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medium_hidden_intermediate_03892 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Diseases of glycosylation. Evidence for this gene reports a log2 fold change of 1.889 and an adjusted p-value of 0.006198. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03892","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Diseases of glycosylation... | |
medium_hidden_intermediate_03893 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in a transcription repressor complex. Evidence for this specific gene reports a log2 fold change of 1.956 and an adjusted p-value of 0.01751. Which protein is encoded by this gene? | Coronin-2A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03893","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in a transcription repressor comple... | |
medium_hidden_intermediate_03894 | Pegivirus C is reported to downregulate a gene that is involved in signal transduction. Transcriptomic data from peripheral blood mononuclear cells (study GSE131504) indicates that this specific gene has a log2 fold change of approximately -1.35 and an adjusted p-value of approximately 0.021. Which protein interacts wi... | CYTH1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03894","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in signal transduction. Transcriptomic data from peripheral ... | |
medium_hidden_intermediate_03895 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Complex III assembly. Evidence for this gene reports a log2 fold change of 1.274 and an adjusted p-value of 0.03817. Which protein is encoded by this gene? | Ubiquinol-cytochrome c reductase complex assembly factor 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03895","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Complex III assembly. Evi... | |
medium_hidden_intermediate_03897 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the regulation of transcription by RNA polymerase II. Evidence for this specific gene reports a log2 fold change of 3.333 and an adjusted p-value of 0.03363. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03897","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the regulation of transcription... | |
medium_hidden_intermediate_03898 | A gene serves as a marker for B cells and is enriched in conventional dendritic cells. Expression data for this gene indicates a mean expression of 35.79 TPM, a z-score of 1.77, and a fold enrichment of 2.57. Which disease is associated with this gene as a biomarker? | cataract | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03898","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for B cells and is enriched in conventional dendritic cells. Expression data for this gene indicat... | |
medium_hidden_intermediate_03899 | Vaccinia virus downregulates a gene that participates in the Adaptive Immune System. In a study of cervical adenocarcinoma cell lines (GSE11238), one such gene exhibits a log2 fold change of -1.044 and an adjusted p-value of 0.02825. Which protein is encoded by this specific gene? | E3 ubiquitin-protein ligase RNF19B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03899","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus downregulates a gene that participates in the Adaptive Immune System. In a study of cervical adenocarcinoma c... | |
medium_hidden_intermediate_03901 | Human immunodeficiency virus 1 downregulates a gene that participates in COPII-mediated vesicle transport. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of -1.574 and an adjusted p-value of 0.003618. Which protein is encoded by this gene? | Guanine nucleotide-exchange factor SEC12 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03901","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in COPII-mediated vesicle transport. In a study of mac... | |
medium_hidden_intermediate_03903 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and involved in the negative regulation of protein phosphorylation. This gene exhibits a log2 fold change of 1.048 and an adjusted p-value of 2.791e-07. Which protein is encoded by this gene? | Protein phosphatase 1 regulatory subunit 15B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03903","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and i... | |
medium_hidden_intermediate_03904 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with SOCS6. Evidence for this gene reports a log2 fold change of 1.479 and an adjusted p-value of 0.04833. Which biological process is this gene involved in? | protein insertion into mitochondrial inner membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03904","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with SOCS6. Evidence for this g... | |
medium_hidden_intermediate_03905 | Pegivirus C is reported to downregulate a gene that is involved in Golgi organization. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -2.81 and an adjusted p-value of 0.0488. Which protein is encoded by this specific gene? | LysM and putative peptidoglycan-binding domain-containing protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03905","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in Golgi organization. In a study of peripheral blood mononu... | |
medium_hidden_intermediate_03907 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in the metabolism of vitamins and cofactors. Experimental data for this gene reports a log2 fold change of -1.451 and an adjusted p-value of 0.0002178. Which cellular component is this gene located in? | membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03907","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in the metabolism of vitam... | |
medium_hidden_intermediate_03910 | Two genes are upregulated by Human immunodeficiency virus 1 and participate in RAB geranylgeranylation. One of these genes exhibits a log2 fold change of 4.468 and an adjusted p-value of 0.02236 in a specific study. Which cell type is enriched for this specific gene? | conventional dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03910","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and participate in RAB geranylgeranylation. One of these genes e... | |
