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medium_hidden_intermediate_05063 | Zika virus downregulates a gene that is involved in the regulation of the apoptotic process. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -1.111 and an adjusted p-value of 0.0167. Which protein is encoded by this gene? | Leucine carboxyl methyltransferase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05063","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the regulation of the apoptotic process. In a study of glioma stem cells... | |
medium_hidden_intermediate_05065 | Human immunodeficiency virus 1 upregulates a gene that participates in Glycerophospholipid biosynthesis. Evidence for this gene reports a log2 fold change of 2.327 and an adjusted p-value of 0.02517. Which protein is encoded by this gene? | 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05065","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in Glycerophospholipid biosynthesis. Evidence for this g... | |
medium_hidden_intermediate_05066 | Hepacivirus C is reported to downregulate a gene that is located in the cytosol. One such gene exhibits a log2 fold change of approximately -1.03 and an adjusted p-value of 0.0227 in peripheral blood mononuclear cells. Which protein is encoded by this gene? | dCTP pyrophosphatase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05066","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that is located in the cytosol. One such gene exhibits a log2 fold change o... | |
medium_hidden_intermediate_05069 | Zika virus downregulates a gene that participates in Intra-Golgi and retrograde Golgi-to-ER traffic. Evidence for this gene in glioma stem cells reports a log2 fold change of approximately -2.70 and an adjusted p-value of approximately 0.047. Which cell type is this gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05069","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in Intra-Golgi and retrograde Golgi-to-ER traffic. Evidence for this gene ... | |
medium_hidden_intermediate_05070 | Human immunodeficiency virus 1 downregulates a gene that binds to FZD4. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of -2.533 and an adjusted p-value of 0.01084. Which protein is encoded by this gene? | Protein Wnt-5b | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05070","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that binds to FZD4. In a study of macrophages (GSE108897), one such gene... | |
medium_hidden_intermediate_05072 | In a study of Hepacivirus C infection in peripheral blood mononuclear cells (GSE119117), a specific gene is downregulated by the virus and its product binds to PEX5. This gene exhibits a log2 fold change of -1.316 and an adjusted p-value of 0.0464. Which protein is encoded by this gene? | Peroxisomal N(1)-acetyl-spermine/spermidine oxidase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05072","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Hepacivirus C infection in peripheral blood mononuclear cells (GSE119117), a specific gene is downregulated by... | |
medium_hidden_intermediate_05073 | Pegivirus C is associated with the downregulation of a specific gene, which is in turn enriched in Memory CD4+ T cells. Experimental data for this gene reports a log2 fold change of -1.806 and an adjusted p-value of 0.01797. Which protein is encoded by this gene? | Cilia- and flagella-associated protein 36 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05073","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is associated with the downregulation of a specific gene, which is in turn enriched in Memory CD4+ T cells. Expe... | |
medium_hidden_intermediate_05074 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables cytokine activity. Experimental data for this gene in bronchial epithelial cells shows a log2 fold change of approximately -1.04 and an adjusted p-value of 0.0285. Which disease is associated with this gene as a biomarker? | pneumonia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05074","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables cytokine activity. Experimental... | |
medium_hidden_intermediate_05075 | Hepacivirus C is reported to downregulate a gene that enables DNA-binding transcription repressor activity, RNA polymerase II-specific. In a study of peripheral blood mononuclear cells (GSE119117), one such gene exhibits a log2 fold change of -1.030 and an adjusted p-value of 0.01135. Which protein is encoded by this g... | Zinc finger protein 692 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05075","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that enables DNA-binding transcription repressor activity, RNA polymerase I... | |
medium_hidden_intermediate_05076 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in cyclic-GMP-AMP transmembrane import across the plasma membrane. Evidence for one such gene reports a log2 fold change of -1.143 and an adjusted p-value of 6.434e-05. Which protein is encoded by that gene? | Volume-regulated anion channel subunit LRRC8A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05076","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in cyclic-GMP-AMP transmembrane ... | |
medium_hidden_intermediate_05078 | Two genes are downregulated by Human betaherpesvirus 5 and are associated with adenoviridae infectious disease. One of these genes exhibits a log2 fold change of -1.550 and an adjusted p-value of 0.04516 in foreskin fibroblast cell lines. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05078","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Human betaherpesvirus 5 and are associated with adenoviridae infectious disease. One of these... | |
medium_hidden_intermediate_05079 | CLPP interacts with a protein that is located in the mitochondrial matrix. Evidence indicates that this protein, along with NIPSNAP2, accumulates on the mitochondrial surface upon mitochondrial depolarization. Which biological process is this protein involved in? | mitophagy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05079","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"CLPP interacts with a protein that is located in the mitochondrial matrix. Evidence indicates that this protein, along with ... | |
