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medium_hidden_intermediate_05194 | Human immunodeficiency virus 1 upregulates a gene that enables transcription coactivator activity. In a study of macrophages (GSE108897), one such gene showed a log2 fold change of 2.820 and an adjusted p-value of 0.005731. Which disease is associated with this gene as a biomarker? | kidney Wilms tumor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05194","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that enables transcription coactivator activity. In a study of macrophages... | |
medium_hidden_intermediate_05195 | Human alphaherpesvirus 1 upregulates a gene that is involved in mitotic DNA replication checkpoint signaling. In a study of monocytic leukemia cell lines (GSE114966), one such gene showed a log2 fold change of approximately 2.365 and an adjusted p-value of 0.003552. Which protein is encoded by this specific gene? | Protein downstream neighbor of Son | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05195","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that is involved in mitotic DNA replication checkpoint signaling. In a study of ... | |
medium_hidden_intermediate_05196 | Human immunodeficiency virus 1 downregulates a gene that enables GTP binding. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of -1.095 and an adjusted p-value of 0.003656. Which biological process is this gene involved in? | protein import into nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05196","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that enables GTP binding. In a study of macrophages (GSE108897), one suc... | |
medium_hidden_intermediate_05197 | A gene serves as a marker for oogenesis phase fetal germ cells and is enriched in natural killer cells. Evidence for one such gene reports a mean expression of 155.80 TPM, a z-score of 2.96, and a fold enrichment of 42.18. Which biological process is this gene involved in? | spermatid development | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05197","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for oogenesis phase fetal germ cells and is enriched in natural killer cells. Evidence for one suc... | |
medium_hidden_intermediate_05198 | Human betaherpesvirus 5 is reported to downregulate a gene that is involved in signal transduction. In a study of foreskin fibroblast cell lines (GSE111036), one such gene exhibited a log2 fold change of -1.249 and an adjusted p-value of 0.04714. Which protein is encoded by this specific gene? | Secretion-regulating guanine nucleotide exchange factor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05198","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that is involved in signal transduction. In a study of foreskin f... | |
medium_hidden_intermediate_05199 | Human orthopneumovirus infection leads to the upregulation of specific genes that participate in post-translational protein modification. One such gene exhibits a log2 fold change of approximately 1.39 and an adjusted p-value of 0.04834 in cytotoxic T-lymphocytes. In which cell type is this specific gene enriched? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05199","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human orthopneumovirus infection leads to the upregulation of specific genes that participate in post-translational protein ... | |
medium_hidden_intermediate_05201 | Pegivirus C is reported to downregulate a specific gene, which in turn participates in the biological process 'Amino acids regulate mTORC1'. Transcriptomic data from peripheral blood mononuclear cells (study GSE131504) indicates that this gene has a log2 fold change of approximately -1.51 and an adjusted p-value of 0.0... | V-type proton ATPase subunit B, brain isoform | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05201","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn participates in the biological process 'Amino acids r... | |
medium_hidden_intermediate_05202 | Zika virus downregulates a specific gene that enables DNA binding. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -1.144 and an adjusted p-value of 0.01724. Which disease is associated with this gene? | alveolar rhabdomyosarcoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05202","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that enables DNA binding. In a study of glioma stem cells (GSE114907), this gene ex... | |
medium_hidden_intermediate_05203 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes located in focal adhesions. One such gene exhibits a log2 fold change of -1.672 and an adjusted p-value of 0.0003205. Which protein is encoded by this specific gene? | Ras suppressor protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05203","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes locat... | |
medium_hidden_intermediate_05204 | Human alphaherpesvirus 3 is known to downregulate multiple genes that are located in the nucleus. One such gene exhibits a log2 fold change of approximately -1.108 and an adjusted p-value of 2.462e-06 in a melanoma cell line study (GSE136586). Which protein is encoded by this specific gene? | DCC-interacting protein 13-beta | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05204","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 is known to downregulate multiple genes that are located in the nucleus. One such gene exhibits a l... | |
medium_hidden_intermediate_05205 | Two genes are upregulated by Vaccinia virus and participate in Glycerophospholipid biosynthesis. One of these genes exhibits a log2 fold change of 2.842 and an adjusted p-value of 5.599e-13 in cervical adenocarcinoma cell lines. Which disease is associated with this specific gene? | trophoblastic neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05205","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and participate in Glycerophospholipid biosynthesis. One of these genes exhibits... | |
medium_hidden_intermediate_05207 | Human immunodeficiency virus 1 downregulates a specific gene, which in turn participates in disease pathology. Experimental data from a study on macrophages (GSE108897) indicates that this gene has a log2 fold change of approximately -1.307 and an adjusted p-value of 0.00972. Which biological process is this gene invol... | protein complex oligomerization | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05207","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a specific gene, which in turn participates in disease pathology. Experimental ... | |
