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medium_hidden_intermediate_04625 | Human alphaherpesvirus 1 upregulates a gene that participates in metabolism. Evidence for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately 1.054 and an adjusted p-value of 0.003685. Which protein is encoded by this gene? | Gamma-glutamylcyclotransferase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04625","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that participates in metabolism. Evidence for this gene in a monocytic leukemia ... | |
medium_hidden_intermediate_04626 | Cardiovirus A downregulates a specific gene, which in turn interacts with HIST1H3A. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of -1.836 and an adjusted p-value of 0.02787. Which protein is encoded by this gene? | PH-interacting protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04626","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A downregulates a specific gene, which in turn interacts with HIST1H3A. Experimental data for this gene in a cer... | |
medium_hidden_intermediate_04628 | Vaccinia virus upregulates a specific gene that is also associated with hepatocellular carcinoma through genomic alterations. In a study using a cervical adenocarcinoma cell line (GSE11238), this gene exhibited a log2 fold change of approximately 2.355 and an adjusted p-value of 3.711e-09. Which disease is linked to th... | atopic eczema | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04628","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a specific gene that is also associated with hepatocellular carcinoma through genomic alterations... | |
medium_hidden_intermediate_04629 | In a study of glioma stem cells (GSE114907), Zika virus infection leads to the downregulation of a specific gene, which in turn interacts with TFRC. One such downregulated gene exhibits a log2 fold change of -2.826 and an adjusted p-value of 0.04195. Which protein is encoded by this specific gene? | RAB11-binding protein RELCH | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04629","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), Zika virus infection leads to the downregulation of a specific gene, which in t... | |
medium_hidden_intermediate_04630 | Zika virus downregulates a gene that enables calcium-dependent protein binding. In glioma stem cells, this gene exhibits a log2 fold change of -2.583 and an adjusted p-value of 0.004071. Which protein is encoded by this gene? | Programmed cell death 6-interacting protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04630","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that enables calcium-dependent protein binding. In glioma stem cells, this gene exhibits a l... | |
medium_hidden_intermediate_04631 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in Phospholipid metabolism. One such gene exhibits a log2 fold change of 2.027 and an adjusted p-value of 0.001665. Which protein is encoded by this specific gene? | Pleckstrin homology domain-containing family A member 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04631","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in Phospholipid m... | |
medium_hidden_intermediate_04634 | In a study of glioma stem cells (GSE114907), Zika virus infection leads to the downregulation of a specific gene, which subsequently interacts with UXT. This gene exhibits a log2 fold change of -2.516 and an adjusted p-value of 0.003971. What molecular function is enabled by this gene? | chromatin binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04634","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), Zika virus infection leads to the downregulation of a specific gene, which subs... | |
medium_hidden_intermediate_04635 | Zika virus downregulates a gene that participates in gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation. Evidence from a study on glioma stem cells (GSE114907) reports that this gene has a log2 fold change of -1.707 and an adjusted p-value of 0.00474. Which protein is encoded by this gene? | Zinc finger CCCH domain-containing protein 15 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04635","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase a... | |
medium_hidden_intermediate_04637 | In a study of bronchial epithelial cells, a gene upregulated by Severe acute respiratory syndrome-related coronavirus and involved in angiogenesis showed a log2 fold change of 1.009 and an adjusted p-value of 0.01247. Which protein is encoded by this gene? | G-protein coupled receptor 15 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04637","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of bronchial epithelial cells, a gene upregulated by Severe acute respiratory syndrome-related coronavirus and in... | |
medium_hidden_intermediate_04638 | A gene is upregulated by Vaccinia virus and located in the basolateral plasma membrane. Evidence for this gene in a specific study reports a log2 fold change of 2.593 and an adjusted p-value of 2.753e-05. Which cell type is this gene enriched in? | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04638","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Vaccinia virus and located in the basolateral plasma membrane. Evidence for this gene in a specific... | |
medium_hidden_intermediate_04639 | Cyproheptadine interacts with two different drugs, both of which also interact with Sodium sulfate. One of these drugs is mentioned in a clinical context where a dog was treated with ILE, cyproheptadine, and activated charcoal. Which disease is the drug associated with that fits this clinical description indicated for? | fibromyalgia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04639","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cyproheptadine interacts with two different drugs, both of which also interact with Sodium sulfate. One of these drugs is me... | |
medium_hidden_intermediate_04640 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the cellular response to chemical stress. Evidence for this gene reports a log2 fold change of approximately 1.69 and an adjusted p-value of approximately 0.00047. In which cell type is this gene enriched? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04640","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the cellular response to ... | |
