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medium_hidden_intermediate_04922 | Pegivirus C is reported to downregulate a specific gene, which in turn participates in Interleukin-1 signaling. Experimental data from a study on peripheral blood mononuclear cells (GSE131504) indicates that this gene has a log2 fold change of approximately -1.73 and an adjusted p-value of 0.000335. Which protein is en... | 26S proteasome regulatory subunit 10B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04922","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn participates in Interleukin-1 signaling. Experimental... | |
medium_hidden_intermediate_04923 | Human betaherpesvirus 5 downregulates a gene that interacts with CCNF. Experimental data for one such gene in foreskin fibroblast cell lines reports a log2 fold change of approximately -1.017 and an adjusted p-value of 0.0001353. Which molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04923","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 downregulates a gene that interacts with CCNF. Experimental data for one such gene in foreskin fibro... | |
medium_hidden_intermediate_04924 | VSIR is involved in a biological process that is a subtype of negative regulation of cytokine production. Evidence for one such process states: 'Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.' Which biological process is... | interleukin-17 production | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04924","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"VSIR is involved in a biological process that is a subtype of negative regulation of cytokine production. Evidence for one s... | |
medium_hidden_intermediate_04927 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and its product is located in the nucleolus. This gene exhibits a log2 fold change of approximately 1.816 and an adjusted p-value of approximately 1.903e-05. Which protein is encoded by this gene? | CDKN2A-interacting protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04927","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and i... | |
medium_hidden_intermediate_04929 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables phosphatidylinositol-4,5-bisphosphate binding. Evidence for this gene reports a log2 fold change of -1.533 and an adjusted p-value of 0.04867. Which disease is connected to this gene through genomic alterations? | coronary artery disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04929","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables phosphatidylinositol-4,5-bispho... | |
medium_hidden_intermediate_04930 | In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and interacts with RPA2. This gene exhibits a log2 fold change of 1.689 and an adjusted p-value of 0.007582. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04930","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and interacts with RPA2. This... | |
medium_hidden_intermediate_04931 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the regulation of heart contraction. Evidence for this gene reports a log2 fold change of 1.616 and an adjusted p-value of 0.01553. Which disease is connected to this gene through genomic alterations? | Alzheimer disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04931","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the regulation of heart co... | |
medium_hidden_intermediate_04933 | Human betaherpesvirus 5 is reported to upregulate a gene that is enriched in eosinophils. One such gene exhibits a log2 fold change of 2.310 and an adjusted p-value of 0.01427 in foreskin fibroblast cell lines. Which protein is encoded by this specific gene? | Type 2 lactosamine alpha-2,3-sialyltransferase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04933","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to upregulate a gene that is enriched in eosinophils. One such gene exhibits a log2 fold... | |
medium_hidden_intermediate_04934 | Human betaherpesvirus 5 is known to downregulate certain genes that participate in Signaling by Receptor Tyrosine Kinases. One such gene exhibits a log2 fold change of -2.412 and an adjusted p-value of 0.001566 in foreskin fibroblast cell lines. Which disease is associated with this specific gene as a biomarker? | hypertensive disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04934","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is known to downregulate certain genes that participate in Signaling by Receptor Tyrosine Kinases. O... | |
medium_hidden_intermediate_04935 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the positive regulation of microtubule polymerization. One of these genes exhibits a log2 fold change of -2.574 and an adjusted p-value of 0.04485 in a specific study. Which disease is associated with this specific ... | neurodevelopmental disorder with poor or absent speech, dysmorphic facies, and behavioral abnormalities | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04935","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the positive regula... | |
medium_hidden_intermediate_04937 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the upregulation of certain genes that subsequently bind to RBBP7. One such intermediate gene exhibits a log2 fold change of approximately 1.555 and an adjusted p-value of 4.558e-08. Which gene interacts with this specific interme... | RSAD2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04937","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the upregulation of certain genes ... | |
medium_hidden_intermediate_04939 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and involved in RNA processing. Evidence for this gene reports a log2 fold change of 2.112 and an adjusted p-value of 0.00226. Which protein is encoded by this gene? | RNA-binding motif, single-stranded-interacting protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04939","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and involved i... | |
medium_hidden_intermediate_04940 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is downregulated by the virus and participates in protein metabolism. This gene exhibits a log2 fold change of approximately -1.04 and an adjusted p-value of 0.01996. Which protein is encoded by this gene? | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04940","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is downregulated by ... | |
