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medium_hidden_intermediate_04044 | Hepacivirus C is reported to downregulate a specific gene that participates in the G0 and Early G1 phases of the cell cycle. Experimental evidence for this gene shows a log2 fold change of -1.101 and an adjusted p-value of 1.883e-06. Which disease is associated with genomic alterations in this gene? | hepatocellular carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04044","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a specific gene that participates in the G0 and Early G1 phases of the cell cycle.... | |
medium_hidden_intermediate_04046 | Zika virus downregulates a gene that participates in the M Phase. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -1.88 and an adjusted p-value of 0.0194. Which protein is encoded by this gene? | Separin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04046","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in the M Phase. In a study of glioma stem cells (GSE114907), this gene exh... | |
medium_hidden_intermediate_04048 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate certain genes that are involved in the negative regulation of transcription by RNA polymerase II. One such gene exhibited a log2 fold change of 1.310 and an adjusted p-value of 0.01176. Which protein is encoded by this spe... | Zinc finger protein 589 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04048","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate certain genes that are inv... | |
medium_hidden_intermediate_04050 | In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to downregulate a specific gene, which in turn interacts with PPP2R2A. The downregulation of this gene is characterized by a log2 fold change of -1.446 and an adjusted p-value of 0.000386. Which protein ... | Cell division cycle-associated protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04050","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to down... | |
medium_hidden_intermediate_04051 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and located in chromatin. Evidence for this gene reports a log2 fold change of 3.369 and an adjusted p-value of 0.001632. Which biological process is this gene involved in? | positive regulation of transcription by RNA polymerase II | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04051","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and located in chromatin. Evidence for this g... | |
medium_hidden_intermediate_04052 | Human immunodeficiency virus 1 upregulates a gene that participates in Signaling by Rho GTPases. Evidence for this gene in macrophages (study GSE108897) reports a log2 fold change of approximately 2.56 and an adjusted p-value of 0.0012. Which biological process is this gene involved in? | signal transduction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04052","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in Signaling by Rho GTPases. Evidence for this gene in m... | |
medium_hidden_intermediate_04053 | A gene is upregulated by Primate bocaparvovirus 1 and enables RNA binding. Experimental data for this gene reports a log2 fold change of 2.590 and an adjusted p-value of 0.03562. Which cellular component is this gene located in? | trans-Golgi network | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04053","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and enables RNA binding. Experimental data for this gene reports a log2 fo... | |
medium_hidden_intermediate_04055 | Zika virus infection upregulates certain genes that participate in G alpha (q) signalling events. In a study of neural stem cells (GSE129180), one such gene showed a log2 fold change of 1.696 and an adjusted p-value of 0.01464. Which protein is encoded by this specific gene? | Proteinase-activated receptor 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04055","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection upregulates certain genes that participate in G alpha (q) signalling events. In a study of neural stem ... | |
medium_hidden_intermediate_04056 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to RPS19 via a binding relationship. One of these genes is reported in a study (GSE148729) involving a colonic adenocarcinoma cell line, with a log2 fold change of approximately 1.555 and an a... | ectopic pregnancy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04056","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship ... | |
medium_hidden_intermediate_04057 | Two genes are structurally linked to Measles morbillivirus via an 'upregulates' relationship and to YWHAG via an 'interacts with' relationship. One of these genes is associated with experimental data showing a log2 fold change of approximately 1.036 and an adjusted p-value of approximately 0.00087. Which cell type is t... | gamma-delta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04057","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Measles morbillivirus via an 'upregulates' relationship and to YWHAG via an 'interacts ... | |
medium_hidden_intermediate_04060 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of certain genes that are localized to the endosome. One such gene exhibits a log2 fold change of approximately 1.499 and an adjusted p-value of 0.00957. Which biological process is this specific gene involved in? | vesicle organization | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04060","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of certain genes that ar... | |
medium_hidden_intermediate_04061 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to FOXP2 via an interaction relationship. One of these genes was reported in a study with a log2 fold change of approximately 1.002 and an adjusted p-value of 0.01899. Which biological process... | negative regulation of DNA-templated transcription | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04061","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship ... | |
medium_hidden_intermediate_04062 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in turn interacts with YWHAB. This gene exhibited a log2 fold change of -2.330 and an adjusted p-value of 0.006067. Which protein is encoded by this gene? | Oxysterol-binding protein-related protein 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04062","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in tu... | |