medium_hidden_intermediate_04641 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to gastric cancer as biomarkers. One of these genes is associated with a log2 fold change of 2.836 and an adjusted p-value of 4.649e-05. Which protein is encoded by this specific gene? | Ceramide synthase 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04641","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to gastric cancer as biom... | |
medium_hidden_intermediate_04643 | In a study of Influenza A virus infection, a specific gene is downregulated by the virus and is involved in the negative regulation of cell population proliferation. Experimental data for this gene reports a log2 fold change of -1.594 and an adjusted p-value of 0.01874. Which cellular component is this gene located in? | CCR4-NOT complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04643","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is downregulated by the virus and is involved in the negative reg... | |
medium_hidden_intermediate_04645 | Pegivirus C is reported to downregulate a gene whose product is located in the endosome membrane. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.122 and an adjusted p-value of 0.02043. Which protein is encoded by this specific gene? | COMM domain-containing protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04645","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene whose product is located in the endosome membrane. In a study of peripheral b... | |
medium_hidden_intermediate_04646 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene that subsequently interacts with KRAS. This gene exhibited a log2 fold change of 1.876 and an adjusted p-value of 8.556e-06. Which cellular component is this gene located in? | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04646","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_04648 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Transmission across Chemical Synapses. Experimental data for this gene shows a log2 fold change of -1.126 and an adjusted p-value of 0.006475. Which cell type is this gene enriched in? | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04648","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Transmission across Che... | |
medium_hidden_intermediate_04649 | Hepacivirus C is reported to downregulate a specific gene, which in turn binds to UBC. Experimental data for this gene indicates a log2 fold change of -1.449 and an adjusted p-value of 0.0009877. In which cell type is this gene enriched? | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04649","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a specific gene, which in turn binds to UBC. Experimental data for this gene indic... | |
medium_hidden_intermediate_04650 | Zika virus downregulates a specific gene, which in turn interacts with XPO1. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -3.73 and an adjusted p-value of approximately 0.0059. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04650","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with XPO1. Experimental data for this gene in glioma stem ... | |
medium_hidden_intermediate_04651 | ANAPC11 binds to a specific protein that participates in DNA Replication. Evidence indicates that both APC11 and UbcH10 bind to the C-terminal cullin homology domain of this protein, whereas Ubc4 interacts with APC11 directly. Which gene encodes this protein? | Anaphase-promoting complex subunit 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04651","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"ANAPC11 binds to a specific protein that participates in DNA Replication. Evidence indicates that both APC11 and UbcH10 bind... | |
medium_hidden_intermediate_04654 | Zika virus downregulates a gene that subsequently binds to WDR43. In a study of glioma stem cells (GSE114907), one such intermediate gene exhibits a log2 fold change of -1.813 and an adjusted p-value of 0.02285. Which protein is encoded by this specific gene? | Nucleolar complex protein 4 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04654","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that subsequently binds to WDR43. In a study of glioma stem cells (GSE114907), one such inte... | |
medium_hidden_intermediate_04655 | Hepacivirus C upregulates a gene that participates in nervous system development. Evidence for one such gene reports a log2 fold change of 1.995 and an adjusted p-value of 0.0117. Which molecular function is enabled by that gene? | ubiquitin-like ligase-substrate adaptor activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04655","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in nervous system development. Evidence for one such gene reports a log2 ... | |
medium_hidden_intermediate_04659 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and its product is located in the Golgi apparatus. This gene exhibits a log2 fold change of approximately 1.79 and an adjusted p-value of 1.947e-06. Which protein is encoded by this gene? | LysM and putative peptidoglycan-binding domain-containing protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04659","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and i... | |
medium_hidden_intermediate_04661 | A gene is upregulated by Human immunodeficiency virus 1 and enriched in Regulatory T (Treg) cells. Evidence for this gene reports a log2 fold change of 1.086 and an adjusted p-value of 0.001814. Which disease is associated with this gene? | prostate cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04661","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human immunodeficiency virus 1 and enriched in Regulatory T (Treg) cells. Evidence for this gene re... | |
medium_hidden_intermediate_04662 | Two genes are each upregulated by Human immunodeficiency virus 1 and serve as biomarkers for glioblastoma. One of these genes exhibits a log2 fold change of 2.473 and an adjusted p-value of 0.00427 in macrophages (study GSE108897). Which protein interacts with this specific gene? | SIAH1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04662","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each upregulated by Human immunodeficiency virus 1 and serve as biomarkers for glioblastoma. One of these gene... | |