medium_hidden_intermediate_05081 | Pegivirus C is reported to downregulate a gene that participates in Mitotic Anaphase. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -1.053 and an adjusted p-value of 0.01534. Which protein is encoded by this specific gene? | Protein ELYS | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05081","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that participates in Mitotic Anaphase. In a study of peripheral blood mononuc... | |
medium_hidden_intermediate_05083 | Zika virus downregulates a gene that binds to RSF1. In glioma stem cells, this gene exhibits a log2 fold change of -2.704 and an adjusted p-value of 0.0101. Which protein is encoded by this gene? | Centromere protein L | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05083","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that binds to RSF1. In glioma stem cells, this gene exhibits a log2 fold change of -2.704 an... | |
medium_hidden_intermediate_05084 | Human alphaherpesvirus 1 is reported to upregulate a gene that is associated with colon carcinoma. In a study using a monocytic leukemia cell line (GSE114966), one such gene exhibited a log2 fold change of approximately 1.187 and an adjusted p-value of 0.002873. Which protein is encoded by this specific gene? | GTP-binding protein RAD | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05084","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 is reported to upregulate a gene that is associated with colon carcinoma. In a study using a monocy... | |
medium_hidden_intermediate_05085 | Two genes are upregulated by Influenza A virus and participate in Signaling by Rho GTPases, Miro GTPases and RHOBTB3. One of these genes exhibits a log2 fold change of 1.185 and an adjusted p-value of 7.789e-06 in a specific study. Which disease is associated with this specific gene? | breast carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05085","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Influenza A virus and participate in Signaling by Rho GTPases, Miro GTPases and RHOBTB3. One of... | |
medium_hidden_intermediate_05086 | In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection was found to upregulate certain genes that are enriched in conventional dendritic cells. One such gene exhibited a log2 fold change of 2.321 and an adjusted p-value of 0.003855. Which protein is encoded by this specific... | Armadillo repeat-containing X-linked protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05086","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection was found to upregulate... | |
medium_hidden_intermediate_05087 | Two genes are upregulated by Vaccinia virus and participate in platelet degranulation. One of these genes shows a log2 fold change of 2.595 and an adjusted p-value of 2.507e-05 in cervical adenocarcinoma cell lines. Which disease is associated with this specific gene as a biomarker? | diabetes mellitus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05087","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and participate in platelet degranulation. One of these genes shows a log2 fold ... | |
medium_hidden_intermediate_05088 | Zika virus downregulates a gene that participates in Class I MHC mediated antigen processing & presentation. Evidence for this gene reports a log2 fold change of -3.593 and an adjusted p-value of 0.01643. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05088","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in Class I MHC mediated antigen processing & presentation. Evidence for th... | |
medium_hidden_intermediate_05089 | Hepacivirus C upregulates a gene that is associated with obesity disorder. Evidence for one such gene reports a log2 fold change of 1.622 and an adjusted p-value of 0.002346. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05089","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is associated with obesity disorder. Evidence for one such gene reports a log2 fold ch... | |
medium_hidden_intermediate_05090 | Two genes are upregulated by Vaccinia virus and interact with SOCS6. One of these genes exhibits a log2 fold change of approximately 2.32 and an adjusted p-value of 1.702e-06 in cervical adenocarcinoma cells. Which biological process is this specific gene involved in? | negative regulation of cold-induced thermogenesis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05090","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and interact with SOCS6. One of these genes exhibits a log2 fold change of appro... | |
medium_hidden_intermediate_05092 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the defense response to virus. Experimental data for this gene in a lung adenocarcinoma cell line (study GSE147507) reports a log2 fold change of approximately 2.191 and an adjusted p-value of approximately 0.01918. Which ... | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05092","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the defense response to vi... | |
medium_hidden_intermediate_05093 | Zika virus upregulates a gene that participates in the Adaptive Immune System. Evidence for one such gene reports a log2 fold change of 1.216 and an adjusted p-value of 0.02286. Which protein is encoded by that gene? | Butyrophilin subfamily 2 member A2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05093","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that participates in the Adaptive Immune System. Evidence for one such gene reports a log2 fol... | |
medium_hidden_intermediate_05094 | In a study of cervical adenocarcinoma cell lines (GSE122967), a gene is identified that is downregulated by Cardiovirus A and interacts with UBC. This specific gene exhibits a log2 fold change of -1.257 and an adjusted p-value of 0.01988. Which disease is associated with this gene? | glioblastoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05094","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), a gene is identified that is downregulated by Cardiovirus A an... | |
medium_hidden_intermediate_05095 | Two genes are structurally linked from Hepacivirus C via a 'downregulates' relationship and subsequently to Classical monocyte via an 'enriched in' relationship. One of these genes is associated with experimental data showing a log2 fold change of approximately -1.747 and an adjusted p-value of 0.01493. Which gene inte... | SULT2B1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05095","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Hepacivirus C via a 'downregulates' relationship and subsequently to Classical monocy... | |
