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medium_hidden_intermediate_05326 | In a study involving Human gammaherpesvirus 8, a specific gene is downregulated and is known to enable RNA binding. Experimental data for this gene reports a log2 fold change of approximately -1.259 and an adjusted p-value of 0.02384. Which protein is encoded by this gene? | Mesencephalic astrocyte-derived neurotrophic factor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05326","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study involving Human gammaherpesvirus 8, a specific gene is downregulated and is known to enable RNA binding. Experime... | |
medium_hidden_intermediate_05327 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are located in microtubules. One of these genes exhibits a log2 fold change of -1.080 and an adjusted p-value of 6.508e-07 in a specific study. Which cell type is enriched for this specific gene? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05327","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are located in microtubules. One of... | |
medium_hidden_intermediate_05328 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes involved in the positive regulation of transcription elongation by RNA polymerase II. One such gene exhibited a log2 fold change of 1.037 and an adjusted p-value of 5.19e-11. Which protein is enc... | Mediator of RNA polymerase II transcription subunit 16 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05328","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes... | |
medium_hidden_intermediate_05330 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and participates in collagen formation. This gene exhibits a log2 fold change of approximately 1.206 and an adjusted p-value of 0.001265. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05330","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and participat... | |
medium_hidden_intermediate_05332 | Zika virus downregulates a gene that is located in the autophagosome. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -2.272 and an adjusted p-value of 0.004134. Which protein is encoded by this specific gene? | Syntaxin-17 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05332","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in the autophagosome. In a study of glioma stem cells (GSE114907), one such ... | |
medium_hidden_intermediate_05333 | Zika virus downregulates a gene that participates in factors involved in megakaryocyte development and platelet production. Evidence for one such gene reports a log2 fold change of -1.855 and an adjusted p-value of 0.01832. Which disease is associated with that gene? | glioma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05333","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in factors involved in megakaryocyte development and platelet production. ... | |
medium_hidden_intermediate_05334 | Measles morbillivirus upregulates a gene that is located in the endosome membrane. Experimental data for this gene reports a log2 fold change of 1.022 and an adjusted p-value of 0.001177. Which protein is encoded by this gene? | Sorting nexin-16 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05334","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is located in the endosome membrane. Experimental data for this gene reports a... | |
medium_hidden_intermediate_05336 | Human alphaherpesvirus 1 is known to downregulate certain genes that enable cysteine-type endopeptidase activity. In a study of monocytic leukemia cell lines (GSE114966), one such gene exhibited a log2 fold change of -1.268 and an adjusted p-value of 0.003694. Which protein is encoded by this specific gene? | Cathepsin O | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05336","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 is known to downregulate certain genes that enable cysteine-type endopeptidase activity. In a study... | |
medium_hidden_intermediate_05337 | Hepacivirus C upregulates a gene that enables small GTPase binding. Evidence for one such gene reports a log2 fold change of 1.059 and an adjusted p-value of 0.001247. Which cellular component is that gene located in? | endosome membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05337","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that enables small GTPase binding. Evidence for one such gene reports a log2 fold change of... | |
medium_hidden_intermediate_05341 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is located in the microtubule. Evidence for this specific gene reports a log2 fold change of -1.080 and an adjusted p-value of 6.508e-07. Which protein is encoded by this gene? | Tubulin polyglutamylase complex subunit 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05341","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is located in the microtubule. Evidence for ... | |
medium_hidden_intermediate_05342 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes that enable sequence-specific DNA binding. One such gene exhibited a log2 fold change of approximately 1.794 and an adjusted p-value of 8.614e-05. Which protein is encoded by this specific gene? | Nuclear receptor subfamily 2 group F member 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05342","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes... | |
medium_hidden_intermediate_05343 | Pegivirus C downregulates a specific gene, which in turn interacts with CUL3. Experimental data for this gene in peripheral blood mononuclear cells (from study GSE131504) shows a log2 fold change of approximately -1.596 and an adjusted p-value of 0.0002127. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05343","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a specific gene, which in turn interacts with CUL3. Experimental data for this gene in peripheral ... | |
medium_hidden_intermediate_05344 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the processing of capped intron-containing pre-mRNA. One of these genes is associated with a log2 fold change of 1.542 and an adjusted p-value of 0.04172. Which protein is encoded by this specific gene? | Nucleoporin Nup37 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05344","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the processing of capp... | |
