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medium_hidden_intermediate_04468 | Human immunodeficiency virus 1 downregulates a gene that is located in the spindle. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of approximately -1.528 and an adjusted p-value of approximately 0.0477. Which protein is encoded by this gene? | F-box only protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04468","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is located in the spindle. Evidence for this gene in macrophages (f... | |
medium_hidden_intermediate_04469 | In a study of macrophages (GSE108897), a gene is identified as being downregulated by Human immunodeficiency virus 1 and serving as a biomarker for depressive disorder. This specific gene exhibits a log2 fold change of approximately -2.42 and an adjusted p-value of 0.0054. Which protein is encoded by this gene? | Ornithine decarboxylase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04469","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified as being downregulated by Human immunodeficiency virus 1 and ser... | |
medium_hidden_intermediate_04471 | Two retinal structures are connected to the inner plexiform layer of the retina via an 'adjacent to' relationship and are both components of the retinal neural layer. One of these structures is described as a cytoarchitectural layer composed of a dense reticulum of fibrils formed by the interlaced dendrites of retinal ... | nerve fiber layer of retina | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04471","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two retinal structures are connected to the inner plexiform layer of the retina via an 'adjacent to' relationship and are bo... | |
medium_hidden_intermediate_04473 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene is upregulated and involved in the negative regulation of tumor necrosis factor-mediated signaling pathway. Evidence for this gene reports a log2 fold change of 1.246 and an adjusted p-value of 0.03861. Which p... | Baculoviral IAP repeat-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04473","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene is upregulated... | |
medium_hidden_intermediate_04474 | Pegivirus C is reported to downregulate a specific gene, which in turn participates in the regulation of CDH1 gene transcription. Experimental data from a study on peripheral blood mononuclear cells (GSE131504) indicates that this gene exhibits a log2 fold change of approximately -2.36 and an adjusted p-value of approx... | M-phase phosphoprotein 8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04474","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn participates in the regulation of CDH1 gene transcrip... | |
medium_hidden_intermediate_04475 | Pegivirus C is reported to downregulate a specific gene that is involved in the positive regulation of the mitotic cell cycle. Experimental data for this gene in peripheral blood mononuclear cells (study GSE131504) show a log2 fold change of -2.157 and an adjusted p-value of 0.0001522. Which disease is associated with ... | carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04475","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene that is involved in the positive regulation of the mitotic cell cycl... | |
medium_hidden_intermediate_04479 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to alcohol abuse via a 'biomarker' relationship. One of these genes is associated with a log2 fold change of -1.033 and an adjusted p-value of 0.001548 in a specific study context. Which mol... | phospholipid scramblase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04479","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_04480 | In a study of Influenza A virus infection, a specific gene is upregulated by the virus and subsequently binds to RPS27A. Experimental data for this gene reports a log2 fold change of approximately 1.562 and an adjusted p-value of 8.824e-05. Which gene interacts with this identified entity? | UBE2L3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04480","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is upregulated by the virus and subsequently binds to RPS27A. Exp... | |
medium_hidden_intermediate_04482 | Human immunodeficiency virus 1 is reported to downregulate a specific gene, which is in turn associated with endometrium adenocarcinoma. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately -1.754 and an adjusted p-value of 0.002111. Which protein is encoded by this gene? | Follistatin-related protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04482","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 is reported to downregulate a specific gene, which is in turn associated with endometrium ade... | |
medium_hidden_intermediate_04483 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Inositol phosphate metabolism. Evidence for one such gene reports a log2 fold change of 1.092 and an adjusted p-value of 0.003413. Which gene interacts with the gene identified by this evidence? | RALA | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04483","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Inositol phosphate metabolism.... | |
medium_hidden_intermediate_04485 | Two genes are upregulated by Human immunodeficiency virus 1 and both enable RNA binding. One of these genes exhibits a log2 fold change of 2.286 and an adjusted p-value of 0.007508 in macrophages (study GSE108897). Which disease is associated with this specific gene? | B-cell chronic lymphocytic leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04485","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and both enable RNA binding. One of these genes exhibits a log2 ... | |
medium_hidden_intermediate_04487 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and participates in Phase I - Functionalization of compounds. This gene exhibits a log2 fold change of approximately 3.98 and an adjusted p-value of approximately 0.009. Which protein is encoded by this gene? | Amine oxidase [copper-containing] 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04487","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and participat... | |