medium_hidden_intermediate_05208 | Hepacivirus C downregulates a gene that enables metallocarboxypeptidase activity. In a study of hepatocytes (GSE132606), one such gene exhibits a log2 fold change of approximately -1.73 and an adjusted p-value of 0.0035. Which protein is encoded by this specific gene? | Tubulinyl-Tyr carboxypeptidase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05208","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a gene that enables metallocarboxypeptidase activity. In a study of hepatocytes (GSE132606), one... | |
medium_hidden_intermediate_05209 | Two genes are downregulated by Human immunodeficiency virus 1 and are involved in the positive regulation of canonical NF-kappaB signal transduction. One of these genes exhibits a log2 fold change of approximately -1.14 and an adjusted p-value of 0.001951 in macrophages. Which cell type is enriched for this specific ge... | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05209","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Human immunodeficiency virus 1 and are involved in the positive regulation of canonical NF-ka... | |
medium_hidden_intermediate_05210 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with PTPRO. One of these genes exhibits a log2 fold change of 1.468 and an adjusted p-value of 7.265e-06 in liver cells. Which biological process is this specific gene involved in? | protein refolding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05210","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with PTPRO. One of these gen... | |
medium_hidden_intermediate_05211 | Zika virus downregulates a specific gene, which in turn participates in diseases associated with O-glycosylation of proteins. Experimental data from glioma stem cells (study GSE114907) indicates that this gene has a log2 fold change of -1.737 and an adjusted p-value of 0.006821. Which disease is associated with this ge... | aortic aneurysm, familial thoracic 12 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05211","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn participates in diseases associated with O-glycosylation of proteins... | |
medium_hidden_intermediate_05212 | Two genes are linked to Measles morbillivirus via upregulation and to bipolar disorder via biomarker association. One of these genes is reported in study GSE131840 with a log2 fold change of approximately 6.58 and an adjusted p-value of approximately 0.0166. Which protein does this specific gene interact with? | UBE2I | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05212","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Measles morbillivirus via upregulation and to bipolar disorder via biomarker association. One of the... | |
medium_hidden_intermediate_05213 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a specific gene that subsequently interacts with CUL3. This gene exhibited a log2 fold change of approximately 1.535 and an adjusted p-value of 2.451e-08. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05213","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a specific gene tha... | |
medium_hidden_intermediate_05214 | Human alphaherpesvirus 3 is known to downregulate certain genes whose products are located in the membrane. In a study of melanoma cell lines (GSE136586), one such gene exhibited a log2 fold change of -1.225 and an adjusted p-value of 1.975e-05. Which protein is encoded by this specific gene? | Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05214","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 is known to downregulate certain genes whose products are located in the membrane. In a study of me... | |
medium_hidden_intermediate_05215 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with PPP2CB. One of these genes was reported in a study of choroid plexus epithelium (GSE157852) with a log2 fold change of approximately 1.078 and an adjusted p-value of 0.002348. Which protein is encoded by this specific g... | MOB-like protein phocein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05215","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with PPP2CB. One of these ge... | |
medium_hidden_intermediate_05216 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is downregulated and participates in Azathioprine ADME. This gene exhibits a log2 fold change of approximately -1.26 and an adjusted p-value of 4.505e-06. Which cellular component is this gene located in? | mitochondrion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05216","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is downregulated and... | |
medium_hidden_intermediate_05219 | Zika virus downregulates a specific gene that interacts with UBC. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -2.895 and an adjusted p-value of 0.003561. In which cell type is this gene enriched? | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05219","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that interacts with UBC. Experimental data for this gene in glioma stem cells (stud... | |
medium_hidden_intermediate_05220 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a specific histone H2B variant, which in turn participates in the process where HDACs deacetylate histones. Evidence for this specific variant reports a log2 fold change of 1.912 and an adjusted p-value of 0.003289. Which protein is... | Histone H2B type 1-L | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05220","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a specific histone H2B variant, whic... | |
medium_hidden_intermediate_05223 | A gene is upregulated by Human immunodeficiency virus 1 and enables receptor ligand activity. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of 2.328 and an adjusted p-value of 0.03485. Which disease is associated with this gene through genomic alterations? | multiple sclerosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05223","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human immunodeficiency virus 1 and enables receptor ligand activity. Evidence for this gene in macr... | |