medium_hidden_intermediate_05345 | Human betaherpesvirus 5 upregulates a gene that participates in glycerophospholipid biosynthesis. Experimental data for this gene in a retinal pigment epithelium cell line (study GSE120891) reports a log2 fold change of approximately 1.019 and an adjusted p-value of 0.007212. Which protein does this gene product intera... | VDAC1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05345","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that participates in glycerophospholipid biosynthesis. Experimental data for this... | |
medium_hidden_intermediate_05347 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the negative regulation of the apoptotic process. Evidence for one such gene reports a log2 fold change of 2.900 and an adjusted p-value of 5.224e-16. Which protein does this specific gene product bind to? | TNFRSF18 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05347","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the negative regulation of the ... | |
medium_hidden_intermediate_05348 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, which is enriched in classical monocytes. This gene exhibited a log2 fold change of 2.927 and an adjusted p-value of 5.188e-07. Which protein is encoded by this gene? | Neurolysin, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05348","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_05349 | A gene is upregulated by Human immunodeficiency virus 1 and is involved in cell-cell signaling. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of 2.717 and an adjusted p-value of 0.00225. Which disease is associated with this gene through genomic alterations? | leprosy | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05349","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human immunodeficiency virus 1 and is involved in cell-cell signaling. Evidence for this gene in ma... | |
medium_hidden_intermediate_05350 | Human betaherpesvirus 5 upregulates a gene that participates in Class I MHC mediated antigen processing & presentation. In a study of monocytes (GSE11408), one such gene showed a log2 fold change of approximately 1.47 and an adjusted p-value of 0.0128. Which protein does this specific gene interact with? | PRNP | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05350","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that participates in Class I MHC mediated antigen processing & presentation. In a... | |
medium_hidden_intermediate_05351 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific gene that enables guanyl-nucleotide exchange factor activity. This gene exhibited a log2 fold change of approximately -2.41 and an adjusted p-value of 0.034. Which protein is encoded by this gene? | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05351","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific g... | |
medium_hidden_intermediate_05353 | Two genes are structurally linked in a pathway starting from Human immunodeficiency virus 1 (via downregulation) and ending at autosomal dominant optic atrophy, classic form (via association). One of these genes is reported in a study (GSE125686) involving natural killer cells, with a log2 fold change of approximately ... | Embigin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05353","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked in a pathway starting from Human immunodeficiency virus 1 (via downregulation) and ending ... | |
medium_hidden_intermediate_05354 | Zika virus downregulates a specific gene that participates in the process where SUMO E3 ligases SUMOylate target proteins. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -1.53 and an adjusted p-value of 0.0053. Which disease is associated with this gene? | neurodevelopmental disorder with achalasia, polyneuropathy, and alacrima | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05354","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in the process where SUMO E3 ligases SUMOylate target proteins. I... | |
medium_hidden_intermediate_05355 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with FEZ1. Evidence for one such gene reports a log2 fold change of 1.374 and an adjusted p-value of 0.001816. Which protein is encoded by that gene? | Huntingtin-associated protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05355","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with FEZ1. Evidence for one such gen... | |
medium_hidden_intermediate_05356 | Pegivirus C is reported to downregulate a specific gene, which in turn participates in the activity of Ub-specific processing proteases. Experimental data for this gene, derived from peripheral blood mononuclear cells in study GSE131504, indicates a log2 fold change of -1.821 and an adjusted p-value of 0.0009977. Which... | gastric carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05356","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn participates in the activity of Ub-specific processin... | |
medium_hidden_intermediate_05358 | Human betaherpesvirus 5 is reported to downregulate a gene that is enriched in basophils. Experimental data for this gene in foreskin fibroblast cell lines shows a log2 fold change of -1.115 and an adjusted p-value of 2.862e-05. Which protein is encoded by this gene? | Low-density lipoprotein receptor-related protein 12 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05358","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that is enriched in basophils. Experimental data for this gene in... | |
medium_hidden_intermediate_05360 | A gene serves as a marker for liver bud hepatic cells and is enriched in plasmacytoid dendritic cells (pDCs). Evidence for one such gene reports a mean expression of 7.40 TPM, a z-score of 3.85, and a fold enrichment of 35.74. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05360","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for liver bud hepatic cells and is enriched in plasmacytoid dendritic cells (pDCs). Evidence for o... | |
medium_hidden_intermediate_05362 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with leukemia. One of these genes exhibits a log2 fold change of approximately 2.85 and an adjusted p-value of 0.0169 in a specific study. Which cell type is enriched for this specific gene? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05362","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with leukemia. One of ... | |