medium_hidden_intermediate_04941 | GNAI1 binds to a specific protein that enables protein binding. Evidence regarding this protein states: 'The coimmunoprecipitation of hTAS2R16 and RTP3 or RTP4 suggests that the mechanism by which these cofactors influence hTAS2R16 function might involve direct protein-protein interaction.' Which disease is connected t... | colorectal carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04941","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"GNAI1 binds to a specific protein that enables protein binding. Evidence regarding this protein states: 'The coimmunoprecipi... | |
medium_hidden_intermediate_04942 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and associated with sarcoma. This specific gene exhibits a log2 fold change of approximately 1.20 and an adjusted p-value of approximately 0.035. Which protein is encoded by this gene? | Protein phosphatase EYA3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04942","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and associated with sar... | |
medium_hidden_intermediate_04944 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and associated with familial non-Hodgkin lymphoma through genomic alterations. Experimental data for this gene reports a log2 fold change of approximately 1.45 and an adjusted p-value of approximately 0.0306. Which protein is encoded by this... | CD70 antigen | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04944","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and associated with familial non-Hodgkin lymp... | |
medium_hidden_intermediate_04946 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with MTA2. One of these genes shows a log2 fold change of approximately -1.16 and an adjusted p-value of 0.0334 in a specific study. Which protein is encoded by this gene? | Serine/threonine-protein phosphatase 4 regulatory subunit 3A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04946","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and interact with MTA2. One of these ge... | |
medium_hidden_intermediate_04948 | Two genes are upregulated by Vaccinia virus and participate in fatty acid metabolism. One of these genes exhibits a log2 fold change of approximately 1.66 and an adjusted p-value of 0.001397 in cervical adenocarcinoma cell lines. Which disease is associated with genomic alterations in this specific gene? | childhood myelodysplastic syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04948","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and participate in fatty acid metabolism. One of these genes exhibits a log2 fol... | |
medium_hidden_intermediate_04949 | Zika virus downregulates a gene that participates in peptide hormone metabolism. Evidence for this gene in glioma stem cells reports a log2 fold change of approximately -1.50 and an adjusted p-value of approximately 0.0124. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04949","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in peptide hormone metabolism. Evidence for this gene in glioma stem cells... | |
medium_hidden_intermediate_04951 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with UBC. Evidence for one such gene reports a log2 fold change of 2.339 and an adjusted p-value of 0.009821. Which molecular function is enabled by that gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04951","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with UBC. Evidence for one such gene... | |
medium_hidden_intermediate_04952 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that participates in Complex I biogenesis. This specific gene exhibited a log2 fold change of -1.261 and an adjusted p-value of 0.01835. Which protein is encoded by this gene? | FAD-dependent oxidoreductase domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04952","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that participates in ... | |
medium_hidden_intermediate_04954 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in Inositol phosphate metabolism. One of these genes exhibits a log2 fold change of approximately -2.03 and an adjusted p-value of 0.044 in bronchial epithelial cells. Which disease is associated with this specific gene... | glioma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04954","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in Inositol phosphate m... | |
medium_hidden_intermediate_04956 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the regulation of T cell activation by the CD28 family. One of these genes shows a log2 fold change of 1.322 and an adjusted p-value of 0.02883 in bronchial epithelial cells. Which disease is associated with this speci... | subarachnoid hemorrhage | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04956","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the regulation of T ce... | |
medium_hidden_intermediate_04961 | Two genes are structurally linked to GRB2 via a binding interaction and subsequently to the 'Signaling by Receptor Tyrosine Kinases' pathway via participation. One of these entities is described as a protein that binds the intracellular adaptor protein GRB2, a feature indicating its intracellular localization. Which ce... | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04961","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to GRB2 via a binding interaction and subsequently to the 'Signaling by Receptor Tyrosine ... | |
medium_hidden_intermediate_04962 | Zaire ebolavirus infection leads to the upregulation of certain genes that participate in biological oxidations. In a study of retinal pigment epithelium cells (GSE100839), one such gene exhibited a log2 fold change of 1.144 and an adjusted p-value of 0.0429. Which protein is encoded by this specific gene? | Protein-tyrosine sulfotransferase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04962","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus infection leads to the upregulation of certain genes that participate in biological oxidations. In a study ... | |