medium_hidden_intermediate_04063 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in endothelial cell migration. Experimental data for this gene reports a log2 fold change of approximately 1.094 and an adjusted p-value of 0.02524. Which disease is associated with this gene? | neuroblastoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04063","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in endothelial cell migration... | |
medium_hidden_intermediate_04069 | Human betaherpesvirus 5 is reported to downregulate a gene that subsequently interacts with CCNF. In a study of foreskin fibroblast cell lines (GSE111036), one such intermediate gene exhibits a log2 fold change of -1.285 and an adjusted p-value of 0.04705. Which protein is encoded by this specific gene? | Tyrosine-protein phosphatase non-receptor type 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04069","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that subsequently interacts with CCNF. In a study of foreskin fib... | |
medium_hidden_intermediate_04070 | Two genes are upregulated by Human immunodeficiency virus 1 and participate in the transport of small molecules. One of these genes exhibits a log2 fold change of approximately 1.95 and an adjusted p-value of 0.0058 in macrophages. Which cell type is enriched for this specific gene? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04070","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and participate in the transport of small molecules. One of thes... | |
medium_hidden_intermediate_04071 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a gene that enables sequence-specific double-stranded DNA binding. One such gene exhibited a log2 fold change of approximately 1.256 and an adjusted p-value of 0.01792. Which protein is encoded by this specific gene? | Homeobox protein Hox-A7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04071","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a gene that enables sequen... | |
medium_hidden_intermediate_04072 | A gene is upregulated by Measles morbillivirus and enriched in naive B cells. Experimental data for this gene reports a log2 fold change of approximately 1.19 and an adjusted p-value of 0.0252. Which protein does this gene product interact with? | FBXW7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04072","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and enriched in naive B cells. Experimental data for this gene reports a log2... | |
medium_hidden_intermediate_04073 | A gene is upregulated by Measles morbillivirus and participates in the Adaptive Immune System. Experimental data for this gene reports a log2 fold change of approximately 1.30 and an adjusted p-value of 0.016. Which disease is associated with this gene as a biomarker? | digestive system neuroendocrine tumor, grade 1/2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04073","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and participates in the Adaptive Immune System. Experimental data for this ge... | |
medium_hidden_intermediate_04074 | Human immunodeficiency virus 1 downregulates a gene that enables enzyme binding. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of approximately -1.18 and an adjusted p-value of approximately 0.022. Which disease is associated with this gene? | lung sarcomatoid carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04074","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that enables enzyme binding. Evidence for this gene in macrophages (from... | |
medium_hidden_intermediate_04075 | Rift Valley fever phlebovirus upregulates a gene that is located in the cytoplasm. In a study using SAEC cells (GSE102481), one such gene showed a log2 fold change of 1.966 and an adjusted p-value of 0.005678. Which disease is associated with this specific gene? | prostate cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04075","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rift Valley fever phlebovirus upregulates a gene that is located in the cytoplasm. In a study using SAEC cells (GSE102481), ... | |
medium_hidden_intermediate_04076 | In the context of Measles morbillivirus infection, two genes are known to be upregulated by the virus and to interact with the protein YWHAZ. One of these genes exhibits a log2 fold change of 2.172 and an adjusted p-value of 0.02612 in study GSE131840. Which protein is encoded by this specific gene? | Tyrosine-protein kinase ABL2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04076","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In the context of Measles morbillivirus infection, two genes are known to be upregulated by the virus and to interact with t... | |
medium_hidden_intermediate_04077 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and subsequently interacts with CCNT1. Evidence for this gene reports a log2 fold change of approximately 1.353 and an adjusted p-value of 0.01047. Which protein is encoded by this gene? | Aryl hydrocarbon receptor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04077","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and subsequent... | |
medium_hidden_intermediate_04078 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific gene that enables histone H3K4me3 reader activity. This gene exhibited a log2 fold change of -2.377 and an adjusted p-value of 0.0106. Which protein is encoded by this gene? | MORC family CW-type zinc finger protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04078","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific g... | |
medium_hidden_intermediate_04081 | Zika virus downregulates a gene that enables histone H3K4me3 reader activity. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -2.044 and an adjusted p-value of 0.01288. Which protein is encoded by this gene? | Inhibitor of growth protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04081","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that enables histone H3K4me3 reader activity. In a study of glioma stem cells (GSE114907), o... | |
