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medium_hidden_intermediate_04322 | A gene is upregulated by Human gammaherpesvirus 8 and participates in the Adaptive Immune System. Experimental data for this gene in a non-Hodgkin lymphoma cell line (study GSE119608) reports a log2 fold change of 1.059 and an adjusted p-value of 0.02929. Which disease is associated with this gene? | invasive breast carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04322","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human gammaherpesvirus 8 and participates in the Adaptive Immune System. Experimental data for this... | |
medium_hidden_intermediate_04323 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in calcium ion transmembrane transport. Evidence for one such gene reports a log2 fold change of 1.593 and an adjusted p-value of 0.01321. Which protein is encoded by that gene? | Transient receptor potential cation channel subfamily M member 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04323","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in calcium ion transmembrane trans... | |
medium_hidden_intermediate_04324 | Cardiovirus A is reported to downregulate a gene that is involved in the positive regulation of transcription by RNA polymerase II. Experimental data from a cervical adenocarcinoma cell line (study GSE122967) indicates that this specific gene has a log2 fold change of -1.003 and an adjusted p-value of 0.03397. Which pr... | Zinc finger protein 300 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04324","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A is reported to downregulate a gene that is involved in the positive regulation of transcription by RNA polymer... | |
medium_hidden_intermediate_04326 | Zika virus downregulates a gene that interacts with FXR1. In a study of glioma stem cells (GSE114907), one such gene exhibits a log2 fold change of -1.424 and an adjusted p-value of 0.04663. Which protein is encoded by this gene? | Pleckstrin homology-like domain family B member 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04326","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with FXR1. In a study of glioma stem cells (GSE114907), one such gene exhibit... | |
medium_hidden_intermediate_04327 | Zika virus infection leads to the downregulation of certain genes that participate in RNA Polymerase I transcription. In a study of glioma stem cells (GSE114907), one such downregulated gene exhibited a log2 fold change of approximately -1.48 and an adjusted p-value of 0.0156. Which protein is encoded by this specific ... | Methyl-CpG-binding domain protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04327","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection leads to the downregulation of certain genes that participate in RNA Polymerase I transcription. In a s... | |
medium_hidden_intermediate_04329 | FUS interacts with a specific protein that enables protein binding. Evidence regarding this protein states: 'We studied the interaction between this protein and FUS and its contribution to glioma progression.' Which disease is associated with this protein through genomic alterations? | follicular lymphoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04329","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"FUS interacts with a specific protein that enables protein binding. Evidence regarding this protein states: 'We studied the ... | |
medium_hidden_intermediate_04330 | In a study of Measles morbillivirus infection, multiple genes are downregulated and their products are located in the endoplasmic reticulum. One such gene exhibits a log2 fold change of -1.699 and an adjusted p-value of 0.002831. Which protein is encoded by this specific gene? | Novel acetylcholine receptor chaperone | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04330","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, multiple genes are downregulated and their products are located in the endopl... | |
medium_hidden_intermediate_04333 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and to translation initiation factor activity via an 'enables' relationship. One of these genes is associated with experimental data showing a log2 fold change of approximately 1.158 and an adjus... | CCNF | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04333","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship... | |
medium_hidden_intermediate_04334 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in DDX58/IFIH1-mediated induction of interferon-alpha/beta. Evidence for one such gene reports a log2 fold change of 1.118 and an adjusted p-value of 0.0001422. Which protein is encoded by that gene? | NF-kappa-B inhibitor beta | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04334","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in DDX58/IFIH1-mediated induction... | |
medium_hidden_intermediate_04335 | A gene is upregulated by Human immunodeficiency virus 1 and participates in Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation. Experimental data for this gene in natural killer cells from study GSE125686 reports a log2 fold change of approximately 3.37 and an adjusted p-value of approxima... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04335","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human immunodeficiency virus 1 and participates in Gamma carboxylation, hypusinylation, hydroxylati... | |
medium_hidden_intermediate_04338 | Human alphaherpesvirus 1 upregulates a gene that is enriched in basophils. Evidence for this gene reports a log2 fold change of 1.918 and an adjusted p-value of 0.0197. Which protein is encoded by this gene? | CASP8-associated protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04338","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that is enriched in basophils. Evidence for this gene reports a log2 fold change... | |