medium_hidden_intermediate_04963 | Zika virus upregulates a gene that is associated with hyperlipidemia. Evidence for this gene reports a log2 fold change of 1.344 and an adjusted p-value of 0.04082. Which protein is encoded by this gene? | Chloride intracellular channel protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04963","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that is associated with hyperlipidemia. Evidence for this gene reports a log2 fold change of 1... | |
medium_hidden_intermediate_04965 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes involved in the positive regulation of the apoptotic process. One such gene exhibits a log2 fold change of -2.242 and an adjusted p-value of 0.001621. Which protein is encoded by this specific gene? | Ribosomal protein S6 kinase alpha-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04965","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes invol... | |
medium_hidden_intermediate_04966 | Human immunodeficiency virus 1 downregulates a gene that participates in the synthesis of substrates in N-glycan biosynthesis. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of -1.135 and an adjusted p-value of 0.01015. Which disease is associated with this gene? | polycystic kidney disease 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04966","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in the synthesis of substrates in N-glycan biosynthesi... | |
medium_hidden_intermediate_04967 | Measles morbillivirus upregulates a specific gene, which is associated with bone resorption disease. Transcriptomic data for this gene in study GSE131840 reports a log2 fold change of 3.218 and an adjusted p-value of 0.01966. Which disease is causally linked to this gene? | megacolon | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04967","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a specific gene, which is associated with bone resorption disease. Transcriptomic data for... | |
medium_hidden_intermediate_04969 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with melanoma. One of these genes exhibits a log2 fold change of -1.130 and an adjusted p-value of 0.04357 in a specific study. Which protein is encoded by this gene? | Band 4.1-like protein 4B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04969","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with melanoma. One o... | |
medium_hidden_intermediate_04970 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in cell-cell signaling. Evidence for this gene reports a log2 fold change of 1.495 and an adjusted p-value of 0.0316. Which disease is associated with this gene? | polymicrogyria, bilateral perisylvian, autosomal recessive | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04970","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in cell-cell signaling. Evide... | |
medium_hidden_intermediate_04971 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Extracellular matrix organization. Transcriptomic data for this gene in choroid plexus epithelium shows a log2 fold change of -1.520 and an adjusted p-value of 0.0165. Which protein is encoded by this gene? | Neurocan core protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04971","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Extracellular matrix or... | |
medium_hidden_intermediate_04974 | Zika virus upregulates a specific gene that participates in infectious disease processes. Transcriptomic data from glioblastoma multiforme cancer stem cells (study GSE102924) indicates this gene has a log2 fold change of approximately 1.25 and an adjusted p-value of 0.0229. In which cellular component is this gene prod... | endoplasmic reticulum | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04974","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a specific gene that participates in infectious disease processes. Transcriptomic data from glioblast... | |
medium_hidden_intermediate_04975 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in small GTPase-mediated signal transduction. Evidence for this gene reports a log2 fold change of 3.048 and an adjusted p-value of 0.04766. Which protein is encoded by this gene? | Ras guanyl-releasing protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04975","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in small GTPase-mediated signal tr... | |
medium_hidden_intermediate_04976 | A gene is upregulated by Zika virus and located in the endoplasmic reticulum membrane. Evidence for this gene reports a log2 fold change of 1.437 and an adjusted p-value of 0.008249. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04976","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Zika virus and located in the endoplasmic reticulum membrane. Evidence for this gene reports a log2... | |
medium_hidden_intermediate_04977 | In a study of Measles morbillivirus infection, two genes are known to be downregulated by the virus and to participate in the Generic Transcription Pathway. One of these genes exhibits a log2 fold change of approximately -1.034 and an adjusted p-value of 0.04211. What molecular function is enabled by this specific gene... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04977","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, two genes are known to be downregulated by the virus and to participate in th... | |
medium_hidden_intermediate_04979 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific gene, which is associated with disease. The expression data for this gene shows a log2 fold change of -3.054 and an adjusted p-value of 0.03958. Which protein is encoded by this gene? | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04979","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific g... | |
medium_hidden_intermediate_04980 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the positive regulation of the MAPK cascade. One of these genes exhibits a log2 fold change of approximately 2.11 and an adjusted p-value of 0.02991 in lung tissue. Which cellular component is the location of this spe... | extracellular space | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04980","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the positive regulati... | |