medium_hidden_intermediate_04082 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and interacts with SRC. Experimental data for this gene reports a log2 fold change of -3.853 and an adjusted p-value of 0.01434. Which protein is encoded by this gene? | Protein TAMALIN | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04082","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and interacts with SRC. Experimental data f... | |
medium_hidden_intermediate_04085 | Zika virus downregulates a specific gene that is associated with hepatocellular carcinoma. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -1.319 and an adjusted p-value of 0.03439. Which protein is encoded by this gene? | Tetraspanin-4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04085","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is associated with hepatocellular carcinoma. In a study of glioma stem cells (... | |
medium_hidden_intermediate_04087 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with NDEL1. One of these genes exhibits a log2 fold change of approximately 1.307 and an adjusted p-value of 0.001539 in a specific study. Which protein is encoded by this gene? | Katanin p80 WD40 repeat-containing subunit B1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04087","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with NDEL1. One of these gen... | |
medium_hidden_intermediate_04088 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables signaling receptor activity. Experimental data for this gene reports a log2 fold change of -1.031 and an adjusted p-value of 0.01756. Which protein is encoded by this gene? | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04088","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables signaling receptor activity. Ex... | |
medium_hidden_intermediate_04089 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that enables DNA-binding transcription factor activity. One such gene exhibited a log2 fold change of -1.329 and an adjusted p-value of 0.004778. Which protein is encoded by this specific gene? | Forkhead box protein N2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04089","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that enables DNA-bind... | |
medium_hidden_intermediate_04090 | Two genes are downregulated by Pegivirus C and are associated with neuroblastoma. One of these genes exhibits a log2 fold change of -2.614 and an adjusted p-value of 0.006038 in peripheral blood mononuclear cells (study GSE131504). What molecular function is enabled by this specific gene? | RNA binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04090","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and are associated with neuroblastoma. One of these genes exhibits a log2 fold ch... | |
medium_hidden_intermediate_04091 | In a study of stomach cells (GSE153684), Severe acute respiratory syndrome-related coronavirus was found to downregulate a specific gene, which is associated with arthropathy. The expression data for this gene shows a log2 fold change of -1.308 and an adjusted p-value of 4.208e-08. Which protein is encoded by this gene... | Tumor necrosis factor receptor superfamily member 21 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04091","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of stomach cells (GSE153684), Severe acute respiratory syndrome-related coronavirus was found to downregulate a s... | |
medium_hidden_intermediate_04092 | Cardiovirus A infection leads to the upregulation of certain genes whose protein products are located in the extracellular space. In a study of cervical adenocarcinoma cell lines (GSE122967), one such upregulated gene exhibited a log2 fold change of approximately 1.188 and an adjusted p-value of 0.0102. Which protein i... | Lysyl oxidase homolog 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04092","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A infection leads to the upregulation of certain genes whose protein products are located in the extracellular s... | |
medium_hidden_intermediate_04093 | Hepacivirus C upregulates a gene that is located in the cytosol. Evidence for one such gene reports a log2 fold change of 1.391 and an adjusted p-value of 0.0006516. Which cell type is this gene enriched in? | conventional dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04093","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is located in the cytosol. Evidence for one such gene reports a log2 fold change of 1.... | |
medium_hidden_intermediate_04095 | Human alphaherpesvirus 1 upregulates a gene that is enriched in non-classical monocytes. Evidence for this gene reports a log2 fold change of 1.205 and an adjusted p-value of 0.003552. Which protein is encoded by this gene? | Protease-associated domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04095","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that is enriched in non-classical monocytes. Evidence for this gene reports a lo... | |
medium_hidden_intermediate_04096 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and its protein product interacts with OFD1. Evidence for this gene reports a log2 fold change of -1.557 and an adjusted p-value of 0.02083. Which protein is encoded by this gene? | Lebercilin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04096","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and its prot... | |
medium_hidden_intermediate_04097 | Hepacivirus C is reported to downregulate a gene that enables receptor ligand activity. In a study of peripheral blood mononuclear cells (GSE119117), one such gene exhibited a log2 fold change of -1.655 and an adjusted p-value of 0.01548. Which protein is encoded by this specific gene? | Semaphorin-3E | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04097","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that enables receptor ligand activity. In a study of peripheral blood monon... | |
medium_hidden_intermediate_04098 | In a study of Hepacivirus C infection in hepatocytes (GSE132606), a specific gene is upregulated by the virus and enables sulfotransferase activity. This gene exhibits a log2 fold change of 2.269 and an adjusted p-value of 0.0154. Which protein is encoded by this gene? | Sulfotransferase 1A4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04098","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Hepacivirus C infection in hepatocytes (GSE132606), a specific gene is upregulated by the virus and enables su... | |