medium_hidden_intermediate_04339 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to SMC1A via a 'binds' relationship. One of these genes has an associated expression profile showing a log2 fold change of -1.064 and an adjusted p-value of 0.002733. Which disease is associ... | malaria | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04339","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_04340 | Two genes are downregulated by Cardiovirus A and are associated with glioma. One of these genes exhibits a log2 fold change of -1.009 and an adjusted p-value of 0.01317 in cervical adenocarcinoma cell lines (study GSE122967). Which biological process is this specific gene involved in? | ATP generation from poly-ADP-D-ribose | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04340","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Cardiovirus A and are associated with glioma. One of these genes exhibits a log2 fold change ... | |
medium_hidden_intermediate_04341 | Vaccinia virus downregulates a gene that participates in Signaling by Rho GTPases. In a study of cervical adenocarcinoma cell lines (GSE11238), one such gene exhibited a log2 fold change of approximately -3.71 and an adjusted p-value of 0.0438. Which protein is encoded by this specific gene? | WASP homolog-associated protein with actin, membranes and microtubules | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04341","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus downregulates a gene that participates in Signaling by Rho GTPases. In a study of cervical adenocarcinoma cel... | |
medium_hidden_intermediate_04343 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific gene, which is involved in the positive regulation of transcription by RNA polymerase II. This gene exhibited a log2 fold change of approximately -1.34 and an adjusted p-value of approximately 0.01... | Transcription factor E3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04343","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific g... | |
medium_hidden_intermediate_04345 | Conjugated estrogens interact with a specific drug, which in turn interacts with Estrone sulfate. Evidence regarding this drug states: 'Regardless of cell lines, T slightly decreased STS activity after direct incubation, but led to an increase of local estrogen formation after 24h which was attenuated, and partly rever... | breast cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04345","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Conjugated estrogens interact with a specific drug, which in turn interacts with Estrone sulfate. Evidence regarding this dr... | |
medium_hidden_intermediate_04347 | In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and enables protein kinase activity. This specific gene exhibits a log2 fold change of approximately -1.125 and an adjusted p-value of 0.02388. Which protein is encoded by this gene? | Serine/threonine-protein kinase haspin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04347","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and enab... | |
medium_hidden_intermediate_04349 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Leishmania infection. Experimental data for this gene reports a log2 fold change of 1.083 and an adjusted p-value of 0.0002163. Which disease is associated with this gene? | abscess | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04349","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Leishmania infection. Exp... | |
medium_hidden_intermediate_04350 | Measles morbillivirus upregulates a gene that interacts with RAB11A. Evidence for one such gene reports a log2 fold change of 1.391 and an adjusted p-value of 0.01415. Which disease is associated with that gene? | lymphoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04350","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that interacts with RAB11A. Evidence for one such gene reports a log2 fold change o... | |
medium_hidden_intermediate_04352 | Two genes are structurally linked to Human immunodeficiency virus 1 via an upregulation relationship and to the biological process 'Regulation of lipid metabolism by PPARalpha' via a participation relationship. One of these genes is associated with experimental evidence showing a log2 fold change of approximately 1.501... | long-chain fatty acid-CoA ligase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04352","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via an upregulation relationship and to the biological p... | |
medium_hidden_intermediate_04353 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and to ITCH via an 'interacts with' relationship. One of these genes is associated with a log2 fold change of 1.179 and an adjusted p-value of 0.008349 in a specific study. Which cell type is thi... | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04353","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship... | |
medium_hidden_intermediate_04354 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to the biological process 'Regulation of Homotypic Cell-Cell Adhesion' via a 'participates in' relationship. One of these genes is reported in a study (GSE151803) using a pancreatic cell lin... | severe combined immunodeficiency | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04354","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_04355 | In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and participates in Phase II - Conjugation of compounds. This specific gene exhibits a log2 fold change of -1.580 and an adjusted p-value of 0.001147. Which cellular component is this gene located in? | cytosol | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04355","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and part... | |
medium_hidden_intermediate_04356 | Human alphaherpesvirus 1 is reported to upregulate a gene that is associated with gastric cancer. In a study of monocytic leukemia cell lines (GSE114966), one such gene exhibits a log2 fold change of 1.481 and an adjusted p-value of 0.00244. Which protein is encoded by this specific gene? | Protein lin-9 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04356","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 is reported to upregulate a gene that is associated with gastric cancer. In a study of monocytic le... | |
medium_hidden_intermediate_04357 | Human betaherpesvirus 5 upregulates a gene that participates in the metabolism of lipids. Evidence for this gene in retinal pigment epithelium cells (study GSE120891) reports a log2 fold change of 2.072 and an adjusted p-value of 0.01028. Which protein is encoded by this gene? | L-fucose dehydrogenase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04357","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that participates in the metabolism of lipids. Evidence for this gene in retinal ... | |