medium_hidden_intermediate_04663 | In a study of cervical adenocarcinoma cells (GSE11238), a gene upregulated by Vaccinia virus and associated with protein kinase binding activity showed a log2 fold change of approximately 1.36 and an adjusted p-value of 3.65e-06. Which cellular component is this gene located in? | nuclear pore nuclear basket | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04663","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), a gene upregulated by Vaccinia virus and associated with protein kin... | |
medium_hidden_intermediate_04665 | A gene is downregulated by Primate bocaparvovirus 1 and is associated with diabetes mellitus. Experimental data for this gene in umbilical vein endothelial cells (study GSE119608) reports a log2 fold change of approximately -2.03 and an adjusted p-value of approximately 0.014. Which protein is encoded by this gene? | Dipeptidyl peptidase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04665","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and is associated with diabetes mellitus. Experimental data for this gen... | |
medium_hidden_intermediate_04666 | In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and participates in factors involved in megakaryocyte development and platelet production. Evidence for this gene reports a log2 fold change of 2.213 and an adjusted p-value of 0.02347. Which protein is encoded by this gene? | Interferon regulatory factor 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04666","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and participates in factors invol... | |
medium_hidden_intermediate_04667 | Human alphaherpesvirus 1 upregulates a gene that is located in the extracellular exosome. Evidence for this specific gene reports a log2 fold change of 2.607 and an adjusted p-value of 0.01876. Which protein is encoded by this gene? | Thioredoxin domain-containing protein 16 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04667","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that is located in the extracellular exosome. Evidence for this specific gene re... | |
medium_hidden_intermediate_04669 | A gene is upregulated by Measles morbillivirus and is involved in spermatogenesis. Experimental evidence for this gene reports a log2 fold change of approximately 1.305 and an adjusted p-value of 0.0102. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04669","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and is involved in spermatogenesis. Experimental evidence for this gene repor... | |
medium_hidden_intermediate_04670 | Measles morbillivirus upregulates a gene that serves as a biomarker for hepatocellular carcinoma. Evidence for one such gene reports a log2 fold change of 2.978 and an adjusted p-value of 5.959e-05. Which biological process is this gene involved in? | cell adhesion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04670","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that serves as a biomarker for hepatocellular carcinoma. Evidence for one such gene... | |
medium_hidden_intermediate_04671 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus was found to upregulate a specific gene involved in DNA replication. This gene exhibited a log2 fold change of 2.792 and an adjusted p-value of 0.000913. Which protein is encoded by this gene? | Protein downstream neighbor of Son | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04671","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus was found to upregulate a specific gene involved... | |
medium_hidden_intermediate_04672 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes that subsequently bind to ITGA11. One such gene exhibits a log2 fold change of -3.236 and an adjusted p-value of 0.001165. Which protein is encoded by this specific gene? | Collagen alpha-1(XXI) chain | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04672","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes that ... | |
medium_hidden_intermediate_04674 | A gene product interacts with EIF4E and enables translation repressor activity. Evidence for this entity states: 'A similar motif is found in the amino acid sequence of the 4E-BPs, and point mutations in this motif abolish the interaction with eIF-4E.' Which gene interacts with this entity? | RPTOR | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04674","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene product interacts with EIF4E and enables translation repressor activity. Evidence for this entity states: 'A similar ... | |
medium_hidden_intermediate_04675 | Measles morbillivirus downregulates a gene that enables enzyme binding. Evidence for this gene reports a log2 fold change of -1.606 and an adjusted p-value of 0.04966. Which protein is encoded by this gene? | UDP-glucuronosyltransferase 1A6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04675","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus downregulates a gene that enables enzyme binding. Evidence for this gene reports a log2 fold change of... | |
medium_hidden_intermediate_04678 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and serves as a biomarker for breast carcinoma. Experimental data for this gene reports a log2 fold change of approximately -1.945 and an adjusted p-value of 0.04016. Which disease is associated with this gene through genomic alterations? | restless legs syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04678","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and serves as a biomarker for breast carcin... | |
medium_hidden_intermediate_04679 | NGFR interacts with a specific protein that enables protein binding. Evidence indicates that this interaction partner bound to dimeric p75(NTR), whereas TRAF2 interacted preferentially with monomeric p75(NTR). Which protein is encoded by the gene corresponding to this interaction partner? | TNF receptor-associated factor 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04679","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"NGFR interacts with a specific protein that enables protein binding. Evidence indicates that this interaction partner bound ... | |
medium_hidden_intermediate_04681 | Zika virus downregulates a gene that participates in tRNA processing. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -3.508 and an adjusted p-value of 0.007014. Which protein does this specific gene bind to? | WDR4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04681","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in tRNA processing. In a study of glioma stem cells (GSE114907), one such ... | |