medium_hidden_intermediate_05096 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in ion homeostasis. Evidence for one such gene reports a log2 fold change of 3.349 and an adjusted p-value of 0.0005312. Which protein is encoded by that gene? | FXYD domain-containing ion transport regulator 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05096","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in ion homeostasis. Evidence for ... | |
medium_hidden_intermediate_05097 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus was found to downregulate a gene that is involved in the positive regulation of vascular associated smooth muscle cell proliferation. This specific gene exhibited a log2 fold change of approximately -1.31 and an adjusted p-value of 0.0001008. W... | Gap junction alpha-1 protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05097","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus was found to downregulate a gene that is involve... | |
medium_hidden_intermediate_05098 | Zaire ebolavirus upregulates a gene that is located in the mitochondrion. In a study of retinal pigment epithelium cells (GSE100839), one such gene exhibited a log2 fold change of approximately 1.274 and an adjusted p-value of 0.01458. Which protein does this specific gene product bind to? | SMDT1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05098","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus upregulates a gene that is located in the mitochondrion. In a study of retinal pigment epithelium cells (GS... | |
medium_hidden_intermediate_05100 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection was found to upregulate genes located in the centrosome. One such gene exhibited a log2 fold change of approximately 3.15 and an adjusted p-value of approximately 0.0012. Which protein is encoded by this specific gene? | Coiled-coil domain-containing protein 15 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05100","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection was found to upregulate genes located ... | |
medium_hidden_intermediate_05101 | Human immunodeficiency virus 1 downregulates a gene that participates in Antigen processing: Ubiquitination & Proteasome degradation. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of -1.683 and an adjusted p-value of 0.04628. Which gene interacts with this specific downregulated gene... | UBE2L3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05101","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in Antigen processing: Ubiquitination & Proteasome deg... | |
medium_hidden_intermediate_05102 | A gene serves as a marker for monocytes and is enriched in basophils. Evidence for this gene includes a mean expression of 33.94 TPM, a z-score of 1.52, and a fold enrichment of 3.78. Which disease is associated with this gene as a therapeutic target? | gout | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05102","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for monocytes and is enriched in basophils. Evidence for this gene includes a mean expression of 3... | |
medium_hidden_intermediate_05103 | Human betaherpesvirus 5 upregulates a gene that is involved in the positive regulation of cell population proliferation. Evidence for this gene in foreskin fibroblast cell lines (study GSE132081) reports a log2 fold change of 1.336 and an adjusted p-value of 0.004919. Which protein does this gene interact with? | RAB4A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05103","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that is involved in the positive regulation of cell population proliferation. Evi... | |
medium_hidden_intermediate_05104 | Muscle neoplasms can be localized to anatomical structures that are classified as autopod regions. One such structure is described as the distal segment of the forelimb, including the carpal region, metacarpal region, and digits. Which embryonic structure does this specific anatomical entity develop from? | embryonic handplate | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05104","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Muscle neoplasms can be localized to anatomical structures that are classified as autopod regions. One such structure is des... | |
medium_hidden_intermediate_05105 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a specific histone variant that participates in ESR-mediated signaling. This variant exhibits a log2 fold change of approximately 2.31 and an adjusted p-value of 0.0073. Which protein is encoded by this upregulated histone variant? | Histone H2A type 1-J | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05105","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a specific histone variant that part... | |
medium_hidden_intermediate_05107 | In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated and participates in aerobic respiration and respiratory electron transport. Evidence for this gene shows a log2 fold change of approximately 2.13 and an adjusted p-value of 0.0003086. Which biological process is thi... | mitochondrial respiratory chain complex I assembly | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05107","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated and participates in... | |
medium_hidden_intermediate_05109 | A gene is downregulated by Human gammaherpesvirus 8 and participates in the metabolism of proteins. Experimental data for this gene in a non-Hodgkin lymphoma cell line (study GSE119608) reports a log2 fold change of approximately -1.11 and an adjusted p-value of 0.0206. Which disease is associated with this gene as a b... | lung cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05109","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Human gammaherpesvirus 8 and participates in the metabolism of proteins. Experimental data for th... | |
medium_hidden_intermediate_05110 | Zika virus downregulates a gene that is located in the spindle. Evidence for one such gene reports a log2 fold change of -2.096 and an adjusted p-value of 0.02281. Which protein is encoded by that gene? | Spindle and centriole-associated protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05110","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in the spindle. Evidence for one such gene reports a log2 fold change of -2.... | |