medium_hidden_intermediate_04358 | In a study of macrophages (GSE108897), a gene is identified as being downregulated by Human immunodeficiency virus 1 and serving as a biomarker for stroke disorder. This specific gene exhibits a log2 fold change of -2.207 and an adjusted p-value of 0.0002978. Which protein is encoded by this gene? | Mesencephalic astrocyte-derived neurotrophic factor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04358","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified as being downregulated by Human immunodeficiency virus 1 and ser... | |
medium_hidden_intermediate_04363 | Hepacivirus C is reported to downregulate a gene that participates in sulfur amino acid metabolism. In a study of peripheral blood mononuclear cells (GSE119117), one such gene showed a log2 fold change of approximately -1.49 and an adjusted p-value of 0.034. Which protein is encoded by this specific gene? | Thiosulfate sulfurtransferase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04363","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that participates in sulfur amino acid metabolism. In a study of peripheral... | |
medium_hidden_intermediate_04364 | Two genes are downregulated by Measles morbillivirus and located in extracellular exosomes. One of these genes exhibits a log2 fold change of -1.187 and an adjusted p-value of 0.006783 in pleural mesothelioma cells. Which cell type is enriched for this specific gene? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04364","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Measles morbillivirus and located in extracellular exosomes. One of these genes exhibits a lo... | |
medium_hidden_intermediate_04367 | Two genes are upregulated by Vaccinia virus and participate in Cytokine Signaling in the Immune system. One of these genes exhibits a log2 fold change of 3.663 and an adjusted p-value of 1.08e-09 in cervical adenocarcinoma cell lines. Which disease is associated with this specific gene as a biomarker? | schizophrenia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04367","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and participate in Cytokine Signaling in the Immune system. One of these genes e... | |
medium_hidden_intermediate_04370 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with UBE2I. Experimental data for this gene in a colonic adenocarcinoma cell line (study GSE148729) reports a log2 fold change of approximately 2.178 and an adjusted p-value of 0.04737. Which protein is encoded by this gene? | Borealin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04370","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with UBE2I. Experimental data for th... | |
medium_hidden_intermediate_04372 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the mitochondrial intermembrane space. Evidence for one such gene reports a log2 fold change of approximately 1.237 and an adjusted p-value of 0.04325. Which protein does this specific gene product bind to? | GFER | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04372","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the mitochondrial intermembrane ... | |
medium_hidden_intermediate_04373 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with sarcoma. One of these genes exhibits a log2 fold change of -2.671 and an adjusted p-value of 0.01584 in a specific study. Which protein is encoded by this gene? | Suppressor of tumorigenicity 14 protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04373","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with sarcoma. One of... | |
medium_hidden_intermediate_04374 | Human immunodeficiency virus 1 upregulates a gene that is involved in the negative regulation of transcription by RNA polymerase II. Evidence for this gene in macrophages (study GSE108897) reports a log2 fold change of 1.549 and an adjusted p-value of 0.0001117. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04374","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is involved in the negative regulation of transcription by RNA polyme... | |
medium_hidden_intermediate_04375 | In a study of Hepacivirus C infection in hepatocytes (GSE132606), two genes are upregulated by the virus and both bind to TSEN34. One of these genes exhibits a log2 fold change of approximately 1.23 and an adjusted p-value of 3.98e-07. Which protein is encoded by this specific gene? | tRNA-splicing endonuclease subunit Sen2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04375","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Hepacivirus C infection in hepatocytes (GSE132606), two genes are upregulated by the virus and both bind to TS... | |
medium_hidden_intermediate_04376 | A gene is downregulated by Human gammaherpesvirus 8 and is enriched in natural killer cells. Evidence for this gene reports a log2 fold change of approximately -1.224 and an adjusted p-value of 0.03615. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04376","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Human gammaherpesvirus 8 and is enriched in natural killer cells. Evidence for this gene reports ... | |
medium_hidden_intermediate_04377 | Human alphaherpesvirus 3 upregulates multiple genes that are involved in the cellular response to lipopolysaccharide. One such gene exhibits a log2 fold change of 1.749 and an adjusted p-value of 4.927e-06 in a melanoma cell line study (GSE136586). Which protein is encoded by this specific gene? | Interleukin-18 receptor accessory protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04377","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 upregulates multiple genes that are involved in the cellular response to lipopolysaccharide. One su... | |
medium_hidden_intermediate_04381 | In a study of sclera cells (GSE164073), Severe acute respiratory syndrome-related coronavirus was found to upregulate a specific gene, which in turn interacts with KIAA0020. The expression data for this intermediate gene shows a log2 fold change of approximately 1.22 and an adjusted p-value of 0.0018. Which protein is ... | Probable rRNA-processing protein EBP2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04381","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of sclera cells (GSE164073), Severe acute respiratory syndrome-related coronavirus was found to upregulate a spec... | |