medium_hidden_intermediate_05224 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in the Cell Cycle. Experimental data for this gene reports a log2 fold change of -2.754 and an adjusted p-value of 0.01842. Which cellular component is this gene located in? | microtubule organizing center | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05224","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in the Cell Cycle. Experim... | |
medium_hidden_intermediate_05225 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the response to virus. Evidence for one such gene reports a log2 fold change of approximately 1.064 and an adjusted p-value of approximately 0.0009971. Which cell type is that gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05225","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the response to virus. Evidence... | |
medium_hidden_intermediate_05226 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Signaling by Receptor Tyrosine Kinases. Experimental evidence for this gene reports a log2 fold change of 1.800 and an adjusted p-value of 0.01466. Which protein is encoded by this gene? | Kunitz-type protease inhibitor 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05226","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Signaling by Receptor Tyr... | |
medium_hidden_intermediate_05227 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by the virus and participates in the Cell Cycle. This gene exhibits a log2 fold change of 1.694 and an adjusted p-value of 3.602e-08. Which protein is encoded by this gene? | Serine/threonine-protein kinase Nek7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05227","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by th... | |
medium_hidden_intermediate_05228 | EP300 interacts with a protein that is located in the cytoplasm. Evidence indicates that this protein is stably associated with RNA polymerase II and the coactivator p300 on the endogenous MDR1 promoter. Which protein is encoded by the gene corresponding to this entity? | DNA repair nuclease/redox regulator APEX1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05228","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"EP300 interacts with a protein that is located in the cytoplasm. Evidence indicates that this protein is stably associated w... | |
medium_hidden_intermediate_05229 | Zika virus downregulates multiple genes that participate in the biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and its transfer to a nascent protein. One such gene exhibits a log2 fold change of approximately -1.78 and an adjusted p-value of 0.0139 in glioma stem cells. Which protei... | BAG3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05229","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates multiple genes that participate in the biosynthesis of the N-glycan precursor (dolichol lipid-linke... | |
medium_hidden_intermediate_05230 | Cardiovirus A upregulates a gene that is involved in chemotaxis. Experimental data from a study on cervical adenocarcinoma cell lines (GSE122967) reports a log2 fold change of 1.025 and an adjusted p-value of 0.03384 for this gene. Which protein is encoded by this gene? | C-X-C motif chemokine 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05230","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A upregulates a gene that is involved in chemotaxis. Experimental data from a study on cervical adenocarcinoma c... | |
medium_hidden_intermediate_05231 | Human alphaherpesvirus 1 upregulates a gene that participates in the metabolism of lipids. Evidence for this gene reports a log2 fold change of 1.082 and an adjusted p-value of 0.006679. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05231","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that participates in the metabolism of lipids. Evidence for this gene reports a ... | |
medium_hidden_intermediate_05232 | Two genes are each downregulated by Human betaherpesvirus 5 and associated with gastric cancer. One of these genes exhibits a log2 fold change of approximately -1.64 and an adjusted p-value of 0.0494 in a specific study. Which cell type is enriched for this specific gene? | classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05232","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each downregulated by Human betaherpesvirus 5 and associated with gastric cancer. One of these genes exhibits ... | |
medium_hidden_intermediate_05233 | A gene is downregulated by Primate bocaparvovirus 1 and is involved in cell population proliferation. Experimental data for this gene in vascular endothelial cells from study GSE16354 shows a log2 fold change of -2.762 and an adjusted p-value of 0.0003118. Which disease is associated with this gene as a biomarker? | pneumonia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05233","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and is involved in cell population proliferation. Experimental data for ... | |
medium_hidden_intermediate_05235 | YWHAG interacts with a gene that is enriched in neutrophils. Evidence for this gene includes a mean expression of 61.17 TPM, a z-score of 2.72, and a fold enrichment of 6.48. Which gene interacts with this identified gene? | MTMR4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05235","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"YWHAG interacts with a gene that is enriched in neutrophils. Evidence for this gene includes a mean expression of 61.17 TPM,... | |
medium_hidden_intermediate_05236 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes involved in endoplasmic reticulum to Golgi vesicle-mediated transport. One such gene exhibited a log2 fold change of approximately 1.065 and an adjusted p-value of 0.006773. Which protein is enco... | Protein cornichon homolog 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05236","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes... | |
medium_hidden_intermediate_05237 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in lipid transport. Evidence for this gene reports a log2 fold change of 1.368 and an adjusted p-value of 0.04515. Which cell type is this gene enriched in? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05237","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in lipid transport. Evidence ... | |