medium_hidden_intermediate_05111 | Measles morbillivirus upregulates a gene located in the chromosome telomeric region. Evidence for this specific gene reports a log2 fold change of 1.997 and an adjusted p-value of 0.002456. Which protein is encoded by this gene? | EP300-interacting inhibitor of differentiation 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05111","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene located in the chromosome telomeric region. Evidence for this specific gene reports... | |
medium_hidden_intermediate_05112 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with obesity disorder. One of these genes exhibits a log2 fold change of approximately -1.403 and an adjusted p-value of 0.001386 in a specific study. Which disease is linked to this specific gene through genomic alt... | lung neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05112","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with obesity disorde... | |
medium_hidden_intermediate_05113 | Rift Valley fever phlebovirus infection leads to the upregulation of certain genes whose products are located in the extracellular region. In a study using SAEC cells (GSE102481), one such gene showed a log2 fold change of 2.743 and an adjusted p-value of 0.0372. Which protein is encoded by this specific gene? | Tumor necrosis factor-inducible gene 6 protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05113","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rift Valley fever phlebovirus infection leads to the upregulation of certain genes whose products are located in the extrace... | |
medium_hidden_intermediate_05115 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and binds to MRPL39. Experimental data for this gene reports a log2 fold change of approximately 1.26 and an adjusted p-value of approximately 0.049. Which protein is encoded by this gene? | Large ribosomal subunit protein uL18m | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05115","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and binds to MRPL39. Experimental data for th... | |
medium_hidden_intermediate_05116 | Hepacivirus C upregulates a gene that enables serine-type endopeptidase activity. Evidence for one such gene reports a log2 fold change of 1.141 and an adjusted p-value of 0.006088. Which protein is encoded by that gene? | Peroxisomal leader peptide-processing protease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05116","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that enables serine-type endopeptidase activity. Evidence for one such gene reports a log2 ... | |
medium_hidden_intermediate_05118 | In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and associated with hepatocellular carcinoma. This specific gene exhibits a log2 fold change of approximately 3.47 and an adjusted p-value of 0.017. Which protein is encoded by this gene? | Platelet-derived growth factor receptor-like protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05118","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and associated with hepatocel... | |
medium_hidden_intermediate_05119 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with lung carcinoma. One of these genes exhibits a log2 fold change of -1.972 and an adjusted p-value of 0.01876 in a specific study. Which disease is linked to this specific gene through genomic alterations? | colorectal carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05119","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with lung carcinoma.... | |
medium_hidden_intermediate_05124 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate genes involved in Heparan sulfate/heparin (HS-GAG) metabolism. One such gene exhibited a log2 fold change of 2.131 and an adjusted p-value of 1.531e-07. Which cellular component is this specific gene located in? | membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05124","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate genes involved in H... | |
medium_hidden_intermediate_05125 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes involved in protein ubiquitination. One such gene exhibited a log2 fold change of 1.106 and an adjusted p-value of 9.346e-05. Which protein is encoded by this specific gene? | Melanoma-associated antigen F1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05125","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes ... | |
medium_hidden_intermediate_05126 | Severe acute respiratory syndrome-related coronavirus is linked to cerebral infarction via an intermediate gene that is upregulated by the virus and associated with the condition. One such intermediate gene exhibits a log2 fold change of 3.964 and an adjusted p-value of 0.008454 in a specific study. Which protein is en... | Placenta growth factor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05126","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus is linked to cerebral infarction via an intermediate gene that is upre... | |
medium_hidden_intermediate_05127 | Zika virus downregulates a gene that participates in the metabolism of steroids. Experimental data from glioma stem cells (study GSE114907) indicate that this gene has a log2 fold change of -2.074 and an adjusted p-value of 0.008542. Which protein is encoded by this gene? | Long-chain fatty acid transport protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05127","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in the metabolism of steroids. Experimental data from glioma stem cells (s... | |
medium_hidden_intermediate_05128 | A gene is downregulated by Primate bocaparvovirus 1 and participates in phosphate bond hydrolysis by NUDT proteins. Experimental evidence for this gene shows a log2 fold change of -1.012 and an adjusted p-value of 0.0251. Which protein is encoded by this gene? | 8-oxo-dGDP phosphatase NUDT18 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05128","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and participates in phosphate bond hydrolysis by NUDT proteins. Experime... | |
