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medium_hidden_intermediate_03604 | Hepacivirus C downregulates a specific gene, which in turn interacts with CNOT7. Experimental data for this gene reports a log2 fold change of approximately -1.052 and an adjusted p-value of 0.02748. Which cellular component is this gene located in? | CCR4-NOT complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03604","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a specific gene, which in turn interacts with CNOT7. Experimental data for this gene reports a l... | |
medium_hidden_intermediate_03606 | Two genes are upregulated by Human alphaherpesvirus 3 and associated with colon carcinoma. One of these genes exhibits a log2 fold change of 1.077 and an adjusted p-value of 9.416e-05 in a specific study. Which cell type is enriched for this specific gene? | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03606","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human alphaherpesvirus 3 and associated with colon carcinoma. One of these genes exhibits a log... | |
medium_hidden_intermediate_03607 | Enterovirus A is known to downregulate certain genes that are located in the nucleus. One such gene exhibits a log2 fold change of -1.313 and an adjusted p-value of 0.00481 in rhabdomyosarcoma cells. Which disease is associated with genomic alterations in this specific gene? | post-traumatic stress disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03607","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is known to downregulate certain genes that are located in the nucleus. One such gene exhibits a log2 fold cha... | |
medium_hidden_intermediate_03608 | In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection leads to the upregulation of a specific gene, which in turn interacts with BRCA1. The expression data for this intermediate gene shows a log2 fold change of approximately 1.371 and an adjusted p-value of 4.042e-05. Whic... | Protein CIP2A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03608","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection leads to the upregulati... | |
medium_hidden_intermediate_03609 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the downregulation of a specific gene that enables phospholipase binding. This gene exhibits a log2 fold change of approximately -2.79 and an adjusted p-value of 0.0052. Which protein interacts with this downregulated gene? | TRAF6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03609","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the downregulation of a specific g... | |
medium_hidden_intermediate_03611 | Zika virus downregulates a gene that is located in the axoneme. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -2.71 and an adjusted p-value of approximately 0.0039. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03611","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in the axoneme. In a study of glioma stem cells (GSE114907), this gene exhib... | |
medium_hidden_intermediate_03613 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the regulation of RNA splicing. Evidence for one such gene reports a log2 fold change of 1.056 and an adjusted p-value of 0.006314. Which protein is encoded by that gene? | N(6)-adenine-specific methyltransferase METTL4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03613","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the regulation of RNA splicing.... | |
medium_hidden_intermediate_03616 | Two genes are structurally linked to Human immunodeficiency virus 1 via an 'upregulates' relationship and to the negative regulation of apoptotic process via an 'involved in' relationship. One of these genes is associated with a log2 fold change of approximately 2.40 and an adjusted p-value of approximately 0.00067 in ... | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03616","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via an 'upregulates' relationship and to the negative re... | |
medium_hidden_intermediate_03618 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by the virus and is involved in the negative regulation of the apoptotic process. This gene exhibits a log2 fold change of approximately 2.098 and an adjusted p-value of 0.001673. Which protein does th... | BTRC | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03618","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by th... | |
medium_hidden_intermediate_03619 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the positive regulation of stress fiber assembly. Evidence for this gene reports a log2 fold change of -1.269 and an adjusted p-value of 0.0199. Which cell type is this gene enriched in? | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03619","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the positive regulation ... | |
medium_hidden_intermediate_03620 | CUL3 interacts with a specific protein that is involved in protein ubiquitination. Evidence indicates that the complex formed by this protein and CUL3 acts as an E3 ubiquitin ligase targeting hypophosphorylated 4E-BP1. Which protein is encoded by the gene corresponding to this interacting partner? | Kelch-like protein 25 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03620","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"CUL3 interacts with a specific protein that is involved in protein ubiquitination. Evidence indicates that the complex forme... | |
medium_hidden_intermediate_03621 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated by the virus and its product binds to YBX1. Evidence for this gene reports a log2 fold change of -1.141 and an adjusted p-value of 0.0004648. Which protein is encoded by this gene? | Cleavage and polyadenylation specificity factor subunit 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03621","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated by the virus... | |
medium_hidden_intermediate_03623 | A specific protein interacts with PTCH1 and enables protein binding. Mechanistically, this protein interacts with PTCH1 and inhibits the degradation of the SHH/PTCH1 complex through the recruitment of the deubiquitinating enzyme ATXN3. Which cellular component is this protein located in? | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03623","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A specific protein interacts with PTCH1 and enables protein binding. Mechanistically, this protein interacts with PTCH1 and ... | |
