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medium_hidden_intermediate_03755 | In the context of Human immunodeficiency virus 1 infection, a specific gene is upregulated and subsequently linked to malignant colon neoplasm via genomic alterations. Experimental data from study GSE108897 in macrophages indicates that this gene exhibits a log2 fold change of approximately 4.20 and an adjusted p-value... | Dual specificity protein phosphatase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03755","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In the context of Human immunodeficiency virus 1 infection, a specific gene is upregulated and subsequently linked to malign... | |
medium_hidden_intermediate_03756 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the negative regulation of gene expression. Experimental data for this gene reports a log2 fold change of 1.712 and an adjusted p-value of 0.007671. Which cellular component is this gene located in? | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03756","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the negative regulation of... | |
medium_hidden_intermediate_03757 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Evidence for one such gene reports a log2 fold change of 1.724 and an adjusted p-value of 0.01445. Which protein is encoded by that gene? | F-box only protein 36 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03757","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the SCF-dependent proteasomal u... | |
medium_hidden_intermediate_03758 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of specific genes located in the cytosol. One such gene exhibits a log2 fold change of 5.189 and an adjusted p-value of 0.03433. Which biological process is this specific gene involved in? | signal transduction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03758","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of specific genes locate... | |
medium_hidden_intermediate_03759 | In a study of non-small cell lung adenocarcinoma, Influenza A virus infection was found to downregulate a specific gene that participates in vesicle-mediated transport. This gene exhibited a log2 fold change of -1.162 and an adjusted p-value of 4.858e-05. What molecular function is enabled by this gene? | hemoglobin binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03759","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma, Influenza A virus infection was found to downregulate a specific gene that... | |
medium_hidden_intermediate_03761 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in lipid metabolic process. Evidence for this gene reports a log2 fold change of 2.750 and an adjusted p-value of 0.02689. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03761","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in lipid metabolic process. E... | |
medium_hidden_intermediate_03762 | In a study of glioma stem cells (GSE114907), Zika virus downregulates a gene that participates in the Hedgehog 'off' state. One such gene exhibits a log2 fold change of -1.744 and an adjusted p-value of 0.01506. Which protein is encoded by this specific gene? | Centriole and centriolar satellite protein OFD1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03762","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), Zika virus downregulates a gene that participates in the Hedgehog 'off' state. ... | |
medium_hidden_intermediate_03764 | CFL1 interacts with a specific protein that enables protein binding. Evidence indicates this protein interacts with cofilin, dynein light chain 2A, alpha-adducin, ubiquitin activating enzyme E1, phosphoglycerate kinase 1, and platelet-activating factor acetylhydrolase alpha1-subunit. Which disease is associated with th... | gastric carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03764","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"CFL1 interacts with a specific protein that enables protein binding. Evidence indicates this protein interacts with cofilin,... | |
medium_hidden_intermediate_03766 | Human immunodeficiency virus 1 downregulates a gene that is enriched in Mucosa-associated invariant T (MAIT) cells. Evidence for this gene in macrophages reports a log2 fold change of -1.268 and an adjusted p-value of 0.002276. Which protein is encoded by this gene? | Copine-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03766","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is enriched in Mucosa-associated invariant T (MAIT) cells. Evidence... | |
medium_hidden_intermediate_03767 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to upregulate a specific gene that participates in collagen formation. This gene exhibited a log2 fold change of 2.529 and an adjusted p-value of 0.005768. Which protein is encoded by this gene? | Collagen alpha-1(XXII) chain | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03767","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_03768 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and its product is located in the Golgi membrane. Evidence for this gene reports a log2 fold change of -1.768 and an adjusted p-value of 0.03471. Which protein is encoded by this gene? | Bombesin receptor-activated protein C6orf89 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03768","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and its prod... | |
medium_hidden_intermediate_03769 | A gene is downregulated by Zika virus and serves as a biomarker for schizophrenia. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -2.371 and an adjusted p-value of 0.004346. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03769","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Zika virus and serves as a biomarker for schizophrenia. Experimental data for this gene in glioma... | |
medium_hidden_intermediate_03770 | In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and interacts with CCNF. This specific gene exhibits a log2 fold change of -1.262 and an adjusted p-value of 0.003326. Which protein is encoded by this gene? | Hsp70-binding protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03770","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and inte... | |