medium_hidden_intermediate_04099 | In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and associated with breast cancer through genomic alterations. This specific gene exhibits a log2 fold change of 5.976 and an adjusted p-value of 0.005878. Which protein is encoded by this gene? | Insulin-like growth factor-binding protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04099","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and associated with breast ca... | |
medium_hidden_intermediate_04100 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and to GFRA2 via a 'binds' relationship. One of these genes is associated with experimental data showing a log2 fold change of approximately 1.163 and an adjusted p-value of 0.0009587. Which prot... | Docking protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04100","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship... | |
medium_hidden_intermediate_04101 | Two genes are upregulated by Vaccinia virus and serve as biomarkers for lung cancer. One of these genes exhibits a log2 fold change of 1.544 and an adjusted p-value of 1.041e-10 in cervical adenocarcinoma cell lines (study GSE11238). Which biological process is this specific gene involved in? | ceramide biosynthetic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04101","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and serve as biomarkers for lung cancer. One of these genes exhibits a log2 fold... | |
medium_hidden_intermediate_04102 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that is involved in the response to unfolded protein. This specific gene exhibited a log2 fold change of -1.344 and an adjusted p-value of 0.001951. Which protein is encoded by this gene? | DnaJ homolog subfamily B member 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04102","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that is involved in t... | |
medium_hidden_intermediate_04103 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables ubiquitin protein ligase binding. Transcriptomic data for this gene in a specific study reports a log2 fold change of 1.047 and an adjusted p-value of 0.008506. Which protein is encoded by this gene? | Tyrosine-protein phosphatase non-receptor type 22 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04103","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables ubiquitin protein ligase binding.... | |
medium_hidden_intermediate_04104 | Zika virus downregulates a gene that participates in Glycosaminoglycan metabolism. Evidence for this specific gene reports a log2 fold change of -1.849 and an adjusted p-value of 0.01144. Which molecular function is enabled by this gene? | 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04104","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in Glycosaminoglycan metabolism. Evidence for this specific gene reports a... | |
medium_hidden_intermediate_04105 | Human polyomavirus 1 is reported to upregulate a gene that is enriched in classical monocytes. Evidence for this specific gene in renal epithelial cells shows a log2 fold change of 2.166 and an adjusted p-value of 0.007037. Which protein is encoded by this gene? | Palmitoyltransferase ZDHHC7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04105","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human polyomavirus 1 is reported to upregulate a gene that is enriched in classical monocytes. Evidence for this specific ge... | |
medium_hidden_intermediate_04106 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and interacts with PRKN. Experimental data for this gene shows a log2 fold change of -1.272 and an adjusted p-value of 0.0009462. Which biological process is this gene involved in? | epithelial cell differentiation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04106","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and interacts with PRKN. Experimental data ... | |
medium_hidden_intermediate_04107 | Human alphaherpesvirus 1 upregulates a specific gene product that participates in the recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks. In a study of monocytic leukemia cell lines (GSE114966), this entity was found to have a log2 fold change of 2.124 and an adjus... | Histone H2B type 1-C/E/F/G/I | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04107","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a specific gene product that participates in the recruitment and ATM-mediated phosphory... | |
medium_hidden_intermediate_04108 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in brain development. Evidence for one such gene reports a log2 fold change of -1.501 and an adjusted p-value of 0.0009268. Which protein is encoded by that gene? | Neuronatin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04108","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in brain development. Evidence f... | |
medium_hidden_intermediate_04109 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and to SDCCAG8 via a 'binds' relationship. One of these genes is associated with experimental data showing a log2 fold change of approximately 1.054 and an adjusted p-value of 0.04046. Which prot... | Protein aurora borealis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04109","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship... | |
medium_hidden_intermediate_04111 | Two genes are downregulated by Vaccinia virus and participate in Signaling by Rho GTPases, Miro GTPases and RHOBTB3. One of these genes exhibits a log2 fold change of -1.485 and an adjusted p-value of 0.0006996 in cervical adenocarcinoma cell lines. Which cell type is enriched for this specific gene? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04111","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Vaccinia virus and participate in Signaling by Rho GTPases, Miro GTPases and RHOBTB3. One of ... | |