medium_hidden_intermediate_04383 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is associated with multiple sclerosis. Evidence for this gene reports a log2 fold change of -1.289 and an adjusted p-value of 0.01802. Which protein is encoded by this gene? | Immunoglobulin-binding protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04383","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is associated with multiple sclerosis. ... | |
medium_hidden_intermediate_04384 | Pegivirus C is reported to downregulate a gene that enables transcription corepressor activity. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.194 and an adjusted p-value of 0.003. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04384","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that enables transcription corepressor activity. In a study of peripheral blo... | |
medium_hidden_intermediate_04385 | Two genes are each downregulated by Severe acute respiratory syndrome-related coronavirus and associated with bipolar disorder. One of these genes exhibits a log2 fold change of -2.323 and an adjusted p-value of 0.0433 in a specific study. Which gene interacts with the gene exhibiting these specific expression statisti... | RPS3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04385","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each downregulated by Severe acute respiratory syndrome-related coronavirus and associated with bipolar disord... | |
medium_hidden_intermediate_04386 | Vaccinia virus downregulates a gene that participates in the Immune System. In a study of cervical adenocarcinoma cell lines (GSE11238), one such gene exhibited a log2 fold change of -2.047 and an adjusted p-value of 0.001106. Which protein is encoded by this specific gene? | Sialic acid-binding Ig-like lectin 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04386","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus downregulates a gene that participates in the Immune System. In a study of cervical adenocarcinoma cell lines... | |
medium_hidden_intermediate_04387 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables calcium-dependent phospholipid binding. Transcriptomic data for this gene shows a log2 fold change of 4.095 and an adjusted p-value of 0.004825. Which protein is encoded by this gene? | Synaptotagmin-7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04387","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables calcium-dependent phospholipid binding... | |
medium_hidden_intermediate_04388 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in SLC-mediated transmembrane transport. Evidence for one such gene reports a log2 fold change of -1.050 and an adjusted p-value of 0.00876. Which protein is encoded by that gene? | Proton myo-inositol cotransporter | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04388","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in SLC-mediated transmembrane t... | |
medium_hidden_intermediate_04389 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and subsequently interacts with VCP. Evidence for this gene reports a log2 fold change of 1.554 and an adjusted p-value of 0.04338. Which protein is encoded by this gene? | Equilibrative nucleobase transporter 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04389","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and subsequent... | |
medium_hidden_intermediate_04390 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene that is involved in the regulation of inflammatory response. This gene exhibited a log2 fold change of -1.580 and an adjusted p-value of 0.0003587. Which protein is encoded by this gene? | A disintegrin and metalloproteinase with thrombospondin motifs 12 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04390","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene that is invo... | |
medium_hidden_intermediate_04392 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and binds to MT-CO1. Evidence for this gene reports a log2 fold change of 2.140 and an adjusted p-value of 0.014. Which disease is associated with this gene? | intervertebral disk degenerative disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04392","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and binds to MT-CO1. Evidence for this gene r... | |
medium_hidden_intermediate_04395 | Human immunodeficiency virus 1 upregulates a gene that participates in MAPK family signaling cascades. Evidence for this gene in natural killer cells (study GSE125686) reports a log2 fold change of 4.409 and an adjusted p-value of 0.03919. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04395","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in MAPK family signaling cascades. Evidence for this gen... | |
medium_hidden_intermediate_04397 | Zika virus upregulates a gene that enables histone binding. In a study of neural stem cells (GSE129180), one such gene showed a log2 fold change of approximately 1.34 and an adjusted p-value of 0.00343. Which protein is encoded by this gene? | Zinc finger ZZ-type and EF-hand domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04397","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that enables histone binding. In a study of neural stem cells (GSE129180), one such gene showe... | |
medium_hidden_intermediate_04399 | Influenza A virus upregulates a specific gene that is enriched in Regulatory T (Treg) cells. Experimental data for this gene reports a log2 fold change of 1.124 and an adjusted p-value of 4.471e-05. Which cellular component is this gene located in? | focal adhesion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04399","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Influenza A virus upregulates a specific gene that is enriched in Regulatory T (Treg) cells. Experimental data for this gene... | |
medium_hidden_intermediate_04401 | A gene is downregulated by Cardiovirus A and enables DNA binding. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of approximately -1.06 and an adjusted p-value of approximately 0.0122. Which cell type is this gene enriched in? | naive B cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04401","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Cardiovirus A and enables DNA binding. Experimental data for this gene in a cervical adenocarcino... | |