medium_hidden_intermediate_03771 | Two genes are structurally linked to Pegivirus C via a 'downregulates' relationship and to 'positive regulation of protein ubiquitination' via an 'involved in' relationship. One of these genes has a reported log2 fold change of -1.383 and an adjusted p-value of 0.01216 in peripheral blood mononuclear cells. Which cell ... | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03771","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Pegivirus C via a 'downregulates' relationship and to 'positive regulation of protein u... | |
medium_hidden_intermediate_03772 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with TRAF2. One such gene exhibits a log2 fold change of approximately 1.445 and an adjusted p-value of 0.002043 in lung cells. Which protein is encoded by this gene? | N-lysine methyltransferase SMYD2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03772","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with TRAF2. One such gene exhibits a... | |
medium_hidden_intermediate_03773 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate certain genes that participate in developmental biology. One such gene exhibited a log2 fold change of approximately 3.89 and an adjusted p-value of approximately 0.036. Which protein is encoded by this specific gene? | Semaphorin-6A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03773","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate certain genes that partici... | |
medium_hidden_intermediate_03774 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that is located in the endosome. One such gene exhibits a log2 fold change of approximately 4.67 and an adjusted p-value of 0.0024. Which protein is encoded by this specific gene? | B2 bradykinin receptor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03774","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that is located in the endosome. On... | |
medium_hidden_intermediate_03775 | Zika virus downregulates a gene that participates in cellular responses to stimuli. Evidence for this gene reports a log2 fold change of -1.864 and an adjusted p-value of 0.01206. Which cell type is this gene enriched in? | mucosal-associated invariant T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03775","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in cellular responses to stimuli. Evidence for this gene reports a log2 fo... | |
medium_hidden_intermediate_03776 | In a study of lung cells (GSE148697), a gene upregulated by Severe acute respiratory syndrome-related coronavirus and involved in the process 'RAB GEFs exchange GTP for GDP on RABs' showed a log2 fold change of 1.035 and an adjusted p-value of 0.0001099. Which disease is associated with this gene through genomic altera... | obesity disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03776","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells (GSE148697), a gene upregulated by Severe acute respiratory syndrome-related coronavirus and involv... | |
medium_hidden_intermediate_03778 | Hepacivirus C upregulates a gene that is involved in the cellular response to dopamine. Evidence for one such gene reports a log2 fold change of 2.506 and an adjusted p-value of 0.0004453. Which protein is encoded by that gene? | Sulfotransferase 1A3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03778","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in the cellular response to dopamine. Evidence for one such gene reports a... | |
medium_hidden_intermediate_03779 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in the metabolism of steroids. One of these genes exhibits a log2 fold change of approximately -1.81 and an adjusted p-value of 0.005151 in lung tissue. Which protein interacts with this specific gene product? | TRAF2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03779","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in the metabolism of st... | |
medium_hidden_intermediate_03780 | Zika virus downregulates a gene that interacts with PSMD6. In glioma stem cells, one such gene exhibits a log2 fold change of -2.075 and an adjusted p-value of 0.007052. Which protein is encoded by this gene? | Ubiquitin-like domain-containing CTD phosphatase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03780","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with PSMD6. In glioma stem cells, one such gene exhibits a log2 fold change o... | |
medium_hidden_intermediate_03782 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and both enable aminopeptidase activity. One of these genes was reported in a study of choroid plexus epithelium (GSE157852) with a log2 fold change of approximately 1.35 and an adjusted p-value of approximately 3.2e-05. Which biological... | peptide metabolic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03782","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and both enable aminopeptidase activity. ... | |
medium_hidden_intermediate_03784 | Human immunodeficiency virus 1 downregulates a gene that is located in the nucleolus. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of -1.208 and an adjusted p-value of 0.0174. Which protein is encoded by this gene? | U3 small nucleolar ribonucleoprotein protein IMP4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03784","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is located in the nucleolus. In a study of macrophages (GSE108897),... | |
medium_hidden_intermediate_03785 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and to zinc:proton antiporter activity via an 'enables' relationship. One of these genes is associated with experimental data showing a log2 fold change of approximately 2.05 and an adjusted p-va... | Zinc transporter 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03785","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship... | |
medium_hidden_intermediate_03786 | A gene is upregulated by Human gammaherpesvirus 8 and associated with carcinoma. Experimental data for this gene reports a log2 fold change of 1.183 and an adjusted p-value of 0.02962. Which protein is encoded by this gene? | Cytochrome P450 2J2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03786","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human gammaherpesvirus 8 and associated with carcinoma. Experimental data for this gene reports a l... | |
