 0.0068. Which biological process is this gene involved in? | ceramide biosynthetic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03481","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene that parti... | |
medium_hidden_intermediate_03482 | Two genes are downregulated by Pegivirus C and participate in SARS-CoV-2 infection. One of these genes exhibits a log2 fold change of -2.378 and an adjusted p-value of 0.006992 in peripheral blood mononuclear cells. Which disease is associated with this specific gene? | kidney cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03482","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and participate in SARS-CoV-2 infection. One of these genes exhibits a log2 fold ... | |
medium_hidden_intermediate_03484 | Two genes are upregulated by Vaccinia virus and interact with MYC. One of these genes shows a log2 fold change of 1.239 and an adjusted p-value of 1.465e-09 in cervical adenocarcinoma cell lines. Which cell type is enriched for this specific gene? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03484","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and interact with MYC. One of these genes shows a log2 fold change of 1.239 and ... | |
medium_hidden_intermediate_03485 | Hepacivirus C upregulates a gene that is involved in the negative regulation of transcription by RNA polymerase II. Evidence for one such gene reports a log2 fold change of 1.130 and an adjusted p-value of 0.01684. Which disease is associated with this gene as a biomarker? | prostate cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03485","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in the negative regulation of transcription by RNA polymerase II. Evidence... | |
medium_hidden_intermediate_03486 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and serves as a biomarker for depressive disorder. Evidence for this gene reports a log2 fold change of -1.897 and an adjusted p-value of 0.0199. Which protein is encoded by this gene? | Early growth response protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03486","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and serves as a biomarker for depressive di... | |
medium_hidden_intermediate_03489 | A gene is upregulated by Zika virus and associated with alcoholic liver cirrhosis. Experimental data for this gene reports a log2 fold change of approximately 1.22 and an adjusted p-value of 0.0357. Which protein is encoded by this gene? | Sulfotransferase 1E1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03489","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Zika virus and associated with alcoholic liver cirrhosis. Experimental data for this gene reports a... | |
medium_hidden_intermediate_03491 | A gene is downregulated by Measles morbillivirus and participates in Developmental Biology. Experimental data for this gene in pleural mesothelioma cells (study GSE117668) reports a log2 fold change of approximately -1.057 and an adjusted p-value of 0.0001916. Which disease is associated with this gene as a biomarker? | glomerulonephritis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03491","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Measles morbillivirus and participates in Developmental Biology. Experimental data for this gene ... | |
medium_hidden_intermediate_03493 | A bone neoplasm is localized to an anatomical structure that connects to the humerus. Evidence indicates that this structure, commonly known as the shoulder joint, is a multiaxial synovial ball-and-socket joint involving articulation between the glenoid fossa of the scapula and the head of the humerus. Which anatomical... | scapulocoracoid | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03493","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A bone neoplasm is localized to an anatomical structure that connects to the humerus. Evidence indicates that this structure... | |
medium_hidden_intermediate_03494 | In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection was found to upregulate a specific gene that is involved in substantia nigra development. This gene exhibited a log2 fold change of approximately 1.694 and an adjusted p-value of 1.801e-08. Which protein is encoded by t... | Synaptogyrin-3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03494","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection was found to upregulate... | |
medium_hidden_intermediate_03495 | In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and its product binds to UBC. This gene exhibits a log2 fold change of approximately 1.082 and an adjusted p-value of 0.03844. Which protein is encoded by this gene? | Protein jagged-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03495","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and its product binds to UBC. Thi... | |
medium_hidden_intermediate_03496 | A gene serves as a marker for stem cells and is localized to the endoplasmic reticulum membrane. Evidence concerning one such entity reports: 'In the present study, full-length human 17HSD type 2 was localized in the endoplasmic reticulum using a double immunofluorescence labeling technique.' Which disease is connected... | endometriosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03496","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for stem cells and is localized to the endoplasmic reticulum membrane. Evidence concerning one suc... | |
medium_hidden_intermediate_03498 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the positive regulation of DNA repair. One of these genes exhibits a log2 fold change of 1.451 and an adjusted p-value of 0.006622 in a specific study. Which cellular component is the location of this specific gene? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03498","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the positive regulati... | |