medium_hidden_intermediate_04403 | Two genes are structurally linked to Measles morbillivirus via an 'upregulates' relationship and to Regulatory T (Treg) cells via an 'enriched in' relationship. One of these genes is associated with a log2 fold change of 1.390 and an adjusted p-value of 0.001173. Which protein is encoded by this specific gene? | Phospholipid-transporting ATPase ID | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04403","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Measles morbillivirus via an 'upregulates' relationship and to Regulatory T (Treg) cell... | |
medium_hidden_intermediate_04404 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that is located in the mitochondrial crista. This specific gene exhibits a log2 fold change of approximately 4.03 and an adjusted p-value of 0.003785. Which protein is encoded by this gene? | Cytochrome c oxidase subunit 6B2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04404","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that is located in the mitochondria... | |
medium_hidden_intermediate_04405 | A gene is downregulated by Primate bocaparvovirus 1 and participates in the metabolism of carbohydrates and carbohydrate derivatives. Evidence for this gene reports a log2 fold change of -2.191 and an adjusted p-value of 0.003452. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04405","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and participates in the metabolism of carbohydrates and carbohydrate der... | |
medium_hidden_intermediate_04406 | A gene is downregulated by Primate bocaparvovirus 1 and is located in the mitochondrion. Experimental evidence for this gene reports a log2 fold change of -2.207 and an adjusted p-value of 0.007959. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04406","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and is located in the mitochondrion. Experimental evidence for this gene... | |
medium_hidden_intermediate_04407 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and interacts with DYNLL1. Experimental data for this gene in lung cells (study GSE148697) shows a log2 fold change of -1.933 and an adjusted p-value of 0.0171. Which disease is associated with this gene? | lymphoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04407","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and interacts with DYNLL1. Experimental dat... | |
medium_hidden_intermediate_04408 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Chromatin organization. Experimental data for this gene reports a log2 fold change of -1.461 and an adjusted p-value of 0.02248. Which cell type is this gene enriched in? | non-classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04408","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Chromatin organization.... | |
medium_hidden_intermediate_04409 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Fatty acid metabolism. Experimental data for this gene reports a log2 fold change of -1.950 and an adjusted p-value of 1.516e-05. Which cell type is this gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04409","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Fatty acid metabolism. ... | |
medium_hidden_intermediate_04410 | Pegivirus C is reported to downregulate a specific gene, which in turn participates in disease processes. Transcriptomic data from peripheral blood mononuclear cells (study GSE131504) indicates that this gene has a log2 fold change of approximately -1.49 and an adjusted p-value of 0.0012. Which cellular component is th... | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04410","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn participates in disease processes. Transcriptomic dat... | |
medium_hidden_intermediate_04412 | Two genes are upregulated by Human immunodeficiency virus 1 and associated with diabetes mellitus. One of these genes exhibits a log2 fold change of 1.226 and an adjusted p-value of 7.861e-06 in macrophages (study GSE108897). Which biological process is this specific gene involved in? | phosphate-containing compound metabolic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04412","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and associated with diabetes mellitus. One of these genes exhibi... | |
medium_hidden_intermediate_04415 | Pegivirus C is reported to downregulate a specific gene, which in turn interacts with HIST1H2BG. Experimental data for this intermediate gene in peripheral blood mononuclear cells (from study GSE131504) shows a log2 fold change of approximately -1.56 and an adjusted p-value of approximately 0.0076. Which biological pro... | dosage compensation by inactivation of X chromosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04415","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn interacts with HIST1H2BG. Experimental data for this ... | |
medium_hidden_intermediate_04416 | Two genes are structurally linked to Measles morbillivirus via an upregulation relationship and to non-classical monocytes via an enrichment relationship. One of these genes is associated with a study reporting a log2 fold change of approximately 2.005 and an adjusted p-value of 0.0005084. Which protein does this speci... | STAU1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04416","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Measles morbillivirus via an upregulation relationship and to non-classical monocytes v... | |
medium_hidden_intermediate_04417 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with gastric cancer. One of these genes exhibits a log2 fold change of 1.168 and an adjusted p-value of 0.004893 in a specific study. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04417","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with gastric cancer. O... | |
medium_hidden_intermediate_04420 | In a study of the sclera (GSE164073), Severe acute respiratory syndrome-related coronavirus was found to downregulate a specific gene that functions as an extracellular matrix structural constituent. This gene exhibited a log2 fold change of -1.853 and an adjusted p-value of 0.001951. Which biological process is this g... | extracellular matrix organization | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04420","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of the sclera (GSE164073), Severe acute respiratory syndrome-related coronavirus was found to downregulate a spec... | |