medium_hidden_intermediate_04981 | A gene is upregulated by Vaccinia virus and participates in Interleukin-10 signaling. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately 3.73 and an adjusted p-value of approximately 8.85e-08. Which disease is associated with this gene thr... | multiple sclerosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04981","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Vaccinia virus and participates in Interleukin-10 signaling. Experimental data for this gene in a c... | |
medium_hidden_intermediate_04982 | In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upregulate a specific gene that enables protein kinase binding. This gene exhibited a log2 fold change of approximately 1.609 and an adjusted p-value of 0.006892. Which protein is encoded by this gene? | Guanine nucleotide exchange protein SMCR8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04982","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upreg... | |
medium_hidden_intermediate_04986 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with glioma. One of these genes exhibits a log2 fold change of approximately 1.097 and an adjusted p-value of 0.02078 in sclera cells (study GSE164073). Which biological process is this specific gene involved in? | electron transport chain | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04986","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with glioma. One of th... | |
medium_hidden_intermediate_04987 | Two distinct proteins are known to interact with both envoplakin (EVPL) and transglutaminase 1 (TGM1). One of these proteins is characterized by an N-terminal domain that interacts with the plasma membrane, a rod domain that mediates heterodimerization with envoplakin, and a C-terminus that interacts with intermediate ... | response to mechanical stimulus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04987","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct proteins are known to interact with both envoplakin (EVPL) and transglutaminase 1 (TGM1). One of these proteins... | |
medium_hidden_intermediate_04988 | Zika virus downregulates a gene that participates in RNA Polymerase III Transcription Initiation From Type 3 Promoter. Experimental data from glioma stem cells (study GSE114907) indicates this gene has a log2 fold change of approximately -2.67 and an adjusted p-value of approximately 0.009. Which protein is encoded by ... | Transcription factor IIIB 50 kDa subunit | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04988","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in RNA Polymerase III Transcription Initiation From Type 3 Promoter. Exper... | |
medium_hidden_intermediate_04990 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in turn participates in the Cell Cycle. This gene exhibited a log2 fold change of approximately -1.17 and an adjusted p-value of approximately 0.0087. Which protein is encoded by this gene? | H/ACA ribonucleoprotein complex subunit 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04990","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in tu... | |
medium_hidden_intermediate_04991 | A gene is upregulated by Primate bocaparvovirus 1 and participates in the Respiratory Syncytial Virus Infection Pathway. Evidence for this gene reports a log2 fold change of 10.419 and an adjusted p-value of 0.03055. Which protein is encoded by this gene? | Interferon beta | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04991","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and participates in the Respiratory Syncytial Virus Infection Pathway. Evi... | |
medium_hidden_intermediate_04993 | A gene is downregulated by Human immunodeficiency virus 1 and enables protein homodimerization activity. Evidence for this gene reports a log2 fold change of -1.128 and an adjusted p-value of 0.0433. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04993","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Human immunodeficiency virus 1 and enables protein homodimerization activity. Evidence for this g... | |
medium_hidden_intermediate_04997 | Human betaherpesvirus 5 is reported to downregulate a gene that participates in the metabolism of proteins. In a study using foreskin fibroblast cell lines, this gene exhibited a log2 fold change of approximately -1.46 and an adjusted p-value of approximately 0.043. Which protein interacts with this gene product? | HECTD1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04997","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that participates in the metabolism of proteins. In a study using... | |
medium_hidden_intermediate_04998 | Severe acute respiratory syndrome-related coronavirus downregulates multiple genes that are located on the external side of the plasma membrane. One such gene exhibits a log2 fold change of -1.071 and an adjusted p-value of 7.299e-05. Which protein is encoded by this specific gene? | Tissue factor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04998","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates multiple genes that are located on the external side of ... | |
medium_hidden_intermediate_04999 | HSP90AA1 interacts with a specific protein that enables protein binding. Evidence indicates that structural and kinetic characterization of this protein led to a co-crystal structure with a MEKK2-peptide substrate bound. Which cellular component is this protein located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_04999","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"HSP90AA1 interacts with a specific protein that enables protein binding. Evidence indicates that structural and kinetic char... | |
medium_hidden_intermediate_05000 | Human immunodeficiency virus 1 upregulates a gene that participates in collagen degradation. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of 2.784 and an adjusted p-value of 0.001801. Which disease is associated with this gene? | hyperplasia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05000","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in collagen degradation. Evidence for this gene in macro... | |
medium_hidden_intermediate_05001 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the positive regulation of gene expression. Evidence for this gene reports a log2 fold change of 1.119 and an adjusted p-value of 0.0004612. Which disease is connected to this gene through genomic alterations? | peroxisome biogenesis disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05001","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the positive regulation of... | |