medium_hidden_intermediate_03790 | Pegivirus C downregulates a specific gene, which in turn participates in protein localization. Transcriptomic data from peripheral blood mononuclear cells (study GSE131504) indicates that this gene has a log2 fold change of approximately -1.14 and an adjusted p-value of 0.0014. Which protein does this gene interact wit... | TRAF2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03790","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a specific gene, which in turn participates in protein localization. Transcriptomic data from peri... | |
medium_hidden_intermediate_03791 | Two genes are downregulated by Pegivirus C and participate in aerobic respiration and respiratory electron transport. One of these genes exhibits a log2 fold change of approximately -1.445 and an adjusted p-value of 0.01045 in peripheral blood mononuclear cells (study GSE131504). Which disease is associated with this s... | intervertebral disk degenerative disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03791","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and participate in aerobic respiration and respiratory electron transport. One of... | |
medium_hidden_intermediate_03792 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to 'positive regulation of gene expression' via an 'involved in' relationship. One of these genes is associated with experimental data showing a log2 fold change of -1.327 and an adjusted p-... | PPP1R9B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03792","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_03793 | Enterovirus A upregulates a gene that is involved in endoplasmic reticulum tubular network organization. In a study of rhabdomyosarcoma cells (GSE103308), one such gene exhibited a log2 fold change of 6.981 and an adjusted p-value of 0.001955. Which protein is encoded by this specific gene? | Receptor expression-enhancing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03793","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A upregulates a gene that is involved in endoplasmic reticulum tubular network organization. In a study of rhabd... | |
medium_hidden_intermediate_03795 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is downregulated by Vaccinia virus and binds to RPS27A. This specific gene exhibits a log2 fold change of approximately -1.07 and an adjusted p-value of 0.0066. Which protein is encoded by this gene? | E3 ubiquitin-protein ligase RLIM | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03795","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is downregulated by Vaccinia virus and binds to RPS27A. ... | |
medium_hidden_intermediate_03796 | In a study of monocytic leukemia cell lines (GSE114966), Human alphaherpesvirus 1 infection leads to the upregulation of a specific gene, which in turn interacts with STK4. This gene exhibits a log2 fold change of 3.449 and an adjusted p-value of 0.02089. Which protein is encoded by this upregulated gene? | Histone H3.2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03796","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of monocytic leukemia cell lines (GSE114966), Human alphaherpesvirus 1 infection leads to the upregulation of a s... | |
medium_hidden_intermediate_03797 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the positive regulation of gene expression. Evidence for one such gene reports a log2 fold change of 1.119 and an adjusted p-value of 0.0004612. Which protein is encoded by that gene? | Band 4.1-like protein 4B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03797","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the positive regulation of gene... | |
medium_hidden_intermediate_03798 | Phenytoin and Sertraline are both known to interact with a specific intermediate drug. Clinical evidence indicates that the enzyme CYP2C19 is responsible for metabolizing this intermediate drug, as well as proton pump inhibitors (PPIs) and some antidepressants. Which disease is this intermediate drug indicated for? | peripheral arterial disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03798","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Phenytoin and Sertraline are both known to interact with a specific intermediate drug. Clinical evidence indicates that the ... | |
medium_hidden_intermediate_03799 | Hepacivirus C is reported to upregulate a gene that enables sequence-specific double-stranded DNA binding. In a specific study, this gene exhibited a log2 fold change of 1.674 and an adjusted p-value of 0.008793. Which protein is encoded by this gene? | Forkhead box protein Q1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03799","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to upregulate a gene that enables sequence-specific double-stranded DNA binding. In a specific stu... | |
medium_hidden_intermediate_03801 | Measles morbillivirus upregulates a gene that is involved in the negative regulation of transcription by RNA polymerase II. Evidence for this specific gene reports a log2 fold change of 1.334 and an adjusted p-value of 0.02884. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03801","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is involved in the negative regulation of transcription by RNA polymerase II. ... | |
medium_hidden_intermediate_03802 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the CHD3, CHD4, CHD5 subfamily. Experimental data for this gene in a colonic adenocarcinoma cell line (study GSE148729) reports a log2 fold change of approximately 2.02 and an adjusted p-value of approximately 0.036. Whic... | H3-4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03802","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the CHD3, CHD4, CHD5 subf... | |
medium_hidden_intermediate_03804 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the mitochondrial intermembrane space. Evidence for one such gene reports a log2 fold change of approximately 1.11 and an adjusted p-value of approximately 0.007. Which protein does this specific gene product bind to? | YME1L1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03804","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the mitochondrial intermembrane ... | |
