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medium_hidden_intermediate_04772 | Two genes are upregulated by Human immunodeficiency virus 1 and participate in collagen degradation. One of these genes exhibits a log2 fold change of 2.784 and an adjusted p-value of 0.001801 in macrophages (study GSE108897). Which disease is associated with this specific gene as a biomarker? | central serous chorioretinopathy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04772","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and participate in collagen degradation. One of these genes exhi... | |
medium_hidden_intermediate_04774 | In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upregulate a specific gene, which in turn interacts with TP53. Evidence for this intermediate gene reports a log2 fold change of 1.065 and an adjusted p-value of 0.01662. Which protein is encoded by th... | Zinc finger protein 420 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04774","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upreg... | |
medium_hidden_intermediate_04775 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the RAC1 GTPase cycle. One of these genes shows a log2 fold change of approximately 1.049 and an adjusted p-value of 0.0008212 in lung cells. Which protein interacts with this specific gene product? | NCK2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04775","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the RAC1 GTPase cycle.... | |
medium_hidden_intermediate_04777 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in the regulation of transcription by RNA polymerase II. Experimental data for this gene in lung cells shows a log2 fold change of approximately -1.586 and an adjusted p-value of 0.0001465. Which gene interacts with this downreg... | DDIT3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04777","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in the regulation of transcripti... | |
medium_hidden_intermediate_04778 | Two genes are each upregulated by Influenza A virus and associated with breast carcinoma. One of these genes exhibits a log2 fold change of approximately 1.375 and an adjusted p-value of 0.003156 in a specific study. Which cell type is enriched for this specific gene? | naive B cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04778","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each upregulated by Influenza A virus and associated with breast carcinoma. One of these genes exhibits a log2... | |
medium_hidden_intermediate_04780 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a gene involved in the phosphatidylinositol phosphate biosynthetic process. This specific gene exhibited a log2 fold change of 1.573 and an adjusted p-value of 0.0002262. Which protein is encoded by this gene? | Inositol-trisphosphate 3-kinase B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04780","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a gene involved in the pho... | |
medium_hidden_intermediate_04782 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and to Post-translational protein phosphorylation via a 'participates in' relationship. One of these genes is associated with experimental data showing a log2 fold change of approximately 1.27 an... | Protein eva-1 homolog A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04782","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship... | |
medium_hidden_intermediate_04784 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is located in the centriole. Evidence for one such gene reports a log2 fold change of -1.258 and an adjusted p-value of 0.007462. Which protein is encoded by that gene? | Ciliogenesis and planar polarity effector 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04784","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is located in the centriole. Evidence for on... | |
medium_hidden_intermediate_04785 | Human immunodeficiency virus 1 upregulates a gene that participates in the Adaptive Immune System. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of 1.179 and an adjusted p-value of 0.01381. Which disease is associated with this gene? | cervical cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04785","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in the Adaptive Immune System. Evidence for this gene in... | |
medium_hidden_intermediate_04787 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are located in the lysosomal membrane. One of these genes exhibits a log2 fold change of 1.283 and an adjusted p-value of 0.0002832 in response to the virus. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04787","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are located in the lysosomal membrane... | |
medium_hidden_intermediate_04788 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE148697), a specific gene is downregulated by the virus and is involved in the positive regulation of osteoblast differentiation. This gene exhibits a log2 fold change of -1.933 and an adjusted p-value of 8.392e-05. Which pr... | Low-density lipoprotein receptor-related protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04788","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE148697), a specific gene is... | |
medium_hidden_intermediate_04789 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with PTEN. One of these genes exhibits a log2 fold change of 1.193 and an adjusted p-value of 0.007355 in response to the virus. Which cellular component is this specific gene located in? | membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04789","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with PTEN. One of these gene... | |
medium_hidden_intermediate_04790 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in odontogenesis. Evidence for this gene reports a log2 fold change of 1.014 and an adjusted p-value of 0.004393. Which protein is encoded by this gene? | Tuftelin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04790","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in odontogenesis. Evidence for thi... | |