medium_hidden_intermediate_05002 | Zika virus downregulates a gene that participates in autophagy. In a study of glioma stem cells (GSE114907), one such gene showed a log2 fold change of -2.138 and an adjusted p-value of 0.04331. Which protein is encoded by this gene? | Protein Atg16l2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05002","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in autophagy. In a study of glioma stem cells (GSE114907), one such gene s... | |
medium_hidden_intermediate_05003 | Two genes are each downregulated by Measles morbillivirus and associated with adenoviridae infectious disease. One of these genes exhibits a log2 fold change of -1.839 and an adjusted p-value of 0.00733 in study GSE131840. Which gene interacts with the gene identified by these statistical values? | SAA2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05003","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each downregulated by Measles morbillivirus and associated with adenoviridae infectious disease. One of these ... | |
medium_hidden_intermediate_05004 | Gliomas can be localized to various brain ventricles. One such ventricle is described as part of the ventricular system, forming a single large irregularly shaped cavity located on the midline of the rhombencephalon, between the medulla, pons, and the isthmus ventrally and the cerebellum dorsally. It is continuous with... | hindbrain vesicle | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05004","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Gliomas can be localized to various brain ventricles. One such ventricle is described as part of the ventricular system, for... | |
medium_hidden_intermediate_05005 | Cardiovirus A downregulates a gene that is involved in double-strand break repair via homologous recombination. In a study of cervical adenocarcinoma cell lines (GSE122967), one such gene exhibited a log2 fold change of -2.616 and an adjusted p-value of 0.01929. Which protein interacts with this specific gene product? | SLX4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05005","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A downregulates a gene that is involved in double-strand break repair via homologous recombination. In a study o... | |
medium_hidden_intermediate_05006 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated by the virus and its product binds to PAK1. Experimental data for this gene in lung tissue reports a log2 fold change of -1.526 and an adjusted p-value of 0.03966. Which protein is encoded by this gene? | Ephrin-B2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05006","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated by the virus... | |
medium_hidden_intermediate_05007 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in DNA Replication. Experimental data for this gene in alveolar type II cells (study GSE153277) reports a log2 fold change of -1.291 and an adjusted p-value of 0.03752. Which disease is associated with this gene? | Meier-Gorlin syndrome 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05007","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in DNA Replication. Experi... | |
medium_hidden_intermediate_05008 | Zika virus downregulates multiple genes that participate in G alpha (s) signalling events. One such gene exhibits a log2 fold change of -1.614 and an adjusted p-value of 0.03037 in glioma stem cells. Which protein interacts with this specific gene product? | SERTAD1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05008","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates multiple genes that participate in G alpha (s) signalling events. One such gene exhibits a log2 fol... | |
medium_hidden_intermediate_05009 | Human betaherpesvirus 5 is reported to downregulate a gene that enables RNA binding. In a study of foreskin fibroblast cell lines (GSE111036), one such gene exhibited a log2 fold change of -1.714 and an adjusted p-value of 0.0346. Which protein is encoded by this specific gene? | ATP-dependent RNA helicase DHX29 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05009","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that enables RNA binding. In a study of foreskin fibroblast cell ... | |
medium_hidden_intermediate_05010 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via downregulation and to bipolar disorder via biomarker association. One of these genes exhibits a log2 fold change of -1.901 and an adjusted p-value of 0.0001013 in choroid plexus epithelium. Which biological process is this specific gene i... | nervous system development | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05010","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via downregulation and to bipolar disorder via... | |
medium_hidden_intermediate_05012 | Human betaherpesvirus 5 upregulates a gene that participates in the Innate Immune System. Experimental data from foreskin fibroblast cell lines (study GSE132081) indicates that this specific gene has a log2 fold change of approximately 1.58 and an adjusted p-value of approximately 0.0084. Which protein is encoded by th... | Elafin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05012","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that participates in the Innate Immune System. Experimental data from foreskin fi... | |
medium_hidden_intermediate_05013 | A gene is downregulated by Zika virus and enriched in regulatory T cells. Evidence for this gene reports a log2 fold change of -1.111 and an adjusted p-value of 0.0167. Which disease is associated with this gene through genomic alterations? | adult glioblastoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05013","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Zika virus and enriched in regulatory T cells. Evidence for this gene reports a log2 fold change ... | |
medium_hidden_intermediate_05014 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the negative regulation of the apoptotic process. Evidence for one such gene reports a log2 fold change of 1.085 and an adjusted p-value of 0.04887. Which protein does this gene product bind to? | YME1L1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05014","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the negative regulation of the ... | |