medium_hidden_intermediate_04490 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Neddylation. One of these genes exhibits a log2 fold change of 1.304 and an adjusted p-value of 0.002691 in a specific study. Which molecular function is enabled by this specific gene? | ubiquitin-like ligase-substrate adaptor activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04490","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Neddylation. One of th... | |
medium_hidden_intermediate_04491 | Pegivirus C downregulates a gene that subsequently interacts with RPS6. Experimental data for this intermediate gene in peripheral blood mononuclear cells (study GSE131504) shows a log2 fold change of -2.555 and an adjusted p-value of 0.03024. Which protein is encoded by this gene? | Nucleolar protein 8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04491","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that subsequently interacts with RPS6. Experimental data for this intermediate gene in peri... | |
medium_hidden_intermediate_04492 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is located in a vesicle. Experimental data for this gene reports a log2 fold change of 1.386 and an adjusted p-value of 0.0004633. Which molecular function is enabled by this gene? | G protein-coupled receptor activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04492","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is located in a vesicle. Experimental dat... | |
medium_hidden_intermediate_04493 | Zika virus downregulates a gene that is involved in protein autoubiquitination. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -1.597 and an adjusted p-value of 0.02126. Which protein is encoded by this specific gene? | Bifunctional apoptosis regulator | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04493","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in protein autoubiquitination. In a study of glioma stem cells (GSE114907),... | |
medium_hidden_intermediate_04494 | Human immunodeficiency virus 1 upregulates a gene that participates in cellular responses to stress. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of 7.171 and an adjusted p-value of 0.003113. Which protein is encoded by this gene? | Cyclin-A1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04494","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in cellular responses to stress. In a study of macrophag... | |
medium_hidden_intermediate_04496 | Pegivirus C downregulates a gene that participates in carboxyterminal post-translational modifications of tubulin. Evidence for this gene in peripheral blood mononuclear cells (study GSE131504) reports a log2 fold change of -1.426 and an adjusted p-value of 0.002935. Which cellular component is this gene located in? | microtubule | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04496","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that participates in carboxyterminal post-translational modifications of tubulin. Evidence ... | |
medium_hidden_intermediate_04497 | Zika virus downregulates a gene that is involved in the regulation of DNA-templated transcription. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -2.846 and an adjusted p-value of 0.02381. Which protein is encoded by this specific gene? | Zinc finger protein 398 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04497","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the regulation of DNA-templated transcription. In a study of glioma stem... | |
medium_hidden_intermediate_04498 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a downregulation relationship and to adult glioblastoma via a biomarker relationship. One of these genes is associated with a log2 fold change of approximately -1.93 and an adjusted p-value of approximately 0.0031. Which prot... | Cell adhesion molecule CEACAM3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04498","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a downregulation relationship... | |
medium_hidden_intermediate_04501 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and to PEX14 via a 'binds' relationship. One of these genes has an associated expression profile in lung cells showing a log2 fold change of approximately 2.10 and an adjusted p-value of 0.0371. ... | Bifunctional epoxide hydrolase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04501","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship... | |
medium_hidden_intermediate_04502 | Two genes are upregulated by Human immunodeficiency virus 1 and participate in Signaling by Rho GTPases, Miro GTPases and RHOBTB3. One of these genes exhibits a log2 fold change of approximately 1.102 and an adjusted p-value of 0.001086 in macrophages (study GSE108897). Which disease is associated with this specific ge... | neurodevelopmental disorder with structural brain anomalies and dysmorphic facies | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04502","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and participate in Signaling by Rho GTPases, Miro GTPases and RH... | |
medium_hidden_intermediate_04504 | Hepacivirus C is reported to downregulate a gene that subsequently binds to BBS5. In a specific study, this intermediate gene exhibited a log2 fold change of -1.110 and an adjusted p-value of 5.095e-05. Which protein is encoded by this intermediate gene? | ADP-ribosylation factor-like protein 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04504","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that subsequently binds to BBS5. In a specific study, this intermediate gen... | |
medium_hidden_intermediate_04505 | Measles morbillivirus downregulates a gene that participates in Complex IV assembly. Experimental data for this gene shows a log2 fold change of -1.472 and an adjusted p-value of 0.001312. Which biological process is this gene involved in? | mitochondrial respiratory chain complex IV assembly | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04505","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus downregulates a gene that participates in Complex IV assembly. Experimental data for this gene shows a... | |
medium_hidden_intermediate_04506 | Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to Membrane Trafficking via a participation relationship. One of these genes exhibits a log2 fold change of -1.302 and an adjusted p-value of 0.006781 in macrophages (study GSE108897). Which disease is associated w... | Wilson disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04506","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to Membrane Traffi... | |