medium_hidden_intermediate_04792 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in aerobic respiration and respiratory electron transport. Evidence for this gene reports a log2 fold change of -1.287 and an adjusted p-value of 0.002482. Which protein is encoded by this gene? | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04792","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in aerobic respiration and resp... | |
medium_hidden_intermediate_04793 | Zika virus downregulates a gene that participates in ion channel transport. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -2.245 and an adjusted p-value of 0.01161. Which protein is encoded by this specific gene? | Endoplasmic reticulum transmembrane helix translocase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04793","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in ion channel transport. In a study of glioma stem cells (GSE114907), one... | |
medium_hidden_intermediate_04794 | Pegivirus C is reported to downregulate a specific gene, which in turn encodes a protein located in the axoneme. In a study of peripheral blood mononuclear cells (GSE131504), this gene exhibited a log2 fold change of approximately -1.03 and an adjusted p-value of 0.0037. What molecular function is enabled by the protei... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04794","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn encodes a protein located in the axoneme. In a study ... | |
medium_hidden_intermediate_04795 | Two genes are structurally linked to Cardiovirus A via a 'downregulates' relationship and to potassium channel regulator activity via an 'enables' relationship. One of these genes has a reported log2 fold change of -1.122 and an adjusted p-value of 0.01929 in a specific study. Which disease is associated with this spec... | glioblastoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04795","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Cardiovirus A via a 'downregulates' relationship and to potassium channel regulator act... | |
medium_hidden_intermediate_04796 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and binds to TUBB4A. This specific gene exhibits a log2 fold change of 1.123 and an adjusted p-value of 2.57e-05. Which protein is encoded by this gene? | Prefoldin subunit 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04796","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and binds to TUBB4A. Th... | |
medium_hidden_intermediate_04797 | A gene is upregulated by Measles morbillivirus and serves as a biomarker for pediatric osteosarcoma. Evidence for this gene reports a log2 fold change of 1.712 and an adjusted p-value of 0.01975. Which protein is encoded by this gene? | Iroquois-class homeodomain protein IRX-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04797","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and serves as a biomarker for pediatric osteosarcoma. Evidence for this gene ... | |
medium_hidden_intermediate_04801 | Two genes are upregulated by Human alphaherpesvirus 3 and are enriched in eosinophils. One of these genes exhibits a log2 fold change of 1.927 and an adjusted p-value of 8.228e-07 in a melanoma cell line study (GSE136586). Which cellular component is the location of this specific gene? | endoplasmic reticulum | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04801","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human alphaherpesvirus 3 and are enriched in eosinophils. One of these genes exhibits a log2 fo... | |
medium_hidden_intermediate_04808 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that enables retinoid binding. Evidence for one such gene reports a log2 fold change of -2.179 and an adjusted p-value of 0.02243. Which protein is encoded by that gene? | Retinol-binding protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04808","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that enables retinoid binding. Evidence for one s... | |
medium_hidden_intermediate_04810 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, which in turn interacts with the HTT protein. This gene exhibited a log2 fold change of approximately 1.271 and an adjusted p-value of 4.645e-09. What is the name of the protein encoded by this... | Pre-mRNA-processing factor 40 homolog B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04810","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_04812 | Zika virus downregulates a specific gene, which in turn interacts with VAPA. Experimental data for this gene in glioma stem cells (study GSE114907) show a log2 fold change of -3.416 and an adjusted p-value of 0.001865. Which biological process is this gene involved in? | intracellular signal transduction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04812","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with VAPA. Experimental data for this gene in glioma stem ... | |
medium_hidden_intermediate_04813 | Two genes are upregulated by Vaccinia virus and both enable protein homodimerization activity. One of these genes exhibits a log2 fold change of 2.217 and an adjusted p-value of 3.184e-09 in cervical adenocarcinoma cell lines. Which disease is associated with genomic alterations in this specific gene? | oropharynx cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04813","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and both enable protein homodimerization activity. One of these genes exhibits a... | |
medium_hidden_intermediate_04817 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene was found to be downregulated by the virus and is known to enable small GTPase binding. This gene exhibited a log2 fold change of -1.126 and an adjusted p-value of 0.01796. Which protein does this gene interact... | RHOQ | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04817","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene was found to b... | |
medium_hidden_intermediate_04819 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Diseases of metabolism. Experimental evidence for this gene reports a log2 fold change of approximately 1.045 and an adjusted p-value of 0.001447. Which protein does this gene interact with? | SQSTM1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04819","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Diseases of metabolism. E... | |