medium_hidden_intermediate_03499 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that interacts with USP10. Evidence for one such gene reports a log2 fold change of -1.043 and an adjusted p-value of 0.04975. Which biological process is that gene involved in? | Wnt signaling pathway, planar cell polarity pathway | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03499","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that interacts with USP10. Evidence for one such ... | |
medium_hidden_intermediate_03500 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to upregulate a specific gene, which in turn participates in signal transduction. This gene exhibited a log2 fold change of approximately 1.03 and an adjusted p-value of 0.0157. Which biological process is this gene involved... | clathrin-dependent endocytosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03500","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_03501 | In a study of the sclera (GSE164073), Severe acute respiratory syndrome-related coronavirus was found to upregulate a gene that is involved in the regulation of cell shape. One such gene exhibited a log2 fold change of 1.214 and an adjusted p-value of 0.003291. Which protein is encoded by this specific gene? | TBCC domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03501","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of the sclera (GSE164073), Severe acute respiratory syndrome-related coronavirus was found to upregulate a gene t... | |
medium_hidden_intermediate_03504 | Rift Valley fever phlebovirus infection leads to the upregulation of certain genes that are enriched in natural killer cells. One such gene exhibits a log2 fold change of 4.616 and an adjusted p-value of 0.04956 in SAEC cells (study GSE102481). Which protein is encoded by this specific gene? | Signal-transducing adaptor protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03504","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rift Valley fever phlebovirus infection leads to the upregulation of certain genes that are enriched in natural killer cells... | |
medium_hidden_intermediate_03505 | In the study GSE131840, Measles morbillivirus upregulates a gene that subsequently interacts with ANLN. One such gene exhibits a log2 fold change of approximately 1.06 and an adjusted p-value of 0.02052. Which protein is encoded by this specific gene? | ELKS/Rab6-interacting/CAST family member 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03505","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In the study GSE131840, Measles morbillivirus upregulates a gene that subsequently interacts with ANLN. One such gene exhibi... | |
medium_hidden_intermediate_03507 | In a study of non-small cell lung adenocarcinoma cell lines (GSE106279), Influenza A virus infection leads to the downregulation of certain genes that are enriched in basophils. One such gene exhibits a log2 fold change of approximately -1.408 and an adjusted p-value of 0.008169. Which cellular component is this specif... | membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03507","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE106279), Influenza A virus infection leads to the downregula... | |
medium_hidden_intermediate_03508 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in Vesicle-mediated transport. One of these genes exhibits a log2 fold change of -1.473 and an adjusted p-value of 0.03721. Which protein is encoded by this specific gene? | Ras-related protein Rab-7b | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03508","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in Vesicle-mediated tra... | |
medium_hidden_intermediate_03511 | Zika virus downregulates a gene involved in the AMP biosynthetic process. In a study of glioma stem cells (GSE114907), one such gene exhibits a log2 fold change of approximately -1.146 and an adjusted p-value of 0.01254. Which cellular component is this gene located in? | protein-containing complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03511","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene involved in the AMP biosynthetic process. In a study of glioma stem cells (GSE114907), one s... | |
medium_hidden_intermediate_03512 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in PI3K/AKT Signaling in Cancer. Evidence for this gene reports a log2 fold change of 3.132 and an adjusted p-value of 0.014. Which protein is encoded by this gene? | Phosphoinositide 3-kinase regulatory subunit 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03512","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in PI3K/AKT Signaling in Cancer. ... | |
medium_hidden_intermediate_03514 | Two genes serve as markers for B cells and are associated with sarcoma. One of these genes is discussed in a 2008 study with the statement: 'In contrast, no data are available on its expression on FDC sarcoma (FDC-S) cells.' What is the cellular location of this specific gene? | extracellular region | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03514","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes serve as markers for B cells and are associated with sarcoma. One of these genes is discussed in a 2008 study with... | |
medium_hidden_intermediate_03515 | A gene is downregulated by Cardiovirus A and is located in the spindle. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of -1.633 and an adjusted p-value of 0.009313. Which disease is associated with this gene through genomic alterations? | atherosclerosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03515","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Cardiovirus A and is located in the spindle. Experimental data for this gene in a cervical adenoc... | |