medium_hidden_intermediate_03805 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with CEP63. One such gene exhibits a log2 fold change of 1.806 and an adjusted p-value of 0.01008. Which protein is encoded by this gene? | Coiled-coil domain-containing protein 138 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03805","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with CEP63. One such gene exhibits a... | |
medium_hidden_intermediate_03806 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and subsequently linked to 'transcription cis-regulatory region binding' via an 'enables' relationship. One of these genes is associated with experimental evidence showing a log2 fold change of ... | ATRIP | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03806","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_03807 | Human alphaherpesvirus 1 upregulates a gene that participates in the metabolism of lipids. In a study of monocytic leukemia cell lines (GSE114966), one such gene was found to have a log2 fold change of approximately 1.166 and an adjusted p-value of 0.03667. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03807","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that participates in the metabolism of lipids. In a study of monocytic leukemia ... | |
medium_hidden_intermediate_03809 | Pegivirus C downregulates a gene that is located in the centrosome. Evidence for one such gene reports a log2 fold change of -2.166 and an adjusted p-value of 0.04666. Which molecular function is enabled by that gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03809","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that is located in the centrosome. Evidence for one such gene reports a log2 fold change of... | |
medium_hidden_intermediate_03813 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in mitochondrial calcium ion transport. Evidence for one such gene reports a log2 fold change of 1.258 and an adjusted p-value of 0.04965. Which protein is encoded by that gene? | Essential MCU regulator, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03813","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in mitochondrial calcium ion tran... | |
medium_hidden_intermediate_03814 | Zika virus downregulates a specific gene, which in turn interacts with CDYL. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.79 and an adjusted p-value of approximately 0.0029. Which disease is associated with this gene as a biomarker? | prostate cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03814","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with CDYL. Experimental data for this gene in glioma stem ... | |
medium_hidden_intermediate_03815 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to Gamma delta (γδ) T cells via an 'enriched in' relationship. One of these genes has been reported in a study (GSE147507) with a log2 fold change of -1.022 and an adjusted p-value of 0.0003... | CD160 antigen | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03815","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_03816 | Severe acute respiratory syndrome-related coronavirus upregulates multiple genes that are located in the early endosome membrane. One such gene exhibits a log2 fold change of 1.483 and an adjusted p-value of 4.417e-08. Which protein is encoded by this specific gene? | 5'-3' exonuclease PLD3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03816","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates multiple genes that are located in the early endosome memb... | |
medium_hidden_intermediate_03817 | Measles morbillivirus downregulates a gene that enables RNA binding. Experimental data for this gene shows a log2 fold change of approximately -1.06 and an adjusted p-value of approximately 0.004. Which cellular component is this gene located in? | mitochondrion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03817","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus downregulates a gene that enables RNA binding. Experimental data for this gene shows a log2 fold chang... | |
medium_hidden_intermediate_03818 | Human alphaherpesvirus 3 is reported to downregulate a gene that is enriched in intermediate monocytes. Evidence for one such gene indicates a log2 fold change of -1.169 and an adjusted p-value of 6.646e-05. Which protein is encoded by this gene? | Protein phosphatase 1L | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03818","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 is reported to downregulate a gene that is enriched in intermediate monocytes. Evidence for one suc... | |
medium_hidden_intermediate_03820 | Cardiovirus A downregulates a gene that enables protein serine/threonine kinase activity. In a study of cervical adenocarcinoma cell lines (GSE122967), one such gene exhibits a log2 fold change of approximately -2.47 and an adjusted p-value of approximately 0.021. Which biological process is this specific gene involved... | mitotic cell cycle | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03820","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A downregulates a gene that enables protein serine/threonine kinase activity. In a study of cervical adenocarcin... | |
medium_hidden_intermediate_03821 | A gene is downregulated by Enterovirus A and participates in Neutrophil degranulation. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) reports a log2 fold change of -2.044 and an adjusted p-value of 0.04077. Which disease is associated with this gene as a biomarker? | prostate carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03821","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Enterovirus A and participates in Neutrophil degranulation. Experimental data for this gene in rh... | |
medium_hidden_intermediate_03823 | Human betaherpesvirus 5 upregulates a gene that participates in the metabolism of lipids. Evidence for one such gene reports a log2 fold change of approximately 1.025 and an adjusted p-value of 0.02746. Which molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03823","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that participates in the metabolism of lipids. Evidence for one such gene reports... | |