medium_hidden_intermediate_03912 | Zika virus downregulates a gene that is involved in the cellular response to calcium ion. Evidence for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -1.905 and an adjusted p-value of 0.0464. Which protein is encoded by this gene? | Inositol-trisphosphate 3-kinase C | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03912","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the cellular response to calcium ion. Evidence for this gene in glioma s... | |
medium_hidden_intermediate_03913 | Human betaherpesvirus 5 upregulates a gene that is involved in animal organ morphogenesis. Evidence for this gene reports a log2 fold change of 4.369 and an adjusted p-value of 0.0006947. Which disease is associated with this gene? | mammary neoplasms, animal | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03913","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that is involved in animal organ morphogenesis. Evidence for this gene reports a ... | |
medium_hidden_intermediate_03916 | Pegivirus C is reported to downregulate a gene that subsequently interacts with SF3B6. In a study of peripheral blood mononuclear cells (GSE131504), one such intermediate gene exhibits a log2 fold change of -1.989 and an adjusted p-value of 0.009058. Which protein is encoded by this specific gene? | Tetratricopeptide repeat protein 33 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03916","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that subsequently interacts with SF3B6. In a study of peripheral blood mononu... | |
medium_hidden_intermediate_03917 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene that participates in GPCR signaling. This gene exhibited a log2 fold change of approximately 2.75 and an adjusted p-value of approximately 2.8e-07. Which protein is encoded by this gene? | Rho guanine nucleotide exchange factor 39 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03917","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_03918 | In a study of glioma stem cells (GSE114907), a gene is identified as being downregulated by Zika virus and serving as a biomarker for telangiectasis. This specific gene exhibits a log2 fold change of approximately -1.20 and an adjusted p-value of 0.0085. Which protein is encoded by this gene? | Nibrin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03918","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), a gene is identified as being downregulated by Zika virus and serving as a biom... | |
medium_hidden_intermediate_03919 | Two genes are upregulated by Enterovirus A and are involved in the proteasome-mediated ubiquitin-dependent protein catabolic process. One of these genes exhibits a log2 fold change of approximately 1.007 and an adjusted p-value of 0.0084 in rhabdomyosarcoma cells. Which cell type is enriched for this specific gene? | mucosal-associated invariant T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03919","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Enterovirus A and are involved in the proteasome-mediated ubiquitin-dependent protein catabolic... | |
medium_hidden_intermediate_03920 | Pegivirus C is reported to downregulate a specific gene, which is subsequently involved in the positive regulation of transcription by RNA polymerase II. Experimental data from a study on peripheral blood mononuclear cells (GSE131504) indicates that this gene exhibits a log2 fold change of approximately -2.26 and an ad... | Aryl hydrocarbon receptor nuclear translocator | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03920","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which is subsequently involved in the positive regulation of transc... | |
medium_hidden_intermediate_03924 | Zika virus downregulates a specific gene that is enriched in Gamma delta (γδ) T cells. Evidence for this gene reports a log2 fold change of -1.218 and an adjusted p-value of 0.03675. Which biological process is this gene involved in? | negative regulation of T cell receptor signaling pathway | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03924","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is enriched in Gamma delta (γδ) T cells. Evidence for this gene reports a log2... | |
medium_hidden_intermediate_03925 | Hepacivirus C is reported to downregulate a gene that participates in the transport of small molecules. Evidence for one such gene shows a log2 fold change of -1.271 and an adjusted p-value of 0.03465. Which cell type is this gene enriched in? | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03925","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that participates in the transport of small molecules. Evidence for one suc... | |
medium_hidden_intermediate_03926 | Rhinovirus A infection leads to the upregulation of specific genes, some of which encode proteins that interact with HSPA8. In a study of cytotoxic T-lymphocytes (GSE106475), one such upregulated gene exhibited a log2 fold change of approximately 1.72 and an adjusted p-value of approximately 0.04. Which protein is enco... | DnaJ homolog subfamily B member 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03926","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection leads to the upregulation of specific genes, some of which encode proteins that interact with HSPA8. ... | |
medium_hidden_intermediate_03927 | Zika virus downregulates a gene that participates in N-glycan trimming in the ER and the Calnexin/Calreticulin cycle. In glioma stem cells, this gene exhibits a log2 fold change of approximately -1.97 and an adjusted p-value of 0.012. Which biological process is this gene involved in? | 'de novo' post-translational protein folding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03927","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in N-glycan trimming in the ER and the Calnexin/Calreticulin cycle. In gli... | |
medium_hidden_intermediate_03929 | Zika virus downregulates a specific gene, which in turn interacts with CANX. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -2.245 and an adjusted p-value of 0.005369. What molecular function is enabled by this gene? | Hsp70 protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03929","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with CANX. Experimental data for this gene in glioma stem ... | |