medium_hidden_intermediate_05129 | Zika virus downregulates a specific gene that is enriched in naive B cells. Experimental data for this gene reports a log2 fold change of -1.356 and an adjusted p-value of 0.009671. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05129","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is enriched in naive B cells. Experimental data for this gene reports a log2 f... | |
medium_hidden_intermediate_05130 | Measles morbillivirus is reported to downregulate a specific gene, which is subsequently found to be enriched in peripheral blood mononuclear cells (PBMCs). Experimental data for this gene in pleural mesothelioma cells indicates a log2 fold change of approximately -2.08 and an adjusted p-value of 0.0007534. Which prote... | Transforming growth factor beta activator LRRC32 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05130","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus is reported to downregulate a specific gene, which is subsequently found to be enriched in peripheral ... | |
medium_hidden_intermediate_05131 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of certain genes that are enriched in natural killer cells. One such gene exhibits a log2 fold change of -1.359 and an adjusted p-value of 0.02615. Which protein is encoded by this specific gene? | Trans-3-hydroxy-L-proline dehydratase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05131","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of certain... | |
medium_hidden_intermediate_05132 | Hepacivirus C is reported to downregulate a gene product that is located in the extracellular space. Experimental data for one such entity indicates a log2 fold change of -2.194 and an adjusted p-value of 0.04274. Which protein is encoded by this specific entity? | Interleukin-27 subunit beta | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05132","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene product that is located in the extracellular space. Experimental data for o... | |
medium_hidden_intermediate_05133 | Two genes are structurally linked from Human immunodeficiency virus 1 to atopic eczema via a downregulation relationship followed by a biomarker association. One of these genes is reported in study GSE108897 (VExD dataset, macrophage cell type) with a log2 fold change of -1.575 and an adjusted p-value of 0.01148. Which... | nucleolus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05133","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Human immunodeficiency virus 1 to atopic eczema via a downregulation relationship fol... | |
medium_hidden_intermediate_05136 | Rhinovirus A is reported to upregulate a gene that is associated with liposarcoma. In a study of cytotoxic T-lymphocytes (GSE106475), one such gene exhibits a log2 fold change of 1.006 and an adjusted p-value of 0.008496. Which protein is encoded by this specific gene? | Acrosin-binding protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05136","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A is reported to upregulate a gene that is associated with liposarcoma. In a study of cytotoxic T-lymphocytes (GS... | |
medium_hidden_intermediate_05137 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene that participates in the KEAP1-NFE2L2 pathway. This gene exhibited a log2 fold change of 3.099 and an adjusted p-value of 7.298e-09. Which protein is encoded by this gene? | 6-phosphogluconate dehydrogenase, decarboxylating | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05137","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_05138 | In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and interacts with RHOA. This specific gene exhibits a log2 fold change of 1.438 and an adjusted p-value of 3.326e-05. Which cellular component is this gene located in? | membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05138","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and interacts with RHOA. This... | |
medium_hidden_intermediate_05139 | PSMA3 is involved in a biological process that is a subtype of T-helper cell differentiation. Evidence for one such process describes it as the process in which a relatively unspecialized T cell acquires the specialized features of a specific T-helper cell subtype, characterized by a CD4-positive, alpha-beta T cell phe... | T-helper 1 cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05139","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"PSMA3 is involved in a biological process that is a subtype of T-helper cell differentiation. Evidence for one such process ... | |
medium_hidden_intermediate_05140 | Two genes are linked to Vaccinia virus via upregulation and to subarachnoid hemorrhage via biomarker association. One of these genes exhibits a log2 fold change of 2.908 and an adjusted p-value of 5.038e-06 in cervical adenocarcinoma cell lines (study GSE11238). Which protein is encoded by this specific gene? | Aldehyde dehydrogenase, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05140","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Vaccinia virus via upregulation and to subarachnoid hemorrhage via biomarker association. One of the... | |
medium_hidden_intermediate_05141 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that is involved in actin cytoskeleton organization. One such gene exhibits a log2 fold change of 1.076 and an adjusted p-value of 0.03145. Which protein is encoded by this specific gene? | Alpha-adducin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05141","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that is involved in actin cytoskele... | |
medium_hidden_intermediate_05142 | In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upregulate a gene that is involved in the positive regulation of microtubule polymerization. Evidence for this specific gene reports a log2 fold change of 1.692 and an adjusted p-value of 0.008213. Whi... | Neuron navigator 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05142","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upreg... | |
medium_hidden_intermediate_05143 | Two genes are linked to preeclampsia via endothelial cell markers. One of these genes is implicated in preeclampsia alongside GPx1, GPx4, SEPS1, Sep15, and TXNRD1, based on evidence stating: 'The totality of the evidence currently implicates GPx1, GPx4, SEPS1, Sep15, a selenoprotein gene and TXNRD1 in conditions such a... | autoimmune thyroid disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05143","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to preeclampsia via endothelial cell markers. One of these genes is implicated in preeclampsia alongsid... | |