medium_hidden_intermediate_05238 | In the choroid plexus epithelium, Severe acute respiratory syndrome-related coronavirus downregulates a specific gene, which in turn binds to RFC5. Evidence for this gene reports a log2 fold change of -1.456 and an adjusted p-value of 0.01697. Which protein is encoded by this gene? | DNA polymerase alpha subunit B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05238","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In the choroid plexus epithelium, Severe acute respiratory syndrome-related coronavirus downregulates a specific gene, which... | |
medium_hidden_intermediate_05240 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which in turn interacts with HSPA4. Evidence for this intermediate gene reports a log2 fold change of -1.271 and an adjusted p-value of 0.009426. Which protein is encoded by this interme... | Heat shock 70 kDa protein 4L | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05240","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_05243 | Zika virus downregulates a specific gene, and the protein product of that gene interacts with VPS29. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -1.105 and an adjusted p-value of 0.02543. Which protein is encoded by this gene? | DENN domain-containing protein 10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05243","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, and the protein product of that gene interacts with VPS29. In a study of glioma st... | |
medium_hidden_intermediate_05245 | Zika virus downregulates a specific gene that subsequently binds to UBC. Experimental data for this gene in glioma stem cells (from study GSE114907) reports a log2 fold change of approximately -1.55 and an adjusted p-value of approximately 0.0387. In which cell type is this gene reported to be enriched? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05245","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that subsequently binds to UBC. Experimental data for this gene in glioma stem cell... | |
medium_hidden_intermediate_05246 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with RBM19. One of these genes shows a log2 fold change of approximately 1.275 and an adjusted p-value of 0.00884 in a specific study. Which protein is encoded by this gene? | Nucleolar protein 9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05246","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with RBM19. One of these gen... | |
medium_hidden_intermediate_05247 | PRKN interacts with a protein that is located in the mitochondrial matrix. Evidence indicates that this protein, identified as the 4-Nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1, accumulates on the mitochondria surface upon mitochondrial depolarization. Which biological process is this p... | mitophagy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05247","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"PRKN interacts with a protein that is located in the mitochondrial matrix. Evidence indicates that this protein, identified ... | |
medium_hidden_intermediate_05250 | Two genes are upregulated by Influenza A virus and enriched in non-classical monocytes. One of these genes exhibits a log2 fold change of 1.015 and an adjusted p-value of 0.009509 in a specific study. Which disease is associated with this specific gene? | diabetes mellitus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05250","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Influenza A virus and enriched in non-classical monocytes. One of these genes exhibits a log2 f... | |
medium_hidden_intermediate_05251 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are located in the focal adhesion. One of these genes exhibits a log2 fold change of -1.515 and an adjusted p-value of 0.01441 in lung cells. Which protein interacts with this specific gene? | CBL | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05251","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are located in the focal adhesion. ... | |
medium_hidden_intermediate_05252 | Two genes are upregulated by Hepacivirus C and enriched in non-classical monocytes. One of these genes has a reported log2 fold change of 1.230 and an adjusted p-value of 0.001806. Which disease is associated with genomic alterations in this specific gene? | arteriosclerosis disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05252","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Hepacivirus C and enriched in non-classical monocytes. One of these genes has a reported log2 f... | |
medium_hidden_intermediate_05254 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that is located in the peroxisome. One such gene exhibited a log2 fold change of approximately -4.13 and an adjusted p-value of 0.017. Which protein is encoded by this specific gene? | Peroxisomal succinyl-coenzyme A thioesterase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05254","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that is located in th... | |
medium_hidden_intermediate_05255 | Pegivirus C is reported to downregulate a gene that is involved in intracellular protein transport. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -2.310 and an adjusted p-value of 0.03112. Which protein is encoded by this specific gene? | Mitochondrial import inner membrane translocase subunit Tim21 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05255","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in intracellular protein transport. In a study of peripheral... | |
medium_hidden_intermediate_05256 | Zika virus downregulates a specific gene, which in turn interacts with RQCD1. Transcriptomic data from glioma stem cells (study GSE114907) indicates that this gene has a log2 fold change of approximately -2.405 and an adjusted p-value of 0.005615. Which protein is encoded by this gene? | Transmembrane protein 131 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05256","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with RQCD1. Transcriptomic data from glioma stem cells (st... | |
medium_hidden_intermediate_05258 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Fatty acid metabolism. One of these genes exhibits a log2 fold change of approximately 1.315 and an adjusted p-value of 0.01595 in sclera cells. Which cellular component is the location of this specific gene? | endoplasmic reticulum | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05258","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Fatty acid metabolism.... | |