medium_hidden_intermediate_04112 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which in turn interacts with the protein CANX. This gene exhibits a log2 fold change of -1.498 and an adjusted p-value of 0.01951. Which protein is encoded by this downregulated gene? | Glucoside xylosyltransferase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04112","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_04113 | Two genes are upregulated by Vaccinia virus and serve as biomarkers for breast carcinoma. One of these genes exhibits a log2 fold change of 2.135 and an adjusted p-value of 1.471e-06 in a specific study. Which cell type is enriched for this specific gene? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04113","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and serve as biomarkers for breast carcinoma. One of these genes exhibits a log2... | |
medium_hidden_intermediate_04115 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that subsequently binds to HSP90AA1. One such gene exhibits a log2 fold change of 1.245 and an adjusted p-value of 0.005132. Which protein is encoded by this specific gene? | Dedicator of cytokinesis protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04115","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that subsequently binds to HSP90AA1... | |
medium_hidden_intermediate_04116 | In a study of glioma stem cells (GSE114907), Zika virus infection was found to downregulate a specific gene, which in turn interacts with RB1. This gene exhibited a log2 fold change of -1.724 and an adjusted p-value of 0.01501. Which protein is encoded by this gene? | Zinc finger and BTB domain-containing protein 7A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04116","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), Zika virus infection was found to downregulate a specific gene, which in turn i... | |
medium_hidden_intermediate_04117 | Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to KRAS via an interaction relationship. One of these genes is reported in a study (GSE108897) on macrophages with a log2 fold change of -2.093 and an adjusted p-value of 0.0009077. Which disease is associated with... | childhood leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04117","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to KRAS via an int... | |
medium_hidden_intermediate_04118 | Zika virus downregulates a specific gene that subsequently interacts with UBE2L3. In glioma stem cells, this gene exhibits a log2 fold change of approximately -3.19 and an adjusted p-value of 0.0045. Which biological process is this gene involved in? | protein autoubiquitination | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04118","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that subsequently interacts with UBE2L3. In glioma stem cells, this gene exhibits a... | |
medium_hidden_intermediate_04119 | Zika virus upregulates a gene that is involved in the regulation of the cell cycle. Evidence for this gene in cancer stem cells reports a log2 fold change of 1.635 and an adjusted p-value of 0.01278. Which disease is associated with this gene as a biomarker? | adult glioblastoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04119","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that is involved in the regulation of the cell cycle. Evidence for this gene in cancer stem ce... | |
medium_hidden_intermediate_04121 | Two genes are upregulated by Influenza A virus and associated with renal cell carcinoma. One of these genes shows a log2 fold change of approximately 1.14 and an adjusted p-value of 0.0004855 in a specific study. Which cell type is enriched for this specific gene? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04121","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Influenza A virus and associated with renal cell carcinoma. One of these genes shows a log2 fol... | |
medium_hidden_intermediate_04122 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and enables sequence-specific DNA binding. This gene exhibits a log2 fold change of 1.065 and an adjusted p-value of 6.065e-06. Which biological process is this gene involved in? | positive regulation of transcription by RNA polymerase II | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04122","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and e... | |
medium_hidden_intermediate_04123 | Zaire ebolavirus downregulates a specific gene, which in turn participates in disease processes. Experimental data from a study on retinal pigment epithelium cells (GSE100839) indicates that this gene has a log2 fold change of -1.201 and an adjusted p-value of 0.005648. Which protein is encoded by this gene? | Adenosine receptor A2b | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04123","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus downregulates a specific gene, which in turn participates in disease processes. Experimental data from a st... | |
medium_hidden_intermediate_04125 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate multiple genes whose protein products are located in the early endosome. One such gene exhibited a log2 fold change of 1.755 and an adjusted p-value of 1.177e-05. Which protein is encoded by this specific gene? | Early endosome antigen 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04125","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate multiple genes whos... | |
medium_hidden_intermediate_04126 | Two distinct entities are structurally linked between Interferon alfa-2a, Recombinant and Vemurafenib via interaction relationships. One of these entities is described in the following evidence: 'Intriguingly, application of a statin-related drug, this entity, also resulted in a synergistic increase of sensitivity to v... | coronary atherosclerosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04126","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct entities are structurally linked between Interferon alfa-2a, Recombinant and Vemurafenib via interaction relati... | |
medium_hidden_intermediate_04128 | In a study of Influenza A virus infection, a specific gene is upregulated and participates in the RHO GTPase cycle. Evidence for this gene reports a log2 fold change of approximately 1.043 and an adjusted p-value of 0.006061. Which cellular component is this gene located in? | phagocytic cup | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04128","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is upregulated and participates in the RHO GTPase cycle. Evidence... | |