medium_hidden_intermediate_04682 | Vaccinia virus downregulates a specific gene that subsequently interacts with YWHAH. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately -2.075 and an adjusted p-value of 0.001947. Which disease is associated with genomic alterations in thi... | lung cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04682","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus downregulates a specific gene that subsequently interacts with YWHAH. Experimental data for this gene in a ce... | |
medium_hidden_intermediate_04683 | Human betaherpesvirus 5 is reported to downregulate a gene that is enriched in intermediate monocytes. Evidence for this specific gene in foreskin fibroblast cell lines indicates a log2 fold change of approximately -1.52 and an adjusted p-value of 4.155e-08. Which protein is encoded by this gene? | Low-density lipoprotein receptor class A domain-containing protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04683","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that is enriched in intermediate monocytes. Evidence for this spe... | |
medium_hidden_intermediate_04685 | Two genes are structurally linked to CD247 via a 'binds' relationship and subsequently linked to 'MHC class II protein complex binding' via an 'enables' relationship. One of these genes is described by the following evidence: 'Here we provide evidence that in lysosomal compartments of B cells a considerable fraction of... | peptide antigen assembly with MHC class II protein complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04685","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to CD247 via a 'binds' relationship and subsequently linked to 'MHC class II protein compl... | |
medium_hidden_intermediate_04686 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with invasive breast carcinoma. One of these genes exhibits a log2 fold change of approximately 1.067 and an adjusted p-value of 0.02934 in lung cells. Which biological process is this specific gene involved in? | regulation of transcription by RNA polymerase II | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04686","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with invasive breast c... | |
medium_hidden_intermediate_04687 | Human immunodeficiency virus 1 upregulates a gene that subsequently binds to EIF4G1. Experimental data for this intermediate gene reports a log2 fold change of 1.036 and an adjusted p-value of 0.01131. Which protein is encoded by this gene? | CCR4-NOT transcription complex subunit 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04687","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that subsequently binds to EIF4G1. Experimental data for this intermediate... | |
medium_hidden_intermediate_04690 | Zika virus downregulates a gene that participates in the regulation of pyruvate metabolism. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.44 and an adjusted p-value of 0.0456. Which protein is encoded by this gene? | Glucose-induced degradation protein 4 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04690","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in the regulation of pyruvate metabolism. Experimental data for this gene ... | |
medium_hidden_intermediate_04691 | Two genes are downregulated by Human immunodeficiency virus 1 and interact with PARK2. One of these genes exhibits a log2 fold change of -1.121 and an adjusted p-value of 0.001361 in macrophages (study GSE108897). Which disease is associated with this specific gene? | developmental and epileptic encephalopathy, 82 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04691","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Human immunodeficiency virus 1 and interact with PARK2. One of these genes exhibits a log2 fo... | |
medium_hidden_intermediate_04693 | Two genes are downregulated by Pegivirus C and participate in organelle biogenesis and maintenance. One of these genes exhibits a log2 fold change of approximately -1.535 and an adjusted p-value of 0.005307 in peripheral blood mononuclear cells. Which cellular component is the location of this specific gene? | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04693","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and participate in organelle biogenesis and maintenance. One of these genes exhib... | |
medium_hidden_intermediate_04694 | Two genes are downregulated by Pegivirus C and interact with YWHAG. One of these genes exhibits a log2 fold change of -2.276 and an adjusted p-value of 0.004993 in peripheral blood mononuclear cells. Which biological process is this specific gene involved in? | regulation of DNA-templated transcription | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04694","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and interact with YWHAG. One of these genes exhibits a log2 fold change of -2.276... | |
medium_hidden_intermediate_04695 | Human immunodeficiency virus 1 upregulates a gene that participates in intracellular signaling by second messengers. Evidence for one such gene reports a log2 fold change of 2.131 and an adjusted p-value of 1.095e-05. Which disease is associated with that gene as a biomarker? | bipolar disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04695","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in intracellular signaling by second messengers. Evidenc... | |
medium_hidden_intermediate_04696 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to liver development via an 'involved in' relationship. One of these genes is associated with experimental data showing a log2 fold change of -1.264 and an adjusted p-value of 0.01863. Which... | Prospero homeobox protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04696","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_04697 | Two genes are structurally linked from Human immunodeficiency virus 1 to gastric cancer via a downregulation relationship followed by a biomarker association. One of these genes is reported in study GSE108897 with a log2 fold change of -1.841 and an adjusted p-value of 0.0002013. Which cell type is enriched for this sp... | non-classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04697","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Human immunodeficiency virus 1 to gastric cancer via a downregulation relationship fo... | |