medium_hidden_intermediate_05144 | Two genes are downregulated by Zika virus and associated with prostate cancer. One of these genes exhibits a log2 fold change of -1.756 and an adjusted p-value of 0.01153 in glioma stem cells. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05144","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Zika virus and associated with prostate cancer. One of these genes exhibits a log2 fold chang... | |
medium_hidden_intermediate_05145 | Pegivirus C is known to downregulate certain genes, which in turn enable protein-containing complex binding. One such gene exhibits a log2 fold change of -1.490 and an adjusted p-value of 0.0001748 in peripheral blood mononuclear cells (study GSE131504). Which gene is connected to this specific entity through a 'binds'... | SZT2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05145","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is known to downregulate certain genes, which in turn enable protein-containing complex binding. One such gene e... | |
medium_hidden_intermediate_05146 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with HIST1H2BG. Evidence for one such gene reports a log2 fold change of 2.255 and an adjusted p-value of 0.04064. Which protein is encoded by that gene? | Kinesin-like protein KIF20A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05146","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with HIST1H2BG. Evidence for one suc... | |
medium_hidden_intermediate_05148 | A gene is downregulated by Human immunodeficiency virus 1 and enriched in Regulatory T (Treg) cells. Evidence for this gene reports a log2 fold change of -1.551 and an adjusted p-value of 0.007712. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05148","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Human immunodeficiency virus 1 and enriched in Regulatory T (Treg) cells. Evidence for this gene ... | |
medium_hidden_intermediate_05149 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to hepatocellular carcinoma via biomarker association. One of these genes exhibits a log2 fold change of approximately 1.013 and an adjusted p-value of 0.002526 in a specific study. Which protein is encoded by this gene? | Homeobox protein Hox-D10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05149","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to hepatocellular carcino... | |
medium_hidden_intermediate_05152 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Influenza Infection. Evidence for this gene reports a log2 fold change of 1.056 and an adjusted p-value of 0.0109. Which cell type is this gene enriched in? | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05152","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Influenza Infection. Evid... | |
medium_hidden_intermediate_05153 | Two genes are upregulated by Vaccinia virus and associated with congenital heart disease. One of these genes exhibits a log2 fold change of approximately 1.47 and an adjusted p-value of 0.0008979 in cervical adenocarcinoma cell lines (study GSE11238). Which protein is encoded by this specific gene? | Thyrotroph embryonic factor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05153","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and associated with congenital heart disease. One of these genes exhibits a log2... | |
medium_hidden_intermediate_05155 | Zika virus downregulates a gene that interacts with HSPA8. In glioma stem cells, this gene exhibits a log2 fold change of -1.273 and an adjusted p-value of 0.02117. Which protein is encoded by this gene? | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05155","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with HSPA8. In glioma stem cells, this gene exhibits a log2 fold change of -1... | |
medium_hidden_intermediate_05156 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate certain genes that participate in RNA metabolism. One such gene exhibited a log2 fold change of 1.277 and an adjusted p-value of 0.009749. Which protein is encoded by this specific gene? | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05156","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate certain genes that partici... | |
medium_hidden_intermediate_05157 | In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and participates in Signaling by GPCR. Evidence for this gene reports a log2 fold change of approximately 1.135 and an adjusted p-value of 0.04355. Which protein is encoded by this gene? | C-X-C motif chemokine 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05157","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and participate... | |
medium_hidden_intermediate_05158 | Hepacivirus C upregulates a gene that participates in immunoregulatory interactions between a lymphoid and a non-lymphoid cell. Evidence for one such gene reports a log2 fold change of 1.683 and an adjusted p-value of 0.003585. Which disease is connected to that gene through genomic alterations? | tuberculosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05158","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in immunoregulatory interactions between a lymphoid and a non-lymphoid ce... | |
medium_hidden_intermediate_05160 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and participates in transport to the Golgi and subsequent modification. This gene exhibits a log2 fold change of 1.129 and an adjusted p-value of 7.947e-10. Which protein is encoded by this gene? | Protein transport protein Sec24B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05160","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and p... | |
medium_hidden_intermediate_05161 | Human immunodeficiency virus 1 upregulates a gene that enables RNA polymerase II cis-regulatory region sequence-specific DNA binding. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of 2.350 and an adjusted p-value of 0.0008136. Which protein is encoded by this specific gene? | Dachshund homolog 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05161","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that enables RNA polymerase II cis-regulatory region sequence-specific DNA... | |