medium_hidden_intermediate_05364 | Two genes interact with HSF1 and participate in post-translational protein modification. One of these genes is described by the following evidence: 'Subsequently, the gene product translocated into the nucleus and bound cooperatively with nuclear HSF1 (heat shock transcription factor 1) onto the ATG7 promoter, upregula... | malignant pancreatic neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05364","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes interact with HSF1 and participate in post-translational protein modification. One of these genes is described by ... | |
medium_hidden_intermediate_05366 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is downregulated by the virus and participates in the cellular response to chemical stress. This gene exhibits a log2 fold change of -1.702 and an adjusted p-value of 0.008429. Which protein does this gene interact w... | HSPA5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05366","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is downregulated by ... | |
medium_hidden_intermediate_05367 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and serves as a biomarker for type 1 diabetes mellitus 1. Evidence for this gene reports a log2 fold change of 1.733 and an adjusted p-value of 0.006842. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05367","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and serves as a biomarker for type 1 diabetes... | |
medium_hidden_intermediate_05368 | Two genes are linked to PRKN via protein-protein interactions and are both enriched in basophils. One of these genes exhibits a mean expression of 74.77 TPM, a z-score of 2.41, and a fold enrichment of 5.20 in immune cell RNA-seq data. Which biological process is associated with this specific gene? | cholesterol homeostasis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05368","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to PRKN via protein-protein interactions and are both enriched in basophils. One of these genes exhibit... | |
medium_hidden_intermediate_05369 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the positive regulation of angiogenesis. One of these genes exhibits a log2 fold change of -3.031 and an adjusted p-value of 0.004225 in a specific study. Which cell type is enriched for this specific gene? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05369","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the positive regula... | |
medium_hidden_intermediate_05370 | Human immunodeficiency virus 1 downregulates a gene that is associated with lung carcinoma. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of -2.482 and an adjusted p-value of 0.0007483. Which protein is encoded by this gene? | Semaphorin-3C | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05370","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is associated with lung carcinoma. In a study of macrophages (GSE10... | |
medium_hidden_intermediate_05371 | Two genes are structurally linked to Vaccinia virus via a 'downregulates' relationship and to Cell Cycle Checkpoints via a 'participates in' relationship. One of these genes has an associated expression profile showing a log2 fold change of -2.206 and an adjusted p-value of 0.003359. Which disease is connected to this ... | salivary gland cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05371","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Vaccinia virus via a 'downregulates' relationship and to Cell Cycle Checkpoints via a '... | |
medium_hidden_intermediate_05372 | In a study of glioma stem cells (GSE114907), Zika virus infection leads to the downregulation of a specific gene, which in turn interacts with COMMD2. The downregulated gene exhibits a log2 fold change of approximately -1.105 and an adjusted p-value of 0.02543. Which protein is encoded by this downregulated gene? | DENN domain-containing protein 10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05372","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), Zika virus infection leads to the downregulation of a specific gene, which in t... | |
medium_hidden_intermediate_05373 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in turn interacts with RPL7A. This gene exhibited a log2 fold change of -1.327 and an adjusted p-value of 0.004363. Which protein is encoded by this gene? | Nucleolar protein 16 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05373","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in tu... | |
medium_hidden_intermediate_05377 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and both bind to FANCF. One of these genes exhibits a log2 fold change of -1.334 and an adjusted p-value of 0.00043 in a specific study. Which protein is encoded by this gene? | Structure-specific endonuclease subunit EME1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05377","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and both bind to FANCF. One of these ge... | |
medium_hidden_intermediate_05378 | A gene is upregulated by Human immunodeficiency virus 1 and is enriched in Regulatory T (Treg) cells. Evidence for this gene reports a log2 fold change of 1.115 and an adjusted p-value of 8.492e-05. Which protein is encoded by this gene? | Coiled-coil domain-containing protein 167 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05378","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human immunodeficiency virus 1 and is enriched in Regulatory T (Treg) cells. Evidence for this gene... | |
medium_hidden_intermediate_05379 | In a study of Hepacivirus C infection in peripheral blood mononuclear cells (GSE119117), two genes are downregulated by the virus and participate in aerobic respiration and respiratory electron transport. One of these genes exhibits a log2 fold change of -1.073 and an adjusted p-value of 0.0004737. What molecular funct... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05379","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Hepacivirus C infection in peripheral blood mononuclear cells (GSE119117), two genes are downregulated by the ... | |