medium_hidden_intermediate_04699 | Pegivirus C is reported to downregulate a gene that is involved in flagellated sperm motility. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.456 and an adjusted p-value of 0.005788. Which protein is encoded by this specific gene? | Proteasome activator complex subunit 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04699","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in flagellated sperm motility. In a study of peripheral bloo... | |
medium_hidden_intermediate_04700 | A gene is downregulated by Measles morbillivirus and located in the cytoplasm. Experimental evidence for this gene reports a log2 fold change of approximately -2.22 and an adjusted p-value of approximately 0.00027. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04700","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Measles morbillivirus and located in the cytoplasm. Experimental evidence for this gene reports a... | |
medium_hidden_intermediate_04701 | In a study of glioma stem cells (GSE114907), Zika virus infection was found to downregulate a gene that enables endopeptidase activity. One such gene exhibited a log2 fold change of -1.538 and an adjusted p-value of 0.02974. Which protein is encoded by this specific gene? | Insulin-degrading enzyme | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04701","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), Zika virus infection was found to downregulate a gene that enables endopeptidas... | |
medium_hidden_intermediate_04702 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and known to interact with CUL3 exhibits a log2 fold change of 5.681 and an adjusted p-value of 4.295e-07. Which disease is associated with this specific gene? | lipoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04702","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and known to interact with... | |
medium_hidden_intermediate_04703 | Human immunodeficiency virus 1 upregulates a gene that interacts with RPA1. In a study of macrophages (GSE108897), one such gene exhibits a log2 fold change of 1.784 and an adjusted p-value of 7.423e-07. Which protein is encoded by this gene? | Farnesyl pyrophosphate synthase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04703","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that interacts with RPA1. In a study of macrophages (GSE108897), one such ... | |
medium_hidden_intermediate_04704 | Zika virus downregulates a gene that is involved in the positive regulation of TORC1 signaling. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -2.102 and an adjusted p-value of 0.008659. Which protein is encoded by this specific gene? | Ubiquitin carboxyl-terminal hydrolase 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04704","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the positive regulation of TORC1 signaling. In a study of glioma stem ce... | |
medium_hidden_intermediate_04705 | In a study of pleural mesothelioma cells (GSE117668), a gene is upregulated by Measles morbillivirus and interacts with MYC. This specific gene exhibits a log2 fold change of approximately 1.16 and an adjusted p-value of approximately 0.005. Which protein is encoded by this gene? | Ataxin-7-like protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04705","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), a gene is upregulated by Measles morbillivirus and interacts with MYC.... | |
medium_hidden_intermediate_04706 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that subsequently interacts with MAPK9. Experimental data for this gene reports a log2 fold change of -1.311 and an adjusted p-value of 0.03036. Which protein is encoded by this gene? | Dual specificity protein phosphatase 8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04706","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that subsequently interacts with MAPK9. Experimen... | |
medium_hidden_intermediate_04707 | A gene is downregulated by Human betaherpesvirus 5 and located in the endoplasmic reticulum membrane. Experimental data for this gene shows a log2 fold change of -1.239 and an adjusted p-value of 0.003381. Which cell type is this gene enriched in? | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04707","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Human betaherpesvirus 5 and located in the endoplasmic reticulum membrane. Experimental data for ... | |
medium_hidden_intermediate_04708 | Cardiovirus A downregulates a gene that is involved in the negative regulation of protein binding. Experimental data from a cervical adenocarcinoma cell line (study GSE122967) indicates that this gene has a log2 fold change of approximately -1.29 and an adjusted p-value of 0.0134. Which protein is encoded by this gene? | Serine/threonine/tyrosine-interacting protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04708","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A downregulates a gene that is involved in the negative regulation of protein binding. Experimental data from a ... | |
medium_hidden_intermediate_04711 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in Vesicle-mediated transport. One of these genes exhibits a log2 fold change of -1.649 and an adjusted p-value of 0.02589 in lung cells. Which disease is associated with this specific gene? | psoriasis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04711","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in Vesicle-mediated tra... | |
medium_hidden_intermediate_04713 | Severe acute respiratory syndrome-related coronavirus is linked to G alpha (i) signalling events via an intermediate gene that is downregulated by the virus and participates in the signalling pathway. One such intermediate gene exhibits a log2 fold change of -1.050 and an adjusted p-value of 0.04501 in a specific study... | Neuropeptides B/W receptor type 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04713","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus is linked to G alpha (i) signalling events via an intermediate gene th... | |
medium_hidden_intermediate_04715 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the defense response to virus. Experimental data for this gene reports a log2 fold change of approximately 1.15 and an adjusted p-value of 0.006. Which disease is associated with this gene? | spondylitis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04715","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the defense response to vi... | |