medium_hidden_intermediate_05015 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific gene involved in Asparagine N-linked glycosylation. This gene exhibited a log2 fold change of -1.218 and an adjusted p-value of 0.02872. Which protein is encoded by this gene? | N-acetylneuraminate lyase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05015","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific g... | |
medium_hidden_intermediate_05016 | Hepacivirus C downregulates a gene that is located on the cell surface. Evidence for this specific gene reports a log2 fold change of -1.249 and an adjusted p-value of 0.04458. Which biological process is this gene involved in? | cell-cell adhesion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05016","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a gene that is located on the cell surface. Evidence for this specific gene reports a log2 fold ... | |
medium_hidden_intermediate_05018 | Influenza A virus downregulates a specific gene that is located in the nucleus. Experimental data for this gene shows a log2 fold change of -1.134 and an adjusted p-value of 8.408e-12. In which cell type is this gene enriched? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05018","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Influenza A virus downregulates a specific gene that is located in the nucleus. Experimental data for this gene shows a log2... | |
medium_hidden_intermediate_05019 | Two genes are linked to Natural killer T cells via a 'has marker' relationship and to renal cell carcinoma via an 'associated with' relationship. One of these genes is identified in experimental evidence as a ~21 kDa cytosolic protein detected by Western blotting in human breast cancer (MDA-MB 231) and renal carcinoma ... | esophageal squamous cell carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05019","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Natural killer T cells via a 'has marker' relationship and to renal cell carcinoma via an 'associate... | |
medium_hidden_intermediate_05021 | Human alphaherpesvirus 1 upregulates a gene that participates in metabolism. Evidence for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately 1.08 and an adjusted p-value of 0.022. Which disease is associated with this gene? | alcoholic liver cirrhosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05021","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that participates in metabolism. Evidence for this gene in a monocytic leukemia ... | |
medium_hidden_intermediate_05023 | Human immunodeficiency virus 1 is reported to downregulate a gene that is associated with cervical cancer. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of -1.726 and an adjusted p-value of 0.003843. Which protein is encoded by this gene? | Polypeptide N-acetylgalactosaminyltransferase 15 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05023","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 is reported to downregulate a gene that is associated with cervical cancer. In a study of mac... | |
medium_hidden_intermediate_05025 | A gene is downregulated by Measles morbillivirus and is enriched in plasmacytoid dendritic cells. Evidence for this gene reports a log2 fold change of -1.431 and an adjusted p-value of 0.0001376. Which protein is encoded by this gene? | Papilin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05025","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Measles morbillivirus and is enriched in plasmacytoid dendritic cells. Evidence for this gene rep... | |
medium_hidden_intermediate_05026 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is located in the mitochondrial outer membrane. Evidence for one such gene reports a log2 fold change of -1.051 and an adjusted p-value of 0.03174. Which protein is encoded by that gene? | Kynurenine 3-monooxygenase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05026","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is located in the mitochondrial outer membra... | |
medium_hidden_intermediate_05028 | In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and participates in the Neuronal System. This specific gene exhibits a log2 fold change of 2.356 and an adjusted p-value of 0.02207. Which protein is encoded by this gene? | Voltage-gated potassium channel regulatory subunit KCNF1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05028","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and participates in the Neuro... | |
medium_hidden_intermediate_05030 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a gene is identified that is downregulated by the virus and involved in the proteasome-mediated ubiquitin-dependent protein catabolic process. Evidence for this gene reports a log2 fold change of -1.471 and an adjusted p-value of 0.03203. Wh... | SPRY domain-containing SOCS box protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05030","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a gene is identified that is downregulated by... | |
medium_hidden_intermediate_05031 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes that are located in the actin cytoskeleton. One such gene exhibited a log2 fold change of 2.219 and an adjusted p-value of 8.708e-05. Which protein is encoded by this specific gene? | Smoothelin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05031","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes ... | |
medium_hidden_intermediate_05033 | Human betaherpesvirus 5 downregulates a gene that is located in the endoplasmic reticulum membrane. Evidence for this gene reports a log2 fold change of -1.196 and an adjusted p-value of 0.04515. Which gene binds to this entity? | PIGX | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05033","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 downregulates a gene that is located in the endoplasmic reticulum membrane. Evidence for this gene r... | |