medium_hidden_intermediate_04130 | Hepacivirus C upregulates a gene that participates in the regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). Evidence for one such gene reports a log2 fold change of 1.455 and an adjusted p-value of 0.001852. Which cell type is this gene enriched... | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04130","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in the regulation of Insulin-like Growth Factor (IGF) transport and uptak... | |
medium_hidden_intermediate_04132 | In a study of cervical adenocarcinoma cells (GSE11238), a gene is upregulated by Vaccinia virus and participates in the HIV life cycle. This specific gene exhibits a log2 fold change of 1.536 and an adjusted p-value of 4.071e-10. Which protein is encoded by this gene? | Glycylpeptide N-tetradecanoyltransferase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04132","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), a gene is upregulated by Vaccinia virus and participates in the HIV ... | |
medium_hidden_intermediate_04133 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and participates in G alpha (q) signalling events. Evidence for this gene reports a log2 fold change of 4.599 and an adjusted p-value of 0.04887. Which protein is encoded by this gene? | Oxytocin receptor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04133","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and participat... | |
medium_hidden_intermediate_04134 | Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to 'negative regulation of cell growth' via an 'involved in' relationship. One of these genes is reported in study GSE108897 (macrophages) with a log2 fold change of approximately -1.78 and an adjusted p-value of ... | gastric cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04134","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to 'negative regu... | |
medium_hidden_intermediate_04135 | A gene is downregulated by Human gammaherpesvirus 8 and participates in Signaling by Rho GTPases. Experimental evidence for this gene reports a log2 fold change of -1.954 and an adjusted p-value of 0.00512. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04135","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Human gammaherpesvirus 8 and participates in Signaling by Rho GTPases. Experimental evidence for ... | |
medium_hidden_intermediate_04137 | Hepacivirus C upregulates a gene that participates in RNA metabolism. Evidence for one such gene reports a log2 fold change of 1.735 and an adjusted p-value of 0.001856. Which disease is associated with that gene? | intellectual developmental disorder, autosomal recessive 68 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04137","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in RNA metabolism. Evidence for one such gene reports a log2 fold change ... | |
medium_hidden_intermediate_04138 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in the Pentose phosphate pathway. One of these genes exhibits a log2 fold change of -2.328 and an adjusted p-value of 0.001111 in a specific study. Which protein is encoded by this gene? | Deoxyribose-phosphate aldolase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04138","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in the Pentose phosphat... | |
medium_hidden_intermediate_04139 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a gene that enables calcium ion binding. This specific gene exhibited a log2 fold change of approximately 1.36 and an adjusted p-value of 0.0379. Which protein is encoded by this gene? | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04139","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a gene that enables calciu... | |
medium_hidden_intermediate_04141 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and serve as biomarkers for hepatocellular carcinoma. One of these genes exhibits a log2 fold change of 4.042 and an adjusted p-value of 0.0006631 in lung tissue data from study GSE148697. What molecular function is enabled by this speci... | serine-type endopeptidase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04141","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and serve as biomarkers for hepatocellula... | |
medium_hidden_intermediate_04143 | A gene serves as a marker for cancer cells and is enriched in intermediate monocytes. Evidence for this gene includes a mean expression of 27.05 TPM, a z-score of 1.50, and a fold enrichment of 3.91. Which disease is associated with this gene? | glioma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04143","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for cancer cells and is enriched in intermediate monocytes. Evidence for this gene includes a mean... | |
medium_hidden_intermediate_04144 | Human betaherpesvirus 5 is known to downregulate a specific gene that is enriched in plasmacytoid dendritic cells. Experimental data for this gene in foreskin fibroblast cell lines reports a log2 fold change of approximately -1.406 and an adjusted p-value of 0.04454. Which biological process is this gene involved in? | nuclear-transcribed mRNA catabolic process, non-stop decay | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04144","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is known to downregulate a specific gene that is enriched in plasmacytoid dendritic cells. Experimen... | |
medium_hidden_intermediate_04146 | Hepacivirus C is reported to downregulate a specific gene, which in turn participates in disease processes. Experimental data for this gene indicates a log2 fold change of -2.416 and an adjusted p-value of 8.123e-05. In which cell type is this gene enriched? | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04146","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a specific gene, which in turn participates in disease processes. Experimental dat... | |
medium_hidden_intermediate_04147 | Human betaherpesvirus 5 is linked to neuralgia via a gene that it downregulates and which is associated with the condition. One such gene exhibits a log2 fold change of -3.232 and an adjusted p-value of 0.0346 in foreskin fibroblast cell lines. Which protein is encoded by this specific gene? | G-protein coupled receptor 135 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04147","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is linked to neuralgia via a gene that it downregulates and which is associated with the condition. ... | |