medium_hidden_intermediate_05162 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to arthritic joint disease via an association relationship. One of these genes was reported in a study (GSE164073) involving sclera cells, with a log2 fold change of approximately 1.403 and an adjusted p-v... | Steroid hormone receptor ERR1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05162","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to arthri... | |
medium_hidden_intermediate_05163 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a gene involved in cilium assembly. This specific gene exhibited a log2 fold change of approximately 3.53 and an adjusted p-value of approximately 8.0e-08. Which cellular component is this gene located in? | centrosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05163","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a gene involved in ... | |
medium_hidden_intermediate_05164 | Two genes are structurally linked to PEX13 via a binding interaction and are localized to the peroxisome. One of these genes is described in the following evidence: 'In addition, we extend the list of peroxins with which human Pex19p interacts to include the PMP Pex16p and show that Pex19p's CaaX prenylation motif is a... | Zellweger spectrum disorders | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05164","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to PEX13 via a binding interaction and are localized to the peroxisome. One of these genes... | |
medium_hidden_intermediate_05165 | Zika virus downregulates a gene that is involved in the response to hypoxia. Evidence for this specific gene reports a log2 fold change of -2.007 and an adjusted p-value of 0.01224. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05165","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the response to hypoxia. Evidence for this specific gene reports a log2 ... | |
medium_hidden_intermediate_05167 | Measles morbillivirus upregulates a gene that is involved in cilium assembly. Evidence for this gene reports a log2 fold change of approximately 3.69 and an adjusted p-value of approximately 0.0186. Which protein does this gene interact with? | TRAF2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05167","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is involved in cilium assembly. Evidence for this gene reports a log2 fold cha... | |
medium_hidden_intermediate_05168 | In a study of bronchial epithelial cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene is downregulated and participates in aerobic respiration and respiratory electron transport. Evidence for this gene reports a log2 fold change of -1.056 and an adjusted p-value of 0.0421. Which ... | Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05168","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of bronchial epithelial cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gen... | |
medium_hidden_intermediate_05169 | Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to the positive regulation of apoptotic process via an 'involved in' relationship. One of these genes exhibits a log2 fold change of -1.568 and an adjusted p-value of 0.005072 in a specific study. Which cell type ... | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05169","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to the positive r... | |
medium_hidden_intermediate_05170 | Two genes are structurally positioned between Pegivirus C and SQSTM1, linked by downregulation from the virus and interaction with SQSTM1. One of these genes exhibits a log2 fold change of -1.890 and an adjusted p-value of 0.02132 in peripheral blood mononuclear cells (study GSE131504). What molecular function is enabl... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05170","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally positioned between Pegivirus C and SQSTM1, linked by downregulation from the virus and interactio... | |
medium_hidden_intermediate_05172 | Human immunodeficiency virus 1 upregulates a gene that enables RNA binding. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of 1.223 and an adjusted p-value of 0.04058. Which protein is encoded by this gene? | Constitutive coactivator of PPAR-gamma-like protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05172","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that enables RNA binding. Evidence for this gene in macrophages (from stud... | |
medium_hidden_intermediate_05173 | A gene is downregulated by Primate bocaparvovirus 1 and is enriched in plasmacytoid dendritic cells. Evidence for this gene reports a log2 fold change of -1.929 and an adjusted p-value of 0.002089. Which cellular component is this gene located in? | autophagosome membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05173","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and is enriched in plasmacytoid dendritic cells. Evidence for this gene ... | |
medium_hidden_intermediate_05174 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the metabolism of vitamins and cofactors. Evidence for this gene reports a log2 fold change of approximately 1.955 and an adjusted p-value of 0.008755. Which biological process is this gene involved in? | nucleotide biosynthetic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05174","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the metabolism of vitamin... | |
medium_hidden_intermediate_05178 | Human polyomavirus 1 upregulates a gene that participates in Metabolism. Evidence for this gene reports a log2 fold change of 1.166 and an adjusted p-value of 0.01. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05178","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human polyomavirus 1 upregulates a gene that participates in Metabolism. Evidence for this gene reports a log2 fold change o... | |
medium_hidden_intermediate_05180 | A gene is upregulated by Human immunodeficiency virus 1 and associated with acidosis disorder. Experimental data for this gene in macrophages reports a log2 fold change of approximately 2.10 and an adjusted p-value of 0.001624. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05180","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human immunodeficiency virus 1 and associated with acidosis disorder. Experimental data for this ge... | |