medium_hidden_intermediate_04509 | PSMA1 is involved in a biological process that is a subtype of T-helper cell differentiation. Evidence for one such process describes it as the mechanism by which a relatively unspecialized T cell acquires the specialized features of a specific T-helper cell subtype, characterized as a CD4-positive, alpha-beta T cell w... | T-helper 17 cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04509","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"PSMA1 is involved in a biological process that is a subtype of T-helper cell differentiation. Evidence for one such process ... | |
medium_hidden_intermediate_04512 | Pegivirus C is reported to downregulate a specific gene, which is subsequently involved in the positive regulation of transcription by RNA polymerase II. Experimental data for this gene indicates a log2 fold change of -1.203 and an adjusted p-value of 0.006815. In which cell type is this gene enriched? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04512","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which is subsequently involved in the positive regulation of transc... | |
medium_hidden_intermediate_04513 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and its protein product is located in the mitochondrial intermembrane space. Transcriptomic data for this gene shows a log2 fold change of approximately 2.14 and an adjusted p-value of 0.014. Which biological process is this gene involved in... | mitochondrial respiratory chain complex IV assembly | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04513","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and its protein product is located in the mit... | |
medium_hidden_intermediate_04514 | In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and interacts with YWHAG. This specific gene exhibits a log2 fold change of approximately 1.27 and an adjusted p-value of 0.0474. Which protein is encoded by this gene? | Transcriptional regulator Kaiso | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04514","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and interacts w... | |
medium_hidden_intermediate_04516 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are located in the centriolar satellite. One of these genes exhibits a log2 fold change of approximately 1.14 and an adjusted p-value of approximately 0.032 in a specific study. Which biological process is this specific gene involved... | cilium assembly | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04516","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are located in the centriolar satelli... | |
medium_hidden_intermediate_04517 | A gene is downregulated by Human immunodeficiency virus 1 and is involved in protein ubiquitination. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of approximately -1.295 and an adjusted p-value of 0.03705. Which disease is associated with genomic alterations in this gene? | Seckel syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04517","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Human immunodeficiency virus 1 and is involved in protein ubiquitination. Evidence for this gene ... | |
medium_hidden_intermediate_04518 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene that enables ATP binding. This gene exhibited a log2 fold change of -1.418 and an adjusted p-value of 0.009157. Which protein is encoded by this gene? | PX domain-containing protein kinase-like protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04518","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene that enables... | |
medium_hidden_intermediate_04519 | Human betaherpesvirus 5 is reported to downregulate a gene that participates in biological oxidations. In a study using foreskin fibroblast cell lines, one such gene exhibited a log2 fold change of -1.843 and an adjusted p-value of 0.02933. Which protein is encoded by this specific gene? | Carboxymethylenebutenolidase homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04519","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that participates in biological oxidations. In a study using fore... | |
medium_hidden_intermediate_04521 | Human betaherpesvirus 5 is reported to downregulate a specific gene, the product of which is located in blood microparticles. Experimental data for this gene in foreskin fibroblast cell lines (study GSE132081) show a log2 fold change of approximately -1.041 and an adjusted p-value of 0.009176. Which protein does this g... | APOA1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04521","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a specific gene, the product of which is located in blood microparticles... | |
medium_hidden_intermediate_04523 | Pegivirus C is reported to downregulate a gene that subsequently interacts with TOP3B. Experimental data for one such intermediate gene in peripheral blood mononuclear cells (study GSE131504) shows a log2 fold change of -2.325 and an adjusted p-value of 0.0002127. Which protein is encoded by this specific gene? | Ankyrin repeat domain-containing protein 17 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04523","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that subsequently interacts with TOP3B. Experimental data for one such interm... | |
medium_hidden_intermediate_04525 | Enterovirus A is reported to upregulate a specific gene, which is in turn enriched in conventional dendritic cells. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) indicates a log2 fold change of approximately 1.064 and an adjusted p-value of 0.01004. Which protein is encoded by this gene? | Protein FAM135A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04525","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is reported to upregulate a specific gene, which is in turn enriched in conventional dendritic cells. Experime... | |
medium_hidden_intermediate_04527 | Two genes are structurally linked to EGF via a 'binds' interaction and subsequently linked to the molecular function 'protein binding' via an 'enables' relationship. One of these genes is characterized by evidence stating that three crystal structures of the gene product in complex with HER2 phospho-peptides revealed t... | endometrial carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04527","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to EGF via a 'binds' interaction and subsequently linked to the molecular function 'protei... | |