medium_hidden_intermediate_04421 | Human immunodeficiency virus 1 upregulates a gene that participates in the transport of small molecules. Evidence for one such gene reports a log2 fold change of 1.340 and an adjusted p-value of 0.01722. Which disease is associated with that gene as a biomarker? | alcohol abuse | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04421","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in the transport of small molecules. Evidence for one su... | |
medium_hidden_intermediate_04422 | Two genes are upregulated by Human immunodeficiency virus 1 and are involved in the positive regulation of protein catabolic process. One of these genes exhibits a log2 fold change of 3.348 and an adjusted p-value of 0.003389 in a specific study. Which cell type is enriched for this specific gene? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04422","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and are involved in the positive regulation of protein catabolic... | |
medium_hidden_intermediate_04423 | Two genes are upregulated by Human immunodeficiency virus 1 and participate in Phase 4 - resting membrane potential. One of these genes exhibits a log2 fold change of approximately 1.12 and an adjusted p-value of 0.007024 in natural killer cells. Which molecular function is enabled by this specific gene? | inward rectifier potassium channel activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04423","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and participate in Phase 4 - resting membrane potential. One of ... | |
medium_hidden_intermediate_04425 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in MAPK family signaling cascades. Experimental data for this gene reports a log2 fold change of 1.382 and an adjusted p-value of 0.007167. Which disease is associated with this gene? | carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04425","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in MAPK family signaling cas... | |
medium_hidden_intermediate_04426 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene is upregulated and participates in Phase II - Conjugation of compounds. This gene exhibits a log2 fold change of 2.258 and an adjusted p-value of 0.001641. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04426","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene is upregulated... | |
medium_hidden_intermediate_04427 | In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and participates in RNA Polymerase II Transcription. This specific gene exhibits a log2 fold change of -1.192 and an adjusted p-value of 0.003323. Which protein is encoded by this gene? | Anaphase-promoting complex subunit CDC26 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04427","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and part... | |
medium_hidden_intermediate_04428 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and involved in intraflagellar transport was found to have a log2 fold change of approximately 2.217 and an adjusted p-value of 3.569e-10. Which disease is associated with this specific gene? | short-rib thoracic dysplasia 15 with polydactyly | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04428","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and involved in intraflage... | |
medium_hidden_intermediate_04430 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with SMAD3. Experimental data for this gene shows a log2 fold change of 1.432 and an adjusted p-value of 0.005194. In which cell type is this gene enriched? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04430","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with SMAD3. Experimental data f... | |
medium_hidden_intermediate_04431 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables protein kinase binding. Transcriptomic data for this gene shows a log2 fold change of approximately 1.022 and an adjusted p-value of 0.01427. Which protein does this gene interact with? | MRM1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04431","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables protein kinase binding. Transcrip... | |
medium_hidden_intermediate_04433 | Two genes are upregulated by Human alphaherpesvirus 1 and interact with SMARCA4. One of these genes exhibits a log2 fold change of approximately 2.85 and an adjusted p-value of 0.006251 in a monocytic leukemia cell line study. Which disease is associated with genomic alterations in this specific gene? | Meier-Gorlin syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04433","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human alphaherpesvirus 1 and interact with SMARCA4. One of these genes exhibits a log2 fold cha... | |
medium_hidden_intermediate_04434 | In a study of cardiomyocyte cell lines (GSE151879), a gene is upregulated by Severe acute respiratory syndrome-related coronavirus. This gene's product interacts with CCDC6. The gene exhibits a log2 fold change of 1.129 and an adjusted p-value of 0.006992. Which protein is encoded by this gene? | Serine/threonine-protein phosphatase 4 regulatory subunit 3A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04434","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cardiomyocyte cell lines (GSE151879), a gene is upregulated by Severe acute respiratory syndrome-related coron... | |
medium_hidden_intermediate_04435 | Human immunodeficiency virus 1 downregulates multiple genes that are involved in leukocyte tethering or rolling. One such gene exhibits a log2 fold change of -2.571 and an adjusted p-value of 0.001343 in macrophages. Which protein is encoded by this specific gene? | Podocalyxin-like protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04435","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates multiple genes that are involved in leukocyte tethering or rolling. One such ge... | |
medium_hidden_intermediate_04436 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and to AMPylase activity via an 'enables' relationship. One of these genes was reported in a study (GSE151879) using a cardiomyocyte cell line, with a log2 fold change of approximately 1.003 and ... | Protein adenylyltransferase FICD | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04436","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship... | |