medium_hidden_intermediate_03624 | In the context of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and participates in Scavenging by Class A Receptors. Experimental data for this gene reports a log2 fold change of approximately 1.507 and an adjusted p-value of 0.007032. Which protein is encoded by this g... | Secretoglobin family 3A member 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03624","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In the context of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and partic... | |
medium_hidden_intermediate_03625 | Hepacivirus C upregulates a gene that participates in RNA Polymerase II Transcription. Evidence for this gene reports a log2 fold change of 1.777 and an adjusted p-value of 0.04692. Which protein is encoded by this gene? | Histone H2B type 1-D | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03625","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in RNA Polymerase II Transcription. Evidence for this gene reports a log2... | |
medium_hidden_intermediate_03628 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in the response to elevated platelet cytosolic Ca2+. Evidence for this gene reports a log2 fold change of -2.787 and an adjusted p-value of 0.003059. Which disease is associated with this gene as a biomarker? | hepatocellular carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03628","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in the response to elevate... | |
medium_hidden_intermediate_03629 | In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and enables small GTPase binding. This specific gene exhibits a log2 fold change of approximately -1.46 and an adjusted p-value of 0.0304. Which disease is associated with this gene as a biomarker? | dementia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03629","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and enab... | |
medium_hidden_intermediate_03630 | Human betaherpesvirus 5 is known to upregulate certain genes that are enriched in plasmacytoid dendritic cells. One such gene exhibits a log2 fold change of 1.058 and an adjusted p-value of 0.001383 in a specific study. Which disease is associated with this gene as a biomarker? | Huntington disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03630","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is known to upregulate certain genes that are enriched in plasmacytoid dendritic cells. One such gen... | |
medium_hidden_intermediate_03631 | Human alphaherpesvirus 1 upregulates a specific gene product that is subsequently found in extracellular exosomes. Experimental data from study GSE114966 indicates that this entity exhibits a log2 fold change of 1.632 and an adjusted p-value of 0.03816 in a monocytic leukemia cell line. Which cell type is this entity e... | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03631","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a specific gene product that is subsequently found in extracellular exosomes. Experimen... | |
medium_hidden_intermediate_03633 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the spindle pole. Evidence for this gene reports a log2 fold change of 1.903 and an adjusted p-value of 0.008029. Which protein is encoded by this gene? | Centrosomal protein of 95 kDa | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03633","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the spindle pole. Evidence for t... | |
medium_hidden_intermediate_03634 | Zika virus downregulates a gene that participates in the synthesis of bile acids and bile salts. In a study of glioma stem cells (GSE114907), one such gene showed a log2 fold change of approximately -1.02 and an adjusted p-value of 0.0175. Which protein is encoded by this specific gene? | Oxysterol-binding protein-related protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03634","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in the synthesis of bile acids and bile salts. In a study of glioma stem c... | |
medium_hidden_intermediate_03635 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is enriched in Gamma delta(γδ) T cells. Evidence for this gene reports a log2 fold change of -1.022 and an adjusted p-value of 0.0003576. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03635","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is enriched in Gamma delta(γδ) T cells.... | |
medium_hidden_intermediate_03637 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and to Golgi to endosome transport via an 'involved in' relationship. One of these genes is associated with experimental data showing a log2 fold change of 1.334 and an adjusted p-value of 0.0290... | WASL | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03637","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship... | |
medium_hidden_intermediate_03638 | Zika virus is reported to downregulate a specific gene, which serves as a biomarker for breast cancer. Experimental data for this gene in glioma stem cells (study GSE114907) indicates a log2 fold change of approximately -2.70 and an adjusted p-value of 0.00827. Which protein is encoded by this gene? | HCG2044780, isoform CRA_b | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03638","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus is reported to downregulate a specific gene, which serves as a biomarker for breast cancer. Experimental data for... | |
medium_hidden_intermediate_03640 | Zika virus downregulates a gene whose protein product is located in the mitochondrial matrix. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -1.527 and an adjusted p-value of 0.003916. Which protein is encoded by this specific gene? | rRNA methyltransferase 2, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03640","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene whose protein product is located in the mitochondrial matrix. In a study of glioma stem cell... | |