medium_hidden_intermediate_04528 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables sodium channel regulator activity. Experimental data for this gene in choroid plexus epithelium (study GSE157852) shows a log2 fold change of 2.319 and an adjusted p-value of 0.003158. Which disease is associated with this gene? | cervical cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04528","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables sodium channel regulator activity... | |
medium_hidden_intermediate_04529 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are located in the basolateral plasma membrane. One of these genes exhibits a log2 fold change of 1.465 and an adjusted p-value of 0.01058 in a specific study. Which disease is associated with this gene as a biomarker? | head and neck cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04529","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are located in the basolateral plasma... | |
medium_hidden_intermediate_04530 | Zika virus downregulates a gene that is located in the extracellular space. In a study of glioma stem cells (GSE114907), one such gene exhibits a log2 fold change of -3.894 and an adjusted p-value of 0.003552. Which molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04530","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in the extracellular space. In a study of glioma stem cells (GSE114907), one... | |
medium_hidden_intermediate_04532 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated by the virus and its product interacts with ACTB. Evidence for this gene reports a log2 fold change of 1.020 and an adjusted p-value of 0.01936. Which protein is encoded by this gene? | Leucine-rich repeat-containing protein 20 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04532","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated by the virus a... | |
medium_hidden_intermediate_04533 | Two genes are upregulated by Influenza A virus and both enable identical protein binding. One of these genes exhibits a log2 fold change of approximately 1.248 and an adjusted p-value of 0.006613 in non-small cell lung adenocarcinoma cell lines. Which disease is associated with genomic alterations in this specific gene... | lupus vulgaris | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04533","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Influenza A virus and both enable identical protein binding. One of these genes exhibits a log2... | |
medium_hidden_intermediate_04534 | Pegivirus C is reported to downregulate a gene that subsequently binds to SRSF2. Experimental data for this intermediate gene in peripheral blood mononuclear cells (from study GSE131504) show a log2 fold change of approximately -1.106 and an adjusted p-value of 0.03293. Which protein is encoded by this gene? | Cleavage and polyadenylation specificity factor subunit 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04534","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that subsequently binds to SRSF2. Experimental data for this intermediate gen... | |
medium_hidden_intermediate_04536 | In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to downregulate a specific gene, which in turn participates in protein-protein interactions at synapses. The expression data for this gene shows a log2 fold change of -1.191 and an adjusted p-value of 0.... | Leucine-rich repeat transmembrane neuronal protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04536","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to down... | |
medium_hidden_intermediate_04537 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene, which in turn participates in the RAF/MAP kinase cascade. This gene exhibited a log2 fold change of 1.729 and an adjusted p-value of 0.0003637. Which protein is encoded by this gene? | Progestin and adipoQ receptor family member 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04537","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene, which in ... | |
medium_hidden_intermediate_04538 | In a study of Measles morbillivirus infection, two genes are identified as being upregulated by the virus and enriched in conventional dendritic cells. One of these genes exhibits a log2 fold change of approximately 1.166 and an adjusted p-value of 0.02703. Which protein is encoded by this specific gene? | Oxysterol-binding protein-related protein 11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04538","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, two genes are identified as being upregulated by the virus and enriched in co... | |
medium_hidden_intermediate_04539 | Zika virus downregulates a gene that is associated with lymphoma. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -2.80 and an adjusted p-value of 0.0209. Which protein is encoded by this gene? | BMP-binding endothelial regulator protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04539","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is associated with lymphoma. In a study of glioma stem cells (GSE114907), this gene exh... | |
medium_hidden_intermediate_04541 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with MBD3. One of these genes exhibits a log2 fold change of 1.259 and an adjusted p-value of 0.031 in a specific study. Which disease is associated with this gene? | kuru | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04541","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with MBD3. One of these gene... | |
medium_hidden_intermediate_04542 | Hepacivirus C upregulates a gene that participates in the Innate Immune System. Evidence for one such gene reports a log2 fold change of 1.989 and an adjusted p-value of 0.02211. Which protein is encoded by that gene? | Alpha-1B-glycoprotein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04542","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in the Innate Immune System. Evidence for one such gene reports a log2 fo... | |
medium_hidden_intermediate_04543 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in protein ubiquitination. One of these genes exhibits a log2 fold change of 2.214 and an adjusted p-value of 0.01964 in choroid plexus epithelium. Which disease is associated with this specific gene as a biomarker? | Squamous cell carcinoma of the head and neck | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04543","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in protein ubiquitinatio... | |