medium_hidden_intermediate_03516 | In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection was found to downregulate a specific gene that is enriched in natural killer cells. This gene exhibited a log2 fold change of approximately -1.064 and an adjusted p-value of 1.25e-11. Which protein is encoded by this ge... | Protein disulfide isomerase CRELD2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03516","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection was found to downregula... | |
medium_hidden_intermediate_03517 | Pegivirus C is reported to downregulate a specific gene that is involved in the negative regulation of DNA-templated transcription. Experimental data for this gene indicates a log2 fold change of -2.047 and an adjusted p-value of 0.0004336. In which cell type is this gene enriched? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03517","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene that is involved in the negative regulation of DNA-templated transcr... | |
medium_hidden_intermediate_03518 | Rhinovirus A upregulates a specific gene that is enriched in conventional dendritic cells. Evidence for this gene reports a log2 fold change of 1.701 and an adjusted p-value of 0.02436. Which disease is associated with this gene as a biomarker? | rheumatoid arthritis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03518","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A upregulates a specific gene that is enriched in conventional dendritic cells. Evidence for this gene reports a ... | |
medium_hidden_intermediate_03519 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is located in the extracellular matrix. Evidence for one such gene reports a log2 fold change of -1.169 and an adjusted p-value of 1.5e-07. Which protein is encoded by that gene? | Inhibin beta E chain | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03519","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is located in the extracellular matrix. Evid... | |
medium_hidden_intermediate_03520 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and binds to NCBP1. Evidence for this gene reports a log2 fold change of approximately 1.062 and an adjusted p-value of 0.01624. Which biological process is this gene involved in? | mRNA splicing, via spliceosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03520","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and binds to NCBP1. Evidence for this gene re... | |
medium_hidden_intermediate_03521 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with lung carcinoma. One of these genes exhibits a log2 fold change of approximately 1.175 and an adjusted p-value of 0.03644 in bronchial epithelial cells. Which biological process is this specific gene involved in? | L-methionine salvage from methylthioadenosine | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03521","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with lung carcinoma. O... | |
medium_hidden_intermediate_03522 | Zika virus downregulates a specific gene, which in turn interacts with ZYX. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -1.017 and an adjusted p-value of 0.03313. Which disease is associated with this gene? | acute myeloid leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03522","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with ZYX. Experimental data for this gene in glioma stem c... | |
medium_hidden_intermediate_03524 | Rhinovirus A infection leads to the downregulation of certain genes involved in cell-cell junction organization. One such gene, identified in cytotoxic T-lymphocytes from study GSE106475, exhibits a log2 fold change of approximately -1.636 and an adjusted p-value of 0.01715. Which protein is encoded by this specific ge... | Claudin-23 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03524","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection leads to the downregulation of certain genes involved in cell-cell junction organization. One such ge... | |
medium_hidden_intermediate_03525 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via downregulation and to alveolar rhabdomyosarcoma via association. One of these genes exhibits a log2 fold change of approximately -1.56 and an adjusted p-value of 0.02279 in choroid plexus epithelium. Which biological process is this speci... | melanosome organization | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03525","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via downregulation and to alveolar rhabdomyosa... | |
medium_hidden_intermediate_03526 | Two genes are upregulated by Vaccinia virus and participate in the synthesis of phosphatidylethanolamine (PE). One of these genes exhibits a log2 fold change of approximately 1.49 and an adjusted p-value of approximately 0.00017 in cervical adenocarcinoma cell lines. Which disease is associated with this specific gene? | spastic paraplegia 82, autosomal recessive | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03526","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and participate in the synthesis of phosphatidylethanolamine (PE). One of these ... | |
medium_hidden_intermediate_03527 | Cyproheptadine and Alimemazine are linked via a shared interacting drug. Clinical evidence regarding this intermediate drug states: 'The symptoms and signs were resolved within 3 days following hydration, sedation, and cyproheptadine.' Which disease is this intermediate drug indicated for? | bipolar I disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03527","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cyproheptadine and Alimemazine are linked via a shared interacting drug. Clinical evidence regarding this intermediate drug ... | |
medium_hidden_intermediate_03528 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to chondrosarcoma via an association relationship. One of these genes was reported in a study of bronchial epithelial cells (GSE147507) with a log2 fold change of approximately 2.31 and an adjusted p-value... | Elafin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03528","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to chondr... | |