medium_hidden_intermediate_04820 | Zaire ebolavirus infection leads to the upregulation of genes involved in the antimicrobial humoral immune response mediated by antimicrobial peptides. In a study of retinal pigment epithelium cells (GSE100839), one such upregulated gene exhibited a log2 fold change of 8.062 and an adjusted p-value of 1.19e-07. Which p... | C-X-C motif chemokine 11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04820","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus infection leads to the upregulation of genes involved in the antimicrobial humoral immune response mediated... | |
medium_hidden_intermediate_04821 | Hepacivirus C is associated with the downregulation of a gene that is involved in the negative regulation of transcription by RNA polymerase II. Experimental data for this gene reports a log2 fold change of approximately -1.55 and an adjusted p-value of 0.0021. Which protein is encoded by this gene? | Zinc finger protein 345 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04821","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is associated with the downregulation of a gene that is involved in the negative regulation of transcription b... | |
medium_hidden_intermediate_04822 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to upregulate a specific gene that participates in cytokine signaling in the immune system. This gene exhibited a log2 fold change of approximately 2.63 and an adjusted p-value of 0.0319. Which protein is encoded by this gen... | Interleukin-36 gamma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04822","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_04823 | Zika virus downregulates a gene that is located in the nucleoplasm. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of approximately -1.80 and an adjusted p-value of 0.0142. Which protein is encoded by this specific gene? | Histone H4 transcription factor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04823","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in the nucleoplasm. In a study of glioma stem cells (GSE114907), one such ge... | |
medium_hidden_intermediate_04824 | Human betaherpesvirus 5 is known to downregulate a specific gene that participates in the metabolism of proteins. Transcriptomic data from a study (GSE130665) on foreskin fibroblast cell lines indicates that this gene exhibits a log2 fold change of -1.342 and an adjusted p-value of 2.074e-10. Which cell type is this ge... | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04824","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is known to downregulate a specific gene that participates in the metabolism of proteins. Transcript... | |
medium_hidden_intermediate_04827 | Pegivirus C is reported to downregulate a gene that is located in the lysosomal membrane. Experimental data for this gene in peripheral blood mononuclear cells (study GSE131504) show a log2 fold change of approximately -1.94 and an adjusted p-value of 0.016. Which biological process is this gene involved in? | cell volume homeostasis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04827","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is located in the lysosomal membrane. Experimental data for this gene in... | |
medium_hidden_intermediate_04828 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and its encoded protein is located in the apical plasma membrane. Experimental data for this gene shows a log2 fold change of approximately 7.93 and an adjusted p-value of approximately 0.010. Which protein is encoded by this gene? | Mucin-13 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04828","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and its encoded protein is located in the api... | |
medium_hidden_intermediate_04829 | Measles morbillivirus upregulates a gene that interacts with STK4. One such gene exhibits a log2 fold change of 1.028 and an adjusted p-value of 0.01177 in study GSE131840. Which protein is encoded by this gene? | Serine/threonine-protein kinase MARK2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04829","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that interacts with STK4. One such gene exhibits a log2 fold change of 1.028 and an... | |
medium_hidden_intermediate_04830 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the metabolism of folate and pterines. Evidence for this specific gene reports a log2 fold change of 1.188 and an adjusted p-value of 0.008861. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04830","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the metabolism of folate and p... | |
medium_hidden_intermediate_04831 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and known to interact with AGR2 exhibits a log2 fold change of approximately 2.175 and an adjusted p-value of 2.977e-10. Which biological process is this specific gene involved in? | protein folding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04831","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and known to interact with... | |
medium_hidden_intermediate_04832 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is enriched in Gamma delta(γδ) T cells. Evidence for this gene reports a log2 fold change of -1.966 and an adjusted p-value of 0.03249. Which protein is encoded by this gene? | GDP-fucose protein O-fucosyltransferase 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04832","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is enriched in Gamma delta(γδ) T cells.... | |
medium_hidden_intermediate_04834 | Pegivirus C is reported to downregulate a specific gene, which in turn interacts with SHARPIN. Experimental data for this gene in peripheral blood mononuclear cells (from study GSE131504) indicates a log2 fold change of -1.225 and an adjusted p-value of 0.00376. Which protein is encoded by this gene? | Golgi to ER traffic protein 4 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04834","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn interacts with SHARPIN. Experimental data for this ge... | |