medium_hidden_intermediate_05035 | Enterovirus A is reported to upregulate a gene that serves as a biomarker for breast cancer. In a study involving rhabdomyosarcoma cells (GSE103308), one such gene exhibits a log2 fold change of approximately 3.43 and an adjusted p-value of approximately 0.018. What molecular function is enabled by this specific gene? | choline-phosphate cytidylyltransferase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05035","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is reported to upregulate a gene that serves as a biomarker for breast cancer. In a study involving rhabdomyos... | |
medium_hidden_intermediate_05036 | CUL3 interacts with a specific adaptor protein that is part of the Cul3-RING ubiquitin ligase complex. Research has identified the complex formed by this adaptor and CUL3 as an E3 ubiquitin ligase that targets hypophosphorylated 4E-BP1. Which protein is encoded by the gene corresponding to this adaptor? | Kelch-like protein 25 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05036","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"CUL3 interacts with a specific adaptor protein that is part of the Cul3-RING ubiquitin ligase complex. Research has identifi... | |
medium_hidden_intermediate_05037 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated by the virus and interacts with HSP90AB1. This gene exhibits a log2 fold change of 3.217 and an adjusted p-value of 0.004124. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05037","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated by the virus a... | |
medium_hidden_intermediate_05039 | In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and enables ubiquitin-like ligase-substrate adaptor activity. This specific gene exhibits a log2 fold change of -1.235 and an adjusted p-value of 0.02296. Which cellular component is this gene located in? | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05039","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is downregulated by Human immunodeficiency virus 1 and enab... | |
medium_hidden_intermediate_05040 | Human immunodeficiency virus 1 downregulates a gene that participates in SLC-mediated transmembrane transport. Evidence for this gene in macrophages (study GSE108897) reports a log2 fold change of -1.857 and an adjusted p-value of 0.009511. Which protein is encoded by this gene? | Sodium-coupled neutral amino acid transporter 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05040","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in SLC-mediated transmembrane transport. Evidence for ... | |
medium_hidden_intermediate_05041 | Pegivirus C is reported to downregulate a specific gene, which is subsequently involved in the positive regulation of transcription by RNA polymerase II. Experimental data for this gene in peripheral blood mononuclear cells (from study GSE131504) indicate a log2 fold change of approximately -2.35 and an adjusted p-valu... | RNA-binding protein 14 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05041","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which is subsequently involved in the positive regulation of transc... | |
medium_hidden_intermediate_05042 | Human alphaherpesvirus 1 upregulates a gene that is enriched in basophils. Evidence for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of 4.126 and an adjusted p-value of 0.01047. Which protein is encoded by this gene? | Nucleolar and spindle-associated protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05042","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that is enriched in basophils. Evidence for this gene in a monocytic leukemia ce... | |
medium_hidden_intermediate_05044 | A gene is downregulated by Human gammaherpesvirus 8 and is involved in cell population proliferation. Experimental data for this gene in lymphatic endothelial cells from study GSE16354 reports a log2 fold change of -1.270 and an adjusted p-value of 0.03974. Which disease is associated with this gene as a biomarker? | basal-like breast carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05044","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Human gammaherpesvirus 8 and is involved in cell population proliferation. Experimental data for ... | |
medium_hidden_intermediate_05046 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and participates in the process where Activated NOTCH1 Transmits Signal to the Nucleus. Evidence for this gene reports a log2 fold change of -2.234 and an adjusted p-value of 0.003108. Which protein is encode... | Protein delta homolog 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05046","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is downregulated and particip... | |
medium_hidden_intermediate_05047 | Zika virus downregulates a gene that participates in CS-GAG biosynthesis. In a study of glioma stem cells (GSE114907), one such gene showed a log2 fold change of -1.785 and an adjusted p-value of 0.03271. Which protein is encoded by this gene? | Carbohydrate sulfotransferase 15 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05047","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in CS-GAG biosynthesis. In a study of glioma stem cells (GSE114907), one s... | |
medium_hidden_intermediate_05048 | A gene is connected to CREBBP via a binding interaction and is located in the cytoplasm. Evidence concerning one such entity states: 'We show that transcription factors of the nuclear factor of activated T cells (NFAT) family bind p300/CBP and recruit histone acetyltransferase activity from T cell nuclear extracts.' Wh... | Nuclear factor of activated T-cells, cytoplasmic 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05048","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is connected to CREBBP via a binding interaction and is located in the cytoplasm. Evidence concerning one such entity... | |
medium_hidden_intermediate_05049 | Rhinovirus A downregulates a specific gene, which in turn interacts with STK4. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of -1.201 and an adjusted p-value of 0.0005949. Which protein is encoded by this gene? | Lupus La protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05049","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A downregulates a specific gene, which in turn interacts with STK4. Experimental data for this gene in cytotoxic ... | |