medium_hidden_intermediate_04716 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene that participates in the CDC42 GTPase cycle. This specific gene exhibited a log2 fold change of 1.544 and an adjusted p-value of 1.208e-07. Which protein is encoded by this gene? | Inactive Rho GTPase-activating protein 11B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04716","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene that pa... | |
medium_hidden_intermediate_04717 | Hepacivirus C upregulates a gene that participates in protein-protein interactions at synapses. In a study of hepatocytes (GSE132606), one such gene showed a log2 fold change of 1.306 and an adjusted p-value of 0.01557. Which protein is encoded by this gene? | Drebrin-like protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04717","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in protein-protein interactions at synapses. In a study of hepatocytes (G... | |
medium_hidden_intermediate_04718 | Two genes are linked to Human immunodeficiency virus 1 via downregulation and to Barrett esophagus via genomic alterations. One of these genes exhibits a log2 fold change of approximately -1.25 and an adjusted p-value of approximately 0.00065 in macrophages from study GSE108897. Which cellular component is associated w... | mitochondrion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04718","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Human immunodeficiency virus 1 via downregulation and to Barrett esophagus via genomic alterations. ... | |
medium_hidden_intermediate_04719 | ESR1 interacts with a protein that is located in the nucleus. Evidence regarding this protein states: 'In the presence of E2, ERα bound ASC1 and displaced UfSP2, leading to ASC1 ufmylation.' Which gene encodes this protein? | Activating signal cointegrator 1 complex subunit 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04719","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"ESR1 interacts with a protein that is located in the nucleus. Evidence regarding this protein states: 'In the presence of E2... | |
medium_hidden_intermediate_04720 | Measles morbillivirus downregulates a gene that participates in the process where TNFs bind their physiological receptors. Evidence for this gene in pleural mesothelioma cells (study GSE117668) reports a log2 fold change of -3.049 and an adjusted p-value of 0.00992. Which protein is encoded by this gene? | Tumor necrosis factor ligand superfamily member 18 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04720","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus downregulates a gene that participates in the process where TNFs bind their physiological receptors. E... | |
medium_hidden_intermediate_04721 | A gene is upregulated by Measles morbillivirus and participates in the Immune System. Evidence for this gene reports a log2 fold change of approximately 1.205 and an adjusted p-value of 0.01039. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04721","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and participates in the Immune System. Evidence for this gene reports a log2 ... | |
medium_hidden_intermediate_04722 | Zika virus downregulates a specific gene that enables DNA binding. Experimental data for this gene in glioma stem cells (study GSE114907) shows a log2 fold change of -2.653 and an adjusted p-value of 0.007522. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04722","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that enables DNA binding. Experimental data for this gene in glioma stem cells (stu... | |
medium_hidden_intermediate_04723 | Pegivirus C is reported to downregulate a gene that is located in the mitochondrial inner membrane. Evidence for one such gene shows a log2 fold change of -1.901 and an adjusted p-value of 0.008122. Which disease is associated with this gene as a biomarker? | nervous system disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04723","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is located in the mitochondrial inner membrane. Evidence for one such ge... | |
medium_hidden_intermediate_04724 | Two genes are upregulated by Human immunodeficiency virus 1 and located in membrane rafts. One of these genes exhibits a log2 fold change of 1.623 and an adjusted p-value of 0.006967 in macrophages (study GSE108897). Which disease is associated with this specific gene? | open-angle glaucoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04724","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and located in membrane rafts. One of these genes exhibits a log... | |
medium_hidden_intermediate_04725 | Human immunodeficiency virus 1 downregulates a gene that participates in chromatin organization. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of -1.130 and an adjusted p-value of 0.04213. Which cellular component is this gene located in? | SAGA-type complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04725","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in chromatin organization. In a study of macrophages (... | |
medium_hidden_intermediate_04729 | Zika virus upregulates a gene that is located in the plasma membrane. Evidence for this gene in neural stem cells (study GSE129180) reports a log2 fold change of approximately 3.87 and an adjusted p-value of approximately 0.025. Which disease is associated with this gene as a biomarker? | hyperlipidemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04729","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that is located in the plasma membrane. Evidence for this gene in neural stem cells (study GSE... | |
medium_hidden_intermediate_04730 | A gene is upregulated by Hepacivirus C and is involved in erythrocyte differentiation. Experimental data for this gene reports a log2 fold change of approximately 1.785 and an adjusted p-value of approximately 0.027. Which disease is associated with this gene as a biomarker? | rheumatoid arthritis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04730","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Hepacivirus C and is involved in erythrocyte differentiation. Experimental data for this gene repor... | |