medium_hidden_intermediate_03825 | Zika virus downregulates a gene that is located in the endosome. In a study of glioma stem cells (GSE114907), one such gene exhibits a log2 fold change of -1.556 and an adjusted p-value of 0.01773. Which protein is encoded by this specific gene? | Arrestin domain-containing protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03825","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in the endosome. In a study of glioma stem cells (GSE114907), one such gene ... | |
medium_hidden_intermediate_03826 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that interacts with CANX. One such gene exhibits a log2 fold change of 3.886 and an adjusted p-value of 0.01063. Which protein is encoded by this specific gene? | Thiol S-methyltransferase TMT1A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03826","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that interacts with CANX. One such ... | |
medium_hidden_intermediate_03827 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes involved in the metabolism of water-soluble vitamins and cofactors. One such gene exhibited a log2 fold change of approximately 1.183 and an adjusted p-value of 0.0001551. Which protein is encoded... | NAD kinase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03827","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes ... | |
medium_hidden_intermediate_03828 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with colon carcinoma. One of these genes exhibits a log2 fold change of approximately 2.85 and an adjusted p-value of 0.0169 in a specific study. Which cell type is enriched for this specific gene? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03828","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with colon carcinoma. ... | |
medium_hidden_intermediate_03829 | In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and interacts with KRAS. This gene exhibits a log2 fold change of approximately 1.209 and an adjusted p-value of 0.00804. Which disease is associated with this gene? | carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03829","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and interacts with KRAS. This... | |
medium_hidden_intermediate_03830 | In a study of Measles morbillivirus infection, two genes are known to be upregulated by the virus and are involved in the positive regulation of interferon-beta production. One of these genes exhibits a log2 fold change of 1.097 and an adjusted p-value of 0.001947. Which protein is encoded by this specific gene? | Serine/threonine-protein kinase RIO3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03830","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, two genes are known to be upregulated by the virus and are involved in the po... | |
medium_hidden_intermediate_03832 | In a study of foreskin fibroblast cell lines (GSE132081), Human betaherpesvirus 5 was found to upregulate a specific gene, which in turn enables protein homodimerization activity. This gene exhibited a log2 fold change of approximately 5.37 and an adjusted p-value of 0.0236. Which protein is encoded by this gene? | Histatin-3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03832","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of foreskin fibroblast cell lines (GSE132081), Human betaherpesvirus 5 was found to upregulate a specific gene, w... | |
medium_hidden_intermediate_03833 | Human alphaherpesvirus 3 upregulates a gene that is involved in signal transduction. Evidence for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of approximately 1.15 and an adjusted p-value of 4.4e-09. Which disease is associated with genomic alterations in this specific gene? | breast cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03833","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 upregulates a gene that is involved in signal transduction. Evidence for this gene in a melanoma ce... | |
medium_hidden_intermediate_03834 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in glutathione conjugation. Evidence for one such gene reports a log2 fold change of approximately 1.004 and an adjusted p-value of 0.009185. Which protein is encoded by that gene? | Glutathione-specific gamma-glutamylcyclotransferase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03834","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in glutathione conjugation. Evide... | |
medium_hidden_intermediate_03836 | Human betaherpesvirus 5 upregulates a gene that participates in post-translational protein modification. Evidence for this gene in foreskin fibroblast cell lines reports a log2 fold change of approximately 3.56 and an adjusted p-value of approximately 0.0306. Which cellular component is this gene located in? | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03836","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that participates in post-translational protein modification. Evidence for this g... | |
medium_hidden_intermediate_03837 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that subsequently binds to GNAI2. One such gene exhibits a log2 fold change of 1.472 and an adjusted p-value of 4.889e-05. Which protein is encoded by this gene? | Cortistatin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03837","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that subsequently binds to GNAI2. One such gene exh... | |
medium_hidden_intermediate_03838 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with BRCA1. One of these genes shows a log2 fold change of 1.364 and an adjusted p-value of 1.855e-05 in a specific study. Which protein is encoded by this gene? | CB1 cannabinoid receptor-interacting protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03838","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with BRCA1. One of these gen... | |
medium_hidden_intermediate_03839 | In a study of Influenza A virus infection, a specific gene is downregulated by the virus and localized to the cytosol. Transcriptomic data for this gene shows a log2 fold change of -1.374 and an adjusted p-value of 8.072e-10. Which biological process is this gene involved in? | pore complex assembly | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03839","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is downregulated by the virus and localized to the cytosol. Trans... | |