medium_hidden_intermediate_04148 | Human betaherpesvirus 5 is reported to downregulate a gene that is associated with non-small cell lung carcinoma. In a study of foreskin fibroblast cell lines (GSE111036), one such gene exhibits a log2 fold change of approximately -1.58 and an adjusted p-value of approximately 0.05. Which protein is encoded by this spe... | Ribosomal oxygenase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04148","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that is associated with non-small cell lung carcinoma. In a study... | |
medium_hidden_intermediate_04150 | Zaire ebolavirus downregulates a gene that participates in the Immune System. Experimental data from a study on retinal pigment epithelium cells (GSE100839) indicates that this specific gene has a log2 fold change of -1.732 and an adjusted p-value of 3.688e-05. Which disease is associated with this gene? | myeloid leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04150","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus downregulates a gene that participates in the Immune System. Experimental data from a study on retinal pigm... | |
medium_hidden_intermediate_04152 | Zika virus downregulates a specific gene that participates in the Nuclear Receptor transcription pathway. Experimental data from glioma stem cells (study GSE114907) indicates this gene has a log2 fold change of -1.625 and an adjusted p-value of 0.005393. Which disease is associated with this gene? | leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04152","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in the Nuclear Receptor transcription pathway. Experimental data ... | |
medium_hidden_intermediate_04153 | A gene is downregulated by Cardiovirus A and participates in the metabolism of RNA. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of -1.116 and an adjusted p-value of 0.01485. Which cell type is this gene enriched in? | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04153","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Cardiovirus A and participates in the metabolism of RNA. Experimental data for this gene in a cer... | |
medium_hidden_intermediate_04154 | A gene is downregulated by Primate bocaparvovirus 1 and participates in the Immune System. Experimental evidence for this gene shows a log2 fold change of -2.315 and an adjusted p-value of 0.01592. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04154","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and participates in the Immune System. Experimental evidence for this ge... | |
medium_hidden_intermediate_04157 | In a study of glioma stem cells (GSE114907), a gene is downregulated by Zika virus and interacts with TNFAIP3. This specific gene exhibits a log2 fold change of -1.207 and an adjusted p-value of 0.03033. Which protein is encoded by this gene? | Ankyrin repeat domain-containing protein 13D | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04157","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), a gene is downregulated by Zika virus and interacts with TNFAIP3. This specific... | |
medium_hidden_intermediate_04158 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene is upregulated and participates in the RAC1 GTPase cycle. Evidence for this gene reports a log2 fold change of 1.157 and an adjusted p-value of 0.03243. Which protein is encoded by this gene? | Puratrophin-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04158","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene is upregulated... | |
medium_hidden_intermediate_04159 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to NR1H2 and NR1H3-mediated signaling via a 'participates in' relationship. One of these genes is associated with experimental data showing a log2 fold change of -2.803 and an adjusted p-val... | ACSF2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04159","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_04161 | Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to leukemia via an association relationship. One of these genes exhibits a log2 fold change of -1.331 and an adjusted p-value of 0.01497 in macrophages (study GSE108897). Which protein is encoded by the gene matchi... | Metallothionein-1E | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04161","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to leukemia via an... | |
medium_hidden_intermediate_04162 | Zika virus downregulates a gene that is involved in the cellular response to oxidative stress. Transcriptomic data from glioma stem cells (study GSE114907) indicates that this specific gene has a log2 fold change of -1.167 and an adjusted p-value of 0.008687. Which protein is encoded by this gene? | Peptidyl-glycine alpha-amidating monooxygenase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04162","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the cellular response to oxidative stress. Transcriptomic data from glio... | |
medium_hidden_intermediate_04163 | EP300 interacts with a transcription factor that possesses DNA-binding activity. A study reports that the coactivator p300 directly acetylates lysines in the carboxyl-terminal region of this specific transcription factor in vivo and in vitro, thereby potently stimulating its induction of IGF-binding protein-1 transcrip... | Forkhead box protein O1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04163","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"EP300 interacts with a transcription factor that possesses DNA-binding activity. A study reports that the coactivator p300 d... | |
medium_hidden_intermediate_04164 | Two genes are linked to Hepacivirus C via upregulation and to schizophrenia via genomic alterations. One of these genes exhibits a log2 fold change of approximately 1.437 and an adjusted p-value of 0.03916 in a specific study. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04164","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Hepacivirus C via upregulation and to schizophrenia via genomic alterations. One of these genes exhi... | |