medium_hidden_intermediate_04731 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in the RAC1 GTPase cycle. Evidence for this gene reports a log2 fold change of -1.349 and an adjusted p-value of 0.009671. Which protein is encoded by this gene? | FERM, ARHGEF and pleckstrin domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04731","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in the RAC1 GTPase cycle. Evide... | |
medium_hidden_intermediate_04734 | A gene is upregulated by Hepacivirus C and participates in Signaling by Rho GTPases. Experimental evidence for this gene reports a log2 fold change of 1.862 and an adjusted p-value of 0.03341. Which disease is associated with this gene through genomic alterations? | glioma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04734","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Hepacivirus C and participates in Signaling by Rho GTPases. Experimental evidence for this gene rep... | |
medium_hidden_intermediate_04736 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the upregulation of specific genes that participate in developmental biology. One such gene exhibits a log2 fold change of approximately 1.267 and an adjusted p-value of 0.01515. Which protein is encoded by this specific gene... | Cornifin-B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04736","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the upregulation of specific ... | |
medium_hidden_intermediate_04737 | In a study of tracheobronchial epithelial cells (GSE102392), a specific histone variant is downregulated by Primate bocaparvovirus 1 and participates in HCMV Early Events. This entity exhibits a log2 fold change of -1.108 and an adjusted p-value of 0.01796. Which protein is encoded by this specific histone variant? | Histone H4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04737","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of tracheobronchial epithelial cells (GSE102392), a specific histone variant is downregulated by Primate bocaparv... | |
medium_hidden_intermediate_04738 | In a study of macrophages (GSE108897), a gene is identified that is upregulated by Human immunodeficiency virus 1 and participates in Diseases of metabolism. This specific gene exhibits a log2 fold change of approximately 1.29 and an adjusted p-value of approximately 0.027. Which protein is encoded by this gene? | Syndecan-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04738","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is upregulated by Human immunodeficiency virus 1 and partic... | |
medium_hidden_intermediate_04743 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to NR1H2 and NR1H3-mediated signaling via a 'participates in' relationship. One of these genes has an associated expression profile showing a log2 fold change of -1.795 and an adjusted p-val... | Endonuclease/exonuclease/phosphatase family domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04743","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_04744 | Demeclocycline interacts with multiple agents that also interact with Sodium citrate. One such agent is associated with evidence stating that the presence of sodium citrate leads to the fastest degradation. Which disease is this agent indicated for? | iron deficiency anemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04744","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Demeclocycline interacts with multiple agents that also interact with Sodium citrate. One such agent is associated with evid... | |
medium_hidden_intermediate_04746 | Zika virus downregulates a specific gene that participates in the cellular response to chemical stress. Evidence for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.33 and an adjusted p-value of 0.0165. Which disease is associated with this gene as a biomarker? | essential hypertension | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04746","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in the cellular response to chemical stress. Evidence for this ge... | |
medium_hidden_intermediate_04750 | Two genes are structurally linked to Pegivirus C via a downregulation relationship and to the positive regulation of cell migration via an involvement relationship. One of these genes has a reported log2 fold change of -1.228 and an adjusted p-value of 0.005723 in peripheral blood mononuclear cells. Which disease is as... | adenoviridae infectious disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04750","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Pegivirus C via a downregulation relationship and to the positive regulation of cell mi... | |
medium_hidden_intermediate_04751 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate specific genes that participate in the metabolism of steroid hormones. One such gene exhibited a log2 fold change of approximately 2.195 and an adjusted p-value of 3.876e-07. Which biological process is this sp... | sex determination | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04751","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate specific genes... | |
medium_hidden_intermediate_04752 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of a specific gene, which in turn interacts with the histone variant H3F3A. One such gene exhibits a log2 fold change of 1.095 and an adjusted p-value of 0.007312. Which protein is encoded by this gene? | Ubinuclein-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04752","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of a specific gene, whic... | |
medium_hidden_intermediate_04753 | A gene is upregulated by Primate bocaparvovirus 1 and participates in the Adaptive Immune System. Transcriptomic evidence for this gene shows a log2 fold change of 1.676 and an adjusted p-value of 0.01636. Which protein is encoded by this gene? | Killer cell lectin-like receptor subfamily G member 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04753","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and participates in the Adaptive Immune System. Transcriptomic evidence fo... | |
medium_hidden_intermediate_04754 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a gene involved in lipid metabolic process. One such gene exhibited a log2 fold change of approximately -1.043 and an adjusted p-value of 0.009523. Which protein is encoded by this specific gene? | Platelet-activating factor acetylhydrolase IB subunit alpha2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04754","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a gene invol... | |