medium_hidden_intermediate_03529 | HSP90AA1 interacts with a protein that is enriched in natural killer cells. Evidence regarding this protein states: 'The phosphorylation of Hsp90 and Hsp70 prevents binding to CHIP and thus enhances binding to a chaperone co-chaperone.' Which protein is encoded by the gene corresponding to this entity? | Homeodomain-only protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03529","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"HSP90AA1 interacts with a protein that is enriched in natural killer cells. Evidence regarding this protein states: 'The pho... | |
medium_hidden_intermediate_03530 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the positive regulation of the Notch signaling pathway. Evidence for this gene reports a log2 fold change of 1.574 and an adjusted p-value of 0.007185. Which cell type is this gene enriched in? | naive thymus-derived CD8-positive, alpha-beta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03530","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the positive regulation of... | |
medium_hidden_intermediate_03531 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate specific genes involved in Rab regulation of trafficking. One such gene exhibited a log2 fold change of approximately 2.725 and an adjusted p-value of 8.808e-08. Which protein is encoded by this specific gene? | Protein DENND6B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03531","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate specific genes invo... | |
medium_hidden_intermediate_03533 | Rhinovirus A infection leads to the downregulation of specific genes, some of which encode proteins located in the trans-Golgi network. In a study of cytotoxic T-lymphocytes (GSE106475), one such gene exhibited a log2 fold change of -1.956 and an adjusted p-value of 0.0284. Which protein is encoded by this gene? | Membrane-spanning 4-domains subfamily A member 6A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03533","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection leads to the downregulation of specific genes, some of which encode proteins located in the trans-Gol... | |
medium_hidden_intermediate_03534 | TRIM21 and RIPK1 are linked via an intermediate protein that interacts with both. One such intermediate is supported by evidence stating: 'The mammalian 2-hybrid assay confirmed the interaction between full-length 52Ro and UnpEL.' Which protein is encoded by the gene corresponding to this intermediate entity? | Ubiquitin carboxyl-terminal hydrolase 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03534","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"TRIM21 and RIPK1 are linked via an intermediate protein that interacts with both. One such intermediate is supported by evid... | |
medium_hidden_intermediate_03535 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes that subsequently interact with NGRN. One such gene exhibited a log2 fold change of 2.269 and an adjusted p-value of 3.881e-06. Which protein is encoded by this specific gene? | Mitochondrial mRNA pseudouridine synthase RPUSD3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03535","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes ... | |
medium_hidden_intermediate_03536 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in SARS-CoV Infections. One of these genes has an associated study reporting a log2 fold change of approximately 1.077 and an adjusted p-value of approximately 3.958e-06. Which protein is encoded by this specific gene? | Protein transport protein Sec24A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03536","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in SARS-CoV Infections. O... | |
medium_hidden_intermediate_03537 | Human immunodeficiency virus 1 upregulates a gene that is located on the cell surface. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of 4.392 and an adjusted p-value of 0.0004411. Which protein does this gene product bind to? | ADGRB1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03537","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is located on the cell surface. In a study of macrophages (GSE108897)... | |
medium_hidden_intermediate_03539 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Evidence for one such gene reports a log2 fold change of 4.429 and an adjusted p-value of 0.01027. Which protein is encoded by that gene? | F-box/LRR-repeat protein 14 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03539","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the SCF-dependent proteasomal u... | |
medium_hidden_intermediate_03540 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and enables FK506 binding. This specific gene exhibits a log2 fold change of 2.275 and an adjusted p-value of 6.011e-13. Which protein is encoded by this gene? | Peptidyl-prolyl cis-trans isomerase FKBP3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03540","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and enables FK506 bindi... | |
medium_hidden_intermediate_03541 | The protein INS is involved in a biological process that is a subtype of the negative regulation of lipid metabolic process. One such process is defined as any process that stops, prevents, or reduces the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids. Which biolo... | lipid catabolic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03541","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"The protein INS is involved in a biological process that is a subtype of the negative regulation of lipid metabolic process.... | |