medium_hidden_intermediate_03641 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with CDC23. One of these genes was reported in a study (GSE151803) on liver cells with a log2 fold change of 1.284 and an adjusted p-value of 6.114e-06. Which protein is encoded by this specific gene? | F-box only protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03641","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with CDC23. One of these gen... | |
medium_hidden_intermediate_03642 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Antigen processing: Ubiquitination & Proteasome degradation. Evidence for one such gene reports a log2 fold change of 1.025 and an adjusted p-value of 6.85e-05. Which protein is encoded by that gene? | E3 ubiquitin-protein ligase TRIM9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03642","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Antigen processing: Ubiquitina... | |
medium_hidden_intermediate_03643 | Hepacivirus C upregulates a gene that enables palmitoyltransferase activity. Evidence for one such gene reports a log2 fold change of approximately 1.008 and an adjusted p-value of 0.007449. Which protein is encoded by that gene? | Palmitoyltransferase ZDHHC14 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03643","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that enables palmitoyltransferase activity. Evidence for one such gene reports a log2 fold ... | |
medium_hidden_intermediate_03646 | Hepacivirus C downregulates a specific gene, which in turn enables protein kinase binding. Experimental data for this gene reports a log2 fold change of approximately -1.05 and an adjusted p-value of approximately 0.035. Which cellular component is this gene located in? | membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03646","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a specific gene, which in turn enables protein kinase binding. Experimental data for this gene r... | |
medium_hidden_intermediate_03652 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the RHOB GTPase cycle. Evidence for this gene reports a log2 fold change of 1.029 and an adjusted p-value of 0.006892. Which cellular component is this gene located in? | glutamatergic synapse | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03652","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the RHOB GTPase cycle. Ev... | |
medium_hidden_intermediate_03653 | A gene serves as a marker for Exhausted CD4+ T cells and is enriched in neutrophils. Evidence for this gene includes a mean expression of 191.79 TPM, a z-score of 1.75, and a fold enrichment of 2.30. Which biological process is this gene involved in? | sulfide oxidation, using sulfide:quinone oxidoreductase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03653","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for Exhausted CD4+ T cells and is enriched in neutrophils. Evidence for this gene includes a mean ... | |
medium_hidden_intermediate_03656 | In a study of macrophages (GSE108897), a gene is identified as being downregulated by Human immunodeficiency virus 1 and interacting with FBXW7. This specific gene exhibits a log2 fold change of -1.313 and an adjusted p-value of 0.01897. Which protein is encoded by this gene? | RNA-binding protein 28 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03656","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified as being downregulated by Human immunodeficiency virus 1 and int... | |
medium_hidden_intermediate_03657 | In a study of bronchial epithelial cells (GSE150819), a gene is upregulated by Severe acute respiratory syndrome-related coronavirus and binds to COQ7. This specific gene exhibits a log2 fold change of approximately 1.764 and an adjusted p-value of 0.04433. Which protein is encoded by this gene? | Ubiquinone biosynthesis O-methyltransferase, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03657","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of bronchial epithelial cells (GSE150819), a gene is upregulated by Severe acute respiratory syndrome-related cor... | |
medium_hidden_intermediate_03658 | Human betaherpesvirus 5 is reported to downregulate a gene that is associated with prostate cancer. In a specific study (GSE130665) involving foreskin fibroblast cell lines, this gene exhibited a log2 fold change of -1.115 and an adjusted p-value of 2.862e-05. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03658","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that is associated with prostate cancer. In a specific study (GSE... | |
medium_hidden_intermediate_03660 | Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to Cytokine Signaling in Immune system via a 'participates in' relationship. One of these genes is associated with experimental data showing a log2 fold change of approximately -1.35 and an adjusted p-value of app... | SOCS1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03660","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to Cytokine Signa... | |
medium_hidden_intermediate_03662 | Vaccinia virus downregulates a gene that participates in chromatin organization. Evidence for one such gene reports a log2 fold change of -1.740 and an adjusted p-value of 0.04642. Which disease is associated with that gene? | lymphoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03662","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus downregulates a gene that participates in chromatin organization. Evidence for one such gene reports a log2 f... | |
medium_hidden_intermediate_03663 | Pegivirus C is reported to downregulate a specific gene, which is subsequently involved in the regulation of transcription by RNA polymerase II. Experimental data from a study on peripheral blood mononuclear cells (GSE131504) indicates that this gene exhibits a log2 fold change of approximately -2.37 and an adjusted p-... | CREB/ATF bZIP transcription factor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03663","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which is subsequently involved in the regulation of transcription b... | |
medium_hidden_intermediate_03664 | Pegivirus C is reported to downregulate a gene that participates in Hemostasis. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -1.46 and an adjusted p-value of 0.0072. Which protein interacts with this specific gene product? | PSMB7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03664","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that participates in Hemostasis. In a study of peripheral blood mononuclear c... | |