medium_hidden_intermediate_04755 | Pegivirus C is reported to downregulate a gene that serves as a biomarker for glioblastoma. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibits a log2 fold change of -1.228 and an adjusted p-value of 0.02459. Which protein is encoded by this specific gene? | Single-stranded DNA-binding protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04755","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that serves as a biomarker for glioblastoma. In a study of peripheral blood m... | |
medium_hidden_intermediate_04757 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes that participate in organelle biogenesis and maintenance. One such gene exhibited a log2 fold change of 2.996 and an adjusted p-value of 2.814e-08. What molecular function is enabled by this speci... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04757","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes ... | |
medium_hidden_intermediate_04758 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in ribosomal large subunit biogenesis. Evidence for one such gene reports a log2 fold change of 1.440 and an adjusted p-value of 0.03711. Which protein is encoded by that gene? | Ribosome biogenesis protein WDR12 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04758","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in ribosomal large subunit biogene... | |
medium_hidden_intermediate_04761 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 downregulates a gene that participates in the RHO GTPase cycle. One such gene exhibits a log2 fold change of -1.322 and an adjusted p-value of 0.0002311. Which protein is encoded by this specific gene? | N-chimaerin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04761","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 downregulates a gene that participates in the RHO GTPa... | |
medium_hidden_intermediate_04762 | Pegivirus C is reported to downregulate a specific gene, which in turn enables heat shock protein binding. Experimental data for this gene in peripheral blood mononuclear cells (from study GSE131504) show a log2 fold change of -1.346 and an adjusted p-value of 0.003082. Which protein is encoded by this gene? | Methyltransferase-like protein 22 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04762","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn enables heat shock protein binding. Experimental data... | |
medium_hidden_intermediate_04763 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are located in the microtubule cytoskeleton. One of these genes exhibits a log2 fold change of -1.235 and an adjusted p-value of 0.0161 in a specific study. Which cell type is enriched for this specific gene? | classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04763","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are located in the microtubule cyto... | |
medium_hidden_intermediate_04764 | Two genes are upregulated by Human immunodeficiency virus 1 and are associated with malignant colon neoplasm through genomic alterations. One of these genes exhibits a log2 fold change of 2.333 and an adjusted p-value of 0.004278 in macrophages (study GSE108897). Which disease is linked to this specific gene via a biom... | autism spectrum disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04764","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and are associated with malignant colon neoplasm through genomic... | |
medium_hidden_intermediate_04765 | Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' interaction and to RBPJ via a 'binds' interaction. One of these genes exhibits a log2 fold change of -2.574 and an adjusted p-value of 0.04663 in macrophages (study GSE108897). Which disease is associated with this specific gene? | glioma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04765","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' interaction and to RBPJ via a 'bin... | |
medium_hidden_intermediate_04766 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are genetically associated with diabetes mellitus. One of these genes shows a log2 fold change of approximately 1.183 and an adjusted p-value of 2.775e-06 in a specific study. Which protein is encoded by this gene? | Transducin beta-like protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04766","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are genetically associated with diabe... | |
medium_hidden_intermediate_04769 | Human betaherpesvirus 5 is known to downregulate a specific gene that participates in the metabolism of lipids. Experimental data for this gene in foreskin fibroblast cell lines reports a log2 fold change of approximately -3.01 and an adjusted p-value of 0.0012. Which molecular function is enabled by this gene? | arylsulfatase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04769","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is known to downregulate a specific gene that participates in the metabolism of lipids. Experimental... | |
medium_hidden_intermediate_04770 | BMP4 is involved in multiple biological processes that are part of lung development. One such process is supported by evidence stating: 'Our findings support a critical role for BMPs in lung vasculogenesis.' Which biological process is this entity a subclass of (is_a)? | vasculature development | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04770","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"BMP4 is involved in multiple biological processes that are part of lung development. One such process is supported by eviden... | |
medium_hidden_intermediate_04771 | Pegivirus C is associated with the downregulation of a specific gene, which in turn enables enzyme binding. Experimental data from a study on peripheral blood mononuclear cells (GSE131504) indicates that this gene has a log2 fold change of approximately -2.067 and an adjusted p-value of 0.006589. Which protein is encod... | NEDD4-binding protein 2-like 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04771","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is associated with the downregulation of a specific gene, which in turn enables enzyme binding. Experimental dat... |
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