medium_hidden_intermediate_04835 | In a study of bronchial epithelial cells infected with Influenza A virus (GSE147507), a specific gene is upregulated and involved in the positive regulation of calcium ion import. This gene exhibits a log2 fold change of approximately 2.56 and an adjusted p-value of approximately 0.00036. Which protein is encoded by th... | Stromal cell-derived factor 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04835","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of bronchial epithelial cells infected with Influenza A virus (GSE147507), a specific gene is upregulated and inv... | |
medium_hidden_intermediate_04836 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of a gene product that is located in the cytosol. One such entity exhibits a log2 fold change of approximately 1.384 and an adjusted p-value of 0.01075. Which protein is encoded by this specific gene entity? | Mitochondrial tRNA methylthiotransferase CDK5RAP1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04836","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of a gene product that i... | |
medium_hidden_intermediate_04837 | Hepacivirus C upregulates a gene that participates in Signaling by Rho GTPases. Evidence for this gene in hepatocytes (study GSE132606) reports a log2 fold change of approximately 2.08 and an adjusted p-value of 1.50e-07. Which cellular component is this gene located in? | lamellipodium | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04837","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in Signaling by Rho GTPases. Evidence for this gene in hepatocytes (study... | |
medium_hidden_intermediate_04839 | Ileitis is localized to an anatomical structure that is classified as an organ. Evidence regarding one such structure cites 'External genital organs of the female mammal'. Which anatomical structure is connected to that entity via a 'part of' relationship? | external female genitalia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04839","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Ileitis is localized to an anatomical structure that is classified as an organ. Evidence regarding one such structure cites ... | |
medium_hidden_intermediate_04840 | Zika virus downregulates a gene that is involved in the negative regulation of organ growth. Experimental data from glioma stem cells (study GSE114907) indicates that this specific gene has a log2 fold change of -1.411 and an adjusted p-value of 0.01386. Which protein is encoded by this gene? | Protein WWC3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04840","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the negative regulation of organ growth. Experimental data from glioma s... | |
medium_hidden_intermediate_04841 | Human immunodeficiency virus 1 upregulates a gene that is associated with leukemia. Evidence for this gene in natural killer cells from study GSE125686 reports a log2 fold change of approximately 1.036 and an adjusted p-value of 0.03042. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04841","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is associated with leukemia. Evidence for this gene in natural killer... | |
medium_hidden_intermediate_04842 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Signaling by NOTCH. Evidence for this gene reports a log2 fold change of -1.306 and an adjusted p-value of 0.002968. Which cell type is this gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04842","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Signaling by NOTCH. Evi... | |
medium_hidden_intermediate_04845 | Pegivirus C downregulates a gene that is involved in the DNA damage response. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -2.585 and an adjusted p-value of 0.003798. Which protein is encoded by this specific gene? | Zinc finger and BTB domain-containing protein 40 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04845","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that is involved in the DNA damage response. In a study of peripheral blood mononuclear cel... | |
medium_hidden_intermediate_04847 | Human immunodeficiency virus 1 downregulates a gene that participates in macroautophagy. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of approximately -1.06 and an adjusted p-value of 0.019. Which disease is associated with this gene? | breast carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04847","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in macroautophagy. Evidence for this gene in macrophag... | |
medium_hidden_intermediate_04848 | Hepacivirus C upregulates a specific gene that participates in Gene expression (Transcription). Evidence for this gene reports a log2 fold change of 1.991 and an adjusted p-value of 0.03779. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04848","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a specific gene that participates in Gene expression (Transcription). Evidence for this gene repor... | |
medium_hidden_intermediate_04849 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Homologous Recombination (HRR) leading to HDR. One of these genes shows a log2 fold change of 1.686 and an adjusted p-value of 0.0424 in a specific study. Which disease is associated with this gene as a biomarker? | fibrosarcoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04849","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Homologous Recombinati... | |
medium_hidden_intermediate_04850 | Two genes are upregulated by Vaccinia virus and interact with HIST1H4A. One of these genes shows a log2 fold change of 3.195 and an adjusted p-value of 9.151e-10 in cervical adenocarcinoma cell lines. Which disease is associated with this specific gene as a biomarker? | kidney neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04850","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and interact with HIST1H4A. One of these genes shows a log2 fold change of 3.195... | |