medium_hidden_intermediate_03930 | Zaire ebolavirus upregulates a gene that is associated with breast carcinoma. In a study of retinal pigment epithelium cells (GSE100839), one such gene exhibited a log2 fold change of approximately 6.58 and an adjusted p-value of 0.0022. Which protein is encoded by this specific gene? | Antiviral innate immune response effector IFIT1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03930","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus upregulates a gene that is associated with breast carcinoma. In a study of retinal pigment epithelium cells... | |
medium_hidden_intermediate_03932 | Severe acute respiratory syndrome-related coronavirus is reported to downregulate a gene that subsequently binds to PDGFRA. Experimental data for one such gene indicates a log2 fold change of approximately -1.75 and an adjusted p-value of 1.507e-14. Which protein is encoded by this specific gene? | Platelet-derived growth factor C | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03932","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus is reported to downregulate a gene that subsequently binds to PDGFRA. ... | |
medium_hidden_intermediate_03933 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene, which is also enriched in natural killer cells. This gene exhibited a log2 fold change of 2.401 and an adjusted p-value of 0.0003591. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03933","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene, which is ... | |
medium_hidden_intermediate_03934 | Pegivirus C is reported to downregulate a gene that participates in aerobic respiration and respiratory electron transport. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.196 and an adjusted p-value of 0.00147. Which protein is encoded by this specific gen... | Cytochrome b-c1 complex subunit 2, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03934","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that participates in aerobic respiration and respiratory electron transport. ... | |
medium_hidden_intermediate_03935 | Zaire ebolavirus infection leads to the upregulation of certain genes whose products are located in the cytoplasm. In a study of retinal pigment epithelium cells (GSE100839), one such gene exhibited a log2 fold change of 3.254 and an adjusted p-value of 0.0006371. Which protein is encoded by this specific gene? | XIAP-associated factor 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03935","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus infection leads to the upregulation of certain genes whose products are located in the cytoplasm. In a stud... | |
medium_hidden_intermediate_03936 | In a study of Measles morbillivirus infection, a specific gene is upregulated and participates in the biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and its transfer to a nascent protein. Evidence for this gene reports a log2 fold change of 1.314 and an adjusted p-value of 0.002031.... | Golgi membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03936","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is upregulated and participates in the biosynthesis of the N-... | |
medium_hidden_intermediate_03938 | Zika virus upregulates a specific gene that participates in the epigenetic regulation of gene expression. In a study (GSE129180) involving neural stem cells, this gene exhibited a log2 fold change of approximately 1.014 and an adjusted p-value of approximately 0.0433. Which cell type is this gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03938","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a specific gene that participates in the epigenetic regulation of gene expression. In a study (GSE129... | |
medium_hidden_intermediate_03940 | Two genes are downregulated by Zika virus and both bind to SNW1. One of these genes exhibits a log2 fold change of -3.431 and an adjusted p-value of 0.003916 in glioma stem cells. Which disease is associated with this specific gene? | achalasia-progeroid syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03940","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Zika virus and both bind to SNW1. One of these genes exhibits a log2 fold change of -3.431 an... | |
medium_hidden_intermediate_03941 | In a study of rhabdomyosarcoma cells, a gene is upregulated by Enterovirus A and interacts with BAG3. This specific gene exhibits a log2 fold change of 1.586 and an adjusted p-value of 0.004729. Which protein is encoded by this gene? | Protein N-lysine methyltransferase METTL21A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03941","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells, a gene is upregulated by Enterovirus A and interacts with BAG3. This specific gene exh... | |
medium_hidden_intermediate_03942 | GNG13 binds to an olfactory receptor that enables olfactory receptor activity. Evidence indicates that this specific receptor is expressed in various cell types and regulates physiological functions beyond olfaction, notably by stimulating keratinocyte proliferation in the skin. Which biological process is this recepto... | positive regulation of ERK1 and ERK2 cascade | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03942","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"GNG13 binds to an olfactory receptor that enables olfactory receptor activity. Evidence indicates that this specific recepto... | |
medium_hidden_intermediate_03943 | Hepacivirus C is reported to upregulate a gene that is involved in the positive regulation of canonical NF-kappaB signal transduction. Evidence for one such gene reports a log2 fold change of 1.494 and an adjusted p-value of 0.0001629. Which protein is encoded by that gene? | Innate immunity activator protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03943","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to upregulate a gene that is involved in the positive regulation of canonical NF-kappaB signal tra... | |
medium_hidden_intermediate_03946 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the downregulation of a specific gene, which in turn interacts with HIST3H3. This gene exhibits a log2 fold change of -3.913 and an adjusted p-value of 0.03017. Which protein is encoded by this downregulated gene? | PHD finger protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03946","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_03948 | Human betaherpesvirus 5 upregulates a gene that enables chromatin binding. In a study of foreskin fibroblast cell lines (GSE111036), one such gene showed a log2 fold change of 1.833 and an adjusted p-value of 0.04101. Which protein is encoded by this gene? | Neurotrophin receptor-interacting factor homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03948","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that enables chromatin binding. In a study of foreskin fibroblast cell lines (GSE... | |