medium_hidden_intermediate_05380 | In a study of Hepacivirus C infection in hepatocytes (GSE132606), two genes are reported to be downregulated by the virus and to interact with NPM1. One of these genes exhibits a log2 fold change of approximately -1.20 and an adjusted p-value of 0.0426. Which protein is encoded by this specific gene? | DnaJ homolog subfamily B member 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05380","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Hepacivirus C infection in hepatocytes (GSE132606), two genes are reported to be downregulated by the virus an... | |
medium_hidden_intermediate_05381 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and binds to PEX14. This specific gene exhibits a log2 fold change of approximately 1.56 and an adjusted p-value of approximately 4.16e-06. Which protein is encoded by this gene? | Dehydrogenase/reductase SDR family member 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05381","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and binds to PEX14. Thi... | |
medium_hidden_intermediate_05383 | A gene is downregulated by Primate bocaparvovirus 1 and interacts with SET. Experimental data for this gene in tracheobronchial epithelial cells (study GSE102392) reports a log2 fold change of approximately -1.206 and an adjusted p-value of 0.03159. Which disease is associated with this gene through genomic alterations... | gastric carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05383","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and interacts with SET. Experimental data for this gene in tracheobronch... | |
medium_hidden_intermediate_05385 | Measles morbillivirus upregulates a gene that participates in the degradation of the extracellular matrix. Evidence for one such gene reports a log2 fold change of 1.097 and an adjusted p-value of 0.01715. Which protein is encoded by that gene? | Stromelysin-3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05385","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that participates in the degradation of the extracellular matrix. Evidence for one ... | |
medium_hidden_intermediate_05386 | Measles morbillivirus upregulates a gene that participates in CHD chromatin remodeler activity. Evidence for one such gene reports a log2 fold change of 1.620 and an adjusted p-value of 0.001189. Which protein is encoded by that gene? | Zinc finger protein 532 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05386","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that participates in CHD chromatin remodeler activity. Evidence for one such gene r... | |
medium_hidden_intermediate_05387 | Two genes are linked to Human alphaherpesvirus 1 via upregulation and to glioma as biomarkers. One of these genes exhibits a log2 fold change of approximately 1.35 and an adjusted p-value of approximately 0.0165 in a monocytic leukemia cell line study (GSE114966). Which protein is encoded by this specific gene? | Inhibitor of growth protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05387","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Human alphaherpesvirus 1 via upregulation and to glioma as biomarkers. One of these genes exhibits a... | |
medium_hidden_intermediate_05389 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Meiosis. Experimental data for this gene shows a log2 fold change of 4.295 and an adjusted p-value of 0.0125. Which protein is encoded by this gene? | Histone H3.1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05389","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Meiosis. Experimental dat... | |
medium_hidden_intermediate_05390 | Two genes are downregulated by Vaccinia virus and enriched in Gamma delta (γδ) T cells. One of these genes exhibits a log2 fold change of approximately -2.455 and an adjusted p-value of 0.03357 in cervical adenocarcinoma cell lines. Which cellular component is the location of this specific gene? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05390","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Vaccinia virus and enriched in Gamma delta (γδ) T cells. One of these genes exhibits a log2 f... | |
medium_hidden_intermediate_05391 | Human alphaherpesvirus 1 upregulates a gene that participates in metabolism. In a study of monocytic leukemia cell lines (GSE114966), one such gene showed a log2 fold change of 1.143 and an adjusted p-value of 0.00148. Which protein is encoded by this gene? | Peroxisomal membrane protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05391","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that participates in metabolism. In a study of monocytic leukemia cell lines (GS... | |
medium_hidden_intermediate_05392 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to Gamma delta (γδ) T cells via an 'enriched in' relationship. One of these genes is associated with experimental data showing a log2 fold change of -1.070 and an adjusted p-value of 0.00715... | Cell growth-regulating nucleolar protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05392","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_05393 | Bivalirudin and Edoxaban are both connected via drug-drug interactions to a specific intermediate agent. Clinical evidence regarding this intermediate agent notes that while streptokinase was the fibrinolytic agent used in most studies, this specific agent was utilized in the TIMI-5 trial. What disease is this intermed... | acute myocardial infarction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05393","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Bivalirudin and Edoxaban are both connected via drug-drug interactions to a specific intermediate agent. Clinical evidence r... | |
medium_hidden_intermediate_05395 | Zika virus downregulates a gene that is involved in the negative regulation of the cell cycle. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -2.244 and an adjusted p-value of 0.005824. Which molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05395","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the negative regulation of the cell cycle. In a study of glioma stem cel... | |
medium_hidden_intermediate_05399 | Zika virus downregulates a specific gene, the product of which binds to YTHDC1. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -2.13 and an adjusted p-value of 0.0165. Which protein is encoded by this gene? | Exosome complex component RRP41 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05399","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, the product of which binds to YTHDC1. In a study of glioma stem cells (GSE114907),... | |