medium_hidden_intermediate_04544 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via downregulation and to malignant colon neoplasm via biomarker association. One of these genes exhibits a log2 fold change of approximately -1.01 and an adjusted p-value of 0.017 in a specific study. Which disease is associated with this sp... | carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04544","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via downregulation and to malignant colon neop... | |
medium_hidden_intermediate_04546 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and involved in the apoptotic signaling pathway. This gene exhibits a log2 fold change of approximately 1.299 and an adjusted p-value of 4.927e-12. Which protein is encoded by this gene? | Modulator of apoptosis 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04546","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and i... | |
medium_hidden_intermediate_04547 | Two genes are downregulated by Human immunodeficiency virus 1 and are involved in the positive regulation of transcription by RNA polymerase II. One of these genes exhibits a log2 fold change of approximately -1.315 and an adjusted p-value of 0.02125 in macrophages (study GSE108897). Which disease is associated with ge... | prostate cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04547","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Human immunodeficiency virus 1 and are involved in the positive regulation of transcription b... | |
medium_hidden_intermediate_04548 | Zika virus downregulates a gene that participates in Neddylation. Transcriptomic data from glioma stem cells (study GSE114907) indicates that this specific gene has a log2 fold change of -1.835 and an adjusted p-value of 0.01409. Which protein is encoded by this gene? | Kelch-like protein 22 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04548","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in Neddylation. Transcriptomic data from glioma stem cells (study GSE11490... | |
medium_hidden_intermediate_04549 | Vaccinia virus upregulates a gene that is involved in fatty acid beta-oxidation. In a study of cervical adenocarcinoma cell lines (GSE11238), this gene exhibited a log2 fold change of 2.289 and an adjusted p-value of 5.327e-08. Which disease is associated with this gene as a biomarker? | cervical carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04549","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a gene that is involved in fatty acid beta-oxidation. In a study of cervical adenocarcinoma cell ... | |
medium_hidden_intermediate_04550 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Diseases of signal transduction by growth factor receptors and second messengers. Evidence for this gene in choroid plexus epithelium (study GSE157852) reports a log2 fold change of approximately -1.102 and an adjusted ... | stroke disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04550","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Diseases of signal tran... | |
medium_hidden_intermediate_04552 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and involved in the negative regulation of cytoplasmic translation. Evidence for this gene reports a log2 fold change of approximately 1.06 and an adjusted p-value of 0.0384. Which protein is encoded by this ge... | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04552","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and involved i... | |
medium_hidden_intermediate_04553 | Zika virus downregulates a gene that is involved in the regulation of the cell cycle. Evidence for this specific gene in glioma stem cells (study GSE114907) reports a log2 fold change of -1.842 and an adjusted p-value of 0.01525. Which protein is encoded by this gene? | Proline-rich protein 11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04553","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the regulation of the cell cycle. Evidence for this specific gene in gli... | |
medium_hidden_intermediate_04554 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Signaling by WNT. One of these genes exhibits a log2 fold change of 1.693 and an adjusted p-value of 0.006233 in a specific study. Which molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04554","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Signaling by WNT. One ... | |
medium_hidden_intermediate_04555 | Two genes are structurally linked to Enterovirus A via downregulation and to the gel phase of the interstitial matrix via location. One of these genes exhibits a log2 fold change of -2.187 and an adjusted p-value of 0.000889 in rhabdomyosarcoma cells. Which disease is associated with this specific gene through genomic ... | posterior amorphous corneal dystrophy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04555","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Enterovirus A via downregulation and to the gel phase of the interstitial matrix via lo... | |
medium_hidden_intermediate_04556 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of certain genes that are subsequently found in the extracellular space. One such gene exhibits a log2 fold change of approximately 3.05 and an adjusted p-value of 0.0259. What molecular function is enabled by this speci... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04556","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of certain genes that ar... | |
medium_hidden_intermediate_04557 | Hepacivirus C is associated with the downregulation of a specific gene, which in turn enables kinase binding. Experimental data for this gene reports a log2 fold change of approximately -1.06 and an adjusted p-value of 0.00759. Which protein is encoded by this gene? | WD repeat and coiled-coil-containing protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04557","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is associated with the downregulation of a specific gene, which in turn enables kinase binding. Experimental d... | |
medium_hidden_intermediate_04558 | Codeine and Ketoconazole are both known to interact with a specific intermediate drug. Pharmacokinetic evidence indicates that coadministration of this intermediate drug with ketoconazole (a CYP3A4 inhibitor) increases the intermediate drug's area under the concentration-time curve (AUC(0-∞)) by 54% and decreases its m... | epilepsy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04558","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Codeine and Ketoconazole are both known to interact with a specific intermediate drug. Pharmacokinetic evidence indicates th... | |