medium_hidden_intermediate_03950 | Human immunodeficiency virus 1 upregulates a gene that is associated with disease. Evidence for this gene reports a log2 fold change of 1.663 and an adjusted p-value of 0.03089. Which protein is encoded by this gene? | Linker for activation of T-cells family member 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03950","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is associated with disease. Evidence for this gene reports a log2 fol... | |
medium_hidden_intermediate_03951 | Cardiovirus A upregulates a gene that is located in the extracellular space. In a study of cervical adenocarcinoma cell lines (GSE122967), one such gene showed a log2 fold change of 1.136 and an adjusted p-value of 0.01485. Which disease is associated with this specific gene? | cervical cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03951","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A upregulates a gene that is located in the extracellular space. In a study of cervical adenocarcinoma cell line... | |
medium_hidden_intermediate_03952 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and binds to RBBP7. Transcriptomic data for this gene reports a log2 fold change of approximately 10.47 and an adjusted p-value of 0.0053. Which protein is encoded by this gene? | Methyl-CpG-binding domain protein 3-like 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03952","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and binds to RBBP7. Transcriptomic data for t... | |
medium_hidden_intermediate_03953 | Human immunodeficiency virus 1 downregulates a gene that is involved in microtubule cytoskeleton organization. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of -1.868 and an adjusted p-value of 0.01359. Which molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03953","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is involved in microtubule cytoskeleton organization. In a study of... | |
medium_hidden_intermediate_03955 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene, the product of which is located in the perinuclear region of the cytoplasm. This gene exhibited a log2 fold change of approximately 1.56 and an adjusted p-value of 0.002027. Which protein is encoded by thi... | Ras-related protein Rab-15 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03955","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene, the produ... | |
medium_hidden_intermediate_03956 | Rift Valley fever phlebovirus upregulates a gene that participates in Class A/1 (Rhodopsin-like receptors). In a study of SAEC cells (GSE102481), one such upregulated gene showed a log2 fold change of approximately 2.85 and an adjusted p-value of 0.0064. Which cellular component is this specific gene located in? | extracellular space | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03956","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rift Valley fever phlebovirus upregulates a gene that participates in Class A/1 (Rhodopsin-like receptors). In a study of SA... | |
medium_hidden_intermediate_03957 | Two genes are each upregulated by Severe acute respiratory syndrome-related coronavirus and associated with teratoma. One of these genes was reported in a study of lung cells (GSE155241) with a log2 fold change of approximately 2.78 and an adjusted p-value of 0.0232. Which cellular component is the location of this spe... | membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03957","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each upregulated by Severe acute respiratory syndrome-related coronavirus and associated with teratoma. One of... | |
medium_hidden_intermediate_03961 | Vaccinia virus upregulates a gene that is involved in the positive regulation of cell population proliferation. Evidence for this gene in a specific study reports a log2 fold change of approximately 2.25 and an adjusted p-value of approximately 6.16e-09. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03961","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a gene that is involved in the positive regulation of cell population proliferation. Evidence for... | |
medium_hidden_intermediate_03964 | Zika virus downregulates a specific gene that participates in apoptosis. Transcriptomic data from study GSE114907 indicates this gene has a log2 fold change of approximately -1.76 and an adjusted p-value of 0.0085 in glioma stem cells. In which cell type is this gene enriched? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03964","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in apoptosis. Transcriptomic data from study GSE114907 indicates ... | |
medium_hidden_intermediate_03966 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with RAF1. Evidence for one such gene reports a log2 fold change of 1.710 and an adjusted p-value of 0.014. In which cell type is this gene enriched? | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03966","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with RAF1. Evidence for one such gen... | |
medium_hidden_intermediate_03967 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is downregulated by the virus and is enriched in neutrophils. This gene exhibits a log2 fold change of approximately -2.17 and an adjusted p-value of 0.0039. Which biological process is this gene involved in? | positive regulation of granulocyte differentiation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03967","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is downregulated by ... | |
medium_hidden_intermediate_03968 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with melanoma. One of these genes exhibits a log2 fold change of 1.136 and an adjusted p-value of 0.001045 in a specific study. Which cellular component is the location of this specific gene? | mitochondrion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03968","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with melanoma. One of ... | |
medium_hidden_intermediate_03969 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the G2/M transition of the mitotic cell cycle. One of these genes was reported in a study on cardiomyocyte cell lines (GSE151879) with a log2 fold change of approximately 1.32 and an adjusted p-value of 0.00602. Which... | Serine/threonine-protein kinase BRSK1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03969","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the G2/M transition o... | |