medium_hidden_intermediate_05400 | In a study of non-small cell lung adenocarcinoma cell lines, Influenza A virus infection was found to downregulate a specific gene, which is involved in the positive regulation of cell population proliferation. The expression data for this gene shows a log2 fold change of -1.171 and an adjusted p-value of 1.052e-05. Wh... | F-box only protein 50 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05400","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines, Influenza A virus infection was found to downregulate a specifi... | |
medium_hidden_intermediate_05401 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes whose products are located in the cytoplasm. One such gene exhibits a log2 fold change of -2.755 and an adjusted p-value of 7.005e-05. Which protein is encoded by this specific gene? | Prostaglandin G/H synthase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05401","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes whose... | |
medium_hidden_intermediate_05402 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and associated with drug dependence was found to have a log2 fold change of approximately 3.22 and an adjusted p-value of approximately 6.45e-07. Which protein is encoded by this specific gene? | Glycoprotein endo-alpha-1,2-mannosidase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05402","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and associated with drug d... | |
medium_hidden_intermediate_05405 | A gene is downregulated by Cardiovirus A and participates in the Generic Transcription Pathway. Experimental data for this gene reports a log2 fold change of -1.286 and an adjusted p-value of 0.01258. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05405","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Cardiovirus A and participates in the Generic Transcription Pathway. Experimental data for this g... | |
medium_hidden_intermediate_05409 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Interleukin-37 signaling. One of these genes shows a log2 fold change of 1.078 and an adjusted p-value of 0.0246 in a specific cell type. Which cell type is enriched for this specific gene? | gamma-delta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05409","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Interleukin-37 signali... | |
medium_hidden_intermediate_05410 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and to the biological process 'Regulation of T cell activation by CD28 family' via a 'participates in' relationship. One of these genes is associated with experimental data showing a log2 fold ch... | Derlin-3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05410","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship... | |
medium_hidden_intermediate_05411 | Two genes are structurally linked to EGFR via an interaction and to basophils via enrichment. One of these genes encodes a protein described in the following evidence: 'Here, we report a novel interaction of EGFR with an HECT-type ubiquitin ligase, which can ubiquitinate, but stabilize EGFR by protecting it from c-Cbl-... | E3 ubiquitin-protein ligase SMURF2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05411","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to EGFR via an interaction and to basophils via enrichment. One of these genes encodes a p... | |
medium_hidden_intermediate_05412 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in turn binds to EXOSC6. This gene exhibited a log2 fold change of -1.275 and an adjusted p-value of 0.00856. Which protein is encoded by this downregulated gene? | Exosome complex component RRP41 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05412","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in tu... | |
medium_hidden_intermediate_05413 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of a specific gene, which in turn interacts with NHERF1. This gene exhibits a log2 fold change of approximately 1.93 and an adjusted p-value of approximately 0.012. Which protein is encoded by this upregulated gene? | PH domain leucine-rich repeat-containing protein phosphatase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05413","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of a specific gene, whic... | |
medium_hidden_intermediate_05415 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables protein-containing complex binding. Transcriptomic data for this gene reports a log2 fold change of approximately 1.46 and an adjusted p-value of 0.0024. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05415","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables protein-containing complex bindin... | |
medium_hidden_intermediate_05416 | Human immunodeficiency virus 1 upregulates a gene that is involved in the response to virus. Evidence for one such gene reports a log2 fold change of 1.594 and an adjusted p-value of 0.03509. Which protein is encoded by that gene? | Interferon-induced protein 44 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05416","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is involved in the response to virus. Evidence for one such gene repo... | |
medium_hidden_intermediate_05418 | Human immunodeficiency virus 1 upregulates a gene that is involved in the positive regulation of autophagy. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of approximately 1.063 and an adjusted p-value of 0.0002927. Which protein is encoded by this specific gene? | Endonuclease G, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05418","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is involved in the positive regulation of autophagy. In a study of ma... | |
medium_hidden_intermediate_05419 | In a study of lung cells (GSE155241), Severe acute respiratory syndrome-related coronavirus was found to upregulate a specific gene, which in turn interacts with the SET protein. This gene exhibited a log2 fold change of 1.747 and an adjusted p-value of 0.006125. Which protein is encoded by this gene? | Serine protease FAM111B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05419","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells (GSE155241), Severe acute respiratory syndrome-related coronavirus was found to upregulate a specif... | |