medium_hidden_intermediate_03542 | Rhinovirus A downregulates a gene that is associated with melanoma. Evidence for this gene in cytotoxic T-lymphocytes (study GSE106475) reports a log2 fold change of -1.361 and an adjusted p-value of 6.881e-05. Which protein is encoded by this gene? | Ribonuclease SLFN12 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03542","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A downregulates a gene that is associated with melanoma. Evidence for this gene in cytotoxic T-lymphocytes (study... | |
medium_hidden_intermediate_03543 | Hepacivirus C upregulates a gene that participates in Developmental Cell Lineages. Evidence for one such gene reports a log2 fold change of 3.564 and an adjusted p-value of 0.0415. Which protein is encoded by that gene? | Suprabasin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03543","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in Developmental Cell Lineages. Evidence for one such gene reports a log2... | |
medium_hidden_intermediate_03544 | Rhinovirus A infection is associated with the upregulation of specific genes that are enriched in eosinophils. One such gene exhibits a log2 fold change of approximately 1.808 and an adjusted p-value of 0.01535 in cytotoxic T-lymphocytes (based on study GSE106475). What molecular function is enabled by this specific ge... | G protein-coupled receptor activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03544","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection is associated with the upregulation of specific genes that are enriched in eosinophils. One such gene... | |
medium_hidden_intermediate_03545 | Zaire ebolavirus upregulates a gene that is involved in the defense response. Transcriptomic data from a study (GSE100839) indicates that this specific gene exhibits a log2 fold change of approximately 2.15 and an adjusted p-value of approximately 1.89e-05. In which cell type is this gene enriched? | memory B cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03545","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus upregulates a gene that is involved in the defense response. Transcriptomic data from a study (GSE100839) i... | |
medium_hidden_intermediate_03547 | Two genes are downregulated by Pegivirus C and interact with RAB11A. One of these genes exhibits a log2 fold change of approximately -1.90 and an adjusted p-value of 0.0054 in peripheral blood mononuclear cells from study GSE131504. Which protein is encoded by this specific gene? | SCY1-like protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03547","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and interact with RAB11A. One of these genes exhibits a log2 fold change of appro... | |
medium_hidden_intermediate_03548 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated by the virus and its product binds to EIF4E. This gene exhibits a log2 fold change of 1.334 and an adjusted p-value of 0.007466. Which protein is encoded by this gene? | CCR4-NOT transcription complex subunit 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03548","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated by the virus a... | |
medium_hidden_intermediate_03549 | Human immunodeficiency virus 1 upregulates a gene that is involved in early endosome to late endosome transport. Evidence for this gene in natural killer cells (study GSE125686) reports a log2 fold change of approximately 1.44 and an adjusted p-value of approximately 0.0116. Which protein is encoded by this gene? | Sorting nexin-16 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03549","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is involved in early endosome to late endosome transport. Evidence fo... | |
medium_hidden_intermediate_03550 | Hepacivirus C upregulates a gene that is involved in the positive regulation of DNA-templated transcription. Evidence for one such gene reports a log2 fold change of 1.332 and an adjusted p-value of 0.03673. Which disease is associated with this gene as a biomarker? | breast cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03550","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in the positive regulation of DNA-templated transcription. Evidence for on... | |
medium_hidden_intermediate_03552 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in the synthesis of DNA. Evidence for this gene reports a log2 fold change of -1.562 and an adjusted p-value of 0.008483. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03552","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in the synthesis of DNA. E... | |
medium_hidden_intermediate_03553 | Human immunodeficiency virus 1 upregulates a gene that participates in the inhibition of DNA recombination at the telomere. Experimental data for this gene reports a log2 fold change of approximately 1.009 and an adjusted p-value of 6.076e-05. Which protein is encoded by this gene? | Histone H2A.J | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03553","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in the inhibition of DNA recombination at the telomere. ... | |
medium_hidden_intermediate_03554 | Two genes are linked to Influenza A virus via upregulation and to prostate cancer via biomarker association. One of these genes has a reported log2 fold change of 1.064 and an adjusted p-value of 0.04019 in a specific study. Which protein is encoded by the gene matching these statistical values? | Phorbol-12-myristate-13-acetate-induced protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03554","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Influenza A virus via upregulation and to prostate cancer via biomarker association. One of these ge... | |