medium_hidden_intermediate_03840 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 is reported to downregulate a gene that is involved in chemical synaptic transmission. One such gene exhibits a log2 fold change of -7.270 and an adjusted p-value of 0.01246. Which protein is encoded by this specific gene? | Neuronal pentraxin-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03840","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 is reported to downregulate a gene that is involved in... | |
medium_hidden_intermediate_03841 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables peptidase activity. Experimental evidence for this gene reports a log2 fold change of -3.583 and an adjusted p-value of 0.03917. Which disease is associated with this gene through genomic alterations? | hemophilia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03841","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables peptidase activity. Experimenta... | |
medium_hidden_intermediate_03843 | In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and is involved in protein phosphorylation. This gene exhibits a log2 fold change of approximately 3.45 and an adjusted p-value of approximately 0.0048. Which protein is encoded by this gene? | Inositol hexakisphosphate kinase 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03843","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and is involved in protein phosph... | |
medium_hidden_intermediate_03845 | A protein interacts with CUL3 and possesses protein binding activity. Experimental evidence using yeast two-hybrid analysis and co-immunoprecipitation demonstrates that all three RhoBTB proteins interact with Cul3. Which cellular component is associated with the specific RhoBTB protein identified in this evidence throu... | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03845","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A protein interacts with CUL3 and possesses protein binding activity. Experimental evidence using yeast two-hybrid analysis ... | |
medium_hidden_intermediate_03846 | A gene is downregulated by Primate bocaparvovirus 1 and is involved in the immune response. Experimental data for this gene shows a log2 fold change of -2.051 and an adjusted p-value of 0.03959. Which cellular component is this gene located in? | membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03846","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and is involved in the immune response. Experimental data for this gene ... | |
medium_hidden_intermediate_03847 | Two genes are structurally linked to Cardiovirus A via a 'downregulates' relationship and to 'negative regulation of transcription by RNA polymerase II' via an 'involved in' relationship. One of these genes has an associated experimental record showing a log2 fold change of -1.300 and an adjusted p-value of 0.03362. Wh... | purpura | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03847","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Cardiovirus A via a 'downregulates' relationship and to 'negative regulation of transcr... | |
medium_hidden_intermediate_03848 | Zika virus downregulates a specific gene that is involved in cell population proliferation. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -1.811 and an adjusted p-value of 0.02553. Which protein is encoded by this gene? | Integrator complex assembly factor BRAT1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03848","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is involved in cell population proliferation. In a study of glioma stem cells ... | |
medium_hidden_intermediate_03849 | DLG1 interacts with a specific protein that enables PDZ domain binding. Experimental evidence indicates that a complex containing SAP97, CASK, Veli, and Mint1 associates with Kir2 channels via their C-terminal PDZ-binding motif. Which protein, encoded by the gene connected to DLG1 in this context, is the subject of thi... | Inward rectifier potassium channel 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03849","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"DLG1 interacts with a specific protein that enables PDZ domain binding. Experimental evidence indicates that a complex conta... | |
medium_hidden_intermediate_03850 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and its product binds to SAP130. Experimental data for this gene reports a log2 fold change of 1.137 and an adjusted p-value of 0.03017. Which protein is encoded by this gene? | Bromodomain adjacent to zinc finger domain protein 2A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03850","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and its product binds to SAP130. Experimental... | |
medium_hidden_intermediate_03852 | Zaire ebolavirus infection leads to the upregulation of certain genes that participate in neutrophil degranulation. In a study of retinal pigment epithelium cells (GSE100839), one such gene exhibited a log2 fold change of approximately 1.88 and an adjusted p-value of 0.0005557. Which protein is encoded by this specific... | Tumor necrosis factor-inducible gene 6 protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03852","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus infection leads to the upregulation of certain genes that participate in neutrophil degranulation. In a stu... | |
medium_hidden_intermediate_03853 | Zaire ebolavirus downregulates a gene that participates in G alpha (s) signalling events. In a study of retinal pigment epithelium cells (GSE100839), one such gene showed a log2 fold change of -1.207 and an adjusted p-value of 0.007031. Which protein is encoded by this gene? | G protein-coupled receptor kinase 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03853","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus downregulates a gene that participates in G alpha (s) signalling events. In a study of retinal pigment epit... | |
medium_hidden_intermediate_03854 | Hepacivirus C upregulates a gene that participates in the Innate Immune System. Evidence for this gene reports a log2 fold change of 2.532 and an adjusted p-value of 8.387e-12. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03854","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in the Innate Immune System. Evidence for this gene reports a log2 fold c... | |