medium_hidden_intermediate_05422 | In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is identified as being downregulated by Human gammaherpesvirus 8 and involved in the positive regulation of cell population proliferation. This specific gene exhibits a log2 fold change of approximately -1.35 and an adjusted p-value of approximately 0.03... | COP9 signalosome complex subunit 9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05422","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is identified as being downregulated by Human gammaherpesv... | |
medium_hidden_intermediate_05423 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which in turn interacts with SNRPA. This gene exhibits a log2 fold change of -1.387 and an adjusted p-value of 0.01818. Which protein is encoded by this gene? | Heterogeneous nuclear ribonucleoprotein H3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05423","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_05425 | Salivary gland neoplasms are anatomically associated with a specific cranial nerve. Evidence indicates that this cranial nerve branches into the ramus communicans (supplying the skin), the petrosal branch (supplying the walls of the pharynx and mouth with viscero-sensory fibers), and a larval post-trematic branch (whic... | medulla oblongata | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05425","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Salivary gland neoplasms are anatomically associated with a specific cranial nerve. Evidence indicates that this cranial ner... | |
medium_hidden_intermediate_05427 | Zika virus downregulates a gene that is involved in lipid metabolic processes. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -1.104 and an adjusted p-value of 0.03929. Which protein is encoded by this specific gene? | Choline/ethanolaminephosphotransferase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05427","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in lipid metabolic processes. In a study of glioma stem cells (GSE114907), ... | |
medium_hidden_intermediate_05430 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with HIST1H4A. Experimental data for this gene reports a log2 fold change of 1.124 and an adjusted p-value of 0.00602. Which disease is associated with this gene? | congenital heart disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05430","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with HIST1H4A. Experimental dat... | |
medium_hidden_intermediate_05431 | Hepacivirus C is reported to downregulate a specific gene that is located in the endoplasmic reticulum. Experimental evidence for this gene shows a log2 fold change of approximately -1.46 and an adjusted p-value of approximately 0.00038. Which disease is associated with this gene as a biomarker? | myelodysplastic syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05431","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a specific gene that is located in the endoplasmic reticulum. Experimental evidenc... | |
medium_hidden_intermediate_05434 | In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and participates in Telomere Maintenance. This specific gene exhibits a log2 fold change of approximately 1.23 and an adjusted p-value of approximately 0.0002. Which protein is encoded by this gene? | H/ACA ribonucleoprotein complex subunit 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05434","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and participates in Telomere ... | |
medium_hidden_intermediate_05435 | Enterovirus A is reported to downregulate multiple genes that participate in the RHO GTPase cycle. One such gene exhibits a log2 fold change of -1.338 and an adjusted p-value of 1.054e-05 in rhabdomyosarcoma cells. Which protein is encoded by this specific gene? | Stomatin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05435","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is reported to downregulate multiple genes that participate in the RHO GTPase cycle. One such gene exhibits a ... | |
medium_hidden_intermediate_05437 | Two genes are downregulated by Measles morbillivirus and participate in diseases associated with O-glycosylation of proteins. One of these genes exhibits a log2 fold change of approximately -1.001 and an adjusted p-value of 0.03461 in pleural mesothelioma cells. Which cell type is enriched for this specific gene? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05437","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Measles morbillivirus and participate in diseases associated with O-glycosylation of proteins... | |
medium_hidden_intermediate_05438 | In a study of Measles morbillivirus infection, multiple genes are upregulated by the virus and subsequently interact with the protein UBC. One such gene exhibits a log2 fold change of 2.725 and an adjusted p-value of 0.03476. Which protein is encoded by this specific gene? | OTU domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05438","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, multiple genes are upregulated by the virus and subsequently interact with th... | |
medium_hidden_intermediate_05439 | Vaccinia virus infection leads to the upregulation of specific genes that are localized to the mitochondrial outer membrane. One such gene exhibits a log2 fold change of approximately 1.207 and an adjusted p-value of 0.01063 in cervical adenocarcinoma cells. In which cell type is this specific gene enriched? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05439","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus infection leads to the upregulation of specific genes that are localized to the mitochondrial outer membrane.... | |
medium_hidden_intermediate_05440 | Two genes are upregulated by Vaccinia virus and both bind to TPM2. One of these genes shows a log2 fold change of 1.823 and an adjusted p-value of 0.0006521 in a specific study. Which disease is associated with this specific gene? | prostate adenocarcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05440","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and both bind to TPM2. One of these genes shows a log2 fold change of 1.823 and ... | |