medium_hidden_intermediate_03665 | Human immunodeficiency virus 1 upregulates a gene that participates in the metabolism of carbohydrates and carbohydrate derivatives. Evidence for this gene reports a log2 fold change of 1.192 and an adjusted p-value of 0.03034. Which protein is encoded by this gene? | Syndecan-4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03665","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in the metabolism of carbohydrates and carbohydrate deri... | |
medium_hidden_intermediate_03668 | Hepacivirus C is associated with the downregulation of a gene that serves as a biomarker for colon carcinoma. Experimental data for this gene reports a log2 fold change of -1.277 and an adjusted p-value of 2.526e-06. Which protein is encoded by this gene? | Transcription factor COE3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03668","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is associated with the downregulation of a gene that serves as a biomarker for colon carcinoma. Experimental d... | |
medium_hidden_intermediate_03669 | Two genes are structurally linked to Vaccinia virus via an upregulation relationship and to DYNC1LI2 via a binding relationship. One of these genes exhibits a log2 fold change of 1.081 and an adjusted p-value of 0.006264 in the specified dataset. Which cell type is associated with this specific gene through an enrichme... | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03669","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Vaccinia virus via an upregulation relationship and to DYNC1LI2 via a binding relations... | |
medium_hidden_intermediate_03670 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by the virus and is involved in the negative regulation of gene expression. Evidence for this gene reports a log2 fold change of 1.633 and an adjusted p-value of 3.181e-05. Which protein is encoded by ... | Stanniocalcin-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03670","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by th... | |
medium_hidden_intermediate_03671 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene is downregulated and participates in the CDC42 GTPase cycle. Evidence for this gene shows a log2 fold change of -2.206 and an adjusted p-value of 0.03327. Which biological process is this gene involved in? | cell-cell adhesion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03671","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene is downregulat... | |
medium_hidden_intermediate_03673 | Zika virus downregulates a specific gene, which in turn interacts with RPA1. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -2.17 and an adjusted p-value of approximately 0.0178. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03673","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with RPA1. Experimental data for this gene in glioma stem ... | |
medium_hidden_intermediate_03674 | Two genes are structurally linked to APP via an 'interacts with' relationship and to the Immune System via a 'participates in' relationship. One of these genes is supported by evidence stating: 'We also found that hBH interacted and colocalized with APP as determined by subcellular fractionation, in vitro binding assay... | amyloidosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03674","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to APP via an 'interacts with' relationship and to the Immune System via a 'participates i... | |
medium_hidden_intermediate_03675 | Two genes are structurally linked from Pegivirus C via a downregulation relationship and subsequently to retinoblastoma via an association. One of these genes is reported in a study (GSE131504) with a log2 fold change of approximately -2.53 and an adjusted p-value of approximately 0.0153. Which cell type is this specif... | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03675","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Pegivirus C via a downregulation relationship and subsequently to retinoblastoma via ... | |
medium_hidden_intermediate_03676 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes involved in signal transduction. One such gene exhibits a log2 fold change of approximately -2.20 and an adjusted p-value of 0.0037. Which protein is encoded by this specific gene? | DNA-binding protein inhibitor ID-3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03676","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes invol... | |
medium_hidden_intermediate_03677 | Zika virus downregulates a specific gene, which in turn interacts with HSFY1. Experimental data for this intermediate gene in glioma stem cells (study GSE114907) shows a log2 fold change of -2.186 and an adjusted p-value of 0.02392. Which protein is encoded by this gene? | Protein phosphatase 1A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03677","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with HSFY1. Experimental data for this intermediate gene i... | |
medium_hidden_intermediate_03678 | Enterovirus A upregulates a gene that participates in Membrane Trafficking. Evidence for this gene in rhabdomyosarcoma cells (study GSE103308) reports a log2 fold change of 1.704 and an adjusted p-value of 0.01096. In which cell type is this gene enriched? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03678","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A upregulates a gene that participates in Membrane Trafficking. Evidence for this gene in rhabdomyosarcoma cells... | |
medium_hidden_intermediate_03679 | Identify the gene that is upregulated by Human immunodeficiency virus 1 and located on the cell surface, for which experimental data reports a log2 fold change of approximately 5.97 and an adjusted p-value of 0.014. Which disease is associated with this specific gene? | high myopia-sensorineural deafness syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03679","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Identify the gene that is upregulated by Human immunodeficiency virus 1 and located on the cell surface, for which experimen... | |