medium_hidden_intermediate_04852 | Rhinovirus A infection is associated with the upregulation of genes located in the sperm flagellum. One such gene exhibits a log2 fold change of approximately 1.39 and an adjusted p-value of 0.0121 in cytotoxic T-lymphocytes. Which protein does this specific gene product interact with? | KRT38 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04852","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection is associated with the upregulation of genes located in the sperm flagellum. One such gene exhibits a... | |
medium_hidden_intermediate_04853 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that subsequently binds to YWHAZ. Experimental data for one such gene reports a log2 fold change of -1.063 and an adjusted p-value of 9.363e-05. Which protein is encoded by this gene? | TBC1 domain family member 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04853","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that subsequently binds to YWHAZ. Experimental da... | |
medium_hidden_intermediate_04855 | Pegivirus C is reported to downregulate a specific gene, which in turn interacts with TP53. Experimental data for this intermediate gene shows a log2 fold change of approximately -1.27 and an adjusted p-value of 0.019. In which cell type is this gene reported to be enriched? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04855","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn interacts with TP53. Experimental data for this inter... | |
medium_hidden_intermediate_04856 | A gene is downregulated by Primate bocaparvovirus 1 and is enriched in Gamma delta (γδ) T cells. Experimental evidence for this gene reports a log2 fold change of -2.011 and an adjusted p-value of 0.00878. Which molecular function is enabled by this gene? | endopeptidase inhibitor activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04856","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and is enriched in Gamma delta (γδ) T cells. Experimental evidence for t... | |
medium_hidden_intermediate_04857 | FLNA interacts with a protein that enables protein binding. Evidence indicates that while KCNQ1 channels associated with KCNE1 or KCNE2 target lipid rafts, KCNQ1 associated with KCNE3-5 does not. Which protein, encoded by the gene corresponding to this entity, is the subject of this evidence? | Potassium voltage-gated channel subfamily E member 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04857","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"FLNA interacts with a protein that enables protein binding. Evidence indicates that while KCNQ1 channels associated with KCN... | |
medium_hidden_intermediate_04858 | Measles morbillivirus upregulates a gene that participates in factors involved in megakaryocyte development and platelet production. Evidence for one such gene reports a log2 fold change of 2.086 and an adjusted p-value of 1.841e-05. Which disease is associated with that gene as a biomarker? | adenoviridae infectious disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04858","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that participates in factors involved in megakaryocyte development and platelet pro... | |
medium_hidden_intermediate_04859 | Measles morbillivirus upregulates a gene that interacts with YWHAB. Evidence for one such gene reports a log2 fold change of 1.133 and an adjusted p-value of 0.02885. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04859","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that interacts with YWHAB. Evidence for one such gene reports a log2 fold change of... | |
medium_hidden_intermediate_04860 | Two genes are structurally linked to Measles morbillivirus via a 'downregulates' relationship and to classical monocytes via an 'enriched in' relationship. One of these genes is associated with experimental data showing a log2 fold change of approximately -1.109 and an adjusted p-value of 0.01532. Which protein is enco... | Probable G-protein coupled receptor 141 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04860","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Measles morbillivirus via a 'downregulates' relationship and to classical monocytes via... | |
medium_hidden_intermediate_04861 | Two genes are structurally linked to Pegivirus C via downregulation and to RBX1 via binding. One of these genes exhibits a log2 fold change of -2.358 and an adjusted p-value of 0.0001203 in peripheral blood mononuclear cells. Which disease is associated with this specific gene? | Tayoun-Maawali syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04861","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Pegivirus C via downregulation and to RBX1 via binding. One of these genes exhibits a l... | |
medium_hidden_intermediate_04862 | A gene serves as a marker for Sertoli cells and is enriched in neutrophils. Evidence for this gene includes a mean expression of 312.73 TPM, a z-score of 3.18, and a fold enrichment of 18.84. Which gene interacts with the gene identified by these expression statistics? | SLC18A3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04862","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for Sertoli cells and is enriched in neutrophils. Evidence for this gene includes a mean expressio... | |
medium_hidden_intermediate_04865 | Zika virus downregulates a specific gene, which in turn interacts with CCNF. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.056 and an adjusted p-value of 0.03339. Which biological process is this gene involved in? | response to unfolded protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04865","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with CCNF. Experimental data for this gene in glioma stem ... | |
medium_hidden_intermediate_04866 | Hepacivirus C upregulates a gene that participates in TCF-dependent signaling in response to WNT. In a study of hepatocytes (GSE132606), one such gene showed a log2 fold change of 3.225 and an adjusted p-value of 0.002779. Which protein does this specific gene product bind to? | LRP6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04866","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in TCF-dependent signaling in response to WNT. In a study of hepatocytes ... | |