medium_hidden_intermediate_04437 | Zaire ebolavirus infection leads to the upregulation of specific genes whose protein products are localized to the early endosome. In a study of retinal pigment epithelium cells (GSE100839), one such gene exhibited a log2 fold change of approximately 2.45 and an adjusted p-value of 0.0236. Which protein is encoded by t... | Sorting nexin-7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04437","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus infection leads to the upregulation of specific genes whose protein products are localized to the early end... | |
medium_hidden_intermediate_04438 | Human betaherpesvirus 5 is reported to downregulate a specific gene, the product of which interacts with CDC42. In a study using foreskin fibroblast cell lines, this gene exhibited a log2 fold change of -1.984 and an adjusted p-value of 0.04705. Which protein is encoded by this gene? | Guanine nucleotide exchange factor DBS | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04438","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a specific gene, the product of which interacts with CDC42. In a study u... | |
medium_hidden_intermediate_04439 | Measles morbillivirus upregulates a gene that interacts with CCNF. One such gene exhibits a log2 fold change of approximately 1.296 and an adjusted p-value of 0.01556. Which protein is encoded by this gene? | Ankyrin repeat and KH domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04439","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that interacts with CCNF. One such gene exhibits a log2 fold change of approximatel... | |
medium_hidden_intermediate_04441 | In a study of Primate bocaparvovirus 1 infection, a specific gene is downregulated by the virus and its protein product interacts with PSMD4. Experimental data for this gene shows a log2 fold change of -4.077 and an adjusted p-value of 0.04884. Which protein is encoded by this gene? | Interferon-induced transmembrane protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04441","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Primate bocaparvovirus 1 infection, a specific gene is downregulated by the virus and its protein product inte... | |
medium_hidden_intermediate_04443 | Zika virus downregulates multiple genes that are involved in mitotic metaphase chromosome alignment. One such gene exhibits a log2 fold change of -2.613 and an adjusted p-value of 0.006038 in glioma stem cells. Which cellular component is this specific gene located in? | anaphase-promoting complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04443","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates multiple genes that are involved in mitotic metaphase chromosome alignment. One such gene exhibits ... | |
medium_hidden_intermediate_04445 | A gene is downregulated by Zika virus and serves as a biomarker for gastric cancer. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.17 and an adjusted p-value of approximately 0.031. Which disease is associated with this gene through genomic alterati... | secondary neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04445","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Zika virus and serves as a biomarker for gastric cancer. Experimental data for this gene in gliom... | |
medium_hidden_intermediate_04446 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to NUP155 via an interaction relationship. One of these genes is associated with experimental data showing a log2 fold change of approximately 2.05 and an adjusted p-value of approximately 0.0... | Zinc transporter 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04446","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship ... | |
medium_hidden_intermediate_04447 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Zygotic genome activation (ZGA). One of these genes was reported in a study of bronchial epithelial cells with a log2 fold change of approximately 1.35 and an adjusted p-value of approximately 0.038. Which cellular com... | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04447","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Zygotic genome activat... | |
medium_hidden_intermediate_04448 | Uterine cervical neoplasms can be localized to anatomical structures that are subdivisions of the oviduct. One such structure is described as the initial section of the oviduct through which ova pass from the ovary to the uterus. Which anatomical entity does this specific structure develop from? | Mullerian duct | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04448","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Uterine cervical neoplasms can be localized to anatomical structures that are subdivisions of the oviduct. One such structur... | |
medium_hidden_intermediate_04449 | Hepacivirus C upregulates a gene that is involved in the positive regulation of transcription by RNA polymerase II. Experimental data from a study on hepatocytes (GSE132606) indicates that this specific gene has a log2 fold change of 1.182 and an adjusted p-value of 0.03987. Which protein is encoded by this gene? | Microtubule organization protein AKNA | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04449","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in the positive regulation of transcription by RNA polymerase II. Experime... | |
medium_hidden_intermediate_04451 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to downregulate a specific gene that participates in gastrulation. This gene exhibited a log2 fold change of approximately -1.15 and an adjusted p-value of 0.00326. Which protein is encoded by this gene? | Noggin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04451","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to downregulate a specific gene that par... | |
medium_hidden_intermediate_04452 | Hepacivirus C is reported to downregulate a specific gene, which is subsequently involved in the positive regulation of transcription by RNA polymerase II. Experimental evidence for this gene shows a log2 fold change of -1.195 and an adjusted p-value of 0.01004. Which protein is encoded by this gene? | Calcium/calmodulin-dependent protein kinase type 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04452","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a specific gene, which is subsequently involved in the positive regulation of tran... | |