medium_hidden_intermediate_03971 | ACTBL2 interacts with a protein that serves as a biomarker for alcohol abuse. Evidence regarding one such interacting protein notes that SNPs in the gene encoding this protein were among those most strongly implicated in bipolar alcoholism, although they did not meet conventional genome-wide significance criteria. Whic... | teratocarcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03971","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"ACTBL2 interacts with a protein that serves as a biomarker for alcohol abuse. Evidence regarding one such interacting protei... | |
medium_hidden_intermediate_03974 | Zika virus downregulates a gene that participates in the mitotic cell cycle. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -1.043 and an adjusted p-value of 0.03418. Which protein is encoded by this gene? | Nuclear envelope phosphatase-regulatory subunit 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03974","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in the mitotic cell cycle. In a study of glioma stem cells (GSE114907), th... | |
medium_hidden_intermediate_03975 | Zika virus downregulates a gene that is involved in endocytosis during viral entry into host cells. Experimental data from glioma stem cells (study GSE114907) indicates that this specific gene has a log2 fold change of approximately -1.65 and an adjusted p-value of approximately 0.0155. Which protein is encoded by this... | Two pore channel protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03975","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in endocytosis during viral entry into host cells. Experimental data from g... | |
medium_hidden_intermediate_03976 | Cardiovirus A downregulates a gene that is enriched in non-classical monocytes. Evidence for one such gene reports a log2 fold change of -1.376 and an adjusted p-value of 0.02396. Which protein is encoded by that gene? | Zinc finger protein 25 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03976","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A downregulates a gene that is enriched in non-classical monocytes. Evidence for one such gene reports a log2 fo... | |
medium_hidden_intermediate_03977 | A gene is upregulated by Human gammaherpesvirus 8 and is involved in the pyroptotic inflammatory response. Experimental data for this gene reports a log2 fold change of approximately 2.38 and an adjusted p-value of approximately 0.0057. Which disease is associated with this gene through genomic alterations? | gastric carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03977","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human gammaherpesvirus 8 and is involved in the pyroptotic inflammatory response. Experimental data... | |
medium_hidden_intermediate_03980 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the ephrin receptor signaling pathway. Evidence for this specific gene reports a log2 fold change of 1.905 and an adjusted p-value of 0.03029. Which protein is encoded by this gene? | Ephrin-A3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03980","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the ephrin receptor signaling p... | |
medium_hidden_intermediate_03981 | Zika virus downregulates a gene that is located in the lysosomal membrane. Evidence for this gene reports a log2 fold change of -2.297 and an adjusted p-value of 0.003988. Which protein is encoded by this gene? | Solute carrier family 35 member F6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03981","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in the lysosomal membrane. Evidence for this gene reports a log2 fold change... | |
medium_hidden_intermediate_03982 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene that enables sequence-specific double-stranded DNA binding. This specific gene exhibited a log2 fold change of approximately 5.84 and an adjusted p-value of 0.00037. Which protein is encoded by this gene... | Class A basic helix-loop-helix protein 15 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03982","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene that en... | |
medium_hidden_intermediate_03983 | A gene is upregulated by Vaccinia virus and localized to the perinuclear region of the cytoplasm. Transcriptomic data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of 2.765 and an adjusted p-value of 6.855e-15. Which disease is associated with this gene? | Al-Raqad syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03983","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Vaccinia virus and localized to the perinuclear region of the cytoplasm. Transcriptomic data for th... | |
medium_hidden_intermediate_03987 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and involved in protein localization was found to have a log2 fold change of 2.702 and an adjusted p-value of 0.0001295. Which disease is associated with this gene as a biomarker? | ACTH-independent Cushing syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03987","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and involved in protein lo... | |
medium_hidden_intermediate_03988 | Hepacivirus C is reported to downregulate a gene that is enriched in classical monocytes. Evidence for one such gene shows a log2 fold change of -1.021 and an adjusted p-value of 0.0001286. Which protein is encoded by this gene? | Folate receptor beta | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03988","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that is enriched in classical monocytes. Evidence for one such gene shows a... | |
medium_hidden_intermediate_03989 | In a study of pancreatic cell lines (GSE151803), Severe acute respiratory syndrome-related coronavirus was found to downregulate a specific gene, which in turn interacts with FGFR1. This gene exhibited a log2 fold change of approximately -1.08 and an adjusted p-value of 0.0148. Which biological process is this gene inv... | positive regulation of membrane protein ectodomain proteolysis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03989","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pancreatic cell lines (GSE151803), Severe acute respiratory syndrome-related coronavirus was found to downregu... | |