medium_hidden_intermediate_03855 | Pegivirus C is reported to downregulate a specific gene, which in turn interacts with BECN1. Experimental data for this intermediate gene in peripheral blood mononuclear cells (from study GSE131504) shows a log2 fold change of approximately -1.13 and an adjusted p-value of 0.001155. Which disease is associated with thi... | neurodevelopmental disorder with microcephaly, seizures, and brain atrophy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03855","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn interacts with BECN1. Experimental data for this inte... | |
medium_hidden_intermediate_03857 | Human immunodeficiency virus 1 downregulates a gene that is involved in natural killer cell mediated cytotoxicity. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of -3.625 and an adjusted p-value of 0.01223. Which protein is encoded by this gene? | UL16-binding protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03857","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is involved in natural killer cell mediated cytotoxicity. In a stud... | |
medium_hidden_intermediate_03858 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the MyD88 dependent cascade initiated on endosome. Evidence for one such gene reports a log2 fold change of 1.466 and an adjusted p-value of 6.958e-07. Which protein is encoded by that gene? | Dual specificity protein phosphatase 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03858","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the MyD88 dependent cascade in... | |
medium_hidden_intermediate_03859 | In a study of Influenza A virus infection, a specific gene is upregulated by the virus and is associated with hyperlipidemia. Evidence for this gene reports a log2 fold change of 1.137 and an adjusted p-value of 0.0001429. Which protein is encoded by this gene? | Chloride intracellular channel protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03859","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is upregulated by the virus and is associated with hyperlipidemia... | |
medium_hidden_intermediate_03860 | Human alphaherpesvirus 3 upregulates a gene that is involved in the antimicrobial humoral immune response mediated by antimicrobial peptide. Evidence for one such gene reports a log2 fold change of 1.028 and an adjusted p-value of 5.142e-08. Which disease is associated with this gene as a biomarker? | obesity disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03860","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 upregulates a gene that is involved in the antimicrobial humoral immune response mediated by antimi... | |
medium_hidden_intermediate_03864 | In a study of rhabdomyosarcoma cells (GSE103308), a gene is upregulated by Enterovirus A and associated with epilepsy. This specific gene exhibits a log2 fold change of 8.255 and an adjusted p-value of 0.00893. Which protein is encoded by this gene? | Glutaminase liver isoform, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03864","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), a gene is upregulated by Enterovirus A and associated with epilepsy. This ... | |
medium_hidden_intermediate_03865 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene that participates in the Toll Like Receptor 7/8 (TLR7/8) Cascade. This gene exhibited a log2 fold change of approximately 1.228 and an adjusted p-value of 1.231e-10. Which protein is encoded by ... | NF-kappa-B inhibitor-interacting Ras-like protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03865","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_03866 | A gene is upregulated by Hepacivirus C and enriched in Gamma delta (γδ) T cells. Evidence for this gene reports a log2 fold change of 2.594 and an adjusted p-value of 0.03827. Which molecular function is enabled by this gene? | protein-glucosylgalactosylhydroxylysine glucosidase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03866","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Hepacivirus C and enriched in Gamma delta (γδ) T cells. Evidence for this gene reports a log2 fold ... | |
medium_hidden_intermediate_03868 | GTF2F2 interacts with a specific protein, which in turn interacts with TBP. Evidence indicates that this intermediate protein forms a ternary complex with TBP and TAF13, and is described as a histone fold (HF) domain-containing TFIID subunit. Which protein is encoded by the gene corresponding to this intermediate entit... | Transcription initiation factor TFIID subunit 11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03868","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"GTF2F2 interacts with a specific protein, which in turn interacts with TBP. Evidence indicates that this intermediate protei... | |
medium_hidden_intermediate_03869 | Astrocytes express a specific protein marker that enables identical protein binding. Evidence indicates that this protein homodimerizes and can also heterodimerize with the related protein CASTOR2. Which cell type is enriched for this protein? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03869","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Astrocytes express a specific protein marker that enables identical protein binding. Evidence indicates that this protein ho... | |
medium_hidden_intermediate_03870 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the negative regulation of apoptotic process. Evidence for this gene reports a log2 fold change of 1.404 and an adjusted p-value of 0.008001. Which disease is associated with this gene? | renal cell carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03870","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the negative regulation of... | |
medium_hidden_intermediate_03873 | Zika virus downregulates a specific gene that participates in Signaling by Receptor Tyrosine Kinases. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -3.02 and an adjusted p-value of approximately 0.0039. Which disease is associated with this gene as a ... | carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03873","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in Signaling by Receptor Tyrosine Kinases. Experimental data for ... | |