medium_hidden_intermediate_05441 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE148697), a specific gene is upregulated and involved in cell-cell signaling. This gene exhibits a log2 fold change of approximately 1.56 and an adjusted p-value of approximately 0.00083. Which protein is encoded by this gen... | Tumor necrosis factor ligand superfamily member 9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05441","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE148697), a specific gene is... | |
medium_hidden_intermediate_05443 | In a study of peripheral blood mononuclear cells (GSE131504), a gene is identified as being downregulated by Pegivirus C and is associated with the biological process of transmembrane transporter binding. This specific gene exhibits a log2 fold change of -1.769 and an adjusted p-value of 0.002799. Which protein is enco... | TRPM8 channel-associated factor 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05443","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of peripheral blood mononuclear cells (GSE131504), a gene is identified as being downregulated by Pegivirus C and... | |
medium_hidden_intermediate_05446 | In a study of Human alphaherpesvirus 1 infection in a monocytic leukemia cell line, a specific gene is upregulated by the virus and binds to UBE2M. This gene exhibits a log2 fold change of approximately 1.149 and an adjusted p-value of 0.01016. Which biological process is this gene involved in? | epigenetic regulation of gene expression | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05446","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Human alphaherpesvirus 1 infection in a monocytic leukemia cell line, a specific gene is upregulated by the vi... | |
medium_hidden_intermediate_05447 | Hepacivirus C upregulates a gene that participates in chromatin organization. Evidence for one such gene reports a log2 fold change of 1.319 and an adjusted p-value of 0.0007364. Which protein is encoded by that gene? | Lysine-specific demethylase 5D | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05447","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in chromatin organization. Evidence for one such gene reports a log2 fold... | |
medium_hidden_intermediate_05448 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that subsequently interacts with AIFM1. One such gene exhibits a log2 fold change of 1.052 and an adjusted p-value of 0.007262. Which protein is encoded by this specific gene? | Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05448","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that subsequently interacts with AI... | |
medium_hidden_intermediate_05449 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus was found to upregulate a gene that participates in Cytokine Signaling in the Immune system. One such gene exhibited a log2 fold change of 1.278 and an adjusted p-value of 0.01732. Which protein is encoded by this specific gene? | Gamma-interferon-inducible lysosomal thiol reductase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05449","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus was found to upregulate a gene that participates... | |
medium_hidden_intermediate_05450 | Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to transcription cis-regulatory region binding via an 'enables' relationship. One of these genes has a reported log2 fold change of -2.751 and an adjusted p-value of 0.02981 in a specific study. Which cell type is... | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05450","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to transcription ... | |
medium_hidden_intermediate_05452 | Human alphaherpesvirus 3 upregulates a gene that participates in RNA Polymerase II Transcription. Evidence for this gene in a melanoma cell line (study GSE136586) reports a log2 fold change of 3.046 and an adjusted p-value of 4.455e-12. Which protein is encoded by this gene? | Phorbol-12-myristate-13-acetate-induced protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05452","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 upregulates a gene that participates in RNA Polymerase II Transcription. Evidence for this gene in ... | |
medium_hidden_intermediate_05453 | A gene is downregulated by Measles morbillivirus and participates in Developmental Biology. Experimental evidence for this gene reports a log2 fold change of -1.216 and an adjusted p-value of 0.002578. Which disease is associated with this gene? | intellectual disability | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05453","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Measles morbillivirus and participates in Developmental Biology. Experimental evidence for this g... | |
medium_hidden_intermediate_05455 | In a study of glioma stem cells (GSE114907), Zika virus infection leads to the downregulation of a specific gene, which in turn encodes a protein that binds to YES1. The expression data for this gene shows a log2 fold change of -2.836 and an adjusted p-value of 0.007173. Which protein is encoded by this gene? | ARF GTPase-activating protein GIT2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05455","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), Zika virus infection leads to the downregulation of a specific gene, which in t... | |
medium_hidden_intermediate_05456 | In a study of Rift Valley fever phlebovirus infection in SAEC cells (GSE102481), multiple genes are upregulated by the virus and enriched in neutrophils. One such gene exhibits a log2 fold change of approximately 1.643 and an adjusted p-value of 0.01108. Which biological process is this specific gene involved in? | positive regulation of inflammatory response | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05456","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Rift Valley fever phlebovirus infection in SAEC cells (GSE102481), multiple genes are upregulated by the virus... | |
medium_hidden_intermediate_05457 | Measles morbillivirus downregulates a gene that interacts with UBE2I. Evidence for one such gene reports a log2 fold change of -1.267 and an adjusted p-value of 0.00264. Which cellular component is that gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05457","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus downregulates a gene that interacts with UBE2I. Evidence for one such gene reports a log2 fold change ... | |