medium_hidden_intermediate_03680 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene that participates in the adaptive immune system. This gene exhibited a log2 fold change of approximately 5.39 and an adjusted p-value of 0.0128. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03680","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene that parti... | |
medium_hidden_intermediate_03681 | Zika virus downregulates a specific gene that participates in translation. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -1.599 and an adjusted p-value of 0.02042. Which biological process is this gene involved in? | mitochondrial translational termination | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03681","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in translation. In a study of glioma stem cells (GSE114907), this... | |
medium_hidden_intermediate_03682 | A specific gene serves as a marker for Natural killer T (NKT) cells and is known to interact with TP53. Experimental evidence indicates that in the presence of both p53 and MDM2, the protein product of this gene binds preferentially to MDM2, thereby interfering with p53/MDM2 complex formation and making p53 available f... | carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03682","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A specific gene serves as a marker for Natural killer T (NKT) cells and is known to interact with TP53. Experimental evidenc... | |
medium_hidden_intermediate_03683 | Two genes are linked to Enterovirus A via downregulation and to clear cell renal carcinoma via biomarker association. One of these genes exhibits a log2 fold change of -3.714 and an adjusted p-value of 0.004232 in rhabdomyosarcoma cells. Which protein is encoded by this specific gene? | Pappalysin-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03683","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Enterovirus A via downregulation and to clear cell renal carcinoma via biomarker association. One of... | |
medium_hidden_intermediate_03685 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with melanoma. One of these genes exhibits a log2 fold change of -1.547 and an adjusted p-value of 0.0007632 in a specific study. Which cell type is this gene enriched in? | peripheral blood mononuclear cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03685","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with melanoma. One o... | |
medium_hidden_intermediate_03686 | Human immunodeficiency virus 1 downregulates a gene that participates in the metabolism of carbohydrates and carbohydrate derivatives. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of -1.666 and an adjusted p-value of 0.002264. Which protein is encoded by this specific gene? | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03686","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in the metabolism of carbohydrates and carbohydrate de... | |
medium_hidden_intermediate_03687 | Zika virus downregulates a gene that participates in the metabolism of nucleotides. Transcriptomic data from glioma stem cells (study GSE114907) indicates that one such gene exhibits a log2 fold change of approximately -2.038 and an adjusted p-value of 0.00257. Which protein is encoded by this specific gene? | CTP synthase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03687","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in the metabolism of nucleotides. Transcriptomic data from glioma stem cel... | |
medium_hidden_intermediate_03691 | In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection was found to upregulate a specific gene that enables sequence-specific double-stranded DNA binding. This gene exhibited a log2 fold change of 1.613 and an adjusted p-value of 4.162e-07. Which disease is associated with ... | prostate cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03691","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection was found to upregulate... | |
medium_hidden_intermediate_03693 | Pegivirus C is reported to downregulate a gene that participates in the function of cytosolic sensors of pathogen-associated DNA. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -2.20 and an adjusted p-value of 8.57e-05. Which protein is encoded ... | Gamma-interferon-inducible protein 16 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03693","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that participates in the function of cytosolic sensors of pathogen-associated... | |
medium_hidden_intermediate_03695 | Human immunodeficiency virus 1 upregulates a gene that is involved in chaperone-mediated protein complex assembly. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of 4.006 and an adjusted p-value of 0.0032. Which protein is encoded by this gene? | Novel acetylcholine receptor chaperone | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03695","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is involved in chaperone-mediated protein complex assembly. In a stud... | |
medium_hidden_intermediate_03696 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and subsequently interacts with IRS4. Experimental data for this gene reports a log2 fold change of -1.342 and an adjusted p-value of 0.03521. Which protein is encoded by this gene? | Casein kinase I isoform gamma-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03696","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and subseque... | |
medium_hidden_intermediate_03697 | Measles morbillivirus upregulates a gene that participates in GPCR downstream signalling. Transcriptomic data for this gene shows a log2 fold change of approximately 1.49 and an adjusted p-value of 0.0004923. In which cellular component is the protein product of this gene located? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03697","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that participates in GPCR downstream signalling. Transcriptomic data for this gene ... | |
medium_hidden_intermediate_03698 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is located in the perinuclear region of the cytoplasm. Evidence for one such gene reports a log2 fold change of -2.868 and an adjusted p-value of 0.05. Which protein is encoded by that gene? | Junctional cadherin 5-associated protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03698","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is located in the perinuclear region of the ... | |