medium_hidden_intermediate_04867 | Two genes are structurally linked from Severe acute respiratory syndrome-related coronavirus via a downregulation relationship and onward to endometriosis via an association relationship. One of these genes has been reported in a study with a log2 fold change of -2.348 and an adjusted p-value of 0.004589. Which disease... | lung carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04867","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Severe acute respiratory syndrome-related coronavirus via a downregulation relationsh... | |
medium_hidden_intermediate_04868 | In a study of bronchial epithelial cells, a gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the function of Presynaptic nicotinic acetylcholine receptors. This specific gene exhibits a log2 fold change of 1.765 and an adjusted p-value of 0.001669. Which protein is encode... | Neuronal acetylcholine receptor subunit alpha-6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04868","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of bronchial epithelial cells, a gene is upregulated by Severe acute respiratory syndrome-related coronavirus and... | |
medium_hidden_intermediate_04869 | Human alphaherpesvirus 1 upregulates a gene that is associated with leukemia. Evidence for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of 1.632 and an adjusted p-value of 0.03816. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04869","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that is associated with leukemia. Evidence for this gene in a monocytic leukemia... | |
medium_hidden_intermediate_04871 | Two genes are upregulated by Human immunodeficiency virus 1 and participate in the process 'IRE1alpha activates chaperones'. One of these genes exhibits a log2 fold change of 1.061 and an adjusted p-value of 0.01668 in macrophages (study GSE108897). Which disease is associated with this specific gene as a biomarker? | narcolepsy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04871","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and participate in the process 'IRE1alpha activates chaperones'.... | |
medium_hidden_intermediate_04872 | Two genes are upregulated by Human immunodeficiency virus 1 and associated with atherosclerosis. One of these genes exhibits a log2 fold change of approximately 2.10 and an adjusted p-value of 0.001624 in macrophages. Which cellular component is the location of this specific gene? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04872","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and associated with atherosclerosis. One of these genes exhibits... | |
medium_hidden_intermediate_04873 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Class I MHC mediated antigen processing & presentation. Evidence for this gene reports a log2 fold change of 1.085 and an adjusted p-value of 0.01425. Which disease is associated with this gene? | benign neoplasm of large intestine | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04873","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Class I MHC mediated anti... | |
medium_hidden_intermediate_04874 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Glycosphingolipid biosynthesis. Evidence for one such gene reports a log2 fold change of 1.470 and an adjusted p-value of 0.0189. Which protein is encoded by that gene? | Galactoside alpha-(1,2)-fucosyltransferase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04874","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Glycosphingolipid biosynthesis... | |
medium_hidden_intermediate_04876 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the positive regulation of DNA-templated transcription. Experimental data for this gene reports a log2 fold change of -1.296 and an adjusted p-value of 0.0006488. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04876","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the positive regulation ... | |
medium_hidden_intermediate_04877 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a specific gene, which in turn binds to RBBP4. This gene exhibits a log2 fold change of approximately 4.055 and an adjusted p-value of 0.01065. Which protein is encoded by this gene? | Transcription factor E2F2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04877","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a specific gene, which in turn binds... | |
medium_hidden_intermediate_04878 | Vaccinia virus downregulates a gene that participates in lipid metabolism. In a study of cervical adenocarcinoma cell lines (GSE11238), one such gene exhibits a log2 fold change of -1.267 and an adjusted p-value of 0.006449. Which protein is encoded by this specific gene? | Isopentenyl-diphosphate Delta-isomerase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04878","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus downregulates a gene that participates in lipid metabolism. In a study of cervical adenocarcinoma cell lines ... | |
medium_hidden_intermediate_04879 | Measles morbillivirus upregulates a gene that is located in the cytosol. Evidence for one such gene reports a log2 fold change of 1.210 and an adjusted p-value of 0.03531. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04879","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is located in the cytosol. Evidence for one such gene reports a log2 fold chan... | |
medium_hidden_intermediate_04880 | Hepacivirus C is reported to downregulate a gene that enables serine-type peptidase activity. In a specific study, this gene exhibited a log2 fold change of approximately -2.06 and an adjusted p-value of 0.0065. Which protein is encoded by this gene? | Testisin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04880","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that enables serine-type peptidase activity. In a specific study, this gene... | |
medium_hidden_intermediate_04883 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the downregulation of specific genes that participate in immune system processes. One such gene exhibits a log2 fold change of approximately -3.50 and an adjusted p-value of 0.0172. Which cellular compartment is this specific gene... | endoplasmic reticulum-Golgi intermediate compartment | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04883","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the downregulation of specific gen... | |