medium_hidden_intermediate_05050 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and interacts with RPAP2. This specific gene exhibits a log2 fold change of approximately 1.008 and an adjusted p-value of 0.0132. Which protein is encoded by this gene? | RNA polymerase II-associated protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05050","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and interacts with RPAP... | |
medium_hidden_intermediate_05051 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to thyroid gland papillary carcinoma via biomarker association. One of these genes exhibits a log2 fold change of 1.114 and an adjusted p-value of 0.0163 in a specific study. Which protein is encoded by this gene? | 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05051","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to thyroid gland papillar... | |
medium_hidden_intermediate_05052 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes located in the cytoplasm. One such gene exhibits a log2 fold change of approximately -1.25 and an adjusted p-value of approximately 0.043. Which protein is encoded by this specific gene? | Mitogen-activated protein kinase kinase kinase 12 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05052","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes locat... | |
medium_hidden_intermediate_05053 | In a study of glioma stem cells (GSE114907), Zika virus infection leads to the downregulation of a specific gene, which in turn encodes a protein that binds to NEK2. The expression data for this gene shows a log2 fold change of -1.777 and an adjusted p-value of 0.01589. Which protein is encoded by this gene? | Anaphase-promoting complex subunit 10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05053","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), Zika virus infection leads to the downregulation of a specific gene, which in t... | |
medium_hidden_intermediate_05054 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to arthritic joint disease via an 'associated with' relationship. One of these genes is reported in a study (GSE150819) involving bronchial epithelial cells, with a log2 fold change of -4.43... | cell surface | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05054","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_05055 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE148697), two genes are downregulated and participate in Signaling by NOTCH. One of these genes exhibits a log2 fold change of -2.433 and an adjusted p-value of 0.001717. Which biological process is the gene with these speci... | alpha-beta T cell differentiation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05055","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE148697), two genes are down... | |
medium_hidden_intermediate_05056 | Two genes are upregulated by Vaccinia virus and associated with prostate cancer. One of these genes exhibits a log2 fold change of 2.177 and an adjusted p-value of 7.952e-05 in cervical adenocarcinoma cell lines (study GSE11238). Which protein is encoded by the gene matching these expression statistics? | D-beta-hydroxybutyrate dehydrogenase, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05056","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and associated with prostate cancer. One of these genes exhibits a log2 fold cha... | |
medium_hidden_intermediate_05057 | Pegivirus C is reported to downregulate a gene that is involved in hemopoiesis. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.024 and an adjusted p-value of 0.001446. Which protein is encoded by this specific gene? | Sialomucin core protein 24 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05057","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in hemopoiesis. In a study of peripheral blood mononuclear c... | |
medium_hidden_intermediate_05058 | In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and its product interacts with VASP. This gene exhibits a log2 fold change of approximately 1.12 and an adjusted p-value of 0.0315. Which protein is encoded by this gene? | Ras-associated and pleckstrin homology domains-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05058","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and its product interacts with VA... | |
medium_hidden_intermediate_05059 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a specific gene involved in the regulation of DNA stability. This gene exhibited a log2 fold change of approximately 1.33 and an adjusted p-value of approximately 0.000436. Which protein is encoded by this gene? | Replication termination factor 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05059","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a specific gene inv... | |
medium_hidden_intermediate_05060 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by the virus and its product binds to RBBP4. This gene exhibits a log2 fold change of approximately 1.175 and an adjusted p-value of 4.632e-08. Which protein is encoded by this gene? | Zinc finger protein AEBP2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05060","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by th... | |
medium_hidden_intermediate_05061 | Pegivirus C is reported to downregulate a specific gene, the product of which binds to CDC26. In a study of peripheral blood mononuclear cells (GSE131504), this gene exhibited a log2 fold change of approximately -1.27 and an adjusted p-value of 0.000195. Which protein is encoded by this gene? | Anaphase-promoting complex subunit 13 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05061","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, the product of which binds to CDC26. In a study of peripheral blood... | |
medium_hidden_intermediate_05062 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the positive regulation of megakaryocyte differentiation. One of these genes exhibits a log2 fold change of -1.473 and an adjusted p-value of 0.03721 in a specific study. Which protein is encoded by this gene? | Ras-related protein Rab-7b | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05062","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the positive regula... |
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