medium_hidden_intermediate_03700 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and interacts with CDC42. This specific gene exhibits a log2 fold change of approximately 1.82 and an adjusted p-value of 4.45e-08. Which disease is causally linked to this gene? | diabetes mellitus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03700","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and interacts with CDC4... | |
medium_hidden_intermediate_03701 | Hepacivirus C is reported to upregulate a gene that is associated with leukemia. One such gene exhibits a log2 fold change of approximately 1.19 and an adjusted p-value of 0.0069 in peripheral blood mononuclear cells. Which protein is encoded by this gene? | Glioma pathogenesis-related protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03701","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to upregulate a gene that is associated with leukemia. One such gene exhibits a log2 fold change o... | |
medium_hidden_intermediate_03702 | A gene serves as a marker for Paneth cells and is enriched in neutrophils. Expression data for this gene indicates a mean expression of 26.66 TPM, a z-score of 2.27, and a fold enrichment of 7.45. Which protein does this gene product interact with? | MAP3K7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03702","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for Paneth cells and is enriched in neutrophils. Expression data for this gene indicates a mean ex... | |
medium_hidden_intermediate_03706 | Zika virus downregulates a specific gene that is involved in brain development. Experimental data from glioma stem cells (study GSE114907) indicate that this gene has a log2 fold change of -1.215 and an adjusted p-value of 0.008903. Which disease is associated with this gene? | leukodystrophy, hypomyelinating, 14 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03706","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is involved in brain development. Experimental data from glioma stem cells (st... | |
medium_hidden_intermediate_03707 | A gene is downregulated by Cardiovirus A and enables DNA-binding transcription factor activity. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of approximately -1.333 and an adjusted p-value of 0.01434. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03707","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Cardiovirus A and enables DNA-binding transcription factor activity. Experimental data for this g... | |
medium_hidden_intermediate_03710 | Zika virus downregulates a gene that participates in Class A/1 (Rhodopsin-like receptors). In a study of glioma stem cells (GSE114907), one such gene exhibits a log2 fold change of -2.578 and an adjusted p-value of 0.01212. Which protein is encoded by this gene? | Neuropeptide Y receptor type 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03710","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in Class A/1 (Rhodopsin-like receptors). In a study of glioma stem cells (... | |
medium_hidden_intermediate_03711 | Pegivirus C is reported to downregulate a specific gene, the product of which interacts with PDPK1. In a study of peripheral blood mononuclear cells (GSE131504), this gene exhibited a log2 fold change of -1.545 and an adjusted p-value of 0.002355. What protein is encoded by this gene? | Golgi apparatus protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03711","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, the product of which interacts with PDPK1. In a study of peripheral... | |
medium_hidden_intermediate_03712 | In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and associated with metastatic melanoma. This specific gene exhibits a log2 fold change of approximately -1.196 and an adjusted p-value of 0.01537. Which protein is encoded by this gene? | Spermidine synthase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03712","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and asso... | |
medium_hidden_intermediate_03714 | Zika virus downregulates a gene that subsequently interacts with RABGEF1. In a study of glioma stem cells (GSE114907), this intermediate gene exhibited a log2 fold change of approximately -1.86 and an adjusted p-value of 0.0038. Which protein is encoded by this gene? | Ras-related protein Rab-21 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03714","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that subsequently interacts with RABGEF1. In a study of glioma stem cells (GSE114907), this ... | |
medium_hidden_intermediate_03716 | Two genes are upregulated by Human immunodeficiency virus 1 and participate in the RHO GTPase cycle. One of these genes exhibits a log2 fold change of 1.836 and an adjusted p-value of 0.03314 in a specific study. Which molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03716","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and participate in the RHO GTPase cycle. One of these genes exhi... | |
medium_hidden_intermediate_03717 | Two genes are upregulated by Enterovirus A and associated with glioma. One of these genes shows a log2 fold change of approximately 1.445 and an adjusted p-value of 0.00188 in rhabdomyosarcoma cells. Which disease is linked to this specific gene via a biomarker relationship? | secondary neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03717","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Enterovirus A and associated with glioma. One of these genes shows a log2 fold change of approx... | |
medium_hidden_intermediate_03718 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of specific genes that participate in GPCR downstream signalling. One such gene exhibits a log2 fold change of approximately -1.999 and an adjusted p-value of 0.02887. What molecular function is enabled by ... | hormone activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03718","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of specifi... | |