medium_hidden_intermediate_03555 | Two distinct proteins are known to interact with both FGFR1 and SQSTM1. One of these proteins is characterized by evidence showing that it binds directly to and ubiquitylates activated FGFR1, primarily via its WW3 domain interacting with a novel non-canonical sequence (non-PY motif) on FGFR1. Which gene encodes this sp... | E3 ubiquitin-protein ligase NEDD4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03555","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct proteins are known to interact with both FGFR1 and SQSTM1. One of these proteins is characterized by evidence s... | |
medium_hidden_intermediate_03556 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in peptide hormone metabolism. Evidence for one such gene reports a log2 fold change of -1.155 and an adjusted p-value of 5.183e-06. Which protein is encoded by that gene? | Glutamyl aminopeptidase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03556","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in peptide hormone metabolism. ... | |
medium_hidden_intermediate_03557 | Cardiovirus A upregulates a gene that is located in the extracellular region. Evidence for one such gene reports a log2 fold change of 1.306 and an adjusted p-value of 0.01337. Which protein is encoded by that gene? | EMILIN-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03557","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A upregulates a gene that is located in the extracellular region. Evidence for one such gene reports a log2 fold... | |
medium_hidden_intermediate_03558 | Hepacivirus C upregulates a gene that is located in the cytosol. Evidence for this gene reports a log2 fold change of 1.610 and an adjusted p-value of 0.02352. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03558","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is located in the cytosol. Evidence for this gene reports a log2 fold change of 1.610 ... | |
medium_hidden_intermediate_03559 | Human immunodeficiency virus 1 downregulates a gene that is associated with carcinoma. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately -1.60 and an adjusted p-value of 0.008696. Which protein is encoded by this gene? | Jupiter microtubule associated homolog 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03559","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is associated with carcinoma. In a study of macrophages (GSE108897)... | |
medium_hidden_intermediate_03561 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to TNF signaling via a participation relationship. One of these genes is associated with experimental data showing a log2 fold change of approximately 1.57 and an adjusted p-value of 0.0066. W... | Spermatogenesis-associated protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03561","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship ... | |
medium_hidden_intermediate_03562 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the positive regulation of canonical NF-kappaB signal transduction. One of these genes exhibits a log2 fold change of approximately -1.03 and an adjusted p-value of approximately 0.0045 in a specific study. Which ce... | classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03562","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the positive regula... | |
medium_hidden_intermediate_03565 | Two genes are upregulated by Influenza A virus and participate in the response to elevated platelet cytosolic Ca2+. One of these genes shows a log2 fold change of 1.582 and an adjusted p-value of 6.943e-06 in bronchial epithelial cells. Which disease is associated with genomic alterations in this specific gene? | leukocyte adhesion deficiency 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03565","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Influenza A virus and participate in the response to elevated platelet cytosolic Ca2+. One of t... | |
medium_hidden_intermediate_03566 | Human betaherpesvirus 5 upregulates a gene that enables identical protein binding. In a specific study, this gene exhibited a log2 fold change of approximately 2.82 and an adjusted p-value of approximately 0.0347. Which cellular component is this gene located in? | extrinsic component of cytoplasmic side of plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03566","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that enables identical protein binding. In a specific study, this gene exhibited ... | |
medium_hidden_intermediate_03567 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the Cytochrome P450 - arranged by substrate type pathway. One of these genes exhibits a log2 fold change of 1.258 and an adjusted p-value of 0.001533 in a specific study. Which molecular function is enabled by this spe... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03567","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the Cytochrome P450 - ... | |
medium_hidden_intermediate_03569 | Zika virus downregulates a specific gene that is associated with glioma. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -3.127 and an adjusted p-value of 0.006056. Which disease is linked to this gene as a biomarker? | glomerulonephritis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03569","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is associated with glioma. In a study of glioma stem cells (GSE114907), this g... | |
medium_hidden_intermediate_03571 | In a study of peripheral blood mononuclear cells (GSE131504), a gene is downregulated by Pegivirus C and participates in Neutrophil degranulation. This specific gene exhibits a log2 fold change of approximately -1.008 and an adjusted p-value of 0.01932. Which protein is encoded by this gene? | 28 kDa heat- and acid-stable phosphoprotein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03571","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of peripheral blood mononuclear cells (GSE131504), a gene is downregulated by Pegivirus C and participates in Neu... | |