medium_hidden_intermediate_03990 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Phase 1 - inactivation of fast Na+ channels. Evidence for one such gene reports a log2 fold change of 2.601 and an adjusted p-value of 4.187e-06. Which protein is encoded by that gene? | A-type voltage-gated potassium channel KCND1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03990","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Phase 1 - inactivation of fast... | |
medium_hidden_intermediate_03994 | Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' interaction and to NCBP2 via a 'binds' interaction. One of these genes is reported in study GSE108897 with a log2 fold change of -1.786 and an adjusted p-value of 0.006225. Which cell type is this specific gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03994","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' interaction and to NCBP2 via a 'bi... | |
medium_hidden_intermediate_03995 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with hyperlipidemia. One of these genes shows a log2 fold change of 1.415 and an adjusted p-value of 0.02364 in a specific study. Which cell type is enriched for this specific gene? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03995","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with hyperlipidemia. O... | |
medium_hidden_intermediate_03996 | A gene serves as a marker for endothelial cells and is enriched in eosinophils. Evidence for one such gene reports a mean expression of 58.59 TPM, a z-score of 2.31, and a fold enrichment of 8.03. Which disease is associated with this gene as a biomarker? | lung carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03996","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for endothelial cells and is enriched in eosinophils. Evidence for one such gene reports a mean ex... | |
medium_hidden_intermediate_03997 | Two genes are structurally linked to Cardiovirus A via a downregulation relationship and to the lysosomal membrane via a location relationship. One of these genes has an associated log2 fold change of approximately -1.007 and an adjusted p-value of 0.02776 in cervical adenocarcinoma cell lines. Which disease is associa... | spastic paraplegia 87, autosomal recessive | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03997","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Cardiovirus A via a downregulation relationship and to the lysosomal membrane via a loc... | |
medium_hidden_intermediate_03998 | A gene is upregulated by Primate bocaparvovirus 1 and its product is located in the membrane. Transcriptomic data for this gene in tracheobronchial epithelial cells shows a log2 fold change of 1.418 and an adjusted p-value of 0.03579. Which protein is encoded by this gene? | Squalene monooxygenase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_03998","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and its product is located in the membrane. Transcriptomic data for this g... | |
medium_hidden_intermediate_04000 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which in turn participates in platelet degranulation. This gene exhibits a log2 fold change of -1.885 and an adjusted p-value of 0.01713. Which protein is encoded by this gene? | Phosphatase and actin regulator 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04000","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_04001 | Vaccinia virus upregulates a gene that is associated with gastric adenocarcinoma. One such gene exhibits a log2 fold change of 2.804 and an adjusted p-value of 2.274e-10 in cervical adenocarcinoma cell lines (study GSE11238). Which protein is encoded by this gene? | Protein CIP2A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04001","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a gene that is associated with gastric adenocarcinoma. One such gene exhibits a log2 fold change ... | |
medium_hidden_intermediate_04002 | In studies of Severe acute respiratory syndrome-related coronavirus infection, certain genes are upregulated and their products are located in the Golgi membrane. One such gene exhibits a log2 fold change of approximately 3.54 and an adjusted p-value of 0.0159. Which protein is encoded by this specific gene? | ATP-binding cassette sub-family A member 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04002","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In studies of Severe acute respiratory syndrome-related coronavirus infection, certain genes are upregulated and their produ... | |
medium_hidden_intermediate_04003 | Vaccinia virus upregulates a gene that participates in Signaling by Rho GTPases. In a study of cervical adenocarcinoma cell lines (GSE11238), one such gene exhibits a log2 fold change of approximately 1.865 and an adjusted p-value of 2.607e-08. Which protein interacts with this specific gene product? | PXN | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04003","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a gene that participates in Signaling by Rho GTPases. In a study of cervical adenocarcinoma cell ... | |
medium_hidden_intermediate_04004 | Zika virus downregulates a gene that interacts with SEC62. Experimental data for this gene in glioma stem cells (study GSE114907) shows a log2 fold change of approximately -1.129 and an adjusted p-value of 0.03398. Which protein is encoded by this gene? | Stromal interaction molecule 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04004","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with SEC62. Experimental data for this gene in glioma stem cells (study GSE11... | |
medium_hidden_intermediate_04006 | Posaconazole and Gilteritinib are linked via a shared interacting partner. Clinical evidence highlights that this partner, along with agents such as acalabrutinib, dasatinib, and imatinib, poses significant risks when co-administered with posaconazole due to reduced clearance or QTc prolongation. Which disease is this ... | mantle cell lymphoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04006","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Posaconazole and Gilteritinib are linked via a shared interacting partner. Clinical evidence highlights that this partner, a... | |