medium_hidden_intermediate_03719 | Zika virus upregulates a gene that is involved in the 2-oxoglutarate metabolic process. Transcriptomic data for this gene reports a log2 fold change of 1.021 and an adjusted p-value of 0.0169. Which protein is encoded by this gene? | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03719","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that is involved in the 2-oxoglutarate metabolic process. Transcriptomic data for this gene re... | |
medium_hidden_intermediate_03720 | Pegivirus C is reported to downregulate a gene that subsequently binds to TAF9. In a study of peripheral blood mononuclear cells (GSE131504), one such intermediate gene exhibits a log2 fold change of approximately -1.307 and an adjusted p-value of 0.001092. Which protein is encoded by this specific intermediate gene? | Transcription initiation factor TFIID subunit 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03720","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that subsequently binds to TAF9. In a study of peripheral blood mononuclear c... | |
medium_hidden_intermediate_03722 | Human betaherpesvirus 5 is linked to diabetic kidney disease via an intermediate gene that it upregulates, which is in turn associated with the disease. One such intermediate gene was reported in a study (GSE120891) involving retinal pigment epithelium cells, showing a log2 fold change of 5.865 and an adjusted p-value ... | C-X-C motif chemokine 11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03722","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is linked to diabetic kidney disease via an intermediate gene that it upregulates, which is in turn ... | |
medium_hidden_intermediate_03725 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Post-translational protein phosphorylation. One of these genes was reported in a study (GSE164073) on sclera cells with a log2 fold change of 1.141 and an adjusted p-value of 0.03166. Which gene is this, and what prote... | FAM20C | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03725","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Post-translational pro... | |
medium_hidden_intermediate_03726 | Two genes are upregulated by Measles morbillivirus and both enable dipeptide transmembrane transporter activity. One of these genes shows a log2 fold change of approximately 2.69 and an adjusted p-value of approximately 0.043 in pleural mesothelioma cells. Which disease is associated with this specific gene? | prostate cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03726","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Measles morbillivirus and both enable dipeptide transmembrane transporter activity. One of thes... | |
medium_hidden_intermediate_03727 | Rhinovirus A downregulates multiple genes that subsequently interact with PRKN. One such gene exhibits a log2 fold change of -1.297 and an adjusted p-value of 6.74e-05 in cytotoxic T-lymphocytes. Which cell type is this gene enriched in? | classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03727","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A downregulates multiple genes that subsequently interact with PRKN. One such gene exhibits a log2 fold change of... | |
medium_hidden_intermediate_03728 | Two genes are structurally linked to Pegivirus C via a 'downregulates' relationship and to guanyl-nucleotide exchange factor activity via an 'enables' relationship. One of these genes was reported in study GSE131504 (peripheral blood mononuclear cells) with a log2 fold change of approximately -1.26 and an adjusted p-va... | lupus vulgaris | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03728","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Pegivirus C via a 'downregulates' relationship and to guanyl-nucleotide exchange factor... | |
medium_hidden_intermediate_03730 | Zika virus downregulates a specific gene, which is located on a chromosome. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -2.154 and an adjusted p-value of 0.00642. Which gene interacts with this downregulated gene? | TRIM25 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03730","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which is located on a chromosome. In a study of glioma stem cells (GSE114907), thi... | |
medium_hidden_intermediate_03731 | In a study of Influenza A virus infection, a specific gene is downregulated by the virus and its product enables phospholipid binding. Experimental data for this gene reports a log2 fold change of -1.543 and an adjusted p-value of 0.02447. Which protein is encoded by this gene? | Gamma-aminobutyric acid receptor-associated protein-like 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03731","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is downregulated by the virus and its product enables phospholipi... | |
medium_hidden_intermediate_03734 | In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated and participates in tRNA processing. This gene exhibits a log2 fold change of approximately 1.87 and an adjusted p-value of approximately 1.14e-10. Which biological process is this gene involved in? | tRNA export from nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03734","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated and participates in... | |
medium_hidden_intermediate_03735 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to reactive arthritis via an association relationship. One of these genes was reported in a study (GSE157852) involving choroid plexus epithelium cells, showing a log2 fold change of 3.053 and an adjusted ... | Ras-specific guanine nucleotide-releasing factor 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03735","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to reacti... | |
medium_hidden_intermediate_03736 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in the M Phase. Evidence for this gene reports a log2 fold change of -1.094 and an adjusted p-value of 0.001746. Which gene does this entity bind to? | PTTG1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03736","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in the M Phase. Evidence for th... | |
medium_hidden_intermediate_03737 | Human polyomavirus 1 upregulates a gene that is involved in the cellular response to insulin-like growth factor stimulus. Evidence for this specific gene reports a log2 fold change of 2.268 and an adjusted p-value of 5.246e-06. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03737","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human polyomavirus 1 upregulates a gene that is involved in the cellular response to insulin-like growth factor stimulus. Ev... | |