medium_hidden_intermediate_03573 | TP53 interacts with a specific protein that is located in the nucleus. Evidence regarding this protein states: 'Our findings may explain how this protein, which possesses a NLS, exists in the nucleus and cytosol simultaneously.' Which disease is associated with this protein as a biomarker? | hepatocellular carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03573","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"TP53 interacts with a specific protein that is located in the nucleus. Evidence regarding this protein states: 'Our findings... | |
medium_hidden_intermediate_03574 | Two genes are downregulated by Human immunodeficiency virus 1 and are involved in the proteasome-mediated ubiquitin-dependent protein catabolic process. One of these genes exhibits a log2 fold change of -1.142 and an adjusted p-value of 0.003789 in macrophages. Which cellular component is the location of this specific ... | ubiquitin ligase complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03574","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Human immunodeficiency virus 1 and are involved in the proteasome-mediated ubiquitin-dependen... | |
medium_hidden_intermediate_03575 | Human immunodeficiency virus 1 downregulates a gene that participates in SLC-mediated transmembrane transport. Evidence for this gene in macrophages (study GSE108897) reports a log2 fold change of -1.574 and an adjusted p-value of 0.009225. Which biological process is this gene involved in? | very long-chain fatty acid metabolic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03575","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in SLC-mediated transmembrane transport. Evidence for ... | |
medium_hidden_intermediate_03577 | Human alphaherpesvirus 1 downregulates a gene that is located in the nucleus. In a study of monocytic leukemia cell lines (GSE114966), one such gene exhibited a log2 fold change of approximately -1.15 and an adjusted p-value of 0.0058. Which protein is encoded by this specific gene? | SNRPN upstream reading frame protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03577","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 downregulates a gene that is located in the nucleus. In a study of monocytic leukemia cell lines (G... | |
medium_hidden_intermediate_03578 | GJA5 is involved in a biological process that is a subtype of cardiac septum development. Evidence for one such process describes 'The progression of the atrial septum over time, from its initial formation to the mature structure.' Which biological process is this entity a part of? | cardiac atrium development | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03578","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"GJA5 is involved in a biological process that is a subtype of cardiac septum development. Evidence for one such process desc... | |
medium_hidden_intermediate_03579 | Human immunodeficiency virus 1 downregulates a gene that is located in the recycling endosome membrane. Evidence from a study on macrophages (GSE108897) reports that this gene has a log2 fold change of -1.235 and an adjusted p-value of 0.0009842. Which protein is encoded by this gene? | Sorting nexin-18 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03579","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is located in the recycling endosome membrane. Evidence from a stud... | |
medium_hidden_intermediate_03580 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and to Epigenetic regulation by WDR5-containing histone modifying complexes via a 'participates in' relationship. One of these genes is reported in a study (GSE151879) on cardiomyocyte cell lines... | histone acetyltransferase complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03580","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship... | |
medium_hidden_intermediate_03582 | In studies of Severe acute respiratory syndrome-related coronavirus infection, certain genes are upregulated and subsequently associated with proteinuria. One such gene exhibits a log2 fold change of approximately 1.79 and an adjusted p-value of 0.035. Which protein is encoded by this specific gene? | C-X-C chemokine receptor type 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03582","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In studies of Severe acute respiratory syndrome-related coronavirus infection, certain genes are upregulated and subsequentl... | |
medium_hidden_intermediate_03583 | In a study of Influenza A virus infection, a specific gene is downregulated by the virus and is enriched in memory B cells. Evidence for this gene reports a log2 fold change of -1.669 and an adjusted p-value of 5.227e-08. Which protein is encoded by this gene? | Protein phosphatase 1 regulatory subunit 14A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03583","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is downregulated by the virus and is enriched in memory B cells. ... | |
medium_hidden_intermediate_03586 | Severe acute respiratory syndrome-related coronavirus upregulates a specific gene that subsequently binds to TYK2. Experimental data for this gene reports a log2 fold change of 9.327 and an adjusted p-value of 0.02494. Which disease is associated with this gene as a biomarker? | hepatocellular carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03586","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a specific gene that subsequently binds to TYK2. Experimen... | |
medium_hidden_intermediate_03587 | A gene is downregulated by Primate bocaparvovirus 1 and its product is located in the extracellular exosome. Experimental evidence for this gene reports a log2 fold change of -1.487 and an adjusted p-value of 0.01812. Which protein is encoded by this gene? | Gamma-glutamylaminecyclotransferase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03587","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and its product is located in the extracellular exosome. Experimental ev... | |