medium_hidden_intermediate_05259 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by the virus and its product enables ATP binding. This gene exhibits a log2 fold change of 1.013 and an adjusted p-value of 1.803e-06. What is the name of the protein encoded by this gene? | NEDD4-binding protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05259","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by th... | |
medium_hidden_intermediate_05260 | GDI1 interacts with a small GTPase protein that regulates the motility and fusion of early endosomes, interacts with LRRK2, and co-regulates synaptic vesicle endocytosis. This protein also enables protein binding. Which protein is encoded by the gene corresponding to this entity? | Ras-related protein Rab-5B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05260","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"GDI1 interacts with a small GTPase protein that regulates the motility and fusion of early endosomes, interacts with LRRK2, ... | |
medium_hidden_intermediate_05261 | Human alphaherpesvirus 1 downregulates a gene that is located in the cytoplasm. Evidence for one such gene reports a log2 fold change of -1.406 and an adjusted p-value of 0.003552. Which disease is associated with this gene as a biomarker? | prostate cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05261","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 downregulates a gene that is located in the cytoplasm. Evidence for one such gene reports a log2 fo... | |
medium_hidden_intermediate_05262 | Pegivirus C is reported to downregulate a gene that participates in Rab regulation of trafficking. In a study of peripheral blood mononuclear cells (GSE131504), one such gene showed a log2 fold change of -1.097 and an adjusted p-value of 0.03998. Which protein is encoded by this gene? | Ras-related protein Rab-5B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05262","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that participates in Rab regulation of trafficking. In a study of peripheral ... | |
medium_hidden_intermediate_05263 | A gene is downregulated by Vaccinia virus and located in the extracellular space. Transcriptomic data for this gene in cervical adenocarcinoma cells (study GSE11238) shows a log2 fold change of -2.744 and an adjusted p-value of 0.02165. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05263","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Vaccinia virus and located in the extracellular space. Transcriptomic data for this gene in cervi... | |
medium_hidden_intermediate_05264 | In a study of Measles morbillivirus infection, a specific gene is downregulated by the virus and its expression is enriched in basophils. Evidence for this gene reports a log2 fold change of -1.023 and an adjusted p-value of 0.01985. Which protein is encoded by this gene? | PRELI domain-containing protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05264","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is downregulated by the virus and its expression is enriched ... | |
medium_hidden_intermediate_05265 | Human betaherpesvirus 5 upregulates a gene that enables identical protein binding. Experimental data for this gene reports a log2 fold change of 5.991 and an adjusted p-value of 0.01403. Which protein is encoded by this gene? | Interferon-induced protein with tetratricopeptide repeats 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05265","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that enables identical protein binding. Experimental data for this gene reports a... | |
medium_hidden_intermediate_05267 | Measles morbillivirus upregulates a gene that interacts with SEC62. Evidence for one such gene reports a log2 fold change of 2.245 and an adjusted p-value of 0.01738. Which cellular component is that gene located in? | membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05267","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that interacts with SEC62. Evidence for one such gene reports a log2 fold change of... | |
medium_hidden_intermediate_05268 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and located in the Golgi membrane. Evidence for this gene reports a log2 fold change of -1.380 and an adjusted p-value of 0.00259. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05268","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and located in the Golgi membrane. Evidence... | |
medium_hidden_intermediate_05269 | A gene is downregulated by Primate bocaparvovirus 1 and participates in the transport of small molecules. Experimental evidence for this gene reports a log2 fold change of -1.582 and an adjusted p-value of 0.02578. Which cellular component is this gene located in? | microvillus membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05269","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and participates in the transport of small molecules. Experimental evide... | |
medium_hidden_intermediate_05270 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and involved in translation was found to have a log2 fold change of 3.342 and an adjusted p-value of 5.41e-10. Which protein does this specific gene product bind to? | SPCS3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05270","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and involved in translatio... | |
medium_hidden_intermediate_05271 | Two genes are each downregulated by Hepacivirus C and associated with neuroblastoma. One of these genes exhibits a log2 fold change of -2.135 and an adjusted p-value of 0.0001481 in peripheral blood mononuclear cells. Which gene binds to the target associated with this specific expression profile? | RET | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05271","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each downregulated by Hepacivirus C and associated with neuroblastoma. One of these genes exhibits a log2 fold... | |
medium_hidden_intermediate_05274 | In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), a gene upregulated by Influenza A virus and enabling DNA-binding transcription factor activity was found to have a log2 fold change of approximately 1.026 and an adjusted p-value of 2.235e-05. Which disease is associated with genomic alterations i... | oral cavity carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05274","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), a gene upregulated by Influenza A virus and enablin... | |