medium_hidden_intermediate_03738 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Glucose metabolism. Experimental data for this gene reports a log2 fold change of 2.131 and an adjusted p-value of 0.04057. Which disease is associated with this gene through genomic alterations? | malaria | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03738","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Glucose metabolism. Exper... | |
medium_hidden_intermediate_03739 | Pegivirus C downregulates a specific gene that participates in Signaling by GPCR. Transcriptomic data from peripheral blood mononuclear cells (study GSE131504) indicates this gene has a log2 fold change of -1.475 and an adjusted p-value of 0.0004092. Which biological process is this gene involved in? | Rho protein signal transduction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03739","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a specific gene that participates in Signaling by GPCR. Transcriptomic data from peripheral blood ... | |
medium_hidden_intermediate_03741 | In a study of bronchial epithelial cells, a gene is identified as being downregulated by Severe acute respiratory syndrome-related coronavirus and interacting with CDK11A. This specific gene exhibits a log2 fold change of -1.681 and an adjusted p-value of 0.03189. Which protein is encoded by this gene? | Cyclin-L1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03741","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of bronchial epithelial cells, a gene is identified as being downregulated by Severe acute respiratory syndrome-r... | |
medium_hidden_intermediate_03742 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Ub-specific processing proteases. Evidence for this gene in a cardiomyocyte cell line (study GSE151879) reports a log2 fold change of 1.224 and an adjusted p-value of 0.01889. Which disease is connected to this gene throu... | ankylosing spondylitis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03742","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Ub-specific processing pr... | |
medium_hidden_intermediate_03743 | Human alphaherpesvirus 1 is associated with the downregulation of a gene that serves as a biomarker for breast carcinoma. In a study of monocytic leukemia cell lines (GSE114966), one such gene exhibited a log2 fold change of -1.071 and an adjusted p-value of 0.009454. Which protein is encoded by this gene? | Claudin-4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03743","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 is associated with the downregulation of a gene that serves as a biomarker for breast carcinoma. In... | |
medium_hidden_intermediate_03744 | Zika virus downregulates a gene that is involved in the regulation of exocytosis. In a study of glioma stem cells (GSE114907), one such gene showed a log2 fold change of -1.781 and an adjusted p-value of 0.02123. Which protein is encoded by this gene? | Syntaxin-binding protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03744","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the regulation of exocytosis. In a study of glioma stem cells (GSE114907... | |
medium_hidden_intermediate_03745 | In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress. Evidence for this specific gene reports a log2 fold change of approximately 1.23 and an... | Selenoprotein K | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03745","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus upregulates a gen... | |
medium_hidden_intermediate_03746 | Zika virus downregulates a specific gene, which in turn interacts with HSPA8. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -2.31 and an adjusted p-value of approximately 0.0041. Which gene does this entity bind to? | SMC4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03746","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with HSPA8. Experimental data for this gene in glioma stem... | |
medium_hidden_intermediate_03750 | Hepacivirus C is reported to downregulate a gene that is located in the cytoplasmic vesicle. Experimental data for one such gene indicates a log2 fold change of -1.455 and an adjusted p-value of 0.01256. Which disease is associated with this gene as a biomarker? | acute pancreatitis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03750","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that is located in the cytoplasmic vesicle. Experimental data for one such ... | |
medium_hidden_intermediate_03751 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a specific gene that participates in the regulation of Rab trafficking. This gene exhibited a log2 fold change of approximately 3.16 and an adjusted p-value of 9.68e-08. Which protein is encoded by this gene? | Vacuolar fusion protein MON1 homolog A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03751","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a specific gene tha... | |
medium_hidden_intermediate_03752 | A gene is downregulated by Primate bocaparvovirus 1 and enriched in Naive CD4+ T cells. Evidence for this gene reports a log2 fold change of -1.448 and an adjusted p-value of 0.008572. Which cellular component is this gene located in? | cytosol | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03752","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and enriched in Naive CD4+ T cells. Evidence for this gene reports a log... | |
medium_hidden_intermediate_03753 | Two distinct drugs are known to interact with both Sevelamer and Siponimod. One of these drugs is associated with clinical evidence showing that a single dose of Sevelamer significantly reduces the mean AUC of its active metabolite (MPA) by 25% (P<0.05) and the C(max) by 30%. Which disease is the drug exhibiting this s... | autoimmune hepatitis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03753","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct drugs are known to interact with both Sevelamer and Siponimod. One of these drugs is associated with clinical e... |
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