medium_hidden_intermediate_04165 | In a study of sclera cells (GSE164073), Severe acute respiratory syndrome-related coronavirus was found to upregulate a gene that enables small GTPase binding. This specific gene exhibited a log2 fold change of 1.221 and an adjusted p-value of 5.307e-05. Which protein is encoded by this gene? | CYFIP-related Rac1 interactor B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04165","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of sclera cells (GSE164073), Severe acute respiratory syndrome-related coronavirus was found to upregulate a gene... | |
medium_hidden_intermediate_04167 | In a study of hepatoma cells infected with Dengue virus (GSE110512), two genes are upregulated and known to interact with YWHAB. One of these genes exhibits a log2 fold change of approximately 1.59 and an adjusted p-value of 0.0076. Which protein is encoded by this specific gene? | Cordon-bleu protein-like 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04167","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of hepatoma cells infected with Dengue virus (GSE110512), two genes are upregulated and known to interact with YW... | |
medium_hidden_intermediate_04168 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the Toll Like Receptor 9 (TLR9) Cascade. Experimental data for this gene shows a log2 fold change of 2.934 and an adjusted p-value of 0.03056. In which cell type is this gene enriched? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04168","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the Toll Like Receptor 9 ... | |
medium_hidden_intermediate_04169 | Pegivirus C is reported to downregulate a gene that enables clathrin binding. Among the genes fitting this description, one exhibits a log2 fold change of -1.198 and an adjusted p-value of 0.002815 in peripheral blood mononuclear cells. Which cell type is this specific gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04169","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that enables clathrin binding. Among the genes fitting this description, one ... | |
medium_hidden_intermediate_04170 | Pegivirus C is reported to downregulate a specific gene, which in turn participates in Signaling by the B Cell Receptor (BCR). Experimental data for this gene in peripheral blood mononuclear cells (from study GSE131504) indicates a log2 fold change of approximately -2.71 and an adjusted p-value of approximately 0.019. ... | Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04170","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn participates in Signaling by the B Cell Receptor (BCR... | |
medium_hidden_intermediate_04171 | Measles morbillivirus is known to upregulate certain genes that are subsequently associated with breast carcinoma via genomic alterations. One such gene exhibits a log2 fold change of approximately 2.38 and an adjusted p-value of approximately 0.028 in study GSE131840. Which cell type is this specific gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04171","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus is known to upregulate certain genes that are subsequently associated with breast carcinoma via genomi... | |
medium_hidden_intermediate_04177 | Pegivirus C is reported to downregulate a specific gene that is involved in the proteasome-mediated ubiquitin-dependent protein catabolic process. In a study of peripheral blood mononuclear cells (GSE131504), this gene exhibited a log2 fold change of -1.635 and an adjusted p-value of 0.0005627. Which disease is associa... | left ventricular noncompaction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04177","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene that is involved in the proteasome-mediated ubiquitin-dependent prot... | |
medium_hidden_intermediate_04178 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is downregulated and participates in the Adaptive Immune System. Evidence for this gene reports a log2 fold change of -1.082 and an adjusted p-value of 7.327e-09. Which protein is encoded by this gene? | BTB/POZ domain-containing protein 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04178","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is downregulated and... | |
medium_hidden_intermediate_04179 | Zika virus downregulates a gene that participates in sphingolipid metabolism. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of approximately -1.89 and an adjusted p-value of 0.0155. Which protein is encoded by this specific gene? | ORM1-like protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04179","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in sphingolipid metabolism. In a study of glioma stem cells (GSE114907), o... | |
medium_hidden_intermediate_04180 | Zika virus is reported to downregulate a specific gene, which is in turn associated with small cell lung carcinoma. Experimental data for this gene in glioma stem cells (study GSE114907) indicate a log2 fold change of approximately -5.74 and an adjusted p-value of 0.0389. Which protein is encoded by this gene? | ATP-binding cassette sub-family C member 10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04180","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus is reported to downregulate a specific gene, which is in turn associated with small cell lung carcinoma. Experime... | |
medium_hidden_intermediate_04181 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a specific histone variant that participates in CHD chromatin remodeler activity. This entity exhibits a log2 fold change of approximately 3.10 and an adjusted p-value of 0.00275. Which protein is encoded by this upregulated entity? | Histone H3.1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04181","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a specific histone variant that part... | |
medium_hidden_intermediate_04182 | In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and its protein product interacts with TOP3B. Experimental data for this gene shows a log2 fold change of approximately 1.33 and an adjusted p-value of approximately 0.000376. Which protein is encoded by this gene? | Bystin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04182","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and its protein product interacts... |
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