medium_hidden_intermediate_05277 | A gene is upregulated by Human gammaherpesvirus 8 and enriched in neutrophils. Evidence for this gene in a non-Hodgkin lymphoma cell line (study GSE119608) reports a log2 fold change of 3.525 and an adjusted p-value of 0.002692. Which cellular component is this gene located in? | extracellular space | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05277","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human gammaherpesvirus 8 and enriched in neutrophils. Evidence for this gene in a non-Hodgkin lymph... | |
medium_hidden_intermediate_05278 | GNA15 interacts with a protein that is localized to the nucleus. Experimental evidence indicates that a GFP-tagged version of this protein localizes to the nucleus, plasma membrane, and cytoplasm of HEK293 cells. Which disease is associated with this protein? | lymphoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05278","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"GNA15 interacts with a protein that is localized to the nucleus. Experimental evidence indicates that a GFP-tagged version o... | |
medium_hidden_intermediate_05279 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Cellular responses to stimuli. Experimental data for this gene in lung cells (study GSE148697) show a log2 fold change of approximately -1.04 and an adjusted p-value of approximately 0.0099. Which biological process is ... | cellular response to interleukin-4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05279","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Cellular responses to s... | |
medium_hidden_intermediate_05282 | Human respirovirus 3 upregulates a gene that enables protein binding. In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), this gene exhibited a log2 fold change of approximately 1.52 and an adjusted p-value of 0.042. Which cellular component is this gene located in? | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05282","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human respirovirus 3 upregulates a gene that enables protein binding. In a study of non-small cell lung adenocarcinoma cell ... | |
medium_hidden_intermediate_05283 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables protein disulfide isomerase activity. Evidence for this gene reports a log2 fold change of 2.539 and an adjusted p-value of 3.744e-06. Which cellular component is this gene located in? | endoplasmic reticulum | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05283","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables protein disulfide isomerase activ... | |
medium_hidden_intermediate_05284 | Two genes are upregulated by Human immunodeficiency virus 1 and enriched in classical monocytes. One of these genes exhibits a log2 fold change of approximately 5.33 and an adjusted p-value of approximately 0.008 in macrophages. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05284","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and enriched in classical monocytes. One of these genes exhibits... | |
medium_hidden_intermediate_05285 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is located in the chromosome, telomeric region. Evidence for this gene reports a log2 fold change of 2.817 and an adjusted p-value of 0.02786. Which disease is associated with this gene as a biomarker? | adult glioblastoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05285","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is located in the chromosome, telomeric r... | |
medium_hidden_intermediate_05286 | Zika virus downregulates a gene that enables K48-linked polyubiquitin modification-dependent protein binding. In a study of glioma stem cells (GSE114907), one such gene exhibits a log2 fold change of -1.345 and an adjusted p-value of 0.01938. Which protein is encoded by this gene? | Ubiquitin carboxyl-terminal hydrolase MINDY-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05286","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that enables K48-linked polyubiquitin modification-dependent protein binding. In a study of ... | |
medium_hidden_intermediate_05287 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by the virus and its protein product interacts with PTK2. This gene exhibits a log2 fold change of approximately 1.084 and an adjusted p-value of 0.0003387. Which protein is encoded by this gene? | Enhancer of filamentation 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05287","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by th... | |
medium_hidden_intermediate_05288 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of a specific gene, which in turn interacts with CD274. This gene exhibits a log2 fold change of 1.444 and an adjusted p-value of 0.002787. Which protein is encoded by this gene? | Exportin-7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05288","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of a specific gene, whic... | |
medium_hidden_intermediate_05289 | Two genes are structurally linked from Human immunodeficiency virus 1 via a 'downregulates' relationship and onward to the 'Response of EIF2AK1 (HRI) to heme deficiency' via a 'participates in' relationship. One of these genes exhibits a log2 fold change of approximately -3.07 and an adjusted p-value of 0.0091 in macro... | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05289","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Human immunodeficiency virus 1 via a 'downregulates' relationship and onward to the '... | |
medium_hidden_intermediate_05290 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are enriched in Naive CD8+ T cells. One of these genes exhibits a log2 fold change of -1.897 and an adjusted p-value of 7.86e-06 in a specific study. Which protein is encoded by this gene? | Equilibrative nucleoside transporter 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05290","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are enriched in Naive CD8+ T cells.... | |
medium_hidden_intermediate_05291 | In a study of cervical adenocarcinoma cell lines (GSE11238), a specific gene is upregulated by Vaccinia virus and is involved in the negative regulation of the apoptotic process. This gene exhibits a log2 fold change of 2.092 and an adjusted p-value of 0.0002312. Which protein is encoded by this gene? | Nuclear GTPase SLIP-GC | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05291","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a specific gene is upregulated by Vaccinia virus and is involve... | |