medium_hidden_intermediate_04561 | Human betaherpesvirus 5 upregulates a gene that participates in the metabolism of lipids. Evidence for this specific gene reports a log2 fold change of 1.233 and an adjusted p-value of 0.03428. Which biological process is this gene involved in? | N-acylphosphatidylethanolamine metabolic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04561","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that participates in the metabolism of lipids. Evidence for this specific gene re... | |
medium_hidden_intermediate_04564 | Human immunodeficiency virus 1 downregulates a gene that is involved in the negative regulation of DNA-templated transcription. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of approximately -1.29 and an adjusted p-value of approximately 0.021. Which protein is encoded by this specif... | Protein lin-52 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04564","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is involved in the negative regulation of DNA-templated transcripti... | |
medium_hidden_intermediate_04565 | Zika virus upregulates a gene that is involved in the regulation of transcription by RNA polymerase II. Experimental data for this gene reports a log2 fold change of 1.117 and an adjusted p-value of 0.0102. Which protein is encoded by this gene? | Krueppel-like factor 9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04565","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that is involved in the regulation of transcription by RNA polymerase II. Experimental data fo... | |
medium_hidden_intermediate_04568 | Pegivirus C downregulates a gene that interacts with TRIM27. Evidence for one such gene reports a log2 fold change of -1.162 and an adjusted p-value of 0.04071. Which protein is encoded by that gene? | Protein CLEC16A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04568","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that interacts with TRIM27. Evidence for one such gene reports a log2 fold change of -1.162... | |
medium_hidden_intermediate_04569 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables ATP binding. Experimental data for this gene in lung cells show a log2 fold change of approximately 1.246 and an adjusted p-value of 0.03861. Which cellular component is this gene located in? | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04569","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables ATP binding. Experimental data fo... | |
medium_hidden_intermediate_04573 | In a study of macrophages (GSE108897), a gene is identified that is upregulated by Human immunodeficiency virus 1 and participates in the Apoptotic execution phase. This specific gene exhibits a log2 fold change of 1.076 and an adjusted p-value of 0.03145. Which protein is encoded by this gene? | Alpha-adducin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04573","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is upregulated by Human immunodeficiency virus 1 and partic... | |
medium_hidden_intermediate_04576 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables GTPase activator activity. Experimental data for this gene shows a log2 fold change of -1.404 and an adjusted p-value of 0.001424. In which cell type is this gene enriched? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04576","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables GTPase activator activity. Expe... | |
medium_hidden_intermediate_04577 | In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and participates in SARS-CoV-2 Infection. This specific gene exhibits a log2 fold change of -4.063 and an adjusted p-value of 0.04063. What molecular function is enabled by this gene? | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04577","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and part... | |
medium_hidden_intermediate_04580 | Two genes are expressed in macrophages and enable identical protein binding. One of these genes has a dimer solution structure that was solved by NMR spectroscopy. Which disease is associated with this specific gene as a biomarker? | ulcer disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04580","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are expressed in macrophages and enable identical protein binding. One of these genes has a dimer solution structu... | |
medium_hidden_intermediate_04583 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that subsequently interacts with TRIM33. One such gene exhibits a log2 fold change of 2.495 and an adjusted p-value of 0.0002165. Which protein is encoded by this specific gene? | Paraneoplastic antigen Ma2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04583","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that subsequently interacts with TR... | |
medium_hidden_intermediate_04585 | Pegivirus C downregulates a gene that participates in cell-cell junction organization. In a study of peripheral blood mononuclear cells (GSE131504), one such gene showed a log2 fold change of approximately -1.17 and an adjusted p-value of 0.0023. Which protein is encoded by this specific gene? | Transcriptional regulator Kaiso | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04585","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that participates in cell-cell junction organization. In a study of peripheral blood mononu... | |
medium_hidden_intermediate_04586 | Zika virus downregulates a gene that participates in glucose metabolism. In glioma stem cells, this gene exhibits a log2 fold change of -3.093 and an adjusted p-value of 0.01269. Which molecular function is enabled by this gene? | glucokinase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04586","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in glucose metabolism. In glioma stem cells, this gene exhibits a log2 fol... | |