medium_hidden_intermediate_03588 | Human alphaherpesvirus 1 upregulates a gene that participates in the RAC1 GTPase cycle. Evidence for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of 3.570 and an adjusted p-value of 0.006188. Which protein is encoded by this gene? | Ras GTPase-activating-like protein IQGAP3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03588","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that participates in the RAC1 GTPase cycle. Evidence for this gene in a monocyti... | |
medium_hidden_intermediate_03590 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the RAC1 GTPase cycle. Evidence for one such gene reports a log2 fold change of 1.049 and an adjusted p-value of 0.0008212. Which protein is encoded by that gene? | WAS/WASL-interacting protein family member 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03590","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the RAC1 GTPase cycle. Evidenc... | |
medium_hidden_intermediate_03591 | Human immunodeficiency virus 1 downregulates a gene that is located in the Golgi membrane. Evidence from a study on macrophages (GSE108897) reports that this gene has a log2 fold change of approximately -1.052 and an adjusted p-value of 0.03652. Which protein is encoded by this gene? | MICOS complex subunit MIC26 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03591","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is located in the Golgi membrane. Evidence from a study on macropha... | |
medium_hidden_intermediate_03592 | A gene is upregulated by Measles morbillivirus and associated with adenoviridae infectious disease. Evidence for this gene reports a log2 fold change of 3.218 and an adjusted p-value of 0.01966. Which disease is causally linked to this gene? | megacolon | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03592","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and associated with adenoviridae infectious disease. Evidence for this gene r... | |
medium_hidden_intermediate_03594 | Two genes are structurally linked to Pegivirus C via a downregulation relationship and to the cardiolipin biosynthetic process via an involvement relationship. One of these genes exhibits a log2 fold change of -1.869 and an adjusted p-value of 0.01059 in peripheral blood mononuclear cells (study GSE131504). Which disea... | combined oxidative phosphorylation deficiency 56 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03594","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Pegivirus C via a downregulation relationship and to the cardiolipin biosynthetic proce... | |
medium_hidden_intermediate_03595 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes involved in the proteasome-mediated ubiquitin-dependent protein catabolic process. One such gene exhibited a log2 fold change of 1.223 and an adjusted p-value of 2.192e-05. What molecular functio... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03595","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes... | |
medium_hidden_intermediate_03597 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the process 'PI5P Regulates TP53 Acetylation'. Evidence for one such gene reports a log2 fold change of 1.029 and an adjusted p-value of 0.02491. Which gene interacts with this specific upregulated gene? | SPOP | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03597","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the process 'PI5P Regulates TP... | |
medium_hidden_intermediate_03598 | Hepacivirus C downregulates a gene that is located on the cell surface. Evidence for one such gene reports a log2 fold change of -1.323 and an adjusted p-value of 0.003522. Which biological process is this gene involved in? | positive regulation of Rho protein signal transduction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03598","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a gene that is located on the cell surface. Evidence for one such gene reports a log2 fold chang... | |
medium_hidden_intermediate_03600 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is located in the mitochondrial inner membrane. Evidence for this gene reports a log2 fold change of -1.128 and an adjusted p-value of 0.0004475. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03600","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is located in the mitochondrial inner m... | |
medium_hidden_intermediate_03601 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a specific gene, which in turn participates in protein localization. This gene exhibits a log2 fold change of approximately 1.36 and an adjusted p-value of approximately 0.0436. Which protein is encoded by this gene? | Peroxisomal coenzyme A diphosphatase NUDT7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03601","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a specific gene, which in turn participate... | |
medium_hidden_intermediate_03602 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in turn interacts with LIN7B. This gene exhibited a log2 fold change of -2.443 and an adjusted p-value of 0.006912. Which protein is encoded by this gene? | MAGUK p55 subfamily member 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03602","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in tu... | |
medium_hidden_intermediate_03603 | Human immunodeficiency virus 1 downregulates a gene that interacts with CCNF. Experimental data for this gene in macrophages (study GSE108897) shows a log2 fold change of -2.019 and an adjusted p-value of 0.002316. Which biological process is this gene involved in? | positive regulation of focal adhesion assembly | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03603","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that interacts with CCNF. Experimental data for this gene in macrophages... |
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