medium_hidden_intermediate_05292 | Hepacivirus C is reported to downregulate a specific gene, which is in turn associated with gastric cancer. Experimental data for this gene in peripheral blood mononuclear cells (from study GSE119117) indicate a log2 fold change of approximately -3.43 and an adjusted p-value of approximately 0.0224. Which protein is en... | Urocortin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05292","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a specific gene, which is in turn associated with gastric cancer. Experimental dat... | |
medium_hidden_intermediate_05293 | Vaccinia virus upregulates a gene that enables mRNA binding. Evidence for this gene in a cervical adenocarcinoma cell line reports a log2 fold change of 2.018 and an adjusted p-value of 1.852e-05. Which cell type is this gene enriched in? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05293","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a gene that enables mRNA binding. Evidence for this gene in a cervical adenocarcinoma cell line r... | |
medium_hidden_intermediate_05294 | Human betaherpesvirus 5 is reported to downregulate a specific gene, which in turn interacts with GOLPH3. In a study of foreskin fibroblast cell lines (GSE111036), this intermediate gene exhibited a log2 fold change of approximately -1.199 and an adjusted p-value of 0.04256. Which protein is encoded by this intermediat... | Divergent protein kinase domain 2A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05294","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a specific gene, which in turn interacts with GOLPH3. In a study of fore... | |
medium_hidden_intermediate_05296 | Cardiovirus A infection leads to the upregulation of specific genes that enable cytokine activity. In a study of cervical adenocarcinoma cell lines (GSE122967), one such upregulated gene exhibited a log2 fold change of 2.220 and an adjusted p-value of 0.02701. Which protein is encoded by this specific gene? | Leukemia inhibitory factor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05296","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A infection leads to the upregulation of specific genes that enable cytokine activity. In a study of cervical ad... | |
medium_hidden_intermediate_05297 | Two genes are structurally linked from Hepacivirus C via a downregulation relationship and subsequently to Classical monocyte via an enrichment relationship. One of these genes is reported in a study (GSE119117) with a log2 fold change of -1.030 and an adjusted p-value of 0.0001573. Which disease is associated with thi... | alcoholic liver cirrhosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05297","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Hepacivirus C via a downregulation relationship and subsequently to Classical monocyt... | |
medium_hidden_intermediate_05300 | Two genes are structurally linked from Hepacivirus C via a 'downregulates' relationship and subsequently to Regulatory T (Treg) cells via an 'enriched in' relationship. One of these genes is associated with a log2 fold change of -1.510 and an adjusted p-value of 7.344e-10 in hepatocytes. Which disease is connected to t... | non-small cell lung carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05300","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Hepacivirus C via a 'downregulates' relationship and subsequently to Regulatory T (Tr... | |
medium_hidden_intermediate_05302 | Human immunodeficiency virus 1 upregulates a gene that is located in the recycling endosome. Evidence for this gene in macrophages (study GSE108897) reports a log2 fold change of 1.493 and an adjusted p-value of 9.345e-05. Which protein is encoded by this gene? | Ras-related protein Rab-29 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05302","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is located in the recycling endosome. Evidence for this gene in macro... | |
medium_hidden_intermediate_05304 | In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection was found to upregulate certain genes that are enriched in conventional dendritic cells. One such gene exhibited a log2 fold change of 1.020 and an adjusted p-value of 7.126e-06. Which protein is encoded by this specifi... | Protein Smaug homolog 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05304","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection was found to upregulate... | |
medium_hidden_intermediate_05305 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with SRPK2. Experimental data for this gene reports a log2 fold change of 1.322 and an adjusted p-value of 0.006858. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05305","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with SRPK2. Experimental data f... | |
medium_hidden_intermediate_05307 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is associated with hypersensitivity reaction disease. Experimental data for this gene reports a log2 fold change of -2.823 and an adjusted p-value of 0.008407. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05307","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is associated with hypersensitivity rea... | |
medium_hidden_intermediate_05308 | Two genes are each upregulated by Vaccinia virus and associated with glioma. One of these genes exhibits a log2 fold change of 1.868 and an adjusted p-value of 4.695e-05 in cervical adenocarcinoma cell lines (study GSE11238). Which protein interacts with this specific gene? | RAF1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05308","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each upregulated by Vaccinia virus and associated with glioma. One of these genes exhibits a log2 fold change ... | |
medium_hidden_intermediate_05309 | Human alphaherpesvirus 1 upregulates a gene that is enriched in regulatory T (Treg) cells. Evidence for one such gene reports a log2 fold change of 2.073 and an adjusted p-value of 0.002731. Which biological process is this gene involved in? | regulation of cell population proliferation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05309","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that is enriched in regulatory T (Treg) cells. Evidence for one such gene report... | |