medium_hidden_intermediate_04884 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene that participates in the integration of energy metabolism. This gene exhibited a log2 fold change of 1.349 and an adjusted p-value of 2.487e-05. Which protein is encoded by this gene? | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04884","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_04885 | Zika virus downregulates a gene that participates in tRNA modification in the nucleus and cytosol. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -2.090 and an adjusted p-value of 0.006143. Which protein is encoded by this specific gene? | Bifunctional glutamate/proline--tRNA ligase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04885","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in tRNA modification in the nucleus and cytosol. In a study of glioma stem... | |
medium_hidden_intermediate_04887 | In a study of Measles morbillivirus infection, a specific gene is downregulated by the virus and its expression is enriched in naive CD4+ T cells. Evidence for this gene reports a log2 fold change of -1.247 and an adjusted p-value of 0.01566. Which protein is encoded by this gene? | Leucine-rich repeat neuronal protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04887","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is downregulated by the virus and its expression is enriched ... | |
medium_hidden_intermediate_04889 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene, which in turn enables transmembrane transporter binding. This gene exhibited a log2 fold change of 3.290 and an adjusted p-value of 0.007815. Which protein is encoded by this gene? | Serine/threonine-protein kinase WNK3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04889","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene, which in ... | |
medium_hidden_intermediate_04890 | In a study of Measles morbillivirus infection, a specific gene is downregulated by the virus and its product is located in the Golgi apparatus. Evidence for this gene reports a log2 fold change of -1.128 and an adjusted p-value of 0.03561. Which protein is encoded by this gene? | Lysosomal enzyme trafficking factor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04890","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is downregulated by the virus and its product is located in t... | |
medium_hidden_intermediate_04891 | In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and participates in the maturation of spike protein. This specific gene exhibits a log2 fold change of -1.495 and an adjusted p-value of 0.005433. Which protein is encoded by this gene? | Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04891","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and part... | |
medium_hidden_intermediate_04892 | Two genes are structurally linked to Cardiovirus A via a 'downregulates' relationship and to breast carcinoma via an 'associated with' relationship. One of these genes has a reported log2 fold change of -1.181 and an adjusted p-value of 0.02027 in a specific study. Which biological process is connected to this specific... | DNA damage response | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04892","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Cardiovirus A via a 'downregulates' relationship and to breast carcinoma via an 'associ... | |
medium_hidden_intermediate_04893 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that enables protein kinase activity. One such gene exhibits a log2 fold change of 1.083 and an adjusted p-value of 0.001169. Which protein is encoded by this specific gene? | Atypical kinase COQ8B, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04893","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that enables protein kinase activit... | |
medium_hidden_intermediate_04899 | Human alphaherpesvirus 3 upregulates a gene that is located in the plasma membrane. Evidence for one such gene reports a log2 fold change of 1.831 and an adjusted p-value of 3.482e-10. Which disease is associated with this gene as a biomarker? | schizophrenia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04899","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 upregulates a gene that is located in the plasma membrane. Evidence for one such gene reports a log... | |
medium_hidden_intermediate_04901 | Cardiovirus A upregulates a gene that is involved in the innate immune response. Evidence for one such gene reports a log2 fold change of 1.441 and an adjusted p-value of 0.008389. Which disease is associated with this gene as a biomarker? | psoriasis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04901","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A upregulates a gene that is involved in the innate immune response. Evidence for one such gene reports a log2 f... | |
medium_hidden_intermediate_04902 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables E-box binding. Experimental data for this gene in a cardiomyocyte cell line (study GSE151879) reports a log2 fold change of approximately 3.05 and an adjusted p-value of approximately 0.018. Which biological process is this gene ... | negative regulation of transcription by RNA polymerase II | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04902","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables E-box binding. Experimental data ... | |
medium_hidden_intermediate_04904 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the apoptotic process. Evidence for one such gene reports a log2 fold change of 1.311 and an adjusted p-value of 0.001198. Which cell type is this gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04904","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the apoptotic process. Evidence... | |
medium_hidden_intermediate_04905 | Two genes are structurally linked from Pegivirus C via downregulation and subsequently to YWHAG via interaction. One of these genes exhibits a log2 fold change of -2.044 and an adjusted p-value of 0.01977 in the specified dataset. Which cell type is enriched for this specific gene? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04905","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Pegivirus C via downregulation and subsequently to YWHAG via interaction. One of thes... | |