medium_hidden_intermediate_03874 | Pegivirus C downregulates a gene that subsequently interacts with YWHAH. Evidence for one such gene reports a log2 fold change of -2.096 and an adjusted p-value of 0.02797. Which molecular function is enabled by that gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03874","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that subsequently interacts with YWHAH. Evidence for one such gene reports a log2 fold chan... | |
medium_hidden_intermediate_03875 | Enterovirus A is reported to upregulate a specific gene, which is subsequently found to be enriched in naive CD4+ T cells. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) indicates a log2 fold change of 1.815 and an adjusted p-value of 0.003093. Which protein interacts with this gene product... | PRKACA | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03875","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is reported to upregulate a specific gene, which is subsequently found to be enriched in naive CD4+ T cells. E... | |
medium_hidden_intermediate_03876 | Two genes are upregulated by Human alphaherpesvirus 1 and enriched in eosinophils. One of these genes has a reported log2 fold change of 1.234 and an adjusted p-value of 0.02889. Which molecular function is enabled by this specific gene? | potassium channel activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03876","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human alphaherpesvirus 1 and enriched in eosinophils. One of these genes has a reported log2 fo... | |
medium_hidden_intermediate_03877 | Rhinovirus A downregulates a specific gene that is involved in the defense response. Transcriptomic data for this gene in cytotoxic T-lymphocytes (study GSE106475) reports a log2 fold change of approximately -1.58 and an adjusted p-value of 0.0026. Which molecular function is enabled by this gene? | RNA nuclease activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03877","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A downregulates a specific gene that is involved in the defense response. Transcriptomic data for this gene in cy... | |
medium_hidden_intermediate_03878 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Nervous system development. Experimental data for this gene in choroid plexus epithelium shows a log2 fold change of 1.012 and an adjusted p-value of 0.0009571. Which protein is encoded by this gene? | Docking protein 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03878","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Nervous system developmen... | |
medium_hidden_intermediate_03880 | Human immunodeficiency virus 1 downregulates a gene that is associated with breast carcinoma through genomic alterations. Evidence for this gene in a specific study (GSE108897) reports a log2 fold change of approximately -1.51 and an adjusted p-value of 0.001489. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03880","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is associated with breast carcinoma through genomic alterations. Ev... | |
medium_hidden_intermediate_03881 | Human betaherpesvirus 5 is reported to downregulate multiple genes that are associated with prostate cancer. One such gene exhibits a log2 fold change of -1.191 and an adjusted p-value of 5.303e-07 in foreskin fibroblast cell lines (study GSE130665). Which protein is encoded by this specific gene? | Ketimine reductase mu-crystallin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03881","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate multiple genes that are associated with prostate cancer. One such gene e... | |
medium_hidden_intermediate_03883 | Zika virus downregulates a specific gene that is associated with carcinoma. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -1.308 and an adjusted p-value of 0.01698. Which protein is encoded by this gene? | E3 ubiquitin-protein ligase RNF139 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03883","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is associated with carcinoma. In a study of glioma stem cells (GSE114907), thi... | |
medium_hidden_intermediate_03886 | In a study of macrophages (GSE108897), a gene downregulated by Human immunodeficiency virus 1 and associated with disease showed a log2 fold change of -1.056 and an adjusted p-value of 0.02949. Which protein is encoded by this gene? | Neuronal pentraxin receptor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03886","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene downregulated by Human immunodeficiency virus 1 and associated with disease sh... | |
medium_hidden_intermediate_03889 | A gene is upregulated by Measles morbillivirus and associated with lung cancer through genomic alterations. Evidence for this gene reports a log2 fold change of approximately 1.097 and an adjusted p-value of 0.01715. Which cellular component is this gene located in? | extracellular matrix | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03889","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and associated with lung cancer through genomic alterations. Evidence for thi... | |
medium_hidden_intermediate_03890 | Hepacivirus C upregulates a gene that is involved in protein polyubiquitination. Experimental data for this gene in hepatocytes (study GSE132606) reports a log2 fold change of approximately 1.904 and an adjusted p-value of 0.003572. Which cellular component is this gene located in? | Cul4-RING E3 ubiquitin ligase complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03890","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in protein polyubiquitination. Experimental data for this gene in hepatocy... | |
medium_hidden_intermediate_03891 | Hepacivirus C is reported to upregulate a gene that subsequently binds to SRSF6. Experimental data for one such intermediate gene indicates a log2 fold change of approximately 1.224 and an adjusted p-value of 0.0004699. Which protein is encoded by this specific gene? | NTF2-related export protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03891","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to upregulate a gene that subsequently binds to SRSF6. Experimental data for one such intermediate... |
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