medium_hidden_intermediate_04587 | In a study involving Human gammaherpesvirus 8, a specific gene is downregulated by the virus and is known to enable zinc ion binding. Experimental data for this gene reports a log2 fold change of -1.335 and an adjusted p-value of 0.03577. Which protein is encoded by this gene? | Glutaminyl-peptide cyclotransferase-like protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04587","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study involving Human gammaherpesvirus 8, a specific gene is downregulated by the virus and is known to enable zinc ion... | |
medium_hidden_intermediate_04588 | In a study of glioma stem cells (GSE114907), Zika virus infection leads to the downregulation of a specific gene, which in turn encodes a protein that binds to SCO1. The expression data for this gene shows a log2 fold change of -1.104 and an adjusted p-value of 0.02755. Which protein is encoded by this gene? | Cytochrome c oxidase assembly factor 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04588","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), Zika virus infection leads to the downregulation of a specific gene, which in t... | |
medium_hidden_intermediate_04591 | Human immunodeficiency virus 1 upregulates a gene that participates in the activation of gene expression by SREBF (SREBP). Evidence for this specific gene reports a log2 fold change of 1.020 and an adjusted p-value of 0.000213. Which cellular component is this gene located in? | peroxisome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04591","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in the activation of gene expression by SREBF (SREBP). E... | |
medium_hidden_intermediate_04593 | In a study of rhabdomyosarcoma cells (GSE103308), a specific gene is upregulated by Enterovirus A and associated with retinal degeneration. This gene exhibits a log2 fold change of approximately 2.90 and an adjusted p-value of approximately 0.0019. Which biological process is this gene involved in? | regulation of transcription by RNA polymerase II | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04593","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), a specific gene is upregulated by Enterovirus A and associated with retina... | |
medium_hidden_intermediate_04594 | POGZ interacts with a gene product that enables protein binding. Evidence indicates that this gene product, along with ZXDA, can self-associate and form a complex with each other. Which gene interacts with this specific gene product? | FBXO38 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04594","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"POGZ interacts with a gene product that enables protein binding. Evidence indicates that this gene product, along with ZXDA,... | |
medium_hidden_intermediate_04595 | FZD8 interacts with a specific protein that possesses protein binding activity. Evidence indicates that this protein also binds to Dishevelled, thereby activating the canonical Wnt pathway and serving as a link between Wnt signaling and Dishevelled. Which disease is associated with this protein through genomic alterati... | cleft palate | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04595","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"FZD8 interacts with a specific protein that possesses protein binding activity. Evidence indicates that this protein also bi... | |
medium_hidden_intermediate_04596 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that enables all-trans-retinol dehydrogenase (NAD+) activity. One such gene exhibits a log2 fold change of approximately 6.37 and an adjusted p-value of 0.0142. Which protein is encoded by this specific gene? | All-trans-retinol dehydrogenase [NAD(+)] ADH1B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04596","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that enables all-trans-retinol dehy... | |
medium_hidden_intermediate_04597 | Human alphaherpesvirus 1 upregulates a gene that participates in SUMOylation. In a study of monocytic leukemia cell lines (GSE114966), one such gene showed a log2 fold change of 2.865 and an adjusted p-value of 0.003427. Which protein is encoded by this gene? | Borealin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04597","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that participates in SUMOylation. In a study of monocytic leukemia cell lines (G... | |
medium_hidden_intermediate_04598 | Two genes are upregulated by Enterovirus A and participate in Sphingolipid metabolism. One of these genes shows a log2 fold change of 1.174 and an adjusted p-value of 0.001103 in rhabdomyosarcoma cells. Which disease is associated with this specific gene? | hemochromatosis type 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04598","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Enterovirus A and participate in Sphingolipid metabolism. One of these genes shows a log2 fold ... | |
medium_hidden_intermediate_04599 | Two genes are structurally linked to Pegivirus C via downregulation and to GTF2F2 via binding. One of these genes exhibits a log2 fold change of -1.794 and an adjusted p-value of 0.0001999 in peripheral blood mononuclear cells. Which disease is associated with this specific gene? | leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04599","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Pegivirus C via downregulation and to GTF2F2 via binding. One of these genes exhibits a... | |
medium_hidden_intermediate_04600 | Zika virus downregulates a specific gene that participates in protein localization. Experimental data for this gene in glioma stem cells (from study GSE114907) reports a log2 fold change of -2.476 and an adjusted p-value of 0.01635. In which cell type is this gene enriched? | non-classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04600","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in protein localization. Experimental data for this gene in gliom... | |
medium_hidden_intermediate_04601 | Pegivirus C downregulates a gene that participates in the CDC42 GTPase cycle. Experimental data from peripheral blood mononuclear cells (study GSE131504) indicate that this gene has a log2 fold change of -2.221 and an adjusted p-value of 0.04971. Which protein is encoded by this gene? | Copine-8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04601","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that participates in the CDC42 GTPase cycle. Experimental data from peripheral blood mononu... | |