medium_hidden_intermediate_04009 | In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene upregulated by Human gammaherpesvirus 8 and involved in Signaling by Interleukins showed a log2 fold change of approximately 1.01 and an adjusted p-value of 0.0179. Which protein does this gene product bind to? | SLC22A17 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04009","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene upregulated by Human gammaherpesvirus 8 and involved in Si... | |
medium_hidden_intermediate_04010 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a downregulation relationship and to nonsyndromic genetic hearing loss via an association. One of these genes was reported in a study (GSE151803) using a pancreatic cell line, showing a log2 fold change of approximately -2.05... | protein repair | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04010","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a downregulation relationship... | |
medium_hidden_intermediate_04012 | Zika virus downregulates a gene that participates in GPCR downstream signalling. In glioma stem cells, one such gene exhibits a log2 fold change of -2.578 and an adjusted p-value of 0.01212. Which protein is encoded by this gene? | Neuropeptide Y receptor type 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04012","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in GPCR downstream signalling. In glioma stem cells, one such gene exhibit... | |
medium_hidden_intermediate_04013 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables ATP binding. Experimental data for this gene in bronchial epithelial cells from study GSE150819 shows a log2 fold change of approximately -5.73 and an adjusted p-value of 0.009. Which disease is associated with this gene? | anencephaly 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04013","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables ATP binding. Experimental data ... | |
medium_hidden_intermediate_04014 | Two genes are structurally linked from Pegivirus C via a downregulation relationship and subsequently to RHO GTPase Effectors via a participation relationship. One of these genes exhibits a log2 fold change of -2.073 and an adjusted p-value of 0.0005581 in peripheral blood mononuclear cells (study GSE131504). Which dis... | Hereditary factor VIII deficiency disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04014","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Pegivirus C via a downregulation relationship and subsequently to RHO GTPase Effector... | |
medium_hidden_intermediate_04017 | Two genes are upregulated by Vaccinia virus and interact with SOD1. One of these genes shows a log2 fold change of 2.601 and an adjusted p-value of 2.106e-13 in cervical adenocarcinoma cell lines. Which disease is associated with this specific gene as a biomarker? | heart failure | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04017","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and interact with SOD1. One of these genes shows a log2 fold change of 2.601 and... | |
medium_hidden_intermediate_04019 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Glycosaminoglycan metabolism. Experimental data for this gene shows a log2 fold change of -1.065 and an adjusted p-value of 0.03. Which disease is associated with this gene? | plasma cell myeloma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04019","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Glycosaminoglycan metab... | |
medium_hidden_intermediate_04020 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the Intrinsic Pathway for Apoptosis. One of these genes was reported in a study using SAEC cells (GSE153218) with a log2 fold change of approximately 1.708 and an adjusted p-value of 0.04425. Which protein does this sp... | DYNLL2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04020","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the Intrinsic Pathway ... | |
medium_hidden_intermediate_04021 | Zika virus downregulates a specific gene that participates in the MyD88-dependent cascade initiated on the endosome. Experimental data from glioma stem cells (study GSE114907) indicate that this gene has a log2 fold change of approximately -1.05 and an adjusted p-value of 0.011. Which disease is associated with this ge... | squamous cell intraepithelial neoplasia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04021","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in the MyD88-dependent cascade initiated on the endosome. Experim... | |
medium_hidden_intermediate_04022 | Zaire ebolavirus downregulates a gene that participates in Membrane Trafficking. In a study of retinal pigment epithelium cells (GSE100839), one such gene showed a log2 fold change of approximately -1.13 and an adjusted p-value of 0.0054. Which protein does this specific gene interact with? | MAP1LC3A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04022","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus downregulates a gene that participates in Membrane Trafficking. In a study of retinal pigment epithelium ce... | |
medium_hidden_intermediate_04023 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus was found to downregulate a specific gene, which in turn binds to CTNNAL1. The expression data for this intermediate gene shows a log2 fold change of approximately -1.345 and an adjusted p-value of 0.01456. Which protein is encoded by this inte... | Cadherin-8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04023","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus was found to downregulate a specific gene, which... | |
medium_hidden_intermediate_04025 | Human betaherpesvirus 5 upregulates a gene that enables identical protein binding. Evidence for this gene reports a log2 fold change of 2.038 and an adjusted p-value of 0.003808. Which cell type is this gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04025","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that enables identical protein binding. Evidence for this gene reports a log2 fol... | |
medium_hidden_intermediate_04028 | Zika virus downregulates a gene that is involved in the regulation of DNA-templated transcription. Experimental data from glioma stem cells (study GSE114907) reports a log2 fold change of -1.939 and an adjusted p-value of 0.009909 for this gene. Which protein is encoded by this gene? | Zinc finger protein with KRAB and SCAN domains 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04028","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the regulation of DNA-templated transcription. Experimental data from gl... | |