medium_hidden_intermediate_04906 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate certain genes that are located in the mitochondrial matrix. One such gene exhibited a log2 fold change of 1.763 and an adjusted p-value of 9.746e-10. Which protein is encoded by this specific gene? | Tryptophan--tRNA ligase, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04906","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate certain genes that ... | |
medium_hidden_intermediate_04907 | Two genes are structurally linked to Enterovirus A via a downregulation relationship and to natural killer cells via an enrichment relationship. One of these genes is associated with a log2 fold change of approximately -1.262 and an adjusted p-value of 0.002361 in rhabdomyosarcoma cells. Which protein is encoded by thi... | Choline transporter-like protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04907","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Enterovirus A via a downregulation relationship and to natural killer cells via an enri... | |
medium_hidden_intermediate_04908 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is downregulated and its product is located in the membrane. Evidence for this gene reports a log2 fold change of -1.031 and an adjusted p-value of 2.702e-07. Which protein is encoded by this gene? | Chitinase domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04908","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is downregulated and... | |
medium_hidden_intermediate_04909 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to downregulate certain genes that are located in the peroxisomal membrane. One such gene exhibited a log2 fold change of -1.407 and an adjusted p-value of 0.00665. Which protein is encoded by this specific gene? | Dehydrogenase/reductase SDR family member 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04909","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to downregulate certain genes that are l... | |
medium_hidden_intermediate_04910 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and involved in the DNA damage response was found to have a log2 fold change of 1.434 and an adjusted p-value of 0.02304. Which disease is associated with this specific gene? | infectious mononucleosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04910","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and involved in the DNA da... | |
medium_hidden_intermediate_04911 | Zika virus downregulates a specific gene, which in turn interacts with LSM14A. Experimental data for this intermediate gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.39 and an adjusted p-value of 0.0245. Which protein is encoded by this gene? | Enhancer of mRNA-decapping protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04911","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with LSM14A. Experimental data for this intermediate gene ... | |
medium_hidden_intermediate_04912 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific gene that enables RNA binding. This gene exhibited a log2 fold change of approximately -1.378 and an adjusted p-value of 0.02015. Which protein is encoded by this gene? | Protein FAM133B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04912","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific g... | |
medium_hidden_intermediate_04914 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and binds to NCBP1. This specific gene exhibits a log2 fold change of 1.242 and an adjusted p-value of 0.004194. Which protein is encoded by this gene? | U7 snRNA-associated Sm-like protein LSm10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04914","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and binds to NCBP1. Thi... | |
medium_hidden_intermediate_04915 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a specific histone variant that participates in the assembly of the pre-replicative complex. This variant exhibits a log2 fold change of approximately 3.89 and an adjusted p-value of 0.0052. Which protein is encoded by this upregula... | Histone H3.2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04915","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a specific histone variant that part... | |
medium_hidden_intermediate_04917 | Vaccinia virus upregulates a gene that participates in the metabolism of carbohydrates and carbohydrate derivatives. Evidence for this gene in cervical adenocarcinoma cells (study GSE11238) reports a log2 fold change of approximately 1.75 and an adjusted p-value of approximately 4.67e-08. Which cellular component is th... | membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04917","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a gene that participates in the metabolism of carbohydrates and carbohydrate derivatives. Evidenc... | |
medium_hidden_intermediate_04919 | Pegivirus C is reported to downregulate multiple genes that enable 1-acylglycerol-3-phosphate O-acyltransferase activity. One such gene exhibits a log2 fold change of -1.275 and an adjusted p-value of 0.01101 in peripheral blood mononuclear cells (study GSE131504). Which protein is encoded by this specific gene? | Lysocardiolipin acyltransferase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04919","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate multiple genes that enable 1-acylglycerol-3-phosphate O-acyltransferase activity. On... | |
medium_hidden_intermediate_04921 | Zika virus upregulates a gene that participates in axon guidance. Evidence for this gene reports a log2 fold change of 1.884 and an adjusted p-value of 0.01268. Which molecular function is enabled by this gene? | sequence-specific double-stranded DNA binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04921","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that participates in axon guidance. Evidence for this gene reports a log2 fold change of 1.884... |
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