medium_hidden_intermediate_04603 | Two genes are structurally linked to TRAF2 via an 'interacts with' relationship and subsequently linked to 'tumor necrosis factor receptor activity' via an 'enables' relationship. One of these genes is associated with a protein that interacts with TRAF1, TRAF2, and TRAF3, and induces NF-kappaB activation via TRAF2. Whi... | Tumor necrosis factor receptor superfamily member 18 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04603","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to TRAF2 via an 'interacts with' relationship and subsequently linked to 'tumor necrosis f... | |
medium_hidden_intermediate_04604 | In studies of Severe acute respiratory syndrome-related coronavirus infection, certain genes are downregulated and subsequently interact with CASP1. One such gene exhibits a log2 fold change of approximately -2.56 and an adjusted p-value of approximately 0.0099. Which protein is encoded by this specific gene? | Interleukin-1 beta | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04604","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In studies of Severe acute respiratory syndrome-related coronavirus infection, certain genes are downregulated and subsequen... | |
medium_hidden_intermediate_04606 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to male infertility via association. One of these genes exhibits a log2 fold change of approximately 1.21 and an adjusted p-value of 0.0058 in a specific study. Which protein is encoded by this gene? | Parkin coregulated gene protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04606","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to male infertility via a... | |
medium_hidden_intermediate_04607 | Pegivirus C is reported to downregulate a gene that enables cysteine-type deubiquitinase activity. Evidence for one such gene indicates a log2 fold change of -1.543 and an adjusted p-value of 0.01109. Which disease is associated with this gene as a biomarker? | major depressive disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04607","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that enables cysteine-type deubiquitinase activity. Evidence for one such gen... | |
medium_hidden_intermediate_04608 | Zika virus downregulates a gene that is involved in the proteasome-mediated ubiquitin-dependent protein catabolic process. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -1.022 and an adjusted p-value of 0.0188. Which protein is encoded by this specific gene? | Adapter SH3BGRL | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04608","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the proteasome-mediated ubiquitin-dependent protein catabolic process. I... | |
medium_hidden_intermediate_04610 | Enterovirus A downregulates a specific gene that is involved in the positive regulation of osteoblast differentiation. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) reports a log2 fold change of approximately -2.515 and an adjusted p-value of 0.0001426. Which cellular component is this gen... | extracellular space | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04610","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A downregulates a specific gene that is involved in the positive regulation of osteoblast differentiation. Exper... | |
medium_hidden_intermediate_04613 | Zika virus downregulates a gene that participates in neutrophil degranulation. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of approximately -1.89 and an adjusted p-value of 0.0155. Which protein is encoded by this specific gene? | ORM1-like protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04613","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in neutrophil degranulation. In a study of glioma stem cells (GSE114907), ... | |
medium_hidden_intermediate_04614 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to mammary neoplasms, animal via an 'associated with' relationship. One of these genes has experimental evidence showing a log2 fold change of -2.649 and an adjusted p-value of 0.0006686. Wh... | Differentially expressed in FDCP 6 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04614","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_04615 | In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and is involved in protein K63-linked ubiquitination. This specific gene exhibits a log2 fold change of 1.584 and an adjusted p-value of 0.008217. Which protein is encoded by this gene? | E3 ubiquitin-protein ligase TRIM65 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04615","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and is involved in protein K6... | |
medium_hidden_intermediate_04617 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in host-mediated suppression of symbiont invasion. Evidence for this gene reports a log2 fold change of -2.596 and an adjusted p-value of 0.0004572. Which protein is encoded by this gene? | Pentraxin-related protein PTX3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04617","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in host-mediated suppression of ... | |
medium_hidden_intermediate_04620 | Zika virus downregulates a specific gene, which is subsequently associated with carcinoma. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -1.986 and an adjusted p-value of 0.006285. Which disease is linked to this gene as a biomarker? | ganglioglioma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04620","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which is subsequently associated with carcinoma. Experimental data for this gene i... | |
medium_hidden_intermediate_04621 | A gene is upregulated by Primate bocaparvovirus 1 and enriched in intermediate monocytes. Evidence for this gene reports a log2 fold change of 4.129 and an adjusted p-value of 0.02962. Which biological process is this gene involved in? | defense response to virus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04621","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and enriched in intermediate monocytes. Evidence for this gene reports a l... | |
medium_hidden_intermediate_04623 | Hepacivirus C upregulates a gene that participates in Signaling by Interleukins. Evidence for this gene reports a log2 fold change of 1.090 and an adjusted p-value of 0.02584. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04623","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in Signaling by Interleukins. Evidence for this gene reports a log2 fold ... |
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