medium_hidden_intermediate_05458 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with CEP135. One of these genes was reported in a study on sclera cells with a log2 fold change of approximately 1.14 and an adjusted p-value of 0.0039. Which protein is encoded by this specific gene? | Coiled-coil domain-containing protein 77 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05458","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with CEP135. One of these ge... | |
medium_hidden_intermediate_05460 | In a study of Influenza A virus infection, a specific gene is upregulated and its product is located in the lysosomal membrane. Evidence for this gene reports a log2 fold change of approximately 1.22 and an adjusted p-value of 0.0005941. Which protein is encoded by this gene? | Lysosomal-associated transmembrane protein 4B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05460","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is upregulated and its product is located in the lysosomal membra... | |
medium_hidden_intermediate_05462 | Zika virus downregulates a specific gene that interacts with PCM1. Experimental data for this gene shows a log2 fold change of -2.878 and an adjusted p-value of 0.0134. In which cell type is this gene enriched? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05462","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that interacts with PCM1. Experimental data for this gene shows a log2 fold change ... | |
medium_hidden_intermediate_05463 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables magnesium ion binding. Experimental data for this gene in a colonic adenocarcinoma cell line (study GSE148729) reports a log2 fold change of approximately -1.411 and an adjusted p-value of 0.04683. Which gene interacts with thi... | CAMK2A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05463","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables magnesium ion binding. Experime... | |
medium_hidden_intermediate_05465 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a specific gene that subsequently interacts with CCNF. This gene exhibits a log2 fold change of 1.366 and an adjusted p-value of 0.0007526. Which cellular component is this gene located in? | cytosol | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05465","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus upregulates a specific gene that subsequently in... | |
medium_hidden_intermediate_05466 | In a study of glioma stem cells (GSE114907), Zika virus infection leads to the downregulation of a specific gene, which in turn encodes a protein that binds to MED1. One such gene exhibits a log2 fold change of -2.225 and an adjusted p-value of 0.03674. Which protein is encoded by this gene? | Steroid hormone receptor ERR1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05466","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), Zika virus infection leads to the downregulation of a specific gene, which in t... | |
medium_hidden_intermediate_05467 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enriched in Naive CD8+ T cells. Evidence for this gene reports a log2 fold change of 1.253 and an adjusted p-value of 0.04321. Which protein is encoded by this gene? | Methionine aminopeptidase 1D, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05467","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enriched in Naive CD8+ T cells. Evidence ... | |
medium_hidden_intermediate_05468 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables sialyltransferase activity. Experimental data for this gene in lung tissue shows a log2 fold change of approximately 2.30 and an adjusted p-value of 0.0293. Which biological process is this gene involved in? | glycoprotein biosynthetic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05468","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables sialyltransferase activity. Exper... | |
medium_hidden_intermediate_05469 | Two genes are known to be downregulated by Human immunodeficiency virus 1 and to enable microtubule binding. One of these genes exhibits a log2 fold change of -1.825 and an adjusted p-value of 0.01487 in macrophages (study GSE108897). Which disease is associated with this specific gene as a biomarker? | colon carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05469","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are known to be downregulated by Human immunodeficiency virus 1 and to enable microtubule binding. One of these ge... | |
medium_hidden_intermediate_05470 | In a study of macrophages (GSE108897), a gene upregulated by Human immunodeficiency virus 1 and involved in Vesicle-mediated transport was found to have a log2 fold change of approximately 1.15 and an adjusted p-value of 0.007. Which protein does this specific gene interact with? | MAP1LC3A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05470","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene upregulated by Human immunodeficiency virus 1 and involved in Vesicle-mediated... | |
medium_hidden_intermediate_05472 | Zika virus downregulates a specific gene, which is associated with adenoviridae infectious disease. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -1.037 and an adjusted p-value of 0.01023. Which protein is encoded by this gene? | Proprotein convertase subtilisin/kexin type 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05472","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which is associated with adenoviridae infectious disease. In a study of glioma ste... | |
medium_hidden_intermediate_05475 | Severe acute respiratory syndrome-related coronavirus is linked to Cardiac conduction via a gene that is downregulated by the virus and participates in the conduction process. One such gene exhibits a log2 fold change of -1.786 and an adjusted p-value of 0.01708. Which protein is encoded by this specific gene? | Potassium voltage-gated channel subfamily E member 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_05475","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus is linked to Cardiac conduction via a gene that is downregulated by th... |
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