medium_hidden_intermediate_05181 | Two genes are upregulated by Vaccinia virus and enriched in classical monocytes. One of these genes exhibits a log2 fold change of 2.729 and an adjusted p-value of 0.0001457 in cervical adenocarcinoma cell lines (study GSE11238). Which disease is associated with this specific gene as a biomarker? | lupus vulgaris | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05181","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and enriched in classical monocytes. One of these genes exhibits a log2 fold cha... | |
medium_hidden_intermediate_05183 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (SARS-CoV-2), gene expression analysis identified a specific gene that is downregulated by the virus and whose product is located in the actin cytoskeleton. This gene exhibited a log2 fold change of -2.059 and an adjusted p-val... | Chronophin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05183","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (SARS-CoV-2), gene expression a... | |
medium_hidden_intermediate_05184 | A gene is upregulated by Human gammaherpesvirus 8 and is associated with carcinoma. Experimental data for this gene reports a log2 fold change of 1.676 and an adjusted p-value of 0.01636. Which protein is encoded by this gene? | Killer cell lectin-like receptor subfamily G member 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05184","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human gammaherpesvirus 8 and is associated with carcinoma. Experimental data for this gene reports ... | |
medium_hidden_intermediate_05185 | Human betaherpesvirus 5 is reported to downregulate a gene that participates in the metabolism of carbohydrates and carbohydrate derivatives. Experimental data for one such gene in foreskin fibroblast cell lines shows a log2 fold change of -1.121 and an adjusted p-value of 0.0002162. Which protein is encoded by this sp... | Hyaluronidase-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05185","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that participates in the metabolism of carbohydrates and carbohyd... | |
medium_hidden_intermediate_05186 | Pegivirus C downregulates a gene that enables G protein activity. In a study of peripheral blood mononuclear cells (GSE131504), one such gene showed a log2 fold change of -1.723 and an adjusted p-value of 0.0001203. Which protein is encoded by this gene? | Ras-related protein Rab-39A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05186","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that enables G protein activity. In a study of peripheral blood mononuclear cells (GSE13150... | |
medium_hidden_intermediate_05187 | Pegivirus C is reported to downregulate a gene that is involved in the cellular response to cholesterol. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.339 and an adjusted p-value of 0.01463. Which protein is encoded by this specific gene? | Endoplasmic reticulum membrane sensor NFE2L1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05187","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in the cellular response to cholesterol. In a study of perip... | |
medium_hidden_intermediate_05188 | Severe acute respiratory syndrome-related coronavirus downregulates a specific gene, which in turn interacts with GSK3B. Experimental data for this gene in lung tissue shows a log2 fold change of -1.090 and an adjusted p-value of 0.0001531. Which protein is encoded by this gene? | Endosome-associated-trafficking regulator 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05188","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a specific gene, which in turn interacts with GSK3B. Exp... | |
medium_hidden_intermediate_05189 | Zika virus downregulates a gene that enables histone H3K27me3 reader activity. In glioma stem cells, one such gene exhibits a log2 fold change of -1.699 and an adjusted p-value of 0.002695. Which protein is encoded by this gene? | Hepatoma-derived growth factor-related protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05189","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that enables histone H3K27me3 reader activity. In glioma stem cells, one such gene exhibits ... | |
medium_hidden_intermediate_05190 | Two genes are upregulated by Enterovirus A and participate in Glycerophospholipid biosynthesis. One of these genes shows a log2 fold change of approximately 1.057 and an adjusted p-value of 0.04484 in rhabdomyosarcoma cells. Which cell type is enriched for this specific gene? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05190","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Enterovirus A and participate in Glycerophospholipid biosynthesis. One of these genes shows a l... | |
medium_hidden_intermediate_05191 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is associated with lung carcinoma. Experimental data for this gene reports a log2 fold change of -1.198 and an adjusted p-value of 0.001009. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05191","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is associated with lung carcinoma. Expe... | |
medium_hidden_intermediate_05192 | Two genes are each downregulated by Human immunodeficiency virus 1 and associated with benign neoplasm. One of these genes exhibits a log2 fold change of approximately -1.447 and an adjusted p-value of 0.002801 in macrophages (study GSE108897). Which gene interacts with the gene identified by these statistical values? | MICB | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05192","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each downregulated by Human immunodeficiency virus 1 and associated with benign neoplasm. One of these genes e... | |
medium_hidden_intermediate_05193 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene located in the perinuclear region of the cytoplasm. This gene exhibited a log2 fold change of approximately 2.21 and an adjusted p-value of 0.007871. Which protein is encoded by this gene? | Ankyrin repeat domain-containing protein 13B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05193","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... |
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