medium_hidden_intermediate_04029 | A gene serves as a marker for Dendritic cells and is enriched in Conventional dendritic cells. Evidence for this gene includes a mean expression of 59.53 TPM, a z-score of 2.51, and a fold enrichment of 10.09. Which disease is associated with this gene? | leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04029","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for Dendritic cells and is enriched in Conventional dendritic cells. Evidence for this gene includ... | |
medium_hidden_intermediate_04030 | Two genes are structurally linked from Human betaherpesvirus 5 via a 'downregulates' relationship and subsequently to Eosinophil via an 'enriched in' relationship. One of these genes has been reported in a study (GSE130665) using foreskin fibroblast cell lines, showing a log2 fold change of approximately -1.05 and an a... | myeloid leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04030","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Human betaherpesvirus 5 via a 'downregulates' relationship and subsequently to Eosino... | |
medium_hidden_intermediate_04031 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a specific gene that enables small GTPase binding. This gene exhibited a log2 fold change of 2.136 and an adjusted p-value of 1.923e-14. Which cellular component is this gene located in? | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04031","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a specific gene tha... | |
medium_hidden_intermediate_04032 | In a study of Influenza A virus infection, a specific gene is upregulated and subsequently associated with lung carcinoma. Experimental data for this gene reports a log2 fold change of approximately 1.666 and an adjusted p-value of 0.0001722. Which protein is encoded by this gene? | Angiopoietin-related protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04032","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is upregulated and subsequently associated with lung carcinoma. E... | |
medium_hidden_intermediate_04034 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with RAF1. Evidence for one such gene reports a log2 fold change of 1.032 and an adjusted p-value of 1.381e-06. Which protein is encoded by that gene? | Leucine-rich repeat-containing protein 59 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04034","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with RAF1. Evidence for one such gen... | |
medium_hidden_intermediate_04035 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and its protein product binds to UTP6. One such gene exhibits a log2 fold change of 2.130 and an adjusted p-value of 6.049e-10. Which protein is encoded by this specific gene? | Ribosomal RNA processing protein 36 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04035","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and its protein product... | |
medium_hidden_intermediate_04037 | Two genes are each downregulated by Human betaherpesvirus 5 and serve as biomarkers for diabetic kidney disease. One of these genes was reported in a study (GSE111036) using foreskin fibroblast cell lines, with a log2 fold change of approximately -1.045 and an adjusted p-value of 0.04594. Which protein does this specif... | RHOB | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04037","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each downregulated by Human betaherpesvirus 5 and serve as biomarkers for diabetic kidney disease. One of thes... | |
medium_hidden_intermediate_04038 | Pegivirus C is reported to downregulate a gene that is involved in the positive regulation of mitochondrial fusion. Transcriptomic data from peripheral blood mononuclear cells (study GSE131504) indicates that one such gene has a log2 fold change of approximately -1.095 and an adjusted p-value of 0.003127. Which disease... | optic atrophy 14 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04038","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in the positive regulation of mitochondrial fusion. Transcri... | |
medium_hidden_intermediate_04039 | Human alphaherpesvirus 3 is reported to upregulate a gene that is enriched in conventional dendritic cells. Evidence for one such gene in a melanoma cell line (study GSE136586) shows a log2 fold change of 1.153 and an adjusted p-value of 5.646e-11. Which protein is encoded by this specific gene? | Cytosol aminopeptidase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04039","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 is reported to upregulate a gene that is enriched in conventional dendritic cells. Evidence for one... | |
medium_hidden_intermediate_04041 | Identify the protein encoded by the gene that satisfies the following criteria: (1) It is connected to CRYAA via an 'interacts with' relationship and to 'protein binding' via an 'enables' relationship. (2) Experimental evidence indicates that this protein (also known as a small heat shock protein) interacts with HSP22,... | Heat shock protein beta-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04041","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Identify the protein encoded by the gene that satisfies the following criteria: (1) It is connected to CRYAA via an 'interac... | |
medium_hidden_intermediate_04042 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Glutathione synthesis and recycling. Evidence for one such gene reports a log2 fold change of approximately 1.004 and an adjusted p-value of 0.009185. Which molecular function is enabled by that specific gene? | glutathione specific gamma-glutamylcyclotransferase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04042","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Glutathione synthesis and recy... | |
medium_hidden_intermediate_04043 | A gene is downregulated by Human gammaherpesvirus 8 and is enriched in basophils. Experimental data for this gene reports a log2 fold change of approximately -1.166 and an adjusted p-value of 0.03055. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04043","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Human gammaherpesvirus 8 and is enriched in basophils. Experimental data for this gene reports a ... |
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