medium_hidden_intermediate_04453 | Two genes are structurally linked in a pathway starting from Human immunodeficiency virus 1 (via downregulation) and ending at glioma (via association). One of these genes exhibits a log2 fold change of -1.247 and an adjusted p-value of 0.007125 in macrophages (study GSE108897). Which protein is encoded by the gene mat... | Matrix metalloproteinase-19 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04453","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked in a pathway starting from Human immunodeficiency virus 1 (via downregulation) and ending ... | |
medium_hidden_intermediate_04454 | Zika virus downregulates a gene that participates in chromatin modifying enzymes. Evidence for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -2.938 and an adjusted p-value of 0.005356. Which disease is associated with this gene? | heparin-induced thrombocytopenia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04454","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in chromatin modifying enzymes. Evidence for this gene in glioma stem cell... | |
medium_hidden_intermediate_04456 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and to VCP via an 'interacts with' relationship. One of these genes is associated with a log2 fold change of 3.530 and an adjusted p-value of 0.03142 in a specific study. Which disease is connect... | beta-thalassemia major | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04456","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship... | |
medium_hidden_intermediate_04457 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to pediatric osteosarcoma as biomarkers. One of these genes exhibits a log2 fold change of 2.046 and an adjusted p-value of 0.04403 in bronchial epithelial cells. Which cellular component is associated with this specific ... | endoplasmic reticulum membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04457","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to pediatric osteosarcoma... | |
medium_hidden_intermediate_04458 | In a study of macrophages (GSE108897), a gene is identified as being upregulated by Human immunodeficiency virus 1 and serving as a biomarker for osteoporosis. This specific gene exhibits a log2 fold change of 3.539 and an adjusted p-value of 0.003491. Which protein is encoded by this gene? | Heat shock protein beta-3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04458","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified as being upregulated by Human immunodeficiency virus 1 and servi... | |
medium_hidden_intermediate_04459 | Zaire ebolavirus downregulates a gene that participates in post-translational protein modification. In a study of retinal pigment epithelium cells (GSE100839), one such gene showed a log2 fold change of approximately -1.046 and an adjusted p-value of 0.01055. Which protein is encoded by this gene? | BTB/POZ domain-containing protein KCTD6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04459","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus downregulates a gene that participates in post-translational protein modification. In a study of retinal pi... | |
medium_hidden_intermediate_04460 | Zika virus downregulates a specific gene, which in turn interacts with HIF1A. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -2.920 and an adjusted p-value of 0.0059. Which protein is encoded by this gene? | F-box only protein 8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04460","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with HIF1A. Experimental data for this gene in glioma stem... | |
medium_hidden_intermediate_04462 | Hepacivirus C upregulates multiple genes that are involved in cell adhesion. One such gene exhibits a log2 fold change of approximately 1.216 and an adjusted p-value of 6.094e-08. Which cellular component is this specific gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04462","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates multiple genes that are involved in cell adhesion. One such gene exhibits a log2 fold change of ap... | |
medium_hidden_intermediate_04463 | Severe acute respiratory syndrome-related coronavirus downregulates a gene involved in the isoprenoid biosynthetic process. Evidence for one such gene reports a log2 fold change of -1.078 and an adjusted p-value of 0.008688. Which cell type is that gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04463","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene involved in the isoprenoid biosynthetic process. ... | |
medium_hidden_intermediate_04464 | Dengue virus infection leads to the downregulation of certain genes whose products are located in the cytoplasm. In a study of hepatoma cells (GSE110512), one such gene exhibited a log2 fold change of approximately -1.95 and an adjusted p-value of 0.0346. Which protein is encoded by this specific gene? | Centriolar and ciliogenesis-associated protein HYLS1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04464","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Dengue virus infection leads to the downregulation of certain genes whose products are located in the cytoplasm. In a study ... | |
medium_hidden_intermediate_04466 | Human betaherpesvirus 5 downregulates a gene that enables integrin binding. In a study of foreskin fibroblast cell lines (GSE111036), one such gene exhibits a log2 fold change of approximately -1.79 and an adjusted p-value of 0.0444. Which protein is encoded by this gene? | Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04466","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 downregulates a gene that enables integrin binding. In a study of foreskin fibroblast cell lines (GS... | |
medium_hidden_intermediate_04467 | Zaire ebolavirus upregulates a gene that participates in Metabolism. Evidence for this gene in retinal pigment epithelium cells (study GSE100839) reports a log2 fold change of approximately 1.052 and an adjusted p-value of 0.0001368. Which disease is associated with this gene as a biomarker? | pulmonary hypertension | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04467","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus upregulates a gene that participates in Metabolism. Evidence for this gene in retinal pigment epithelium ce... |
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