medium_hidden_intermediate_05310 | Two genes are structurally linked to Measles morbillivirus via an 'upregulates' relationship and to Naive CD8+ T cells via an 'enriched in' relationship. One of these genes is associated with experimental data showing a log2 fold change of approximately 1.501 and an adjusted p-value of 0.007644. Which protein is encode... | Equilibrative nucleoside transporter 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05310","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Measles morbillivirus via an 'upregulates' relationship and to Naive CD8+ T cells via a... | |
medium_hidden_intermediate_05311 | Human alphaherpesvirus 1 upregulates a gene that participates in post-translational protein modification. In a study of monocytic leukemia cell lines (GSE114966), one such upregulated gene showed a log2 fold change of 2.824 and an adjusted p-value of 0.004963. Which protein is encoded by this specific gene? | Histone H2A type 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05311","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that participates in post-translational protein modification. In a study of mono... | |
medium_hidden_intermediate_05312 | Pegivirus C is reported to downregulate a gene that participates in programmed cell death. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -1.76 and an adjusted p-value of 0.0053. Which protein is encoded by this specific gene? | Uveal autoantigen with coiled-coil domains and ankyrin repeats | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05312","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that participates in programmed cell death. In a study of peripheral blood mo... | |
medium_hidden_intermediate_05313 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in nucleotide salvage. Evidence for this gene reports a log2 fold change of 3.828 and an adjusted p-value of 0.004368. Which protein is encoded by this gene? | Uridine phosphorylase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05313","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in nucleotide salvage. Evidence f... | |
medium_hidden_intermediate_05314 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to congestive heart failure via association. One of these genes was reported in a study using a non-small cell lung adenocarcinoma cell line, showing a log2 fold change of approximately 1.02 and an adjusted p-value of 0.0... | Homeobox expressed in ES cells 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05314","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to congestive heart failu... | |
medium_hidden_intermediate_05315 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes that subsequently bind to MRPS34. One such gene exhibited a log2 fold change of 1.123 and an adjusted p-value of 9.131e-05. Which protein is encoded by this specific gene? | Large ribosomal subunit protein uL22m | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05315","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes ... | |
medium_hidden_intermediate_05319 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes that enable heparin binding. One such gene exhibits a log2 fold change of -2.038 and an adjusted p-value of 0.0145. Which protein does this specific gene product bind to? | TLL2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05319","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes that ... | |
medium_hidden_intermediate_05320 | Pegivirus C is reported to downregulate a specific gene, which is in turn associated with infectious mononucleosis. Experimental data for this gene in peripheral blood mononuclear cells (from study GSE131504) indicate a log2 fold change of -1.261 and an adjusted p-value of 0.002347. Which protein is encoded by this gen... | Septin-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05320","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which is in turn associated with infectious mononucleosis. Experime... | |
medium_hidden_intermediate_05321 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in zinc influx into cells by the SLC39 gene family. Evidence for one such gene reports a log2 fold change of 1.424 and an adjusted p-value of 0.04108. Which protein is encoded by that gene? | Zinc transporter SLC39A7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05321","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in zinc influx into cells by the ... | |
medium_hidden_intermediate_05322 | In a study of sclera cells (GSE164073), Severe acute respiratory syndrome-related coronavirus was found to upregulate a specific gene, which in turn interacts with RHOB. This gene exhibited a log2 fold change of approximately 3.78 and an adjusted p-value of 0.014. Which protein is encoded by this gene? | MAGUK p55 subfamily member 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05322","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of sclera cells (GSE164073), Severe acute respiratory syndrome-related coronavirus was found to upregulate a spec... | |
medium_hidden_intermediate_05324 | Human alphaherpesvirus 3 is known to downregulate certain genes that are located in the plasma membrane. One such gene exhibits a log2 fold change of -1.149 and an adjusted p-value of 0.004707 in a specific study. Which disease is associated with this gene as a biomarker? | congestive heart failure | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05324","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 is known to downregulate certain genes that are located in the plasma membrane. One such gene exhib... | |
medium_hidden_intermediate_05325 | Two genes are linked to Vaccinia virus via downregulation and to pediatric osteosarcoma via biomarker association. One of these genes exhibits a log2 fold change of -1.865 and an adjusted p-value of 0.01585 in cervical adenocarcinoma cell lines (study GSE11238). Which protein is encoded by the gene matching these stati... | Eukaryotic translation initiation factor 2-alpha kinase 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05325","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Vaccinia virus via downregulation and to pediatric osteosarcoma via biomarker association. One of th... |
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